RNA encoding an antibody

ABSTRACT

The present invention relates to a RNA encoding an antibody or a fragment or variant thereof and a composition, in particular a passive vaccine, comprising such an RNA. The present invention further relates to the use of such an RNA or of such a composition for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, autoimmune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention also relates to a combination of at least two modified RNA&#39;s, in particular wherein one RNA encodes a heavy chain variable region of an antibody and another RNA encodes the corresponding light chain variable region of said antibody.

This application is a national phase application under 35 U.S.C. § 371of International Application No. PCT/EP2017/060226, filed Apr. 28, 2017,which claims benefit of International Application No. PCT/EP2016/059711,filed Apr. 29, 2016, the entire contents of each of which are herebyincorporated by reference.

The present invention relates to a RNA encoding an antibody or afragment or variant thereof and a composition, in particular a passivevaccine, comprising such an RNA. The present invention further relatesto the use of such an RNA or of such a composition for treatment oftumours and cancer diseases, cardiovascular diseases, infectiousdiseases, autoimmune diseases, virus diseases and monogenetic diseases,e.g. also in gene therapy. The present invention also relates to acombination of at least two modified RNA's, in particular wherein oneRNA encodes a heavy chain or a heavy chain variable region of anantibody and another RNA encodes the corresponding light chain or lightchain variable region of said antibody.

The occurrence of tumours and cancer diseases is, alongsidecardiovascular and infectious diseases, one of the most frequent causesof death in modern societies and is associated with usually considerablecosts during the therapy and subsequent rehabilitation measures. Thetreatment of tumours and cancer diseases depends greatly, for example,on the nature of the tumour which occurs and at present conventionallyis undertaken by using radio- or chemotherapy, in addition to invasiveinterventions. However, these therapies represent an exceptional burdenon the immune system, and in some cases can be employed to only alimited extent. Furthermore, these therapy forms usually require longpauses between the individual treatments for regeneration of the immunesystem. In recent years, alongside these “conventional methods”,molecular biology programmes in particular have emerged as promising forthe treatment or for assisting these therapies.

An example of these molecular biology methods comprises the use ofantibodies or immunoglobulins as essential effectors of the immunesystem. Antibodies or immunoglobulins can be generated either in vitroby using known molecular biology methods or by the immune system of theorganism itself to be treated. The immune system of higher vertebratesthus has two separate functions of the immune system: the innate immunesystem, which reacts non-specifically to pathogens (e.g. bymacrophage-mediated phagocytosis) and the adaptive immune system, whichreacts specifically to pathogens by means of specialized effector cells(e.g. B and T cells). The antibodies or immunoglobulins which aresecreted by plasma cells during an immune response are part of thisadaptive immune system. Together with the complement system, they formthe humoral branch of the immune response.

Alongside their essential importance for the immune system in highervertebrates, precisely because of their high affinity and specificityfor a particular antigen antibodies are an outstanding means both inbiochemical and molecular biology research and in diagnostics andmedical uses. Thus, antibodies are capable of binding specifically totheir target structures (e.g. antigens, which substantially compriseproteins, peptides, in some cases lipids, carbohydrates etc.) and ofthereby blocking (inhibiting) or, where appropriate, labelling these.They can moreover activate the immune system by means of their Fc part,so that the labelled cells are destroyed. Over 100 therapeuticantibodies are currently to be found in clinical studies. Antibodieswhich can be employed in cancer therapy play by far the most importantrole in this context. Most of the antibodies prepared for this atpresent are monoclonal antibodies which originate originally, forexample, from the mouse. In order to prevent an immune reaction againstsuch monoclonal antibodies, at present chiefly humanized or humanantibodies are employed for therapy (cf. David Male; “Immunologie aufeinen Blick [Immunology at a Glance]”, 1st German edition, 2005,Elsevier-Urban & Fischer Verlag; Charles A. Janeway, Paul Travers, MarkWalport and Mark Shlomchik, Immunobiology, 5th edition, 2001, GarlandPublishing; Dissertation by Christian Klein, Monoklonale Antikörper andrekombinante Antikörperfragmente gegen sekundäreArzneipflanzenmetabolite [Monoclonal Antibodies and Recombinant AntibodyFragments Against Secondary Medicinal Plant Metabolites], 2004; AndreasSchmiedl and Stefan Dübel, Rekombinante Antikörper & Phagen-Display[Recombinant Antibody & Phage Display], 2004, Molekulare Biotechnologie[Molecular Biotechnology] (Wiley-VCH)).

Antibodies are typically immunoglobulins or can be derived fromimmunoglobulins. Immunoglobulins can in turn be differentiated into fivemain classes of immunoglobulins on the basis of their heavy chain, theIgM (μ), IgD (δ), IgG (γ), IgA (α) and IgE (ε) antibodies, IgGantibodies making up the largest proportion. Immunoglobulins canmoreover be differentiated into the isotypes κ and λ on the basis oftheir light chains.

For example, IgG antibodies are typically built up two identical lightand two heavy protein chains which are bonded to one another viadisulfide bridges. As shown in FIG. 1 , the light chain comprises theN-terminal variable domain V_(L) (also referred to as “light chainvariable region”) and the C-terminal constant domain C_(L) (alsoreferred to as “light chain constant region”). The heavy chain of an IgGantibody can be divided into an N-terminal variable domain V_(H) (alsoreferred to as “heavy chain variable region”) and three constant domainsC_(H)1, C_(H)2 and C_(H)3 (all three constant domains together are alsoreferred to as “heavy chain constant region”). While the amino acidsequence is largely the same in the region of the constant domains, widedifferences in sequence are typically found within the variable domains.

The antibody repertoire of a human comprises about at least 10¹¹different antibody specificities. In higher vertebrates, the formationof antibodies takes place naturally in the immune system by somaticrecombination. In this context, an organism is indeed theoreticallycapable of generating an antibody of appropriate specificity against anyantigen. However, if each of these antibodies were to be coded by anendogenous gene, they would burst the human genome. Instead, in humansantibody genes are composed of a large number of individual genesegments. The part of the antibody gene which codes for the variableregion of a light chain is formed from a V gene segment and a J genesegment. In this context, numerous different V and J segments areavailable, which can be combined with one another virtually as desired.In this context, the variable region of a heavy chain is composed ofthree different gene segments. In addition to the V and J segments,additional D segments are also found here. The V_(H), D_(H) and J_(H)segments can likewise be combined with one another virtually as desiredto form the variable region of the heavy chain (cf. FIG. 2 ). Themechanism by which the various gene segments are combined to formcomplete antibody genes is called immunoglobulin rearrangement orsomatic recombination. It takes place exclusively in B lymphocytes atcertain times of cell development.

In addition to pure gene rearrangement, further mechanisms forincreasing the antibody diversity also exist. Two mechanisms which areaccompanied by somatic recombination are first to be mentioned in thiscontext: The junctional diversity in this context describes controlledimprecise joining together of the rearranged gene segments, as a resultof which random removal and insertion of nucleotides occurs at thecleavage sites. A further combinatorial diversity results from thepossibility of combining a particular rearranged light chain with aparticular rearranged heavy chain. Finally, the diversity of antibodiesis also additionally increased after successful rearrangement and lateractivation of B cells, in that an affinity maturation of antibodiesoccurs due to an increased rate of mutation in the region of thevariable regions of activated B cells (somatic hypermutation).

In addition to the formation of antibodies which takes place naturallyby the immune system of the particular organism, antibodies can also begenerated by molecular biology methods. However, in order to utilize thesystem elaborated for specification of antibody formation andspecification thereof for particular antigens or nucleic acids, theformation of antibodies is at present typically induced in selectedorganisms by injection of a particular antigen, and the antibody is thenisolated from the organism for further use. In this context, the Blymphocytes of the organism are conventionally purified selectively andfused with an immortal myeloma cell to form a hybridoma cell. Thosecells which secrete the corresponding antigen-specific antibodies arethen determined by selection methods.

In addition to use of hybridoma cells, recombinant preparation of theseantibodies with the desired specificity is also possible after isolationand sequencing. Cells which provide the required posttranslationalmodifications are typically used for this. On the basis of the immunereaction with formation of human anti-mouse antibodies in the humanorganism in the case of native antibodies produced in the mouse (or inother hosts), chimeric, humanized or human antibodies are preferablyprepared here.

After expression, these antibodies, optionally prepared by recombinantmethods, can be employed as agents both in biochemical and molecularbiology research, and in diagnostics and for medical uses.

In medical uses, however, in many cases antibodies can be employeddirectly only with difficulty, since these usually have only a veryshort half-life in vivo and therefore, possibly, cannot reach theirtarget antigen or their target nucleic acid at all. This requires eitherhigh active compound concentrations of the desired antibody, oralternative methods which are suitable for providing large amounts ofantibodies in vivo.

Such methods include, e.g. molecular medicine methods of gene therapyand genetic vaccination which, when used generally in the therapy andprevention of diseases, have considerable effects on medical practice.Both methods are based on the introduction of nucleic acids into cellsor into tissue of the patient and on subsequent processing by the cellsor, respectively, tissue of the information coded by the nucleic acidsintroduced, i.e. expression of the desired polypeptides, e.g.antibodies, in the cells or respectively, the tissue.

The conventional procedure of methods of gene therapy and of geneticvaccination is based on the use of DNA to sluice the required geneticinformation into the cell. Various methods for introducing DNA intocells have been developed in this connection, such as, for example,calcium phosphate transfection, polyprene transfection, protoplastfusion, electroporation, microinjection, lipofection and the use of genecanons, lipofection in particular having emerged as a suitable method.

A further method which has been proposed in particular in the case ofgenetic vaccination methods is the use of DNA viruses as DNA vehicles.Such viruses have the advantage that because of their infectiousproperties a very high transfection rate can be achieved. The virusesused are genetically modified, so that no functional infectiousparticles are formed in the transfected cell. The use of DNA viruses asDNA vehicles, however, has been criticized in recent years because ofthe risk of recombination of non-active viruses to give active viruses.

The use of DNA as an agent in gene therapy and genetic vaccination orfor passive immunization (by passive vaccines), e.g. by using codingsequences for antibodies, may, however, also be less advantageous fromsome points of view. DNA is degraded only relatively slowly in thebloodstream, so that when (foreign) DNA is used as the coding sequencefor a desired protein, a formation of anti-DNA antibodies may occur,which has been confirmed in an animal model in the mouse (Gilkeson etal., J. Clin. Invest. 1995, 95: 1398-1402). The possible persistence of(foreign) DNA in the organism can thus lead to a hyperactivation of theimmune system, which as is known results in splenomegaly in mice(Montheith et al., Anticancer Drug Res. 1997, 12(5): 421-432).Furthermore, (foreign) DNA can interact with the host genome, and inparticular cause mutations by integration into the host genome. Thus,for example, the (foreign) DNA introduced may be inserted into an intactgene, which represents a mutation which can impede or even completelyswitch off the function of the endogenous gene. On the one hand enzymesystems which are vital for the cell may be destroyed by suchintegration events, and on the other hand there is also the danger of atransformation of the cell modified in this way into a degenerated stateif a gene which is decisive for regulation of cell growth is modified bythe integration of the foreign DNA. With the methods to date of genetherapy and genetic vaccination and also of passive immunization, a riskof development of cancer therefore cannot necessarily be ruled out when(foreign) DNA is used. In this context, passive immunization (byso-called “passive vaccines”) is to be strictly differentiated fromso-called active immunization. In active immunization, an antigen(“active vaccine”) is typically administered, after which the organismforms antibodies against this antigen. Active immunization thus createsa permanent immunization of the organism against the particular antigen,which can be associated with the disadvantages described above. Inpassive immunization, in contrast, only an antiserum or the purifiedantibody itself (“passive vaccine”) is administered to the organism. Thecoding sequence for the antibody can likewise be administered, asdescribed above, as a so-called passive vaccine for passiveimmunization.

Summarizing, in the prior art there is an increased demand for and aconsiderable interest in agents which are suitable for employingantibodies effectively in vivo, in particular for providing increasedactive compound amounts of antibodies in vivo, without the riskshitherto associated with the use of DNA.

It is thus an object of the present invention to provide an RNA encodingan antibody or a fragment thereof. In particular, it is an object toprovide a system for expressing an antibody. It is a further object ofthe invention to provide such a system, which allows treatment and/orprophylaxis of a variety of diseases with antibodies in a safe andeffective manner. It is thus a particular object of the presentinvention to provide a composition, in particular a passive vaccine, fortreatment or prophylaxis of a variety of diseases, such as cancer,cardiovascular diseases, infectious diseases, autoimmune diseases, virusdiseases and monogenetic diseases.

The object underlying the present invention is solved by the claimedsubject matter.

The present application is filed together with a sequence listing inelectronic format. The sequence listing is provided as a file entitledCU01P215WO1_Sequence listing.txt, created on Apr. 26, 2017, which is50,982 KB in size. The information contained in the electronic format ofthe sequence listing is incorporated herein by reference in itsentirety.

For the sake of clarity and readability the following definitions areprovided. Any technical feature mentioned for these definitions may beread on each and every embodiment of the invention. Additionaldefinitions and explanations may be specifically provided in the contextof these embodiments.

Adaptive immune response: The adaptive immune response is typicallyunderstood to be an antigen-specific response of the immune system.Antigen specificity allows for the generation of responses that aretailored, for example, to specific pathogens or pathogen-infected cells.The ability to mount these tailored responses is usually maintained inthe body by “memory cells”. Should a pathogen infect the body more thanonce, these specific memory cells are used to quickly eliminate it. Inthis context, the first step of an adaptive immune response is theactivation of naïve antigen-specific T cells or different immune cellsable to induce an antigen-specific immune response by antigen-presentingcells. This occurs in the lymphoid tissues and organs through whichnaïve T cells are constantly passing. The three cell types that mayserve as antigen-presenting cells are dendritic cells, macrophages, andB cells. Each of these cells has a distinct function in eliciting immuneresponses. Dendritic cells may take up antigens by phagocytosis andmacropinocytosis and may become stimulated by contact with e.g. aforeign antigen to migrate to the local lymphoid tissue, where theydifferentiate into mature dendritic cells. Macrophages ingestparticulate antigens such as bacteria and are induced by infectiousagents or other appropriate stimuli to express MHC molecules. The uniqueability of B cells to bind and internalize soluble protein antigens viatheir receptors may also be important to induce T cells. MHC-moleculesare, typically, responsible for presentation of an antigen to T-cells.Therein, presenting the antigen on MHC molecules leads to activation ofT cells, which induces their proliferation and differentiation intoarmed effector T cells. The most important function of effector T cellsis the killing of infected cells by CD8+ cytotoxic T cells and theactivation of macrophages by Th1 cells, which together make upcell-mediated immunity, and the activation of B cells by both Th2 andTh1 cells to produce different classes of antibody, thus driving thehumoral immune response. T cells recognize an antigen by their T cellreceptors which do not recognize and bind the antigen directly, butinstead recognize short peptide fragments e.g. of pathogen-derivedprotein antigens, e.g. so-called epitopes, which are bound to MHCmolecules on the surfaces of other cells.

Adaptive immune system: The adaptive immune system is essentiallydedicated to eliminate or prevent pathogenic growth. It typicallyregulates the adaptive immune response by providing the vertebrateimmune system with the ability to recognize and remember specificpathogens (to generate immunity), and to mount stronger attacks eachtime the pathogen is encountered. The system is highly adaptable becauseof somatic hypermutation (a process of accelerated somatic mutations),and V(D)J recombination (an irreversible genetic recombination ofantigen receptor gene segments). This mechanism allows a small number ofgenes to generate a vast number of different antigen receptors, whichare then uniquely expressed on each individual lymphocyte. Because thegene rearrangement leads to an irreversible change in the DNA of eachcell, all of the progeny (offspring) of such a cell will then inheritgenes encoding the same receptor specificity, including the Memory Bcells and Memory T cells that are the keys to long-lived specificimmunity.

Adjuvant/adjuvant component: An adjuvant or an adjuvant component in thebroadest sense is typically a pharmacological and/or immunological agentthat may modify, e.g. enhance, the effect of other agents, such as adrug or vaccine. It is to be interpreted in a broad sense and refers toa broad spectrum of substances. Typically, these substances are able toincrease the immunogenicity of antigens. For example, adjuvants may berecognized by the innate immune systems and, e.g., may elicit an innateimmune response. “Adjuvants” typically do not elicit an adaptive immuneresponse. Insofar, “adjuvants” do not qualify as antigens. Their mode ofaction is distinct from the effects triggered by antigens resulting inan adaptive immune response.

Antibody: As used herein, the term “antibody” encompasses various formsof antibodies, preferably monoclonal antibodies, including but not beinglimited to whole antibodies, antibodies of any (recombinant or naturallyoccurring) antibody format, human antibodies, chimeric antibodies,humanized antibodies and genetically engineered antibodies (variant ormutant antibodies) as long as the characteristic properties of anantibody are retained. Namely, an antibody recognizes a unique moleculeof an antigen via its variable region. In particular, the antibodymediates this function by binding to the antigen. In particular, theterm “antibody” refers to both, glycosylated and non-glycosylatedimmunoglobulins of any isotype or subclass (preferably IgG). An antibodymay also be derived from an immunoglobulin, however, an antibodytypically comprises an antigen-binding region (of an immunoglobulin)that is in particular able to compete with the “intact” immunoglobulinantibody for specific binding, unless otherwise specified. Preferredexamples of antibodies include monoclonal antibodies, bispecificantibodies, minibodies, domain antibodies, synthetic antibodies,antibody mimetics, chimeric antibodies, humanized antibodies, humanantibodies, antibody fusions, antibody conjugates, single chainantibodies, antibody derivatives, and antibody analogues. Unlessotherwise indicated, the term “antibody” includes, in addition toantibodies comprising two full-length heavy chains and two full-lengthlight chains, derivatives, variants, and antibodies of any formats,which do not comprise two full-length heavy chains and two full-lengthlight chains. In some instances an “antibody” may thus include fewerchains, for example a single chain only. Especially preferred are humanor humanized monoclonal antibodies and/or recombinant antibodies,especially as recombinant human monoclonal antibodies. Particularlypreferred are human IgG-type antibodies.

Human antibody: The term “human antibody”, as used herein, is intendedto include antibodies having variable and constant regions derived fromhuman (germ line) immunoglobulin sequences. In other words, the term“human antibodies” refers to antibodies which have human sequences, thatis to say in the constant regions (if present) and in the variableregions. Human antibodies are well-known in the state of the art (vanDijk, M. A., and van de Winkel, J. G., Curr. Opin. Chem. Biol. 5 (2001)368-374). Human antibodies can also be produced in transgenic animals(e.g., mice) that are capable, upon immunization, of producing a fullrepertoire or a selection of human antibodies in the absence ofendogenous immunoglobulin production. Transfer of the human germ-lineimmunoglobulin gene array in such germ-line mutant mice will result inthe production of human antibodies upon antigen challenge (see, e.g.,Jakobovits, A., et al., Proc. Natl. Acad. Sci. USA 90 (1993) 2551-2555;Jakobovits, A., et al., Nature 362 (1993) 255-258; Bruggemann, M., etal., Year Immunol. 7 (1993) 3340). Human antibodies can also be producedin phage display libraries (Hoogenboom, H. R., and Winter, G., J. Mol.Biol. 227 (1992) 381-388; Marks, J. D., et al., J. Mol. Biol. 222 (1991)581-597). The techniques of Cole et al. and Boerner et al. are alsoavailable for the preparation of human monoclonal antibodies (Cole etal., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, p. 77(1985); and Boerner, P., et al., J. Immunol. 147 (1991) 86-95). Inparticular, the term “human antibody” as used herein also comprisesantibodies of recombinant antibody formats as long as the variableregions (including the hypervariable regions) have human (germ line)immunoglobulin sequences.

Antigen: In the context of the present invention, the term “antigen”typically refers to a substance, which is capable of being recognized bythe immune system, preferably by the adaptive immune system, and whichis capable of eliciting an antigen-specific immune response, e.g. byformation of antibodies and/or antigen-specific T cells as part of anadaptive immune response. Typically, an antigen may be or may comprise apeptide or protein, which may be presented by the MHC to T-cells. In thesense of the present invention an antigen may be the product oftranslation of a provided nucleic acid molecule, preferably an RNAcomprising at least one coding sequence as defined herein. In thiscontext, also fragments, variants and derivatives of an antigen, such asa peptide or a protein, comprising at least one epitope are understoodas antigens.

Artificial nucleic acid molecule: An artificial nucleic acid moleculemay typically be understood to be a nucleic acid molecule, e.g. a DNA oran RNA, that does not occur naturally. In other words, an artificialnucleic acid molecule may be understood as a non-natural nucleic acidmolecule. Such nucleic acid molecule may be non-natural due to itsindividual sequence (which does not occur naturally) and/or due to othermodifications, e.g. structural modifications of nucleotides, which donot occur naturally. An artificial nucleic acid molecule may be a DNAmolecule, an RNA molecule or a hybrid-molecule comprising DNA and RNAportions. Typically, artificial nucleic acid molecules may be designedand/or generated by genetic engineering methods to correspond to adesired artificial sequence of nucleotides (heterologous sequence). Inthis context an artificial sequence is usually a sequence that may notoccur naturally, i.e. it differs from the wild type sequence by at leastone nucleotide. The term “wild type” may be understood as a sequenceoccurring in nature. Further, the term “artificial nucleic acidmolecule” is not restricted to mean “one single molecule” but is,typically, understood to comprise an ensemble of identical molecules.Accordingly, it may relate to a plurality of identical moleculescontained in an aliquot.

Bicistronic RNA, multicistronic RNA: A bicistronic or multicistronic RNAis typically an RNA, preferably an mRNA, that typically may have two(bicistronic) or more (multicistronic) open reading frames (ORF). Anopen reading frame in this context is a sequence of codons that istranslatable into a peptide or protein.

Carrier/polymeric carrier: A carrier in the context of the invention maytypically be a compound that facilitates transport and/or complexationof another compound (cargo). A polymeric carrier is typically a carrierthat is formed of a polymer. A carrier may be associated to its cargo bycovalent or non-covalent interaction. A carrier may transport nucleicacids, e.g. RNA or DNA, to the target cells. The carrier may—for someembodiments—be a cationic component.

Cationic component: The term “cationic component” typically refers to acharged molecule, which is positively charged (cation) at a pH valuetypically from 1 to 9, preferably at a pH value of or below 9 (e.g. from5 to 9), of or below 8 (e.g. from 5 to 8), of or below 7 (e.g. from 5 to7), most preferably at a physiological pH, e.g. from 7.3 to 7.4.Accordingly, a cationic component may be any positively charged compoundor polymer, preferably a cationic peptide or protein, which ispositively charged under physiological conditions, particularly underphysiological conditions in vivo. A “cationic peptide or protein” maycontain at least one positively charged amino acid, or more than onepositively charged amino acid, e.g. selected from Arg, His, Lys or Orn.Accordingly, “polycationic” components are also within the scopeexhibiting more than one positive charge under the conditions given.

5′-cap: A 5′-cap is an entity, typically a modified nucleotide entity,which generally “caps” the 5′-end of a mature mRNA. A 5′-cap maytypically be formed by a modified nucleotide, particularly by aderivative of a guanine nucleotide. Preferably, the 5′-cap is linked tothe 5′-terminus via a 5′-5′-triphosphate linkage. A 5′-cap may bemethylated, e.g. m7GpppN, wherein N is the terminal 5′ nucleotide of thenucleic acid carrying the 5′-cap, typically the 5′-end of an RNA.Further examples of 5′cap structures include glyceryl, inverted deoxyabasic residue (moiety), 4′,5′ methylene nucleotide,1-(beta-D-erythrofuranosyl) nucleotide, 4′-thio nucleotide, carbocyclicnucleotide, 1,5-anhydrohexitol nucleotide, L-nucleotides,alpha-nucleotide, modified base nucleotide, threo-pentofuranosylnucleotide, acyclic 3′,4′-seco nucleotide, acyclic 3,4-dihydroxybutylnucleotide, acyclic 3,5 dihydroxypentyl nucleotide, 3′-3′-invertednucleotide moiety, 3′-3′-inverted abasic moiety, 3′-2′-invertednucleotide moiety, 3′-2′-inverted abasic moiety, 1,4-butanediolphosphate, 3′-phosphoramidate, hexylphosphate, aminohexyl phosphate,3′-phosphate, 3′phosphorothioate, phosphorodithioate, or bridging ornon-bridging methylphosphonate moiety.

Cellular immunity/cellular immune response: Cellular immunity relatestypically to the activation of macrophages, natural killer cells (NK),antigen-specific cytotoxic T-lymphocytes, and the release of variouscytokines in response to an antigen. In more general terms, cellularimmunity is not based on antibodies, but on the activation of cells ofthe immune system. Typically, a cellular immune response may becharacterized e.g. by activating antigen-specific cytotoxicT-lymphocytes that are able to induce apoptosis in cells, e.g. specificimmune cells like dendritic cells or other cells, displaying epitopes offoreign antigens on their surface. Such cells may be virus-infected orinfected with intracellular bacteria, or cancer cells displayingantibodies. Further characteristics may be activation of macrophages andnatural killer cells, enabling them to destroy pathogens and stimulationof cells to secrete a variety of cytokines that influence the functionof other cells involved in adaptive immune responses and innate immuneresponses.

DNA: DNA is the usual abbreviation for deoxy-ribonucleic acid. It is anucleic acid molecule, i.e. a polymer consisting of nucleotides. Thesenucleotides are usually deoxy-adenosine-monophosphate,deoxy-thymidine-monophosphate, deoxy-guanosine-monophosphate anddeoxy-cytidine-monophosphate monomers which are—by themselves—composedof a sugar moiety (deoxyribose), a base moiety and a phosphate moiety,and polymerise by a characteristic backbone structure. The backbonestructure is, typically, formed by phosphodiester bonds between thesugar moiety of the nucleotide, i.e. deoxyribose, of a first and aphosphate moiety of a second, adjacent monomer. The specific order ofthe monomers, i.e. the order of the bases linked to thesugar/phosphate-backbone, is called the DNA sequence. DNA may be singlestranded or double stranded. In the double stranded form, thenucleotides of the first strand typically hybridize with the nucleotidesof the second strand, e.g. by KT-base-pairing and G/C-base-pairing.

Epitope: In the context of the present invention, the term ‘epitope’typically refers to a fragment of an antigen or a variant of an antigen,wherein said fragment is presented by an MHC complex. Such a fragmentcomprising or consisting of an epitope as used herein may typicallycomprise from about 5 to about 20 amino acids. An epitope may also bereferred to herein as ‘antigen determinant’. Epitopes can bedistinguished in T cell epitopes and B cell epitopes. T cell epitopes orparts of the proteins in the context of the present invention maycomprise fragments preferably having a length of about 6 to about 20 oreven more amino acids, e.g. fragments as processed and presented by MHCclass I molecules, preferably having a length of about 8 to about 10amino acids, e.g. 8, 9, or 10, (or even 11, or 12 amino acids), orfragments as processed and presented by MHC class II molecules,preferably having a length of about 13 or more amino acids, e.g. 13, 14,15, 16, 17, 18, 19, 20 or even more amino acids, wherein these fragmentsmay be selected from any part of the amino acid sequence. Thesefragments are typically recognized by T cells in form of a complexconsisting of the peptide fragment and an MHC molecule, i.e. thefragments are typically not recognized in their native form. B cellepitopes are typically fragments located on the outer surface of(native) protein or peptide antigens as defined herein, preferablyhaving 5 to 15 amino acids, more preferably having 5 to 12 amino acids,even more preferably having 6 to 9 amino acids, which may be recognizedby antibodies, i.e. in their native form. Such epitopes of proteins orpeptides may furthermore be selected from any of the herein mentionedvariants of such proteins or peptides. In this context, antigenicdeterminants can be conformational or discontinuous epitopes, which arecomposed of segments of the proteins or peptides as defined herein thatare discontinuous in the amino acid sequence of the proteins or peptidesas defined herein but are brought together in the three-dimensionalstructure or continuous or linear epitopes, which are composed of asingle polypeptide chain.

Fragment of a sequence: A fragment of a sequence may typically be ashorter portion of a full-length sequence of e.g. a nucleic acidmolecule or an amino acid sequence. Accordingly, a fragment, typically,consists of a sequence that is identical to the corresponding stretchwithin the full-length sequence. A preferred fragment of a sequence inthe context of the present invention, consists of a continuous stretchof entities, such as nucleotides or amino acids corresponding to acontinuous stretch of entities in the molecule the fragment is derivedfrom, which represents at least 20%, preferably at least 30%, morepreferably at least 40%, more preferably at least 50%, even morepreferably at least 60%, even more preferably at least 70%, and mostpreferably at least 80% of the total (i.e. full-length) molecule fromwhich the fragment is derived.

G/C modified: A G/C-modified nucleic acid may typically be a nucleicacid, preferably an artificial nucleic acid molecule as defined herein,based on a modified wild-type sequence comprising a preferably increasednumber of guanosine and/or cytosine nucleotides as compared to thewild-type sequence. Such an increased number may be generated bysubstitution of codons containing adenosine or thymidine nucleotides bycodons containing guanosine or cytosine nucleotides. If the enriched G/Ccontent occurs in a coding region of DNA or RNA, it makes use of thedegeneracy of the genetic code. Accordingly, the codon substitutionspreferably do not alter the encoded amino acid residues, but exclusivelyincrease the G/C content of the nucleic acid molecule. As used herein,the term ‘G/C modification’ comprises, in particular, the modificationsof the number of guanosine and/or cytosine nucleotides in the RNAaccording to the invention, such as GC optimization of sequences,adaptation of sequences to human codon usage, codon optimization orC-optimization of sequences.

Gene therapy: Gene therapy may typically be understood to mean atreatment of a patient's body or isolated elements of a patient's body,for example isolated tissues/cells, by nucleic acids encoding a peptideor protein. It typically may comprise at least one of the steps of a)administration of a nucleic acid, preferably an RNA as defined herein,directly to the patient—by whatever administration route—or in vitro toisolated cells/tissues of the patient, which results in transfection ofthe patient's cells either in vivo/ex vivo or in vitro; b) transcriptionand/or translation of the introduced nucleic acid molecule; andoptionally c) re-administration of isolated, transfected cells to thepatient, if the nucleic acid has not been administered directly to thepatient.

Genetic vaccination: Genetic vaccination may typically be understood tobe vaccination by administration of a nucleic acid molecule encoding anantigen or an immunogen or fragments thereof. The nucleic acid moleculemay be administered to a subject's body or to isolated cells of asubject. Upon transfection of certain cells of the body or upontransfection of the isolated cells, the antigen or immunogen may beexpressed by those cells and subsequently presented to the immunesystem, eliciting an adaptive, i.e. antigen-specific immune response.Accordingly, genetic vaccination typically comprises at least one of thesteps of a) administration of a nucleic acid, preferably an artificialnucleic acid molecule as defined herein, to a subject, preferably apatient, or to isolated cells of a subject, preferably a patient, whichusually results in transfection of the subject's cells either in vivo orin vitro; b) transcription and/or translation of the introduced nucleicacid molecule; and optionally c) re-administration of isolated,transfected cells to the subject, preferably the patient, if the nucleicacid has not been administered directly to the patient.

Heterologous sequence: Two sequences are typically understood to be‘heterologous’ if they are not derivable from the same gene. I.e.,although heterologous sequences may be derivable from the same organism,they naturally (in nature) do not occur in the same nucleic acidmolecule, such as in the same mRNA.

Humoral immunity/humoral immune response: Humoral immunity referstypically to antibody production and optionally to accessory processesaccompanying antibody production. A humoral immune response may betypically characterized, e.g., by Th2 activation and cytokineproduction, germinal center formation and isotype switching, affinitymaturation and memory cell generation. Humoral immunity also typicallymay refer to the effector functions of antibodies, which includepathogen and toxin neutralization, classical complement activation, andopsonin promotion of phagocytosis and pathogen elimination.

Immunogen: In the context of the present invention, an immunogen may betypically understood to be a compound that is able to stimulate animmune response. Preferably, an immunogen is a peptide, polypeptide, orprotein. In a particularly preferred embodiment, an immunogen in thesense of the present invention is the product of translation of aprovided nucleic acid molecule, preferably an artificial nucleic acidmolecule as defined herein. Typically, an immunogen elicits at least anadaptive immune response.

Immunostimulatory composition: In the context of the invention, animmunostimulatory composition may be typically understood to be acomposition containing at least one component which is able to induce animmune response or from which a component, which is able to induce animmune response, is derivable. Such immune response may be preferably aninnate immune response or a combination of an adaptive and an innateimmune response. Preferably, an immunostimulatory composition in thecontext of the invention contains at least one artificial nucleic acidmolecule, more preferably an RNA, for example an mRNA molecule. Theimmunostimulatory component, such as the mRNA may be complexed with asuitable carrier. Thus, the immunostimulatory composition may comprisean mRNA/carrier-complex. Furthermore, the immunostimulatory compositionmay comprise an adjuvant and/or a suitable vehicle for theimmunostimulatory component, such as the mRNA.

Immune response: An immune response may typically be a specific reactionof the adaptive immune system to a particular antigen (so calledspecific or adaptive immune response) or an unspecific reaction of theinnate immune system (so called unspecific or innate immune response),or a combination thereof.

Immune system: The immune system may protect organisms from infection.If a pathogen succeeds in passing a physical barrier of an organism andenters this organism, the innate immune system provides an immediate,but non-specific response. If pathogens evade this innate response,vertebrates possess a second layer of protection, the adaptive immunesystem. Here, the immune system adapts its response during an infectionto improve its recognition of the pathogen. This improved response isthen retained after the pathogen has been eliminated, in the form of animmunological memory, and allows the adaptive immune system to mountfaster and stronger attacks each time this pathogen is encountered.According to this, the immune system comprises the innate and theadaptive immune system. Each of these two parts typically contains socalled humoral and cellular components.

Immunostimulatory RNA: An immunostimulatory RNA (isRNA) in the contextof the invention may typically be an RNA that is able to induce aninnate immune response. It usually does not have an open reading frameand thus does not provide a peptide-antigen or immunogen but elicits animmune response e.g. by binding to a specific kind of Toll-like-receptor(TLR) or other suitable receptors. However, of course also mRNAs havingan open reading frame and coding for a peptide/protein may induce aninnate immune response and, thus, may be immunostimulatory RNAs.

Innate immune system: The innate immune system, also known asnon-specific (or unspecific) immune system, typically comprises thecells and mechanisms that defend the host from infection by otherorganisms in a non-specific manner. This means that the cells of theinnate system may recognize and respond to pathogens in a generic way,but unlike the adaptive immune system, it does not confer long-lastingor protective immunity to the host. The innate immune system may be,e.g., activated by ligands of Toll-like receptors (TLRs) or otherauxiliary substances such as lipopolysaccharides, TNF-alpha, CD40ligand, or cytokines, monokines, lymphokines, interleukins orchemokines, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10,IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20,IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, IL-29, IL-30,IL-31, IL-32, IL-33, IFN-alpha, IFN-beta, IFN-gamma, GM-CSF, G-CSF,M-CSF, LT-beta, TNF-alpha, growth factors, and hGH, a ligand of humanToll-like receptor TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9,TLR10, a ligand of murine Toll-like receptor TLR1, TLR2, TLR3, TLR4,TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12 or TLR13, a ligand ofa NOD-like receptor, a ligand of a RIG-I like receptor, animmunostimulatory nucleic acid, an immunostimulatory RNA (isRNA), aCpG-DNA, an antibacterial agent, or an anti-viral agent. Thepharmaceutical composition according to the present invention maycomprise one or more such substances. Typically, a response of theinnate immune system includes recruiting immune cells to sites ofinfection, through the production of chemical factors, includingspecialized chemical mediators, called cytokines; activation of thecomplement cascade; identification and removal of foreign substancespresent in organs, tissues, the blood and lymph, by specialized whiteblood cells; activation of the adaptive immune system; and/or acting asa physical and chemical barrier to infectious agents.

Cloning site: A cloning site is typically understood to be a segment ofa nucleic acid molecule, which is suitable for insertion of a nucleicacid sequence, e.g., a nucleic acid sequence comprising an open readingframe. Insertion may be performed by any molecular biological methodknown to the one skilled in the art, e.g. by restriction and ligation. Acloning site typically comprises one or more restriction enzymerecognition sites (restriction sites). These one or more restrictionssites may be recognized by restriction enzymes which cleave the DNA atthese sites. A cloning site which comprises more than one restrictionsite may also be termed a multiple cloning site (MCS) or a polylinker.

Nucleic acid molecule: A nucleic acid molecule is a molecule comprising,preferably consisting of nucleic acid components. The term nucleic acidmolecule preferably refers to DNA or RNA molecules. It is preferablyused synonymous with the term “polynucleotide”. Preferably, a nucleicacid molecule is a polymer comprising or consisting of nucleotidemonomers, which are covalently linked to each other byphosphodiester-bonds of a sugar/phosphate-backbone. The term “nucleicacid molecule” also encompasses modified nucleic acid molecules, such asbase-modified, sugar-modified or backbone-modified etc. DNA or RNAmolecules.

Open reading frame: An open reading frame (ORF) in the context of theinvention may typically be a sequence of several nucleotide triplets,which may be translated into a peptide or protein. An open reading framepreferably contains a start codon, i.e. a combination of threesubsequent nucleotides coding usually for the amino acid methionine(ATG), at its 5′-end and a subsequent region, which usually exhibits alength which is a multiple of 3 nucleotides. An ORF is preferablyterminated by a stop-codon (e.g., TAA, TAG, TGA). Typically, this is theonly stop-codon of the open reading frame. Thus, an open reading framein the context of the present invention is preferably a nucleotidesequence, consisting of a number of nucleotides that may be divided bythree, which starts with a start codon (e.g. ATG) and which preferablyterminates with a stop codon (e.g., TAA, TGA, or TAG). The open readingframe may be isolated or it may be incorporated in a longer nucleic acidsequence, for example in a vector or an mRNA. An open reading frame mayalso be termed “(protein) coding region” or, preferably, “codingsequence”.

Peptide: A peptide or polypeptide is typically a polymer of amino acidmonomers, linked by peptide bonds. It typically contains less than 50monomer units. Nevertheless, the term peptide is not a disclaimer formolecules having more than 50 monomer units. Long peptides are alsocalled polypeptides, typically having between 50 and 600 monomericunits.

Pharmaceutically effective amount: A pharmaceutically effective amountin the context of the invention is typically understood to be an amountthat is sufficient to induce a pharmaceutical effect, such as an immuneresponse, altering a pathological level of an expressed peptide orprotein, or substituting a lacking gene product, e.g., in case of apathological situation.

Protein: A protein typically comprises one or more peptides orpolypeptides. A protein is typically folded into 3-dimensional form,which may be required for the protein to exert its biological function.

Poly(A) sequence: A poly(A) sequence, also called poly(A) tail or3′-poly(A) tail, is typically understood to be a sequence of adenosinenucleotides, e.g., of up to about 400 adenosine nucleotides, e.g. fromabout 5 to about 400, preferably from about 10 to about 200, morepreferably from about 10 to about 100, even more preferably from about40 to about 80, most preferably from about 50 to about 70 adenosinenucleotides. A poly(A) sequence is typically located at the 3′end of anmRNA. In the context of the present invention, a poly(A) sequence may belocated within an mRNA or any other nucleic acid molecule, such as,e.g., in a vector, for example, in a vector serving as template for thegeneration of an RNA, preferably an mRNA, e.g., by transcription of thevector.

Polyadenylation: Polyadenylation is typically understood to be theaddition of a poly(A) sequence to a nucleic acid molecule, such as anRNA molecule, e.g. to a premature mRNA. Polyadenylation may be inducedby a so-called polyadenylation signal. This signal is preferably locatedwithin a stretch of nucleotides at the 3′-end of a nucleic acidmolecule, such as an RNA molecule, to be polyadenylated. Apolyadenylation signal typically comprises a hexamer consisting ofadenine and uracil/thymine nucleotides, preferably the hexamer sequenceAAUAAA. Other sequences, preferably hexamer sequences, are alsoconceivable. Polyadenylation typically occurs during processing of apre-mRNA (also called premature-mRNA). Typically, RNA maturation (frompre-mRNA to mature mRNA) comprises the step of polyadenylation.

Restriction site: A restriction site, also termed restriction enzymerecognition site, is a nucleotide sequence recognized by a restrictionenzyme. A restriction site is typically a short, preferably palindromicnucleotide sequence, e.g. a sequence comprising 4 to 8 nucleotides. Arestriction site is preferably specifically recognized by a restrictionenzyme. The restriction enzyme typically cleaves a nucleotide sequencecomprising a restriction site at this site. In a double-strandednucleotide sequence, such as a double-stranded DNA sequence, therestriction enzyme typically cuts both strands of the nucleotidesequence.

RNA, mRNA: RNA is the usual abbreviation for ribonucleic-acid. It is anucleic acid molecule, i.e. a polymer consisting of nucleotides. Thesenucleotides are usually adenosine-monophosphate, uridine-monophosphate,guanosine-monophosphate and cytidine-monophosphate monomers which areconnected to each other along a so-called backbone. The backbone isformed by phosphodiester bonds between the sugar, i.e. ribose, of afirst and a phosphate moiety of a second, adjacent monomer. The specificsuccession of the monomers is called the RNA-sequence. Usually RNA maybe obtainable by transcription of a DNA-sequence, e.g., inside a cell.In eukaryotic cells, transcription is typically performed inside thenucleus or the mitochondria. In vivo, transcription of DNA usuallyresults in the so-called premature RNA which has to be processed intoso-called messenger-RNA, usually abbreviated as mRNA. Processing of thepremature RNA, e.g. in eukaryotic organisms, comprises a variety ofdifferent posttranscriptional-modifications such as splicing,5′-capping, polyadenylation, export from the nucleus or the mitochondriaand the like. The sum of these processes is also called maturation ofRNA. The mature messenger RNA usually provides the nucleotide sequencethat may be translated into an amino-acid sequence of a particularpeptide or protein. Typically, a mature mRNA comprises a 5′-cap, a5′-UTR, an open reading frame, a 3′-UTR and a poly(A) sequence. Asidefrom messenger RNA, several non-coding types of RNA exist which may beinvolved in regulation of transcription and/or translation.

Sequence of a nucleic acid molecule: The sequence of a nucleic acidmolecule is typically understood to be the particular and individualorder, i.e. the succession of its nucleotides. The sequence of a proteinor peptide is typically understood to be the order, i.e. the successionof its amino acids.

Sequence identity: Two or more sequences are identical if they exhibitthe same length and order of nucleotides or amino acids. The percentageof identity typically describes the extent to which two sequences areidentical, i.e. it typically describes the percentage of nucleotidesthat correspond in their sequence position with identical nucleotides ofa reference-sequence. For determination of the degree of identity, thesequences to be compared are considered to exhibit the same length, i.e.the length of the longest sequence of the sequences to be compared. Thismeans that a first sequence consisting of 8 nucleotides is 80% identicalto a second sequence consisting of 10 nucleotides comprising the firstsequence. In other words, in the context of the present invention,identity of sequences preferably relates to the percentage ofnucleotides of a sequence which have the same position in two or moresequences having the same length. Gaps are usually regarded asnon-identical positions, irrespective of their actual position in analignment.

Stabilized nucleic acid molecule: A stabilized nucleic acid molecule isa nucleic acid molecule, preferably a DNA or RNA molecule that ismodified such, that it is more stable to disintegration or degradation,e.g., by environmental factors or enzymatic digest, such as by an exo-or endonuclease degradation, than the nucleic acid molecule without themodification. Preferably, a stabilized nucleic acid molecule in thecontext of the present invention is stabilized in a cell, such as aprokaryotic or eukaryotic cell, preferably in a mammalian cell, such asa human cell. The stabilization effect may also be exerted outside ofcells, e.g. in a buffer solution etc., for example, in a manufacturingprocess for a pharmaceutical composition comprising the stabilizednucleic acid molecule.

Transfection: The term “transfection” refers to the introduction ofnucleic acid molecules, such as DNA or RNA (e.g. mRNA) molecules, intocells, preferably into eukaryotic cells. In the context of the presentinvention, the term “transfection” encompasses any method known to theskilled person for introducing nucleic acid molecules into cells,preferably into eukaryotic cells, such as into mammalian cells. Suchmethods encompass, for example, electroporation, lipofection, e.g. basedon cationic lipids and/or liposomes, calcium phosphate precipitation,nanoparticle based transfection, virus based transfection, ortransfection based on cationic polymers, such as DEAE-dextran orpolyethylenimine etc. Preferably, the introduction is non-viral.

Vaccine: A vaccine is typically understood to be a prophylactic ortherapeutic material providing at least one antigen, preferably animmunogen. The antigen or immunogen may be derived from any materialthat is suitable for vaccination. For example, the antigen or immunogenmay be derived from a pathogen, such as from bacteria or virus particlesetc., or from a tumor or cancerous tissue. The antigen or immunogenstimulates the body's adaptive immune system to provide an adaptiveimmune response.

Vector: The term “vector” refers to a nucleic acid molecule, preferablyto an artificial nucleic acid molecule. A vector in the context of thepresent invention is suitable for incorporating or harboring a desirednucleic acid sequence, such as a nucleic acid sequence comprising anopen reading frame. Such vectors may be storage vectors, expressionvectors, cloning vectors, transfer vectors etc. A storage vector is avector, which allows the convenient storage of a nucleic acid molecule,for example, of an mRNA molecule. Thus, the vector may comprise asequence corresponding, e.g., to a desired mRNA sequence or a partthereof, such as a sequence corresponding to the coding sequence and the3′-UTR of an mRNA. An expression vector may be used for production ofexpression products such as RNA, e.g. mRNA, or peptides, polypeptides orproteins. For example, an expression vector may comprise sequencesneeded for transcription of a sequence stretch of the vector, such as apromoter sequence, e.g. an RNA polymerase promoter sequence. A cloningvector is typically a vector that contains a cloning site, which may beused to incorporate nucleic acid sequences into the vector. A cloningvector may be, e.g., a plasmid vector or a bacteriophage vector. Atransfer vector may be a vector, which is suitable for transferringnucleic acid molecules into cells or organisms, for example, viralvectors. A vector in the context of the present invention may be, e.g.,an RNA vector or a DNA vector. Preferably, a vector is a DNA molecule.Preferably, a vector in the sense of the present application comprises acloning site, a selection marker, such as an antibiotic resistancefactor, and a sequence suitable for multiplication of the vector, suchas an origin of replication. Preferably, a vector in the context of thepresent application is a plasmid vector.

Vehicle: A vehicle is typically understood to be a material that issuitable for storing, transporting, and/or administering a compound,such as a pharmaceutically active compound. For example, it may be aphysiologically acceptable liquid, which is suitable for storing,transporting, and/or administering a pharmaceutically active compound.

3′-untranslated region (3′-UTR): Generally, the term “3′-UTR” refers toa part of the artificial nucleic acid molecule, which is located 3′(i.e. “downstream”) of an open reading frame and which is not translatedinto protein. Typically, a 3′-UTR is the part of an mRNA which islocated between the protein coding region (open reading frame (ORF) orcoding sequence (CDS)) and the poly(A) sequence of the mRNA. In thecontext of the invention, the term 3′-UTR may also comprise elements,which are not encoded in the template, from which an RNA is transcribed,but which are added after transcription during maturation, e.g. apoly(A) sequence. A 3′-UTR of the mRNA is not translated into an aminoacid sequence. The 3′-UTR sequence is generally encoded by the gene,which is transcribed into the respective mRNA during the gene expressionprocess. The genomic sequence is first transcribed into pre-mature mRNA,which comprises optional introns. The pre-mature mRNA is then furtherprocessed into mature mRNA in a maturation process. This maturationprocess comprises the steps of 5′capping, splicing the pre-mature mRNAto excise optional introns and modifications of the 3′-end, such aspolyadenylation of the 3′-end of the pre-mature mRNA and optionalendo-/or exonuclease cleavages etc. In the context of the presentinvention, a 3′-UTR corresponds to the sequence of a mature mRNA, whichis located between the stop codon of the protein coding region,preferably immediately 3′ to the stop codon of the protein codingregion, and the poly(A) sequence of the mRNA. The term “corresponds to”means that the 3′-UTR sequence may be an RNA sequence, such as in themRNA sequence used for defining the 3′-UTR sequence, or a DNA sequence,which corresponds to such RNA sequence. In the context of the presentinvention, the term “a 3′-UTR of a gene”, such as “a 3′-UTR of aribosomal protein gene”, is the sequence, which corresponds to the3′-UTR of the mature mRNA derived from this gene, i.e. the mRNA obtainedby transcription of the gene and maturation of the pre-mature mRNA. Theterm “3′-UTR of a gene” encompasses the DNA sequence and the RNAsequence (both sense and antisense strand and both mature and immature)of the 3′-UTR.

5′-untranslated region (5′-UTR): A 5′-UTR is typically understood to bea particular section of messenger RNA (mRNA). It is located 5′ of theopen reading frame of the mRNA. Typically, the 5′-UTR starts with thetranscriptional start site and ends one nucleotide before the startcodon of the open reading frame. The 5′-UTR may comprise elements forcontrolling gene expression, also called regulatory elements. Suchregulatory elements may be, for example, ribosomal binding sites. The5′-UTR may be post-transcriptionally modified, for example by additionof a 5′-CAP. In the context of the present invention, a 5′-UTRcorresponds to the sequence of a mature mRNA, which is located betweenthe 5′-CAP and the start codon. Preferably, the 5′-UTR corresponds tothe sequence, which extends from a nucleotide located 3′ to the 5′-CAP,preferably from the nucleotide located immediately 3′ to the 5′-CAP, toa nucleotide located 5′ to the start codon of the protein coding region,preferably to the nucleotide located immediately 5′ to the start codonof the protein coding region. The nucleotide located immediately 3′ tothe 5′-CAP of a mature mRNA typically corresponds to the transcriptionalstart site. The term “corresponds to” means that the 5′-UTR sequence maybe an RNA sequence, such as in the mRNA sequence used for defining the5′-UTR sequence, or a DNA sequence, which corresponds to such RNAsequence. In the context of the present invention, the term “a 5′-UTR ofa gene” is the sequence, which corresponds to the 5′-UTR of the maturemRNA derived from this gene, i.e. the mRNA obtained by transcription ofthe gene and maturation of the pre-mature mRNA. The term “5′-UTR of agene” encompasses the DNA sequence and the RNA sequence of the 5′-UTR.By the inventive embodiments such a 5′-UTR may be provided 5′-terminalto the coding sequence. Its length is typically less than 500, 400, 300,250 or less than 200 nucleotides. In other embodiments its length may bein the range of at least 10, 20, 30 or 40, preferably up to 100 or 150,nucleotides.

5′Terminal Oligopyrimidine Tract (TOP): The 5′terminal oligopyrimidinetract (TOP) is typically a stretch of pyrimidine nucleotides located inthe 5′ terminal region of a nucleic acid molecule, such as the 5′terminal region of certain mRNA molecules or the 5′ terminal region of afunctional entity, e.g. the transcribed region, of certain genes. Thesequence starts with a cytidine, which usually corresponds to thetranscriptional start site, and is followed by a stretch of usuallyabout 3 to 30 pyrimidine nucleotides. For example, the TOP may comprise3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22,23, 24, 25, 26, 27, 28, 29, 30 or even more nucleotides. The pyrimidinestretch and thus the 5′ TOP ends one nucleotide 5′ to the first purinenucleotide located downstream of the TOP. Messenger RNA that contains a5′terminal oligopyrimidine tract is often referred to as TOP mRNA.Accordingly, genes that provide such messenger RNAs are referred to asTOP genes. TOP sequences have, for example, been found in genes andmRNAs encoding peptide elongation factors and ribosomal proteins.

TOP motif: In the context of the present invention, a TOP motif is anucleic acid sequence which corresponds to a 5′TOP as defined above.Thus, a TOP motif in the context of the present invention is preferablya stretch of pyrimidine nucleotides having a length of 3-30 nucleotides.Preferably, the TOP-motif consists of at least 3 pyrimidine nucleotides,preferably at least 4 pyrimidine nucleotides, preferably at least 5pyrimidine nucleotides, more preferably at least 6 nucleotides, morepreferably at least 7 nucleotides, most preferably at least 8 pyrimidinenucleotides, wherein the stretch of pyrimidine nucleotides preferablystarts at its 5′end with a cytosine nucleotide. In TOP genes and TOPmRNAs, the TOP-motif preferably starts at its 5′end with thetranscriptional start site and ends one nucleotide 5′ to the first purinresidue in said gene or mRNA. A TOP motif in the sense of the presentinvention is preferably located at the 5′end of a sequence, whichrepresents a 5′UTR, or at the 5′end of a sequence, which codes for a5′UTR. Thus, preferably, a stretch of 3 or more pyrimidine nucleotidesis called “TOP motif” in the sense of the present invention if thisstretch is located at the 5′end of a respective sequence, such as theartificial nucleic acid molecule, the 5′UTR element of the artificialnucleic acid molecule, or the nucleic acid sequence which is derivedfrom the 5′UTR of a TOP gene as described herein. In other words, astretch of 3 or more pyrimidine nucleotides, which is not located at the5′-end of a 5′UTR or a 5′UTR element but anywhere within a 5′UTR or a5′UTR element, is preferably not referred to as “TOP motif”.

TOP gene: TOP genes are typically characterised by the presence of a 5′terminal oligopyrimidine tract. Furthermore, most TOP genes arecharacterized by a growth-associated translational regulation. However,also TOP genes with a tissue specific translational regulation areknown. As defined above, the 5′UTR of a TOP gene corresponds to thesequence of a 5′UTR of a mature mRNA derived from a TOP gene, whichpreferably extends from the nucleotide located 3′ to the 5′-CAP to thenucleotide located 5′ to the start codon. A 5′UTR of a TOP genetypically does not comprise any start codons, preferably no upstreamAUGs (uAUGs) or upstream open reading frames (uORFs). Therein, upstreamAUGs and upstream open reading frames are typically understood to beAUGs and open reading frames that occur 5′ of the start codon (AUG) ofthe open reading frame that should be translated. The 5′UTRs of TOPgenes are generally rather short. The lengths of 5′UTRs of TOP genes mayvary between 20 nucleotides up to 500 nucleotides, and are typicallyless than about 200 nucleotides, preferably less than about 150nucleotides, more preferably less than about 100 nucleotides. Exemplary5′UTRs of TOP genes in the sense of the present invention are thenucleic acid sequences extending from the nucleotide at position 5 tothe nucleotide located immediately 5′ to the start codon (e.g. the ATG)in the sequences according to SEQ ID NOs: 1-1363 of the patentapplication WO2013/143700, whose disclosure is incorporated herewith byreference. In this context, a particularly preferred fragment of a 5′UTRof a TOP gene is a 5′UTR of a TOP gene lacking the 5′TOP motif. Theterms “5′UTR of a TOP gene” or “5′-TOP UTR” preferably refer to the5′UTR of a naturally occurring TOP gene.

RNA Encoding an Antibody or a Fragment Thereof

In a first aspect, the present invention provides an RNA comprising atleast one coding sequence encoding an antibody, or a fragment or variantof an antibody.

As used herein, the term “antibody” refers to antibodies of any antibodyformat. Typically, an antibody recognizes (and binds to) an antigen. Tothis end, an antibody usually comprises at least one antigen-bindingsite, which is also referred to as “paratope” and which recognizes (andbinds to) an epitope on the antigen. A paratope typically comprises aset of complementary determining regions (CDRs) and usually containsparts of the light chain and parts of the heavy chain of the antibody.For example, a paratope of native IgG comprises three CDRs of the heavychain (CDRH1, CDRH2 and CDRH3) and three CDRs of the light chain (CDRL1,CDRL2, and CDRL3). The CDRs of an antibody are arranged in theantibody's variable region: CDRH1, CDRH2 and CDRH3 in the heavy chainvariable region (V_(H)) and CDRL1, CDRL2, and CDRL3 in the light chainvariable region (V_(L)). In addition, an antibody may comprise aconstant region (on heavy and light chain: C_(H) and C_(L),respectively). In native IgG the heavy chain constant region comprisesthree domains (CH1, CH2 and CH3), whereas the light chain constantregion comprises one domain only (see also FIG. 1 ). Accordingly, anantibody is typically an immunoglobulin or is derived from animmunoglobulin. An antibody may fulfil different functions byrecognizing (and binding to) an antigen, such as neutralization,agglutination, precipitation and/or complement activation. Neutralizingantibodies typically block parts of the surface of a bacterial cell orvirion to render its attack ineffective. In agglutination antibodies“glue together” (foreign) cells into clumps that are attractive targetsfor phagocytosis. In precipitation antibodies “glue together”serum-soluble antigens, forcing them to precipitate out of solution inclumps that are attractive targets for phagocytosis. In complementactivation antibodies that are latched onto a (foreign) cell encouragecomplement to attack it with a membrane attack complex, thereby leadingto lysis of the (foreign) cell or to encouragement of inflammation bychemotactically attracting inflammatory cells.

In the context of the present invention, an “RNA comprising at least onecoding sequence encoding an antibody, or a fragment or variant of anantibody” includes any RNA which encodes an antibody or a fragment orvariant of an antibody. More generally, the RNA of the present inventioncontains at least one coding region, wherein the at least one codingregion codes for at least one antibody or a fragment or variant of anantibody. If more than one coding region is contained in the RNAmolecule of the invention, the second, third etc. coding region may codefor other peptides/proteins and/or may code for antibodies or fragmentsor variants thereof as well, which may be the same or distinct from thefirst antibody coding region. In a preferred embodiment, the inventiveRNA contains at least two coding regions, all of them coding foridentical or distinct antibodies or fragments or variants thereof. Forexample, distinct fragments of an antibody may be encoded by differentcoding regions on the same RNA molecule. In still another embodiment ofthe present invention, an inventive RNA may code for more than oneantibody or a fragment or variant of an antibody within the same codingregion. In summary, the inventive RNA may be mono-, bi- ormulticistronic.

The RNA according to the invention can be single-stranded ordouble-stranded, linear or circular, or in particular in the form ofmRNA. The RNA according to the invention is particularly preferably inthe form of single-stranded RNA, even more preferably in the form ofmRNA.

The RNA according to the invention preferably has a length of from 50 to15,000 nucleotides, more preferably a length of from 50 to 10,000nucleotides, even more preferably a length of from 500 to 10,000nucleotides and most preferably a length of from 500 to 7,000, 500 to5,000 or 700 to 3,000 nucleotides.

In the context of the present invention, the antibodies coded by the RNAaccording to the invention can be chosen from all antibodies, e.g. fromall antibodies which are generated by recombinant methods or arenaturally occurring and are known to a person skilled in the art fromthe prior art, in particular antibodies which are (can be) employed fortherapeutic purposes or for diagnostic or for research purposes or havebeen found with particular diseases, e.g. cancer diseases, infectiousdiseases etc.

In the context of the present invention, antibodies or fragments orvariants thereof, which are encoded by the RNA according to theinvention, typically include all antibodies or fragments or variantsthereof which are known to a person skilled in the art, e.g. naturallyoccurring antibodies or antibodies generated in a host organism byimmunization, antibodies or fragments or variants thereof prepared byrecombinant methods which have been isolated and identified fromnaturally occurring antibodies or antibodies generated in a hostorganism by (conventional) immunization or have been generated with theaid of molecular biology methods, as well as chimeric antibodies orfragments or variants thereof, human antibodies or fragments or variantsthereof, humanized antibodies or fragments or variants thereof,bispecific antibodies or fragments or variants thereof, and intrabodiesor fragments or variants thereof, i.e. antibodies expressed in cells andpossibly localized in particular cell compartments.

RNA molecules according to the invention can also be prepared on thebasis of polyclonal antibodies or fragments or variants thereof or, asan antibody-coding RNA cocktail, can have a polyclonal character. In thecontext of this invention, polyclonal antibodies are typically mixturesof antibodies against a specific antigen or immunogen or epitope of aprotein which have been generated by immunization of a host organism,for example mammals, i.e. animals, including cattle, pigs, dogs, cats,donkeys, monkeys, including rodents, e.g. mice, hamsters, rabbits etc.,and man. Polyclonal antibodies conventionally recognize differentepitopes or regions of the same specific antigen, each of these epitopesin turn being capable of generating a clone of B lymphocytes whichproduces an antibody against this epitope. From such polyclonalantibodies or from the antibody sera obtained from the host organism,the individual antibodies specific against the particular epitopes canbe obtained by individualization to monoclonal antibodies. The presentinvention accordingly also provides RNA which codes for a monoclonalantibody, or a fragment or variant thereof, obtained byindividualization of polyclonal antibodies.

Monoclonal antibodies in the context of this invention are thereforetypically antibodies which are specific for a particular antigen orepitope (of a protein), i.e. bind this antigen or epitope (of a protein)with a high affinity, and conventionally are expressed by a hybridomacell. For the preparation of such monoclonal antibodies, thecorresponding antigen or immunogen or epitope of a protein is typicallyinjected at least once, but typically several times, into a hostorganism as described here, as a result of which the immune system ofthe host organism, in the presence of suitable adjuvants, is preferablystimulated to antibody production via activation of correspondinglyspecific B cells. The B lymphocytes are then conventionally selectivelypurified from the spleen or other organs or fluids suitable for thisfrom an animal immunized in this manner, and are fused with an immortalmyeloma cell to give the so-called hybridoma cell. After selectionmethods and cloning of the hybridomas or hybridoma cells formed, thoseclones which secernate, i.e. express and secrete, antibodies of thedesired specificity can be determined. These clones can be isolated andsequenced with known molecular biology methods. The data obtained fromsuch a sequencing can serve further in a nucleic acid synthesis forgeneration of synthetic DNA sequences or for screening a cDNA libraryand isolation of the cDNA fragments and generation of a DNA or nucleicacid template for in vitro or in vivo synthesis of the RNA according tothe invention which codes for an antibody. Where appropriate, the RNAcontained in the hybridomas can also be isolated, for example byfractionation, and subsequently the RNA molecules according to theinvention which code for the hybridoman antibody can be purified bymethods known to the person skilled in the art.

Nevertheless, RNA molecules which code for non-human monoclonal orpolyclonal antibody or fragments or variants thereof, e.g. murinemonoclonal antibodies or monoclonal antibodies from other, as describedhere, non-human host organisms or hybridoma cells are of only limitedsuitability for therapeutic use in humans, since in the human organismitself they conventionally cause an immune reaction with formation ofhuman anti-antibodies directed against these non-human host antibodies.As a result, such non-human monoclonal or polyclonal antibodies as arule can be administered to a person only a single time. To by-pass thisproblem, RNA molecules which code for chimeric, humanized and humanantibodies can also be provided according to the invention.

Chimeric antibodies in the context of the present invention arepreferably antibodies in which the constant domains of an antibody asdescribed here have been replaced by human sequences. Preferably,chimeric antibodies are formed from monoclonal or polyclonal antibodiesas described here.

Humanized antibodies in the context of the present invention areantibodies in which the constant and variable regions described above ofthe non-human monoclonal or polyclonal antibodies, with the exception ofthe hypervariable regions, have been replaced by human sequences.

RNA molecules which code for human antibodies, i.e. antibodies whichhave human sequences, that is to say in the constant regions (ifpresent) and in the variable regions, including the hypervariableregions, or fragments or variants thereof can furthermore be used in thecontext of the present invention. Such RNA molecules which code forhuman antibodies can be isolated from human tissue or originate fromimmunized host organisms as described here, e.g. mice, which are thentransgenic for the human IgG gene locus.

Preferably, the at least one coding sequence of the RNA according to theinvention encodes an antibody, preferably as defined herein, or afragment or variant thereof, wherein the antibody is preferably selectedfrom the group consisting of AAB-003; Abagovomab; Abciximab; Abituzumab;Abrilumab; Actoxumab; Adalimumab; Aducanumab; Afasevikumab; Aflibercept;Afutuzuab; Afutuzumab; Alacizumab_pegol; Alemtuzumab; Alirocumab;ALX-0061; Amatuximab; Anetumab_ravtansine; Anifrolumab; Anrukinzumab;Apolizumab; Apomab; Aquaporumab; Arcitumomab_99tc; Ascrinvacumab;Aselizuab; Atezolizumab; Atinumab; Atlizuab; Aurograb; Avelumab;Bapineuzumab; Basiliximab; Bavituximab; Begelomab; Benralizumab;Betalutin; Bevacituzuab; Bevacizumab_154-aspartic_acid;Bevacizumab_154-substitution; Bevacizumab_180-serine;Bevacizumab_180-substitution; Bevacizumab_beta; Bevacizumab;Bevacizumab-rhuMAb-VEGF; Bezlotoxumab; Bimagrumab; Bimekizumab;Bleselumab; Blinatumomab; Blinatumumab; Blontuvetmab; Blosozumab;Bococizumab; Brentuximab_vedotin; Briakinumab; Brodalumab; Brolucizumab;Brontictuzumab; BTT-1023; Burosumab; Canakinumab; Cantuzumab;Cantuzumab_mertansine; Cantuzumab_ravtansine; Caplacizumab; Carlumab;Cergutuzumab_amunaleukin; Certolizumab_pegol; Cetuximab;Citatuzumab_bogatox; Cixutumumab; Clazakizumab; Clivatuzumab_tetraxetan;Codrituzumab; Coltuximab_ravtansine; Conatumumab_CV; Conatumumab;Concizumab; Crenezumab; Crotedumab; Dacetuzumab; Dacliximab; Daclizumab;Dalotuzumab; Dapirolizumab_pegol; Daratumumab; Dectrekumab; Demcizumab;Denintuzumab_mafodotin; Denosumab; Depatuxizumab;Depatuxizumab_mafodotin; Dinutuximab_beta; Dinutuximab; Diridavumab;Domagrozumab; Drozituab; Drozitumab; Duligotumab; Duligotuzumab;Dupilumab; Durvalumab; Dusigitumab; Ecromeximab; Eculizumab; Efalizumab;Efungumab; Eldelumab; Elgemtumab; Elotuzumab; Emactuzumab; Emibetuzumab;Emicizumab; Enavatuzumab; Enfortumab; Enfortumabvedotin; Enoblituzumab;Enokizumab; Enoticumab; Ensituximab; Entolimod; Epratuzumab;Eptacog_beta; Erlizuab; Etaracizumab; Etrolizuab; Etrolizumab;Evinacumab; Evolocumab; Exbivirumab; Farletuzumab; Fasinumab;Fezakinumab; FG-3019; Fibatuzumab; Ficlatuzumab; Figitumumab; Firivumab;Flanvotumab; Fletikumab; Fontolizumab; Foralumab; Foravirumab;Fresolimumab; Fulranumab; Futuximab; Galcanezumab; Galiximab; Ganitumab;Gantenerumab; Gemtuzumab; Gemtuzumab_ozogamicin; Gevokizumab;Girentuximab; Glembatumumab; Goilixiab; Guselkumab; HuMab-001;HuMab-005; HuMab-006; HuMab-019; HuMab-021; HuMab-025; HuMab-027;HuMab-032; HuMab-033; HuMab-035; HuMab-036; HuMab-041; HuMab-044;HuMab-049; HuMab-050; HuMab-054; HuMab-055; HuMab-059; HuMab-060;HuMab-067; HuMab-072; HuMab-084; HuMab-091; HuMab-093; HuMab-098;HuMab-100; HuMab-106; HuMab_10F8; HuMab-111; HuMab-123; HuMab-124;HuMab-125; HuMab-127; HuMab-129; HuMab-132; HuMab-143; HuMab-150;HuMab-152; HuMab-153; HuMab-159; HuMab-160; HuMab-162; HuMab-163;HuMab-166; HuMab-167; HuMab-169; HuMab-7D8; huMAb-anti-MSP10.1;huMAb-anti-MSP10.2; HUMAB-Clone_18; HUMAB-Clone_22; HuMab-L612;HuMab_LC5002-002; HuMab_LC5002-003; HuMab_LC5002-005; HuMab_LC5002-007;HuMab_LC5002-018; Ibalizumab; Ibritumomab_tiuxetan; Icrucumab;Idarucizumab; Igatuzuab; IGF-IR_HUMAB-1A; IGF-IR_HUMAB-23;IGF-IR_HUMAB-8; ImAb1; Imalumab; Imgatuzumab; Inclacumab;Indatuximab_ravtansine; Indusatumab_vedotin; Inebilizumab;Insulin_peglispro; Interferon_beta-1b; Intetumumab;Iodine_(124I)_Girentuximab; lodine_(131I)_Derlotuxiab_biotin;lodine_(131I)_Derlotuximab_biotin; Ipilimumab; Iratumumab; Isatuximab;Itolizumab; Ixekizumab; Labetuzumab_govitecan; Lambrolizumab;Lampalizumab; Lanadelumab; Landogrozumab; Laprituximab_emtansine;Lealesoab; Lebrikizumab; Lenercept_chain1; Lenzilumab; Lerdelimumab;Lexatumumab; Libivirumab; Lifastuzumab; Lifastuzumab_vedotin;Ligelizumab; Lilotomab; Lintuzumab; Lirilumab; Lodelcizumab; Lokivetmab;Lorvotuzumab_mertansine; Lpathomab; Lucatumumab; Lulizumab_pegol;Lumiliximab; Lumretuzumab; Lutetium_(177Lu)_Iilotomab_satetraxetan;Margetuximab; Marzeptacog_alfa; Matuzumab; Mavrilimumab; MDX-1303;Mepolizumab; Metelimumab; Milatuzumab; Mirvetuximab; Modotuximab;Mogamulizumab; Monalizumab; Motavizumab; Moxetumomab_pasudotox;Muromonab-CD3; Namilumab; Naptumomab_estafenatox; Narnatumab;Natalizumab; Navicixizumab; Navivumab; Ndimab-varB; Necitumumab;Neliximab; Nemolizumab; Nesvacumab; Neuradiab; Nimotuzumab; Nivolumab;Obiltoxaximab; Obinutuzumab; Ocaratuzumab; Ocrelizumab; Ofatumumab;Olaratumab; Olizuab; Olokizumab; Omalizumab; Onartuzumab; Ontuxizumab;Opicinumab; Oportuzumab_monatox; Oreptacog_alfa; Orticumab;Otelixizumab; Otlertuzumab; Oxelumab; Ozanezumab; Ozoralizumab;Palivizumab; Pamrevlumab; Panitumumab; Pankoab; PankoMab; Panobacumab;Parsatuzumab; Pascolizumab; Pasotuxizumab; Pateclizumab; Patritumab;Pembrolizumab; Perakizumab; Pertuzuab; Pertuzumab;Pexelizumab_h5g1.1-scFv; Pexelizumab; PF-05082566; PF-05082568;Pidilizumab; Pinatuzumab_vedotin; Placulumab; Plozalizumab; Pogalizumab;Polatuzumab_vedotin; Ponezumab; Pritoxaximab; Pritumumab; Quilizumab;Racotumomab; Radretumab; Rafivirumab; Ralpancizumab; Ramucirumab;Ranibizivab; Ranibizumab; Refanezumab; REGN2810; rhuMab_HER2(9CI);rhuMab_HER2; rhuMAb-VEGF; Rilotumumab; Rinucumab; Risankizumab;Rituximab; Rivabazumab_pegol; Robatumumab; Roledumab; Romosozumab;Rontalizuab; Rontalizumab; Rovalpituzumab_tesirine; Rovelizumab;Ruplizumab; Sacituzumab_govitecan; Samalizumab; Sarilumab;Satumomab_pendetide; Secukinumab; Seribantumab; Setoxaximab;Sifalimumab; Siltuximab; Simtuzumab; Sirukumab; Sofituzumab_vedotin;Solanezumab; Solitomab; Sonepcizumab; Stamulumab; Suptavumab; Suvizumab;Tabalumab; Tacatuzuab; Tadocizumab; Talizumab; Tamtuvetmab; Tanezumab;Tarextumab; Tefibazumab; Tenatumomab; Teneliximab; Teplizumab;Teprotumumab; Tesidolumab; Tezepelumab; ThioMAb-chMA79b-HC(A118C);ThioMab-hu10A8.v1-HC(A118C); ThioMab-hu10A8.v1-HC(V205C);ThioMab-hu10A8.v1-LC(A118C); ThioMab-hu10A8.v1-LC(V205C);ThioMAb-huMA79b.v17-HC(A118C); ThioMAb-huMA79b.v18-HC(A118C);ThioMAb-huMA79b.v28-HC(A118C); ThioMAb-huMA79b.v28-LC(V205C); Ticilivab;Tigatuzumab; Tildrakizumab; Tisotumab_vedotin; Tocilizumab; Tosatoxumab;Tositumomab; Tovetumab; Tralokinumab; Trastuzuab; Trastuzumab_emtansine;Trastuzumab; TRC-105; Tregalizumab; Tremelimumab; Trevogrumab;Tucotuzumab_celmoleukin; Ublituximab; Ulocuplumab; Urelumab;Urtoxazumab; Ustekinumab; Vadastuximab_talirine; Vandortuzumab_vedotin;Vantictumab; Vanucizumab; Varlilumab; Vatelizumab; Vedolizumab;Veltuzumab; Vesencumab; Visilizumab; Volociximab; Vorsetuzumab;Vorsetuzumab_mafodotin; Yttrium_(90Y)_clivatuzumab_tetraxetan;Yttrium_Y_90_epratuzumab_tetraxetan; Yttrium_Y_90_epratuzumab;Zalutumumab; Zanolimumab; Zatuximab; Andecaliximab; Aprutumab;Azintuxizumab; Brazikumab; Cabiralizumab; Camrelizumab; Cosfroviximab;Crizanlizumab; Dezamizumab; Duvortuxizumab; Elezanumab; Emapalumab;Eptinezumab; Erenumab; Fremanezumab; Frunevetmab; Gatipotuzumab;Gedivumab; Gemetuzumab; Gilvetmab; Ifabotuzumab; Lacnotuzumab;Larcaviximab; Lendalizumab; Lesofavumab; Letolizumab; Losatuxizumab;Lupartumab; Lutikizumab; Oleclumab; Porgaviximab; Prezalumab;Ranevetmab; Remtolumab; Rosmantuzumab; Rozanolixizumab; Sapelizumab;Selicrelumab; Suvratoxumab; Tavolixizumab; Telisotuzumab;Telisotuzumab_vedotin; Timigutuzumab; Timolumab; Tomuzotuximab;Trastuzumab_duocarmazine; Varisacumab; Vunakizumab; Xentuzumab;anti-rabies_SO57; anti-rabies_SOJB; anti-rabies_SOJA; anti-rabies;anti-RSV_5ITB; anti-alpha-toxin_4U6V; anti-IsdB_5D1Q; anti-IsdB_5D1X;anti-IsdB_5D1Z; anti-HIV_b12; anti-HIV_2G12; anti-HIV_4E10;anti-HIV_VRC01; anti-HIV_PG9; anti-HIV_VRC07; anti-HIV_3BNC117;anti-HIV_10-1074; anti-HIV_PGT121; anti-HIV_PGDM1400; anti-HIV_N6;anti-HIV_10E8; anti-HIV_12A12; anti-HIV_12A21; anti-HIV_35022;anti-HIV_3BC176; anti-HIV_3BNC55; anti-HIV_3BNC60; anti-HIV_447-52D;anti-HIV_5H/I1-BMV-D5; anti-HIV_8ANC195; anti-HIV_CAP256-VRC26.01;anti-HIV_CAP256-VRC26.02; anti-HIV_CAP256-VRC26.03;anti-HIV_CAP256-VRC26.04; anti-HIV_CAP256-VRC26.05;anti-HIV_CAP256-VRC26.06; anti-HIV_CAP256-VRC26.07;anti-HIV_CAP256-VRC26.08; anti-HIV_CAP256-VRC26.09;anti-HIV_CAP256-VRC26.10; anti-HIV_CAP256-VRC26.11;anti-HIV_CAP256-VRC26.12; anti-HIV_CAP256-VRC26.I1;anti-HIV_CAP256-VRC26.I2; anti-HIV_CAP256-VRC26.UCA; anti-HIV_CH01;anti-HIVCH02; anti-HIV_CH03; anti-HIV_CH04; anti-HIV_CH103;anti-HIV_M66.6; anti-HIV_NIH45-46; anti-HIV_PG16; anti-HIV_PGT122;anti-HIV_PGT123; anti-HIV_PGT125; anti-HIV_PGT126; anti-HIV_PGT127;anti-HIV_PGT128; anti-HIV_PGT130; anti-HIV_PGT131; anti-HIV_PGT135;anti-HIV_PGT136; anti-HIV_PGT137; anti-HIV_PGT141; anti-HIV_PGT142;anti-HIV_PGT143; anti-HIV_PGT144; anti-HIV_PGT145; anti-HIV_PGT151;anti-HIV_PGT152; anti-HIV_VRC-CH30; anti-HIV_VRC-CH31;anti-HIV_VRC-CH32; anti-HIV_VRC-CH33; anti-HIV_VRC-CH34;anti-HIV_VRC-PG04; anti-HIV_VRC-PG04b; anti-HIV_VRC-PG20;anti-HIV_VRC02; anti-HIV_VRC03; anti-HIV_VRC23; anti-HIV_SCCK;anti-HIV_SAWN; anti-HIV_3QEG; anti-HIV_1N0X; anti-HIV_3QEH;anti-HIV_2B1H; anti-HIV_3TNM; anti-HIV_3UJJ; anti-HIV_3UJI;anti-HIV_2QSC; anti-HIV_3MLZ; anti-HIV_3MLX; anti-HIV_3MLW;anti-HIV_3MLV; anti-HIV_3MLU; anti-HIV_3MLT; anti-HIV_3GO1;anti-HIV_4XCY; anti-HIV_4YBL; anti-HIV_4R4N; anti-HIV_4R4B;anti-HIV_3JUY; anti-HIV_4KG5; anti-HIV-1; anti-HIV_V3; anti-HIV_CD4bs;anti-HIV_V2; anti-HIV_C38-VRC18.02; anti-HIV_44-VRC13.02; anti-HIV_45;anti-HIV_cap256-206-252885; anti-HIV_cap256-206-249183;anti-HIV_cap256-206-220956; anti-HIV_cap256-206-220629;anti-HIV_cap256-206-200599; anti-HIV_cap256-206-186347;anti-HIV_cap256-206-186226; anti-HIV_cap256-206-179686;anti-HIV_cap256-206-173707; anti-HIV_cap256-206-173339;anti-HIV_cap256-206-172689; anti-HIV_cap256-206-162744;anti-HIV_cap256-206-146057; anti-HIV_cap256-206-139519;anti-HIV_cap256-206-136316; anti-HIV_cap256-206-116098;anti-HIV_cap256-206-115862; anti-HIV_cap256-206-107018;anti-HIV_cap256-206-098644; anti-HIV_cap256-206-098135;anti-HIV_cap256-206-096276; anti-HIV_cap256-206-092794;anti-HIV_cap256-206-086817; anti-HIV_cap256-206-086446;anti-HIV_cap256-206-086180; anti-HIV_cap256-206-083708;anti-HIV_cap256-206-079556; anti-HIV_cap256-206-078657;anti-HIV_cap256-206-075802; anti-HIV_cap256-206-069097;anti-HIV_cap256-206-067758; anti-HIV_cap256-206-057019;anti-HIV_cap256-206-055385; anti-HIV_cap256-206-053187;anti-HIV_cap256-206-053139; anti-HIV_cap256-206-050350;anti-HIV_cap256-206-046207; anti-HIV_cap256-206-043389;anti-HIV_cap256-206-042555; anti-HIV_cap256-206-029720;anti-HIV_cap256-206-028848; anti-HIV_cap256-206-027652;anti-HIV_cap256-206-024075; anti-HIV_cap256-206-008748;anti-HIV_cap256-206-008530; anti-HIV_cap256-176-723043;anti-HIV_cap256-176-600049; anti-HIV_cap256-176-531926;anti-HIV_cap256-176-504134; anti-HIV_cap256-119-186229;anti-HIV_cap256-119-183891; anti-HIV_cap256-119-183631;anti-HIV_cap256-119-182676; anti-HIV_cap256-119-180772;anti-HIV_cap256-119-180508; anti-HIV_cap256-119-180260;anti-HIV_cap256-119-180173; anti-HIV_cap256-119-179839;anti-HIV_cap256-119-179262; anti-HIV_cap256-119-178995;anti-HIV_cap256-119-178455; anti-HIV_cap256-119-177993;anti-HIV_cap256-119-177727; anti-HIV_cap256-119-176746;anti-HIV_cap256-119-176241; anti-HIV_cap256-119-175215;anti-HIV_cap256-119-173928; anti-HIV_cap256-119-173495;anti-HIV_cap256-119-172882; anti-HIV_cap256-119-172429;anti-HIV_cap256-119-172223; anti-HIV_cap256-119-171838;anti-HIV_cap256-119-171587; anti-HIV_cap256-119-169596;anti-HIV_cap256-119-169523; anti-HIV_cap256-119-169462;anti-HIV_cap256-119-169092; anti-HIV_cap256-119-168680;anti-HIV_cap256-119-166385; anti-HIV_cap256-119-165943;anti-HIV_cap256-119-165738; anti-HIV_cap256-119-164913;anti-HIV_cap256-119-164167; anti-HIV_cap256-119-163558;anti-HIV_cap256-119-162043; anti-HIV_cap256-119-161718;anti-HIV_cap256-119-161675; anti-HIV_cap256-119-161053;anti-HIV_cap256-119-159499; anti-HIV_cap256-119-159114;anti-HIV_cap256-119-156751; anti-HIV_cap256-119-155656;anti-HIV_cap256-119-154420; anti-HIV_cap256-119-153954;anti-HIV_cap256-119-153864; anti-HIV_cap256-119-153793;anti-HIV_cap256-119-153462; anti-HIV_cap256-119-153124;anti-HIV_cap256-119-153025; anti-HIV_cap256-119-152713;anti-HIV_cap256-119-151794; anti-HIV_cap256-119-150980;anti-HIV_cap256-119-148895; anti-HIV_cap256-119-148848;anti-HIV_cap256-119-148743; anti-HIV_cap256-119-148595;anti-HIV_cap256-119-148490; anti-HIV_cap256-119-148470;anti-HIV_cap256-119-148107; anti-HIV_cap256-119-147933;anti-HIV_cap256-119-147434; anti-HIV_cap256-119-146106;anti-HIV_cap256-119-145604; anti-HIV_cap256-119-143998;anti-HIV_cap256-119-143441; anti-HIV_cap256-119-141307;anti-HIV_cap256-119-140896; anti-HIV_cap256-119-140090;anti-HIV_cap256-119-140037; anti-HIV_cap256-119-139135;anti-HIV_cap256-119-137881; anti-HIV_cap256-119-137643;anti-HIV_cap256-119-137170; anti-HIV_cap256-119-136616;anti-HIV_cap256-119-136206; anti-HIV_cap256-119-135565;anti-HIV_cap256-119-135025; anti-HIV_cap256-119-133983;anti-HIV_cap256-119-133917; anti-HIV_cap256-119-132663;anti-HIV_cap256-119-132113; anti-HIV_cap256-119-131839;anti-HIV_cap256-119-130626; anti-HIV_cap256-119-130191;anti-HIV_cap256-119-129798; anti-HIV_cap256-119-128745;anti-HIV_cap256-119-128593; anti-HIV_cap256-119-128152;anti-HIV_cap256-119-127693; anti-HIV_cap256-119-126684;anti-HIV_cap256-119-126056; anti-HIV_cap256-119-125765;anti-HIV_cap256-119-125106; anti-HIV_cap256-119-124026;anti-HIV_cap256-119-121783; anti-HIV_cap256-119-121208;anti-HIV_cap256-119-120945; anti-HIV_cap256-119-118229;anti-HIV_cap256-119-118025; anti-HIV_cap256-119-117418;anti-HIV_cap256-119-117250; anti-HIV_cap256-119-117230;anti-HIV_cap256-119-116999; anti-HIV_cap256-119-116558;anti-HIV_cap256-119-116484; anti-HIV_cap256-119-114844;anti-HIV_cap256-119-114141; anti-HIV_cap256-119-111917;anti-HIV_cap256-119-111862; anti-HIV_cap256-119-110064;anti-HIV_cap256-119-109192; anti-HIV_cap256-119-108793;anti-HIV_cap256-119-108127; anti-HIV_cap256-119-107758;anti-HIV_cap256-119-107209; anti-HIV_cap256-119-107184;anti-HIV_cap256-119-106827; anti-HIV_cap256-119-106511;anti-HIV_cap256-119-106327; anti-HIV_cap256-119-105486;anti-HIV_cap256-119-105197; anti-HIV_cap256-119-104946;anti-HIV_cap256-119-103667; anti-HIV_cap256-119-103385;anti-HIV_cap256-119-103267; anti-HIV_cap256-119-103011;anti-HIV_cap256-119-102072; anti-HIV_cap256-119-101945;anti-HIV_cap256-119-101319; anti-HIV_cap256-119-100871;anti-HIV_cap256-119-100838; anti-HIV_cap256-119-100025;anti-HIV_cap256-119-100000; anti-HIV_cap256-119-098890;anti-HIV_cap256-119-098715; anti-HIV_cap256-119-098632;anti-HIV_cap256-119-097199; anti-HIV_cap256-119-096189;anti-HIV_cap256-119-094581; anti-HIV_cap256-119-094200;anti-HIV_cap256-119-094158; anti-HIV_cap256-119-092814;anti-HIV_cap256-119-092808; anti-HIV_cap256-119-092573;anti-HIV_cap256-119-090815; anti-HIV_cap256-119-090368;anti-HIV_cap256-119-089710; anti-HIV_cap256-119-088555;anti-HIV_cap256-119-087962; anti-HIV_cap256-119-086903;anti-HIV_cap256-119-086804; anti-HIV_cap256-119-085910;anti-HIV_cap256-119-085772; anti-HIV_cap256-119-084603;anti-HIV_cap256-119-084276; anti-HIV_cap256-119-082288;anti-HIV_cap256-119-080383; anti-HIV_cap256-119-079333;anti-HIV_cap256-119-078618; anti-HIV_cap256-119-077466;anti-HIV_cap256-119-076284; anti-HIV_cap256-119-074680;anti-HIV_cap256-119-074081; anti-HIV_cap256-119-071704;anti-HIV_cap256-119-071266; anti-HIV_cap256-119-069667;anti-HIV_cap256-119-069591; anti-HIV_cap256-119-068691;anti-HIV_cap256-119-068488; anti-HIV_cap256-119-067536;anti-HIV_cap256-119-065852; anti-HIV_cap256-119-065457;anti-HIV_cap256-119-064501; anti-HIV_cap256-119-063568;anti-HIV_cap256-119-063103; anti-HIV_cap256-119-061027;anti-HIV_cap256-119-058232; anti-HIV_cap256-119-057341;anti-HIV_cap256-119-056895; anti-HIV_cap256-119-056402;anti-HIV_cap256-119-056034; anti-HIV_cap256-119-055042;anti-HIV_cap256-119-054776; anti-HIV_cap256-119-054539;anti-HIV_cap256-119-054112; anti-HIV_cap256-119-053339;anti-HIV_cap256-119-052404; anti-HIV_cap256-119-051123;anti-HIV_cap256-119-051077; anti-HIV_cap256-119-050442;anti-HIV_cap256-119-049433; anti-HIV_cap256-119-047532;anti-HIV_cap256-119-047489; anti-HIV_cap256-119-046020;anti-HIV_cap256-119-044746; anti-HIV_cap256-119-044740;anti-HIV_cap256-119-043790; anti-HIV_cap256-119-042880;anti-HIV_cap256-119-042606; anti-HIV_cap256-119-042444;anti-HIV_cap256-119-040328; anti-HIV_cap256-119-040164;anti-HIV_cap256-119-039130; anti-HIV_cap256-119-038138;anti-HIV_cap256-119-037868; anti-HIV_cap256-119-037102;anti-HIV_cap256-119-036683; anti-HIV_cap256-119-036495;anti-HIV_cap256-119-035375; anti-HIV_cap256-119-035165;anti-HIV_cap256-119-035109; anti-HIV_cap256-119-033789;anti-HIV_cap256-119-033641; anti-HIV_cap256-119-032113;anti-HIV_cap256-119-031739; anti-HIV_cap256-119-030932;anti-HIV_cap256-119-030740; anti-HIV_cap256-119-030197;anti-HIV_cap256-119-027047; anti-HIV_cap256-119-026950;anti-HIV_cap256-119-026279; anti-HIV_cap256-119-025355;anti-HIV_cap256-119-025301; anti-HIV_cap256-119-025010;anti-HIV_cap256-119-024631; anti-HIV_cap256-119-024467;anti-HIV_cap256-119-023805; anti-HIV_cap256-119-021736;anti-HIV_cap256-119-021203; anti-HIV_cap256-119-020569;anti-HIV_cap256-119-019432; anti-HIV_cap256-119-018827;anti-HIV_cap256-119-018483; anti-HIV_cap256-119-018118;anti-HIV_cap256-119-017782; anti-HIV_cap256-119-017669;anti-HIV_cap256-119-016976; anti-HIV_cap256-119-015432;anti-HIV_cap256-119-015281; anti-HIV_cap256-119-014957;anti-HIV_cap256-119-014777; anti-HIV_cap256-119-014313;anti-HIV_cap256-119-014219; anti-HIV_cap256-119-013631;anti-HIV_cap256-119-012924; anti-HIV_cap256-119-011793;anti-HIV_cap256-119-011413; anti-HIV_cap256-119-011323;anti-HIV_cap256-119-011233; anti-HIV_cap256-119-009038;anti-HIV_cap256-119-008756; anti-HIV_cap256-119-008055;anti-HIV_cap256-119-006949; anti-HIV_cap256-119-006685;anti-HIV_cap256-119-006015; anti-HIV_cap256-119-005841;anti-HIV_cap256-119-005824; anti-HIV_cap256-119-005494;anti-HIV_cap256-119-004949; anti-HIV_cap256-119-004422;anti-HIV_cap256-119-003932; anti-HIV_cap256-119-003577;anti-HIV_cap256-119-002155; anti-HIV_cap256-119-002017;anti-HIV_cap256-119-001312; anti-HIV_cap256-119-001017;anti-HIV_cap256-119-000594; anti-HIV_cap256-059-241099;anti-HIV_cap256-059-207529; anti-HIV_cap256-059-205541;anti-HIV_cap256-059-188439; anti-HIV_cap256-059-187234;anti-HIV_cap256-059-187047; anti-HIV_cap256-059-186068;anti-HIV_cap256-059-182835; anti-HIV_cap256-059-176659;anti-HIV_cap256-059-172956; anti-HIV_cap256-059-171272;anti-HIV_cap256-059-168734; anti-HIV_cap256-059-155838;anti-HIV_cap256-059-149799; anti-HIV_cap256-059-148168;anti-HIV_cap256-059-144685; anti-HIV_cap256-059-140017;anti-HIV_cap256-059-137547; anti-HIV_cap256-059-131908;anti-HIV_cap256-059-116006; anti-HIV_cap256-059-115783;anti-HIV_cap256-059-114609; anti-HIV_cap256-059-113952;anti-HIV_cap256-059-113878; anti-HIV_cap256-059-113622;anti-HIV_cap256-059-109427; anti-HIV_cap256-059-109081;anti-HIV_cap256-059-107590; anti-HIV_cap256-059-107504;anti-HIV_cap256-059-099614; anti-HIV_cap256-059-098972;anti-HIV_cap256-059-097236; anti-HIV_cap256-059-091487;anti-HIV_cap256-059-089812; anti-HIV_cap256-059-088468;anti-HIV_cap256-059-088341; anti-HIV_cap256-059-086533;anti-HIV_cap256-059-086043; anti-HIV_cap256-059-084191;anti-HIV_cap256-059-082135; anti-HIV_cap256-059-079417;anti-HIV_cap256-059-076027; anti-HIV_cap256-059-075082;anti-HIV_cap256-059-072575; anti-HIV_cap256-059-071926;anti-HIV_cap256-059-069638; anti-HIV_cap256-059-069165;anti-HIV_cap256-059-068956; anti-HIV_cap256-059-068876;anti-HIV_cap256-059-067733; anti-HIV_cap256-059-067450;anti-HIV_cap256-059-065694; anti-HIV_cap256-059-065109;anti-HIV_cap256-059-065060; anti-HIV_cap256-059-064001;anti-HIV_cap256-059-063270; anti-HIV_cap256-059-061357;anti-HIV_cap256-059-059834; anti-HIV_cap256-059-059313;anti-HIV_cap256-059-057130; anti-HIV_cap256-059-050520;anti-HIV_cap256-059-049839; anti-HIV_cap256-059-048503;anti-HIV_cap256-059-045516; anti-HIV_cap256-059-044188;anti-HIV_cap256-059-044105; anti-HIV_cap256-059-042100;anti-HIV_cap256-059-040742; anti-HIV_cap256-059-040554;anti-HIV_cap256-059-039660; anti-HIV_cap256-059-039298;anti-HIV_cap256-059-037873; anti-HIV_cap256-059-037633;anti-HIV_cap256-059-036817; anti-HIV_cap256-059-032787;anti-HIV_cap256-059-032427; anti-HIV_cap256-059-029390;anti-HIV_cap256-059-027877; anti-HIV_cap256-059-026640;anti-HIV_cap256-059-026017; anti-HIV_cap256-059-024100;anti-HIV_cap256-059-023966; anti-HIV_cap256-059-020534;anti-HIV_cap256-059-019513; anti-HIV_cap256-059-012963;anti-HIV_cap256-059-010396; anti-HIV_cap256-059-008136;anti-HIV_cap256-059-006147; anti-HIV_cap256-059-005081;anti-HIV_cap256-059-005006; anti-HIV_cap256-059-004451;anti-HIV_cap256-059-003571; anti-HIV_cap256-059-003449;anti-HIV_cap256-059-002712; anti-HIV_cap256-059-001573;anti-HIV_cap256-059-001379; anti-HIV_cap256-059-001029;anti-HIV_cap256-048-165087; anti-HIV_cap256-048-158861;anti-HIV_cap256-048-158280; anti-HIV_cap256-048-157928;anti-HIV_cap256-048-157056; anti-HIV_cap256-048-156422;anti-HIV_cap256-048-152863; anti-HIV_cap256-048-152770;anti-HIV_cap256-048-150027; anti-HIV_cap256-048-148246;anti-HIV_cap256-048-147428; anti-HIV_cap256-048-146603;anti-HIV_cap256-048-145735; anti-HIV_cap256-048-145116;anti-HIV_cap256-048-144077; anti-HIV_cap256-048-142876;anti-HIV_cap256-048-140582; anti-HIV_cap256-048-139355;anti-HIV_cap256-048-139151; anti-HIV_cap256-048-137672;anti-HIV_cap256-048-137506; anti-HIV_cap256-048-137270;anti-HIV_cap256-048-135447; anti-HIV_cap256-048-131966;anti-HIV_cap256-048-131008; anti-HIV_cap256-048-129369;anti-HIV_cap256-048-128476; anti-HIV_cap256-048-128270;anti-HIV_cap256-048-126220; anti-HIV_cap256-048-125713;anti-HIV_cap256-048-123934; anti-HIV_cap256-048-122673;anti-HIV_cap256-048-122208; anti-HIV_cap256-048-121552;anti-HIV_cap256-048-120643; anti-HIV_cap256-048-118458;anti-HIV_cap256-048-118112; anti-HIV_cap256-048-116469;anti-HIV_cap256-048-113917; anti-HIV_cap256-048-112368;anti-HIV_cap256-048-112047; anti-HIV_cap256-048-112029;anti-HIV_cap256-048-110957; anti-HIV_cap256-048-110526;anti-HIV_cap256-048-109336; anti-HIV_cap256-048-108152;anti-HIV_cap256-048-107799; anti-HIV_cap256-048-107384;anti-HIV_cap256-048-106530; anti-HIV_cap256-048-106464;anti-HIV_cap256-048-106411; anti-HIV_cap256-048-106306;anti-HIV_cap256-048-104496; anti-HIV_cap256-048-103074;anti-HIV_cap256-048-100832; anti-HIV_cap256-048-100188;anti-HIV_cap256-048-099645; anti-HIV_cap256-048-098137;anti-HIV_cap256-048-097878; anti-HIV_cap256-048-097510;anti-HIV_cap256-048-097313; anti-HIV_cap256-048-096626;anti-HIV_cap256-048-096483; anti-HIV_cap256-048-095691;anti-HIV_cap256-048-095525; anti-HIV_cap256-048-094783;anti-HIV_cap256-048-094356; anti-HIV_cap256-048-090756;anti-HIV_cap256-048-089065; anti-HIV_cap256-048-084986;anti-HIV_cap256-048-083355; anti-HIV_cap256-048-082462;anti-HIV_cap256-048-082246; anti-HIV_cap256-048-080752;anti-HIV_cap256-048-078409; anti-HIV_cap256-048-078273;anti-HIV_cap256-048-078062; anti-HIV_cap256-048-077798;anti-HIV_cap256-048-073853; anti-HIV_cap256-048-071661;anti-HIV_cap256-048-071360; anti-HIV_cap256-048-070955;anti-HIV_cap256-048-070061; anti-HIV_cap256-048-069669;anti-HIV_cap256-048-069205; anti-HIV_cap256-048-068882;anti-HIV_cap256-048-067764; anti-HIV_cap256-048-066845;anti-HIV_cap256-048-065226; anti-HIV_cap256-048-063717;anti-HIV_cap256-048-063150; anti-HIV_cap256-048-062431;anti-HIV_cap256-048-060745; anti-HIV_cap256-048-060420;anti-HIV_cap256-048-060014; anti-HIV_cap256-048-059747;anti-HIV_cap256-048-058393; anti-HIV_cap256-048-058159;anti-HIV_cap256-048-057127; anti-HIV_cap256-048-056251;anti-HIV_cap256-048-055421; anti-HIV_cap256-048-054989;anti-HIV_cap256-048-054759; anti-HIV_cap256-048-052573;anti-HIV_cap256-048-051477; anti-HIV_cap256-048-051299;anti-HIV_cap256-048-050815; anti-HIV_cap256-048-049884;anti-HIV_cap256-048-049170; anti-HIV_cap256-048-048531;anti-HIV_cap256-048-048259; anti-HIV_cap256-048-047313;anti-HIV_cap256-048-046596; anti-HIV_cap256-048-044781;anti-HIV_cap256-048-042599; anti-HIV_cap256-048-041276;anti-HIV_cap256-048-040200; anti-HIV_cap256-048-039061;anti-HIV_cap256-048-038515; anti-HIV_cap256-048-038255;anti-HIV_cap256-048-038177; anti-HIV_cap256-048-035513;anti-HIV_cap256-048-034112; anti-HIV_cap256-048-033983;anti-HIV_cap256-048-032688; anti-HIV_cap256-048-031092;anti-HIV_cap256-048-030464; anti-HIV_cap256-048-030289;anti-HIV_cap256-048-030261; anti-HIV_cap256-048-029362;anti-HIV_cap256-048-027638; anti-HIV_cap256-048-027613;anti-HIV_cap256-048-026627; anti-HIV_cap256-048-026239;anti-HIV_cap256-048-025518; anti-HIV_cap256-048-024854;anti-HIV_cap256-048-024537; anti-HIV_cap256-048-021781;anti-HIV_cap256-048-021758; anti-HIV_cap256-048-020988;anti-HIV_cap256-048-020663; anti-HIV_cap256-048-020590;anti-HIV_cap256-048-019765; anti-HIV_cap256-048-019254;anti-HIV_cap256-048-018073; anti-HIV_cap256-048-016775;anti-HIV_cap256-048-016069; anti-HIV_cap256-048-015867;anti-HIV_cap256-048-015673; anti-HIV_cap256-048-015156;anti-HIV_cap256-048-014521; anti-HIV_cap256-048-014475;anti-HIV_cap256-048-013798; anti-HIV_cap256-048-013271;anti-HIV_cap256-048-013180; anti-HIV_cap256-048-012148;anti-HIV_cap256-048-011870; anti-HIV_cap256-048-011530;anti-HIV_cap256-048-010968; anti-HIV_cap256-048-010224;anti-HIV_cap256-048-009749; anti-HIV_cap256-048-009623;anti-HIV_cap256-048-008234; anti-HIV_cap256-048-008149;anti-HIV_cap256-048-007301; anti-HIV_cap256-048-007174;anti-HIV_cap256-048-007079; anti-HIV_cap256-048-007033;anti-HIV_cap256-048-006128; anti-HIV_cap256-048-005999;anti-HIV_cap256-048-005394; anti-HIV_cap256-048-004226;anti-HIV_cap256-048-004097; anti-HIV_cap256-048-003289;anti-HIV_cap256-048-002601; anti-HIV_cap256-048-002129;anti-HIV_cap256-048-001875; anti-HIV_cap256-048-001302;anti-HIV_cap256-048-001203; anti-HIV_cap256-048-000383;anti-HIV_cap256-038-261791; anti-HIV_cap256-038-241540;anti-HIV_cap256-038-235677; anti-HIV_cap256-038-234314;anti-HIV_cap256-038-234273; anti-HIV_cap256-038-223164;anti-HIV_cap256-038-220289; anti-HIV_cap256-038-220020;anti-HIV_cap256-038-216853; anti-HIV_cap256-038-213466;anti-HIV_cap256-038-213212; anti-HIV_cap256-038-213120;anti-HIV_cap256-038-212592; anti-HIV_cap256-038-211790;anti-HIV_cap256-038-209916; anti-HIV_cap256-038-207938;anti-HIV_cap256-038-202245; anti-HIV_cap256-038-197721;anti-HIV_cap256-038-196679; anti-HIV_cap256-038-196118;anti-HIV_cap256-038-195382; anti-HIV_cap256-038-180001;anti-HIV_cap256-038-178021; anti-HIV_cap256-038-177104;anti-HIV_cap256-038-171261; anti-HIV_cap256-038-169090;anti-HIV_cap256-038-168705; anti-HIV_cap256-038-167685;anti-HIV_cap256-038-158775; anti-HIV_cap256-038-157318;anti-HIV_cap256-038-153058; anti-HIV_cap256-038-150027;anti-HIV_cap256-038-146372; anti-HIV_cap256-038-141868;anti-HIV_cap256-038-141616; anti-HIV_cap256-038-127989;anti-HIV_cap256-038-118109; anti-HIV_cap256-038-112226;anti-HIV_cap256-038-105918; anti-HIV_cap256-038-104487;anti-HIV_cap256-038-102308; anti-HIV_cap256-038-091115;anti-HIV_cap256-038-090262; anti-HIV_cap256-038-083260;anti-HIV_cap256-038-080981; anti-HIV_cap256-038-080873;anti-HIV_cap256-038-074413; anti-HIV_cap256-038-073153;anti-HIV_cap256-038-064227; anti-HIV_cap256-038-061640;anti-HIV_cap256-038-059482; anti-HIV_cap256-038-054000;anti-HIV_cap256-038-050554; anti-HIV_cap256-038-044256;anti-HIV_cap256-038-040944; anti-HIV_cap256-038-040090;anti-HIV_cap256-038-032874; anti-HIV_cap256-038-025899;anti-HIV_cap256-038-024581; anti-HIV_cap256-038-013345;anti-HIV_cap256-038-011559; anti-HIV_cap256-038-009634;anti-HIV_cap256-038-006730; anti-HIV_cap256-038-004887;anti-HIV_cap256-038-004840; anti-HIV_cap256-038-002181;anti-HIV_cap256-038-001902; anti-HIV_cap256-038-000976;anti-HIV_cap256-038-000384; anti-HIV_206-314431; anti-HIV_206-247594;anti-HIV_206-116890; anti-HIV_206-072383; anti-HIV_206-037527;anti-HIV_206-009095; anti-HIV_176-503620; anti-HIV_176-478726;anti-HIV_276-245056; anti-HIV_176-164413; anti-HIV_176-094308;anti-HIV_176-065321; anti-HIV_119-099719; anti-HIV_119-099536;anti-HIV_119-098907; anti-HIV_119-098555; anti-HIV_119-097828;anti-HIV_119-096480; anti-HIV_119-095664; anti-HIV_119-095212;anti-HIV_119-094773; anti-HIV_119-094508; anti-HIV_119-093795;anti-HIV_119-093732; anti-HIV_119-092903; anti-HIV_119-092284;anti-HIV_119-091586; anti-HIV_119-091023; anti-HIV_119-090334;anti-HIV_119-088694; anti-HIV_119-088499; anti-HIV_119-088298;anti-HIV_119-087488; anti-HIV_119-087423; anti-HIV_119-087371;anti-HIV_119-087279; anti-HIV_119-087146; anti-HIV_119-087048;anti-HIV_119-085802; anti-HIV_119-085784; anti-HIV_119-085370;anti-HIV_119-085276; anti-HIV_119-084885; anti-HIV_119-084874;anti-HIV_119-084691; anti-HIV_119-083793; anti-HIV_119-083163;anti-HIV_119-082331; anti-HIV_119-082070; anti-HIV_119-081512;anti-HIV_119-080816; anti-HIV_119-079302; anti-HIV_119-079292;anti-HIV_119-079289; anti-HIV_119-078935; anti-HIV_119-078702;anti-HIV_119-078593; anti-HIV_119-077708; anti-HIV_119-076904;anti-HIV_119-075862; anti-HIV_119-075465; anti-HIV_119-074822;anti-HIV_119-074629; anti-HIV_119-074500; anti-HIV_119-073911;anti-HIV_119-072765; anti-HIV_119-072313; anti-HIV_119-072280;anti-HIV_119-071693; anti-HIV_119-071353; anti-HIV_119-069711;anti-HIV_119-069061; anti-HIV_119-068202; anti-HIV_119-068063;anti-HIV_119-067980; anti-HIV_119-067866; anti-HIV_119-067756;anti-HIV_119-066859; anti-HIV_119-065821; anti-HIV_119-065191;anti-HIV_119-064667; anti-HIV_119-063791; anti-HIV_119-062989;anti-HIV_119-062286; anti-HIV_119-061416; anti-HIV_119-061344;anti-HIV_119-060240; anti-HIV_119-060184; anti-HIV_119-058035;anti-HIV_119-057858; anti-HIV_119-057473; anti-HIV_119-057090;anti-HIV_119-055754; anti-HIV_119-054899; anti-HIV_119-054501;anti-HIV_119-051867; anti-HIV_119-051814; anti-HIV_119-051567;anti-HIV_119-051483; anti-HIV_119-050913; anti-HIV_119-050187;anti-HIV_119-049069; anti-HIV_119-048517; anti-HIV_119-048470;anti-HIV_119-048303; anti-HIV_119-048021; anti-HIV_119-047928;anti-HIV_119-047384; anti-HIV_119-047145; anti-HIV_119-046752;anti-HIV_119-046660; anti-HIV_119-046202; anti-HIV_119-045790;anti-HIV_119-044670; anti-HIV_119-044140; anti-HIV_119-042776;anti-HIV_119-042581; anti-HIV_119-040905; anti-HIV_119-040322;anti-HIV_119-039892; anti-HIV_119-039764; anti-HIV_119-039188;anti-HIV_119-039058; anti-HIV_119-038837; anti-HIV_119-038396;anti-HIV_119-036918; anti-HIV_119-036592; anti-HIV_119-036310;anti-HIV_119-035618; anti-HIV_119-035569; anti-HIV_119-035466;anti-HIV_119-035157; anti-HIV_119-035121; anti-HIV_119-035046;anti-HIV_119-034754; anti-HIV_119-034318; anti-HIV_119-033780;anti-HIV_119-033632; anti-HIV_119-033183; anti-HIV_119-030696;anti-HIV_119-030059; anti-HIV_119-029589; anti-HIV_119-029448;anti-HIV_119-029220; anti-HIV_119-028317; anti-HIV_119-028165;anti-HIV_119-027147; anti-HIV_119-026743; anti-HIV_119-026508;anti-HIV_119-025683; anti-HIV_119-025614; anti-HIV_119-025548;anti-HIV_119-025526; anti-HIV_119-023552; anti-HIV_119-023092;anti-HIV_119-022793; anti-HIV_119-022395; anti-HIV_119-022334;anti-HIV_119-021866; anti-HIV_119-021278; anti-HIV_119-021183;anti-HIV_119-019376; anti-HIV_119-019238; anti-HIV_119-018500;anti-HIV_119-018318; anti-HIV_119-018218; anti-HIV_119-017876;anti-HIV_119-017740; anti-HIV_119-017128; anti-HIV_119-017044;anti-HIV_119-016644; anti-HIV_119-015878; anti-HIV_119-015538;anti-HIV_119-015455; anti-HIV_119-014425; anti-HIV_119-013582;anti-HIV_119-013364; anti-HIV_119-012886; anti-HIV_119-012249;anti-HIV_119-012161; anti-HIV_119-012110; anti-HIV_119-012100;anti-HIV_119-011651; anti-HIV_119-011479; anti-HIV_119-011232;anti-HIV_119-011175; anti-HIV_119-008396; anti-HIV_119-007148;anti-HIV_119-007029; anti-HIV_119-004707; anti-HIV_119-003910;anti-HIV_119-002450; anti-HIV_119-001552; anti-HIV_059-188169;anti-HIV_059-183739; anti-HIV_059-182376; anti-HIV_059-182199;anti-HIV_059-169202; anti-HIV_059-155645; anti-HIV_059-151619;anti-HIV_059-146503; anti-HIV_059-136098; anti-HIV_059-105516;anti-HIV_059-095709; anti-HIV_059-069468; anti-HIV_059-060026;anti-HIV_059-053668; anti-HIV_059-052864; anti-HIV_059-050968;anti-HIV_059-046422; anti-HIV_059-045120; anti-HIV_059-039932;anti-HIV_059-038595; anti-HIV_059-035082; anti-HIV_059-029204;anti-HIV_059-025235; anti-HIV_059-015192; anti-HIV_059-007060;anti-HIV_059-006953; anti-HIV_059-005953; anti-HIV_059-003725;anti-HIV_059-002618; anti-HIV_059-001522; anti-HIV_059-000731;anti-HIV_059-000634; anti-HIV_048-250757; anti-HIV_048-250716;anti-HIV_048-250463; anti-HIV_048-248153; anti-HIV_048-247532;anti-HIV_048-245846; anti-HIV_048-244016; anti-HIV_048-243682;anti-HIV_048-243588; anti-HIV_048-241775; anti-HIV_048-237996;anti-HIV_048-237730; anti-HIV_048-237253; anti-HIV_048-234100;anti-HIV_048-230882; anti-HIV_048-229473; anti-HIV_048-228238;anti-HIV_048-228027; anti-HIV_048-227795; anti-HIV_048-227770;anti-HIV_048-225298; anti-HIV_048-225090; anti-HIV_048-224187;anti-HIV_048-223055; anti-HIV_048-222711; anti-HIV_048-221209;anti-HIV_048-220629; anti-HIV_048-219430; anti-HIV_048-216250;anti-HIV_048-216133; anti-HIV_048-214886; anti-HIV_048-214709;anti-HIV_048-214001; anti-HIV_048-213230; anti-HIV_048-212574;anti-HIV_048-212207; anti-HIV_048-209146; anti-HIV_048-208206;anti-HIV_048-208194; anti-HIV_048-207744; anti-HIV_048-206501;anti-HIV_048-204221; anti-HIV_048-204015; anti-HIV_048-201240;anti-HIV_048-200455; anti-HIV_048-200319; anti-HIV_048-197896;anti-HIV_048-193813; anti-HIV_048-192098; anti-HIV_048-191786;anti-HIV_048-188746; anti-HIV_048-185937; anti-HIV_048-184849;anti-HIV_048-183089; anti-HIV_048-181509; anti-HIV_048-180990;anti-HIV_048-177532; anti-HIV_048-177426; anti-HIV_048-177389;anti-HIV_048-174266; anti-HIV_048-172847; anti-HIV_048-172845;anti-HIV_048-172363; anti-HIV_048-171609; anti-HIV_048-170705;anti-HIV_048-168381; anti-HIV_048-166619; anti-HIV_048-162036;anti-HIV_048-160042; anti-HIV_048-159676; anti-HIV_048-159500;anti-HIV_048-159421; anti-HIV_048-159333; anti-HIV_048-158932;anti-HIV_048-155811; anti-HIV_048-155464; anti-HIV_048-155392;anti-HIV_048-155389; anti-HIV_048-154449; anti-HIV_048-153379;anti-HIV_048-153171; anti-HIV_048-152324; anti-HIV_048-146102;anti-HIV_048-145984; anti-HIV_048-145371; anti-HIV_048-144907;anti-HIV_048-142298; anti-HIV_048-142277; anti-HIV_048-141934;anti-HIV_048-141207; anti-HIV_048-140796; anti-HIV_048-139893;anti-HIV_048-138820; anti-HIV_048-135858; anti-HIV_048-134968;anti-HIV_048-134312; anti-HIV_048-132253; anti-HIV_048-130710;anti-HIV_048-128564; anti-HIV_048-126702; anti-HIV_048-124521;anti-HIV_048-122740; anti-HIV_048-119536; anti-HIV_048-116929;anti-HIV_048-116577; anti-HIV_048-116046; anti-HIV_048-115875;anti-HIV_048-115599; anti-HIV_048-113988; anti-HIV_048-112989;anti-HIV_048-112435; anti-HIV_048-111339; anti-HIV_048-111055;anti-HIV_048-111027; anti-HIV_048-109721; anti-HIV_048-109666;anti-HIV_048-109196; anti-HIV_048-109051; anti-HIV_048-108570;anti-HIV_048-108033; anti-HIV_048-107279; anti-HIV_048-106271;anti-HIV_048-106054; anti-HIV_048-104848; anti-HIV_048-104638;anti-HIV_048-104567; anti-HIV_048-102804; anti-HIV_048-101676;anti-HIV_048-097603; anti-HIV_048-097107; anti-HIV_048-096871;anti-HIV_048-096668; anti-HIV_048-095236; anti-HIV_048-094155;anti-HIV_048-093219; anti-HIV_048-092976; anti-HIV_048-090866;anti-HIV_048-090650; anti-HIV_048-089009; anti-HIV_048-088654;anti-HIV_048-086513; anti-HIV_048-086024; anti-HIV_048-085857;anti-HIV_048-084277; anti-HIV_048-084245; anti-HIV_048-082487;anti-HIV_048-081787; anti-HIV_048-081062; anti-HIV_048-079639;anti-HIV_048-079126; anti-HIV_048-073118; anti-HIV_048-070264;anti-HIV_048-069426; anti-HIV_048-068564; anti-HIV_048-068345;anti-HIV_048-067337; anti-HIV_048-067180; anti-HIV_048-063017;anti-HIV_048-061885; anti-HIV_048-061671; anti-HIV_048-060700;anti-HIV_048-060592; anti-HIV_048-060300; anti-HIV_048-059141;anti-HIV_048-057777; anti-HIV_048-056928; anti-HIV_048-056131;anti-HIV_048-055864; anti-HIV_048-055094; anti-HIV_048-054343;anti-HIV_048-054193; anti-HIV_048-052521; anti-HIV_048-049037;anti-HIV_048-048720; anti-HIV_048-048542; anti-HIV_048-047777;anti-HIV_048-046841; anti-HIV_048-046202; anti-HIV_048-046059;anti-HIV_048-043568; anti-HIV_048-042713; anti-HIV_048-042440;anti-HIV_048-040511; anti-HIV_048-039195; anti-HIV_048-036935;anti-HIV_048-034478; anti-HIV_048-031641; anti-HIV_048-029760;anti-HIV_048-027970; anti-HIV_048-027337; anti-HIV_048-027217;anti-HIV_048-026760; anti-HIV_048-024800; anti-HIV_048-024313;anti-HIV_048-021748; anti-HIV_048-020991; anti-HIV_048-020340;anti-HIV_048-019993; anti-HIV_048-019947; anti-HIV_048-017871;anti-HIV_048-015931; anti-HIV_048-015920; anti-HIV_048-013898;anti-HIV_048-013429; anti-HIV_048-012358; anti-HIV_048-011158;anti-HIV_048-010720; anti-HIV_048-009445; anti-HIV_048-006126;anti-HIV_048-005652; anti-HIV_048-005532; anti-HIV_048-005189;anti-HIV_048-005088; anti-HIV_048-004023; anti-HIV_048-001580;anti-HIV_038-221120; anti-HIV_038-197677; anti-HIV_038-196765;anti-HIV_038-186200; anti-HIV_038-126170; anti-HIV_038-108545;anti-HIV_038-107263; anti-HIV_038-104530; anti-HIV_038-099169;anti-HIV_038-075067; anti-HIV_038-072368; anti-HIV_038-068503;anti-HIV_038-068016; anti-HIV_038-063958; anti-HIV_038-033733;anti-HIV_038-030557; anti-HIV_038-024298; anti-HIV_038-011154;anti-HIV_5CIN; anti-HIV_5CIL; anti-HIV_5CIP; anti-HIV_4JKP;anti-HIV_3TNN; anti-HIV_3BQU; anti-HIV_IgG; anti-HIV_4P9M;anti-HIV_4P9H; anti-HIV_Ig; anti-HIV; anti-influenza;anti-influenza_Apo; anti-influenza-A; anti-OX40.

Preferably, the antibody or the fragment of variant thereof, which isencoded by the at least one coding sequence of the RNA according to thepresent invention, is selected from the group consisting of antibodieshaving an amino acid sequence according to any of the amino acidsequences SEQ ID NO: 1-7642, 61212-61214, 61236-61238, 61245-61247,61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332,61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385,61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457,61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494,61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544,61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606,61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645,61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708,61711, 61719, 61722, 61730 or a fragment or variant of any one of saidamino acid sequences.

The at least one coding sequence of the RNA according to the inventionpreferably comprises a nucleic acid sequence encoding a full-lengthantibody or a full-length variant of an antibody as defined herein. Theterm ‘full-length antibody’ or ‘full-length variant of an antibody’ asused herein typically refers to an antibody that substantially comprisesthe entire amino acid sequence of the antibody. For example, the RNApreferably comprises a nucleic acid sequence encoding all chains of theantibody, in particular if the antibody comprises more than one chain (a“multiple-chain antibody”).

It is also preferred that the at least one coding sequence of the RNAaccording to the invention comprises a nucleic acid sequence encoding afragment of an antibody. In the context of the present invention, a‘fragment’ of an antibody or of a variant thereof may comprise asequence of an antibody or of a variant thereof as defined herein, whichis, with regard to its amino acid sequence (or its encoded nucleic acidsequence), N-terminally, C-terminally and/or intrasequentially truncatedcompared to the amino acid sequence of the full-length antibody or avariant thereof (or its encoded nucleic acid sequence). Such truncationmay thus occur either on the amino acid level or on the nucleic acidlevel, respectively. A sequence identity with respect to such a fragmentas defined herein therefore preferably refers to the entire antibody ora variant thereof as defined herein or to the entire (coding) nucleicacid sequence of such an antibody or of a variant thereof.

Preferably, a fragment or a variant of an antibody is a functionalfragment or a functional variant, which comprises at least onefunctional CDR of the corresponding antibody capable of recognizing (andbinding to) an antigen.

Such a fragment has preferably a length of at least 3 amino acids. Morepreferably, such a fragment has a length of at least 4, 5, 6, 7, 8, 9,10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 amino acids.

Examples of such antibody fragments are any antibody fragments known toa person skilled in the art, e.g. Fab, Fab′, F(ab′)₂, Fc, Facb, pFc′,Fd, and Fv fragments of the abovementioned antibodies etc. A diagram ofthe structure of such exemplified antibody fragments is shown by way ofexample in FIG. 4 . For example, a Fab (fragment antigen binding)fragment typically comprises the variable and a constant domain of alight and a heavy chain, e.g. the C_(H)1 and the V_(H) domain of theheavy chain and the complete light chain. The two chains are bonded toone another via a disulfide bridge. A Fab fragment thus conventionallycontains the complete antigen-binding region of the original antibodyand usually has the same affinity for the antigen, the immunogen or anepitope of a protein. Antibody fragments, as also described above forantibodies, can be prepared with the aid of molecular biology methods.In this context, the DNA sequences which code for the various domains ofthe antibody fragment are cloned into a specific expression vector. TheRNA which codes for these antibody fragments can then be expressed e.g.in suitable host cells. Suitable host cells in connection with thepresent invention include, inter alia, E. coli, yeasts, transgenicplants or mammalian cells etc. (see below). Moreover, antibody fragmentsconsisting of the minimal binding subunit of antibodies are known assingle-chain antibodies (scFvs) and have excellent binding specificityand affinity for their ligands. An scFv fragment (single chain variablefragment) typically comprises the variable domain of the light and ofthe heavy chain, which are bonded to one another via an artificialpolypeptide linker. In the cloning of such scFv fragments, RNAs whichcode for a V_(H) and V_(L), these being linked to one another by apolypeptide linker, are preferably provided. As a rule, a polypeptidebuilt up from 15-25 glycine, proline and/or serine residues (cf. FIG. 5) or the associated nucleotide sequence is used at the RNA level for theprovision of this component.

Preferably, the antibody fragment, which is encoded by the codingsequence of the RNA according to the invention, is an antigen-bindingfragment. Such an antigen-binding fragment typically comprises at leastone CDR. More preferably, the antibody fragment, which is encoded by thecoding sequence of the RNA according to the invention, comprises a heavychain variable region (V_(H)) and/or a light chain variable region(V_(L)). Even more preferably, the antibody fragment, which is encodedby the coding sequence of the RNA according to the invention, comprisesa complete (full-length) heavy chain or a complete (full-length) lightchain of an antibody.

It is also preferred that the RNA comprises at least one coding sequenceencoding a variant of an antibody as defined herein, or a fragment of avariant of an antibody. Preferably, such variants have the samebiological function as or, respectively, the specific activity of thecorresponding full length antibody or of the corresponding antibodyfragment, e.g. the specific binding of particular antigens or nucleicacids. Accordingly, it is preferred, if the hypervariable region(s) areconserved or are modified by merely conservative mutations.

The biological function of antibodies described here which are coded bythe RNA according to the invention includes e.g. neutralization ofantigens, complement activation or opsonization. In the case ofneutralization of antigens, the antibody can bind to an antigen andthereby neutralize this. The antibody is conventionally blocked by thebinding of the antigen, and can therefore display its action onlyagainst one antigen, or two antigens in the case of bispecificantibodies. scFv antibody fragments are suitable above all for this(neutralization) function of an antibody, since they do not include thefunctions of the constant domains of an antibody. In the case ofcomplement activation, the complex system of complement proteins whichare dependent upon the Fc part of the antibody can be activated viabinding of antibodies. End products of the complement cascade typicallylead to lysis of cells and to the creation of a phlogistic(inflammatory) milieu. In the case of opsonization, pathogens or foreignparticles are rendered accessible to phagocytes by binding by anantibody via the constant domains of the antibody. Alternatively, theopsonized cells, which are recognized as foreign, can be lysed via anantibody-dependent, cell-mediated cytotoxicity (ADCC). In this context,NK cells in particular can perform lytic functions in this manner viaactivation of their Fc receptors.

In certain embodiments of the present invention, a ‘variant’ of anantibody or a fragment thereof as defined herein may be encoded by theRNA comprising at least one coding sequence as defined herein, whereinthe amino acid sequence encoded by the at least one coding sequencediffers in at least one amino acid residue from the antibody's referenceamino acid sequence. Exemplified reference amino acid sequences ofantibodies are shown below in Table 3.

In this context, the ‘change’ in at least one amino acid residue mayconsist, for example, in a mutation of an amino acid residue to anotheramino acid, a deletion or an insertion. More preferably, the term‘variant’ as used in the context of the amino acid sequence encoded bythe at least one coding sequence of the RNA according to the inventioncomprises any homolog, isoform or transcript variant of the antibody ora fragment thereof as defined herein, wherein the homolog, isoform ortranscript variant is preferably characterized by a degree of identityor homology, respectively, as defined herein.

Preferably, a variant of an antibody or a fragment thereof may beencoded by the RNA comprising at least one coding sequence as definedherein, wherein at least one amino acid residue of the amino acidsequence encoded by the at least one coding sequence is substituted.Substitutions, wherein amino acids, which originate from the same class,are exchanged for one another, are called conservative substitutions. Inparticular, these are amino acids having aliphatic side chains,positively or negatively charged side chains, aromatic groups in theside chains or amino acids, the side chains of which can form hydrogenbridges, e.g. side chains which have a hydroxyl function. Byconservative constitution, e.g. an amino acid having a polar side chainmay be replaced by another amino acid having a corresponding polar sidechain, or, for example, an amino acid characterized by a hydrophobicside chain may be substituted by another amino acid having acorresponding hydrophobic side chain (e.g. serine (threonine) bythreonine (serine) or leucine (isoleucine) by isoleucine (leucine)). Ina preferred embodiment, a variant of an antibody or a fragment thereofmay be encoded by the RNA according to the invention, wherein at leastone amino acid residue of the amino acid sequence encoded by the atleast one coding sequence comprises at least one conservativesubstitution compared to the respective reference sequence. These aminoacid sequences as well as their encoding nucleic acid sequences inparticular are comprised by the term ‘variant’ as defined herein.

Insertions, deletions and/or non-conservative substitutions are alsopossible, in particular, at those sequence positions, which cause nomodification to the three-dimensional structure or do not affect thebinding region. Modifications to a three-dimensional structure byinsertion(s) or deletion(s) can easily be determined e.g. using CDspectra (circular dichroism spectra) (Urry, 1985, Absorption, CircularDichroism and ORD of Polypeptides, in: Modern Physical Methods inBiochemistry, Neuberger et al. (ed.), Elsevier, Amsterdam).

In order to determine the percentage, to which two sequences (nucleicacid sequences, e.g. RNA or mRNA sequences as defined herein, or aminoacid sequences, preferably the amino acid sequence encoded by the RNAaccording to the invention) are identical, the sequences can be alignedin order to be subsequently compared to one another. For this purpose,e.g. gaps can be inserted into the sequence of the first sequence andthe component at the corresponding position of the second sequence canbe compared. If a position in the first sequence is occupied by the samecomponent as is the case at a corresponding position in the secondsequence, the two sequences are identical at this position. Thepercentage, to which two sequences are identical, is a function of thenumber of identical positions divided by the total number of positions.The percentage, to which two sequences are identical, can be determinedusing a mathematical algorithm. A preferred, but not limiting, exampleof a mathematical algorithm, which can be used is the algorithm ofKarlin et al. (1993), PNAS USA, 90:5873-5877 or Altschul et al. (1997),Nucleic Acids Res., 25:3389-3402. Such an algorithm is integrated, forexample, in the BLAST program. Sequences, which are identical to thesequences of the present invention to a certain extent, can beidentified by this program. Typically, “% sequence identity” iscalculated in respect to a reference sequence. Exemplified referencesequences in the context of the present invention are the sequencesaccording to SEQ ID NO: 1-61734, in particular the protein and RNAsequences shown in Table 3 below.

A fragment of an antibody or a variant thereof encoded by the at leastone coding sequence of the RNA according to the invention may typicallycomprise an amino acid sequence having a sequence identity of at least5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%,90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of atleast 70%, more preferably of at least 80%, even more preferably atleast 85%, even more preferably of at least 90% and most preferably ofat least 95% or even 97%, with an amino acid sequence of the respectivereference full-length antibody or a fragment thereof.

More preferably, a fragment of an antibody or a variant thereof encodedby the at least one coding sequence of the RNA according to theinvention may typically comprise or consist of an amino acid sequencehaving a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%,70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%,97%, 98%, or 99%, preferably of at least 70%, more preferably of atleast 80%, even more preferably at least 85%, even more preferably of atleast 90% and most preferably of at least 95% or even 97%, with an aminoacid sequence selected from the group consisting of SEQ ID NOs: 1-7642,61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281,61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357,61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426,61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476,61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516,61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573,61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619,61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675,61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, 61730; ora fragment or variant of any one of said amino acid sequences.

Most preferably, a fragment of an antibody or a variant thereof encodedby the at least one coding sequence of the RNA according to theinvention typically comprises or consists of an amino acid sequencehaving a sequence identity of at least 80% with an amino acid sequenceselected from the group consisting of SEQ ID NOs: 1-7642, 61212-61214,61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312,61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373,61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440,61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487,61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537,61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587,61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639,61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689,61697, 61700, 61708, 61711, 61719, 61722, 61730; or a fragment orvariant of any one of said amino acid sequences.

Without being limited thereto, according to the present invention RNAswhich code for antibodies inter alia code for those antibodies whichbind antigens or specific nucleic acids. Antigens in the context of thepresent invention are typically molecules which are recognized asexogenous by the immune system and conventionally cause an immunereaction or immune response with the formation of antibodies directedspecifically against them. However, antigens can also include,especially in the case of autoimmune diseases, endogenous molecules orstructures which are incorrectly recognized as exogenous by the immunesystem and thereby trigger an immune reaction. Alternatively formulated,antigens are therefore all molecules which are recognized by an antibodyin the context of the present invention. Antigens substantially compriseproteins, peptides or epitopes of these proteins or peptides. In thiscontext, epitopes (also called “antigenic determinants”) are typicallysmall regions (molecular sections) lying on the surface of such proteinor peptide structures and having a length of from 5 to 15, in rare casealso to 25, preferably 6 to 9 amino acids. Antigens can furthermore alsoinclude lipids, carbohydrates etc. In the context of the presentinvention, antigens also include, for example, so-called immunogens,i.e. antigens which lead to an immunity of the organism transfectedtherewith. Antigens by way of example include, without being limitedthereto, surface antigens of cells, tumour antigens etc. For example,according to the present invention antibodies can bind the followingantigens (which typically occur in vertebrates), e.g. tumour-specificsurface antigens (TSSA), e.g. 5T4, α5β1-integrin, 707-AP, AFP, ART-4,B7H4, BAGE, β-catenin/m, Bcr-abl, MN/C IX-antigen, CA125, CAMEL, CAP-1,CASP-8, CD4, CD19, CD20, CD22, CD25, CDC27/m, CD 30, CD33, CD52, CD56,CD80, CDK4/m, CEA, CT, Cyp-B, DAM, EGFR, ErbB3, ELF2M, EMMPRIN, EpCam,ETV6-AML1, G250, GAGE, GnT-V, Gp100, HAGE, HER-2/neu, HLA-A*0201-R170I,HPV-E7, HSP70-2M, HAST-2, hTERT (or hTRT), iCE, IGF-1R, IL-2R, IL-5,KIAA0205, LAGE, LDLR/FUT, MAGE, MART-1/Melan-A, MART-2/Ski, MC1R,myosin/m, MUC1, MUM-1, -2, -3, NA88-A, NY-ESO1, PAP, proteinase-3, p190minor bcr-abl, Pml/RARα, PRAME, PSA, PSM, PSMA, RAGE, RU1 or RU2, SAGE,SART-1 or SART-3, survivin, TEL/AML1, TGFβ, TPI/m, TRP-1, TRP-2,TRP-2/INT2, VEGF and WT1, or sequences, such as e.g. NY-Eso-1 orNY-Eso-B. Tumour antigens can, for example, typically be responsible formetastasing, that is to say dissolving of tumour cells out of theirnative tissue, transfer into the vascular system (lymph or blood vesselsystem), exit from the vascular system and colonization in a new tissue.In this context, such tumour antigens which cause modified cell-cellinteractions compared with the native state are of interest inparticular.

Antibodies encoded by the inventive RNA may also be directed againsttumour antigens listed by Table 1 or Table 2. In particular, RNAencoding those antibodies may be used to treat (or, may be used toprepare a medicament to treat, respectively) the cancer diseases givenin the last column of Tables 1 and 2.

TABLE 1 Antigens expressed in cancer diseases Tumor antigen Name oftumor antigen Cancers or cancer diseases related thereto 5T4 colorectalcancer, gastric cancer, ovarian cancer 707-AP 707 alanine prolinemelanoma 9D7 renal cell carcinoma AFP alpha-fetoprotein hepatocellularcarcinoma, gallbladder cancer, testicular cancer, ovarian cancer,bladder cancer AlbZIP HPG1 prostate cancer alpha5beta1-Integrinalpha5beta6-Integrin colon cancer alpha-methylacyl-coenzyme prostatecancer A racemase ART-4 adenocarcinoma antigen lung cancer, head andneck cancer, leukemia, esophageal recognized by T cells 4 cancer,gastric cancer, cervical cancer, ovarian cancer, breast cancer, squamouscell carcinoma B7H4 ovarian cancer BAGE-1 B antigen bladder cancer, headand neck cancer, lung cancer, melanoma, squamous cell carcinoma BCL-2leukemia BING-4 melanoma CA 15-3/CA 27-29 breast cancer, ovary cancer,lung cancer, prostate cancer CA 19-9 gastric cancer, pancreatic cancer,liver cancer, breast cancer, gallbladder cancer, colon cancer, ovarycancer, lung cancer CA 72-4 ovarian cancer CA125 ovarian cancer,colorectal cancer, gastric cancer, liver cancer, pancreatic cancer,uterus cancer, cervix carcinoma, colon cancer, breast cancer, lungcancer calreticulin bladder cancer CAMEL CTL-recognized antigen onmelanoma melanoma CASP-8 caspase-B head and neck cancer cathepsin Bbreast cancer cathepsin L breast cancer CD19 B-cell malignancies CD20CD22 CD25 CD30 CD33 CD4 CD52 CD55 CD56 CD80 CEA carcinoembryonic antigengut carcinoma, colorectal cancer, colon cancer, hepatocellular cancer,lung cancer, breast cancer, thyroid cancer, pancreatic cancer, livercancer cervix cancer, bladder cancer, melanoma CLCA2 calcium-activatedchloride channel-2 lung cancer CML2B leukemia Coactosin-like proteinpancreatic cancer Collagen XXIII prostate cancer COX-2 ovarian cancer,breast cancer, colorectal cancer CT-9/BRD6 bromodomain testis-specificprotein Cten C-terminal tensin-like protein prostate cancer cyclin B1cyclin D1 ovarian cancer cyp-B cyclophilin B bladder cancer, lungcancer, T-cell leukemia, squamous cell carcinoma, CYPB1 cytochrom P4501B1 leukemia DAM-10/MAGE-B1 differentiation antigen melanoma 10melanoma, skin tumors, ovarian cancer, lung cancer DAM-6/MAGE-B2differentiation antigen melanoma 6 melanoma, skin tumors, ovariancancer, lung cancer EGFR/Her1 lung cancer, ovarian cancer, head and neckcancer, colon cancer, pancreatic cancer, breast cancer EMMPRIN tumorcell-associated extracellular lung cancer, breast cancer, bladdercancer, ovarian cancer, matrix metalloproteinase inducer/ brain cancer,lymphoma EpCam epithelial cell adhesion molecule ovarian cancer, breastcancer, colon cancer, lung cancer EphA2 ephrin type-A receptor 2 gliomaEphA3 ephrin type-A receptor 2 melanoma, sarcoma, lung cancer ErbB3breast cancer EZH2 (enhancer of Zeste homolog 2) endometrium cancer,melanoma, prostate cancer, breast cancer FGF-5 fibroblast growthfactor-5 renal cell carcinoma, breast cancer, prostate cancer FNfibronectin melanoma Fra-1 Fos-related antigen-1 breast cancer,esophageal cancer, renal cell carcinoma, thyroid cancer G250/CAIXglycoprotein 250 leukemia, renal cell carcinoma, head and neck cancer,colon cancer, ovarian cancer, cervical cancer GAGE-1 G antigen 1 bladdercancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-2 Gantigen 2 bladder cancer, lung cancer, sarcoma, melanoma, head and neckcancer GAGE-3 G antigen 3 bladder cancer, lung cancer, sarcoma,melanoma, head and neck cancer GAGE-4 G antigen 4 bladder cancer, lungcancer, sarcoma, melanoma, head and neck cancer GAGE-5 G antigen 5bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancerGAGE-6 G antigen 6 bladder cancer, lung cancer, sarcoma, melanoma, headand neck cancer GAGE-7b G antigen 7b bladder cancer, lung cancer,sarcoma, melanoma, head and neck cancer GAGE-8 G antigen 8 bladdercancer, lung cancer, sarcoma, melanoma, head and neck cancer GDEP genedifferentially expressed in prostate prostate cancer GnT-VN-acetylglucosaminyltransferase V glioma, melanoma gp100 glycoprotein100 kDa melanoma GPC3 glypican 3 hepatocellular carcinoma, melanoma HAGEhelicase antigen bladder cancer HAST-2 human signet ring tumor-2 hepsinprostate Her2/neu/ErbB2 human epidermal receptor-2/ breast cancer,bladder cancer, melanoma, ovarian cancer, neurological pancreas cancer,gastric cancer HERV-K-MEL melanoma HNE human neutrophil elastaseleukemia homeobox NKX 3.1 prostate cancer HOM-TES-14/SCP-1 ovariancancer HOM-TES-85 HPV-E6 cervical cancer HPV-E7 cervical cancer HST-2gastric cancer hTERT human telomerase reverse transcriptase breastcancer, melanoma, lung cancer, ovarian cancer, sarcoma,Non-Hodgkin-lymphoma, acute leukemia iCE intestinal carboxyl esteraserenal cell carcinoma IGF-1R colorectal cancer IL-13Ra2 interleukin 13receptor alpha 2 chain glioblastoma IL-2R colorectal cancer IL-5immature laminin receptor renal cell carcinoma kallikrein 2 prostatecancer kallikrein 4 prostate cancer Ki67 prostate cancer, breast cancer,Non-Hodgkin-lymphoma, melanoma KIAA0205 bladder cancer KK-LC-1Kita-kyushu lung cancer antigen 1 lung cancer KM-HN-1 tongue cancer,hepatocellular carcinomas, melanoma, gastric cancer, esophageal, coloncancer, pancreatic cancer LAGE-1 L antigen bladder cancer, head and neckcancer, melanoma livin bladder cancer, melanoma MAGE-A1 melanomaantigen-A1 bladder cancer, head and neck cancer, melanoma, colon cancer,lung cancer, sarcoma, leukemia MAGE-A10 melanoma antigen-A10 bladdercancer, head and neck cancer, melanoma, colon cancer, lung cancer,sarcoma, leukemia MAGE-A12 melanoma antigen-A12 bladder cancer, head andneck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia,prostate cancer, myeloma, brain tumors MAGE-A2 melanoma antigen-A2bladder cancer, head and neck cancer, melanoma, colon cancer, lungcancer, sarcoma, leukemia MAGE-A3 melanoma antigen-A3 bladder cancer,head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma,leukemia MAGE-A4 melanoma antigen-A4 bladder cancer, head and neckcancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-A6melanoma antigen-A6 bladder cancer, head and neck cancer, melanoma,colon cancer, lung cancer, sarcoma, leukemia MAGE-A9 melanoma-antigen-A9bladder cancer, head and neck cancer, melanoma, colon cancer, lungcancer, sarcoma, leukemia MAGE-B1 melanoma-antigen-B1 melanoma MAGE-B10melanoma-antigen-B10 melanoma MAGE-B16 melanoma-antigen-B16 melanomaMAGE-B17 melanoma-antigen-B17 melanoma MAGE-B2 melanoma-antigen-B2melanoma MAGE-B3 melanoma-antigen-B3 melanoma MAGE-B4melanoma-antigen-B4 melanoma MAGE-B5 melanoma-antigen-B5 melanomaMAGE-B6 melanoma-antigen-B6 melanoma MAGE-C1 melanoma-antigen-C1 bladdercancer, melanoma MAGE-C2 melanoma-antigen-C2 melanoma MAGE-C3melanoma-antigen-C3 melanoma MAGE-D1 melanoma-antigen-D1 melanomaMAGE-D2 melanoma-antigen-D2 melanoma MAGE-D4 melanoma-antigen-D4melanoma MAGE-E1 melanoma-antigen-E1 bladder cancer, melanoma MAGE-E2melanoma-antigen-E2 melanoma MAGE-F1 melanoma-antigen-F1 melanomaMAGE-H1 melanoma-antigen-H1 melanoma MAGEL2 MAGE-like 2 melanomamammaglobin A breast cancer MART-1/Melan-A melanoma antigen recognizedby melanoma T cells-1/melanoma antigen A MART-2 melanoma antigenrecognized by melanoma T cells-2 matrix protein 22 bladder cancer MCIRmelanocortin I receptor melanoma M-CSF macrophage colony-stimulatingovarian cancer factor gene mesothelin ovarian cancer MG5D/PXDN breastcancer, glioblastoma, melanoma MMP 11 M-phase phosphoprotein 11 leukemiaMN/CA IX-antigen renal cell carcinoma MRP-3 multidrugresistance-associated lung cancer protein 3 MUC1 mucin 1 breast cancerMUC2 mucin 2 breast cancer, ovarian cancer, pancreatic cancer NA 88-A NAcDNA clone of patient M88 melanoma N-acetylglucosaminyltransferase-VNeo-PAP Neo-poly(A) polymerase NGEP prostate cancer NMP22 bladder cancerNPM/ALK nucleophosmin/anaplastic lymphoma kinase fusion protein NSEneuron-specific enolase small cell cancer of lung, neuroblastoma, Wilm'tumor, melanoma, thyroid cancer, kidney cancer, testicle cancer,pancreas cancer NY-ESO-1 New York esophageous 1 bladder cancer, head andneck cancer, melanoma, sarcoma, B-lymphoma, hepatoma, pancreatic cancer,ovarian cancer, breast cancer NY-ESO-B OA1 ocular albinism type 1protein melanoma OFA-iLRP oncofetal antigen-immature leukemia lamininreceptor OGT O-linked N-acetylglucosamine transferase gene OS-9osteocalcin prostate cancer osteopontin prostate cancer, breast cancer,ovarian cancer p15 protein 15 p15 melanoma p190 minor bcr-abl p53 PAGE-4prostate GAGE-like protein-4 prostate cancer PAI-1 plasminogen acitvatorinhibitor 1 breast cancer PAI-2 plasminogen acitvator inhibitor 2 breastcancer PAP prostate acic phosphatase prostate cancer PART-1 prostatecancer PATE prostate cancer PDEF prostate cancer Pim-I-Kinase PinIPropyl isomerase prostate cancer PDTE prostate cancer PRAMEpreferentially expressed antigen of melanoma, lung cancer, leukemia,head and neck cancer, melanoma renal cell carcinoma, sarcoma prosteinprostate cancer proteinase-3 PSA prostate-specific antigen prostatecancer PSCA prostate cancer PSGR prostate cancer PSM PSMAprostate-specific membrane antigen prostate cancer RAGE-1 renal antigenbladder cancer, renal cancer, sarcoma, colon cancer RHAMM/CD168 receptorfor hyaluronic acid mediated leukemia motility RU1 renal ubiquitous 1bladder cancer, melanoma, renal cancer RU2 renal ubiquitous 1 bladdercancer, melanoma, sarcoma, brain tumor, esophagel cancer, renal cancer,colon cancer, breast cancer S-100 melanoma SAGE sarcoma antigen SART-1squamous antigen rejecting tumor 1 esophageal cancer, head and neckcancer, lung cancer, uterine cancer SART-2 squamous antigen rejectingtumor 1 head and neck cancer, lung cancer, renal cell carcinoma,melanoma, brain tumor SART-3 squamous antigen rejecting tumor 1 head andneck cancer, lung cancer, leukemia, melanoma, esophageal cancer SCCsquamous cell carcinoma antigen lung cancer Sp17 sperm protein 17multiple myeloma SSX-1 synovial sarcoma X breakpoint 1 hepatocellularcell carcinom, breast cancer SSX-2/HOM-MEL-40 synovial sarcoma Xbreakpoint 2 breast cancer SSX-4 synovial sarcoma X breakpoint 4 bladdercancer, hepatocellular cell carcinoma, breast cancer STAMP-1 prostatecancer STEAP six transmembrane epithelial antigen prostate cancerprostate survivin bladder cancer survivin-2B intron 2-retaining survivinbladder cancer TA-90 melanoma TAG-72 prostate carcinoma TARP prostatecancer TGFb TGFbeta TGFbRII TGFbeta receptor II TGM-4 prostate-specifictransglutaminase prostate cancer TRAG-3 taxol resistant associatedprotein 3 breast cancer, leukemia, and melanoma TRG testin-related geneTRP-1 tyrosine related protein 1 melanoma TRP-2/6b TRP-2/novel exon 6bmelanoma, glioblastoma TRP-2/INT2 TRP-2/intron 2 melanoma, glioblastomaTrp-p8 prostate cancer Tyrosinase melanoma UPA urokinase-typeplasminogen activator breast cancer VEGF vascular endothelial growthfactor VEGFR-2/FLK-1 vascular endothelial growth factor receptor-2 WTIWilm' tumor gene gastric cancer, colon cancer, lung cancer, breastcancer, ovarian cancer, leukemia

TABLE 2 Mutant antigens expressed in cancer diseases Mutant antigen Nameof mutant antigen Cancers or cancer diseases related theretoalpha-actinin-4/m lung carcinoma ARTC1/m melanoma bcr/abl breakpointcluster region-Abelson fusion protein CML beta-Catenin/m beta-Cateninmelanoma BRCA1/m breast cancer BRCA2/m breast cancer CASP-5/m colorectalcancer, gastric cancer, endometrial carcinoma CASP-8/m head and neckcancer, squamous cell carcinoma CDC27/m cell-division-cycle 27 CDK4/mcyclin-dependent kinase 4 melanoma CDKN2A/m melanoma CML66 CML CDA-1/mcolorectal cancer DEK-CAN fusion protein AML EFTUD2/m melanoma ELF2/mElongation factor 2 lung squamous cell carcinoma ETV6-AML1 Ets variantgene6/acute myeloid leukemia 1 gene fusion ALL protein FN1/m fibronectin1 melanoma GPNMB/m melanoma HLA-A*0201-R170I arginine to isoleucineexchange at residue 170 of the renal cell carcinoma alpha-helix of thealpha2-domain in the HLA-A2 gene HLA-A11/m melanoma HLA-A2/m renal cellcarcinoma HSP70-2M heat shock protein 70-2 mutated renal cell carcinoma,melanoma, neuroblastoma KIAA0205/m bladder tumor K-Ras/m pancreaticcarcinoma, colorectal carcinoma LDLR-FUT LDR-Fucosyltransferase fusionprotein melanoma MART2/m melanoma ME1/m non-small cell lung carcinomaMUM-1/m melanoma ubiquitous mutated 1 melanoma MUM-2/m melanomaubiquitous mutated 2 melanoma MUM-3/m melanoma ubiquitous mutated 3melanoma Myosin class I/m melanoma neo-PAP/m melanoma NFYC/m lungsquamous cell carcinoma N-Ras/m melanoma OGT/m colorectal carcinomaOS-9/m melanoma p53/m Pml/RARa promyelocytic leukemia/retinoic acidreceptor alpha APL, PML PRDX5/m melanoma PTPRK/m receptor-typeprotein-tyrosine phosphatase kappa melanoma RBAF600/m melanoma SIRT2/mmelanoma SYT-SSX-1 synaptotagmin I/synovial sarcoma X fusion proteinsarcoma SYT-SSX-2 synaptotagmin I/synovial sarcoma X fusion proteinsarcoma TEL-AMLI translocation Ets-family leukemia/acute myeloid AMLleukemia I fusion protein TGFbRII TGFbeta receptor II colorectalcarcinoma TPI/m triosephosphate isomerase melanoma

In a preferred embodiment according to the invention, antibodies encodedby the inventive RNA are directed against the following (protein)antigens (whereby the RNA molecules may be used for the preparation of amedicament, e.g. a pharmaceutical composition or more preferably a(passive) vaccine in the meaning of the present inventino), are selectedfrom the group consisting of 5T4, 707-AP, 9D7, AFP, AlbZIP HPG1,alpha-5-beta-1-integrin, alpha-5-beta-6-integrin, alpha-actinin-4/m,alpha-methylacyl-coenzyme A racemase, ART-4, ARTC1/m, B7H4, BAGE-1,BCL-2, bcr/abl, beta-catenin/m, BING-4, BRCA1/m, BRCA2/m, CA 15-3/CA27-29, CA 19-9, CA72-4, CA125, calreticulin, CAMEL, CASP-8/m, cathepsinB, cathepsin L, CD19, CD20, CD22, CD25, CDE30, CD33, CD4, CD52, CD55,CD56, CD80, CDC27/m, CDK4/m, CDKN2A/m, CEA, CLCA2, CML28, CML66,COA-1/m, coactosin-like protein, collage XXIII, COX-2, CT-9/BRD6, Cten,cyclin B1, cyclin D1, cyp-B, CYPB1, DAM-10, DAM-6, DEK-CAN, EFTUD2/m,EGFR, ELF2/m, EMMPRIN, EpCam, EphA2, EphA3, ErbB3, ETV6-AML1, EZH2,FGF-5, FN, Frau-1, G250, GAGE-1, GAGE-2, GAGE-3, GAGE-4, GAGE-5, GAGE-6,GAGE7b, GAGE-8, GDEP, GnT-V, gp100, GPC3, GPNMB/m, HAGE, HAST-2, hepsin,Her2/neu, HERV-K-MEL, HLA-A*0201-R17I, HLA-A11/m, HLA-A2/m, HNE,homeobox NKX3.1, HOM-TES-14/SCP-1, HOM-TES-85, HPV-E6, HPV-E7, HSP70-2M,HST-2, hTERT, iCE, IGF-1R, IL-13Ra2, IL-2R, IL-5, immature lamininreceptor, kallikrein-2, kallikrein-4, Ki67, KIAA0205, KIAA0205/m,KK-LC-1, K-Ras/m, LAGE-A1, LDLR-FUT, MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4,MAGE-A6, MAGE-A9, MAGE-A10, MAGE-A12, MAGE-B1, MAGE-B2, MAGE-B3,MAGE-B4, MAGE-B5, MAGE-B6, MAGE-B10, MAGE-B16, MAGE-B17, MAGE-C1,MAGE-C2, MAGE-C3, MAGE-D1, MAGE-D2, MAGE-D4, MAGE-E1, MAGE-E2, MAGE-F1,MAGE-H1, MAGEL2, mammaglobin A, MART-1/melan-A, MART-2, MART-2/m, matrixprotein 22, MC1R, M-CSF, ME1/m, mesothelin, MG50/PXDN, MMP11, MN/CAIX-antigen, MRP-3, MUC-1, MUC-2, MUM-1/m, MUM-2/m, MUM-3/m, myosin classI/m, NA88-A, N-acetylglucosaminyltransferase-V, Neo-PAP, Neo-PAP/m,NFYC/m, NGEP, NMP22, NPM/ALK, N-Ras/m, NSE, NY-ESO-1, NY-ESO-B, OA1,OFA-iLRP, OGT, OGT/m, OS-9, OS-9/m, osteocalcin, osteopontin, p15, p190minor bcr-abl, p53, p53/m, PAGE-4, PAI-1, PAI-2, PART-1, PATE, PDEF,Pim-1-Kinase, Pin-1, Pml/PARalpha, POTE, PRAME, PRDX5/m, prostein,proteinase-3, PSA, PSCA, PSGR, PSM, PSMA, PTPRK/m, RAGE-1, RBAF600/m,RHAMM/CD168, RU1, RU2, S-100, SAGE, SART-1, SART-2, SART-3, SCC,SIRT2/m, Sp17, SSX-1, SSX-2/HOM-MEL-40, SSX-4, STAMP-1, STEAP, survivin,survivin-2B, SYT-SSX-1, SYT-SSX-2, TA-90, TAG-72, TARP, TEL-AML1,TGFbeta, TGFbetaRII, TGM-4, TPI/m, TRAG-3, TRG, TRP-1, TRP-2/6b,TRP/INT2, TRP-p8, tyrosinase, UPA, VEGF, VEGFR-2/FLK-1, and WT1.

In a particularly preferred embodiment, the RNA codes for antibodieswhich are directed against protein antigens selected from the groupconsisting of MAGE-A1, MAGE-A6, melan-A, GP100, tyrosinase, survivin,CEA, Her-2/neu, WT1, PRAME, EGFRI (epidermal growth factor receptor 1),mucin-1 and SEC61G, hTERT, 5T4, NY-Eso1, and TRP-2, more preferably fromsequences of group consisting of MAGE-A1 [accession number M77481],MAGE-A6 [accession number NM_005363], melan-A [accession numberNM_005511], GP100 [accession number M77348], tyrosinase [accessionnumber NM_000372], survivin [accession number AF077350], CEA [accessionnumber NM_004363], Her-2/neu [accession number M11730], WT1 [accessionnumber NM_000378], PRAME [accession number NM_006115], EGFRI (epidermalgrowth factor receptor 1) [accession number AF288738], mucin-1[accession number NM_002456] and SEC61G [accession number NM_014302],hTERT [accession number NM_198253], 5T4 [accession number NM_006670],NY-Eso1 [accession number NM_001327], and TRP-2 [accession numberNM_001922].

Antibodies (and therefore also the RNAs according to the invention onwhich these antibodies are based) which bind the antigens described hereand, possibly, other antigens or nucleic acids can be identified e.g. bymeans of the method of phage display developed by George P. Smith. Inthis context, antibodies or antibody fragments are typically expressedon the surface of filamentous phages (Smith, G. P., 1985, “Filamentousfusion phage: novel expression vectors that display cloned antigens onthe virion surface”, Science 228; 1315-1317). For this there areconventionally 3 to 5 copies of the surface protein gpIII on theproximal end of the phage, with the aid of which the phage infectsbacteria cells via the F pilus thereof. In phage display, for example,the DNA for an antibody fragment which codes the antigen-bindingvariable domain is then cloned in-frame before the gplll gene. Inprotein biosynthesis, a fusion protein is formed therefrom, which isexpressed on the virus surface without the phage losing itsinfectiousness. With the aid of the phage display technique, it ispossible to generate large antibody libraries, each phage expressing adifferent antibody fragment on the surface. To this extent, theunderlying RNA is therefore also available. A particular antibodyfragment can be isolated from such a library by a method called “phagepanning”. For this, the corresponding antigen is bound to a matrix andincubated with the phage suspension. The phages which present anappropriate antibody fragment interact with the fixed antigen, while theother phages are removed by a washing step. The phages isolated aremultiplied, for example, in E. coli. The DNA is isolated accordingly andthe gene sequence is determined. Expression constructs which contain thecDNA coding for the entire antibody or antibody fragments can then bedeveloped with the aid of genetic engineering methods. An RNA (mRNA)which codes for the antibody can be generated from this cDNA by means ofin vitro transcription (see below). Nucleic acids or, respectively, mRNAcoding for monoclonal antibodies which are entirely of human origin areobtained in this manner.

In the context of the present invention, RNA according to the inventionwhich codes for antibodies as described above is also suitable forcoding so-called intrabodies or for rendering possible an expression ofintrabodies. Intrabodies in the context of the present invention caninclude any of the antibodies or antibody fragments described here.Intrabodies are intracellularly expressed antibodies, i.e. antibodieswhich are coded by nucleic acids localized in the cell and are expressedthere. For this, an RNA according to the invention which encodes theantibodies or antibody fragments as described above is introduced intocells beforehand, for example with the aid of transfection methodsaccording to the invention or other suitable transfection methods and,where appropriate, thereafter transplanted into an organism or being orintroduced directly as nucleic acids into an organism or being. In thiscontext (irrespective of whether an intrabody or a secreted antibodyshall be introduce into the cell), the RNA according to the invention(or a corresponding nucleic acid) can be introduced in the naked form oras a complex with suitable carriers (e.g. liposomes) into the organismor the being or can have such modifications (of the RNA) which, whereappropriate together with one of the transfection methods mentioned,lead to a better cell uptake, e.g. any of the RNA modificationsmentioned here, such as, for example, lipid modifications of the RNAaccording to the invention. An organism or a being in connection withthe present invention typically means mammals, i.e. animals, includingcattle, pig, dog, cat, donkey, monkey, rodents, e.g. mouse, hamster,rabbit etc., and humans. Intrabodies can be localized and expressed atcertain sites in the cell. For example, intrabodies can be expressed inthe cytoplasm, the formation of disulfide bridges usually beingdecreased under the reducing conditions of the cytoplasm. It has beenpossible to demonstrate, however, that cytoplasmic intrabodies, and inparticular scFv fragments, can be functional. Cytoplasmic expression bythe RNA according to the invention opens up the possibility of alsoinhibiting cytoplasmic proteins. This is not possible with treatmentwith monoclonal antibodies from the prior art, since these antibodiescan reach only secreted and membrane-located (extracellular) proteinsdue to their secretion from the cell after intracellular expression(which represents the major difference between antibodies andintrabodies). By expression of a signal peptide, intrabodies can betransported into the endoplasmic reticulum (ER) and then secreted aswith regular antibodies. In this case, typically only secreted ormembrane-located proteins are a target for these antibodies. Byadditional coding of a C-terminal ER retention signal (for example KDEL)by the RNA according to the invention, the intrabody can remain in theER (where it may bind to specific antigen located in the ER) and preventsecretion of its antigen and/or transport of its antigen or its targetmolecule to the plasma membrane. Depending on the requirement,intrabodies can include full length antibodies or antibody fragments asdescribed above. Intrabodies in the context of the present inventionpreferably initially include full length antibodies, which are retainedin the cell and not secreted from the cell (by whatever technique, e.g.retention signal sequences etc.). However, if e.g. intracellularexpression of full length antibodies is technically not possible or notappropriate, antibody fragments as described above can also be employedas intrabodies.

Preferably, the antibody encoded by the at least one coding sequence ofthe RNA is an antibody as defined herein, which is encoded by a nucleicacid sequence selected from the group consisting of SEQ ID NOs:7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242,61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321,61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358,61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404,61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491,61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541,61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585,61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636,61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676,61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718,61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361,61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415,61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466,61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492,61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605,61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615,61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710,61721, 61732, 61733, and 61734.

In a preferred embodiment, the present invention thus provides an RNAcomprising at least one coding sequence, wherein the coding sequencecomprises a nucleic acid sequence selected from the group consisting ofnucleic acid sequences according to SEQ ID NOs: 7643-61136, 61161-61175,61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275,61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336,61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371,61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427,61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467,61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497,61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558,61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604,61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642,61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687,61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729,61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322,61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404,61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428,61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473,61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520,61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608,61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733,and 61734; or a fragment or variant of any one of said nucleic acidsequences.

In certain embodiments, the RNA according to the invention, preferablythe at least one coding sequence of the RNA according to the invention,may comprise or consist of a fragment of a nucleic acid sequenceencoding an antibody or a fragment or variant thereof as defined herein.Preferably, the RNA according to the invention, preferably the at leastone coding sequence of the RNA according to the invention, comprises orconsists of a fragment of a nucleic acid sequence selected from thegroup consisting of SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211,61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302,61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380,61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436,61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473,61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514,61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563,61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607,61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642,61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687,61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729,61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322,61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404,61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428,61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473,61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520,61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608,61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733,and 61734; or of a variant of any one of said nucleic acid sequences.

In this context, a ‘fragment of a nucleic acid sequence’ is preferably anucleic acid sequence encoding a fragment of an antibody or of a variantthereof as described herein. More preferably, the expression ‘fragmentof a nucleic acid sequence’ refers to a nucleic acid sequence having asequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%,80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%,98%, or 99%, preferably of at least 70%, more preferably of at least80%, even more preferably at least 85%, even more preferably of at least90% and most preferably of at least 95% or even 97%, with a respectivefull-length nucleic acid sequence.

In another preferred embodiment, the RNA according to the invention,preferably the at least one coding sequence of the RNA according to theinvention, may comprise or consist of a variant of a nucleic acidsequence as defined herein, preferably of a nucleic acid sequenceencoding an antibody or a fragment thereof as defined herein. Theexpression ‘variant of a nucleic acid sequence’ as used herein in thecontext of a nucleic acid sequence encoding an antibody or a fragmentthereof, typically refers to a nucleic acid sequence, which differs byat least one nucleic acid residue from the respective reference nucleicacid sequence encoding an antibody or a fragment thereof. Morepreferably, the expression ‘variant of a nucleic acid sequence’ refersto a nucleic acid sequence having a sequence identity of at least 5%,10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%,91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least70%, more preferably of at least 80%, even more preferably at least 85%,even more preferably of at least 90% and most preferably of at least 95%or even 97%, with a nucleic acid sequence, from which it is derived.

Preferably, the RNA according to the invention, more preferably the atleast one coding sequence of the RNA according to the invention, encodesa variant of an antibody or a fragment thereof, preferably as definedherein.

In a preferred embodiment, the RNA according to the invention, morepreferably the at least one coding sequence of the RNA according to theinvention, comprises or consists of a variant of a nucleic acid sequenceencoding an antibody or a fragment thereof as defined herein, whereinthe variant of the nucleic acid sequence encodes an amino acid sequencecomprising at least one conservative substitution of an amino acidresidue.

In another embodiment, the RNA according to the invention, morepreferably the at least one coding sequence of the RNA according to theinvention, comprises or consists of a variant of a nucleic acid sequenceencoding an antibody or a fragment thereof as defined herein, whereinthe nucleic acid sequence of the variant differs from the respectivereference nucleic acid sequence in at least one nucleic acid residue,preferably without resulting—due to the degenerated genetic code—in analteration of the encoded amino acid sequence, i.e. the amino acidsequence encoded by the variant or at least part thereof may preferablynot differ from the reference amino acid sequence in one or moremutation(s) within the above meaning.

Furthermore, a ‘variant’ of a nucleic acid sequence encoding an antibodyor a fragment or variant thereof as defined herein, may also compriseDNA sequences, which correspond to RNA sequences as defined herein andmay also comprise further RNA sequences, which correspond to DNAsequences as defined herein. Those skilled in the art are familiar withthe translation of an RNA sequence into a DNA sequence (or vice versa)or with the creation of the complementary strand sequence (i.e. bysubstitution of U residues with T residues and/or by constructing thecomplementary strand with respect to a given sequence).

According to a preferred embodiment, the at least one coding sequence ofthe RNA according to the invention comprises or consists of a nucleicacid sequence having a sequence identity of at least 5%, 10%, 20%, 30%,40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%,94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, morepreferably of at least 80%, even more preferably at least 85%, even morepreferably of at least 90% and most preferably of at least 95% or even97%, with a nucleic acid sequence encoding a reference full-lengthantibody as defined herein, or a variant thereof.

In a further preferred embodiment, the at least one coding sequence ofthe RNA according to the invention comprises or consists of a nucleicacid sequence having a sequence identity of at least 5%, 10%, 20%, 30%,40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%,94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, morepreferably of at least 80%, even more preferably at least 85%, even morepreferably of at least 90% and most preferably of at least 95% or even97%, with a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 7643-61136, 61161-61175, 61209-61211, 61215-61235,61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347,61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382,61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438,61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479,61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519,61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615,61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664,61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707,61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244,61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337,61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410,61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485,61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586,61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612,61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677,61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment orvariant of any one of said nucleic acid sequences.

According to a particularly preferred embodiment, the at least onecoding sequence of the RNA according to the invention comprises orconsists of a nucleic acid sequence having a sequence identity of atleast 80% with a nucleic acid sequence selected from the groupconsisting of SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211,61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302,61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380,61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436,61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473,61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514,61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563,61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607,61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642,61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687,61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729,61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322,61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404,61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428,61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473,61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520,61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608,61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733,and 61734; or a fragment of any one of said nucleic acid sequences.

Table 3 below shows the assignment of amino acid sequences and RNAsequences of exemplified antibodies, which are preferably encoded by theRNA according to the present invention as described herein. Inparticular, the first column of Table 3 (“Name”) identifies (i) theantibody name and (ii) the antibody fragment (or complete antibody)encoded by the respective amino acid or RNA sequences, for example thechain (e.g., heavy chain, light chain, or any alternative/variantthereof) or the variable region. If the respective amino acid or RNAsequences encodes a fragment of a chain only (such as a certain regionof an antibody chain), this can be retrieved from the column “Name”. Inother words, unless otherwise indicated under “name”, the sequencesprovided relate to full length heavy or light chain sequences of therespective antibodies. However, it is also preferred that the codingsequence of the RNA according to the present invention encodes afragment or a variant of the antibody sequences (e.g. heavy chain orlight chain sequences) shown in Table 3 below.

TABLE 3 RNA and amino acid sequences of exemplified antibodies NameProtein SEQ ID NO RNA SEQ ID NO AAB-003_gamma1-Chain 1 7643, 15285,22927, 30569, 38211, 45853, 53495 Abagovomab_HeavyChain 2 7644, 15286,22928, 30570, 38212, 45854, 53496 Abagovomab_LightChain 3 7645, 15287,22929, 30571, 38213, 45855, 53497 Abciximab_HeavyChain 4 7646, 15288,22930, 30572, 38214, 45856, 53498 Abciximab_LightChain 5 7647, 15289,22931, 30573, 38215, 45857, 53499 Abituzumab_HeavyChain1 6 7648, 15290,22932, 30574, 38216, 45858, 53500 Abituzumab_LightChain1 7 7649, 15291,22933, 30575, 38217, 45859, 53501 Abrilumab_HeavyChain1 8 7650, 15292,22934, 30576, 38218, 45860, 53502 Abrilumab_LightChain1 9 7651, 15293,22935, 30577, 38219, 45861, 53503 Abrilumab_LightChain1_variant2 107652, 15294, 22936, 30578, 38220, 45862, 53504 Actoxumab_HeavyChain1 117653, 15295, 22937, 30579, 38221, 45863, 53505 Actoxumab_LightChain1 127654, 15296, 22938, 30580, 38222, 45864, 53506 Adalimumab_HeavyChain 137655, 15297, 22939, 30581, 38223, 45865, 53507 Adalimumab_LightChain 147656, 15298, 22940, 30582, 38224, 45866, 53508 Aducanumab_HeavyChain1 157657, 15299, 22941, 30583, 38225, 45867, 53509 Aducanumab_LightChain1 167658, 15300, 22942, 30584, 38226, 45868, 53510 Afasevikumab_HeavyChain117 7659, 15301, 22943, 30585, 38227, 45869, 53511Afasevikumab_LightChain1 18 7660, 15302, 22944, 30586, 38228, 45870,53512 Aflibercept_Fusion_protein1 19 7661, 15303, 22945, 30587, 38229,45871, 53513 Afutuzuab_HeavyChain1 20 7662, 15304, 22946, 30588, 38230,45872, 53514 Afutuzuab_LightChain1 21 7663, 15305, 22947, 30589, 38231,45873, 53515 Afutuzumab_HeavyChain1 22 7664, 15306, 22948, 30590, 38232,45874, 53516 Afutuzumab_LightChain1 23 7665, 15307, 22949, 30591, 38233,45875, 53517 Alacizumab_pegol_HeavyChain1 24 7666, 15308, 22950, 30592,38234, 45876, 53518 Alacizumab_pegol_LightChain1 25 7667, 15309, 22951,30593, 38235, 45877, 53519 Alemtuzumab_HeavyChain 26 7668, 15310, 22952,30594, 38236, 45878, 53520 Alemtuzumab_HeavyChain_variant_Ibey_H 277669, 15311, 22953, 30595, 38237, 45879, 53521Alemtuzumab_HeavyChain_variant_Icel_H 28 7670, 15312, 22954, 30596,38238, 45880, 53522 Alemtuzumab_HeavyChain_variant_8005_H 29 7671,15313, 22955, 30597, 38239, 45881, 53523 Alemtuzumab_LightChain 30 7672,15314, 22956, 30598, 38240, 45882, 53524Alemtuzumab_LightChain_variant_8005_L 31 7673, 15315, 22957, 30599,38241, 45883, 53525 Alirocumab_HeavyChain1 32 7674, 15316, 22958, 30600,38242, 45884, 53526 Alirocumab_LightChain1 33 7675, 15317, 22959, 30601,38243, 45885, 53527 ALX-0061_HeavyChain1 34 7676, 15318, 22960, 30602,38244, 45886, 53528 Amatuximab_HeavyChain1 35 7677, 15319, 22961, 30603,38245, 45887, 53529 Amatuximab_LightChain1 36 7678, 15320, 22962, 30604,38246, 45888, 53530 Anetumab_ravtansine_HeavyChain1 37 7679, 15321,22963, 30605, 38247, 45889, 53531 Anetumab_ravtansine_LightChain1 387680, 15322, 22964, 30606, 38248, 45890, 53532 Anifrolumab_HeavyChain139 7681, 15323, 22965, 30607, 38249, 45891, 53533Anifrolumab_LightChain1 40 7682, 15324, 22966, 30608, 38250, 45892,53534 Anrukinzumab_HeavyChain1 41 7683, 15325, 22967, 30609, 38251,45893, 53535 Anrukinzumab_LightChain1 42 7684, 15326, 22968, 30610,38252, 45894, 53536 Apolizumab_HeavyChain1 43 7685, 15327, 22969, 30611,38253, 45895, 53537 Apolizumab_LightChain1 44 7686, 15328, 22970, 30612,38254, 45896, 53538 Apomab_HeavyChain 45 7687, 15329, 22971, 30613,38255, 45897, 53539 Apomab_LightChain 46 7688, 15330, 22972, 30614,38256, 45898, 53540 Aquaporumab_LightChain 47 7689, 15331, 22973, 30615,38257, 45899, 53541 Arcitumomab_99tc_HeavyChain 48 7690, 15332, 22974,30616, 38258, 45900, 53542 Arcitumomab_99tc_LightChain 49 7691, 15333,22975, 30617, 38259, 45901, 53543 Ascrinvacumab_HeavyChain1 50 7692,15334, 22976, 30618, 38260, 45902, 53544 Ascrinvacumab_LightChain1 517693, 15335, 22977, 30619, 38261, 45903, 53545 Aselizuab_HeavyChain1 527694, 15336, 22978, 30620, 38262, 45904, 53546 Aselizuab_HeavyChain2 537695, 15337, 22979, 30621, 38263, 45905, 53547 Aselizuab_LightChain1 547696, 15338, 22980, 30622, 38264, 45906, 53548 Atezolizumab_HeavyChain155 7697, 15339, 22981, 30623, 38265, 45907, 53549Atezolizumab_LightChain1 56 7698, 15340, 22982, 30624, 38266, 45908,53550 Atinumab_HeavyChain1 57 7699, 15341, 22983, 30625, 38267, 45909,53551 Atinumab_LightChain1 58 7700, 15342, 22984, 30626, 38268, 45910,53552 Atlizuab_HeavyChain1 59 7701, 15343, 22985, 30627, 38269, 45911,53553 Atlizuab_LightChain1 60 7702, 15344, 22986, 30628, 38270, 45912,53554 Aurograb_SingleChain 61 7703, 15345, 22987, 30629, 38271, 45913,53555 Avelumab_HeavyChain1 62 7704, 15346, 22988, 30630, 38272, 45914,53556 Avelumab_LightChain1 63 7705, 15347, 22989, 30631, 38273, 45915,53557 Bapineuzumab_HeavyChain1 64 7706, 15349, 22990, 30632, 38274,45916, 53558 Bapineuzumab_LightChain1 65 7707, 15349, 22991, 30633,38275, 45917, 53559 Basiliximab_HeavyChain 66 7708, 15350, 22992, 30634,38276, 45918, 53560 Basiliximab_LightChain 67 7709, 15351, 22993, 30635,38277, 45919, 53561 Bavituximab_HeavyChain 68 7710, 15352, 22994, 30636,38278, 45920, 53562 Bavituximab_LightChain 69 7711, 15353, 22995, 30637,38279, 45921, 53563 Bavituximab_LightChain_variant_8734_L 70 7712,15354, 22996, 30638, 38280, 45922, 53564 Begelomab_HeavyChain1 71 7713,15355, 22997, 30639, 38281, 45923, 53565 Begelomab_LightChain1 72 7714,15356, 22998, 30640, 38282, 45924, 53566 Benralizumab_HeavyChain1 737715, 15357, 22999, 30641, 38283, 45925, 53567 Benralizumab_LightChain174 7716, 15358, 23000, 30642, 38284, 45926, 53568 Betalutin_HeavyChain175 7717, 15359, 23001, 30643, 38285, 45927, 53569 Betalutin_LightChain176 7718, 15360, 23002, 30644, 38286, 45928, 53570Bevacituzuab_HeavyChain1 77 7719, 15361, 23003, 30645, 38287, 45929,53571 Bevacituzuab_LightChain1 78 7720, 15362, 23004, 30646, 38288,45930, 53572 Bevacizumab_154-aspartic_acid_LightChain 79 7721, 15363,23005, 30647, 38289, 45931, 53573Bevacizumab_154-substitution_deriv_LightChain 80 7722, 15364, 23006,30648, 38290, 45932, 53574 Bevacizumab_180-serine_HeavyChain 81 7723,15365, 23007, 30649, 38291, 45933, 53575Bevacizumab_180-substitution_deriv_HeavyCahin 82 7724, 15366, 23008,30650, 38292, 45934, 53576 Bevacizumab_beta_HeavyChain1 83 7725, 15367,23009, 30651, 38293, 45935, 53577 Bevacizumab_beta_LightChain1 84 7726,15368, 23010, 30652, 38294, 45936, 53578 Bevacizumab_FcDomain 85 7727,15369, 23011, 30653, 38295, 45937, 53579 Bevacizumab_HeavyChain 86 7728,15370, 23012, 30654, 38296, 45938, 53580 Bevacizumab_HeavyChain_variant187 7729, 15371, 23013, 30655, 38297, 45939, 53581Bevacizumab_HeavyChain_V-Region 88 7730, 15372, 23014, 30656, 38298,45940, 53582 Bevacizumab_LightChain1 89 7731, 15373, 23015, 30657,38299, 45941, 53583 Bevacizumab_LightChain2 90 7732, 15374, 23016,30658, 38300, 45942, 53584 Bevacizumab_LightChain 91 7733, 15375, 23017,30659, 38301, 45943, 53585 Bevacizumab_LightChain_VJ-Region 92 7734,15376, 23018, 30660, 38302, 45944, 53586 Bevacizumab_LightChain_V-Region93 7735, 15377, 23019, 30661, 38303, 45945, 53587Bevacizumah-rhuMAb-VEGF_HeavyChain_gamma1- 94 7736, 15378, 23020, 30662,38304, 45946, 53588 Chain_VDJ-RegionBevacizumah-rhuMAb-VEGF_LightChain_VJ-Region 95 7737, 15379, 23021,30663, 38305, 45947, 53589 Bevacizumab_gamma1-Chain 96 7738, 15380,23022, 30664, 38306, 45948, 53590Bevacizumab_gamma1-Chain_CH3-Region_mutein 97 7739, 15381, 23023, 30665,38307, 45949, 53591 Bezlotoxumab_HeavyChain1 98 7740, 15382, 23024,30666, 38308, 45950, 53592 Bezlotoxumab_LightChain1 99 7741, 15383,23025, 30667, 38309, 45951, 53593 Bimagrumab_HeavyChain1 100 7742,15384, 23026, 30668, 38310, 45952, 53594 Bimagrumab_HeavyChain 101 7743,15385, 23027, 30669, 38311, 45953, 53595 Bimagrumab_LightChain1 1027744, 15386, 23028, 30670, 38312, 45954, 53596 Bimekizumab_HeavyChain1103 7745, 15387, 23029, 30671, 38313, 45955, 53597Bimekizumab_LightChain1 104 7746, 15388, 23030, 30672, 38314, 45956,53598 Bleselumab_HeavyChain1 105 7747, 15389, 23031, 30673, 38315,45957, 53599 Bleselumab_LightChain1 106 7748, 15390, 23032, 30674,38316, 45958, 53600 Blinatumomab_HeavyChain1 107 7749, 15391, 23033,30675, 38317, 45959, 53601 Blinatumomab_SingleChain 108 7750, 15392,23034, 30676, 38318, 45960, 53602Blinatumumab_SingleChain_variable_fragment_fusion_protein_(bite) 1097751, 15393, 23035, 30677, 38319, 45961, 53603 Blontuvetmab_HeavyChain110 7752, 15394, 23036, 30678, 38320, 45962, 53604Blontuvetmab_LightChain 111 7753, 15395, 23037, 30679, 38321, 45963,53605 Blosozumab_HeavyChain1 112 7754, 15396, 23038, 30680, 38322,45964, 53606 Blosozumab_LightChain1 113 7755, 15397, 23039, 30681,38323, 45965, 53607 Bococizumab_HeavyChain1 114 7756, 15398, 23040,30682, 38324, 45966, 53608 Bococizumab_LightChain1 115 7757, 15399,23041, 30683, 38325, 45967, 53609 Brentuximab_vedotin_HeavyChain1 1167758, 15400, 23042, 30684, 38326, 45968, 53610Brentuximab_vedotin_LightChain1 117 7759, 15401, 23043, 30685, 38327,45969, 53611 Briakinumab_HeavyChain1 118 7760, 15402, 23044, 30686,38328, 45970, 53612 Briakinumab_LightChain1 119 7761, 15403, 23045,30687, 38329, 45971, 53613 Brodalumab_HeavyChain1 120 7762, 15404,23046, 30688, 38330, 45972, 53614 Brodalumab_LightChain1 121 7763,15405, 23047, 30689, 38331, 45973, 53615 Brolucizumab_HeavyChain1 1227764, 15406, 23048, 30690, 38332, 45974, 53616 Brolucizuma_scFv_fragment123 7765, 15407, 23049, 30691, 38333, 45975, 53617Brontictuzumab_HeavyChain1 124 7766, 15408, 23050, 30692, 38334, 45976,53618 Brontictuzumab_LightChain1 125 7767, 15409, 23051, 30693, 38335,45977, 53619 BTT-1023_HeavyChain1 126 7768, 15410, 23052, 30694, 38336,45978, 53620 BTT-1023_LightChain1 127 7769, 15411, 23053, 30695, 38337,45979, 53621 Burosumab_HeavyChain1 128 7770, 15412, 23054, 30696, 38338,45980, 53622 Burosumab_LightChain1 129 7771, 15413, 23055, 30697, 38339,45981, 53623 Canakinumab_HeavyChain1 130 7772, 15414, 23056, 30698,38340, 45982, 53624 Canakinumab_HeavyChain 131 7773, 15415, 23057,30699, 38341, 45983, 53625 Canakinumab_LightChain1 132 7774, 15416,23058, 30700, 38342, 45984, 53626 Canakinumab_LightChain 133 7775,15417, 23059, 30701, 38343, 45985, 53627Canakinumab_LightChain_variant_8836_L 134 7776, 15418, 23060, 30702,38344, 45986, 53628 Cantuzumab_HeavyChain1 135 7777, 15419, 23061,30703, 38345, 45987, 53629 Cantuzumab_HeavyChain 136 7778, 15420, 23062,30704, 38346, 45988, 53630 Cantuzumab_LightChain1 137 7779, 15421,23063, 30705, 38347, 45989, 53631 Cantuzumab_mertansine_HeavyChain1 1387780, 15422, 23064, 30706, 38348, 45990, 53632Cantuzumab_mertansine_LightChain1 139 7781, 15423, 23065, 30707, 38349,45991, 53633 Cantuzumab_ravtansine_HeavyChain1 140 7782, 15424, 23066,30708, 38350, 45992, 53634 Cantuzumab_ravtansine_LightChain1 141 7783,15425, 23067, 30709, 38351, 45993, 53635 Caplacizumab 142 7784, 15426,23068, 30710, 38352, 45994, 53636 Caplacizumab_HeavyChain1 143 7785,15427, 23069, 30711, 38353, 45995, 53637 Caplacizumab_HeavyChain1 1447786, 15428, 23070, 30712, 38354, 45996, 53638 Carlumab_HeavyChain1 1457787, 15429, 23071, 30713, 38355, 45997, 53639 Carlumab_LightChain1 1467788, 15430, 23072, 30714, 38356, 45998, 53640Cergutuzumab_amunaleukin_HeavyChain1 147 7789, 15431, 23073, 30715,38357, 45999, 53641 Cergutuzumab_amunaleukin_HeavyChain2 148 7790,15432, 23074, 30716, 38358, 46000, 53642Cergutuzumab_amunaleukin_LightChain1 149 7791, 15433, 23075, 30717,38359, 46001, 53643 Certolizumab_pegol_HeavyChain1 150 7792, 15434,23076, 30718, 38360, 46002, 53644 Certolizumab_pegol_HeavyChain 1517793, 15435, 23077, 30719, 38361, 46003, 53645Certolizumab_pegol_LightChain1 152 7794, 15436, 23078, 30720, 38362,46004, 53646 Certolizumab_pegol_LightChain 153 7795, 15437, 23079,30721, 38363, 46005, 53647 Cetuximab_HeavyChain 154 7796, 15438, 23080,30722, 38364, 46006, 53648 Cetuximab_HeavyChain_variant 155 7797, 15439,23081, 30723, 38365, 46007, 53649 Cetuximab_LightChain 156 7798, 15440,23082, 30724, 38366, 46008, 53650 Cetuximab_LightChain_variant 157 7799,15441, 23083, 30725, 38367, 46009, 53651 Citatuzumab_bogatox_HeavyChain1158 7780, 15442, 23084, 30726, 38368, 46010, 53652Citatuzumab_bogatox_LightChain1 159 7801, 15443, 23085, 30727, 38369,46011, 53653 Cixutumumab_HeavyChain1 160 7802, 15444, 23086, 30728,38370, 46012, 53654 Cixutumumab_LightChain1 161 7803, 15445, 23087,30729, 38371, 46013, 53655 Clazakizumab_HeavyChain1 162 7804, 15446,23088, 30730, 38372, 46014, 53656 Clazakizumab_LightChain1 163 7805,15447, 23089, 30731, 38373, 46015, 53657Clivatuzumab_tetraxetan_HeavyChain1 164 7806, 15448, 23090, 30732,38374, 46016, 53658 Clivatuzumab_tetraxetan_LightChain1 165 7807, 15449,23091, 30733, 38375, 46017, 53659 Codrituzumab_HeavyChain1 166 7808,15450, 23092, 30734, 38376, 46018, 53660 Codrituzumab_LightChain1 1677809, 15451, 23093, 30735, 38377, 46019, 53661Coltuximab_ravtansine_HeavyChain1 168 7810, 15452, 23094, 30736, 38378,46020, 53662 Coltuximah_ravtansine_LightChain1 169 7811, 15453, 23095,30737, 38379, 46021, 53663 Conatumumab_CV_HeavyChain 170 7812, 15454,23096, 30738, 38380, 46022, 53664 Conatumumab_CV_LightChain 171 7813,15455, 23097, 30739, 38381, 46023, 53665 Conatumumab_HeavyChain1 1727814, 15456, 23098, 30740, 38382, 46024, 53666 Conatumumab_HeavyChain173 7815, 15457, 23099, 30741, 38383, 46025, 53667Conatumumab_LightChain1 174 7816, 15458, 23100, 30742, 38384, 46026,53668 Conatumumab_LightChain 175 7817, 15459, 23101, 30743, 38385,46027, 53669 Concizumab_HeavyChain1 175 7818, 15460, 23102, 30744,38386, 46028, 53670 Concizumab_LightChain1 177 7819, 15461, 23103,30745, 38387, 46029, 53671 Crenezumab_HeavyChain1 178 7820, 15462,23104, 30746, 38388, 46030, 53672 Crenezumab_LightChain1 179 7821,15463, 23105, 30747, 38389, 46031, 53673 Crotedumab_HeavyChain1 1807822, 15464, 23106, 30748, 38390, 46032, 53674 Crotedumab_HeavyChain2181 7823, 15465, 23107, 30749, 38391, 46033, 53675Crotedumab_LightChain1 182 7824, 15466, 23108, 30750, 38392, 46034,53676 Crotedumab_LightChain2 183 7825, 15467, 23109, 30751, 38393,46035, 53677 Dacetuzumab_HeavyChain1 184 7826, 15468, 23110, 30752,38394, 46036, 53678 Dacetuzumab_LightChain1 185 7827, 15469, 23111,30753, 38395, 46037, 53679 Dacliximab_LightChain_VJ-Region 186 7828,15470, 23112, 30754, 38396, 46038, 53680Dacliximab_gamma2-Chain_VDJ-Region 187 7829, 15471, 23113, 30755, 38397,46039, 53681 Daclizumab_HeavyChain 188 7830, 15472, 23114, 30756, 38398,46040, 53682 Daclizumab_LightChain 189 7831, 15473, 23115, 30757, 38399,46041, 53683 Dalotuzumab_HeavyChain1 190 7832, 15474, 23116, 30758,38400, 46042, 53684 Dalotuzumab_LightChain1 191 7833, 15475, 23117,30759, 38401, 46043, 53685 Dapirolizumab_pegol_HeavyChain1 192 7834,15476, 23118, 30760, 38402, 46044, 53686 Dapirolizumab_pegol_LightChain1193 7835, 15477, 23119, 30761, 38403, 46045, 53687Daratumumab_HeavyChain1 194 7836, 15478, 23120, 30762, 38404, 46046,53688 Daratumumab_LightChain1 195 7837, 15479, 23121, 30763, 38405,46047, 53689 Dectrekumab_HeavyChain1 196 7838, 15480, 23122, 30764,38406, 46048, 53690 Dectrekumab_LightChain1 197 7839, 15481, 23123,30765, 38407, 46049, 53691 Demcizumab_HeavyChain1 198 7840, 15482,23124, 30766, 38408, 46050, 53692 Demcizumab_LightChain1 199 7841,15483, 23125, 30767, 38409, 46051, 53693Denintuzumab_mafodotin_HeavyChain1 200 7842, 15484, 23126, 30768, 38410,46052, 53694 Denintuzumab_mafodotin_LightChain1 201 7843, 15485, 23127,30769, 38411, 46053, 53695 Denosumab_HeavyChain 202 7844, 15486, 23128,30770, 38412, 46054, 53696 Denosumab_LightChain 203 7845, 15487, 23129,30771, 38413, 46055, 53697 Depatuxizumab_HeavyChain1 204 7846, 15488,23130, 30772, 38414, 46056, 53698 Depatuxizumab_LightChain1 205 7847,15489, 23131, 30773, 38415, 46057, 53699Depatuxizumab_mafodotin_HeavyChain1 206 7848, 15490, 23132, 30774,38416, 46058, 53700 Depatuxizumab_mafodotin_LightChain1 207 7849, 15491,23133, 30775, 38417, 46059, 53701 Dinutuximab_beta_HeavyChain1 208 7850,15492, 23134, 30776, 38418, 46060, 53702 Dinutuximab_beta_LightChain1209 7851, 15493, 23135, 30777, 38419, 46061, 53703Dinutuximab_HeavyChain1 210 7852, 15494, 23136, 30778, 38420, 46062,53704 Dinutuximab_LightChain1 211 7853, 15495, 23137, 30779, 38421,46063, 53705 Dinutuximab_LightChain 212 7854, 15496, 23138, 30780,38422, 46064, 53706 Diridavumab_HeavyChain1 213 7855, 15497, 23139,30781, 38423, 46065, 53707 Diridavumab_LightChain1 214 7856, 15498,23140, 30782, 38424, 46066, 53708 Domagrozumab_HeavyChain1 215 7857,15499, 23141, 30783, 38425, 46067, 53709 Domagrozumab_HeavyChain 2167858, 15500, 23142, 30784, 38426, 46068, 53710 Domagrozumab_LightChain1217 7859, 15501, 23143, 30785, 38427, 46069, 53711 Drozituab_HeavyChain1218 7860, 15502, 23144, 30786, 38428, 46070, 53712 Drozituab_LightChain1219 7861, 15503, 23145, 30787, 38429, 46071, 53713Drozitumab_HeavyChain1 220 7862, 15504, 23146, 30788, 38430, 46072,53714 Drozitumab_LightChain1 221 7863, 15505, 23147, 30789, 38431,46073, 53715 Duligotumab_HeavyChain1 222 7864, 15506, 23148, 30790,38432, 46074, 53716 Duligotumab_LightChain1 223 7865, 15507, 23149,30791, 38433, 46075, 53717 Duligotuzumab_HeavyChain1 224 7866, 15508,23150, 30792, 38434, 46076, 53718 Duligotuzumab_LightChain1 225 7867,15509, 23151, 30793, 38435, 46077, 53719 Dupilumab_HeavyChain1 226 7868,15510, 23152, 30794, 38436, 46078, 53720 Dupilumab_LightChain1 227 7869,15511, 23153, 30795, 38437, 46079, 53721 Durvalumab_HeavyChain1 2287870, 15512, 23154, 30796, 38438, 46080, 53722 Durvalumab_LightChain1229 7871, 15513, 23155, 30797, 38439, 46081, 53723Dusigitumab_HeavyChain1 230 7872, 15514, 23156, 30798, 38440, 46082,53724 Dusigitumab_LightChain1 231 7873, 15515, 23157, 30799, 38441,46083, 53725 Ecromeximab_HeavyChain1 232 7874, 15516, 23158, 30800,38442, 46084, 53726 Ecromeximab_LightChain1 233 7875, 15517, 23159,30801, 38443, 46085, 53727 Eculizumab_HeavyChain1 234 7876, 15518,23160, 30802, 38444, 46086, 53728 Eculizumab_LightChain1 235 7877,15519, 23161, 30803, 38445, 46087, 53729 Efalizumab_HeavyChain 236 7878,15520, 23162, 30804, 38446, 46088, 53730 Efalizumab_LightChain 237 7879,15521, 23163, 30805, 38447, 46089, 53731Efungumab_SingleChain_variable_fragment 238 7880, 15522, 23164, 30806,38448, 46090, 53732 Eldelumab_HeavyChain1 239 7881, 15523, 23165, 30807,38449, 46091, 53733 Eldelumab_LightChain1 240 7882, 15524, 23166, 30808,38450, 46092, 53734 Elgemtumab_HeavyChain1 241 7883, 15525, 23167,30809, 38451, 46093, 53735 Elgemtumab_LightChain1 242 7884, 15526,23168, 30810, 38452, 46094, 53736 Elotuzumab_HeavyChain1 243 7885,15527, 23169, 30811, 38453, 46095, 53737 Elotuzumab_LightChain1 2447886, 15528, 23170, 30812, 38454, 46096, 53738 Emactuzumab_HeavyChain1245 7887, 15529, 23171, 30813, 38455, 46097, 53739Emactuzumab_LightChain1 246 7888, 15530, 23172, 30814, 38456, 46098,53740 Emibetuzumab_HeavyChain1 247 7889, 15531, 23173, 30815, 38457,46099, 53741 Emibetuzumab_LightChain1 248 7890, 15532, 23174, 30816,38458, 46100, 53742 Emicizumab_HeavyChain1 249 7891, 15533, 23175,30817, 38459, 46101, 53743 Emicizumab_HeavyChain2 250 7892, 15534,23176, 30818, 38460, 46102, 53744 Emicizumab_LightChain1 251 7893,15535, 23177, 30819, 38461, 46103, 53745 Enavatuzumab_HeavyChain1 2527894, 15536, 23178, 30820, 38462, 46104, 53746 Enavatuzumab_LightChain1253 7895, 15537, 23179, 30821, 38463, 46105, 53747 Enfortumab_HeavyChain254 7896, 15538, 23180, 30822, 38464, 46106, 53748 Enfortumab_LightChain255 7897, 15539, 23181, 30823, 38465, 46107, 53749Enfortumab_vedotin_HeavyChain1 256 7898, 15540, 23182, 30824, 38466,46108, 53750 Enfortumab_vedotin_LightChain1 257 7899, 15541, 23183,30825, 38467, 46109, 53751 Enoblituzumab_HeavyChain 258 7900, 15542,23184, 30826, 38468, 46110, 53752 Enoblituzumab_LightChain 259 7901,15543, 23185, 30827, 38469, 46111, 53753 Enokizumab_HeavyChain1 2607902, 15544, 23186, 30828, 38470, 46112, 53754 Enokizumab_LightChain1261 7903, 15545, 23187, 30829, 38471, 46113, 53755 Enokizumab_LightChain262 7904, 15546, 23188, 30830, 38472, 46114, 53756Enoticumab_HeavyChain1 263 7905, 15547, 23189, 30831, 38473, 46115,53757 Enoticumab_LightChain1 264 7906, 15548, 23190, 30832, 38474,46116, 53758 Ensituximab_HeavyChain1 265 7907, 15549, 23191, 30833,38475, 46117, 53759 Ensituximab_LightChain1 266 7908, 15550, 23192,30834, 38476, 46118, 53760 Ensituximab_SingleChain_variable_fragment 2677909, 15551, 23193, 30835, 38477, 46119, 53761 Entolimod_Chain1 2687910, 15552, 23194, 30836, 38478, 46120, 53762 Epratuzumab_HeavyChain269 7911, 15553, 23195, 30837, 38479, 46121, 53763Epratuzumab_LightChain 270 7912, 15554, 23196, 30838, 38480, 46122,53764 Eptacog_beta_HeavyChain1 271 7913, 15555, 23197, 30839, 38481,46123, 53765 Eptacog_beta_LightChain1 272 7914, 15556, 23198, 30840,38482, 46124, 53766 Erlizuab_HeavyChain1 273 7915, 15557, 23199, 30841,38483, 46125, 53767 Erlizuab_LightChain1 274 7916, 15558, 23200, 30842,38484, 46126, 53768 Etaracizumab_HeavyChain1 275 7917, 15559, 23201,30843, 38485, 46127, 53769 Etaracizumab_LightChain1 276 7918, 15560,23202, 30844, 38486, 46128, 53770 Etrolizumab_HeavyChain1 277 7919,15561, 23203, 30845, 38487, 46129, 53771 Etrolizumab_HeavyChain2 2787920, 15562, 23204, 30846, 38488, 46130, 53772 Etrolizuab_LightChain1279 7921, 15563, 23205, 30847, 38489, 46131, 53773Etrolizumab_HeavyChain1 280 7922, 15564, 23206, 30848, 38490, 46132,53774 Etrolizumab_LightChain1 281 7923, 15565, 23207, 30849, 38491,46133, 53775 Evinacumab_HeavyChain1 282 7924, 15566, 23208, 30850,38492, 46134, 53776 Evinacumab_LightChain1 283 7925, 15567, 23209,30851, 38493, 46135, 53777 Evolocumab_HeavyChain1 284 7926, 15568,23210, 30852, 38494, 46136, 53778 Evolocumab_LightChain1 285 7927,15569, 23211, 30853, 38495, 46137, 53779 Exbivirumab_HeavyChain1 2867928, 15570, 23212, 30854, 38496, 46138, 53780 Exbivirumab_LightChain1287 7929, 15571, 23213, 30855, 38497, 46139, 53781Farletuzumab_HeavyChain1 288 7930, 15572, 23214, 30856, 38498, 46140,53782 Farletuzumab_LightChain1 289 7931, 15573, 23215, 30857, 38499,46141, 53783 Fasinumab_HeavyChain1 290 7932, 15574, 23216, 30858, 38500,46142, 53784 Fasinumab_LightChain1 291 7933, 15575, 23217, 30859, 38501,46143, 53785 Fezakinumab_HeavyChain1 292 7934, 15576, 23218, 30860,38502, 46144, 53786 Fezakinumab_LightChain1 293 7935, 15577, 23219,30861, 38503, 46145, 53787 FG-3019_HeavyChain1 294 7936, 15578, 23220,30862, 38504, 46146, 53788 FG-3019_LightChain1 295 7937, 15579, 23221,30863, 38505, 46147, 53789 Fibatuzumab_HeavyChain1 296 7938, 15580,23222, 30864, 38506, 46148, 53790 Fibatuzumab_LightChain1 297 7939,15581, 23223, 30865, 38507, 46149, 53791 Ficlatuzumab_HeavyChain1 2987940, 15582, 23224, 30866, 38508, 46150, 53792 Ficlatuzumab_HeavyChain299 7941, 15583, 23225, 30867, 38509, 46151, 53793Ficlatuzumab_LightChain1 300 7942, 15584, 23226, 30868, 38510, 46152,53794 Figitumumab_HeavyChain1 301 7943, 15585, 23227, 30869, 38511,46153, 53795 Figitumumab_LightChain1 302 7944, 15586, 23228, 30870,38512, 46154, 53796 Firivumab_HeavyChain1 303 7945, 15587, 23229, 30871,38513, 46155, 53797 Firivumab_LightChain1 304 7946, 15588, 23230, 30872,38514, 46156, 53798 Flanvotumab_HeavyChain1 305 7947, 15589, 23231,30873, 38515, 46157, 53799 Flanvotumab_LightChain1 306 7948, 15590,23232, 30874, 38516, 46158, 53800 Fletikumab_HeavyChain1 307 7949,15591, 23233, 30875, 38517, 46159, 53801 Fletikumab_LightChain1 3087950, 15592, 23234, 30876, 38518, 46160, 53802 Fontolizumab_HeavyChain1309 7951, 15593, 23235, 30877, 38519, 46161, 53803Fontolizumab_LightChain1 310 7952, 15594, 23236, 30878, 38520, 46162,53804 Foralumab_HeavyChain1 311 7953, 15595, 23237, 30879, 38521, 46163,53805 Foralumab_LightChain1 312 7954, 15596, 23238, 30880, 38522, 46164,53806 Foravirumab_HeavyChain1 313 7955, 15597, 23239, 30881, 38523,46165, 53807 Foravirumab_HeavyChain 314 7956, 15598, 23240, 30882,38524, 46166, 53808 Foravirumab_LightChain1 315 7957, 15599, 23241,30883, 38525, 46167, 53809 Fresolimumab_HeavyChain1 316 7958, 15600,23242, 30884, 38526, 46168, 53810 Fresolimumab_LightChain1 317 7959,15601, 23243, 30885, 38527, 46169, 53811 Fulranumab_HeavyChain1 3187960, 15602, 23244, 30886, 38528, 46170, 53812 Fulranumab_LightChain1319 7961, 15603, 23245, 30887, 38529, 46171, 53813 Futuximab_HeavyChain1320 7962, 15604, 23246, 30888, 38530, 46172, 53814 Futuximab_LightChain1321 7963, 15605, 23247, 30889, 38531, 46173, 53815Galcanezumab_HeavyChain1 322 7964, 15606, 23248, 30890, 38532, 46174,53816 Galcanezumab_LightChain1 323 7965, 15607, 23249, 30891, 38533,46175, 53817 Galiximab_HeavyChain1 324 7966, 15608, 23250, 30892, 38534,46176, 53818 Galiximab_LightChain1 325 7967, 15609, 23251, 30893, 38535,46177, 53819 Ganitumab_HeavyChain1 326 7968, 15610, 23252, 30894, 38536,46178, 53820 Ganitumab_LightChain1 327 7969, 15611, 23253, 30895, 38537,46179, 53821 Gantenerumab_HeavyChain1 328 7970, 15612, 23254, 30896,38538, 46180, 53822 Gantenerumab_LightChain1 329 7971, 15613, 23255,30897, 38539, 46181, 53823 Gemtuzumab_HeavyChain1 330 7972, 15614,23256, 30898, 38540, 46182, 53824 Gemtuzumab_HeavyChain2 331 7973,15615, 23257, 30899, 38541, 46183, 53825 Gemtuzumab_LightChain2 3327974, 15616, 23258, 30900, 38542, 46184, 53826Gemtuzumab_ozogamicin_LightChain1 333 7975, 15617, 23259, 30901, 38543,46185, 53827 Gevokizumab_HeavyChain1 334 7976, 15618, 23260, 30902,38544, 46186, 53828 Gevokizumab_LightChain1 335 7977, 15619, 23261,30903, 38545, 46187, 53829 Girentuximab_HeavyChain1 336 7978, 15620,23262, 30904, 38546, 46188, 53830 Girentuximab_LightChain1 337 7979,15621, 23263, 30905, 38547, 46189, 53831 Glembatumumab_HeavyChain1 3387980, 15622, 23264, 30906, 38548, 46190, 53832 Glembatumumab_LightChain1339 7981, 15623, 23265, 30907, 38549, 46191, 53833 Goilixiab_HeavyChain1340 7982, 15624, 23266, 30908, 38550, 46192, 53834 Goilixiab_LightChain1341 7983, 15625, 23267, 30909, 38551, 46193, 53835Guselkumab_HeavyChain1 342 7984, 15626, 23268, 30910, 38552, 46194,53836 Guselkumab_LightChain1 343 7985, 15627, 23269, 30911, 38553,46195, 53837 HuMab-001_HeavyChain_VDJ-Region 344 7986, 15628, 23270,30912, 38554, 46196, 53838 HuMab-001_LightChain_VJ-Region 345 7987,15629, 23271, 30913, 38555, 46197, 53839HuMab-005_HeavyChain_gamma-Chain_VDJ-Region 346 7988, 15630, 23272,30914, 38556, 46198, 53840 HuMab-005_LightChain_VJ-Region 347 7989,15631, 23273, 30915, 38557, 46199, 53841 HuMab-006_HeavyChain_VDJ-Region348 7990, 15632, 23274, 30916, 38558, 46200, 53842HuMab-006_LightChain_VJ-Region 349 7991, 15633, 23275, 30917, 38559,46201, 53843 HuMab-019_HeavyChain_VDJ-Region 350 7992, 15634, 23276,30918, 38560, 46202, 53844 HuMab-021_HeavyChain_VDJ-Region 351 7993,15635, 23277, 30919, 38561, 46203, 53845 HuMab-021_LightChain_VJ-Region352 7994, 15636, 23278, 30920, 38562, 46204, 53846HuMab-025_HeavyChain_VDJ-Region 353 7995, 15637, 23279, 30921, 38563,46205, 53847 HuMab-025_LightChain_VJ-Region 354 7996, 15638, 23280,30922, 38564, 46206, 53848 HuMab-027_HeavyChain_VDJ-Region 355 7997,15639, 23281, 30923, 38565, 46207, 53849 HuMab-032_HeavyChain_VDJ-Region356 7998, 15640, 23282, 30924, 38566, 46208, 53850HuMab-032_LightChain_VJ-Region 357 7999, 15641, 23283, 30925, 38567,46209, 53851 HuMab-033_HeavyChain_VDJ-Region 358 8000, 15642, 23284,30926, 38568, 46210, 53852 HuMab-035_HeavyChain_VDJ-Region 359 8001,15643, 23285, 30927, 38569, 46211, 53853 HuMab-036_HeavyChain_VDJ-Region360 8002, 15644, 23286, 30928, 38570, 46212, 53854HuMab-036_LightChain_VJ-Region 361 8003, 15645, 23287, 30929, 38571,46213, 53855 HuMab-041_HeavyChain_VDJ-Region 362 8004, 15646, 23288,30930, 38572, 46214, 53856 HuMab-044_HeavyChain_VDJ-Region 363 8005,15647, 23289, 30931, 38573, 46215, 53857 HuMab-049_HeavyChain_VDJ-Region364 8006, 15648, 23290, 30932, 38574, 46216, 53858HuMab-049_LightChain_VJ-Region 365 8007, 15649, 23291, 30933, 38575,46217, 53859 HuMab-050_HeavyChain_VDJ-Region 366 8008, 15650, 23292,30934, 38576, 46218, 53860 HuMab-050_LightChain_VJ-Region 367 8009,15651, 23293, 30935, 38577, 46219, 53861 HuMab-054_HeavyChain_VDJ-Region368 8010, 15652, 23294, 30936, 38578, 46220, 53862HuMab-054_LightChain_VJ-Region 369 8011, 15653, 23295, 30937, 38579,46221, 53863 HuMab-055_HeavyChain_VDJ-Region 370 8012, 15654, 23296,30938, 38580, 46222, 53864 HuMab-059_HeavyChain_VDJ-Region 371 8013,15655, 23297, 30939, 38581, 46223, 53865 HuMab-059_LightChain_VJ-Region372 8014, 15656, 23298, 30940, 38582, 46224, 53866HuMab-060_HeavyChain_VDJ-Region 373 8015, 15657, 23299, 30941, 38583,46225, 53867 HuMab-060_LightChain_VJ-Region 374 8016, 15658, 23300,30942, 38584, 46226, 53868 HuMab-067_HeavyChain_VDJ-Region 375 8017,15659, 23301, 30943, 38585, 46227, 53869 HuMab-072_HeavyChain_VDJ-Region376 8018, 15660, 23302, 30944, 38586, 46228, 53870HuMab-072_LightChain_VJ-Region 377 8019, 15661, 23303, 30945, 38587,46229, 53871 HuMab-084_HeavyChain_VDJ-Region 378 8020, 15662, 23304,30946, 38588, 46230, 53872 HuMab-084_LightChain_VJ-Region 379 8021,15663, 23305, 30947, 38589, 46231, 53873 HuMab-091_HeavyChain_VDJ-Region380 8022, 15664, 23306, 30948, 38590, 46232, 53874HuMab-091_LightChain_VJ-Region 381 8023, 15665, 23307, 30949, 38591,46233, 53875 HuMab-093_HeavyChain_VDJ-Region 382 8024, 15666, 23308,30950, 38592, 46234, 53876 HuMab-098_HeavyChain_VDJ-Region 383 8025,15667, 23309, 30951, 38593, 46235, 53877 HuMab-098_LightChain_VJ-Region384 8026, 15668, 23310, 30952, 38594, 46236, 53878HuMab-100_HeavyChain_VDJ-Region 385 8027, 15669, 23311, 30953, 38595,46237, 53879 HuMab-106_HeavyChain_VDJ-Region 386 8028, 15670, 23312,30954, 38596, 46238, 53880 HuMab-106_LightChain_VJ-Region 387 8029,15671, 23313, 30955, 38597, 46239, 53881 HuMab_10F8_HeavyChain_V-Region388 8030, 15672, 23314, 30956, 38598, 46240, 53882HuMab_10F8_HeavyChain_V-Region_Precursor 389 8031, 15673, 23315, 30957,38599, 46241, 53883 HuMab_10F8_LightChain_V-Region 390 8032, 15674,23316, 30958, 38600, 46242, 53884HuMab_10F8_LightChain_V-Region_Precursor 391 8033, 15675, 23317, 30959,38601, 46243, 53885 HuMab-111_HeavyChain_VDJ-Region 392 8034, 15676,23318, 30960, 38602, 46244, 53886 HuMab-111_LightChain_VJ-Region 3938035, 15677, 23319, 30961, 38603, 46245, 53887HuMab-123_HeavyChain_VDJ-Region 394 8036, 15678, 23320, 30962, 38604,46246, 53888 HuMab-123_LightChain_VJ-Region 395 8037, 15679, 23321,30963, 38605, 46247, 53889 HuMab-124_HeavyChain_VDJ-Region 396 8038,15680, 23322, 30964, 38606, 46248, 53890 HuMab-125_HeavyChain_VDJ-Region397 8039, 15681, 23323, 30965, 38607, 46249, 53891HuMab-125_LightChain_VJ-Region 398 8040, 15682, 23324, 30966, 38608,46250, 53892 HuMab-127_HeavyChain_VDJ-Region 399 8041, 15683, 23325,30967, 38609, 46251, 53893 HuMab-127_LightChain_VJ-Region 400 8042,15684, 23326, 30968, 38610, 46252, 53894 HuMab-129_HeavyChain_VDJ-Region401 8043, 15685, 23327, 30969, 38611, 46253, 53895HuMab-129_LightChain_VJ-Region 402 8044, 15686, 23328, 30970, 38612,46254, 53896 HuMab-132_HeavyChain_VDJ-Region 403 8045, 15687, 23329,30971, 38613, 46255, 53897 HuMab-132_LightChain_VJ-Region 404 8046,15688, 23330, 30972, 38614, 46256, 53898 HuMab-143_HeavyChain_VDJ-Region405 8047, 15689, 23331, 30973, 38615, 46257, 53899HuMab-143_LightChain_VJ-Region 406 8048, 15690, 23332, 30974, 38616,46258, 53900 HuMab-150_HeavyChain_VDJ-Region 407 8049, 15691, 23333,30975, 38617, 46259, 53901 HuMab-150_LightChain_VJ-Region 408 8050,15692, 23334, 30976, 38618, 46260, 53902 HuMab-152_HeavyChain_VDJ-Region409 8051, 15693, 23335, 30977, 38619, 46261, 53903HuMab-152_LightChain_VJ-Region 410 8052, 15694, 23336, 30978, 38620,46262, 53904 HuMab-153_HeavyChain_VDJ-Region 411 8053, 15695, 23337,30979, 38621, 46263, 53905 HuMab-153_LightChain_VJ-Region 412 8054,15696, 23338, 30980, 38622, 46264, 53906 HuMab-159_HeavyChain_VDJ-Region413 8055, 15697, 23339, 30981, 38623, 46265, 53907HuMab-159_LightChain_VJ-Region 414 8056, 15698, 23340, 30982, 38624,46266, 53908 HuMab-160_HeavyChain_VDJ-Region 415 8057, 15699, 23341,30983, 38625, 46267, 53909 HuMab-160_LightChain_VJ-Region 416 8058,15700, 23342, 30984, 38626, 46268, 53910 HuMab-162_HeavyChain_VDJ-Region417 8059, 15701, 23343, 30985, 38627, 46269, 53911HuMab-162_LightChain_VJ-Region 418 8060, 15702, 23344, 30986, 38628,46270, 53912 HuMab-163_HeavyChain_VDJ-Region 419 8061, 15703, 23345,30987, 38629, 46271, 53913 HuMab-163_LightChain_VJ-Region 420 8062,15704, 23346, 30988, 38630, 46272, 53914 HuMab-166_HeavyChain_VDJ-Region421 8063, 15705, 23347, 30989, 38631, 46273, 53915HuMab-166_LightChain_VJ-Region 422 8064, 15706, 23348, 30990, 38632,46274, 53916 HuMab-167_HeavyChain_VDJ-Region 423 8065, 15707, 23349,30991, 38633, 46275, 53917 HuMab-169_HeavyChain_VDJ-Region 424 8066,15708, 23350, 30992, 38634, 46276, 53918 HuMab-169_LightChain_VJ-Region425 8067, 15709, 23351, 30993, 38635, 46277, 53919HuMab-708_HeavyChain_VH-Region 426 8068, 15710, 23352, 30994, 38636,46278, 53920 HuMab-708_HeavyChain_V-Region 427 8069, 15711, 23353,30995, 38637, 46279, 53921 HuMab-708_LightChain_VL-Region 428 8070,15712, 23354, 30996, 38638, 46280, 53922 HuMab-708_LightChain_V-Region429 8071, 15713, 23355, 30997, 38639, 46281, 53923huMAb-anti-MSP10.1_LightChain_VJ-Region 430 8072, 15714, 23356, 30998,38640, 46282, 53924 huMAb-anti-MSP10.2_LightChain_VJ-Region 431 8073,15715, 23357, 30999, 38641, 46283, 53925 HUMAB-Clone_18_VJ-Region 4328074, 15716, 23358, 31000, 38642, 46284, 53926 HUMAB-Clone_22_VJ-Region433 8075, 15717, 23359, 31001, 38643, 46285, 53927HuMab-L612_μChain_VDJ-Region_Precursor 434 8076, 15718, 23360, 31002,38644, 46286, 53928 HuMab_LC5002-002_LightChain_V-Region 435 8077,15719, 23361, 31003, 38645, 46287, 53929HuMab_LC5002-002_gamma1-Chain_V-Region 436 8078, 15720, 23362, 31004,38646, 46288, 53930 HuMab_LC5002-003_LightChain_V-Region 437 8079,15721, 23363, 31005, 38647, 46289, 53931HuMab_LC5002-003_gamma1-Chain_V-Region 438 8080, 15722, 23364, 31006,38648, 46290, 53932 HuMab_LC5002-005_LightChain_V-Region 439 8081,15723, 23365, 31007, 38649, 46291, 53933HuMab_LC5002-005_gamma1-Chain_V-Region 440 8082, 15724, 23366, 31008,38650, 46292, 53934 HuMab_LC5002-007_LightChain_V-Region 441 8083,15725, 23367, 31009, 38651, 46293, 53935HuMab_LC5002-007_gamma1-Chain_V-Region 442 8084, 15726, 23368, 31010,38652, 46294, 53936 HuMab_LC5002-018_gamma1-Chain_V-Region 443 8085,15727, 23369, 31011, 38653, 46295, 53937 Ibalizumab_HeavyChain1 4448086, 15728, 23370, 31012, 38654, 46296, 53938 Ibalizumab_LightChain1445 8087, 15729, 23371, 31013, 38655, 46297, 53939Ibritumomab_tiuxetan_HeavyChain 446 8088, 15730, 23372, 31014, 38656,46298, 53940 Ibritumomab_tiuxetan_LightChain 447 8089, 15731, 23373,31015, 38657, 46299, 53941 Icrucumab_HeavyChain1 448 8090, 15732, 23374,31016, 38658, 46300, 53942 Icrucumab_LightChain1 449 8091, 15733, 23375,31017, 38659, 46301, 53943 Idarucizumab_HeavyChain1 450 8092, 15734,23376, 31018, 38660, 46302, 53944 Idarucizumab_LightChain1 451 8093,15735, 23377, 31019, 38661, 46303, 53945 Igatuzuab_HeavyChain1 452 8094,15736, 23378, 31020, 38662, 46304, 53946 Igatuzuab_LightChain1 453 8095,15737, 23379, 31021, 38663, 46305, 53947 IGF-IR_HUMAB-1A_HeavyChain 4548096, 15738, 23380, 31022, 38664, 46306, 53948IGF-IR_HUMAB-23_HeavyChain 455 8097, 15739, 23381, 31023, 38665, 46307,53949 IGF-IR_HUMAB-23_LightChain 456 8098, 15740, 23382, 31024, 38666,46308, 53950 IGF-IR_HUMAB-8_HeavyChain 457 8099, 15741, 23383, 31025,38667, 46309, 53951 IGF-IR_HUMAB-8_LightChain 458 8100, 15742, 23384,31026, 38668, 46310, 53952 ImAb1_LightChain 459 8101, 15743, 23385,31027, 38669, 46311, 53953 ImAb1_gamma1-Chain 460 8102, 15744, 23386,31028, 38670, 46312, 53954 Imalumab_HeavyChain1 461 8103, 15745, 23387,31029, 38671, 46313, 53955 Imalumab_LightChain1 462 8104, 15746, 23388,31030, 38672, 46314, 53956 Imgatuzumab_HeavyChain1 463 8105, 15747,23389, 31031, 38673, 46315, 53957 Imgatuzumab_LightChain1 464 8106,15748, 23390, 31032, 38674, 46316, 53958 Inclacumab_HeavyChain1 4658107, 15749, 23391, 31033, 38675, 46317, 53959 Inclacumab_LightChain1466 8108, 15750, 23392, 31034, 38676, 46318, 53960Indatuximab_ravtansine_HeavyChain1 467 8109, 15751, 23393, 31035, 38677,46319, 53961 Indatuximab_ravtansine_LightChain1 468 8110, 15752, 23394,31036, 38678, 46320, 53962 Indusatumab_vedotin_HeavyChain1 469 8111,15753, 23395, 31037, 38679, 46321, 53963 Indusatumab_vedotin_LightChain1470 8112, 15754, 23396, 31038, 38680, 46322, 53964Inebilizumab_HeavyChain1 471 8113, 15755, 23397, 31039, 38681, 46323,53965 Inebilizumab_LightChain1 472 8114, 15756, 23398, 31040, 38682,46324, 53966 Insulin_peglispro_Fragment1 473 8115, 15757, 23399, 31041,38683, 46325, 53967 Insulin_peglispro_Fragment2 474 8116, 15758, 23400,31042, 38684, 46326, 53968 Interferon_beta-1b_chain1 475 8117, 15759,23401, 31043, 38685, 46327, 53969 Intetumumab_HeavyChain1 476 8118,15760, 23402, 31044, 38686, 46328, 53970 Intetumumab_LightChain1 4778119, 15761, 23403, 31045, 38687, 46329, 53971Iodine_(1241)_Girentuximab_HeavyChain1 478 8120, 15762, 23404, 31046,38688, 46330, 53972 Iodine_(1241)_Girentuximab_LightChain1 479 8121,15763, 23405, 31047, 38689, 46331, 53973Iodine_(1311)_Derlotuxiab_biotin_HeavyChain1 480 8122, 15764, 23406,31048, 38690, 46332, 53974 Iodine_(1311)_Derlotuxiab_biotin_LightChain1481 8123, 15765, 23407, 31049, 38691, 46333, 53975Iodine_(1311)_Derlotuximab_biotin_HeavyChain1 482 8124, 15766, 23408,31050, 38692, 46334, 53976 Iodine_(1311)_Derlotuximab_biotin_LightChain1483 8125, 15767, 23409, 31051, 38693, 46335, 53977 Ipilimumab_HeavyChain484 8126, 15768, 23410, 31052, 38694, 46336, 53978 Ipilimumab_LightChain485 8127, 15769, 23411, 31053, 38695, 46337, 53979Iratumumab_HeavyChain1 486 8128, 15770, 23412, 31054, 38696, 46338,53980 Iratumumab_LightChain1 487 8129, 15771, 23413, 31055, 38697,46339, 53981 Isatuximab_HeavyChain1 488 8130, 15772, 23414, 31056,38698, 46340, 53982 Isatuximab_LightChain1 489 8131, 15773, 23415,31057, 38699, 46341, 53983 Itolizumab_HeavyChain1 490 8132, 15774,23416, 31058, 38700, 46342, 53984 Itolizumab_LightChain1 491 8133,15775, 23417, 31059, 38701, 46343, 53985 Ixekizumab_HeavyChain1 4928134, 15776, 23418, 31060, 38702, 46344, 53986 Ixekizumab_LightChain1493 8135, 15777, 23419, 31061, 38703, 46345, 53987Labetuzumab_govitecan_HeavyChain1 494 8136, 15778, 23420, 31062, 38704,46346, 53988 Labetuzumab_govitecan_LightChain1 495 8137, 15779, 23421,31063, 38705, 46347, 53989 Lambrolizumab_HeavyChain1 496 8138, 15780,23422, 31064, 38706, 46348, 53990 Lambrolizumab_LightChain1 497 8139,15781, 23423, 31065, 38707, 46349, 53991 Lampalizumab_HeavyChain1 4988140, 15782, 23424, 31066, 38708, 46350, 53992 Lampalizumab_LightChain1499 8141, 15783, 23425, 31067, 38709, 46351, 53993Lanadelumab_HeavyChain1 500 8142, 15784, 23426, 31068, 38710, 46352,53994 Lanadelumab_LightChain1 501 8143, 15785, 23427, 31069, 38711,46353, 53995 Landogrozumab_HeavyChain1 502 8144, 15786, 23428, 31070,38712, 46354, 53996 Landogrozumab_LightChain1 503 8145, 15787, 23429,31071, 38713, 46355, 53997 Laprituximab_emtansine_HeavyChain1 504 8146,15788, 23430, 31072, 38714, 46355, 53998Laprituximab_emtansine_LightChain1 505 8147, 15789, 23431, 31073, 38715,46357, 53999 Lealesoab_HeavyChain1 506 8148, 15790, 23432, 31074, 38716,46358, 54000 Lealesoab_LightChain1 507 8149, 15791, 23433, 31075, 38717,46359, 54001 Lebrikizumab_HeavyChain1 508 8150, 15792, 23434, 31076,38718, 46360, 54002 Lebrikizumab_LightChain1 509 8151, 15793, 23435,31077, 38719, 46361, 54003 Lenercept_chain1 510 8152, 15794, 23436,31078, 38720, 46362, 54004 Lenzilumab_HeavyChain1 511 8153, 15795,23437, 31079, 38721, 46363, 54005 Lenzilumab_LightChain1 512 8154,15796, 23438, 31080, 38722, 46364, 54006 Lerdelimumab_HeavyChain1 5138155, 15797, 23439, 31081, 38723, 46365, 54007 Lerdelimumab_LightChain1514 8156, 15798, 23440, 31082, 38724, 46366, 54008Lexatumumab_HeavyChain1 515 8157, 15799, 23441, 31083, 38725, 46367,54009 Lexatumumab_HeavyChain 516 8158, 15800, 23442, 31084, 38726,46368, 54010 Lexatumumab_LightChain1 517 8159, 15801, 23443, 31085,38727, 46369, 54011 Lexatumumab_LightChain 518 8160, 15802, 23444,31086, 38728, 46370, 54012 Libivirumab_HeavyChain1 519 8161, 15803,23445, 31087, 38729, 46371, 54013 Libivirumab_LightChain1 520 8162,15804, 23446, 31088, 38730, 46372, 54014 Lifastuzumab_HeavyChain 5218163, 15805, 23447, 31089, 38731, 46373, 54015 Lifastuzumab_LightChain522 8164, 15806, 23448, 31090, 38732, 46374, 54016Lifastuzumab_vedotin_HeavyChain1 523 8165, 15807, 23449, 31091, 38733,46375, 54017 Lifastuzumab_vedotin_LightChain1 524 8166, 15808, 23450,31092, 38734, 46376, 54018 Ligelizumab_HeavyChain1 525 8167, 15809,23451, 31093, 38735, 46377, 54019 Ligelizumab_LightChain1 526 8168,15810, 23452, 31094, 38736, 46378, 54020 Lilotomab_HeavyChain1 527 8169,15811, 23453, 31095, 38737, 46379, 54021 Lilotomab_LightChain1 528 8170,15812, 23454, 31096, 38738, 46380, 54022 Lintuzumab_HeavyChain1 5298171, 15813, 23455, 31097, 38739, 46381, 54023 Lintuzumab_LightChain1530 8172, 15814, 23456, 31098, 38740, 46382, 54024 Lirilumab_HeavyChain1531 8173, 15815, 23457, 31099, 38741, 46383, 54025 Lirilumab_LightChain1532 8174, 15816, 23458, 31100, 38742, 46384, 54026Lodelcizumab_HeavyChain1 533 8175, 15817, 23459, 31101, 38743, 46385,54027 Lodelcizumab_LightChain1 534 8176, 15818, 23460, 31102, 38744,46386, 54028 Lokivetmab_HeavyChain1 535 8177, 15819, 23461, 31103,38745, 46387, 54029 Lokivetmab_LightChain1 536 8178, 15820, 23462,31104, 38746, 46388, 54030 Lorvotuzumab_mertansine_HeavyChain1 537 8179,15821, 23463, 31105, 38747, 46389, 54031Lorvotuzumab_mertansine_LightChain1 538 8180, 15822, 23464, 31106,38748, 46390, 54032 Lpathomab_VL 539 8181, 15823, 23465, 31107, 38749,46391, 54033 Lpathomab_gamma1-Chain_VDJ-Region 540 8182, 15824, 23466,31108, 38750, 46392, 54034 Lucatumumab_HeavyChain1 541 8183, 15825,23467, 31109, 38751, 46393, 54035 Lucatumumab_LightChain1 542 8184,15826, 23468, 31110, 38752, 46394, 54036 Lulizumab_pegol_LightChain1 5438185, 15827, 23469, 31111, 38753, 46395, 54037Lulizumab_pegol_LightChain 544 8186, 15828, 23470, 31112, 38754, 46396,54038 Lumiliximab_HeavyChain1 545 8187, 15829, 23471, 31113, 38755,46397, 54039 Lumiliximab_LightChain1 546 8188, 15830, 23472, 31114,38756, 46398, 54040 Lumretuzumab_HeavyChain1 547 8189, 15831, 23473,31115, 38757, 46399, 54041 Lumretuzumab_LightChain1 548 8190, 15832,23474, 31116, 38758, 46400, 54042Lutetium_(177Lu)_lilotomab_satetraxetan_HeavyChain1 549 8191, 15833,23475, 31117, 38759, 46401, 54043Lutetium_(177Lu)_lilotomab_satetraxetan_LightChain1 550 8192, 15834,23476, 31118, 38760, 46402, 54044 Margetuximab_HeavyChain1 551 8193,15835, 23477, 31119, 38761, 46403, 54045 Margetuximab_LightChain1 5528194, 15836, 23478, 31120, 38762, 46404, 54046Marzeptacog_alfa_HeavyChain1 553 8195, 15837, 23479, 31121, 38763,46405, 54047 Marzeptacog_alfa_LightChain1 554 8196, 15838, 23480, 31122,38764, 46406, 54048 Matuzumab_HeavyChain1_variant_3c08_H 555 8197,15839, 23481, 31123, 38765, 46407, 54049Matuzumab_HeavyChain1_variant_3c09_C 556 8198, 15840, 23482, 31124,38766, 46408, 54050 Matuzumab_LightChain1_variant_3c08_L 557 8199,15841, 23483, 31125, 38767, 46409, 54051Matuzumab_LightChain1_variant_3c09_B 558 8200, 15842, 23484, 31126,38768, 46410, 54052 Mavrilimumab_HeavyChain1 559 8201, 15843, 23485,31127, 38769, 46411, 54053 Mavrilimumab_LightChain1 560 8202, 15844,23486, 31128, 38770, 49412, 54054 MDX-1303_HeavyChain1 561 8203, 15845,23487, 31129, 38771, 46413, 54055 MDX-1303_LightChain1 562 8204, 15846,23488, 31130, 38772, 46414, 54056 Mepolizumab_HeavyChain1 563 8205,15847, 23489, 31131, 38773, 46415, 54057 Mepolizumab_LightChain1 5648206, 15848, 23490, 31132, 38774, 46416, 54058 Metelimumab_HeavyChain1565 8207, 15849, 23491, 31133, 38775, 46417, 54059Metelimumab_LightChain1 566 8208, 15850, 23492, 31134, 38776, 46418,54060 Milatuzumab_HeavyChain1 567 8209, 15851, 23493, 31135, 38777,46419, 54061 Milatuzumab_LightChain1 568 8210, 15852, 23494, 31136,38778, 46420, 54062 Mirvetuximab_HeavyChain1 569 8211, 15853, 23495,31137, 38779, 46421, 54063 Mirvetuximab_LightChain1 570 8212, 15854,23496, 31138, 38780, 46422, 54064 Modotuximab_HeavyChain1 571 8213,15855, 23497, 31139, 38781, 46423, 54065 Modotuximab_LightChain1 5728214, 15856, 23498, 31140, 38782, 46424, 54066 Mogamulizumab_HeavyChain1573 8215, 15857, 23499, 31141, 38783, 46425, 54067Mogamulizumab_LightChain1 574 8216, 15858, 23500, 31142, 38784, 46426,54068 Monalizumab_HeavyChain1 575 8217, 15859, 23501, 31143, 38785,46427, 54069 Monalizumab_LightChain1 576 8218, 15860, 23502, 31144,38786, 46428, 54070 Motavizumab_HeavyChain 577 8219, 15861, 23503,31145, 38787, 46429, 54071 Motavizumab_HeavyChain_variant 578 8220,15862, 23504, 31146, 38788, 46430, 54072 Motavizumab_LightChain 5798221, 15863, 23505, 31147, 38789, 46431, 54073Motavizumab_LightChain_variant 580 8222, 15864, 23506, 31148, 38790,46432, 54074 Moxetumomab_pasudotox_HeavyChain1 581 8223, 15865, 23507,31149, 38791, 46433, 54075 Moxetumomab_pasudotox_LightChain1 582 8224,15866, 23508, 31150, 38792, 46434, 54076 Muromonab-CD3_HeavyChain 5838225, 15867, 23509, 31151, 38793, 46435, 54077 Muromonab-CD3_LightChain584 8226, 15868, 23510, 31152, 38794, 46436, 54078 Namilumab_HeavyChain1585 8227, 15869, 23511, 31153, 38795, 46437, 54079 Namilumab_LightChain1586 8228, 15870, 23512, 31154, 38796, 46438, 54080Naptumomab_estafenatox_HeavyChain 587 8229, 15871, 23513, 31155, 38797,46439, 54081 Naptumomab_estafenatox_LightChain 588 8230, 15872, 23514,31156, 38798, 46440, 54082 Narnatumab_HeavyChain1 589 8231, 15873,23515, 31157, 38799, 46441, 54083 Narnatumab_LightChain1 590 8232,15874, 23516, 31158, 38800, 46442, 54084 Natalizumab_HeavyChain1 5918233, 15875, 23517, 31159, 38801, 46443, 54085 Natalizumab_LightChain1592 8234, 15876, 23518, 31160, 38802, 46444, 54086Navicixizumab_HeavyChain1 593 8235, 15877, 23519, 31161, 38803, 46445,54087 Navicixizumab_HeavyChain2 594 8236, 15878, 23520, 31162, 38804,46446, 54088 Navicixizumab_LightChain1 595 8237, 15879, 23521, 31163,38805, 46447, 54089 Navivumab_HeavyChain1 596 8238, 15880, 23522, 31164,38806, 46448, 54090 Navivumab_LightChain1 597 8239, 15881, 23523, 31165,38807, 46449, 54091 Ndimab-varB_HeavyChain 598 8240, 15882, 23524,31166, 38808, 46450, 54092 Ndimab-varB_LightChain 599 8241, 15883,23525, 31167, 38809, 46451, 54093 Necitumumab_HeavyChain1 600 8242,15884, 23526, 31168, 38810, 46452, 54094 Necitumumab_LightChain1 6018243, 15885, 23527, 31169, 38811, 46453, 54095Neliximab_HeavyChain_VH-Region 602 8244, 15886, 23528, 31170, 38812,46454, 54096 Neliximab_HeavyChain_VH-Region_variant1 603 8245, 15887,23529, 31171, 38813, 46455, 54097 Neliximab_LightChain_VL-Region 6048246, 15888, 23530, 31172, 38814, 46456, 54098Neliximab_LightChain_VL-Region_variant1 605 8247, 15889, 23531, 31173,38815, 46457, 54099 Nemolizumab_HeavyChain1 606 8248, 15890, 23532,31174, 38816, 46458, 54100 Nemolizumab_LightChain1 607 8249, 15891,23533, 31175, 38817, 46459, 54101 Nesvacumab_HeavyChain1 608 8250,15892, 23534, 31176, 38818, 46460, 54102 Nesvacumab_LightChain1 6098251, 15893, 23535, 31177, 38819, 46461, 54103 Neuradiab_HeavyChain1 6108252, 15894, 23536, 31178, 38820, 46462, 54104 Neuradiab_LightChain1 6118253, 15895, 23537, 31179, 38821, 46463, 54105 Nimotuzumab_HeavyChain1612 8254, 15896, 23538, 31180, 38822, 46464, 54106Nimotuzumab_LightChain1 613 8255, 15897, 23539, 31181, 38823, 46465,54107 Nivolumab_HeavyChain1 614 8256, 15898, 23540, 31182, 38824, 46466,54108 Nivolumab_LightChain1 615 8257, 15899, 23541, 31183, 38825, 46467,54109 Obiltoxaximab_HeavyChain1 616 8258, 15900, 23542, 31184, 38826,46468, 54110 Obiltoxaximab_LightChain1 617 8259, 15901, 23543, 31185,38827, 46469, 54111 Obinutuzumab_HeavyChain1 618 8260, 15902, 23544,31186, 38828, 46470, 54112 Obinutuzumab_LightChain1 619 8261, 15903,23545, 31187, 38829, 46471, 54113 Ocaratuzumab_HeavyChain1 620 8262,15904, 23546, 31188, 38830, 46472, 54114 Ocaratuzumab_LightChain1 6218263, 15905, 23547, 31189, 38831, 46473, 54115 Ocrelizumab_HeavyChain1622 8264, 15906, 23548, 31190, 38832, 46474, 54116Ocrelizumab_LightChain1 623 8265, 15907, 23549, 31191, 38833, 46475,54117 Ofatumumab_HeavyChain1 624 8266, 15908, 23550, 31192, 38834,46476, 54118 Ofatumumab_LightChain1 625 8267, 15909, 23551, 31193,38835, 46477, 54119 Olaratumab_HeavyChain1 626 8268, 15910, 23552,31194, 38836, 46478, 54120 Olaratumab_LightChain1 627 8269, 15911,23553, 31195, 38837, 46479, 54121 Olizuab_HeavyChain1 628 8270, 15912,23554, 31196, 38838, 46480, 54122 Olizuab_LightChain1 629 8271, 15913,23555, 31197, 38839, 46481, 54123 Olokizumab_HeavyChain1 630 8272,15914, 23556, 31198, 38840, 46482, 54124 Olokizumab_LightChain1 6318273, 15915, 23557, 31199, 38841, 46483, 54125 Omalizumab_HeavyChain 6328274, 15916, 23558, 31200, 38842, 46484, 54126 Omalizumab_LightChain 6338275, 15917, 23559, 31201, 38843, 46485, 54127 Onartuzumab_HeavyChain1634 8276, 15918, 23560, 31202, 38844, 46486, 54128Onartuzumab_HeavyChain2 635 8277, 15919, 23561, 31203, 38845, 46487,54129 Onartuzumab_LightChain1 636 8278, 15920, 23562, 31204, 38846,46488, 54130 Ontuxizumab_HeavyChain1 637 8279, 15921, 23563, 31205,38847, 46489, 54131 Ontuxizumab_LightChain1 638 8280, 15922, 23564,31206, 38848, 46490, 54132 Opicinumab_HeavyChain1 639 8281, 15923,23565, 31207, 38849, 46491, 54133 Opicinumab_LightChain1 640 8282,15924, 23566, 31208, 38850, 46492, 54134 Oportuzumab_monatox_HeavyChain1641 8283, 15925, 23567, 31209, 38851, 46493, 54135Oportuzumab_monatox_SingleChain_variable_fragment 642 8284, 15926,23568, 31210, 38852, 46494, 54136 Oreptacog_alfa_HeavyChain1 643 8285,15927, 23569, 31211, 38853, 46495, 54137 Oreptacog_alfa_LightChain1 6448286, 15928, 23570, 31212, 38854, 46496, 54138 Orticumab_HeavyChain1 6458287, 15929, 23571, 31213, 38855, 46497, 54139 Orticumab_LightChain1 6468288, 15930, 23572, 31214, 38856, 46498, 54140 Otelixizumab_HeavyChain1647 8289, 15931, 23573, 31215, 38857, 46499, 54141Otelixizumab_LightChain1 648 8290, 15932, 23574, 31216, 38858, 46500,54142 Otlertuzumab_HeavyChain1 649 8291, 15933, 23575, 31217, 38859,46501, 54143 Oxelumab_HeavyChain1 650 8292, 15934, 23576, 31218, 38860,46502, 54144 Oxelumab_LightChain1 651 8293, 15935, 23577, 31219, 38861,46503, 54145 Ozanezumab_HeavyChain1 652 8294, 15936, 23578, 31220,38862, 49504, 54146 Ozanezumab_LightChain1 653 8295, 15937, 23579,31221, 38863, 46505, 54147 Ozoralizumab_HeavyChain1 654 8296, 15938,23580, 31222, 38864, 46506, 54148 Palivizumab_HeavyChain 655 8297,15939, 23581, 31223, 38865, 46507, 54149 Palivizumab_LightChain 6568298, 15940, 23582, 31224, 38866, 46508, 54150 Palivizumab_VH-Region 6578299, 15941, 23583, 31225, 38867, 46509, 54151 Pamrevlumab_HeavyChain1658 8300, 15942, 23584, 31226, 38868, 46510, 54152Pamrevlumab_LightChain1 659 8301, 15943, 23585, 31227, 38869, 46511,54153 Panitumumab_HeavyChain1 660 8302, 15944, 23586, 31228, 38870,46512, 54154 Panitumumab_LightChain1 661 8303, 15945, 23587, 31229,38871, 46513, 54155 Pankoab_HeavyChain1 662 8304, 15946, 23588, 31230,38872, 46514, 54156 Pankoab_LightChain1 663 8305, 15947, 23589, 31231,38873, 46515, 54157 Pankoab_LightChain2 664 8306, 15948, 23590, 31232,38874, 46516, 54158 PankoMab_HeavyChain_VDJ-Region 665 8307, 15949,23591, 31233, 38875, 46517, 54159 PankoMab_LightChain_VJ-Region 6668308, 15950, 23592, 31234, 38876, 46518, 54160 Panobacumab_HeavyChain1667 8309, 15951, 23593, 31235, 38877, 46519, 54161Panobacumab_LightChain1 668 8310, 15952, 23594, 31236, 38878, 46520,54162 Panobacumab_LightChain2 669 8311, 15953, 23595, 31237, 38879,46521, 54163 Parsatuzumab_HeavyChain1 670 8312, 15954, 23596, 31238,38880, 46522, 54164 Parsatuzumab_LightChain1 671 8313, 15955, 23597,31239, 38881, 46523, 54165 Pascolizumab_HeavyChain1 672 8314, 15956,23598, 31240, 38882, 46524, 54166 Pascolizumab_LightChain1 673 8315,15957, 23599, 31241, 38883, 46525, 54167 Pasotuxizumab_HeavyChain1 6748316, 15958, 23600, 31242, 38884, 46526, 54168 Pasotuxizumab_SingleChain675 8317, 15959, 23601, 31243, 38885, 46527, 54169Pateclizumab_HeavyChain1 676 8318, 15960, 23602, 31244, 38886, 46528,54170 Pateclizumab_LightChain1 677 8319, 15961, 23603, 31245, 38887,46529, 54171 Patritumab_HeavyChain1 678 8320, 15962, 23604, 31246,38888, 46530, 54172 Patritumab_hinge-CH2—CH3 679 8321, 15963, 23605,31247, 38889, 46531, 54173 Patritumab_LightChain1 680 8322, 15964,23606, 31248, 38890, 46532, 54174 Pembrolizumab_HeavyChain1 681 8323,15965, 23607, 31249, 38891, 46533, 54175 Pembrolizumab_LightChain1 6828324, 15966, 23608, 31250, 38892, 46534, 54176 Perakizumab_HeavyChain1683 8325, 15967, 23609, 31251, 38893, 46535, 54177Perakizumab_LightChain1 684 8326, 15968, 23610, 31252, 38894, 46536,54178 Pertuzuab_HeavyChain1 685 8327, 15969, 23611, 31253, 38895, 46537,54179 Pertuzuab_LightChain1 686 8328, 15970, 23612, 31254, 38896, 46538,54180 Pertuzumab_HeavyChain 687 8329, 15971, 23613, 31255, 38897, 46539,54181 Pertuzumab_LightChain 688 8330, 15972, 23614, 31256, 38898, 46540,54182 Pexelizumab_h5g1.1-scFv 689 8331, 15973, 23615, 31257, 38899,46541, 54183 Pexelizumab_h5g1.1VHC_+_F_Heavy_Chain_V-Region 690 8332,15974, 23616, 31258, 38900, 46542, 54184Pexelizumab_h5g1.1VHC_+_F_Light_Chain_V-Region 691 8333, 15975, 23617,31259, 38901, 46543, 54185 PF-05082566_HeavyChain1 692 8334, 15976,23618, 31260, 38902, 46544, 54186 PF-05082568_LightChain1 693 8335,15977, 23619, 31261, 38903, 46545, 54187 Pidilizumab_HeavyChain1 6948336, 15978, 23620, 31262, 38904, 46546, 54188 Pidilizumab_LightChain1695 8337, 15979, 23621, 31263, 38905, 46547, 54189Pinatuzumab_vedotin_HeavyChain1 696 8338, 15980, 23622, 31264, 38906,46548, 54190 Pinatuzumab_vedotin_LightChain1 697 8339, 15981, 23623,31265, 38907, 46549, 54191 Placulumab_chain1 698 8340, 15982, 23624,31266, 38908, 46550, 54192 Placulumab_HeavyChain1 699 8341, 15983,23625, 31267, 38909, 46551, 54193 Plozalizumab_HeavyChain1 700 8342,15984, 23626, 31268, 38910, 46552, 54194 Plozalizumab_LightChain1 7018343, 15985, 23627, 31269, 38911, 46553, 54195 Pogalizumab_HeavyChain1702 8344, 15986, 23628, 31270, 38912, 46554, 54196Pogalizumab_LightChain1 703 8345, 15987, 23629, 31271, 38913, 46555,54197 Polatuzumab_vedotin_HeavyChain1 704 8346, 15988, 23630, 31272,38914, 46556, 54198 Polatuzumab_vedotin_LightChain1 705 8347, 15989,23631, 31273, 38915, 46557, 54199 Ponezumab_HeavyChain1 706 8348, 15990,23632, 31274, 38916, 46558, 54200 Ponezumab_LightChain1 707 8349, 15991,23633, 31275, 38917, 46559, 54201 Pritoxaximab_HeavyChain1 708 8350,15992, 23634, 31276, 38918, 46560, 54202 Pritoxaximab_LightChain1 7098351, 15993, 23635, 31277, 38919, 46561, 54203 Pritumumab_HeavyChain1710 8352, 15994, 23636, 31278, 38920, 46562, 54204Pritumumab_LightChain1 711 8353, 15995, 23637, 31279, 38921, 46563,54205 Quilizumab_HeavyChain1 712 8354, 15996, 23638, 31280, 38922,46564, 54206 Quilizumab_LightChain1 713 8355, 15997, 23639, 31281,38923, 46565, 54207 Racotumomab_HeavyChain1 714 8356, 15998, 23640,31282, 38924, 46566, 54208 Racotumomab_LightChain1 715 8357, 15999,23641, 31283, 38925, 46567, 54209 Racotumomab_scVH-VH′-VH_chain 7168358, 16000, 23642, 31284, 38926, 46568, 54210 Radretumab_HeavyChain1717 8359, 16001, 23643, 31285, 38927, 46569, 54211 Radretumab_j_chain718 8360, 16002, 23644, 31286, 38928, 46570, 54212Rafivirumab_HeavyChain1 719 8361, 16003, 23645, 31287, 38929, 46571,54213 Rafivirumab_HeavyChain 720 8362, 16004, 23646, 31288, 38930,46572, 54214 Rafivirumab_LightChain1 721 8363, 16005, 23647, 31289,38931, 46573, 54215 Rafivirumab_LightChain 722 8364, 16006, 23648,31290, 38932, 46574, 54216 Ralpancizumab_HeavyChain1 723 8365, 16007,23649, 31291, 38933, 46575, 54217 Ralpancizumab_LightChain1 724 8366,16008, 23650, 31292, 38934, 46576, 54218 Ramucirumab_HeavyChain1 7258367, 16009, 23651, 31293, 38935, 46577, 54219 Ramucirumab_LightChain1726 8368, 16010, 23652, 31294, 38936, 46578, 54220Ranibiziuab_HeavyChain1 727 8369, 16011, 23653, 31295, 38937, 46579,54221 Ranibiziuab_LightChain1 728 8370, 16012, 23654, 31296, 38938,46580, 54222 Ranibizumab_fab_fragment 729 8371, 16013, 23655, 31297,38939, 46581, 54223 Ranibizumab_HeavyChain 730 8372, 16014, 23656,31298, 38940, 46582, 54224 Ranibizumab_LightChain 731 8373, 16015,23657, 31299, 38941, 46583, 54225 Ranibizumab_LightChain_variant 7328374, 16016, 23658, 31300, 38942, 46584, 54226 Refanezumab_HeavyChain1733 8375, 16017, 23659, 31301, 38943, 46585, 54227Refanezumab_LightChain1 734 8376, 16018, 23660, 31302, 38944, 46586,54228 REGN2810_HeavyChain1 735 8377, 16019, 23661, 31303, 38945, 46587,54229 REGN2810_LightChain1 736 8378, 16020, 23662, 31304, 38946, 46588,54230 rhuMab_HER2(9CI)_LightChain 737 8379, 16021, 23663, 31305, 38947,46589, 54231 rhuMab_HER2_HeavyChain 738 8380, 16022, 23664, 31306,38948, 46590, 54232 rhuMab_HER2_LightChain 739 8381, 16023, 23665,31307, 38949, 46591, 54233 rhuMab_HER2_LightChain_variant1 740 8382,16024, 23666, 31308, 38950, 46592, 54234 rhuMab_HER2_LightChain_variant2741 8383, 16025, 23667, 31309, 38951, 46593, 54235rhuMab_HER2_LightChain_variant3 742 8384, 16026, 23668, 31310, 38952,46594, 54236 rhuMab_HER2_LightChain_variant4 743 8385, 16027, 23669,31311, 38953, 46595, 54237 rhuMab_HER2_LightChain_V-Region 744 8386,16028, 23670, 31312, 38954, 46596, 54238 rhuMab_HER2_gamma1-Chain 7458387, 16029, 23671, 31313, 38955, 46597, 54239 rhuMab_HER2_gamma1-Chain746 8388, 16030, 23672, 31314, 38956, 46598, 54240 rhuMab_HER2_gamma1-747 8389, 16031, 23673, 31315, 38957, 46599, 54241Chain_rhuMab_HER2_LightChain_sc405 rhuMab_HER2_gamma1-Chain_variant1 7488390, 16032, 23674, 31316, 38958, 46600, 54242rhuMab_HER2_gamma1-Chain_variant2 749 8391, 16033, 23675, 31317, 38959,46601, 54243 rhuMab_HER2_gamma1-Chain_variant3 750 8392, 16034, 23676,31318, 38960, 46602, 54244 rhuMab_HER2_gamma1-Chain_V-Region 751 8393,16035, 23677, 31319, 38961, 46603, 54245 rhuMab-VEGF_HeavyChain1 7528394, 16036, 23678, 31320, 38962, 46604, 54246 rhuMab-VEGF_LightChain1753 8395, 16037, 23679, 31321, 38963, 46605, 54247rhuMAb-VEGF_LightChain 754 8396, 16038, 23680, 31322, 38964, 46606,54248 rhuMAb-VEGF_LightChain_VG-Region 755 8397, 16039, 23681, 31323,38965, 46607, 54249 rhuMAb-VEGF_gamma1-Chain 756 8398, 16040, 23682,31324, 38966, 46608, 54250 rhuMAb-VEGF_gamma1-Chain_VDG-Region 757 8399,16041, 23683, 31325, 38967, 46609, 54251 Rilotumumab_HeavyChain1 7588400, 16042, 23684, 31326, 38968, 46610, 54252 Rilotumumab_LightChain1759 8401, 16043, 23685, 31327, 38969, 46611, 54253Rilotumumab_scFv-CH_chain 760 8402, 16044, 23686, 31328, 38970, 46612,54254 Rinucumab_HeavyChain1 761 8403, 16045, 23687, 31329, 38971, 46613,54255 Rinucumab_HeavyChain 762 8404, 16046, 23688, 31330, 38972, 46614,54256 Rinucumab_LightChain1 763 8405, 16047, 23689, 31331, 38973, 46615,54257 Risankizumab_HeavyChain1 764 8406, 16048, 23690, 31332, 38974,46616, 54258 Risankizumab_LightChain1 765 8407, 16049, 23691, 31333,38975, 46617, 54259 Rituximab_HeavyChain 766 8408, 16050, 23692, 31334,38976, 46618, 54260 Rituximab_HeavyChain_variant 767 8409, 16051, 23693,31335, 38977, 46619, 54261 Rituximab_LightChain 768 8410, 16052, 23694,31336, 38978, 46620, 54262 Rivabazumab_pegol_HeavyChain1 769 8411,16053, 23695, 31337, 38979, 46621, 54263 Rivabazumab_pegol_LightChain1770 8412, 16054, 23696, 31338, 38980, 46622, 54264Robatumumab_HeavyChain1 771 8413, 16055, 23697, 31339, 38981, 46623,54265 Robatumumab_LightChain1 772 8414, 16056, 23698, 31340, 38982,46624, 54266 Roledumab_HeavyChain1 773 8415, 16057, 23699, 31341, 38983,46625, 54267 Roledumab_LightChain1 774 8416, 16058, 23700, 31342, 38984,46626, 54268 Romosozumab_fab_fragment 775 8417, 16059, 23701, 31343,38985, 46627, 54269 Romosozumab_HeavyChain1 776 8418, 16060, 23702,31344, 38986, 46628, 54270 Romosozumab_LightChain1 777 8419, 16061,23703, 31345, 38987, 46629, 54271 Rontalizuab_HeavyChain1 778 8420,16062, 23704, 31346, 38988, 46630, 54272 Rontalizuab_LightChain1 7798421, 16063, 23705, 31347, 38989, 46631, 54273 Rontalizumab_HeavyChain1780 8422, 16064, 23706, 31348, 38990, 46632, 54274Rontalizumab_LightChain1 781 8423, 16065, 23707, 31349, 38991, 46633,54275 Rovalpituzumab_tesirine_HeavyChain1 782 8424, 16066, 23708, 31350,38992, 46634, 54276 Rovalpituzumab_tesirine_LightChain1 783 8425, 16067,23709, 31351, 38993, 46635, 54277 Rovelizumab_HeavyChain1 784 8426,16068, 23710, 31352, 38994, 46636, 54278 Rovelizumab_LightChain1 7858427, 16069, 23711, 31353, 38995, 46637, 54279 Ruplizumab_HeavyChain1786 8428, 16070, 23712, 31354, 38996, 46638, 54280Ruplizumab_LightChain1 787 8429, 16071, 23713, 31355, 38997, 46639,54281 Sacituzumab_govitecan_HeavyChain1 788 8430, 16072, 23714, 31356,38998, 46640, 54282 Sacituzumab_govitecan_LightChain1 789 8431, 16073,23715, 31357, 38999, 46641, 54283 Samalizumab_HeavyChain1 790 8432,16074, 23716, 31358, 39000, 46642, 54284 Samalizumab_LightChain1 7918433, 16075, 23717, 31359, 39001, 46643, 54285 Sarilumab_HeavyChain1 7928434, 16076, 23718, 31360, 39002, 46644, 54286 Sarilumab_LightChain1 7938435, 16077, 23719, 31361, 39003, 46645, 54287Satumomab_pendetide_HeavyChain 794 8436, 16078, 23720, 31362, 39004,46646, 54288 Satumomab_pendetide_LightChain 795 8437, 16079, 23721,31363, 39005, 46647, 54289 Secukinumab_HeavyChain1 796 8438, 16080,23722, 31364, 39006, 46648, 54290 Secukinumab_LightChain1 797 8439,16081, 23723, 31365, 39007, 46649, 54291 Seribantumab_HeavyChain1 7988440, 16082, 23724, 31366, 39008, 46650, 54292 Seribantumab_LightChain1799 8441, 16083, 23725, 31367, 39009, 46651, 54293Setoxaximab_HeavyChain1 800 8442, 16084, 23726, 31368, 39010, 46652,54294 Setoxaximab_LightChain1 801 8443, 16085, 23727, 31369, 39011,46653, 54295 Sifalimumab_HeavyChain1 802 8444, 16086, 23728, 31370,39012, 46654, 54296 Sifalimumab_LightChain1 803 8445, 16087, 23729,31371, 39013, 46655, 54297 Siltuximab_HeavyChain1 804 8446, 16088,23730, 31372, 39014, 46656, 54298 Siltuximab_LightChain1 805 8447,16089, 23731, 31373, 39015, 46657, 54299 Simtuzumab_HeavyChain1 8068448, 16090, 23732, 31374, 39016, 46658, 54300 Simtuzumab_LightChain1807 8449, 16091, 23733, 31375, 39017, 46659, 54301 Sirukumab_HeavyChain1808 8450, 16092, 23734, 31376, 39018, 46660, 54302 Sirukumab_LightChain1809 8451, 16093, 23735, 31377, 39019, 46661, 54303Sofituzumab_vedotin_HeavyChain1 810 8452, 16094, 23736, 31378, 39020,46662, 54304 Sofituzumab_vedotin_LightChain1 811 8453, 16095, 23737,31379, 39021, 46663, 54305 Solanezumab_HeavyChain1 812 8454, 16096,23738, 31380, 39022, 46664, 54306 Solanezumab_HeavyChain 813 8455,16097, 23739, 31381, 39023, 46665, 54307 Solanezumab_LightChain1 8148456, 16098, 23740, 31382, 39024, 46666, 54308 Solitomab_HeavyChain1 8158457, 16099, 23741, 31383, 39025, 46667, 54309 Solitomab_SingleChain 8168458, 16100, 23742, 31384, 39026, 46668, 54310Sonepcizumab_LightChain_Precursor 817 8459, 16101, 23743, 31385, 39027,46669, 54311 Sonepcizumab_gamma1-Chain_Precursor 818 8460, 16102, 23744,31386, 39028, 46670, 54312 Stamulumab_HeavyChain1 819 8461, 16103,23745, 31387, 39029, 46671, 54313 Stamulumab_LightChain1 820 8462,16104, 23746, 31388, 39030, 46672, 54314 Suptavumab_HeavyChain1 8218463, 16105, 23747, 31389, 39031, 46673, 54315 Suptavumab_LightChain1822 8464, 16106, 23748, 31390, 39032, 46674, 54316 Suvizumab_HeavyChain1823 8465, 16107, 23749, 31391, 39033, 46675, 54317 Suvizumab_LightChain1824 8466, 16108, 23750, 31392, 39034, 46676, 54318 Tabalumab_HeavyChain1825 8467, 16109, 23751, 31393, 39035, 46677, 54319 Tabalumab_LightChain1826 8468, 16110, 23752, 31394, 39036, 46678, 54320Tacatuzuab_HeavyChain1 827 8469, 16111, 23753, 31395, 39037, 46679,54321 Tacatuzuab_LightChain1 828 8470, 16112, 23754, 31396, 39038,46680, 54322 Tadocizumab_fab_fragment_HeavyChain 829 8471, 16113, 23755,31397, 39039, 46681, 54323 Tadocizumab_fab_fragment_LightChain 830 8472,16114, 23756, 31398, 39040, 46682, 54324 Talizumab_HeavyChain1 831 8473,16115, 23757, 31399, 39041, 46683, 54325 Talizumab_LightChain1 832 8474,16116, 23758, 31400, 39042, 46684, 54326 Tamtuvetmab_HeavyChain1 8338475, 16117, 23759, 31401, 39043, 46685, 54327 Tamtuvetmab_LightChain1834 8476, 16118, 23760, 31402, 39044, 46686, 54328 Tanezumab_HeavyChain835 8477, 16119, 23761, 31403, 39045, 46687, 54329 Tanezumab_LightChain836 8478, 16120, 23762, 31404, 39046, 46688, 54330Tarextumab_HeavyChain1 837 8479, 16121, 23763, 31405, 39047, 46689,54331 Tarextumab_LightChain1 838 8480, 16122, 23764, 31406, 39048,46690, 54332 Tefibazumab_HeavyChain1 839 8481, 16123, 23765, 31407,39049, 46691, 54333 Tefibazumab_LightChain1 840 8482, 16124, 23766,31408, 39050, 46692, 54334 Tenatumomab_HeavyChain1 841 8483, 16125,23767, 31409, 39051, 46693, 54335 Tenatumomab_LightChain1 842 8484,16126, 23768, 31410, 39052, 46694, 54336 Teneliximab_HeavyChain1 8438485, 16127, 23769, 31411, 39053, 46695, 54337 Teneliximab_LightChain1844 8486, 16128, 23770, 31412, 39054, 46696, 54338Teplizumab_HeavyChain1 845 8487, 16129, 23771, 31413, 39055, 46697,54339 Teplizumab_LightChain1 846 8488, 16130, 23772, 31414, 39056,46698, 54340 Teprotumumab_HeavyChain1 847 8489, 16131, 23773, 31415,39057, 46699, 54341 Teprotumumab_LightChain1 848 8490, 16132, 23774,31416, 39058, 46700, 54342 Tesidolumab_HeavyChain1 849 8491, 16133,23775, 31417, 39059, 46701, 54343 Tesidolumab_LightChain1 850 8492,16134, 23776, 31418, 39060, 46702, 54344 Tezepelumab_HeavyChain1 8518493, 16135, 23777, 31419, 39061, 46703, 54345 Tezepelumab_LightChain1852 8494, 16136, 23778, 31420, 39162, 46704, 54346ThioMAb-chMA79b-HC(A118C)_HeavyChain 853 8495, 16137, 23779, 31421,39063, 46705, 54347 ThioMab-hu10A8.v1-HC(A118C)_HeavyChain 854 8496,16138, 23780, 31422, 39064, 46706, 54348ThioMab-hu10A8.v1-HC(V205C)_HeavyChain 855 8497, 16139, 23781, 31423,39065, 46707, 54349 ThioMab-hu10A8.v1-LC(A118C)_LightChain 856 8498,16140, 23782, 31424, 39066, 46708, 54350ThioMab-hu10AB.v1-LC(V205C)_LightChain 857 8499, 16141, 23783, 31425,39067, 46709, 54351 ThioMAb-huMA79b.v17-HC(A118C)_HeavyChain 858 8500,16142, 23784, 31426, 39068, 46710, 54352ThioMAb-huMA79b.v17-HC(A118C)_LightChain 859 8501, 16143, 23785, 31427,39069, 46711, 54353 ThioMAb-huMA79b.v18-HC(A118C)_HeavyChain 860 8502,16144, 23786, 31428, 39070, 46712, 54354ThioMAb-huMA79b.v28-HC(A118C)_LightChain 861 8503, 16145, 23787, 31429,39071, 46713, 54355 ThioMAb-huMA79b.v28-LC(V205C)_LightChain 862 8504,16146, 23788, 31430, 39072, 46714, 54356 Ticiliuab_HeavyChain1 863 8505,16147, 23789, 31431, 39073, 46715, 54357 Ticilivab_LightChain1 864 8506,16148, 23790, 31432, 39074, 46716, 54358 Tigatuzumab_HeavyChain1 8658507, 16149, 23791, 31433, 39075, 46717, 54359 Tigatuzumab_HeavyChain866 8508, 16150, 23792, 31434, 39076, 46718, 54360Tigatuzumab_LightChain1 867 8509, 16151, 23793, 31435, 39077, 46719,54361 Tigatuzumab_LightChain 868 8510, 16152, 23794, 31436, 39078,46720, 54362 Tildrakizumab_HeavyChain1 869 8511, 16153, 23795, 31437,39079, 46721, 54363 Tildrakizumab_LightChain1 870 8512, 16154, 23796,31438, 39080, 46722, 54364 Tisotumab_vedotin_HeavyChain1 871 8513,16155, 23797, 31439, 39081, 46723, 54365 Tisotumab_vedotin_LightChain1872 8514, 16156, 23798, 31440, 39082, 46724, 54366Tocilizumab_HeavyChain1 873 8515, 16157, 23799, 31441, 39083, 46725,54367 Tocilizumab_LightChain1 874 8516, 16158, 23800, 31442, 39084,46726, 54368 Tosatoxumab_HeavyChain1 875 8517, 16159, 23801, 31443,39085, 46727, 54369 Tosatoxumab_LightChain1 876 8518, 16160, 23802,31444, 39086, 46728, 54370 Tositumomab_HeavyChain 877 8519, 16161,23803, 31445, 39087, 46729, 54371 Tositumomab_LightChain 878 8520,16162, 23804, 31446, 39088, 46730, 54372 Tovetumab_HeavyChain1 879 8521,16163, 23805, 31447, 39089, 46731, 54373 Tovetumab_LightChain1 880 8522,16164, 23806, 31448, 39090, 46732, 54374 Tralokinumab_HeavyChain1 8818523, 16165, 23807, 31449, 39091, 46733, 54375 Tralokinumab_LightChain1882 8524, 16166, 23808, 31450, 39092, 46734, 54376Trastuzuab_HeavyChain1 883 8525, 16167, 23809, 31451, 39093, 46735,54377 Trastuzuab_LightChain1 884 8526, 16168, 23810, 31452, 39094,46736, 54378 Trastuzumab_emtansine_HeavyChain1 885 8527, 16169, 23811,31453, 39095, 46737, 54379 Trastuzumab_emtansine_LightChain1 886 8528,16170, 23812, 31454, 39096, 46738, 54380 Trastuzumab_HeavyChain1 8878529, 16171, 23813, 31455, 39097, 46739, 54381 Trastuzumab_HeavyChain888 8530, 16172, 23814, 31456, 39098, 46740, 54382Trastuzumab_HeavyChain_variant_1n8z_B 889 8531, 16173, 23815, 31457,39099, 46741, 54383 Trastuzumab_HeavyChain_variant_7637_H 890 8532,16174, 23816, 31458, 39100, 46742, 54384 Trastuzumab_LightChain1 8918533, 16175, 23817, 31459, 39101, 46743, 54385Trastuzumab_LightChain_variant_1n8z_A 892 8534, 16176, 23818, 31460,39102, 46744, 54386 Trastuzumab_LightChain_variant_7637_L 893 8535,16177, 23819, 31461, 39103, 46745, 54387 TRC-105_HeavyChain1 894 8536,16178, 23820, 31462, 39104, 46746, 54388 TRC-105_LightChain1 895 8537,16179, 23821, 31463, 39105, 46747, 54389 Tregalizumab_HeavyChain1 8968538, 16180, 23822, 31464, 39106, 46748, 54390 Tregalizumab_LightChain1897 8539, 16181, 23823, 31465, 39107, 46749, 54391Tremelimumab_HeavyChain1 898 8540, 16182, 23824, 31466, 39108, 46750,54392 Tremelimumab_LightChain1 899 8541, 16183, 23825, 31467, 39109,46751, 54393 Trevogrumab_HeavyChain1 900 8542, 16184, 23826, 31468,39110, 46752, 54394 Trevogrumab_LightChain1 901 8543, 16185, 23827,31469, 39111, 46753, 54395 Tucotuzumab_celmoleukin_HeavyChain1 902 8544,16186, 23828, 31470, 39112, 46754, 54396Tucotuzumab_celmoleukin_LightChain1 903 8545, 16187, 23829, 31471,39113, 46755, 54397 Ublituximab_HeavyChain1 904 8546, 16188, 23830,31472, 39114, 46756, 54398 Ublituximab_LightChain1 905 8547, 16189,23831, 31473, 39115, 46757, 54399 Ulocuplumab_HeavyChain1 906 8548,16190, 23832, 31474, 39116, 46758, 54400 Ulocuplumab_LightChain1 9078549, 16191, 23833, 31475, 39117, 46759, 54401 Urelumab_HeavyChain1 9088550, 16192, 23834, 31476, 39118, 46760, 54402 Urelumab_LightChain1 9098551, 16193, 23835, 31477, 39119, 46761, 54403 Urtoxazumab_HeavyChain1910 8552, 16194, 23836, 31478, 39120, 46762, 54404Urtoxazumab_LightChain1 911 8553, 16195, 23837, 31479, 39121, 46763,54405 Ustekinumab_HeavyChain1 912 8554, 16196, 23838, 31480, 39122,46764, 54406 Ustekinumab_LightChain1 913 8555, 16197, 23839, 31481,39123, 46765, 54407 Vadastuximab_talirine_HeavyChain1 914 8556, 16198,23840, 31482, 39124, 46766, 54408 Vadastuximab_talirine_LightChain1 9158557, 16199, 23841, 31483, 39125, 46767, 54409Vandortuzumab_vedotin_HeavyChain1 916 8558, 16200, 23842, 31484, 39126,46768, 54410 Vandortuzumab_vedotin_LightChain1 917 8559, 16201, 23843,31485, 39127, 46769, 54411 Vantictumab_HeavyChain1 918 8560, 16202,23844, 31486, 39128, 46770, 54412 Vantictumab_LightChain1 919 8561,16203, 23845, 31487, 39129, 46771, 54413 Vanucizumab_HeavyChain1 9208562, 16204, 23846, 31488, 39130, 46772, 54414 Vanucizumab_HeavyChain2921 8563, 16205, 23847, 31489, 39131, 46773, 54415Vanucizumab_LightChain1 922 8564, 16206, 23848, 31490, 39132, 46774,54416 Vanucizumab_LightChain2 923 8565, 16207, 23849, 31491, 39133,46775, 54417 Varlilumab_HeavyChain1 924 8566, 16208, 23850, 31492,39134, 46776, 54418 Varlilumab_LightChain1 925 8567, 16209, 23851,31493, 39135, 46777, 54419 Vatelizumab_HeavyChain1 926 8568, 16210,23852, 31494, 39136, 46778, 54420 Vatelizumab_LightChain1 927 8569,16211, 23853, 31495, 39137, 46779, 54421 Vedolizumab_HeavyChain1 9288570, 16212, 23854, 31496, 39138, 46780, 54422 Vedolizumab_LightChain1929 8571, 16213, 23855, 31497, 39139, 46781, 54423Veltuzumab_HeavyChain1 930 8572, 16214, 23856, 31498, 39140, 46782,54424 Veltuzumab_LightChain1 931 8573, 16215, 23857, 31499, 39141,46783, 54425 Vesencumab_HeavyChain1 932 8574, 16216, 23858, 31500,39142, 46784, 54426 Vesencumab_LightChain1 933 8575, 16217, 23859,31501, 39143, 46785, 54427 Visilizumab_HeavyChain1 934 8576, 16218,23860, 31502, 39144, 46786, 54428 Visilizumab_LightChain1 935 8577,16219, 23861, 31503, 39145, 46787, 54429 Volociximab_HeavyChain 9368578, 16220, 23862, 31504, 39146, 46788, 54430 Volociximab_LightChain937 8579, 16221, 23863, 31505, 39147, 46789, 54431Vorsetuzumab_HeavyChain1 938 8580, 16222, 23864, 31506, 39148, 46790,54432 Vorsetuzumab_LightChain1 939 8581, 16223, 23865, 31507, 39149,46791, 54433 Vorsetuzumab_mafodotin_HeavyChain1 940 8582, 16224, 23866,31508, 39150, 46792, 54434 Vorsetuzumab_mafodotin_LightChain1 941 8583,16225, 23867, 31509, 39151, 46793, 54435Yttrium_(90Y)_clivatuzumab_tetraxetan_HeavyChain1 942 8584, 16226,23868, 31510, 39152, 46794, 54436Yttrium_(90Y)_clivatuzumab_tetraxetan_LightChain1 943 8585, 16227,23869, 31511, 39153, 46795, 54437Yttrium_Y_90_epratuzumab_tetraxetan_HeavyChain1 944 8586, 16228, 23870,31512, 39154, 46796, 54438Yttrium_Y_90_epratuzumab_tetraxetan_LightChain1 945 8587, 16229, 23871,31513, 39155, 46797, 54439 Yttrium_Y_90_epratuzumab_HeavyChain1 9468588, 16230, 23872, 31514, 39156, 46798, 54440Yttrium_Y_90_epratuzumab_LightChain1 947 8589, 16231, 23873, 31515,39157, 46799, 54441 Zalutumumab_HeavyChain1 948 8590, 16232, 23874,31516, 39158, 46800, 54442 Zalutumumab_LightChain1 949 8591, 16233,23875, 31517, 39159, 46801, 54443 Zanolimumab_H0_HeavyChain 950 8592,16234, 23876, 31518, 39160, 46802, 54444 Zanolimumab_L0_LightChain 9518593, 16235, 23877, 31519, 39161, 46803, 54445 Zatuximab_HeavyChain1 9528594, 16236, 23878, 31520, 39162, 46804, 54446 Zatuximab_LightChain1 9538595, 16237, 23879, 31521, 39163, 46805, 54447 Actoxumab_HeavyChain 9548596, 16238, 23880, 31522, 39164, 49806, 54448 Actoxumab_LightChain 9558597, 16239, 23881, 31523, 39165, 49807, 54449 Andecaliximab_HeavyChain956 8598, 16240, 23882, 31524, 39166, 49808, 54450Andecaliximab_LightChain 957 8599, 16241, 23883, 31525, 39167, 49809,54451 Aprutumab_HeavyChain 958 8600, 16242, 23884, 31526, 39168, 49810,54452 Aprutumab_LightChain 959 8601, 16243, 23885, 31527, 39169, 49811,54453 Azintuxizumab_HeavyChain 960 8602, 16244, 23886, 31528, 39170,49812, 54454 Azintuxizumab_LightChain 961 8603, 16245, 23887, 31529,39171, 49813, 54455 Blinatumomab_HeavyChain1 962 8604, 16246, 23888,31530, 39172, 49814, 54456 Blinatumomab_HeavyChain2 963 8605, 16247,23889, 31531, 39173, 49815, 54457Blinatumomab_LightChain_HeavyChain_HeavyChain_Light 964 8606, 16248,23890, 31532, 39174, 49816, 54458 Chain Blinatumomab_LightChain1 9658607, 16249, 23891, 31533, 39175, 49817, 54459 Blinatumomab_LightChain2966 8608, 16250, 23892, 31534, 39176, 49818, 54460 Brazikumab_HeavyChain967 8609, 16251, 23893, 31535, 39177, 49819, 54461 Brazikumab_LightChain968 8610, 16252, 23894, 31536, 39178, 49820, 54462Brolucizumab_HeavyChain 969 8611, 16253, 23895, 31537, 39179, 49821,54463 Brolucizumab_LightChain 970 8612, 16254, 23896, 31538, 39180,49822, 54464 Cabiralizumab_HeavyChain 971 8613, 16255, 23897, 31539,39181, 49823, 54465 Cabiralizumab_LightChain 972 8614, 16256, 23898,31540, 39182, 49824, 54466 Camrelizumab_HeavyChain 973 8615, 16257,23899, 31541, 39183, 49825, 54467 Camrelizumab_LightChain 974 8616,16258, 23900, 31542, 39184, 49826, 54468 Caplanizumab_HeavyChain 9758617, 16259, 23901, 31543, 39185, 49827, 54469Citatuzumab_bogatox_HeavyChain 976 8618, 16260, 23902, 31544, 39186,49828, 54470 Cosfroviximab_HeavyChain 977 8619, 16261, 23903, 31545,39187, 49829, 54471 Cosfroviximab_LightChain 978 8620, 16262, 23904,31546, 39188, 49830, 54472 Crizanlizumab_HeavyChain 979 8621, 16263,23905, 31547, 39189, 49831, 54473 Crizanlizumab_LightChain 980 8622,16264, 23906, 31548, 39190, 49832, 54474 Crotedumab_HeavyChain 981 8623,16265, 23907, 31549, 39191, 49833, 54475 Crotedumab_LightChain 982 8624,16266, 23908, 31550, 39192, 49834, 54476 Dezamizumab_HeavyChain 9838625, 16267, 23909, 31551, 39193, 49835, 54477 Dezamizumab_LightChain984 8626, 16268, 23910, 31552, 39194, 49836, 54478Duvortuxizumab_Chain1_scFv 985 8627, 16269, 23911, 31553, 39195, 49837,54479 Duvortuxizumab_Chain2_scfv 986 8628, 16270, 23912, 31554, 39196,46838, 54480 Duvortuxizumab_Chain3_h-CH2—CH3 987 8629, 16271, 23913,31555, 39197, 46839, 54481 Efungumab_HeavyChain 988 8630, 16272, 23914,31556, 39198, 46840, 54482 Efungumab_HeavyChain_LightChain 989 8631,16273, 23915, 31557, 39199, 46841, 54483 Efungumab_LightChain 990 8632,16274, 23916, 31558, 39200, 46842, 54484 Elezanumab_HeavyChain 991 8633,16275, 23917, 31559, 39201, 46843, 54485 Elezanumab_LightChain 992 8634,16276, 23918, 31560, 39202, 46844, 54486 Emapalumab_HeavyChain 993 8635,16277, 23919, 31561, 39203, 46845, 54487 Emapalumab_LightChain 994 8636,16278, 23920, 31562, 39204, 46846, 54488 Enoblituzumab_HeavyChain 9958637, 16279, 23921, 31563, 39205, 46847, 54489 Enoblituzumab_LightChain996 8638, 16280, 23922, 31564, 39206, 46848, 54490Eptinezumab_HeavyChain 997 8639, 16281, 23923, 31565, 39207, 46849,54491 Eptinezumab_LightChain 998 8640, 16282, 23924, 31566, 39208,46850, 54492 Erenumab_HeavyChain 999 8641, 16283, 23925, 31567, 39209,46851, 54493 Erenumab_LightChain 1000 8642, 16284, 23926, 31568, 39210,46852, 54494 Fremanezumab_HeavyChain 1001 8643, 16285, 23927, 31569,39211, 46853, 54495 Fremanezumab_LightChain 1002 8644, 16286, 23928,31570, 39212, 46854, 54496 Frunevetmab_HeavyChain 1003 8645, 16287,23929, 31571, 39213, 46855, 54497 Frunevetmab_LightChain 1004 8646,16288, 23930, 31572, 39214, 46856, 54498 Gatipotuzumab_HeavyChain 10058647, 16289, 23931, 31573, 39215, 46857, 54499 Gatipotuzumab_LightChain1006 8648, 16290, 23932, 31574, 39216, 46858, 54500 Gedivumab_HeavyChain1007 8649, 16291, 23933, 31575, 39217, 46859, 54501 Gedivumab_LightChain1008 8650, 16292, 23934, 31576, 39218, 46860, 54502Gemetuzumab_HeavyChain 1009 8651, 16293, 23935, 31577, 39219, 46861,54503 Gemetuzumab_LightChain 1010 8652, 16294, 23936, 31578, 39220,46862, 54504 Gilvetmab_HeavyChain 1011 8653, 16295, 23937, 31579, 39221,46863, 54505 Gilvetmab_LightChain 1012 8654, 16296, 23938, 31580, 39222,46864, 54506 Ifabotuzumab_HeavyChain 1013 8655, 16297, 23939, 31581,39223, 46865, 54507 Ifabotuzumab_LightChain 1014 8656, 16298, 23940,31582, 39224, 46866, 54508 Iratumumab_HeavyChain 1015 8657, 16299,23941, 31583, 39225, 46867, 54509 Iratumumab_LightChain 1016 8658,16300, 23942, 31584, 39226, 46868, 54510 Lacnotuzumab_HeavyChain 10178659, 16301, 23943, 31585, 39227, 46869, 54511 Lacnotuzumab_LightChain1018 8660, 16302, 23944, 31586, 39228, 46870, 54512Larcaviximab_HeavyChain 1019 8661, 16303, 23945, 31587, 39229, 46871,54513 Larcaviximab_LightChain 1020 8662, 16304, 23946, 31588, 39230,46872, 54514 Landalizumab_HeavyChain 1021 8663, 16305, 23947, 31589,39231, 46873, 54515 Landalizumab_LightChain 1022 8664, 16306, 23948,31590, 39232, 46874, 54516 Lesofavumab_HeavyChain 1023 8665, 16307,23949, 31591, 39233, 46875, 54517 Lesofavumab_LightChain 1024 8666,16308, 23950, 31592, 39234, 46875, 54518 Letolizumab_HeavyChain 10258667, 16309, 23951, 31593, 39235, 46877, 54519 Losatuxizumab_HeavyChain1026 8668, 16310, 23952, 31594, 39236, 46878, 54520Losatuxizumab_LightChain 1027 8669, 16311, 23953, 31595, 39237, 46879,54521 Lupartumab_HeavyChain 1028 8670, 16312, 23954, 31596, 39238,46880, 54522 Lupartumab_LightChain 1029 8671, 16313, 23955, 31597,39239, 46881, 54523 Lutikizumab_HeavyChain 1030 8672, 16314, 23956,31598, 39240, 46882, 54524 Lutikizumab_LightChain 1031 8673, 16315,23957, 31599, 39241, 46883, 54525 Oleclumab_HeavyChain 1032 8674, 16316,23958, 31600, 39242, 46884, 54526 Oleclumab_LightChain 1033 8675, 16317,23959, 31601, 39243, 46885, 54527 Otlertuzumab_HeavyChain 1034 8676,16318, 23960, 31602, 39244, 46886, 54528 Ozoralizumab_HeavyChain 10358677, 16319, 23961, 31603, 39245, 46887, 54529Ozoralizumab_HeavyChain_HeavyChain_HeavyChain 1036 8678, 16320, 23962,31604, 39246, 46888, 54530Pasotuxizumab_HeavyChain_LightChain_HeavyChain_Light 1037 8679, 16321,23963, 31605, 39247, 46889, 54531 Chain Pasotuxizumab_HeavyChain1 10388680, 16322, 23964, 31606, 39248, 46890, 54532 Pasotuxizumab_HeavyChain21039 8681, 16323, 23965, 31607, 39249, 46891, 54533Pasotuxizumab_LightChain1 1040 8682, 16324, 23966, 31608, 39250, 46892,54534 Pasotuxizumab_LightChain2 1041 8683, 16325, 23967, 31609, 39251,46893, 54535 Placulumab_HeavyChain 1042 8684, 16326, 23968, 31610,39252, 46894, 54536 Porgaviximab_HeavyChain 1043 8685, 16327, 23969,31611, 39253, 46895, 54537 Porgaviximab_LightChain 1044 8686, 16328,23970, 31612, 39254, 46896, 54538 Prezalumab_HeavyChain 1045 8687,16329, 23971, 31613, 39255, 46897, 54539 Prezalumab_LightChain 10468688, 16330, 23972, 31614, 39256, 46898, 54540 Radretumab_HeavyChain1047 8689, 16331, 23973, 31615, 39257, 46899, 54541Radretumab_HeavyChain_LightChain 1048 8690, 16332, 23974, 31616, 39258,46900, 54542 Radretumab_LightChain 1049 8691, 16333, 23975, 31617,39259, 46901, 54543 Ranevetmab_HeavyChain1 1050 8692, 16334, 23976,31618, 39260, 46902, 54544 Ranevetmab_HeavyChain2 1051 8693, 16335,23977, 31619, 39261, 46903, 54545 Ranevetmab_LightChain 1052 8694,16336, 23978, 31620, 39262, 46904, 54546 Remtolumab_HeavyChain 10538695, 16337, 23979, 31621, 39263, 46905, 54547 Remtolumab_LightChain1054 8696, 16338, 23980, 31622, 39264, 46906, 54548Rosmantuzumab_HeavyChain 1055 8697, 16339, 23981, 31623, 39265, 46907,54549 Rosmantuzumab_LightChain 1056 8698, 16340, 23982, 31624, 39266,46908, 54550 Rozanolixizumab_HeavyChain 1057 8699, 16341, 23983, 31625,39267, 46909, 54551 Rozanolixizumab_LightChain 1058 8700, 16342, 23984,31626, 39268, 46910, 54552 Sapalizumab_HeavyChain 1059 8701, 16343,23985, 31627, 39269, 46911, 54553 Sapalizumab_LightChain 1060 8702,16344, 23986, 31628, 39270, 46912, 54554 Salicrelumab_HeavyChain 10618703, 16345, 23987, 31629, 39271, 46913, 54555 Salicrelumab_LightChain1062 8704, 16346, 23988, 31630, 39272, 46914, 54556Solitomab_HeavyChain1 1063 8705, 16347, 23989, 31631, 39273, 46915,54557 Solitomab_HeavyChain2 1064 8706, 16348, 23990, 31632, 39274,46916, 54558 Solitomab_LightChain_HeavyChain_HeavyChain_LightChain 10658707, 16349, 23991, 31633, 39275, 46917, 54559 Solitomab_LightChain11066 8708, 16350, 23992, 31634, 39276, 46918, 54560Solitomab_LightChain2 1067 8709, 16351, 23993, 31635, 39277, 46919,54561 Suptavumab_HeavyChain2 1068 8710, 16352, 23994, 31636, 39278,46920, 54562 Suvratoxumab_HeavyChain 1069 8711, 16353, 23995, 31637,39279, 46921, 54563 Suvratoxumab_LightChain 1070 8712, 16354, 23996,31638, 39280, 46922, 54564 Tadocizumab_LightChain 1071 8713, 16355,23997, 31639, 39281, 46923, 54565 Tanezumab_HeavyChain 1072 8714, 16356,23998, 31640, 39282, 46924, 54566 Tanezumab_LightChain 1073 8715, 16357,23999, 31641, 39283, 46925, 54567 Tavolixizumab_HeavyChain 1074 8716,16358, 24000, 31642, 39284, 46926, 54568 Tavolixizumab_LightChain 10758717, 16359, 24001, 31643, 39285, 46927, 54569 Telisotuzumab_HeavyChain1076 8718, 16360, 24002, 31644, 39286, 46928, 54570Telisotuzumab_LightChain 1077 8719, 16361, 24003, 31645, 39287, 46929,54571 Telisotuzumab_vadotin_HeavyChain 1078 8720, 16362, 24004, 31646,39288, 46930, 54572 Telisotuzumab_vadotin_LightChain 1079 8721, 16363,24005, 31647, 39289, 46931, 54573 Timigutuzumab_HeavyChain 1080 8722,16364, 24006, 31648, 39290, 46932, 54574 Timigutuzumab_LightChain 10818723, 16365, 24007, 31649, 39291, 46933, 54575 Timolumab_HeavyChain 10828724, 16366, 24008, 31650, 39292, 46934, 54576 Timolumab_LightChain 10838725, 16367, 24009, 31651, 39293, 46935, 54577 Tomuzotuximab_HeavyChain1084 8726, 16368, 24010, 31652, 39294, 46936, 54578Tomuzotuximab_LightChain 1085 8727, 16369, 24011, 31653, 39295, 46937,54579 Trastuzumab_duocarmazine_HeavyChain 1086 8728, 16370, 24012,31654, 39296, 46938, 54580 Trastuzumab_duocarmazine_LightChain 10878729, 16371, 24013, 31655, 39297, 46939, 54581 Varisacumab_HeavyChain1088 8730, 16372, 24014, 31656, 39298, 46940, 54582Varisacumab_LightChain 1089 8731, 16373, 24015, 31657, 39299, 46941,54583 Vunakizumab_HeavyChain 1090 8732, 16374, 24016, 31658, 39300,46942, 54584 Vunakizumab_LightChain 1091 8733, 16375, 24017, 31659,39301, 46943, 54585 Xentuzumab_HeavyChain 1092 8734, 16376, 24018,31660, 39302, 46944, 54586 Xentuzumab_LightChain 1093 8735, 16377,24019, 31661, 39303, 46945, 54587 anti-rabies_S057_LightChain 1094 8736,16378, 24020, 31662, 39304, 46946, 54588 anti-rabies_S057_HeavyChain1095 8737, 16379, 24021, 31663, 39305, 46947, 54589anti-rabies_S0JB_LightChain 1096 8738, 16380, 24022, 31664, 39306,46948, 54590 anti-rabies_S0JB_HeavyChain 1097 8739, 16381, 24023, 31665,39307, 46949, 54591 anti-rabies_S0JA_LightChain 1098 8740, 16382, 24024,31666, 39308, 46950, 54592 anti-rabies_S0JA_HeavyChain 1099 8741, 16383,24025, 31667, 39309, 46951, 54593 anti-rabies_LightChain 1100 8742,16384, 24026, 31668, 39310, 46952, 54594 anti-rabies_HeavyChain 11018743, 16385, 24027, 31669, 39311, 46953, 54595 anti-rabies_LightChain1102 8744, 16386, 24028, 31670, 39312, 46954, 54596anti-rabies_HeavyChain 1103 8745, 16387, 24029, 31671, 39313, 46955,54597 anti-RSV_5ITB_LightChain 1104 8746, 16388, 24030, 31672, 39314,46956, 54598 anti-RSV_5ITB_HeavyChain 1105 8747, 16389, 24031, 31673,39315, 46957, 54599 anti-alpha-toxin_4U6V_LightChain 1106 8748, 16390,24032, 31674, 39316, 46958, 54600 anti-alpha-toxin_4U6V_HeavyChain 11078749, 16391, 24033, 31675, 39317, 46959, 54601anti-alpha-toxin_4U6V_Chain-A 1108 8750, 16392, 24034, 31676, 39318,46960, 54602 anti-alpha-toxin_4U6V_Chain-B 1109 8751, 16393, 24035,31677, 39319, 46961, 54603 anti-lsdB_5D1Q_Chain-A 1110 8752, 16394,24036, 31678, 39320, 46962, 54604 anti-lsdB_5D1Q_Chain-B 1111 8753,16395, 24037, 31679, 39321, 46963, 54605 anti-lsdB_5D1Q_Chain-C 11128754, 16396, 24038, 31680, 39322, 46964, 54606 anti-lsdB_5D1Q_Chain-D1113 8755, 16397, 24039, 31681, 39323, 46965, 54607anti-lsdB_5D1Q_Chain-E 1114 8756, 16398, 24040, 31682, 39324, 46966,54608 anti-lsdB_5D1Q_Chain-A 1115 8757, 16399, 24041, 31683, 39325,46967, 54609 anti-lsdB_5D1X_Chain-B 1116 8758, 16400, 24042, 31684,39326, 46968, 54610 anti-lsdB_5D1X_Chain-C 1117 8759, 16401, 24043,31685, 39327, 46969, 54611 anti-lsdB_5D1X_Chain-D 1118 8760, 16402,24044, 31686, 39328, 46970, 54612 anti-lsdB_5D1X_Chain-E 1119 8761,16403, 24045, 31687, 39329, 46971, 54613 anti-lsdB_5D1Z_Chain-B 11208762, 16404, 24046, 31688, 39330, 46972, 54614 anti-lsdB_5D1Z_Chain-C1121 8763, 16405, 24047, 31689, 39331, 46973, 54615anti-lsdB_5D1Z_Chain-D 1122 8764, 16406, 24048, 31690, 39332, 46974,54616 anti-lsdB_5D1Z_Chain-F 1123 8765, 16407, 24049, 31691, 39333,46975, 54617 anti-lsdB_5D1Z_Chain-G 1124 8766, 16408, 24050, 31692,39334, 46976, 54618 anti-lsdB_5D1Z_HeavyChain 1125 8767, 16409, 24051,31693, 39335, 46977, 54619 anti-lsdB_5D1Z_Chain-1 1126 8768, 16410,24052, 31694, 39336, 46978, 54620 anti-HIV_b12_LightChain 1127 8769,16411, 24053, 31695, 39337, 46979, 54621 anti-HIV_b12_HeavyChain 11288770, 16412, 24054, 31696, 39338, 46980, 54622 anti-HIV_2GI2_LightChain1129 8771, 16413, 24055, 31697, 39339, 46981, 54623anti-HIV_2GI2_HeavyChain 1130 8772, 16414, 24056, 31698, 39340, 46982,54624 anti-HIV_4E10_LightChain 1131 8773, 16415, 24057, 31699, 39341,46983, 54625 anti-HIV_4E10_HeavyChain 1132 8774, 16416, 24058, 31700,39342, 46984, 54626 anti-HIV_VRC01_LightChain 1133 8775, 16417, 24059,31701, 39343, 46985, 54627 anti-HIV_VRC01_HeavyChain 1134 8776, 16418,24060, 31702, 39344, 46986, 54628 anti-HIV_PG9_LightChain 1135 8777,16419, 24061, 31703, 39345, 46987, 54629 anti-HIV_PG9_HeavyChain 11368778, 16420, 24062, 31704, 39346, 46988, 54630 anti-HIV_VRC07_LightChain1137 8779, 16421, 24063, 31705, 39347, 46989, 54631anti-HIV_VRC07_HeavyChain 1138 8780, 16422, 24064, 31706, 39348, 46990,54632 anti-HIV_3BNC1I7_LightChain 1139 8781, 16423, 24065, 31707, 39349,46991, 54633 anti-HIV_3BNC1I7_HeavyChain 1140 8782, 16424, 24066, 31708,39350, 46992, 54634 anti-HIV_10-1074_LightChain 1141 8783, 16425, 24067,31709, 39351, 46993, 54635 anti-HIV_10-1074_HeavyChain 1142 8784, 16426,24068, 31710, 39352, 46994, 54636 anti-HIV_PGT12I_LightChain 1143 8785,16427, 24069, 31711, 39353, 46995, 54637 anti-HIV_PGT12I_HeavyChain 11448786, 16428, 24070, 31712, 39354, 46996, 54638anti-HIV_PGDM1400_LightChain 1145 8787, 16429, 24071, 31713, 39355,46997, 54639 anti-HIV_PGDM1400_HeavyChain 1146 8788, 16430, 24072,31714, 39356, 46998, 54640 anti-HIV_N6_LightChain 1147 8789, 16431,24073, 31715, 39357, 46999, 54641 anti-HIV_N6_HeavyChain 1148 8790,16432, 24074, 31716, 39358, 47000, 54642 anti-HIV_N6_GChain 1149 8791,16433, 24075, 31717, 39359, 47001, 54643 anti-HIV_10E8_LightChain 11508792, 16434, 24076, 31718, 39360, 47002, 54644 anti-HIV_10E8_HeavyChain1151 8793, 16435, 24077, 31719, 39361, 47003, 54645anti-HIV_12A12_LightChain 1152 8794, 16436, 24078, 31720, 39362, 47004,54646 anti-HIV_12A12_HeavyChain 1153 8795, 16437, 24079, 31721, 39363,47005, 54647 anti-HIV_12A21_LightChain 1154 8796, 16438, 24080, 31722,39364, 47006, 54648 anti-HIV_12A21_HeavyChain 1155 8797, 16439, 24081,31723, 39365, 47007, 54649 anti-HIV_35022_LightChain 1156 8798, 16440,24082, 31724, 39366, 47008, 54650 anti-HIV_35022_HeavyChain 1157 8799,16441, 24083, 31725, 39367, 47009, 54651 anti-HIV_38C176_LightChain 11588800, 16442, 24084, 31726, 39368, 47010, 54652anti-HIV_38C176_HeavyChain 1159 8801, 16443, 24085, 31727, 39369, 47011,54653 anti-HIV_3BNC55_LightChain 1160 8802, 16444, 24086, 31728, 39370,47012, 54654 anti-HIV_3BNC55_HeavyChain 1161 8803, 16445, 24087, 31729,39371, 47013, 54655 anti-HIV_3BNC60_LightChain 1162 8804, 16446, 24088,31730, 39372, 47014, 54656 anti-HIV_3BNC60_HeavyChain 1163 8805, 16447,24089, 31731, 39373, 47015, 54657 anti-HIV_3BNC60_HeavyChain 1164 8806,16448, 24090, 31732, 39374, 47016, 54658 anti-HIV_447-520_LightChain1165 8807, 16449, 24091, 31733, 39375, 47017, 54659anti-HIV_447-520_HeavyChain 1166 8808, 16450, 24092, 31734, 39376,47018, 54660 anti-HIV_447-520_LightChain 1167 8809, 16451, 24093, 31735,39377, 47019, 54661 anti-HIV_447-520_HeavyChain 1168 8810, 16452, 24094,31736, 39378, 47020, 54662 anti-HIV_5H/I1-BMV-D5_LightChain 1169 8811,16453, 24095, 31737, 39379, 47021, 54663anti-HIV_5H/I1-BMV-D5_HeavyChain 1170 8812, 16454, 24096, 31738, 39380,47022, 54664 anti-HIV_5H/I1-BMV-D5_A-Chain 1171 8813, 16455, 24097,31739, 39381, 47023, 54665 anti-HIV_8ANC195_LightChain 1172 8814, 16456,24098, 31740, 39382, 47024, 54666 anti-HIV_8ANC195_HeavyChain 1173 8815,16457, 24099, 31741, 39383, 47025, 54667anti-HIV_CAP256-VRC26.01_LightChain 1174 8816, 16458, 24100, 31742,39384, 47026, 54668 anti-HIV_CAP256-VRC26.01_HeavyChain 1175 8817,16459, 24101, 31743, 39385, 47027, 54669anti-HIV_CAP256-VRC26.02_LightChain 1176 8818, 16460, 24102, 31744,39386, 47028, 54670 anti-HIV_CAP256-VRC26.02_HeavyChain 1177 8819,16461, 24103, 31745, 39387, 47029, 54671anti-HIV_CAP256-VRC26.03_LightChain 1178 8820, 16462, 24104, 31746,39388, 47030, 54672 anti-HIV_CAP256-VRC26.03_HeavyChain 1179 8821,16463, 24105, 31747, 39389, 47031, 54673anti-HIV_CAP256-VRC26.04_LightChain 1180 8822, 16464, 24106, 31748,39390, 47032, 54674 anti-HIV_CAP256-VRC26.04_HeavyChain 1181 8823,16465, 24107, 31749, 39391, 47033, 54675anti-HIV_CAP256-VRC26.05_LightChain 1182 8824, 16466, 24108, 31750,39392, 47034, 54676 anti-HIV_CAP256-VRC26.05_HeavyChain 1183 8825,16467, 24109, 31751, 39393, 47035, 54677anti-HIV_CAP256-VRC26.06_LightChain 1184 8826, 16468, 24110, 31752,39394, 47036, 54678 anti-HIV_CAP256-VRC26.06_HeavyChain 1185 8827,16469, 24111, 31753, 39395, 47037, 54679anti-HIV_CAP256-VRC26.07_LightChain 1186 8828, 16470, 24112, 31754,39396, 47038, 54680 anti-HIV_CAP256-VRC26.07_HeavyChain 1187 8829,16471, 24113, 31755, 39397, 47039, 54681anti-HIV_CAP256-VRC26.08_LightChain 1188 8830, 16472, 24114, 31756,39398, 47040, 54682 anti-HIV_CAP256-VRC26.08_HeavyChain 1189 8831,16473, 24115, 31757, 39399, 47041, 54683anti-HIV_CAP256-VRC26.09_LightChain 1190 8832, 16474, 24116, 31758,39400, 47042, 54684 anti-HIV_CAP256-VRC26.09_HeavyChain 1191 8833,16475, 24117, 31759, 39401, 47043, 54685anti-HIV_CAP256-VRC26.10_LightChain 1192 8834, 16476, 24118, 31760,39402, 47044, 54686 anti-HIV_CAP256-VRC26.10_HeavyChain 1193 8835,16477, 24119, 31761, 39403, 47045, 54687anti-HIV_CAP256-VRC26.11_LightChain 1194 8836, 16478, 24120, 31762,39404, 47046, 54688 anti-HIV_CAP256-VRC26.11_HeavyChain 1195 8837,16479, 24121, 31763, 39405, 47047, 54689anti-HIV_CAP256-VRC26.12_LightChain 1196 8838, 16480, 24122, 31764,39406, 47048, 54690 anti-HIV_CAP256-VRC26.12_HeavyChain 1197 8839,16481, 24123, 31765, 39407, 47049, 54691anti-HIV_CAP256-VRC26.11_LightChain 1198 8840, 16482, 24124, 31766,39408, 47050, 54692 anti-HIV_CAP256-VRC26.11_HeavyChain 1199 8841,16483, 24125, 31767, 39409, 47051, 54693anti-HIV_CAP256-VRC26.12_LightChain 1200 8842, 16484, 24126, 31768,39410, 47052, 54694 anti-HIV_CAP256-VRC26.12_HeavyChain 1201 8843,16485, 24127, 31769, 39411, 47053, 54695anti-HIV_CAP256-VRC26.UCA_LightChain 1202 8844, 16486, 24128, 31770,39412, 47054, 54696 anti-HIV_CAP256-VRC26.UCA_HeavyChain 1203 8845,16487, 24129, 31771, 39413, 47055, 54697 anti-HIV_CH01_LightChain 12048846, 16488, 24130, 31772, 39414, 47056, 54698 anti-HIV_CH01_HeavyChain1205 8847, 16489, 24131, 31773, 39415, 47057, 54699anti-HIV_CH02_LightChain 1206 8848, 16490, 24132, 31774, 39416, 47058,54700 anti-HIV_CH02_HeavyChain 1207 8849, 16491, 24133, 31775, 39417,47059, 54701 anti-HIV_CH03_LightChain 1208 8850, 16492, 24134, 31776,39418, 47060, 54702 anti-HIV_CH03_HeavyChain 1209 8851, 16493, 24135,31777, 39419, 47061, 54703 anti-HIV_CH04_LightChain 1210 8852, 16494,24136, 31778, 39420, 47062, 54704 anti-HIV_CH04_HeavyChain 1211 8853,16495, 24137, 31779, 39421, 47063, 54705 anti-HIV_CH103_LightChain 12128854, 16496, 24138, 31780, 39422, 47064, 54706 anti-HIV_CH103_HeavyChain1213 8855, 16497, 24139, 31781, 39423, 47065, 54707anti-HIV_M66.6_LightChain 1214 8856, 16498, 24140, 31782, 39424, 47066,54708 anti-HIV_M66.6_HeavyChain 1215 8857, 16499, 24141, 31783, 39425,47067, 54709 anti-HIV_NIH45-46_LightChain 1216 8858, 16500, 24142,31784, 39426, 47068, 54710 anti-HIV_NIH45-46_HeavyChain 1217 8859,16501, 24143, 31785, 39427, 47069, 54711 anti-HIV_PG16_LightChain 12188860, 16502, 24144, 31786, 39428, 47070, 54712 anti-HIV_PG16_HeavyChain1219 8861, 16503, 24145, 31787, 39429, 47071, 54713anti-HIV_PGT122_LightChain 1220 8862, 16504, 24146, 31788, 39430, 47072,54714 anti-HIV_PGT122_HeavyChain 1221 8863, 16505, 24147, 31789, 39431,47073, 54715 anti-HIV_PGT123_LightChain 1222 8864, 16506, 24148, 31790,39432, 47074, 54716 anti-HIV_PGT123_HeavyChain 1223 8865, 16507, 24149,31791, 39433, 47075, 54717 anti-HIV_PGT125_LightChain 1224 8866, 16508,24150, 31792, 39434, 47076, 54718 anti-HIV_PGT125_HeavyChain 1225 8867,16509, 24151, 31793, 39435, 47077, 54719 anti-HIV_PGT126_LightChain 12268868, 16510, 24152, 31794, 39436, 47078, 54720anti-HIV_PGT126_HeavyChain 1227 8869, 16511, 24153, 31795, 39437, 47079,54721 anti-HIV_PGT127_LightChain 1228 8870, 16512, 24154, 31796, 39438,47080, 54722 anti-HIV_PGT127_HeavyChain 1229 8871, 16513, 24155, 31797,39439, 47081, 54723 anti-HIV_PGT128_LightChain 1230 8872, 16514, 24156,31798, 39440, 47082, 54724 anti-HIV_PGT128_HeavyChain 1231 8873, 16515,24157, 31799, 39441, 47083, 54725 anti-HIV_PGT130_LightChain 1232 8874,16516, 24158, 31800, 39442, 47084, 54726 anti-HIV_PGT130_HeavyChain 12338875, 16517, 24159, 31801, 39443, 47085, 54727anti-HIV_PGT131_LightChain 1234 8876, 16518, 24160, 31802, 39444, 47086,54728 anti-HIV_PGT131_HeavyChain 1235 8877, 16519, 24161, 31803, 39445,47087, 54729 anti-HIV_PGT135_LightChain 1236 8878, 16520, 24162, 31804,39446, 47088, 54730 anti-HIV_PGT135_HeavyChain 1237 8879, 16521, 24163,31805, 39447, 47089, 54731 anti-HIV_PGT136_LightChain 1238 8880, 16522,24164, 31806, 39448, 47090, 54732 anti-HIV_PGT136_HeavyChain 1239 8881,16523, 24165, 31807, 39449, 47091, 54733 anti-HIV_PGT137_LightChain 12408882, 16524, 24166, 31808, 39450, 47092, 54734anti-HIV_PGT137_HeavyChain 1241 8883, 16525, 24167, 31809, 39451, 47093,54735 anti-HIV_PGT141_LightChain 1242 8884, 16526, 24168, 31810, 39452,47094, 54736 anti-HIV_PGT141_HeavyChain 1243 8885, 16527, 24169, 31811,39453, 47095, 54737 anti-HIV_PGT142_LightChain 1244 8886, 16528, 24170,31812, 39454, 47096, 54738 anti-HIV_PGT142_HeavyChain 1245 8887, 16529,24171, 31813, 39455, 47097, 54739 anti-HIV_PGT143_LightChain 1246 8888,16530, 24172, 31814, 39456, 47098, 54740 anti-HIV_PGT143_HeavyChain 12478889, 16531, 24173, 31815, 39457, 47099, 54741anti-HIV_PGT144_LightChain 1248 8890, 16532, 24174, 31816, 39458, 47100,54742 anti-HIV_PGT144_HeavyChain 1249 8891, 16533, 24175, 31817, 39459,47101, 54743 anti-HIV_PGT145_LightChain 1250 8892, 16534, 24176, 31818,39460, 47102, 54744 anti-HIV_PGT145_HeavyChain 1251 8893, 16535, 24177,31819, 39461, 47103, 54745 anti-HIV_PGT151_LightChain 1252 8894, 16536,24178, 31820, 39462, 47104, 54746 anti-HIV_PGT151_HeavyChain 1253 8895,16537, 24179, 31821, 39463, 47105, 54747 anti-HIV_PGT152_LightChain 12548896, 16538, 24180, 31822, 39464, 47106, 54748anti-HIV_PGT152_HeavyChain 1255 8897, 16539, 24181, 31823, 39465, 47107,54749 anti-HIV_VRC-CH30_LightChain 1256 8898, 16540, 24182, 31824,39466, 47108, 54750 anti-HIV_VRC-CH30_HeavyChain 1257 8899, 16541,24183, 31825, 39467, 47109, 54751 anti-HIV_VRC-CH31_LightChain 12588900, 16542, 24184, 31826, 39468, 47110, 54752anti-HIV_VRC-CH31_HeavyChain 1259 8901, 16543, 24185, 31827, 39469,47111, 54753 anti-HIV_VRC-CH32_LightChain 1250 8902, 16544, 24186,31828, 39470, 47112, 54754 anti-HIV_VRC-CH32_HeavyChain 1251 8903,16545, 24187, 31829, 39471, 47113, 54755 anti-HIV_VRC-CH33_LightChain1252 8904, 16546, 24188, 31830, 39472, 47114, 54756anti-HIV_VRC-CH33_HeavyChain 1253 8905, 16547, 24189, 31831, 39473,47115, 54757 anti-HIV_VRC-CH34_LightChain 1254 8906, 16548, 24190,31832, 39474, 47116, 54758 anti-HIV_VRC-CH34_HeavyChain 1255 8907,16549, 24191, 31833, 39475, 47117, 54759 anti-HIV_VRC-PG04_LightChain1256 8908, 16550, 24192, 31834, 39476, 47118, 54760anti-HIV_VRC-PG04_HeavyChain 1257 8909, 16551, 24193, 31835, 39477,47119, 54761 anti-HIV_VRC-PG04b_LightChain 1258 8910, 16552, 24194,31836, 39478, 47120, 54762 anti-HIV_VRC-PG04b_HeavyChain 1259 8911,16553, 24195, 31837, 39479, 47121, 54763 anti-HIV_VRC-PG20_LightChain1270 8912, 16554, 24196, 31838, 39480, 47122, 54764anti-HIV_VRC-PG20_HeavyChain 1271 8913, 16555, 24197, 31839, 39481,47123, 54765 anti-HIV_VRC-PG20_G-Chain 1272 8914, 16556, 24198, 31840,39482, 47124, 54766 anti-HIV_VRC02_LightChain 1273 8915, 16557, 24199,31841, 39483, 47125, 54767 anti-HIV_VRC02_HeavyChain 1274 8916, 16558,24200, 31842, 39484, 47126, 54768 anti-HIV_VRC03_LightChain 1275 8917,16559, 24201, 31843, 39485, 47127, 54769 anti-HIV_VRC03_HeavyChain 12768918, 16560, 24202, 31844, 39486, 47128, 54770 anti-HIV_VRC23_LightChain1277 8919, 16561, 24203, 31845, 39487, 47129, 54771anti-HIV_VRC23_HeavyChain 1278 8920, 16562, 24204, 31846, 39488, 47130,54772 anti-HIV_VRC23_G-Chain 1279 8921, 16563, 24205, 31847, 39489,47131, 54773 anti-HIV_5CCK_LightChain 1280 8922, 16564, 24206, 31848,39490, 47132, 54774 anti-HIV_5CCK_HeavyChain 1281 8923, 16565, 24207,31849, 39491, 47133, 54775 anti-HIV_5AWN_LightChain 1282 8924, 16566,24208, 31850, 39492, 47134, 54776 anti-HIV_5AWN_HeavyChain 1283 8925,16567, 24209, 31851, 39493, 47135, 54777 anti-HIV_3QEG_LightChain 12848926, 16568, 24210, 31852, 39494, 47136, 54778 anti-HIV_3QEG_HeavyChain1285 8927, 16569, 24211, 31853, 39495, 47137, 54779anti-HIV_INOX_K-Chain 1286 8928, 16570, 24212, 31854, 39496, 47138,54780 anti-HIV_INOX_M-Chain 1287 8929, 16571, 24213, 31855, 39497,47139, 54781 anti-HIV_3QEH_HeavyChain 1288 8930, 16572, 24214, 31856,39498, 47140, 54782 anti-HIV_3QEH_G-Chain 1289 8931, 16573, 24215,31857, 39499, 47141, 54783 anti-HIV_2BIH_HeavyChain 1290 8932, 16574,24216, 31858, 39500, 47142, 54784 anti-HIV_2BIH_LightChain 1291 8933,16575, 24217, 31859, 39501, 47143, 54785 anti-HIV_3TNM_B-Chain 12928934, 16576, 24218, 31860, 39502, 47144, 54786 anti-HIV_3TNM_A-Chain1293 8935, 16577, 24219, 31861, 39503, 47145, 54787anti-HIV_3UJJ_HeavyChain 1294 8936, 16578, 24220, 31862, 39504, 47146,54788 anti-HIV_3UJJ_LightChain 1295 8937, 16579, 24221, 31863, 39505,47147, 54789 anti-HIV_3UJI_HeavyChain 1296 8938, 16580, 24222, 31864,39506, 47148, 54790 anti-HIV_3UJI_LightChain 1297 8939, 16581, 24223,31865, 39507, 47149, 54791 anti-HIV_2QSC_HeavyChain 1298 8940, 16582,24224, 31866, 39508, 47150, 54792 anti-HIV_2QSC_LightChain 1299 8941,16583, 24225, 31867, 39509, 47151, 54793 anti-HIV_3MLZ_HeavyChain 13008942, 16584, 24226, 31868, 39510, 47152, 54794 anti-HIV_3MLZ_LightChain1301 8943, 16585, 24227, 31869, 39511, 47153, 54795anti-HIV_3MLX_I-Chain 1302 8944, 16586, 24228, 31870, 39512, 47154,54796 anti-HIV_3MLX_M-Chain 1303 8945, 16587, 24229, 31871, 39513,47155, 54797 anti-HIV_3MLW_I-Chain 1304 8946, 16588, 24230, 31872,39514, 47156, 54798 anti-HIV_3MLW_M-Chain 1305 8947, 16589, 24231,31873, 39515, 47157, 54799 anti-HIV_3MLV_N-Chain 1306 8948, 16590,24232, 31874, 39516, 47158, 54800 anti-HIV_3MLV_M-Chain 1307 8949,16591, 24233, 31875, 39517, 47159, 54801 anti-HIV_3MLU_LightChain 13088950, 16592, 24234, 31876, 39518, 47160, 54802 anti-HIV_3MLT_G-Chain1309 8951, 16593, 24235, 31877, 39519, 47161, 54803anti-HIV_3G01_HeavyChain 1310 8952, 16594, 24236, 31878, 39520, 47162,54804 anti-HIV_3G01_LightChain 1311 8953, 16595, 24237, 31879, 39521,47163, 54805 anti-HIV_4XCY_J-Chain 1312 8954, 16596, 24238, 31880,39522, 47164, 54806 anti-HIV_4XCY_K-Chain 1313 8955, 16597, 24239,31881, 39523, 47165, 54807 anti-HIV_4YBL_C-Chain 1314 8956, 16598,24240, 31882, 39524, 47166, 54808 anti-HIV_4YBL_B-Chain 1315 8957,16599, 24241, 31883, 39525, 47167, 54809 anti-HIV_4R4N_X-Chain 13168958, 16600, 24242, 31884, 39526, 47168, 54810 anti-HIV_4R4B_F-Chain1317 8959, 16601, 24243, 31885, 39527, 47169, 54811anti-HIV_3JUY_D-Chain 1318 8960, 16602, 24244, 31886, 39528, 47170,54812 anti-HIV_4KG5_HeavyChain 1319 8961, 16603, 24245, 31887, 39529,47171, 54813 anti-HIV_4KG5_LightChain 1320 8962, 16604, 24246, 31888,39530, 47172, 54814 anti-HIV-1_LightChain 1321 8963, 16605, 24247,31889, 39531, 47173, 54815 anti-HIV-1_LightChain 1322 8964, 16606,24248, 31890, 39532, 47174, 54816 anti-HIV-1_LightChain 1323 8965,16607, 24249, 31891, 39533, 47175, 54817 anti-HIV-1_LightChain 13248966, 16608, 24250, 31892, 39534, 47176, 54818 anti-HIV-1_LightChain1325 8967, 16609, 24251, 31893, 39535, 47177, 54819anti-HIV-1_LightChain 1326 8968, 16610, 24252, 31894, 39536, 47178,54820 anti-HIV-1_HeavyChain 1327 8969, 16611, 24253, 31895, 39537,47179, 54821 anti-HIV-1_HeavyChain 1328 8970, 16612, 24254, 31896,39538, 47180, 54822 anti-HIV-1_HeavyChain 1329 8971, 16613, 24255,31897, 39539, 47181, 54823 anti-HIV-1_HeavyChain 1330 8972, 16614,24256, 31898, 39540, 47182, 54824 anti-HIV-1_HeavyChain 1331 8973,16615, 24257, 31899, 39541, 47183, 54825 anti-HIV-1_HeavyChain 13328974, 16616, 24258, 31900, 39542, 47184, 54826 anti-HIV-1_HeavyChain1333 8975, 16617, 24259, 31901, 39543, 47185, 54827anti-HIV-1_HeavyChain 1334 8976, 16618, 24260, 31902, 39544, 47186,54828 anti-HIV-1_HeavyChain 1335 8977, 16619, 24261, 31903, 39545,47187, 54829 anti-HIV-1_HeavyChain 1336 8978, 16620, 24262, 31904,39546, 47188, 54830 anti-HIV-1_LightChain 1337 8979, 16621, 24263,31905, 39547, 47189, 54831 anti-HIV-1_LightChain 1338 8980, 16622,24264, 31906, 39548, 47190, 54832 anti-HIV-1_LightChain 1339 8981,16623, 24265, 31907, 39549, 47191, 54833 anti-HIV-1_LightChain 13408982, 16624, 24266, 31908, 39550, 47192, 54834 anti-HIV-1_LightChain1341 8983, 16625, 24267, 31909, 39551, 47193, 54835anti-HIV-1_LightChain 1342 8984, 16626, 24268, 31910, 39552, 47194,54836 anti-HIV-1_LightChain 1343 8985, 16627, 24269, 31911, 39553,47195, 54837 anti-HIV-1_LightChain 1344 8986, 16628, 24270, 31912,39554, 47196, 54838 anti-HIV-1_HeavyChain 1345 8987, 16629, 24271,31913, 39555, 47197, 54839 anti-HIV-1_HeavyChain 1346 8988, 16630,24272, 31914, 39556, 47198, 54840 anti-HIV-1_HeavyChain 1347 8989,16631, 24273, 31915, 39557, 47199, 54841 anti-HIV-1_HeavyChain 13488990, 16632, 24274, 31916, 39558, 47200, 54842 anti-HIV-1_HeavyChain1349 8991, 16633, 24275, 31917, 39559, 47201, 54843anti-HIV-1_HeavyChain 1350 8992, 16634, 24276, 31918, 39560, 47202,54844 anti-HIV-1_HeavyChain 1351 8993, 16635, 24277, 31919, 39561,47203, 54845 anti-HIV-1_HeavyChain 1352 8994, 16636, 24278, 31920,39562, 47204, 54846 anti-HIV_V3_HeavyChain 1353 8995, 16637, 24279,31921, 39563, 47205, 54847 anti-HIV_V3_HeavyChain 1354 8996, 16638,24280, 31922, 39564, 47206, 54848 anti-HIV_V3_HeavyChain 1355 8997,16639, 24281, 31923, 39565, 47207, 54849 anti-HIV_V3_HeavyChain 13568998, 16640, 24282, 31924, 39566, 47208, 54850 anti-HIV_V3_HeavyChain1357 8999, 16641, 24283, 31925, 39567, 47209, 54851anti-HIV_V3_HeavyChain 1358 9000, 16642, 24284, 31926, 39568, 47210,54852 anti-HIV_V3_HeavyChain 1359 9001, 16643, 24285, 31927, 39569,47211, 54853 anti-HIV_V3_HeavyChain 1360 9002, 16644, 24286, 31928,39570, 47212, 54854 anti-HIV_V3_HeavyChain 1361 9003, 16645, 24287,31929, 39571, 47213, 54855 anti-HIV_V3_HeavyChain 1362 9004, 16646,24288, 31930, 39572, 47214, 54856 anti-HIV_V3_HeavyChain 1363 9005,16647, 24289, 31931, 39573, 47215, 54857 anti-HIV_V3_HeavyChain 13649006, 16648, 24290, 31932, 39574, 47216, 54858 anti-HIV_CD4bs_HeavyChain1365 9007, 16649, 24291, 31933, 39575, 47217, 54859anti-HIV_CD4bs_HeavyChain 1366 9008, 16650, 24292, 31934, 39576, 47218,54860 anti-HIV_CD4bs_HeavyChain 1367 9009, 16651, 24293, 31935, 39577,47219, 54861 anti-HIV_CD4bs_HeavyChain 1368 9010, 16652, 24294, 31936,39578, 47220, 54862 anti-HIV_CD4bs_HeavyChain 1369 9011, 16653, 24295,31937, 39579, 47221, 54863 anti-HIV_CD4bs_HeavyChain 1370 9012, 16654,24296, 31938, 39580, 47222, 54864 anti-HIV_CD4bs_HeavyChain 1371 9013,16655, 24297, 31939, 39581, 47223, 54865 anti-HIV_CD4bs_HeavyChain 13729014, 16656, 24298, 31940, 39582, 47224, 54866 anti-HIV_CD4bs_HeavyChain1373 9015, 16657, 24299, 31941, 39583, 47225, 54867anti-HIV_CD4bs_HeavyChain 1374 9016, 16658, 24300, 31942, 39584, 47226,54868 anti-HIV_V2_HeavyChain 1375 9017, 16659, 24301, 31943, 39585,47227, 54869 anti-HIV_V2_HeavyChain 1376 9018, 16660, 24302, 31944,39586, 47228, 54870 anti-HIV_V2_HeavyChain 1377 9019, 16661, 24303,31945, 39587, 47229, 54871 anti-HIV_V2_HeavyChain 1378 9020, 16662,24304, 31946, 39588, 47230, 54872 anti-HIV_V2_HeavyChain 1379 9021,16663, 24305, 31947, 39589, 47231, 54873 anti-HIV_V2_HeavyChain 13809022, 16664, 24306, 31948, 39590, 47232, 54874 anti-HIV_V3_LightChain1381 9023, 16665, 24307, 31949, 39591, 47233, 54875anti-HIV_V3_LightChain 1382 9024, 16666, 24308, 31950, 39592, 47234,54876 anti-HIV_V3_LightChain 1383 9025, 16667, 24309, 31951, 39593,47235, 54877 anti-HIV_V3_LightChain 1384 9026, 16668, 24310, 31952,39594, 47236, 54878 anti-HIV_V3_LightChain 1385 9027, 16669, 24311,31953, 39595, 47237, 54879 anti-HIV_V3_LightChain 1386 9028, 16670,24312, 31954, 39596, 47238, 54880 anti-HIV_V3_LightChain 1387 9029,16671, 24313, 31955, 39597, 47239, 54881 anti-HIV_V3_LightChain 13889030, 16672, 24314, 31956, 39598, 47240, 54882 anti-HIV_V3_LightChain1389 9031, 16673, 24315, 31957, 39599, 47241, 54883anti-HIV_V3_LightChain 1390 9032, 16674, 24316, 31958, 39600, 47242,54884 anti-HIV_V3_LightChain 1391 9033, 16675, 24317, 31959, 39601,47243, 54885 anti-HIV_V3_LightChain 1392 9034, 16676, 24318, 31960,39602, 47244, 54886 anti-HIV_V3_LightChain 1393 9035, 16677, 24319,31961, 39603, 47245, 54887 anti-HIV_V3_LightChain 1394 9036, 16678,24320, 31962, 39604, 47246, 54888 anti-HIV_V3_LightChain 1395 9037,16679, 24321, 31963, 39605, 47247, 54889 anti-HIV_V3_LightChain 13969038, 16680, 24322, 31964, 39606, 47248, 54890 anti-HIV_V3_LightChain1397 9039, 16681, 24323, 31965, 39607, 47249, 54891anti-HIV_V3_LightChain 1398 9040, 16682, 24324, 31966, 39608, 47250,54892 anti-HIV_V3_LightChain 1399 9041, 16683, 24325, 31967, 39609,47251, 54893 anti-HIV_V3_LightChain 1400 9042, 16684, 24326, 31968,39610, 47252, 54894 anti-HIV_V3_LightChain 1401 9043, 16685, 24327,31969, 39611, 47253, 54895 anti-HIV_V3_LightChain 1402 9044, 16686,24328, 31970, 39612, 47254, 54896 anti-HIV_V3_LightChain 1403 9045,16687, 24329, 31971, 39613, 47255, 54897 anti-HIV_V3_LightChain 14049046, 16688, 24330, 31972, 39614, 47256, 54898 anti-HIV_V3_LightChain1405 9047, 16689, 24331, 31973, 39615, 47257, 54899anti-HIV_V3_LightChain 1406 9048, 16690, 24332, 31974, 39616, 47258,54900 anti-HIV_V3_LightChain 1407 9049, 16691, 24333, 31975, 39617,47259, 54901 anti-HIV_V3_LightChain 1408 9050, 16692, 24334, 31976,39618, 47260, 54902 anti-HIV_V3_LightChain 1409 9051, 16693, 24335,31977, 39619, 47261, 54903 anti-HIV_V3_LightChain 1410 9052, 16694,24336, 31978, 39620, 47262, 54904 anti-HIV_CD4bs_LightChain 1411 9053,16695, 24337, 31979, 39621, 47263, 54905 anti-HIV_CD4bs_LightChain 14129054, 16696, 24338, 31980, 39622, 47264, 54906 anti-HIV_CD4bs_LightChain1413 9055, 16697, 24339, 31981, 39623, 47265, 54907anti-HIV_CD4bs_LightChain 1414 9056, 16698, 24340, 31982, 39624, 47266,54908 anti-HIV_CD4bs_LightChain 1415 9057, 16699, 24341, 31983, 39625,47267, 54909 anti-HIV_CD4bs_LightChain 1416 9058, 16700, 24342, 31984,39626, 47268, 54910 anti-HIV_CD4bs_LightChain 1417 9059, 16701, 24343,31985, 39627, 47269, 54911 anti-HIV_CD4bs_LightChain 1418 9060, 16702,24344, 31986, 39628, 47270, 54912 anti-HIV_CD4bs_LightChain 1419 9061,16703, 24345, 31987, 39629, 47271, 54913 anti-HIV_CD4bs_LightChain 14209062, 16704, 24346, 31988, 39630, 47272, 54914 anti-HIV_V2_LightChain1421 9063, 16705, 24347, 31989, 39631, 47273, 54915anti-HIV_V2_LightChain 1422 9064, 16706, 24348, 31990, 39632, 47274,54916 anti-HIV_V2_LightChain 1423 9065, 16707, 24349, 31991, 39633,47275, 54917 anti-HIV_V2_LightChain 1424 9066, 16708, 24350, 31992,39634, 47276, 54918 anti-HIV_V2_LightChain 1425 9067, 16709, 24351,31993, 39635, 47277, 54919 anti-HIV_V2_LightChain 1426 9068, 16710,24352, 31994, 39636, 47278, 54920 anti-HIV_10E8 1427 9069, 16711, 24353,31995, 39637, 47279, 54921 anti-HIV_10E8 1428 9070, 16712, 24354, 31996,39638, 47280, 54922 anti-HIV_10E8 1429 9071, 16713, 24355, 31997, 39639,47281, 54923 anti-HIV_10E8 1430 9072, 16714, 24356, 31998, 39640, 47282,54924 anti-HIV_10E8 1431 9073, 16715, 24357, 31999, 39641, 47283, 54925anti-HIV_10E8 1432 9074, 16716, 24358, 32000, 39642, 47284, 54926anti-HIV_10E8 1433 9075, 16717, 24359, 32001, 39643, 47285, 54927anti-HIV_10E8 1434 9076, 16718, 24360, 32002, 39644, 47286, 54928anti-HIV_10E8 1435 9077, 16719, 24361, 32003, 39645, 47287, 54929anti-HIV_10E8 1436 9078, 16720, 24362, 32004, 39646, 47288, 54930anti-HIV_10E8 1437 9079, 16721, 24363, 32005, 39647, 47289, 54931anti-HIV_10E8 1438 9080, 16722, 24364, 32006, 39648, 47290, 54932anti-HIV_10E8 1439 9081, 16723, 24365, 32007, 39649, 47291, 54933anti-HIV_10E8 1440 9082, 16724, 24366, 32008, 39650, 47292, 54934anti-HIV_10E8 1441 9083, 16725, 24367, 32009, 39651, 47293, 54935anti-HIV_10E8 1442 9084, 16726, 24368, 32010, 39652, 47294, 54936anti-HIV_10E8 1443 9085, 16727, 24369, 32011, 39653, 47295, 54937anti-HIV_10E8 1444 9086, 16728, 24370, 32012, 39654, 47296, 54938anti-HIV_10E8 1445 9087, 16729, 24371, 32013, 39655, 47297, 54939anti-HIV_10E8 1446 9088, 16730, 24372, 32014, 39656, 47298, 54940anti-HIV_10E8 1447 9089, 16731, 24373, 32015, 39657, 47299, 54941anti-HIV_10E8 1448 9090, 16732, 24374, 32016, 39658, 47300, 54942anti-HIV_10E8 1449 9091, 16733, 24375, 32017, 39659, 47301, 54943anti-HIV_10E8 1450 9092, 16734, 24376, 32018, 39660, 47302, 54944anti-HIV_10E8 1451 9093, 16735, 24377, 32019, 39661, 47303, 54945anti-HIV_10E8 1452 9094, 16736, 24378, 32020, 39662, 47304, 54946anti-HIV_10E8 1453 9095, 16737, 24379, 32021, 39663, 47305, 54947anti-HIV_10E8 1454 9096, 16738, 24380, 32022, 39664, 47306, 54948anti-HIV_10E8 1455 9097, 16739, 24381, 32023, 39665, 47307, 54949anti-HIV_10E8 1456 9098, 16740, 24382, 32024, 39666, 47308, 54950anti-HIV_10E8 1457 9099, 16741, 24383, 32025, 39667, 47309, 54951anti-HIV_10E8 1458 9100, 16742, 24384, 32026, 39668, 47310, 54952anti-HIV-1_LightChain 1459 9101, 16743, 24385, 32027, 39669, 47311,54953 anti-HIV-1_LightChain 1460 9102, 16744, 24386, 32028, 39670,47312, 54954 anti-HIV-1_LightChain 1461 9103, 16745, 24387, 32029,39671, 47313, 54955 anti-HIV-1_LightChain 1462 9104, 16746, 24388,32030, 39672, 47314, 54956 anti-HIV-1_LightChain 1463 9105, 16747,24389, 32031, 39673, 47315, 54957 anti-HIV-1_LightChain 1464 9106,16748, 24390, 32032, 39674, 47316, 54958 anti-HIV-1_LightChain 14659107, 16749, 24391, 32033, 39675, 47317, 54959 anti-HIV-1_LightChain1466 9108, 16750, 24392, 32034, 39676, 47318, 54960anti-HIV-1_LightChain 1467 9109, 16751, 24393, 32035, 39677, 47319,54961 anti-HIV-1_LightChain 1468 9110, 16752, 24394, 32036, 39678,47320, 54962 anti-HIV-1_LightChain 1469 9111, 16753, 24395, 32037,39679, 47321, 54963 anti-HIV-1_LightChain 1470 9112, 16754, 24396,32038, 39680, 47322, 54964 anti-HIV-1_LightChain 1471 9113, 16755,24397, 32039, 39681, 47323, 54965 anti-HIV-1_LightChain 1472 9114,16756, 24398, 32040, 39682, 47324, 54966 anti-HIV-1_LightChain 14739115, 16757, 24399, 32041, 39683, 47325, 54967 anti-HIV-1_LightChain1474 9116, 16758, 24400, 32042, 39684, 47326, 54968anti-HIV-1_LightChain 1475 9117, 16759, 24401, 32043, 39685, 47327,54969 anti-HIV-1_LightChain 1476 9118, 16760, 24402, 32044, 39686,47328, 54970 anti-HIV-1_LightChain 1477 9119, 16761, 24403, 32045,39687, 47329, 54971 anti-HIV-1_LightChain 1478 9120, 16762, 24404,32046, 39688, 47330, 54972 anti-HIV-1_LightChain 1479 9121, 16763,24405, 32047, 39689, 47331, 54973 anti-HIV-1_LightChain 1480 9122,16764, 24406, 32048, 39690, 47332, 54974 anti-HIV-1_LightChain 14819123, 16765, 24407, 32049, 39691, 47333, 54975 anti-HIV-1_LightChain1482 9124, 16766, 24408, 32050, 39692, 47334, 54976anti-HIV-1_LightChain 1483 9125, 16767, 24409, 32051, 39693, 47335,54977 anti-HIV-1_LightChain 1484 9126, 16768, 24410, 32052, 39694,47336, 54978 anti-HIV-1_LightChain 1485 9127, 16769, 24411, 32053,39695, 47337, 54979 anti-HIV-1_LightChain 1486 9128, 16770, 24412,32054, 39696, 47338, 54980 anti-HIV-1_LightChain 1487 9129, 16771,24413, 32055, 39697, 47339, 54981 anti-HIV-1_LightChain 1488 9130,16772, 24414, 32056, 39698, 47340, 54982 anti-HIV-1_LightChain 14899131, 16773, 24415, 32057, 39699, 47341, 54983 anti-HIV-1_LightChain1490 9132, 16774, 24416, 32058, 39700, 47342, 54984anti-HIV-1_LightChain 1491 9133, 16775, 24417, 32059, 39701, 47343,54985 anti-HIV-1_LightChain 1492 9134, 16776, 24418, 32060, 39702,47344, 54986 anti-HIV-1_LightChain 1493 9135, 16777, 24419, 32061,39703, 47345, 54987 anti-HIV-1_LightChain 1494 9136, 16778, 24420,32062, 39704, 47346, 54988 anti-HIV-1_LightChain 1495 9137, 16779,24421, 32063, 39705, 47347, 54989 anti-HIV-1_LightChain 1496 9138,16780, 24422, 32064, 39706, 47348, 54990 anti-HIV-1_LightChain 14979139, 16781, 24423, 32065, 39707, 47349, 54991 anti-HIV-1_LightChain1498 9140, 16782, 24424, 32066, 39708, 47350, 54992anti-HIV-1_LightChain 1499 9141, 16783, 24425, 32067, 39709, 47351,54993 anti-HIV-1_LightChain 1500 9142, 16784, 24426, 32068, 39710,47352, 54994 anti-HIV-1_LightChain 1501 9143, 16785, 24427, 32069,39711, 47353, 54995 anti-HIV-1_LightChain 1502 9144, 16786, 24428,32070, 39712, 47354, 54996 anti-HIV-1_LightChain 1503 9145, 16787,24429, 32071, 39713, 47355, 54997 anti-HIV-1_LightChain 1504 9146,16788, 24430, 32072, 39714, 47356, 54998 anti-HIV-1_LightChain 15059147, 16789, 24431, 32073, 39715, 47357, 54999 anti-HIV-1_LightChain1506 9148, 16790, 24432, 32074, 39716, 47358, 55000anti-HIV-1_LightChain 1507 9149, 16791, 24433, 32075, 39717, 47359,55001 anti-HIV-1_LightChain 1508 9150, 16792, 24434, 32076, 39718,47360, 55002 anti-HIV-1_LightChain 1509 9151, 16793, 24435, 32077,39719, 47361, 55003 anti-HIV-1_LightChain 1510 9152, 16794, 24436,32078, 39720, 47362, 55004 anti-HIV-1_LightChain 1511 9153, 16795,24437, 32079, 39721, 47363, 55005 anti-HIV-1_LightChain 1512 9154,16796, 24438, 32080, 39722, 47364, 55006 anti-HIV-1_LightChain 15139155, 16797, 24439, 32081, 39723, 47365, 55007 anti-HIV-1_LightChain1514 9156, 16798, 24440, 32082, 39724, 47366, 55008anti-HIV-1_LightChain 1515 9157, 16799, 24441, 32083, 39725, 47367,55009 anti-HIV-1_LightChain 1516 9158, 16800, 24442, 32084, 39726,47368, 55010 anti-HIV-1_LightChain 1517 9159, 16801, 24443, 32085,39727, 47369, 55011 anti-HIV-1_LightChain 1518 9160, 16802, 24444,32086, 39728, 47370, 55012 anti-HIV-1_LightChain 1519 9161, 16803,24445, 32087, 39729, 47371, 55013 anti-HIV-1_LightChain 1520 9162,16804, 24446, 32088, 39730, 47372, 55014 anti-HIV-1_LightChain 15219163, 16805, 24447, 32089, 39731, 47373, 55015 anti-HIV-1_LightChain1522 9164, 16806, 24448, 32090, 39732, 47374, 55016anti-HIV-1_LightChain 1523 9165, 16807, 24449, 32091, 39733, 47375,55017 anti-HIV-1_LightChain 1524 9166, 16808, 24450, 32092, 39734,47376, 55018 anti-HIV-1_LightChain 1525 9167, 16809, 24451, 32093,39735, 47377, 55019 anti-HIV-1_LightChain 1526 9168, 16810, 24452,32094, 39736, 47378, 55020 anti-HIV-1_LightChain 1527 9169, 16811,24453, 32095, 39737, 47379, 55021 anti-HIV-1_LightChain 1528 9170,16812, 24454, 32096, 39738, 47380, 55022 anti-HIV-1_LightChain 15299171, 16813, 24455, 32097, 39739, 47381, 55023 anti-HIV-1_LightChain1530 9172, 16814, 24456, 32098, 39740, 47382, 55024anti-HIV-1_LightChain 1531 9173, 16815, 24457, 32099, 39741, 47383,55025 anti-HIV-1_LightChain 1532 9174, 16816, 24458, 32100, 39742,47384, 55026 anti-HIV-1_LightChain 1533 9175, 16817, 24459, 32101,39743, 47385, 55027 anti-HIV-1_LightChain 1534 9176, 16818, 24460,32102, 39744, 47386, 55028 anti-HIV-1_LightChain 1535 9177, 16819,24461, 32103, 39745, 47387, 55029 anti-HIV-1_LightChain 1536 9178,16820, 24462, 32104, 39746, 47388, 55030 anti-HIV-1_LightChain 15379179, 16821, 24463, 32105, 39747, 47389, 55031 anti-HIV-1_LightChain1538 9180, 16822, 24464, 32106, 39748, 47390, 55032anti-HIV-1_LightChain 1539 9181, 16823, 24465, 32107, 39749, 47391,55033 anti-HIV-1_LightChain 1540 9182, 16824, 24466, 32108, 39750,47392, 55034 anti-HIV-1_LightChain 1541 9183, 16825, 24467, 32109,39751, 47393, 55035 anti-HIV-1_LightChain 1542 9184, 16826, 24468,32110, 39752, 47394, 55036 anti-HIV-1_LightChain 1543 9185, 16827,24469, 32111, 39753, 47395, 55037 anti-HIV-1_LightChain 1544 9186,16828, 24470, 32112, 39754, 47396, 55038 anti-HIV-1_LightChain 15459187, 16829, 24471, 32113, 39755, 47397, 55039 anti-HIV-1_LightChain1546 9188, 16830, 24472, 32114, 39756, 47398, 55040anti-HIV-1_LightChain 1547 9189, 16831, 24473, 32115, 39757, 47399,55041 anti-HIV-1_LightChain 1548 9190, 16832, 24474, 32116, 39758,47400, 55042 anti-HIV-1_LightChain 1549 9191, 16833, 24475, 32117,39759, 47401, 55043 anti-HIV-1_LightChain 1550 9192, 16834, 24476,32118, 39760, 47402, 55044 anti-HIV-1_LightChain 1551 9193, 16835,24477, 32119, 39761, 47403, 55045 anti-HIV-1_LightChain 1552 9194,16836, 24478, 32120, 39762, 47404, 55046 anti-HIV-1_LightChain 15539195, 16837, 24479, 32121, 39763, 47405, 55047 anti-HIV-1_LightChain1554 9196, 16838, 24480, 32122, 39764, 47406, 55048anti-HIV-1_LightChain 1555 9197, 16839, 24481, 32123, 39765, 47407,55049 anti-HIV-1_LightChain 1556 9198, 16840, 24482, 32124, 39766,47408, 55050 anti-HIV-1_LightChain 1557 9199, 16841, 24483, 32125,39767, 47409, 55051 anti-HIV-1_LightChain 1558 9200, 16842, 24484,32126, 39768, 47410, 55052 anti-HIV-1_LightChain 1559 9201, 16843,24485, 32127, 39769, 47411, 55053 anti-HIV-1_LightChain 1560 9202,16844, 24486, 32128, 39770, 47412, 55054 anti-HIV-1_LightChain 15619203, 16845, 24487, 32129, 39771, 47413, 55055 anti-HIV-1_LightChain1562 9204, 16846, 24488, 32130, 39772, 47414, 55056anti-HIV-1_LightChain 1563 9205, 16847, 24489, 32131, 39773, 47415,55057 anti-HIV-1_LightChain 1564 9206, 16848, 24490, 32132, 39774,47416, 55058 anti-HIV-1_LightChain 1565 9207, 16849, 24491, 32133,39775, 47417, 55059 anti-HIV-1_LightChain 1566 9208, 16850, 24492,32134, 39776, 47418, 55060 anti-HIV-1_LightChain 1567 9209, 16851,24493, 32135, 39777, 47419, 55061 anti-HIV-1_LightChain 1568 9210,16852, 24494, 32136, 39778, 47420, 55062 anti-HIV-1_LightChain 15699211, 16853, 24495, 32137, 39779, 47421, 55063 anti-HIV-1_LightChain1570 9212, 16854, 24496, 32138, 39780, 47422, 55064anti-HIV-1_LightChain 1571 9213, 16855, 24497, 32139, 39781, 47423,55065 anti-HIV-1_LightChain 1572 9214, 16856, 24498, 32140, 39782,47424, 55066 anti-HIV-1_LightChain 1573 9215, 16857, 24499, 32141,39783, 47425, 55067 anti-HIV-1_LightChain 1574 9216, 16858, 24500,32142, 39784, 47426, 55068 anti-HIV-1_LightChain 1575 9217, 16859,24501, 32143, 39785, 47427, 55069 anti-HIV-1_LightChain 1576 9218,16860, 24502, 32144, 39786, 47428, 55070 anti-HIV-1_LightChain 15779219, 16861, 24503, 32145, 39787, 47429, 55071 anti-HIV-1_LightChain1578 9220, 16862, 24504, 32146, 39788, 47430, 55072anti-HIV-1_LightChain 1579 9221, 16863, 24505, 32147, 39789, 47431,55073 anti-HIV-1_LightChain 1580 9222, 16864, 24506, 32148, 39790,47432, 55074 anti-HIV-1_LightChain 1581 9223, 16865, 24507, 32149,39791, 47433, 55075 anti-HIV-1_LightChain 1582 9224, 16866, 24508,32150, 39792, 47434, 55076 anti-HIV-1_LightChain 1583 9225, 16867,24509, 32151, 39793, 47435, 55077 anti-HIV-1_LightChain 1584 9226,16868, 24510, 32152, 39794, 47436, 55078 anti-HIV-1_LightChain 15859227, 16869, 24511, 32153, 39795, 47437, 55079 anti-HIV-1_LightChain1586 9228, 16870, 24512, 32154, 39796, 47438, 55080anti-HIV-1_LightChain 1587 9229, 16871, 24513, 32155, 39797, 47439,55081 anti-HIV-1_LightChain 1588 9230, 16872, 24514, 32156, 39798,47440, 55082 anti-HIV-1_LightChain 1589 9231, 16873, 24515, 32157,39799, 47441, 55083 anti-HIV-1_LightChain 1590 9232, 16874, 24516,32158, 39800, 47442, 55084 anti-HIV-1_LightChain 1591 9233, 16875,24517, 32159, 39801, 47443, 55085 anti-HIV-1_LightChain 1592 9234,16876, 24518, 32160, 39802, 47444, 55086 anti-HIV-1_LightChain 15939235, 16877, 24519, 32161, 39803, 47445, 55087 anti-HIV-1_LightChain1594 9236, 16878, 24520, 32162, 39804, 47446, 55088anti-HIV-1_LightChain 1595 9237, 16879, 24521, 32163, 39805, 47447,55089 anti-HIV-1_LightChain 1596 9238, 16880, 24522, 32164, 39806,47448, 55090 anti-HIV-1_LightChain 1597 9239, 16881, 24523, 32165,39807, 47449, 55091 anti-HIV-1_LightChain 1598 9240, 16882, 24524,32166, 39808, 47450, 55092 anti-HIV-1_LightChain 1599 9241, 16883,24525, 32167, 39809, 47451, 55093 anti-HIV-1_LightChain 1600 9242,16884, 24526, 32168, 39810, 47452, 55094 anti-HIV-1_LightChain 16019243, 16885, 24527, 32169, 39811, 47453, 55095 anti-HIV-1_LightChain1602 9244, 16886, 24528, 32170, 39812, 47454, 55096anti-HIV-1_LightChain 1603 9245, 16887, 24529, 32171, 39813, 47455,55097 anti-HIV-1_LightChain 1604 9246, 16888, 24530, 32172, 39814,47456, 55098 anti-HIV-1_LightChain 1605 9247, 16889, 24531, 32173,39815, 47457, 55099 anti-HIV-1_LightChain 1606 9248, 16890, 24532,32174, 39816, 47458, 55100 anti-HIV-1_LightChain 1607 9249, 16891,24533, 32175, 39817, 47459, 55101 anti-HIV-1_LightChain 1608 9250,16892, 24534, 32176, 39818, 47460, 55102 anti-HIV-1_HeavyChain 16099251, 16893, 24535, 32177, 39819, 47461, 55103 anti-HIV-1_HeavyChain1610 9252, 16894, 24536, 32178, 39820, 47462, 55104anti-HIV-1_HeavyChain 1611 9253, 16895, 24537, 32179, 39821, 47463,55105 anti-HIV-1_HeavyChain 1612 9254, 16896, 24538, 32180, 39822,47464, 55106 anti-HIV-1_HeavyChain 1613 9255, 16897, 24539, 32181,39823, 47465, 55107 anti-HIV-1_HeavyChain 1614 9256, 16898, 24540,32182, 39824, 47466, 55108 anti-HIV-1_HeavyChain 1615 9257, 16899,24541, 32183, 39825, 47467, 55109 anti-HIV-1_HeavyChain 1616 9258,16900, 24542, 32184, 39826, 47468, 55110 anti-HIV-1_HeavyChain 16179259, 16901, 24543, 32185, 39827, 47469, 55111 anti-HIV-1_HeavyChain1618 9260, 16902, 24544, 32186, 39828, 47470, 55112anti-HIV-1_HeavyChain 1619 9261, 16903, 24545, 32187, 39829, 47471,55113 anti-HIV-1_HeavyChain 1620 9262, 16904, 24546, 32188, 39830,47472, 55114 anti-HIV-1_HeavyChain 1621 9263, 16905, 24547, 32189,39831, 47473, 55115 anti-HIV-1_HeavyChain 1622 9264, 16906, 24548,32190, 39832, 47474, 55116 anti-HIV-1_HeavyChain 1623 9265, 16907,24549, 32191, 39833, 47475, 55117 anti-HIV-1_HeavyChain 1624 9266,16908, 24550, 32192, 39834, 47476, 55118 anti-HIV-1_HeavyChain 16259267, 16909, 24551, 32193, 39835, 47477, 55119 anti-HIV-1_HeavyChain1626 9268, 16910, 24552, 32194, 39836, 47478, 55120anti-HIV-1_HeavyChain 1627 9269, 16911, 24553, 32195, 39837, 47479,55121 anti-HIV-1_HeavyChain 1628 9270, 16912, 24554, 32196, 39838,47480, 55122 anti-HIV-1_HeavyChain 1629 9271, 16913, 24555, 32197,39839, 47481, 55123 anti-HIV-1_HeavyChain 1630 9272, 16914, 24556,32198, 39840, 47482, 55124 anti-HIV-1_HeavyChain 1631 9273, 16915,24557, 32199, 39841, 47483, 55125 anti-HIV-1_HeavyChain 1632 9274,16916, 24558, 32200, 39842, 47484, 55126 anti-HIV-1_HeavyChain 16339275, 16917, 24559, 32201, 39843, 47485, 55127 anti-HIV-1_HeavyChain1634 9276, 16918, 24560, 32202, 39844, 47486, 55128anti-HIV-1_HeavyChain 1635 9277, 16919, 24561, 32203, 39845, 47487,55129 anti-HIV-1_HeavyChain 1636 9278, 16920, 24562, 32204, 39846,47488, 55130 anti-HIV-1_HeavyChain 1637 9279, 16921, 24563, 32205,39847, 47489, 55131 anti-HIV-1_HeavyChain 1638 9280, 16922, 24564,32206, 39848, 47490, 55132 anti-HIV-1_HeavyChain 1639 9281, 16923,24565, 32207, 39849, 47491, 55133 anti-HIV-1_HeavyChain 1640 9282,16924, 24566, 32208, 39850, 47492, 55134 anti-HIV-1_HeavyChain 16419283, 16925, 24567, 32209, 39851, 47493, 55135 anti-HIV-1_HeavyChain1642 9284, 16926, 24568, 32210, 39852, 47494, 55136anti-HIV-1_HeavyChain 1643 9285, 16927, 24569, 32211, 39853, 47495,55137 anti-HIV-1_HeavyChain 1644 9286, 16928, 24570, 32212, 39854,47496, 55138 anti-HIV-1_HeavyChain 1645 9287, 16929, 24571, 32213,39855, 47497, 55139 anti-HIV-1_HeavyChain 1646 9288, 16930, 24572,32214, 39856, 47498, 55140 anti-HIV-1_HeavyChain 1647 9289, 16931,24573, 32215, 39857, 47499, 55141 anti-HIV-1_HeavyChain 1648 9290,16932, 24574, 32216, 39858, 47500, 55142 anti-HIV-1_HeavyChain 16499291, 16933, 24575, 32217, 39859, 47501, 55143 anti-HIV-1_HeavyChain1650 9292, 16934, 24576, 32218, 39860, 47502, 55144anti-HIV-1_HeavyChain 1651 9293, 16935, 24577, 32219, 39861, 47503,55145 anti-HIV-1_HeavyChain 1652 9294, 16936, 24578, 32220, 39862,47504, 55146 anti-HIV-1_HeavyChain 1653 9295, 16937, 24579, 32221,39863, 47505, 55147 anti-HIV-1_HeavyChain 1654 9296, 16938, 24580,32222, 39864, 47506, 55148 anti-HIV-1_HeavyChain 1655 9297, 16939,24581, 32223, 39865, 47507, 55149 anti-HIV_C38-VRC18.02_HeavyChain 16569298, 16940, 24582, 32224, 39856, 47508, 55150anti-HIV_44-VRC13.02_HeavyChain 1657 9299, 16941, 24583, 32225, 39867,47509, 55151 anti-HIV-1_LightChain 1658 9300, 16942, 24584, 32226,39868, 47510, 55152 anti-HIV-1_LightChain 1659 9301, 16943, 24585,32227, 39869, 47511, 55153 anti-HIV-1_LightChain 1660 9302, 16944,24586, 32228, 39870, 47512, 55154 anti-HIV-1_LightChain 1661 9303,16945, 24587, 32229, 39871, 47513, 55155 anti-HIV-1_LightChain 16629304, 16946, 24588, 32230, 39872, 47514, 55156 anti-HIV-1_LightChain1663 9305, 16947, 24589, 32231, 39873, 47515, 55157anti-HIV-1_LightChain 1664 9306, 16948, 24590, 32232, 39874, 47516,55158 anti-HIV-1_HeavyChain 1665 9307, 16949, 24591, 32233, 39875,47517, 55159 anti-HIV-1_HeavyChain 1666 9308, 16950, 24592, 32234,39876, 47518, 55160 anti-HIV-1_HeavyChain 1667 9309, 16951, 24593,32235, 39877, 47519, 55161 anti-HIV-1_HeavyChain 1668 9310, 16952,24594, 32236, 39878, 47520, 55162 anti-HIV-1_HeavyChain 1669 9311,16953, 24595, 32237, 39879, 47521, 55163 anti-HIV-1_HeavyChain 16709312, 16954, 24596, 32238, 39880, 47522, 55164 anti-HIV-1_HeavyChain1671 9313, 16955, 24597, 32239, 39881, 47523, 55165anti-HIV_45_LightChain 1672 9314, 16956, 24598, 32240, 39882, 47524,55165 anti-HIV_45_LightChain 1673 9315, 16957, 24599, 32241, 39883,47525, 55167 anti-HIV_45_LightChain 1674 9316, 16958, 24600, 32242,39884, 47526, 55168 anti-HIV_45_HeavyChain 1675 9317, 16959, 24601,32243, 39885, 47527, 55169 anti-HIV_45_HeavyChain 1676 9318, 16960,24602, 32244, 39886, 47528, 55170 anti-HIV_45_HeavyChain 1677 9319,16961, 24603, 32245, 39887, 47529, 55171anti-HIV_cap256-206-252885_VR-Chain 1678 9320, 16962, 24604, 32246,39888, 47530, 55172 anti-HIV_cap256-206-249183_VR-Chain 1679 9321,16963, 24605, 32247, 39889, 47531, 55173anti-HIV_cap256-206-220956_VR-Chain 1680 9322, 16964, 24606, 32248,39890, 47532, 55174 anti-HIV_cap256-206-220629_VR-Chain 1681 9323,16965, 24607, 32249, 39891, 47533, 55175anti-HIV_cap256-206-200599_VR-Chain 1682 9324, 16966, 24608, 32250,39892, 47534, 55176 anti-HIV_cap256-206-186347_VR-Chain 1683 9325,16967, 24609, 32251, 39893, 47535, 55177anti-HIV_cap256-206-186226_VR-Chain 1684 9326, 16968, 24610, 32252,39894, 47536, 55178 anti-HIV_cap256-206-179686_VR-Chain 1685 9327,16969, 24611, 32253, 39895, 47537, 55179anti-HIV_cap256-206-173707_VR-Chain 1686 9328, 16970, 24612, 32254,39896, 47538, 55180 anti-HIV_cap256-206-173339_VR-Chain 1687 9329,16971, 24613, 32255, 39897, 47539, 55181anti-HIV_cap256-206-172689_VR-Chain 1688 9330, 16972, 24614, 32256,39898, 47540, 55182 anti-HIV_cap256-206-162744_VR-Chain 1689 9331,16973, 24615, 32257, 39899, 47541, 55183anti-HIV_cap256-206-146057_VR-Chain 1690 9332, 16974, 24616, 32258,39900, 47542, 55184 anti-HIV_cap256-206-139519_VR-Chain 1691 9333,16975, 24617, 32259, 39901, 47543, 55185anti-HIV_cap256-206-136316_VR-Chain 1692 9334, 16976, 24618, 32260,39902, 47544, 55186 anti-HIV_cap256-206-116098_VR-Chain 1693 9335,16977, 24619, 32261, 39903, 47545, 55187anti-HIV_cap256-206-115862_VR-Chain 1694 9336, 16978, 24620, 32262,39904, 47546, 55188 anti-HIV_cap256-206-107018_VR-Chain 1695 9337,16979, 24621, 32263, 39905, 47547, 55189anti-HIV_cap256-206-098644_VR-Chain 1696 9338, 16980, 24622, 32264,39906, 47548, 55190 anti-HIV_cap256-206-098135_VR-Chain 1697 9339,16981, 24623, 32265, 39907, 47549, 55191anti-HIV_cap256-206-096276_VR-Chain 1698 9340, 16982, 24624, 32266,39908, 47550, 55192 anti-HIV_cap256-206-092794_VR-Chain 1699 9341,16983, 24625, 32267, 39909, 47551, 55193anti-HIV_cap256-206-086817_VR-Chain 1700 9342, 16984, 24626, 32268,39910, 47552, 55194 anti-HIV_cap256-206-086446_VR-Chain 1701 9343,16985, 24627, 32269, 39911, 47553, 55195anti-HIV_cap256-206-086180_VR-Chain 1702 9344, 16986, 24628, 32270,39912, 47554, 55196 anti-HIV_cap256-206-083708_VR-Chain 1703 9345,16987, 24629, 32271, 39913, 47555, 55197anti-HIV_cap256-206-079556_VR-Chain 1704 9346, 16988, 24630, 32272,39914, 47556, 55198 anti-HIV_cap256-206-078657_VR-Chain 1705 9347,16989, 24631, 32273, 39915, 47557, 55199anti-HIV_cap256-206-075802_VR-Chain 1706 9348, 16990, 24632, 32274,39916, 47558, 55200 anti-HIV_cap256-206-069097_VR-Chain 1707 9349,16991, 24633, 32275, 39917, 47559, 55201anti-HIV_cap256-206-067758_VR-Chain 1708 9350, 16992, 24634, 32276,39918, 47560, 55202 anti-HIV_cap256-206-057019_VR-Chain 1709 9351,16993, 24635, 32277, 39919, 47561, 55203anti-HIV_cap256-206-055385_VR-Chain 1710 9352, 16994, 24636, 32278,39920, 47562, 55204 anti-HIV_cap256-206-053187_VR-Chain 1711 9353,16995, 24637, 32279, 39921, 47563, 55205anti-HIV_cap256-206-053139_VR-Chain 1712 9354, 16996, 24638, 32280,39922, 47564, 55206 anti-HIV_cap256-206-050350_VR-Chain 1713 9355,16997, 24639, 32281, 39923, 47565, 55207anti-HIV_cap256-206-046207_VR-Chain 1714 9356, 16998, 24640, 32282,39924, 47566, 55208 anti-HIV_cap256-206-043389_VR-Chain 1715 9357,16999, 24641, 32283, 39925, 47567, 55209anti-HIV_cap256-206-042555_VR-Chain 1716 9358, 17000, 24642, 32284,39926, 47568, 55210 anti-HIV_cap256-206-029720_VR-Chain 1717 9359,17001, 24643, 32285, 39927, 47596, 55211anti-HIV_cap256-206-028848_VR-Chain 1718 9360, 17002, 24644, 32286,39928, 47570, 55212 anti-HIV_cap256-206-027652_VR-Chain 1719 9361,17003, 24645, 32287, 39929, 47571, 55213anti-HIV_cap256-206-024075_VR-Chain 1720 9362, 17004, 24646, 32288,39930, 47572, 55214 anti-HIV_cap256-206-008748_VR-Chain 1721 9363,17005, 24647, 32289, 39931, 47573, 55215anti-HIV_cap256-206-008530_VR-Chain 1722 9364, 17009, 24648, 32290,39932, 47574, 55216 anti-HIV_cap256-176-723043_VR-Chain 1723 9365,17007, 24649, 32291, 39933, 47575, 55217anti-HIV_cap256-176-600049_VR-Chain 1724 9366, 17008, 24650, 32292,39934, 47576, 55218 anti-HIV_cap256-176-531926_VR-Chain 1725 9367,17009, 24651, 32293, 39935, 47577, 55219anti-HIV_cap256-176-504134_VR-Chain 1726 9368, 17010, 24652, 32294,39936, 47578, 55220 anti-HIV_cap256-119-186229_VR-Chain 1727 9369,17011, 24653, 32295, 39937, 47579, 55221anti-HIV_cap256-119-183891_VR-Chain 1728 9370, 17012, 24654, 32296,39938, 47580, 55222 anti-HIV_cap256-119-183631_VR-Chain 1729 9371,17013, 24655, 32297, 39939, 47581, 55223anti-HIV_cap256-119-182676_VR-Chain 1730 9372, 17014, 24656, 32298,39940, 47582, 55224 anti-HIV_cap256-119-180772_VR-Chain 1731 9373,17015, 24657, 32299, 39941, 47583, 55225anti-HIV_cap256-119-180508_VR-Chain 1732 9374, 17016, 24658, 32300,39942, 47584, 55226 anti-HIV_cap256-119-180260_VR-Chain 1733 9375,17017, 24659, 32301, 39943, 47585, 55227anti-HIV_cap256-119-180173_VR-Chain 1734 9376, 17018, 24660, 32302,39944, 47586, 55228 anti-HIV_cap256-119-179839_VR-Chain 1735 9377,17019, 24661, 32303, 39945, 47587, 55229anti-HIV_cap256-119-179262_VR-Chain 1736 9378, 17020, 24662, 32304,39946, 47588, 55230 anti-HIV_cap256-119-178995_VR-Chain 1737 9379,17021, 24663, 32305, 39947, 47589, 55231anti-HIV_cap256-119-178455_VR-Chain 1738 9380, 17022, 24664, 32306,39948, 47590, 55232 anti-HIV_cap256-119-177993_VR-Chain 1739 9381,17023, 24665, 32307, 39949, 47591, 55233anti-HIV_cap256-119-177727_VR-Chain 1740 9382, 17024, 24666, 32308,39950, 47592, 55234 anti-HIV_cap256-119-176746_VR-Chain 1741 9383,17025, 24667, 32309, 39951, 47593, 55235anti-HIV_cap256-119-176241_VR-Chain 1742 9384, 17026, 24668, 32310,39952, 47594, 55236 anti-HIV_cap256-119-175215_VR-Chain 1743 9385,17027, 24669, 32311, 39953, 47595, 55237anti-HIV_cap256-119-173928_VR-Chain 1744 9386, 17028, 24670, 32312,39954, 47596, 55238 anti-HIV_cap256-119-173495_VR-Chain 1745 9387,17029, 24671, 32313, 39955, 47597, 55239anti-HIV_cap256-119-172882_VR-Chain 1746 9388, 17030, 24672, 32314,39956, 47598, 55240 anti-HIV_cap256-119-172429_VR-Chain 1747 9389,17031, 24673, 32315, 39957, 47599, 55241anti-HIV_cap256-119-172223_VR-Chain 1748 9390, 17032, 24674, 32316,39958, 47600, 55242 anti-HIV_cap256-119-171838_VR-Chain 1749 9391,17033, 24675, 32317, 39959, 47601, 55243anti-HIV_cap256-119-171587_VR-Chain 1750 9392, 17034, 24676, 32318,39960, 47602, 55244 anti-HIV_cap256-119-169596_VR-Chain 1751 9393,17035, 24677, 32319, 39961, 47603, 55245anti-HIV_cap256-119-169523_VR-Chain 1752 9394, 17036, 24678, 32320,39962, 47604, 55246 anti-HIV_cap256-119-169462_VR-Chain 1753 9395,17037, 24679, 32321, 39963, 47605, 55247anti-HIV_cap256-119-169092_VR-Chain 1754 9396, 17038, 24680, 32322,39964, 47606, 55248 anti-HIV_cap256-119-168680_VR-Chain 1755 9397,17039, 24681, 32323, 39965, 47607, 55249anti-HIV_cap256-119-166385_VR-Chain 1756 9398, 17040, 24682, 32324,39966, 47608, 55250 anti-HIV_cap256-119-165943_VR-Chain 1757 9399,17041, 24683, 32325, 39967, 47609, 55251anti-HIV_cap256-119-165738_VR-Chain 1758 9400, 17042, 24684, 32326,39968, 47610, 55252 anti-HIV_cap256-119-164913_VR-Chain 1759 9401,17043, 24685, 32327, 39969, 47611, 55253anti-HIV_cap256-119-164167_VR-Chain 1760 9402, 17044, 24686, 32328,39970, 47612, 55254 anti-HIV_cap256-119-163558_VR-Chain 1761 9403,17045, 24687, 32329, 39971, 47613, 55255anti-HIV_cap256-119-162043_VR-Chain 1762 9404, 17046, 24688, 32330,39972, 47614, 55256 anti-HIV_cap256-119-161718_VR-Chain 1763 9405,17047, 24689, 32331, 39973, 47615, 55257anti-HIV_cap256-119-161675_VR-Chain 1764 9406, 17048, 24690, 32332,39974, 47616, 55258 anti-HIV_cap256-119-161053_VR-Chain 1765 9407,17049, 24691, 32333, 39975, 47617, 55259anti-HIV_cap256-119-159499_VR-Chain 1766 9408, 17050, 24692, 32334,39976, 47618, 55260 anti-HIV_cap256-119-159114_VR-Chain 1767 9409,17051, 24693, 32335, 39977, 47619, 55261anti-HIV_cap256-119-156751_VR-Chain 1768 9410, 17052, 24694, 32336,39978, 47620, 55262 anti-HIV_cap256-119-155656_VR-Chain 1769 9411,17053, 24695, 32337, 39979, 47621, 55263anti-HIV_cap256-119-154420_VR-Chain 1770 9412, 17054, 24696, 32338,39980, 47622, 55264 anti-HIV_cap256-119-153954_VR-Chain 1771 9413,17055, 24697, 32339, 39981, 47623, 55265anti-HIV_cap256-119-153864_VR-Chain 1772 9414, 17056, 24698, 32340,39982, 47624, 55266 anti-HIV_cap256-119-153793_VR-Chain 1773 9415,17057, 24699, 32341, 39983, 47625, 55267anti-HIV_cap256-119-153462_VR-Chain 1774 9416, 17058, 24700, 32342,39984, 47626, 55268 anti-HIV_cap256-119-153124_VR-Chain 1775 9417,17059, 24701, 32343, 39985, 47627, 55269anti-HIV_cap256-119-153025_VR-Chain 1776 9418, 17060, 24702, 32344,39986, 47628, 55270 anti-HIV_cap256-119-152713_VR-Chain 1777 9419,17061, 24703, 32345, 39987, 47629, 55271anti-HIV_cap256-119-151794_VR-Chain 1778 9420, 17062, 24704, 32346,39988, 47630, 55272 anti-HIV_cap256-119-150980_VR-Chain 1779 9421,17063, 24705, 32347, 39989, 47631, 55273anti-HIV_cap256-119-148895_VR-Chain 1780 9422, 17064, 24706, 32348,39990, 47632, 55274 anti-HIV_cap256-119-148848_VR-Chain 1781 9423,17065, 24707, 32349, 39991, 47633, 55275anti-HIV_cap256-119-148743_VR-Chain 1782 9424, 17066, 24708, 32350,39992, 47634, 55276 anti-HIV_cap256-119-148595_VR-Chain 1783 9425,17067, 24709, 32351, 39993, 47635, 55277anti-HIV_cap256-119-148490_VR-Chain 1784 9426, 17068, 24710, 32352,39994, 47636, 55278 anti-HIV_cap256-119-148470_VR-Chain 1785 9427,17069, 24711, 32353, 39995, 47637, 55279anti-HIV_cap256-119-148107_VR-Chain 1786 9428, 17070, 24712, 32354,39996, 47638, 55280 anti-HIV_cap256-119-147933_VR-Chain 1787 9429,17071, 24713, 32355, 39997, 47639, 55281anti-HIV_cap256-119-147434_VR-Chain 1788 9430, 17072, 24714, 32356,39998, 47640, 55282 anti-HIV_cap256-119-146106_VR-Chain 1789 9431,17073, 24715, 32357, 39999, 47641, 55283anti-HIV_cap256-119-145604_VR-Chain 1790 9432, 17074, 24716, 32358,40000, 47642, 55284 anti-HIV_cap256-119-143998_VR-Chain 1791 9433,17075, 24717, 32359, 40001, 47643, 55285anti-HIV_cap256-119-143441_VR-Chain 1792 9434, 17076, 24718, 32360,40002, 47644, 55286 anti-HIV_cap256-119-141307_VR-Chain 1793 9435,17077, 24719, 32361, 40003, 47645, 55287anti-HIV_cap256-119-140896_VR-Chain 1794 9436, 17078, 24720, 32362,40004, 47646, 55288 anti-HIV_cap256-119-140090_VR-Chain 1795 9437,17079, 24721, 32363, 40005, 47647, 55289anti-HIV_cap256-119-140037_VR-Chain 1796 9438, 17080, 24722, 32364,40006, 47648, 55290 anti-HIV_cap256-119-139135_VR-Chain 1797 9439,17081, 24723, 32365, 40007, 47649, 55291anti-HIV_cap256-119-137881_VR-Chain 1798 9440, 17082, 24724, 32366,40008, 47650, 55292 anti-HIV_cap256-119-137643_VR-Chain 1799 9441,17083, 24725, 32367, 40009, 47651, 55293anti-HIV_cap256-119-137170_VR-Chain 1800 9442, 17084, 24726, 32368,40010, 47652, 55294 anti-HIV_cap256-119-136616_VR-Chain 1801 9443,17085, 24727, 32369, 40011, 47653, 55295anti-HIV_cap256-119-136206_VR-Chain 1802 9444, 17086, 24728, 32370,40012, 47654, 55296 anti-HIV_cap256-119-135565_VR-Chain 1803 9445,17087, 24729, 32371, 40013, 47655, 55297anti-HIV_cap256-119-135025_VR-Chain 1804 9446, 17088, 24730, 32372,40014, 47656, 55298 anti-HIV_cap256-119-133983_VR-Chain 1805 9447,17089, 24731, 32373, 40015, 47657, 55299anti-HIV_cap256-119-133917_VR-Chain 1806 9448, 17090, 24732, 32374,40016, 47658, 55300 anti-HIV_cap256-119-132663_VR-Chain 1807 9449,17091, 24733, 32375, 40017, 47659, 55301anti-HIV_cap256-119-132113_VR-Chain 1808 9450, 17092, 24734, 32376,40018, 47660, 55302 anti-HIV_cap256-119-131839_VR-Chain 1809 9451,17093, 24735, 32377, 40019, 47661, 55303anti-HIV_cap256-119-130626_VR-Chain 1810 9452, 17094, 24736, 32378,40020, 47662, 55304 anti-HIV_cap256-119-130191_VR-Chain 1811 9453,17095, 24737, 32379, 40021, 47663, 55305anti-HIV_cap256-119-129798_VR-Chain 1812 9454, 17096, 24738, 32380,40022, 47664, 55306 anti-HIV_cap256-119-128745_VR-Chain 1813 9455,17097, 24739, 32381, 40023, 47665, 55307anti-HIV_cap256-119-128593_VR-Chain 1814 9456, 17098, 24740, 32382,40024, 47666, 55308 anti-HIV_cap256-119-128152_VR-Chain 1815 9457,17099, 24741, 32383, 40025, 47667, 55309anti-HIV_cap256-119-127693_VR-Chain 1816 9458, 17100, 24742, 32384,40026, 47668, 55310 anti-HIV_cap256-119-126684_VR-Chain 1817 9459,17101, 24743, 32385, 40027, 47669, 55311anti-HIV_cap256-119-126056_VR-Chain 1818 9460, 17102, 24744, 32386,40028, 47670, 55312 anti-HIV_cap256-119-125765_VR-Chain 1819 9461,17103, 24745, 32387, 40029, 47671, 55313anti-HIV_cap256-119-125106_VR-Chain 1820 9462, 17104, 24746, 32388,40030, 47672, 55314 anti-HIV_cap256-119-124026_VR-Chain 1821 9463,17105, 24747, 32389, 40031, 47673, 55315anti-HIV_cap256-119-121783_VR-Chain 1822 9464, 17106, 24748, 32390,40032, 47674, 55316 anti-HIV_cap256-119-121208_VR-Chain 1823 9465,17107, 24749, 32391, 40033, 47675, 55317anti-HIV_cap256-119-120945_VR-Chain 1824 9466, 17108, 24750, 32392,40034, 47676, 55318 anti-HIV_cap256-119-118229_VR-Chain 1825 9467,17109, 24751, 32393, 40035, 47677, 55319anti-HIV_cap256-119-118025_VR-Chain 1826 9468, 17110, 24752, 32394,40036, 47678, 55320 anti-HIV_cap256-119-117418_VR-Chain 1827 9469,17111, 24753, 32395, 40037, 47679, 55321anti-HIV_cap256-119-117250_VR-Chain 1828 9470, 17112, 24754, 32396,40038, 47680, 55322 anti-HIV_cap256-119-117230_VR-Chain 1829 9471,17113, 24755, 32397, 40039, 47681, 55323anti-HIV_cap256-119-116999_VR-Chain 1830 9472, 17114, 24756, 32398,40040, 47682, 55324 anti-HIV_cap256-119-116558_VR-Chain 1831 9473,17115, 24757, 32399, 40041, 47683, 55325anti-HIV_cap256-119-116484_VR-Chain 1832 9474, 17116, 24758, 32400,40042, 47684, 55326 anti-HIV_cap256-119-114844_VR-Chain 1833 9475,17117, 24759, 32401, 40043, 47685, 55327anti-HIV_cap256-119-114141_VR-Chain 1834 9476, 17118, 24760, 32402,40044, 47686, 55328 anti-HIV_cap256-119-111917_VR-Chain 1835 9477,17119, 24761, 32403, 40045, 47687, 55329anti-HIV_cap256-119-111862_VR-Chain 1836 9478, 17120, 24762, 32404,40046, 47688, 55330 anti-HIV_cap256-119-110064_VR-Chain 1837 9479,17121, 24763, 32405, 40047, 47689, 55331anti-HIV_cap256-119-109192_VR-Chain 1838 9480, 17122, 24764, 32406,40048, 47690, 55332 anti-HIV_cap256-119-108793_VR-Chain 1839 9481,17123, 24765, 32407, 40049, 47691, 55333anti-HIV_cap256-119-108127_VR-Chain 1840 9482, 17124, 24766, 32408,40050, 47692, 55334 anti-HIV_cap256-119-107758_VR-Chain 1841 9483,17125, 24767, 32409, 40051, 47693, 55335anti-HIV_cap256-119-107209_VR-Chain 1842 9484, 17126, 24768, 32410,40052, 47694, 55336 anti-HIV_cap256-119-107184_VR-Chain 1843 9485,17127, 24769, 32411, 40053, 47695, 55337anti-HIV_cap256-119-106827_VR-Chain 1844 9486, 17128, 24770, 32412,40054, 47696, 55338 anti-HIV_cap256-119-106511_VR-Chain 1845 9487,17129, 24771, 32413, 40055, 47697, 55339anti-HIV_cap256-119-106327_VR-Chain 1846 9488, 17130, 24772, 32414,40056, 47698, 55340 anti-HIV_cap256-119-105486_VR-Chain 1847 9489,17131, 24773, 32415, 40057, 47699, 55341anti-HIV_cap256-119-105197_VR-Chain 1848 9490, 17132, 24774, 32416,40058, 47700, 55342 anti-HIV_cap256-119-104946_VR-Chain 1849 9491,17133, 24775, 32417, 40059, 47701, 55343anti-HIV_cap256-119-103667_VR-Chain 1850 9492, 17134, 24776, 32418,40060, 47702, 55344 anti-HIV_cap256-119-103385_VR-Chain 1851 9493,17135, 24777, 32419, 40061, 47703, 55345anti-HIV_cap256-119-103267_VR-Chain 1852 9494, 17136, 24778, 32420,40062, 47704, 55346 anti-HIV_cap256-119-103011_VR-Chain 1853 9495,17137, 24779, 32421, 40063, 47705, 55347anti-HIV_cap256-119-102072_VR-Chain 1854 9496, 17138, 24780, 32422,40064, 47706, 55348 anti-HIV_cap256-119-101945_VR-Chain 1855 9497,17139, 24781, 32423, 40065, 47707, 55349anti-HIV_cap256-119-101319_VR-Chain 1856 9498, 17140, 24782, 32424,40066, 47708, 55350 anti-HIV_cap256-119-100871_VR-Chain 1857 9499,17141, 24783, 32425, 40067, 47709, 55351anti-HIV_cap256-119-100838_VR-Chain 1858 9500, 17142, 24784, 32426,40068, 47710, 55352 anti-HIV_cap256-119-100025_VR-Chain 1859 9501,17143, 24785, 32427, 40069, 47711, 55353anti-HIV_cap256-119-100000_VR-Chain 1860 9502, 17144, 24786, 32428,40070, 47712, 55354 anti-HIV_cap256-119-098890_VR-Chain 1861 9503,17145, 24787, 32429, 40071, 47713, 55355anti-HIV_cap256-119-098715_VR-Chain 1862 9504, 17146, 24788, 32430,40072, 47714, 55356 anti-HIV_cap256-119-098632_VR-Chain 1863 9505,17147, 24789, 32431, 40073, 47715, 55357anti-HIV_cap256-119-097199_VR-Chain 1864 9506, 17148, 24790, 32432,40074, 47716, 55358 anti-HIV_cap256-119-096189_VR-Chain 1865 9507,17149, 24791, 32433, 40075, 47717, 55359anti-HIV_cap256-119-094581_VR-Chain 1866 9508, 17150, 24792, 32434,40076, 47718, 55360 anti-HIV_cap256-119-094200_VR-Chain 1867 9509,17151, 24793, 32435, 40077, 47719, 55361anti-HIV_cap256-119-094158_VR-Chain 1868 9510, 17152, 24794, 32436,40078, 47720, 55362 anti-HIV_cap256-119-092814_VR-Chain 1869 9511,17153, 24795, 32437, 40079, 47721, 55363anti-HIV_cap256-119-092808_VR-Chain 1870 9512, 17154, 24796, 32438,40080, 47722, 55364 anti-HIV_cap256-119-092573_VR-Chain 1871 9513,17155, 24797, 32439, 40081, 47723, 55365anti-HIV_cap256-119-090815_VR-Chain 1872 9514, 17156, 24798, 32440,40082, 47724, 55366 anti-HIV_cap256-119-090368_VR-Chain 1873 9515,17157, 24799, 32441, 40083, 47725, 55367anti-HIV_cap256-119-089710_VR-Chain 1874 9516, 17158, 24800, 32442,40084, 47726, 55368 anti-HIV_cap256-119-088555_VR-Chain 1875 9517,17159, 24801, 32443, 40085, 47727, 55369anti-HIV_cap256-119-087962_VR-Chain 1876 9518, 17160, 24802, 32444,40086, 47728, 55370 anti-HIV_cap256-119-086903_VR-Chain 1877 9519,17161, 24803, 32445, 40087, 47729, 55371anti-HIV_cap256-119-086804_VR-Chain 1878 9520, 17162, 24804, 32446,40088, 47730, 55372 anti-HIV_cap256-119-085910_VR-Chain 1879 9521,17163, 24805, 32447, 40089, 47731, 55373anti-HIV_cap256-119-085772_VR-Chain 1880 9522, 17164, 24806, 32448,40090, 47732, 55374 anti-HIV_cap256-119-084603_VR-Chain 1881 9523,17165, 24807, 32449, 40091, 47733, 55375anti-HIV_cap256-119-084276_VR-Chain 1882 9524, 17166, 24808, 32450,40092, 47734, 55376 anti-HIV_cap256-119-082288_VR-Chain 1883 9525,17167, 24809, 32451, 40093, 47735, 55377anti-HIV_cap256-119-080383_VR-Chain 1884 9526, 17168, 24810, 32452,40094, 47736, 55378 anti-HIV_cap256-119-079333_VR-Chain 1885 9527,17169, 24811, 32453, 40095, 47737, 55379anti-HIV_cap256-119-078618_VR-Chain 1886 9528, 17170, 24812, 32454,40096, 47738, 55380 anti-HIV_cap256-119-077466_VR-Chain 1887 9529,17171, 24813, 32455, 40097, 47739, 55381anti-HIV_cap256-119-076284_VR-Chain 1888 9530, 17172, 24814, 32456,40098, 47740, 55382 anti-HIV_cap256-119-074680_VR-Chain 1889 9531,17173, 24815, 32457, 40099, 47741, 55383anti-HIV_cap256-119-074081_VR-Chain 1890 9532, 17174, 24816, 32458,40100, 47742, 55384 anti-HIV_cap256-119-071704_VR-Chain 1891 9533,17175, 24817, 32459, 40101, 47743, 55385anti-HIV_cap256-119-071266_VR-Chain 1892 9534, 17176, 24818, 32460,40102, 47744, 55386 anti-HIV_cap256-119-069667_VR-Chain 1893 9535,17177, 24819, 32461, 40103, 47745, 55387anti-HIV_cap256-119-069591_VR-Chain 1894 9536, 17178, 24820, 32462,40104, 47746, 55388 anti-HIV_cap256-119-068691_VR-Chain 1895 9537,17179, 24821, 32463, 40105, 47747, 55389anti-HIV_cap256-119-068488_VR-Chain 1896 9538, 17180, 24822, 32464,40106, 47748, 55390 anti-HIV_cap256-119-067536_VR-Chain 1897 9539,17181, 24823, 32465, 40107, 47749, 55391anti-HIV_cap256-119-065852_VR-Chain 1898 9540, 17182, 24824, 32466,40108, 47750, 55392 anti-HIV_cap256-119-065457_VR-Chain 1899 9541,17183, 24825, 32467, 40109, 47751, 55393anti-HIV_cap256-119-064501_VR-Chain 1900 9542, 17184, 24826, 32468,40110, 47752, 55394 anti-HIV_cap256-119-063568_VR-Chain 1901 9543,17185, 24827, 32469, 40111, 47753, 55395anti-HIV_cap256-119-063103_VR-Chain 1902 9544, 17186, 24828, 32470,40112, 47754, 55396 anti-HIV_cap256-119-061027_VR-Chain 1903 9545,17187, 24829, 32471, 40113, 47755, 55397anti-HIV_cap256-119-058232_VR-Chain 1904 9546, 17188, 24830, 32472,40114, 47756, 55398 anti-HIV_cap256-119-057341_VR-Chain 1905 9547,17189, 24831, 32473, 40115, 47757, 55399anti-HIV_cap256-119-056895_VR-Chain 1906 9548, 17190, 24832, 32474,40116, 47758, 55400 anti-HIV_cap256-119-056402_VR-Chain 1907 9549,17191, 24833, 32475, 40117, 47759, 55401anti-HIV_cap256-119-056034_VR-Chain 1908 9550, 17192, 24834, 32476,40118, 47760, 55402 anti-HIV_cap256-119-055042_VR-Chain 1909 9551,17193, 24835, 32477, 40119, 47761, 55403anti-HIV_cap256-119-054776_VR-Chain 1910 9552, 17194, 24836, 32478,40120, 47762, 55404 anti-HIV_cap256-119-054539_VR-Chain 1911 9553,17195, 24837, 32479, 40121, 47763, 55405anti-HIV_cap256-119-054112_VR-Chain 1912 9554, 17199, 24838, 32480,40122, 47764, 55406 anti-HIV_cap256-119-053339_VR-Chain 1913 9555,17197, 24839, 32481, 40123, 47765, 55407anti-HIV_cap256-119-052404_VR-Chain 1914 9556, 17198, 24840, 32482,40124, 47766, 55408 anti-HIV_cap256-119-051123_VR-Chain 1915 9557,17199, 24841, 32483, 40125, 47767, 55409anti-HIV_cap256-119-051077_VR-Chain 1916 9558, 17200, 24842, 32484,40126, 47768, 55410 anti-HIV_cap256-119-050442_VR-Chain 1917 9559,17201, 24843, 32485, 40127, 47769, 55411anti-HIV_cap256-119-049433_VR-Chain 1918 9560, 17202, 24844, 32486,40128, 47770, 55412 anti-HIV_cap256-119-047532_VR-Chain 1919 9561,17203, 24845, 32487, 40129, 47771, 55413anti-HIV_cap256-119-047489_VR-Chain 1920 9562, 17204, 24846, 32488,40130, 47772, 55414 anti-HIV_cap256-119-046020_VR-Chain 1921 9563,17205, 24847, 32489, 40131, 47773, 55415anti-HIV_cap256-119-044746_VR-Chain 1922 9564, 17206, 24848, 32490,40132, 47774, 55416 anti-HIV_cap256-119-044740_VR-Chain 1923 9565,17207, 24849, 32491, 40133, 47775, 55417anti-HIV_cap256-119-043790_VR-Chain 1924 9566, 17208, 24850, 32492,40134, 47776, 55418 anti-HIV_cap256-119-042880_VR-Chain 1925 9567,17209, 24851, 32493, 40135, 47777, 55419anti-HIV_cap256-119-042606_VR-Chain 1926 9568, 17210, 24852, 32494,40136, 47778, 55420 anti-HIV_cap256-119-042444_VR-Chain 1927 9569,17211, 24853, 32495, 40137, 47779, 55421anti-HIV_cap256-119-040328_VR-Chain 1928 9570, 17212, 24854, 32496,40138, 47780, 55422 anti-HIV_cap256-119-040164_VR-Chain 1929 9571,17213, 24855, 32497, 40139, 47781, 55423anti-HIV_cap256-119-039130_VR-Chain 1930 9572, 17214, 24856, 32498,40140, 47782, 55424 anti-HIV_cap256-119-038138_VR-Chain 1931 9573,17215, 24857, 32499, 40141, 47783, 55425anti-HIV_cap256-119-037868_VR-Chain 1932 9574, 17216, 24858, 32500,40142, 47784, 55426 anti-HIV_cap256-119-037102_VR-Chain 1933 9575,17217, 24859, 32501, 40143, 47785, 55427anti-HIV_cap256-119-036683_VR-Chain 1934 9576, 17218, 24860, 32502,40144, 47786, 55428 anti-HIV_cap256-119-036495_VR-Chain 1935 9577,17219, 24861, 32503, 40145, 47787, 55429anti-HIV_cap256-119-035375_VR-Chain 1936 9578, 17220, 24862, 32504,40146, 47788, 55430 anti-HIV_cap256-119-035165_VR-Chain 1937 9579,17221, 24863, 32505, 40147, 47789, 55431anti-HIV_cap256-119-035109_VR-Chain 1938 9580, 17222, 24864, 32506,40148, 47790, 55432 anti-HIV_cap256-119-033789_VR-Chain 1939 9581,17223, 24865, 32507, 40149, 47791, 55433anti-HIV_cap256-119-033641_VR-Chain 1940 9582, 17224, 24866, 32508,40150, 47792, 55434 anti-HIV_cap256-119-032113_VR-Chain 1941 9583,17225, 24867, 32509, 40151, 47793, 55435anti-HIV_cap256-119-031739_VR-Chain 1942 9584, 17226, 24868, 32510,40152, 47794, 55436 anti-HIV_cap256-119-030932_VR-Chain 1943 9585,17227, 24869, 32511, 40153, 47795, 55437anti-HIV_cap256-119-030740_VR-Chain 1944 9586, 17228, 24870, 32512,40154, 47796, 55438 anti-HIV_cap256-119-030197_VR-Chain 1945 9587,17229, 24871, 32513, 40155, 47797, 55439anti-HIV_cap256-119-027047_VR-Chain 1946 9588, 17230, 24872, 32514,40156, 47798, 55440 anti-HIV_cap256-119-026950_VR-Chain 1947 9589,17231, 24873, 32515, 40157, 47799, 55441anti-HIV_cap256-119-026279_VR-Chain 1948 9590, 17232, 24874, 32516,40158, 47800, 55442 anti-HIV_cap256-119-025355_VR-Chain 1949 9591,17233, 24875, 32517, 40159, 47801, 55443anti-HIV_cap256-119-025301_VR-Chain 1950 9592, 17234, 24876, 32518,40160, 47802, 55444 anti-HIV_cap256-119-025010_VR-Chain 1951 9593,17235, 24877, 32519, 40161, 47803, 55445anti-HIV_cap256-119-024631_VR-Chain 1952 9594, 17236, 24878, 32520,40162, 47804, 55446 anti-HIV_cap256-119-024467_VR-Chain 1953 9595,17237, 24879, 32521, 40163, 47805, 55447anti-HIV_cap256-119-023805_VR-Chain 1954 9596, 17238, 24880, 32522,40164, 47806, 55448 anti-HIV_cap256-119-021736_VR-Chain 1955 9597,17239, 24881, 32523, 40165, 47807, 55449anti-HIV_cap256-119-021203_VR-Chain 1956 9598, 17240, 24882, 32524,40166, 47808, 55450 anti-HIV_cap256-119-020569_VR-Chain 1957 9599,17241, 24883, 32525, 40167, 47809, 55451anti-HIV_cap256-119-019432_VR-Chain 1958 9600, 17242, 24884, 32526,40168, 47810, 55452 anti-HIV_cap256-119-018827_VR-Chain 1959 9601,17243, 24885, 32527, 40169, 47811, 55453anti-HIV_cap256-119-018483_VR-Chain 1960 9602, 17244, 24886, 32528,40170, 47812, 55454 anti-HIV_cap256-119-018118_VR-Chain 1961 9603,17245, 24887, 32529, 40171, 47813, 55455anti-HIV_cap256-119-017782_VR-Chain 1962 9604, 17246, 24888, 32530,40172, 47814, 55456 anti-HIV_cap256-119-017669_VR-Chain 1963 9605,17247, 24889, 32531, 40173, 47815, 55457anti-HIV_cap256-119-016976_VR-Chain 1964 9606, 17248, 24890, 32532,40174, 47816, 55458 anti-HIV_cap256-119-015432_VR-Chain 1965 9607,17249, 24891, 32533, 40175, 47817, 55459anti-HIV_cap256-119-015281_VR-Chain 1966 9608, 17250, 24892, 32534,40176, 47818, 55460 anti-HIV_cap256-119-014957_VR-Chain 1967 9609,17251, 24893, 32535, 40177, 47819, 55461anti-HIV_cap256-119-014777_VR-Chain 1968 9610, 17252, 24894, 32536,40178, 47820, 55462 anti-HIV_cap256-119-014313_VR-Chain 1969 9611,17253, 24895, 32537, 40179, 47821, 55463anti-HIV_cap256-119-014219_VR-Chain 1970 9612, 17254, 24896, 32538,40180, 47822, 55464 anti-HIV_cap256-119-013631_VR-Chain 1971 9613,17255, 24897, 32539, 40181, 47823, 55465anti-HIV_cap256-119-012924_VR-Chain 1972 9614, 17256, 24898, 32540,40182, 47824, 55466 anti-HIV_cap256-119-011793_VR-Chain 1973 9615,17257, 24899, 32541, 40183, 47825, 55467anti-HIV_cap256-119-011413_VR-Chain 1974 9619, 17258, 24900, 32542,40184, 47826, 55468 anti-HIV_cap256-119-011323_VR-Chain 1975 9617,17259, 24901, 32543, 40185, 47827, 55469anti-HIV_cap256-119-011233_VR-Chain 1976 9618, 17260, 24902, 32544,40186, 47828, 55470 anti-HIV_cap256-119-009038_VR-Chain 1977 9619,17261, 24903, 32545, 40187, 47829, 55471anti-HIV_cap256-119-008756_VR-Chain 1978 9620, 17262, 24904, 32546,40188, 47830, 55472 anti-HIV_cap256-119-008055_VR-Chain 1979 9621,17263, 24905, 32547, 40189, 47831, 55473anti-HIV_cap256-119-006949_VR-Chain 1980 9622, 17264, 24906, 32548,40190, 47832, 55474 anti-HIV_cap256-119-006685_VR-Chain 1981 9623,17265, 24907, 32549, 40191, 47833, 55475anti-HIV_cap256-119-006015_VR-Chain 1982 9624, 17266, 24908, 32550,40192, 47834, 55476 anti-HIV_cap256-119-005841_VR-Chain 1983 9625,17267, 24909, 32551, 40193, 47835, 55477anti-HIV_cap256-119-005824_VR-Chain 1984 9626, 17268, 24910, 32552,40194, 47836, 55478 anti-HIV_cap256-119-005494_VR-Chain 1985 9627,17269, 24911, 32553, 40195, 47837, 55479anti-HIV_cap256-119-004949_VR-Chain 1986 9628, 17270, 24912, 32554,40196, 47838, 55480 anti-HIV_cap256-119-004422_VR-Chain 1987 9629,17271, 24913, 32555, 40197, 47839, 55481anti-HIV_cap256-119-003932_VR-Chain 1988 9630, 17272, 24914, 32556,40198, 47840, 55482 anti-HIV_cap256-119-003577_VR-Chain 1989 9631,17273, 24915, 32557, 40199, 47841, 55483anti-HIV_cap256-119-002155_VR-Chain 1990 9632, 17274, 24916, 32558,40200, 47842, 55484 anti-HIV_cap256-119-002017_VR-Chain 1991 9633,17275, 24917, 32559, 40201, 47843, 55485anti-HIV_cap256-119-001312_VR-Chain 1992 9634, 17276, 24918, 32560,40202, 47844, 55486 anti-HIV_cap256-119-001017_VR-Chain 1993 9635,17277, 24919, 32561, 40203, 47845, 55487anti-HIV_cap256-119-000594_VR-Chain 1994 9636, 17278, 24920, 32562,40204, 47846, 55488 anti-HIV_cap256-059-241099_VR-Chain 1995 9637,17279, 24921, 32563, 40205, 47847, 55489anti-HIV_cap256-059-207529_VR-Chain 1996 9638, 17280, 24922, 32564,40206, 47848, 55490 anti-HIV_cap256-059-205541_VR-Chain 1997 9639,17281, 24923, 32565, 40207, 47849, 55491anti-HIV_cap256-059-188439_VR-Chain 1998 9640, 17282, 24924, 32566,40208, 47850, 55492 anti-HIV_cap256-059-187234_VR-Chain 1999 9641,17283, 24925, 32567, 40209, 47851, 55493anti-HIV_cap256-059-187047_VR-Chain 2000 9642, 17284, 24926, 32568,40210, 47852, 55494 anti-HIV_cap256-059-186068_VR-Chain 2001 9643,17285, 24927, 32569, 40211, 47853, 55495anti-HIV_cap256-059-182835_VR-Chain 2002 9644, 17286, 24928, 32570,40212, 47854, 55496 anti-HIV_cap256-059-176659_VR-Chain 2003 9645,17287, 24929, 32571, 40213, 47855, 55497anti-HIV_cap256-059-172956_VR-Chain 2004 9646, 17288, 24930, 32572,40214, 47856, 55498 anti-HIV_cap256-059-171272_VR-Chain 2005 9647,17289, 24931, 32573, 40215, 47857, 55499anti-HIV_cap256-059-168734_VR-Chain 2006 9648, 17290, 24932, 32574,40216, 47858, 55500 anti-HIV_cap256-059-155838_VR-Chain 2007 9649,17291, 24933, 32575, 40217, 47859, 55501anti-HIV_cap256-059-149799_VR-Chain 2008 9650, 17292, 24934, 32576,40218, 47860, 55502 anti-HIV_cap256-059-148168_VR-Chain 2009 9651,17293, 24935, 32577, 40219, 47861, 55503anti-HIV_cap256-059-144685_VR-Chain 2010 9652, 17294, 24936, 32578,40220, 47862, 55504 anti-HIV_cap256-059-140017_VR-Chain 2011 9653,17295, 24937, 32579, 40221, 47863, 55505anti-HIV_cap256-059-137547_VR-Chain 2012 9654, 17296, 24938, 32580,40222, 47864, 55506 anti-HIV_cap256-059-131908_VR-Chain 2013 9655,17297, 24939, 32581, 40223, 47865, 55507anti-HIV_cap256-059-116006_VR-Chain 2014 9656, 17298, 24940, 32582,40224, 47866, 55508 anti-HIV_cap256-059-115783_VR-Chain 2015 9657,17299, 24941, 32583, 40225, 47867, 55509anti-HIV_cap256-059-114609_VR-Chain 2016 9658, 17300, 24942, 32584,40226, 47868, 55510 anti-HIV_cap256-059-113952_VR-Chain 2017 9659,17301, 24943, 32585, 40227, 47869, 55511anti-HIV_cap256-059-113878_VR-Chain 2018 9660, 17302, 24944, 32586,40228, 47870, 55512 anti-HIV_cap256-059-113622_VR-Chain 2019 9661,17303, 24945, 32587, 40229, 47871, 55513anti-HIV_cap256-059-109427_VR-Chain 2020 9662, 17304, 24946, 32588,40230, 47872, 55514 anti-HIV_cap256-059-109081_VR-Chain 2021 9663,17305, 24947, 32589, 40231, 47873, 55515anti-HIV_cap256-059-107590_VR-Chain 2022 9664, 17306, 24948, 32590,40232, 47874, 55516 anti-HIV_cap256-059-107504_VR-Chain 2023 9665,17307, 24949, 32591, 40233, 47875, 55517anti-HIV_cap256-059-099614_VR-Chain 2024 9666, 17308, 24950, 32592,40234, 47876, 55518 anti-HIV_cap256-059-098972_VR-Chain 2025 9667,17309, 24951, 32593, 40235, 47877, 55519anti-HIV_cap256-059-097236_VR-Chain 2026 9668, 17310, 24952, 32594,40236, 47878, 55520 anti-HIV_cap256-059-091487_VR-Chain 2027 9669,17311, 24953, 32595, 40237, 47879, 55521anti-HIV_cap256-059-089812_VR-Chain 2028 9670, 17312, 24954, 32596,40238, 47880, 55522 anti-HIV_cap256-059-088468_VR-Chain 2029 9671,17313, 24955, 32597, 40239, 47881, 55523anti-HIV_cap256-059-088341_VR-Chain 2030 9672, 17314, 24956, 32598,40240, 47882, 55524 anti-HIV_cap256-059-086533_VR-Chain 2031 9673,17315, 24957, 32599, 40241, 47883, 55525anti-HIV_cap256-059-086043_VR-Chain 2032 9674, 17316, 24958, 32600,40242, 47884, 55526 anti-HIV_cap256-059-084191_VR-Chain 2033 9675,17317, 24959, 32601, 40243, 47885, 55527anti-HIV_cap256-059-082135_VR-Chain 2034 9676, 17318, 24960, 32602,40244, 47886, 55528 anti-HIV_cap256-059-079417_VR-Chain 2035 9677,17319, 24961, 32603, 40245, 47887, 55529anti-HIV_cap256-059-076027_VR-Chain 2036 9678, 17320, 24962, 32604,40246, 47888, 55530 anti-HIV_cap256-059-075082_VR-Chain 2037 9679,17321, 24963, 32605, 40247, 47889, 55531anti-HIV_cap256-059-072575_VR-Chain 2038 9680, 17322, 24964, 32606,40248, 47890, 55532 anti-HIV_cap256-059-071926_VR-Chain 2039 9681,17323, 24965, 32607, 40249, 47891, 55533anti-HIV_cap256-059-069638_VR-Chain 2040 9682, 17324, 24966, 32608,40250, 47892, 55534 anti-HIV_cap256-059-069165_VR-Chain 2041 9683,17325, 24967, 32609, 40251, 47893, 55535anti-HIV_cap256-059-068956_VR-Chain 2042 9684, 17326, 24968, 32610,40252, 47894, 55536 anti-HIV_cap256-059-068876_VR-Chain 2043 9685,17327, 24969, 32611, 40253, 47895, 55537anti-HIV_cap256-059-067733_VR-Chain 2044 9686, 17328, 24970, 32612,40254, 47896, 55538 anti-HIV_cap256-059-067450_VR-Chain 2045 9687,17329, 24971, 32613, 40255, 47897, 55539anti-HIV_cap256-059-065694_VR-Chain 2046 9688, 17330, 24972, 32614,40256, 47898, 55540 anti-HIV_cap256-059-065109_VR-Chain 2047 9689,17331, 24973, 32615, 40257, 47899, 55541anti-HIV_cap256-059-065060_VR-Chain 2048 9690, 17332, 24974, 32616,40258, 47900, 55542 anti-HIV_cap256-059-064001_VR-Chain 2049 9691,17333, 24975, 32617, 40256, 47901, 55543anti-HIV_cap256-059-063270_VR-Chain 2050 9692, 17334, 24976, 32618,40260, 47902, 55544 anti-HIV_cap256-059-061357_VR-Chain 2051 9693,17335, 24977, 32619, 40261, 47903, 55545anti-HIV_cap256-059-059834_VR-Chain 2052 9694, 17336, 24978, 32620,40262, 47904, 55546 anti-HIV_cap256-059-059313_VR-Chain 2053 9695,17337, 24979, 32621, 40263, 47905, 55547anti-HIV_cap256-059-057130_VR-Chain 2054 9696, 17338, 24980, 32622,40264, 47906, 55548 anti-HIV_cap256-059-050520_VR-Chain 2055 9697,17339, 24981, 32623, 40265, 47907, 55549anti-HIV_cap256-059-049839_VR-Chain 2056 9698, 17340, 24982, 32624,40266, 47908, 55550 anti-HIV_cap256-059-048503_VR-Chain 2057 9699,17341, 24983, 32625, 40267, 47909, 55551anti-HIV_cap256-059-045516_VR-Chain 2058 9700, 17342, 24984, 32626,40268, 47910, 55552 anti-HIV_cap256-059-044188_VR-Chain 2059 9701,17343, 24985, 32627, 40269, 47911, 55553anti-HIV_cap256-059-044105_VR-Chain 2060 9702, 17344, 24986, 32628,40270, 47912, 55554 anti-HIV_cap256-059-042100_VR-Chain 2061 9703,17345, 24987, 32629, 40271, 47913, 55555anti-HIV_cap256-059-040742_VR-Chain 2062 9704, 17346, 24988, 32630,40272, 47914, 55556 anti-HIV_cap256-059-040554_VR-Chain 2063 9705,17347, 24989, 32631, 40273, 47915, 55557anti-HIV_cap256-059-039660_VR-Chain 2064 9706, 17348, 24990, 32632,40274, 47916, 55558 anti-HIV_cap256-059-039298_VR-Chain 2065 9707,17349, 24991, 32633, 40275, 47917, 55559anti-HIV_cap256-059-037873_VR-Chain 2066 9708, 17350, 24992, 32634,40276, 47918, 55560 anti-HIV_cap256-059-037633_VR-Chain 2067 9709,17351, 24993, 32635, 40277, 47919, 55561anti-HIV_cap256-059-036817_VR-Chain 2068 9710, 17352, 24994, 32636,40278, 47920, 55562 anti-HIV_cap256-059-032787_VR-Chain 2069 9711,17353, 24995, 32637, 40279, 47921, 55563anti-HIV_cap256-059-032427_VR-Chain 2070 9712, 17354, 24996, 32638,40280, 47922, 55564 anti-HIV_cap256-059-029390_VR-Chain 2071 9713,17355, 24997, 32639, 40281, 47923, 55565anti-HIV_cap256-059-027877_VR-Chain 2072 9714, 17356, 24998, 32640,40282, 47924, 55566 anti-HIV_cap256-059-026640_VR-Chain 2073 9715,17357, 24999, 32641, 40283, 47925, 55567anti-HIV_cap256-059-026017_VR-Chain 2074 9716, 17358, 25000, 32642,40284, 47926, 55568 anti-HIV_cap256-059-024100_VR-Chain 2075 9717,17359, 25001, 32643, 40285, 47927, 55569anti-HIV_cap256-059-023966_VR-Chain 2076 9718, 17360, 25002, 32644,40286, 47928, 55570 anti-HIV_cap256-059-020534_VR-Chain 2077 9719,17361, 25003, 32645, 40287, 47929, 55571anti-HIV_cap256-059-019513_VR-Chain 2078 9720, 17362, 25004, 32646,40288, 47930, 55572 anti-HIV_cap256-059-012963_VR-Chain 2079 9721,17363, 25005, 32647, 40289, 47931, 55573anti-HIV_cap256-059-010396_VR-Chain 2080 9722, 17364, 25006, 32648,40290, 47932, 55574 anti-HIV_cap256-059-008136_VR-Chain 2081 9723,17365, 25007, 32649, 40291, 47933, 55575anti-HIV_cap256-059-006147_VR-Chain 2082 9724, 17366, 25008, 32650,40292, 47934, 55576 anti-HIV_cap256-059-005081_VR-Chain 2083 9725,17367, 25009, 32651, 40293, 47935, 55577anti-HIV_cap256-059-005006_VR-Chain 2084 9726, 17368, 25010, 32652,40294, 47936, 55578 anti-HIV_cap256-059-004451_VR-Chain 2085 9727,17369, 25011, 32653, 40295, 47937, 55579anti-HIV_cap256-059-003571_VR-Chain 2086 9728, 17370, 25012, 32654,40296, 47938, 55580 anti-HIV_cap256-059-003449_VR-Chain 2087 9729,17371, 25013, 32655, 40297, 47939, 55581anti-HIV_cap256-059-002712_VR-Chain 2088 9730, 17372, 25014, 32656,40298, 47940, 55582 anti-HIV_cap256-059-001573_VR-Chain 2089 9731,17373, 25015, 32657, 40299, 47941, 55583anti-HIV_cap256-059-001379_VR-Chain 2090 9732, 17374, 25016, 32658,40300, 47942, 55584 anti-HIV_cap256-059-001029_VR-Chain 2091 9733,17375, 25017, 32659, 40301, 47943, 55585anti-HIV_cap256-048-165087_VR-Chain 2092 9734, 17376, 25018, 32660,40302, 47944, 55586 anti-HIV_cap256-048-158861_VR-Chain 2093 9735,17377, 25019, 32661, 40303, 47945, 55587anti-HIV_cap256-048-158280_VR-Chain 2094 9736, 17378, 25020, 32662,40304, 47946, 55588 anti-HIV_cap256-048-157928_VR-Chain 2095 9737,17379, 25021, 32663, 40305, 47947, 55589anti-HIV_cap256-048-157056_VR-Chain 2096 9738, 17380, 25022, 32664,40306, 47948, 55590 anti-HIV_cap256-048-156422_VR-Chain 2097 9739,17381, 25023, 32665, 40307, 47949, 55591anti-HIV_cap256-048-152863_VR-Chain 2098 9740, 17382, 25024, 32666,40308, 47950, 55592 anti-HIV_cap256-048-152770_VR-Chain 2099 9741,17383, 25025, 32667, 40309, 47951, 55593anti-HIV_cap256-048-150027_VR-Chain 2100 9742, 17384, 25026, 32668,40310, 47952, 55594 anti-HIV_cap256-048-148246_VR-Chain 2101 9743,17385, 25027, 32669, 40311, 47953, 55595anti-HIV_cap256-048-147428_VR-Chain 2102 9744, 17386, 25028, 32670,40312, 47954, 55596 anti-HIV_cap256-048-146603_VR-Chain 2103 9745,17387, 25029, 32671, 40313, 47955, 55597anti-HIV_cap256-048-145735_VR-Chain 2104 9746, 17388, 25030, 32672,40314, 47956, 55598 anti-HIV_cap256-048-145116_VR-Chain 2105 9747,17389, 25031, 32673, 40315, 47957, 55599anti-HIV_cap256-048-144077_VR-Chain 2106 9748, 17390, 25032, 32674,40316, 47958, 55600 anti-HIV_cap256-048-142876_VR-Chain 2107 9749,17391, 25033, 32675, 40317, 47959, 55601anti-HIV_cap256-048-140582_VR-Chain 2108 9750, 17392, 25034, 32676,40318, 47960, 55602 anti-HIV_cap256-048-139355_VR-Chain 2109 9751,17393, 25035, 32677, 40319, 47961, 55603anti-HIV_cap256-048-139151_VR-Chain 2110 9752, 17394, 25036, 32678,40320, 47962, 55604 anti-HIV_cap256-048-137672_VR-Chain 2111 9753,17395, 25037, 32679, 40321, 47963, 55605anti-HIV_cap256-048-137506_VR-Chain 2112 9754, 17396, 25038, 32680,40322, 47964, 55606 anti-HIV_cap256-048-137270_VR-Chain 2113 9755,17397, 25039, 32681, 40323, 47965, 55607anti-HIV_cap256-048-135447_VR-Chain 2114 9756, 17398, 25040, 32682,40324, 47966, 55608 anti-HIV_cap256-048-131966_VR-Chain 2115 9757,17399, 25041, 32683, 40325, 47967, 55609anti-HIV_cap256-048-131008_VR-Chain 2116 9758, 17400, 25042, 32684,40326, 47968, 55610 anti-HIV_cap256-048-129369_VR-Chain 2117 9759,17401, 25043, 32685, 40327, 47969, 55611anti-HIV_cap256-048-128476_VR-Chain 2118 9760, 17402, 25044, 32686,40328, 47970, 55612 anti-HIV_cap256-048-128270_VR-Chain 2119 9761,17403, 25045, 32687, 40329, 47971, 55613anti-HIV_cap256-048-126220_VR-Chain 2120 9762, 17404, 25046, 32688,40330, 47972, 55614 anti-HIV_cap256-048-125713_VR-Chain 2121 9763,17405, 25047, 32689, 40331, 47973, 55615anti-HIV_cap256-048-123934_VR-Chain 2122 9764, 17406, 25048, 32690,40332, 47974, 55616 anti-HIV_cap256-048-122673_VR-Chain 2123 9765,17407, 25049, 32691, 40333, 47975, 55617anti-HIV_cap256-048-122208_VR-Chain 2124 9796, 17408, 25050, 32692,40334, 47976, 55618 anti-HIV_cap256-048-121552_VR-Chain 2125 9767,17409, 25051, 32693, 40335, 47977, 55619anti-HIV_cap256-048-120643_VR-Chain 2126 9768, 17410, 25052, 32694,40336, 47978, 55620 anti-HIV_cap256-048-118458_VR-Chain 2127 9769,17411, 25053, 32695, 40337, 47979, 55621anti-HIV_cap256-048-118112_VR-Chain 2128 9770, 17412, 25054, 32696,40338, 47980, 55622 anti-HIV_cap256-048-116469_VR-Chain 2129 9771,17413, 25055, 32697, 40339, 47981, 55623anti-HIV_cap256-048-113917_VR-Chain 2130 9772, 17414, 25056, 32698,40340, 47982, 55624 anti-HIV_cap256-048-112368_VR-Chain 2131 9773,17415, 25057, 32699, 40341, 47983, 55625anti-HIV_cap256-048-112047_VR-Chain 2132 9774, 17416, 25058, 32700,40342, 47984, 55626 anti-HIV_cap256-048-112029_VR-Chain 2133 9775,17417, 25059, 32701, 40343, 47985, 55627anti-HIV_cap256-048-110957_VR-Chain 2134 9776, 17418, 25060, 32702,40344, 47986, 55628 anti-HIV_cap256-048-110526_VR-Chain 2135 9777,17419, 25061, 32703, 40345, 47987, 55629anti-HIV_cap256-048-109336_VR-Chain 2136 9778, 17420, 25062, 32704,40346, 47988, 55630 anti-HIV_cap256-048-108152_VR-Chain 2137 9779,17421, 25063, 32705, 40347, 47989, 55631anti-HIV_cap256-048-107799_VR-Chain 2138 9780, 17422, 25064, 32706,40348, 47990, 55632 anti-HIV_cap256-048-107384_VR-Chain 2139 9781,17423, 25065, 32707, 40349, 47991, 55633anti-HIV_cap256-048-106530_VR-Chain 2140 9782, 17424, 25066, 32708,40350, 47992, 55634 anti-HIV_cap256-048-106464_VR-Chain 2141 9783,17425, 25067, 32709, 40351, 47993, 55635anti-HIV_cap256-048-106411_VR-Chain 2142 9784, 17426, 25068, 32710,40352, 47994, 55636 anti-HIV_cap256-048-106306_VR-Chain 2143 9785,17427, 25069, 32711, 40353, 47995, 55637anti-HIV_cap256-048-104496_VR-Chain 2144 9786, 17428, 25070, 32712,40354, 47996, 55638 anti-HIV_cap256-048-103074_VR-Chain 2145 9787,17429, 25071, 32713, 40355, 47997, 55639anti-HIV_cap256-048-100832_VR-Chain 2146 9788, 17430, 25072, 32714,40356, 47998, 55640 anti-HIV_cap256-048-100188_VR-Chain 2147 9789,17431, 25073, 32715, 40357, 47999, 55641anti-HIV_cap256-048-099645_VR-Chain 2148 9790, 17432, 25074, 32716,40358, 48000, 55642 anti-HIV_cap256-048-098137_VR-Chain 2149 9791,17433, 25075, 32717, 40359, 48001, 55643anti-HIV_cap256-048-097878_VR-Chain 2150 9792, 17434, 25076, 32718,40360, 48002, 55644 anti-HIV_cap256-048-097510_VR-Chain 2151 9793,17435, 25077, 32719, 40361, 48003, 55645anti-HIV_cap256-048-097313_VR-Chain 2152 9794, 17436, 25078, 32720,40362, 48004, 55646 anti-HIV_cap256-048-096626_VR-Chain 2153 9795,17437, 25079, 32721, 40363, 48005, 55647anti-HIV_cap256-048-096483_VR-Chain 2154 9796, 17438, 25080, 32722,40364, 48006, 55648 anti-HIV_cap256-048-095691_VR-Chain 2155 9797,17439, 25081, 32723, 40365, 48007, 55649anti-HIV_cap256-048-095525_VR-Chain 2156 9798, 17440, 25082, 32724,40366, 48008, 55650 anti-HIV_cap256-048-094783_VR-Chain 2157 9799,17441, 25083, 32725, 40367, 48009, 55651anti-HIV_cap256-048-094356_VR-Chain 2158 9800, 17442, 25084, 32726,40368, 48010, 55652 anti-HIV_cap256-048-090756_VR-Chain 2159 9801,17443, 25085, 32727, 40369, 48011, 55653anti-HIV_cap256-048-089065_VR-Chain 2160 9802, 17444, 25086, 32728,40370, 48012, 55654 anti-HIV_cap256-048-084986_VR-Chain 2161 9803,17445, 25087, 32729, 40371, 48013, 55655anti-HIV_cap256-048-083355_VR-Chain 2162 9804, 17446, 25088, 32730,40372, 48014, 55656 anti-HIV_cap256-048-082462_VR-Chain 2163 9805,17447, 25089, 32731, 40373, 48015, 55657anti-HIV_cap256-048-082246_VR-Chain 2164 9806, 17448, 25090, 32732,40374, 48016, 55658 anti-HIV_cap256-048-080752_VR-Chain 2165 9807,17449, 25091, 32733, 40375, 48017, 55659anti-HIV_cap256-048-078409_VR-Chain 2166 9808, 17450, 25092, 32734,40376, 48018, 55660 anti-HIV_cap256-048-078273_VR-Chain 2167 9809,17451, 25093, 32735, 40377, 48019, 55661anti-HIV_cap256-048-078062_VR-Chain 2168 9810, 17452, 25094, 32736,40378, 48020, 55662 anti-HIV_cap256-048-077798_VR-Chain 2169 9811,17453, 25095, 32737, 40379, 48021, 55663anti-HIV_cap256-048-073853_VR-Chain 2170 9812, 17454, 25096, 32738,40380, 48022, 55664 anti-HIV_cap256-048-071661_VR-Chain 2171 9813,17455, 25097, 32739, 40381, 48023, 55665anti-HIV_cap256-048-071360_VR-Chain 2172 9814, 17456, 25098, 32740,40382, 48024, 55666 anti-HIV_cap256-048-070955_VR-Chain 2173 9815,17457, 25099, 32741, 40383, 48025, 55667anti-HIV_cap256-048-070061_VR-Chain 2174 9816, 17458, 25100, 32742,40384, 48026, 55668 anti-HIV_cap256-048-069669_VR-Chain 2175 9817,17459, 25101, 32743, 40385, 48027, 55669anti-HIV_cap256-048-069205_VR-Chain 2176 9818, 17460, 25102, 32744,40386, 48028, 55670 anti-HIV_cap256-048-068882_VR-Chain 2177 9819,17461, 25103, 32745, 40387, 48029, 55671anti-HIV_cap256-048-067764_VR-Chain 2178 9820, 17462, 25104, 32746,40388, 48030, 55672 anti-HIV_cap256-048-066845_VR-Chain 2179 9821,17463, 25105, 32747, 40389, 48031, 55673anti-HIV_cap256-048-065226_VR-Chain 2180 9822, 17464, 25106, 32748,40390, 48032, 55674 anti-HIV_cap256-048-063717_VR-Chain 2181 9823,17465, 25107, 32749, 40391, 48033, 55675anti-HIV_cap256-048-063150_VR-Chain 2182 9824, 17466, 25108, 32750,40392, 48034, 55676 anti-HIV_cap256-048-062431_VR-Chain 2183 9825,17467, 25109, 32751, 40393, 48035, 55677anti-HIV_cap256-048-060745_VR-Chain 2184 9826, 17468, 25110, 32752,40394, 48036, 55678 anti-HIV_cap256-048-060420_VR-Chain 2185 9827,17469, 25111, 32753, 40395, 48037, 55679anti-HIV_cap256-048-060014_VR-Chain 2186 9828, 17470, 25112, 32754,40396, 48038, 55680 anti-HIV_cap256-048-059747_VR-Chain 2187 9829,17471, 25113, 32755, 40397, 48039, 55681anti-HIV_cap256-048-058393_VR-Chain 2188 9830, 17472, 25114, 32756,40398, 48040, 55682 anti-HIV_cap256-048-058159_VR-Chain 2189 9831,17473, 25115, 32757, 40399, 48041, 55683anti-HIV_cap256-048-057127_VR-Chain 2190 9832, 17474, 25116, 32758,40400, 48042, 55684 anti-HIV_cap256-048-056251_VR-Chain 2191 9833,17475, 25117, 32759, 40401, 48043, 55685anti-HIV_cap256-048-055421_VR-Chain 2192 9834, 17476, 25118, 32760,40402, 48044, 55686 anti-HIV_cap256-048-054989_VR-Chain 2193 9835,17477, 25119, 32761, 40403, 48045, 55687anti-HIV_cap256-048-054759_VR-Chain 2194 9836, 17478, 25120, 32762,40404, 48046, 55688 anti-HIV_cap256-048-052573_VR-Chain 2195 9837,17479, 25121, 32763, 40405, 48047, 55689anti-HIV_cap256-048-051477_VR-Chain 2196 9838, 17480, 25122, 32764,40406, 48048, 55690 anti-HIV_cap256-048-051299_VR-Chain 2197 9839,17481, 25123, 32765, 40407, 48049, 55691anti-HIV_cap256-048-050815_VR-Chain 2198 9840, 17482, 25124, 32766,40408, 48050, 55692 anti-HIV_cap256-048-049884_VR-Chain 2199 9841,17483, 25125, 32767, 40409, 48051, 55693anti-HIV_cap256-048-049170_VR-Chain 2200 9842, 17484, 25126, 32768,40410, 48052, 55694 anti-HIV_cap256-048-048531_VR-Chain 2201 9843,17485, 25127, 32769, 40411, 48053, 55695anti-HIV_cap256-048-048259_VR-Chain 2202 9844, 17486, 25128, 32770,40412, 48054, 55696 anti-HIV_cap256-048-047313_VR-Chain 2203 9845,17487, 25129, 32771, 40413, 48055, 55697anti-HIV_cap256-048-046596_VR-Chain 2204 9846, 17488, 25130, 32772,40414, 48056, 55698 anti-HIV_cap256-048-044781_VR-Chain 2205 9847,17489, 25131, 32773, 40415, 48057, 55699anti-HIV_cap256-048-042599_VR-Chain 2206 9848, 17490, 25132, 32774,40416, 48058, 55700 anti-HIV_cap256-048-041276_VR-Chain 2207 9849,17491, 25133, 32775, 40417, 48059, 55701anti-HIV_cap256-048-040200_VR-Chain 2208 9850, 17492, 25134, 32776,40418, 48060, 55702 anti-HIV_cap256-048-039061_VR-Chain 2209 9851,17493, 25135, 32777, 40419, 48061, 55703anti-HIV_cap256-048-038515_VR-Chain 2210 9852, 17494, 25136, 32778,40420, 48062, 55704 anti-HIV_cap256-048-038255_VR-Chain 2211 9853,17495, 25137, 32779, 40421, 48063, 55705anti-HIV_cap256-048-038177_VR-Chain 2212 9854, 17496, 25138, 32780,40422, 48064, 55706 anti-HIV_cap256-048-035513_VR-Chain 2213 9855,17497, 25139, 32781, 40423, 48065, 55707anti-HIV_cap256-048-034112_VR-Chain 2214 9856, 17498, 25140, 32782,40424, 48066, 55708 anti-HIV_cap256-048-033983_VR-Chain 2215 9857,17499, 25141, 32783, 40425, 48067, 55709anti-HIV_cap256-048-032688_VR-Chain 2216 9858, 17500, 25142, 32784,40426, 48068, 55710 anti-HIV_cap256-048-031092_VR-Chain 2217 9859,17501, 25143, 32785, 40427, 48069, 55711anti-HIV_cap256-048-030464_VR-Chain 2218 9860, 17502, 25144, 32786,40428, 48070, 55712 anti-HIV_cap256-048-030289_VR-Chain 2219 9861,17503, 25145, 32787, 40429, 48071, 55713anti-HIV_cap256-048-030261_VR-Chain 2220 9862, 17504, 25146, 32788,40430, 48072, 55714 anti-HIV_cap256-048-029362_VR-Chain 2221 9863,17505, 25147, 32789, 40431, 48073, 55715anti-HIV_cap256-048-027638_VR-Chain 2222 9864, 17506, 25148, 32790,40432, 48074, 55716 anti-HIV_cap256-048-027613_VR-Chain 2223 9865,17507, 25149, 32791, 40433, 48075, 55717anti-HIV_cap256-048-026627_VR-Chain 2224 9866, 17508, 25150, 32792,40434, 48076, 55718 anti-HIV_cap256-048-026239_VR-Chain 2225 9867,17509, 25151, 32793, 40435, 48077, 55719anti-HIV_cap256-048-025518_VR-Chain 2226 9868, 17510, 25152, 32794,40436, 48078, 55720 anti-HIV_cap256-048-024854_VR-Chain 2227 9869,17511, 25153, 32795, 40437, 48079, 55721anti-HIV_cap256-048-024537_VR-Chain 2228 9870, 17512, 25154, 32796,40438, 48080, 55722 anti-HIV_cap256-048-021781_VR-Chain 2229 9871,17513, 25155, 32797, 40439, 48081, 55723anti-HIV_cap256-048-021758_VR-Chain 2230 9872, 17514, 25156, 32798,40440, 48082, 55724 anti-HIV_cap256-048-020988_VR-Chain 2231 9873,17515, 25157, 32799, 40441, 48083, 55725anti-HIV_cap256-048-020663_VR-Chain 2232 9874, 17516, 25158, 32800,40442, 48084, 55726 anti-HIV_cap256-048-020590_VR-Chain 2233 9875,17517, 25159, 32801, 40443, 48085, 55727anti-HIV_cap256-048-019765_VR-Chain 2234 9876, 17518, 25160, 32802,40444, 48086, 55728 anti-HIV_cap256-048-019254_VR-Chain 2235 9877,17519, 25161, 32803, 40445, 48087, 55729anti-HIV_cap256-048-018073_VR-Chain 2236 9878, 17520, 25162, 32804,40446, 48088, 55730 anti-HIV_cap256-048-016775_VR-Chain 2237 9879,17521, 25163, 32805, 40447, 48089, 55731anti-HIV_cap256-048-016069_VR-Chain 2238 9880, 17522, 25164, 32806,40448, 48090, 55732 anti-HIV_cap256-048-015867_VR-Chain 2239 9881,17523, 25165, 32807, 40449, 48091, 55733anti-HIV_cap256-048-015673_VR-Chain 2240 9882, 17524, 25166, 32808,40450, 48092, 55734 anti-HIV_cap256-048-015156_VR-Chain 2241 9883,17525, 25167, 32809, 40451, 48093, 55735anti-HIV_cap256-048-014521_VR-Chain 2242 9884, 17526, 25168, 32810,40452, 48094, 55736 anti-HIV_cap256-048-014475_VR-Chain 2243 9885,17527, 25169, 32811, 40453, 48095, 55737anti-HIV_cap256-048-013798_VR-Chain 2244 9886, 17528, 25170, 32812,40454, 48096, 55738 anti-HIV_cap256-048-013271_VR-Chain 2245 9887,17529, 25171, 32813, 40455, 48097, 55739anti-HIV_cap256-048-013180_VR-Chain 2246 9888, 17530, 25172, 32814,40456, 48098, 55740 anti-HIV_cap256-048-012148_VR-Chain 2247 9889,17531, 25173, 32815, 40457, 48099, 55741anti-HIV_cap256-048-011870_VR-Chain 2248 9890, 17532, 25174, 32816,40458, 48100, 55742 anti-HIV_cap256-048-011530_VR-Chain 2249 9891,17533, 25175, 32817, 40459, 48101, 55743anti-HIV_cap256-048-010968_VR-Chain 2250 9892, 17534, 25176, 32818,40460, 48102, 55744 anti-HIV_cap256-048-010224_VR-Chain 2251 9893,17535, 25177, 32819, 40461, 48103, 55745anti-HIV_cap256-048-009749_VR-Chain 2252 9894, 17536, 25178, 32820,40462, 48104, 55746 anti-HIV_cap256-048-009623_VR-Chain 2253 9895,17537, 25179, 32821, 40463, 48105, 55747anti-HIV_cap256-048-008234_VR-Chain 2254 9896, 17538, 25180, 32822,40464, 48106, 55748 anti-HIV_cap256-048-008149_VR-Chain 2255 9897,17539, 25181, 32823, 40465, 48107, 55749anti-HIV_cap256-048-007301_VR-Chain 2256 9898, 17540, 25182, 32824,40466, 48108, 55750 anti-HIV_cap256-048-007174_VR-Chain 2257 9899,17541, 25183, 32825, 40467, 48109, 55751anti-HIV_cap256-048-007079_VR-Chain 2258 9900, 17542, 25184, 32826,40468, 48110, 55752 anti-HIV_cap256-048-007033_VR-Chain 2259 9901,17543, 25185, 32827, 40469, 48111, 55753anti-HIV_cap256-048-006128_VR-Chain 2260 9902, 17544, 25186, 32828,40470, 48112, 55754 anti-HIV_cap256-048-005999_VR-Chain 2261 9903,17545, 25187, 32829, 40471, 48113, 55755anti-HIV_cap256-048-005394_VR-Chain 2262 9904, 17546, 25188, 32830,40472, 48114, 55756 anti-HIV_cap256-048-004226_VR-Chain 2263 9905,17547, 25189, 32831, 40473, 48115, 55757anti-HIV_cap256-048-004097_VR-Chain 2264 9906, 17548, 25190, 32832,40474, 48116, 55758 anti-HIV_cap256-048-003289_VR-Chain 2265 9907,17549, 25191, 32833, 40475, 48117, 55759anti-HIV_cap256-048-002601_VR-Chain 2266 9908, 17550, 25192, 32834,40476, 48118, 55760 anti-HIV_cap256-048-002129_VR-Chain 2267 9909,17551, 25193, 32835, 40477, 48119, 55761anti-HIV_cap256-048-001875_VR-Chain 2268 9910, 17552, 25194, 32836,40478, 48120, 55762 anti-HIV_cap256-048-001302_VR-Chain 2269 9911,17553, 25195, 32837, 40479, 48121, 55763anti-HIV_cap256-048-001203_VR-Chain 2270 9912, 17554, 25196, 32838,40480, 48122, 55764 anti-HIV_cap256-048-000383_VR-Chain 2271 9913,17555, 25197, 32839, 40481, 48123, 55765anti-HIV_cap256-038-261791_VR-Chain 2272 9914, 17556, 25198, 32840,40482, 48124, 55766 anti-HIV_cap256-038-241540_VR-Chain 2273 9915,17557, 25199, 32841, 40483, 48125, 55767anti-HIV_cap256-038-235677_VR-Chain 2274 9916, 17558, 25200, 32842,40484, 48126, 55768 anti-HIV_cap256-038-234314_VR-Chain 2275 9917,17559, 25201, 32843, 40485, 48127, 55769anti-HIV_cap256-038-234273_VR-Chain 2276 9918, 17560, 25202, 32844,40486, 48128, 55770 anti-HIV_cap256-038-223164_VR-Chain 2277 9919,17561, 25203, 32845, 40487, 48129, 55771anti-HIV_cap256-038-220289_VR-Chain 2278 9920, 17562, 25204, 32846,40488, 48130, 55772 anti-HIV_cap256-038-220020_VR-Chain 2279 9921,17563, 25205, 32847, 40489, 48131, 55773anti-HIV_cap256-038-216853_VR-Chain 2280 9922, 17564, 25206, 32848,40490, 48132, 55774 anti-HIV_cap256-038-213466_VR-Chain 2281 9923,17565, 25207, 32849, 40491, 48133, 55775anti-HIV_cap256-038-213212_VR-Chain 2282 9924, 17566, 25208, 32850,40492, 48134, 55776 anti-HIV_cap256-038-213120_VR-Chain 2283 9925,17567, 25209, 32851, 40493, 48135, 55777anti-HIV_cap256-038-212592_VR-Chain 2284 9926, 17568, 25210, 32852,40494, 48136, 55778 anti-HIV_cap256-038-211790_VR-Chain 2285 9927,17569, 25211, 32853, 40495, 48137, 55779anti-HIV_cap256-038-209916_VR-Chain 2286 9928, 17570, 25212, 32854,40496, 48138, 55780 anti-HIV_cap256-038-207938_VR-Chain 2287 9929,17571, 25213, 32855, 40497, 48139, 55781anti-HIV_cap256-038-202245_VR-Chain 2288 9930, 17572, 25214, 32856,40498, 48140, 55782 anti-HIV_cap256-038-197721_VR-Chain 2289 9931,17573, 25215, 32857, 40499, 48141, 55783anti-HIV_cap256-038-196679_VR-Chain 2290 9932, 17574, 25216, 32858,40500, 48142, 55784 anti-HIV_cap256-038-196118_VR-Chain 2291 9933,17575, 25217, 32859, 40501, 48143, 55785anti-HIV_cap256-038-195382_VR-Chain 2292 9934, 17576, 25218, 32860,40502, 48144, 55786 anti-HIV_cap256-038-180001_VR-Chain 2293 9935,17577, 25219, 32861, 40503, 48145, 55787anti-HIV_cap256-038-178021_VR-Chain 2294 9936, 17578, 25220, 32862,40504, 48146, 55788 anti-HIV_cap256-038-177104_VR-Chain 2295 9937,17579, 25221, 32863, 40505, 48147, 55789anti-HIV_cap256-038-171261_VR-Chain 2296 9938, 17580, 25222, 32864,40506, 48148, 55790 anti-HIV_cap256-038-169090_VR-Chain 2297 9939,17581, 25223, 32865, 40507, 48149, 55791anti-HIV_cap256-038-168705_VR-Chain 2298 9940, 17582, 25224, 32866,40508, 48150, 55792 anti-HIV_cap256-038-167685_VR-Chain 2299 9941,17583, 25225, 32867, 40509, 48151, 55793anti-HIV_cap256-038-158775_VR-Chain 2300 9942, 17584, 25226, 32868,40510, 48152, 55794 anti-HIV_cap256-038-157318_VR-Chain 2301 9943,17585, 25227, 32869, 40511, 48153, 55795anti-HIV_cap256-038-153058_VR-Chain 2302 9944, 17586, 25228, 32870,40512, 48154, 55796 anti-HIV_cap256-038-150027_VR-Chain 2303 9945,17587, 25229, 32871, 40513, 48155, 55797anti-HIV_cap256-038-146372_VR-Chain 2304 9946, 17588, 25230, 32872,40514, 48156, 55798 anti-HIV_cap256-038-141868_VR-Chain 2305 9947,17589, 25231, 32873, 40515, 48157, 55799anti-HIV_cap256-038-141616_VR-Chain 2306 9948, 17590, 25232, 32874,40516, 48158, 55800 anti-HIV_cap256-038-127989_VR-Chain 2307 9949,17591, 25233, 32875, 40517, 48159, 55801anti-HIV_cap256-038-118109_VR-Chain 2308 9950, 17592, 25234, 32876,40518, 48160, 55802 anti-HIV_cap256-038-112226_VR-Chain 2309 9951,17593, 25235, 32877, 40519, 48161, 55803anti-HIV_cap256-038-105918_VR-Chain 2310 9952, 17594, 25236, 32878,40520, 48162, 55804 anti-HIV_cap256-038-104487_VR-Chain 2311 9953,17595, 25237, 32879, 40521, 48163, 55805anti-HIV_cap256-038-102308_VR-Chain 2312 9954, 17596, 25238, 32880,40522, 48164, 55806 anti-HIV_cap256-038-091115_VR-Chain 2313 9955,17597, 25239, 32881, 40523, 48165, 55807anti-HIV_cap256-038-090262_VR-Chain 2314 9956, 17598, 25240, 32882,40524, 48166, 55808 anti-HIV_cap256-038-083260_VR-Chain 2315 9957,17599, 25241, 32883, 40525, 48167, 55809anti-HIV_cap256-038-080981_VR-Chain 2316 9958, 17600, 25242, 32884,40526, 48168, 55810 anti-HIV_cap256-038-080873_VR-Chain 2317 9959,17601, 25243, 32885, 40527, 48169, 55811anti-HIV_cap256-038-074413_VR-Chain 2318 9960, 17602, 25244, 32886,40528, 48170, 55812 anti-HIV_cap256-038-073153_VR-Chain 2319 9961,17603, 25245, 32887, 40529, 48171, 55813anti-HIV_cap256-038-064227_VR-Chain 2320 9962, 17604, 25246, 32888,40530, 48172, 55814 anti-HIV_cap256-038-061640_VR-Chain 2321 9963,17605, 25247, 32889, 40531, 48173, 55815anti-HIV_cap256-038-059482_VR-Chain 2322 9964, 17606, 25248, 32890,40532, 48174, 55816 anti-HIV_cap256-038-054000_VR-Chain 2323 9965,17607, 25249, 32891, 40533, 48175, 55817anti-HIV_cap256-038-050554_VR-Chain 2324 9966, 17608, 25250, 32892,40534, 48176, 55818 anti-HIV_cap256-038-044256_VR-Chain 2325 9967,17609, 25251, 32893, 40535, 48177, 55819anti-HIV_cap256-038-040944_VR-Chain 2326 9968, 17610, 25252, 32894,40536, 48178, 55820 anti-HIV_cap256-038-040090_VR-Chain 2327 9969,17611, 25253, 32895, 40537, 48179, 55821anti-HIV_cap256-038-032874_VR-Chain 2328 9970, 17612, 25254, 32896,40538, 48180, 55822 anti-HIV_cap256-038-025899_VR-Chain 2329 9971,17613, 25255, 32897, 40539, 48181, 55823anti-HIV_cap256-038-024581_VR-Chain 2330 9972, 17614, 25256, 32898,40540, 48182, 55824 anti-HIV_cap256-038-013345_VR-Chain 2331 9973,17615, 25257, 32899, 40541, 48183, 55825anti-HIV_cap256-038-011559_VR-Chain 2332 9974, 17616, 25258, 32900,40542, 48184, 55826 anti-HIV_cap256-038-009634_VR-Chain 2333 9975,17617, 25259, 32901, 40543, 48185, 55827anti-HIV_cap256-038-006730_VR-Chain 2334 9976, 17618, 25260, 32902,40544, 48186, 55828 anti-HIV_cap256-038-004887_VR-Chain 2335 9977,17619, 25261, 32903, 40545, 48187, 55829anti-HIV_cap256-038-004840_VR-Chain 2336 9978, 17620, 25262, 32904,40546, 48188, 55830 anti-HIV_cap256-038-002181_VR-Chain 2337 9979,17621, 25263, 32905, 40547, 48189, 55831anti-HIV_cap256-038-001902_VR-Chain 2338 9980, 17622, 25264, 32906,40548, 48190, 55832 anti-HIV_cap256-038-000976_VR-Chain 2339 9981,17623, 25265, 32907, 40549, 48191, 55833anti-HIV_cap256-038-000384_VR-Chain 2340 9982, 17624, 25266, 32908,40550, 48192, 55834 anti-HIV_206-314431_VR-Chain 2341 9983, 17625,25267, 32909, 40551, 48193, 55835 anti-HIV_206-247594_VR-Chain 23429984, 17626, 25268, 32910, 40552, 48194, 55836anti-HIV_206-116890_VR-Chain 2343 9985, 17627, 25269, 32911, 40553,48195, 55837 anti-HIV_206-072383_VR-Chain 2344 9986, 17628, 25270,32912, 40554, 48196, 55838 anti-HIV_206-037527_VR-Chain 2345 9987,17629, 25271, 32913, 40555, 48197, 55839 anti-HIV_206-009095_VR-Chain2346 9988, 17630, 25272, 32914, 40556, 48198, 55840anti-HIV_176-503620_VR-Chain 2347 9989, 17631, 25273, 32915, 40557,48199, 55841 anti-HIV_176-478729_VR-Chain 2348 9990, 17632, 25274,32916, 40558, 48200, 55842 anti-HIV_176-245059_VR-Chain 2349 9991,17633, 25275, 32917, 40559, 48201, 55843 anti-HIV_176-164413_VR-Chain2350 9992, 17634, 25276, 32918, 40560, 48202, 55844anti-HIV_176-094308_VR-Chain 2351 9993, 17635, 25277, 32919, 40561,48203, 55845 anti-HIV_176-065321_VR-Chain 2352 9994, 17636, 25278,32920, 40562, 48204, 55846 anti-HIV_119-099719_VR-Chain 2353 9995,17637, 25279, 32921, 40563, 48205, 55847 anti-HIV_119-099536_VR-Chain2354 9996, 17638, 25280, 32922, 40564, 48206, 55848anti-HIV_119-098907_VR-Chain 2355 9997, 17639, 25281, 32923, 40565,48207, 55849 anti-HIV_119-098555_VR-Chain 2356 9998, 17640, 25282,32924, 40566, 48208, 55850 anti-HIV_119-097828_VR-Chain 2357 9999,17641, 25283, 32925, 40567, 48209, 55851 anti-HIV_119-096480_VR-Chain2358 10000, 17642, 25284, 32926, 40568, 48210, 55852anti-HIV_119-095664_VR-Chain 2359 10001, 17643, 25285, 32927, 40569,48211, 55853 anti-HIV_119-095212_VR-Chain 2360 10002, 17644, 25286,32928, 40570, 48212, 55854 anti-HIV_119-094773_VR-Chain 2361 10003,17645, 25287, 32929, 40571, 48213, 55855 anti-HIV_119-094508_VR-Chain2362 10004, 17646, 25288, 32930, 40572, 48214, 55856anti-HIV_119-093795_VR-Chain 2363 10005, 17647, 25289, 32931, 40573,48215, 55857 anti-HIV_119-093732_VR-Chain 2364 10006, 17648, 25290,32932, 40574, 48216, 55858 anti-HIV_119-092903_VR-Chain 2365 10007,17649, 25291, 32933, 40575, 48217, 55859 anti-HIV_119-092284_VR-Chain2366 10008, 17650, 25292, 32934, 40579, 48218, 55860anti-HIV_119-091586_VR-Chain 2367 10009, 17651, 25293, 32935, 40577,48219, 55861 anti-HIV_119-091023_VR-Chain 2368 10010, 17652, 25294,32936, 40578, 48220, 55862 anti-HIV_119-090334_VR-Chain 2369 10011,17653, 25295, 32937, 40579, 48221, 55863 anti-HIV_119-088694_VR-Chain2370 10012, 17654, 25296, 32938, 40580, 48222, 55864anti-HIV_119-088499_VR-Chain 2371 10013, 17655, 25297, 32939, 40581,48223, 55865 anti-HIV_119-088298_VR-Chain 2372 10014, 17656, 25298,32940, 40582, 48224, 55866 anti-HIV_119-087488_VR-Chain 2373 10015,17657, 25299, 32941, 40583, 48225, 55867 anti-HIV_119-087423_VR-Chain2374 10016, 17658, 25300, 32942, 40584, 48226, 55868anti-HIV_119-087371_VR-Chain 2375 10017, 17659, 25301, 32943, 40585,48227, 55869 anti-HIV_119-087279_VR-Chain 2376 10018, 17660, 25302,32944, 40586, 48228, 55870 anti-HIV_119-087146_VR-Chain 2377 10019,17661, 25303, 32945, 40587, 48229, 55871 anti-HIV_119-087048_VR-Chain2378 10020, 17662, 25304, 32946, 40588, 48230, 55872anti-HIV_119-085802_VR-Chain 2379 10021, 17663, 25305, 32947, 40589,48231, 55873 anti-HIV_119-085784_VR-Chain 2380 10022, 17664, 25306,32948, 40590, 48232, 55874 anti-HIV_119-085370_VR-Chain 2381 10023,17665, 25307, 32949, 40591, 48233, 55875 anti-HIV_119-085276_VR-Chain2382 10024, 17666, 25308, 32950, 40592, 48234, 55876anti-HIV_119-084885_VR-Chain 2383 10025, 17667, 25309, 32951, 40593,48235, 55877 anti-HIV_119-084874_VR-Chain 2384 10026, 17668, 25310,32952, 40594, 48236, 55878 anti-HIV_119-084691_VR-Chain 2385 10027,17669, 25311, 32953, 40595, 48237, 55879 anti-HIV_119-083793_VR-Chain2386 10028, 17670, 25312, 32954, 40596, 48238, 55880anti-HIV_119-083163_VR-Chain 2387 10029, 17671, 25313, 32955, 40597,48239, 55881 anti-HIV_119-082331_VR-Chain 2388 10030, 17672, 25314,32956, 40598, 48240, 55882 anti-HIV_119-082070_VR-Chain 2389 10031,17673, 25315, 32957, 40599, 48241, 55883 anti-HIV_119-081512_VR-Chain2390 10032, 17674, 25316, 32958, 40600, 48242, 55884anti-HIV_119-080816_VR-Chain 2391 10033, 17675, 25317, 32959, 40601,48243, 55885 anti-HIV_119-079302_VR-Chain 2392 10034, 17676, 25318,32960, 40602, 48244, 55886 anti-HIV_119-079292_VR-Chain 2393 10035,17677, 25319, 32961, 40603, 48245, 55887 anti-HIV_119-079289_VR-Chain2394 10036, 17678, 25320, 32962, 40604, 48246, 55888anti-HIV_119-078935_VR-Chain 2395 10037, 17679, 25321, 32963, 40605,48247, 55889 anti-HIV_119-078702_VR-Chain 2396 10038, 17680, 25322,32964, 40606, 48248, 55890 anti-HIV_119-078593_VR-Chain 2397 10039,17681, 25323, 32965, 40607, 48249, 55891 anti-HIV_119-077708_VR-Chain2398 10040, 17682, 25324, 32966, 40608, 48250, 55892anti-HIV_119-076904_VR-Chain 2399 10041, 17683, 25325, 32967, 40609,48251, 55893 anti-HIV_119-075862_VR-Chain 2400 10042, 17684, 25326,32968, 40610, 48252, 55894 anti-HIV_119-075465_VR-Chain 2401 10043,17685, 25327, 32969, 40611, 48253, 55895 anti-HIV_119-074822_VR-Chain2402 10044, 17686, 25328, 32970, 40612, 48254, 55896anti-HIV_119-074629_VR-Chain 2403 10045, 17687, 25329, 32971, 40613,48255, 55897 anti-HIV_119-074500_VR-Chain 2404 10046, 17688, 25330,32972, 40614, 48256, 55898 anti-HIV_119-073911_VR-Chain 2405 10047,17689, 25331, 32973, 40615, 48257, 55899 anti-HIV_119-072765_VR-Chain2406 10048, 17690, 25332, 32974, 40616, 48258, 55900anti-HIV_119-072313_VR-Chain 2407 10049, 17691, 25333, 32975, 40617,48259, 55901 anti-HIV_119-072280_VR-Chain 2408 10050, 17692, 25334,32976, 40618, 48260, 55902 anti-HIV_119-071693_VR-Chain 2409 10051,17693, 25335, 32977, 40619, 48261, 55903 anti-HIV_119-071353_VR-Chain2410 10052, 17694, 25336, 32978, 40620, 48262, 55904anti-HIV_119-069711_VR-Chain 2411 10053, 17695, 25337, 32979, 40621,48263, 55905 anti-HIV_119-069061_VR-Chain 2412 10054, 17696, 25338,32980, 40622, 48264, 55906 anti-HIV_119-068202_VR-Chain 2413 10055,17697, 25339, 32981, 40623, 48265, 55907 anti-HIV_119-068063_VR-Chain2414 10056, 17698, 25340, 32982, 40624, 48266, 55908anti-HIV_119-067980_VR-Chain 2415 10057, 17699, 25341, 32983, 40625,48267, 55909 anti-HIV_119-067866_VR-Chain 2416 10058, 17700, 25342,32984, 40626, 48268, 55910 anti-HIV_119-067756_VR-Chain 2417 10059,17701, 25343, 32985, 40627, 48269, 55911 anti-HIV_119-066859_VR-Chain2418 10060, 17702, 25344, 32986, 40628, 48270, 55912anti-HIV_119-065821_VR-Chain 2419 10061, 17703, 25345, 32987, 40629,48271, 55913 anti-HIV_119-065191_VR-Chain 2420 10062, 17704, 25346,32988, 40630, 48272, 55914 anti-HIV_119-064667_VR-Chain 2421 10063,17705, 25347, 32989, 40631, 48273, 55915 anti-HIV_119-063791_VR-Chain2422 10064, 17706, 25348, 32990, 40632, 48274, 55916anti-HIV_119-062989_VR-Chain 2423 10065, 17707, 25349, 32991, 40633,48275, 55917 anti-HIV_119-062286_VR-Chain 2424 10066, 17708, 25350,32992, 40634, 48276, 55918 anti-HIV_119-061416_VR-Chain 2425 10067,17709, 25351, 32993, 40635, 48277, 55919 anti-HIV_119-061344_VR-Chain2426 10068, 17710, 25352, 32994, 40636, 48278, 55920anti-HIV_119-060240_VR-Chain 2427 10069, 17711, 25353, 32995, 40637,48279, 55921 anti-HIV_119-060184_VR-Chain 2428 10070, 17712, 25354,32996, 40638, 48280, 55922 anti-HIV_119-058035_VR-Chain 2429 10071,17713, 25355, 32997, 40639, 48281, 55923 anti-HIV_119-057858_VR-Chain2430 10072, 17714, 25356, 32998, 40640, 48282, 55924anti-HIV_119-057473_VR-Chain 2431 10073, 17715, 25357, 32999, 40641,48283, 55925 anti-HIV_119-057090_VR-Chain 2432 10074, 17716, 25358,33000, 40642, 48284, 55926 anti-HIV_119-055754_VR-Chain 2433 10075,17717, 25359, 33001, 40643, 48285, 55927 anti-HIV_119-054899_VR-Chain2434 10076, 17718, 25360, 33002, 40644, 48286, 55928anti-HIV_119-054501_VR-Chain 2435 10077, 17719, 25361, 33003, 40645,48287, 55929 anti-HIV_119-051867_VR-Chain 2436 10078, 17720, 25362,33004, 40646, 48288, 55930 anti-HIV_119-051814_VR-Chain 2437 10079,17721, 25363, 33005, 40647, 48289, 55931 anti-HIV_119-051567_VR-Chain2438 10080, 17722, 25364, 33006, 40648, 48290, 55932anti-HIV_119-051483_VR-Chain 2439 10081, 17723, 25365, 33007, 40649,48291, 55933 anti-HIV_119-050913_VR-Chain 2440 10082, 17724, 25366,33008, 40650, 48292, 55934 anti-HIV_119-050187_VR-Chain 2441 10083,17725, 25367, 33009, 40651, 48293, 55935 anti-HIV_119-049069_VR-Chain2442 10084, 17726, 25368, 33010, 40652, 48294, 55936anti-HIV_119-048517_VR-Chain 2443 10085, 17727, 25369, 33011, 40653,48295, 55937 anti-HIV_119-048470_VR-Chain 2444 10086, 17728, 25370,33012, 40654, 48296, 55938 anti-HIV_119-048303_VR-Chain 2445 10087,17729, 25371, 33013, 40655, 48297, 55939 anti-HIV_119-048021_VR-Chain2446 10088, 17730, 25372, 33014, 40656, 48298, 55940anti-HIV_119-047928_VR-Chain 2447 10089, 17731, 25373, 33015, 40657,48299, 55941 anti-HIV_119-047384_VR-Chain 2448 10090, 17732, 25374,33016, 40658, 48300, 55942 anti-HIV_119-047145_VR-Chain 2449 10091,17733, 25375, 33017, 40659, 48301, 55943 anti-HIV_119-046752_VR-Chain2450 10092, 17734, 25376, 33018, 40660, 48302, 55944anti-HIV_119-046660_VR-Chain 2451 10093, 17735, 25377, 33019, 40661,48303, 55945 anti-HIV_119-046202_VR-Chain 2452 10094, 17736, 25378,33020, 40662, 48304, 55946 anti-HIV_119-045790_VR-Chain 2453 10095,17737, 25379, 33021, 40663, 48305, 55947 anti-HIV_119-044670_VR-Chain2454 10096, 17738, 25380, 33022, 40664, 48306, 55948anti-HIV_119-044140_VR-Chain 2455 10097, 17739, 25381, 33023, 40665,48307, 55949 anti-HIV_119-042776_VR-Chain 2456 10098, 17740, 25382,33024, 40666, 48308, 55950 anti-HIV_119-042581_VR-Chain 2457 10099,17741, 25383, 33025, 40667, 48309, 55951 anti-HIV_119-040905_VR-Chain2458 10100, 17742, 25384, 33026, 40668, 48310, 55952anti-HIV_119-040322_VR-Chain 2459 10101, 17743, 25385, 33027, 40669,48311, 55953 anti-HIV_119-039892_VR-Chain 2460 10102, 17744, 25386,33028, 40670, 48312, 55954 anti-HIV_119-039764_VR-Chain 2461 10103,17745, 25387, 33029, 40671, 48313, 55955 anti-HIV_119-039188_VR-Chain2462 10104, 17746, 25388, 33030, 40672, 48314, 55956anti-HIV_119-039058_VR-Chain 2463 10105, 17747, 25389, 33031, 40673,48315, 55957 anti-HIV_119-038837_VR-Chain 2464 10106, 17748, 25390,33032, 40674, 48316, 55958 anti-HIV_119-038396_VR-Chain 2465 10107,17749, 25391, 33033, 40675, 48317, 55959 anti-HIV_119-036918_VR-Chain2466 10108, 17750, 25392, 33034, 40676, 48318, 55960anti-HIV_119-036592_VR-Chain 2467 10109, 17751, 25393, 33035, 40677,48319, 55961 anti-HIV_119-036310_VR-Chain 2468 10110, 17752, 25394,33036, 40678, 48320, 55962 anti-HIV_119-035618_VR-Chain 2469 10111,17753, 25395, 33037, 40679, 48321, 55963 anti-HIV_119-035569_VR-Chain2470 10112, 17754, 25396, 33038, 40680, 48322, 55964anti-HIV_119-035466_VR-Chain 2471 10113, 17755, 25397, 33039, 40681,48323, 55965 anti-HIV_119-035157_VR-Chain 2472 10114, 17756, 25398,33040, 40682, 48324, 55966 anti-HIV_119-035121_VR-Chain 2473 10115,17757, 25399, 33041, 40683, 48325, 55967 anti-HIV_119-035046_VR-Chain2474 10116, 17758, 25400, 33042, 40684, 48326, 55968anti-HIV_119-034754_VR-Chain 2475 10117, 17759, 25401, 33043, 40685,48327, 55969 anti-HIV_119-034318_VR-Chain 2476 10118, 17760, 25402,33044, 40686, 48328, 55970 anti-HIV_119-033780_VR-Chain 2477 10119,17761, 25403, 33045, 40687, 48329, 55971 anti-HIV_119-033632_VR-Chain2478 10120, 17762, 25404, 33046, 40688, 48330, 55972anti-HIV_119-033183_VR-Chain 2479 10121, 17763, 25405, 33047, 40689,48331, 55973 anti-HIV_119-030696_VR-Chain 2480 10122, 17764, 25406,33048, 40690, 48332, 55974 anti-HIV_119-030059_VR-Chain 2481 10123,17765, 25407, 33049, 40691, 48333, 55975 anti-HIV_119-029589_VR-Chain2482 10124, 17766, 25408, 33050, 40692, 48334, 55976anti-HIV_119-029448_VR-Chain 2483 10125, 17767, 25409, 33051, 40693,48335, 55977 anti-HIV_119-029220_VR-Chain 2484 10126, 17768, 25410,33052, 40694, 48336, 55978 anti-HIV_119-028317_VR-Chain 2485 10127,17769, 25411, 33053, 40695, 48337, 55979 anti-HIV_119-028165_VR-Chain2486 10128, 17770, 25412, 33054, 40696, 48338, 55980anti-HIV_119-027147_VR-Chain 2487 10129, 17771, 25413, 33055, 40697,48339, 55981 anti-HIV_119-026743_VR-Chain 2488 10130, 17772, 25414,33056, 40698, 48340, 55982 anti-HIV_119-026508_VR-Chain 2489 10131,17773, 25415, 33057, 40699, 48341, 55983 anti-HIV_119-025683_VR-Chain2490 10132, 17774, 25416, 33058, 40700, 48342, 55984anti-HIV_119-025614_VR-Chain 2491 10133, 17775, 25417, 33059, 40701,48343, 55985 anti-HIV_119-025548_VR-Chain 2492 10134, 17776, 25418,33060, 40702, 48344, 55986 anti-HIV_119-025526_VR-Chain 2493 10135,17777, 25419, 33061, 40703, 48345, 55987 anti-HIV_119-023552_VR-Chain2494 10136, 17778, 25420, 33062, 40704, 48346, 55988anti-HIV_119-023092_VR-Chain 2495 10137, 17779, 25421, 33063, 40705,48347, 55989 anti-HIV_119-022793_VR-Chain 2496 10138, 17780, 25422,33064, 40706, 48348, 55990 anti-HIV_119-022395_VR-Chain 2497 10139,17781, 25423, 33065, 40707, 48349, 55991 anti-HIV_119-022334_VR-Chain2498 10140, 17782, 25424, 33066, 40708, 48350, 55992anti-HIV_119-021866_VR-Chain 2499 10141, 17783, 25425, 33067, 40709,48351, 55993 anti-HIV_119-021278_VR-Chain 2500 10142, 17784, 25426,33068, 40710, 48352, 55994 anti-HIV_119-021183_VR-Chain 2501 10143,17785, 25427, 33069, 40711, 48353, 55995 anti-HIV_119-019376_VR-Chain2502 10144, 17786, 25428, 33070, 40712, 48354, 55996anti-HIV_119-019238_VR-Chain 2503 10145, 17787, 25429, 33071, 40713,48355, 55997 anti-HIV_119-018500_VR-Chain 2504 10146, 17788, 25430,33072, 40714, 48356, 55998 anti-HIV_119-018318_VR-Chain 2505 10147,17789, 25431, 33073, 40715, 48357, 55999 anti-HIV_119-018218_VR-Chain2506 10148, 17790, 25432, 33074, 40716, 48358, 56000anti-HIV_119-017876_VR-Chain 2507 10149, 17791, 25433, 33075, 40717,48359, 56001 anti-HIV_119-017740_VR-Chain 2508 10150, 17792, 25434,33076, 40718, 48360, 56002 anti-HIV_119-017128_VR-Chain 2509 10151,17793, 25435, 33077, 40719, 48361, 56003 anti-HIV_119-017044_VR-Chain2510 10152, 17794, 25436, 33078, 40720, 48362, 56004anti-HIV_119-016644_VR-Chain 2511 10153, 17795, 25437, 33079, 40721,48363, 56005 anti-HIV_119-015878_VR-Chain 2512 10154, 17796, 25438,33080, 40722, 48364, 56006 anti-HIV_119-015538_VR-Chain 2513 10155,17797, 25439, 33081, 40723, 48365, 56007 anti-HIV_119-015455_VR-Chain2514 10156, 17798, 25440, 33082, 40724, 48366, 56008anti-HIV_119-014425_VR-Chain 2515 10157, 17799, 25441, 33083, 40725,48367, 56009 anti-HIV_119-013582_VR-Chain 2516 10158, 17800, 25442,33084, 40726, 48368, 56010 anti-HIV_119-013364_VR-Chain 2517 10159,17801, 25443, 33085, 40727, 48369, 56011 anti-HIV_119-012886_VR-Chain2518 10160, 17802, 25444, 33086, 40728, 48370, 56012anti-HIV_119-012249_VR-Chain 2519 10161, 17803, 25445, 33087, 40729,48371, 56013 anti-HIV_119-012161_VR-Chain 2520 10162, 17804, 25446,33088, 40730, 48372, 56014 anti-HIV_119-012110_VR-Chain 2521 10163,17805, 25447, 33089, 40731, 48373, 56015 anti-HIV_119-012100_VR-Chain2522 10164, 17806, 25448, 33090, 40732, 48374, 56016anti-HIV_119-011651_VR-Chain 2523 10165, 17807, 25449, 33091, 40733,48375, 56017 anti-HIV_119-011479_VR-Chain 2524 10166, 17808, 25450,33092, 40734, 48376, 56018 anti-HIV_119-011232_VR-Chain 2525 10167,17809, 25451, 33093, 40735, 48377, 56019 anti-HIV_119-011175_VR-Chain2526 10168, 17810, 25452, 33094, 40736, 48378, 56020anti-HIV_119-008396_VR-Chain 2527 10169, 17811, 25453, 33095, 40737,48379, 56021 anti-HIV_119-007148_VR-Chain 2528 10170, 17812, 25454,33096, 40738, 48380, 56022 anti-HIV_119-007029_VR-Chain 2529 10171,17813, 25455, 33097, 40739, 48381, 56023 anti-HIV_119-004707_VR-Chain2530 10172, 17814, 25456, 33098, 40740, 48382, 56024anti-HIV_119-003910_VR-Chain 2531 10173, 17815, 25457, 33099, 40741,48383, 56025 anti-HIV_119-002450_VR-Chain 2532 10174, 17816, 25458,33100, 40742, 48384, 56026 anti-HIV_119-001552_VR-Chain 2533 10175,17817, 25459, 33101, 40743, 48385, 56027 anti-HIV_059-188169_VR-Chain2534 10176, 17818, 25460, 33102, 40744, 48386, 56028anti-HIV_059-183739_VR-Chain 2535 10177, 17819, 25461, 33103, 40745,48387, 56029 anti-HIV_059-182376_VR-Chain 2536 10178, 17820, 25462,33104, 40746, 48388, 56030 anti-HIV_059-182199_VR-Chain 2537 10179,17821, 25463, 33105, 40747, 48389, 56031 anti-HIV_059-169202_VR-Chain2538 10180, 17822, 25464, 33106, 40748, 48390, 56032anti-HIV_059-155645_VR-Chain 2539 10181, 17823, 25465, 33107, 40749,48391, 56033 anti-HIV_059-151619_VR-Chain 2540 10182, 17824, 25466,33108, 40750, 48392, 56034 anti-HIV_059-146503_VR-Chain 2541 10183,17825, 25467, 33109, 40751, 48393, 56035 anti-HIV_059-136098_VR-Chain2542 10184, 17826, 25468, 33110, 40752, 48394, 56036anti-HIV_059-105516_VR-Chain 2543 10185, 17827, 25469, 33111, 40753,48395, 56037 anti-HIV_059-095709_VR-Chain 2544 10186, 17828, 25470,33112, 40754, 48396, 56038 anti-HIV_059-069468_VR-Chain 2545 10187,17829, 25471, 33113, 40755, 48397, 56039 anti-HIV_059-060026_VR-Chain2546 10188, 17830, 25472, 33114, 40756, 48398, 56040anti-HIV_059-053668_VR-Chain 2547 10189, 17831, 25473, 33115, 40757,48399, 56041 anti-HIV_059-052864_VR-Chain 2548 10190, 17832, 25474,33116, 40758, 48400, 56042 anti-HIV_059-050968_VR-Chain 2549 10191,17833, 25475, 33117, 40759, 48401, 56043 anti-HIV_059-046422_VR-Chain2550 10192, 17834, 25476, 33118, 40760, 48402, 56044anti-HIV_059-045120_VR-Chain 2551 10193, 17835, 25477, 33119, 40761,48403, 56045 anti-HIV_059-039932_VR-Chain 2552 10194, 17836, 25478,33120, 40762, 48404, 56046 anti-HIV_059-038595_VR-Chain 2553 10195,17837, 25479, 33121, 40763, 48405, 56047 anti-HIV_059-035082_VR-Chain2554 10196, 17838, 25480, 33122, 40764, 48406, 56048anti-HIV_059-029204_VR-Chain 2555 10197, 17839, 25481, 33123, 40765,48407, 56049 anti-HIV_059-025235_VR-Chain 2556 10198, 17840, 25482,33124, 40766, 48408, 56050 anti-HIV_059-015192_VR-Chain 2557 10199,17841, 25483, 33125, 40767, 48409, 56051 anti-HIV_059-007060_VR-Chain2558 10200, 17842, 25484, 33126, 40768, 48410, 56052anti-HIV_059-006953_VR-Chain 2559 10201, 17843, 25485, 33127, 40769,48411, 56053 anti-HIV_059-005953_VR-Chain 2560 10202, 17844, 25486,33128, 40770, 48412, 56054 anti-HIV_059-003725_VR-Chain 2561 10203,17845, 25487, 33129, 40771, 48413, 56055 anti-HIV_059-002618_VR-Chain2562 10204, 17846, 25488, 33130, 40772, 48414, 56056anti-HIV_059-001522_VR-Chain 2563 10205, 17847, 25489, 33131, 40773,48415, 56057 anti-HIV_059-000731_VR-Chain 2564 10206, 17848, 25490,33132, 40774, 48416, 56058 anti-HIV_059-000634_VR-Chain 2565 10207,17849, 25491, 33133, 40775, 48417, 56059 anti-HIV_048-250757_VR-Chain2566 10208, 17850, 25492, 33134, 40776, 48418, 56060anti-HIV_048-250716_VR-Chain 2567 10209, 17851, 25493, 33135, 40777,48419, 56061 anti-HIV_048-250463_VR-Chain 2568 10210, 17852, 25494,33136, 40778, 48420, 56062 anti-HIV_048-248153_VR-Chain 2569 10211,17853, 25495, 33137, 40779, 48421, 56063 anti-HIV_048-247532_VR-Chain2570 10212, 17854, 25496, 33138, 40780, 48422, 56064anti-HIV_048-245846_VR-Chain 2571 10213, 17855, 25497, 33139, 40781,48423, 56065 anti-HIV_048-244016_VR-Chain 2572 10214, 17856, 25498,33140, 40782, 48424, 56066 anti-HIV_048-243682_VR-Chain 2573 10215,17857, 25499, 33141, 40783, 48425, 56067 anti-HIV_048-243588_VR-Chain2574 10216, 17858, 25500, 33142, 40784, 48426, 56068anti-HIV_048-241775_VR-Chain 2575 10217, 17859, 25501, 33143, 40785,48427, 56069 anti-HIV_048-237996_VR-Chain 2576 10218, 17860, 25502,33144, 40786, 48428, 56070 anti-HIV_048-237730_VR-Chain 2577 10219,17861, 25503, 33145, 40787, 48429, 56071 anti-HIV_048-237253_VR-Chain2578 10220, 17862, 25504, 33146, 40788, 48430, 56072anti-HIV_048-234100_VR-Chain 2579 10221, 17863, 25505, 33147, 40789,48431, 56073 anti-HIV_048-230882_VR-Chain 2580 10222, 17864, 25506,33148, 40790, 48432, 56074 anti-HIV_048-229473_VR-Chain 2581 10223,17865, 25507, 33149, 40791, 48433, 56075 anti-HIV_048-228238_VR-Chain2582 10224, 17869, 25508, 33150, 40792, 48434, 56079anti-HIV_048-228027_VR-Chain 2583 10225, 17867, 25509, 33151, 40793,48435, 56077 anti-HIV_048-227795_VR-Chain 2584 10226, 17868, 25510,33152, 40794, 48436, 56078 anti-HIV_048-227770_VR-Chain 2585 10227,17869, 25511, 33153, 40795, 48437, 56079 anti-HIV_048-225298_VR-Chain2586 10228, 17870, 25512, 33154, 40796, 48438, 56080anti-HIV_048-225090_VR-Chain 2587 10229, 17871, 25513, 33155, 40797,48439, 56081 anti-HIV_048-224187_VR-Chain 2588 10230, 17872, 25514,33156, 40798, 48440, 56082 anti-HIV_048-223055_VR-Chain 2589 10231,17873, 25515, 33157, 40799, 48441, 56083 anti-HIV_048-222711_VR-Chain2590 10232, 17874, 25516, 33158, 40800, 48442, 56084anti-HIV_048-221209_VR-Chain 2591 10233, 17875, 25517, 33159, 40801,48443, 56085 anti-HIV_048-220929_VR-Chain 2592 10234, 17876, 25518,33160, 40802, 48444, 56086 anti-HIV_048-219430_VR-Chain 2593 10235,17877, 25519, 33161, 40803, 48445, 56087 anti-HIV_048-216250_VR-Chain2594 10236, 17878, 25520, 33162, 40804, 48446, 56088anti-HIV_048-216133_VR-Chain 2595 10237, 17879, 25521, 33163, 40805,48447, 56089 anti-HIV_048-214886_VR-Chain 2596 10238, 17880, 25522,33164, 40806, 48448, 56090 anti-HIV_048-214709_VR-Chain 2597 10239,17881, 25523, 33165, 40807, 48449, 56091 anti-HIV_048-214001_VR-Chain2598 10240, 17882, 25524, 33166, 40808, 48450, 56092anti-HIV_048-213230_VR-Chain 2599 10241, 17883, 25525, 33167, 40809,48451, 56093 anti-HIV_048-212574_VR-Chain 2600 10242, 17884, 25526,33168, 40810, 48452, 56094 anti-HIV_048-212207_VR-Chain 2601 10243,17885, 25527, 33169, 40811, 48453, 56095 anti-HIV_048-209146_VR-Chain2602 10244, 17886, 25528, 33170, 40812, 48454, 56096anti-HIV_048-208206_VR-Chain 2603 10245, 17887, 25529, 33171, 40813,48455, 56097 anti-HIV_048-208194_VR-Chain 2604 10246, 17888, 25530,33172, 40814, 48456, 56098 anti-HIV_048-207744_VR-Chain 2605 10247,17889, 25531, 33173, 40815, 48457, 56099 anti-HIV_048-206501_VR-Chain2606 10248, 17890, 25532, 33174, 40816, 48458, 56100anti-HIV_048-204221_VR-Chain 2607 10249, 17891, 25533, 33175, 40817,48459, 56101 anti-HIV_048-204015_VR-Chain 2608 10250, 17892, 25534,33176, 40818, 48460, 56102 anti-HIV_048-201240_VR-Chain 2609 10251,17893, 25535, 33177, 40819, 48461, 56103 anti-HIV_048-200455_VR-Chain2610 10252, 17894, 25536, 33178, 40820, 48462, 56104anti-HIV_048-200319_VR-Chain 2611 10253, 17895, 25537, 33179, 40821,48463, 56105 anti-HIV_048-197896_VR-Chain 2612 10254, 17896, 25538,33180, 40822, 48464, 56106 anti-HIV_048-193813_VR-Chain 2613 10255,17897, 25539, 33181, 40823, 48465, 56107 anti-HIV_048-192098_VR-Chain2614 10256, 17898, 25540, 33182, 40824, 48466, 56108anti-HIV_048-191786_VR-Chain 2615 10257, 17899, 25541, 33183, 40825,48467, 56109 anti-HIV_048-188746_VR-Chain 2616 10258, 17900, 25542,33184, 40826, 48468, 56110 anti-HIV_048-185937_VR-Chain 2617 10259,17901, 25543, 33185, 40827, 48469, 56111 anti-HIV_048-184849_VR-Chain2618 10260, 17902, 25544, 33186, 40828, 48470, 56112anti-HIV_048-183089_VR-Chain 2619 10261, 17903, 25545, 33187, 40829,48471, 56113 anti-HIV_048-181509_VR-Chain 2620 10262, 17904, 25546,33188, 40830, 48472, 56114 anti-HIV_048-180990_VR-Chain 2621 10263,17905, 25547, 33189, 40831, 48473, 56115 anti-HIV_048-177532_VR-Chain2622 10264, 17906, 25548, 33190, 40832, 48474, 56116anti-HIV_048-177426_VR-Chain 2623 10265, 17907, 25549, 33191, 40833,48475, 56117 anti-HIV_048-177389_VR-Chain 2624 10266, 17908, 25550,33192, 40834, 48476, 56118 anti-HIV_048-174266_VR-Chain 2625 10267,17909, 25551, 33193, 40835, 48477, 56119 anti-HIV_048-172847_VR-Chain2626 10268, 17910, 25552, 33194, 40836, 48478, 56120anti-HIV_048-172845_VR-Chain 2627 10269, 17911, 25553, 33195, 40837,48479, 56121 anti-HIV_048-172363_VR-Chain 2628 10270, 17912, 25554,33196, 40838, 48480, 56122 anti-HIV_048-171609_VR-Chain 2629 10271,17913, 25555, 33197, 40839, 48481, 56123 anti-HIV_048-170705_VR-Chain2630 10272, 17914, 25556, 33198, 40840, 48482, 56124anti-HIV_048-168381_VR-Chain 2631 10273, 17915, 25557, 33199, 40841,48483, 56125 anti-HIV_048-166619_VR-Chain 2632 10274, 17916, 25558,33200, 40842, 48484, 56126 anti-HIV_048-162036_VR-Chain 2633 10275,17917, 25559, 33201, 40843, 48485, 56127 anti-HIV_048-160042_VR-Chain2634 10276, 17918, 25560, 33202, 40844, 48486, 56128anti-HIV_048-159676_VR-Chain 2635 10277, 17919, 25561, 33203, 40845,48487, 56129 anti-HIV_048-159500_VR-Chain 2636 10278, 17920, 25562,33204, 40846, 48488, 56130 anti-HIV_048-159421_VR-Chain 2637 10279,17921, 25563, 33205, 40847, 48489, 56131 anti-HIV_048-159333_VR-Chain2638 10280, 17922, 25564, 33206, 40848, 48490, 56132anti-HIV_048-158932_VR-Chain 2639 10281, 17923, 25565, 33207, 40849,48491, 56133 anti-HIV_048-155811_VR-Chain 2640 10282, 17924, 25566,33208, 40850, 48492, 56134 anti-HIV_048-155464_VR-Chain 2641 10283,17925, 25567, 33209, 40851, 48493, 56135 anti-HIV_048-155392_VR-Chain2642 10284, 17926, 25568, 33210, 40852, 48494, 56136anti-HIV_048-155389_VR-Chain 2643 10285, 17927, 25569, 33211, 40853,48495, 56137 anti-HIV_048-154449_VR-Chain 2644 10286, 17928, 25570,33212, 40854, 48496, 56138 anti-HIV_048-153379_VR-Chain 2645 10287,17929, 25571, 33213, 40855, 48497, 56139 anti-HIV_048-153171_VR-Chain2646 10288, 17930, 25572, 33214, 40856, 48498, 56140anti-HIV_048-152324_VR-Chain 2647 10289, 17931, 25573, 33215, 40857,48499, 56141 anti-HIV_048-146102_VR-Chain 2648 10290, 17932, 25574,33216, 40858, 48500, 56142 anti-HIV_048-145984_VR-Chain 2649 10291,17933, 25575, 33217, 40859, 48501, 56143 anti-HIV_048-145371_VR-Chain2650 10292, 17934, 25576, 33218, 40860, 48502, 56144anti-HIV_048-144907_VR-Chain 2651 10293, 17935, 25577, 33219, 40861,48503, 56145 anti-HIV_048-142298_VR-Chain 2652 10294, 17936, 25578,33220, 40862, 48504, 56146 anti-HIV_048-142277_VR-Chain 2653 10295,17937, 25579, 33221, 40863, 48505, 56147 anti-HIV_048-141934_VR-Chain2654 10296, 17938, 25580, 33222, 40864, 48506, 56148anti-HIV_048-141207_VR-Chain 2655 10297, 17939, 25581, 33223, 40865,48507, 56149 anti-HIV_048-140796_VR-Chain 2656 10298, 17940, 25582,33224, 40866, 48508, 56150 anti-HIV_048-139893_VR-Chain 2657 10299,17941, 25583, 33225, 40867, 48509, 56151 anti-HIV_048-138820_VR-Chain2658 10300, 17942, 25584, 33226, 40868, 48510, 56152anti-HIV_048-135858_VR-Chain 2659 10301, 17943, 25585, 33227, 40869,48511, 56153 anti-HIV_048-134968_VR-Chain 2660 10302, 17944, 25586,33228, 40870, 48512, 56154 anti-HIV_048-134312_VR-Chain 2661 10303,17945, 25587, 33229, 40871, 48513, 56155 anti-HIV_048-132253_VR-Chain2662 10304, 17946, 25588, 33230, 40872, 48514, 56156anti-HIV_048-130710_VR-Chain 2663 10305, 17947, 25589, 33231, 40873,48515, 56157 anti-HIV_048-128564_VR-Chain 2664 10306, 17948, 25590,33232, 40874, 48516, 56158 anti-HIV_048-126702_VR-Chain 2665 10307,17949, 25591, 33233, 40875, 48517, 56159 anti-HIV_048-124521_VR-Chain2666 10308, 17950, 25592, 33234, 40876, 48518, 56160anti-HIV_048-122740_VR-Chain 2667 10309, 17951, 25593, 33235, 40877,48519, 56161 anti-HIV_048-119536_VR-Chain 2668 10310, 17952, 25594,33236, 40878, 48520, 56162 anti-HIV_048-116929_VR-Chain 2669 10311,17953, 25595, 33237, 40879, 48521, 56163 anti-HIV_048-116577_VR-Chain2670 10312, 17954, 25596, 33238, 40880, 48522, 56164anti-HIV_048-116045_VR-Chain 2671 10313, 17955, 25597, 33239, 40881,48523, 56165 anti-HIV_048-115875_VR-Chain 2672 10314, 17956, 25598,33240, 40882, 48524, 56166 anti-HIV_048-115599_VR-Chain 2673 10315,17957, 25599, 33241, 40883, 48525, 56167 anti-HIV_048-113988_VR-Chain2674 10316, 17958, 25600, 33242, 40884, 48526, 56168anti-HIV_048-112989_VR-Chain 2675 10317, 17959, 25601, 33243, 40885,48527, 56169 anti-HIV_048-112435_VR-Chain 2676 10318, 17960, 25602,33244, 40886, 48528, 56170 anti-HIV_048-111339_VR-Chain 2677 10319,17961, 25603, 33245, 40887, 48529, 56171 anti-HIV_048-111055_VR-Chain2678 10320, 17962, 25604, 33246, 40888, 48530, 56172anti-HIV_048-111027_VR-Chain 2679 10321, 17963, 25605, 33247, 40889,48531, 56173 anti-HIV_048-109721_VR-Chain 2080 10322, 17964, 25606,33248, 40890, 48532, 56174 anti-HIV_048-109666_VR-Chain 2681 10323,17965, 25607, 33249, 40891, 48533, 56175 anti-HIV_048-109196_VR-Chain2682 10324, 17966, 25608, 33250, 40892, 48534, 56176anti-HIV_048-109051_VR-Chain 2683 10325, 17967, 25609, 33251, 40893,48535, 56177 anti-HIV_048-108570_VR-Chain 2684 10326, 17968, 25610,33252, 40894, 48536, 56178 anti-HIV_048-108033_VR-Chain 2685 10327,17969, 25611, 33253, 40895, 48537, 56179 anti-HIV_048-107279_VR-Chain2686 10328, 17970, 25612, 33254, 40896, 48538, 56180anti-HIV_048-106271_VR-Chain 2687 10329, 17971, 25613, 33255, 40897,48539, 56181 anti-HIV_048-106054_VR-Chain 2688 10330, 17972, 25614,33256, 40898, 48540, 56182 anti-HIV_048-104848_VR-Chain 2689 10331,17973, 25615, 33257, 40899, 48541, 56183 anti-HIV_048-104638_VR-Chain2690 10332, 17974, 25616, 33258, 40900, 48542, 56184anti-HIV_048-104567_VR-Chain 2691 10333, 17975, 25617, 33259, 40901,48543, 56185 anti-HIV_048-102804_VR-Chain 2692 10334, 17976, 25618,33260, 40902, 48544, 56186 anti-HIV_048-101676_VR-Chain 2693 10335,17977, 25619, 33261, 40903, 48545, 56187 anti-HIV_048-097603_VR-Chain2694 10336, 17978, 25620, 33262, 40904, 48546, 56188anti-HIV_048-097107_VR-Chain 2695 10337, 17979, 25621, 33263, 40905,48547, 56189 anti-HIV_048-096871_VR-Chain 2696 10338, 17980, 25622,33264, 40906, 48548, 56190 anti-HIV_048-096668_VR-Chain 2697 10339,17981, 25623, 33265, 40907, 48549, 56191 anti-HIV_048-095236_VR-Chain2698 10340, 17982, 25624, 33266, 40908, 48550, 56192anti-HIV_048-094155_VR-Chain 2699 10341, 17983, 25625, 33267, 40909,48551, 56193 anti-HIV_048-093219_VR-Chain 2700 10342, 17984, 25626,33268, 40910, 48552, 56194 anti-HIV_048-092976_VR-Chain 2701 10343,17985, 25627, 33269, 40911, 48553, 56195 anti-HIV_048-090866_VR-Chain2702 10344, 17986, 25628, 33270, 40912, 48554, 56196anti-HIV_048-090650_VR-Chain 2703 10345, 17987, 25629, 33271, 40913,48555, 56197 anti-HIV_048-089009_VR-Chain 2704 10346, 17988, 25630,33272, 40914, 48556, 56198 anti-HIV_048-088654_VR-Chain 2705 10347,17989, 25631, 33273, 40915, 48557, 56199 anti-HIV_048-086513_VR-Chain2706 10348, 17990, 25632, 33274, 40916, 48558, 56200anti-HIV_048-086024_VR-Chain 2707 10349, 17991, 25633, 33275, 40917,48559, 56201 anti-HIV_048-085857_VR-Chain 2708 10350, 17992, 25634,33276, 40918, 48560, 56202 anti-HIV_048-084277_VR-Chain 2709 10351,17993, 25635, 33277, 40919, 48561, 56203 anti-HIV_048-084245_VR-Chain2710 10352, 17994, 25636, 33278, 40920, 48562, 56204anti-HIV_048-082487_VR-Chain 2711 10353, 17995, 25637, 33279, 40921,48563, 56205 anti-HIV_048-081787_VR-Chain 2712 10354, 17996, 25638,33280, 40922, 48564, 56206 anti-HIV_048-081062_VR-Chain 2713 10355,17997, 25639, 33281, 40923, 48565, 56207 anti-HIV_048-079639_VR-Chain2714 10356, 17998, 25640, 33282, 40924, 48566, 56208anti-HIV_048-079126_VR-Chain 2715 10357, 17999, 25641, 33283, 40925,48567, 56209 anti-HIV_048-073118_VR-Chain 2716 10358, 18000, 25642,33284, 40926, 48568, 56210 anti-HIV_048-070264_VR-Chain 2717 10359,18001, 25643, 33285, 40927, 48569, 56211 anti-HIV_048-069426_VR-Chain2718 10360, 18002, 25644, 33286, 40928, 48570, 56212anti-HIV_048-068564_VR-Chain 2719 10361, 18003, 25645, 33287, 40929,48571, 56213 anti-HIV_048-068345_VR-Chain 2720 10362, 18004, 25646,33288, 40930, 48572, 56214 anti-HIV_048-067337_VR-Chain 2721 10363,18005, 25647, 33289, 40931, 48573, 56215 anti-HIV_048-067180_VR-Chain2722 10364, 18006, 25648, 33290, 40932, 48574, 56216anti-HIV_048-063017_VR-Chain 2723 10365, 18007, 25649, 33291, 40933,48575, 56217 anti-HIV_048-061885_VR-Chain 2724 10366, 18008, 25650,33292, 40934, 48576, 56218 anti-HIV_048-061671_VR-Chain 2725 10367,18009, 25651, 33293, 40935, 48577, 56219 anti-HIV_048-060700_VR-Chain2726 10368, 18010, 25652, 33294, 40936, 48578, 56220anti-HIV_048-060592_VR-Chain 2727 10369, 18011, 25653, 33295, 40937,48579, 56221 anti-HIV_048-060300_VR-Chain 2728 10370, 18012, 25654,33296, 40938, 48580, 56222 anti-HIV_048-059141_VR-Chain 2729 10371,18013, 25655, 33297, 40939, 48581, 56223 anti-HIV_048-057777_VR-Chain2730 10372, 18014, 25656, 33298, 40940, 48582, 56224anti-HIV_048-056928_VR-Chain 2731 10373, 18015, 25657, 33299, 40941,48583, 56225 anti-HIV_048-056131_VR-Chain 2732 10374, 18016, 25658,33300, 40942, 48584, 56226 anti-HIV_048-055864_VR-Chain 2733 10375,18017, 25659, 33301, 40943, 48585, 56227 anti-HIV_048-055094_VR-Chain2734 10376, 18018, 25660, 33302, 40944, 48586, 56228anti-HIV_048-054343_VR-Chain 2735 10377, 18019, 25661, 33303, 40945,48587, 56229 anti-HIV_048-054193_VR-Chain 2736 10378, 18020, 25662,33304, 40946, 48588, 56230 anti-HIV_048-052521_VR-Chain 2737 10379,18021, 25663, 33305, 40947, 48589, 56231 anti-HIV_048-049037_VR-Chain2738 10380, 18022, 25664, 33306, 40948, 48590, 56232anti-HIV_048-048720_VR-Chain 2739 10381, 18023, 25665, 33307, 40949,48591, 56233 anti-HIV_048-048542_VR-Chain 2740 10382, 18024, 25666,33308, 40950, 48592, 56234 anti-HIV_048-047777_VR-Chain 2741 10383,18025, 25667, 33309, 40951, 48593, 56235 anti-HIV_048-046841_VR-Chain2742 10384, 18026, 25668, 33310, 40952, 48594, 56236anti-HIV_048-046202_VR-Chain 2743 10385, 18027, 25669, 33311, 40953,48595, 56237 anti-HIV_048-046059_VR-Chain 2744 10386, 18028, 25670,33312, 40954, 48596, 56238 anti-HIV_048-043568_VR-Chain 2745 10387,18029, 25671, 33313, 40955, 48597, 56239 anti-HIV_048-042713_VR-Chain2746 10388, 18030, 25672, 33314, 40956, 48598, 56240anti-HIV_048-042440_VR-Chain 2747 10389, 18031, 25673, 33315, 40957,48599, 56241 anti-HIV_048-040511_VR-Chain 2748 10390, 18032, 25674,33316, 40958, 48600, 56242 anti-HIV_048-039195_VR-Chain 2749 10391,18033, 25675, 33317, 40959, 48601, 56243 anti-HIV_048-036935_VR-Chain2750 10392, 18034, 25676, 33318, 40960, 48602, 56244anti-HIV_048-034478_VR-Chain 2751 10393, 18035, 25677, 33319, 40961,48603, 56245 anti-HIV_048-031641_VR-Chain 2752 10394, 18036, 25678,33320, 40962, 48604, 56246 anti-HIV_048-029760_VR-Chain 2753 10395,18037, 25679, 33321, 40963, 48605, 56247 anti-HIV_048-027970_VR-Chain2754 10396, 18038, 25680, 33322, 40964, 48606, 56248anti-HIV_048-027337_VR-Chain 2755 10397, 18039, 25681, 33323, 40965,48607, 56249 anti-HIV_048-027217_VR-Chain 2756 10398, 18040, 25682,33324, 40966, 48608, 56250 anti-HIV_048-026760_VR-Chain 2757 10399,18041, 25683, 33325, 40967, 48609, 56251 anti-HIV_048-024800_VR-Chain2758 10400, 18042, 25684, 33326, 40968, 48610, 56252anti-HIV_048-024313_VR-Chain 2759 10401, 18043, 25685, 33327, 40969,48611, 56253 anti-HIV_048-021748_VR-Chain 2760 10402, 18044, 25686,33328, 40970, 48612, 56254 anti-HIV_048-020991_VR-Chain 2761 10403,18045, 25687, 33329, 40971, 48613, 56255 anti-HIV_048-020340_VR-Chain2762 10404, 18046, 25688, 33330, 40972, 48614, 56256anti-HIV_048-019993_VR-Chain 2763 10405, 18047, 25689, 33331, 40973,48615, 56257 anti-HIV_048-019947_VR-Chain 2764 10406, 18048, 25690,33332, 40974, 48616, 56258 anti-HIV_048-017871_VR-Chain 2765 10407,18049, 25691, 33333, 40975, 48617, 56259 anti-HIV_048-015931_VR-Chain2766 10408, 18050, 25692, 33334, 40976, 48618, 56260anti-HIV_048-015920_VR-Chain 2767 10409, 18051, 25693, 33335, 40977,48619, 56261 anti-HIV_048-013898_VR-Chain 2768 10410, 18052, 25694,33336, 40978, 48620, 56262 anti-HIV_048-013429_VR-Chain 2769 10411,18053, 25695, 33337, 40979, 48621, 56263 anti-HIV_048-012358_VR-Chain2770 10412, 18054, 25696, 33338, 40980, 48622, 56264anti-HIV_048-011158_VR-Chain 2771 10413, 18055, 25697, 33339, 40981,48623, 56265 anti-HIV_048-010720_VR-Chain 2772 10414, 18056, 25698,33340, 40982, 48624, 56266 anti-HIV_048-009445_VR-Chain 2773 10415,18057, 25699, 33341, 40983, 48625, 56267 anti-HIV_048-006126_VR-Chain2774 10416, 18058, 25700, 33342, 40984, 48626, 56268anti-HIV_048-005652_VR-Chain 2775 10417, 18059, 25701, 33343, 40985,48627, 56269 anti-HIV_048-005532_VR-Chain 2776 10418, 18060, 25702,33344, 40986, 48628, 56270 anti-HIV_048-005189_VR-Chain 2777 10419,18061, 25703, 33345, 40987, 48629, 56271 anti-HIV_048-005088_VR-Chain2778 10420, 18062, 25704, 33346, 40988, 48630, 56272anti-HIV_048-004023_VR-Chain 2779 10421, 18063, 25705, 33347, 40989,48631, 56273 anti-HIV_048-001580_VR-Chain 2780 10422, 18064, 25706,33348, 40990, 48632, 56274 anti-HIV_038-221120_VR-Chain 2781 10423,18065, 25707, 33349, 40991, 48633, 56275 anti-HIV_038-197677_VR-Chain2782 10424, 18066, 25708, 33350, 40992, 48634, 56276anti-HIV_038-196765_VR-Chain 2783 10425, 18067, 25709, 33351, 40993,48635, 56277 anti-HIV_038-186200_VR-Chain 2784 10426, 18068, 25710,33352, 40994, 48636, 56278 anti-HIV_038-126170_VR-Chain 2785 10427,18069, 25711, 33353, 40995, 48637, 56279 anti-HIV_038-108545_VR-Chain2786 10428, 18070, 25712, 33354, 40996, 48638, 56280anti-HIV_038-107263_VR-Chain 2787 10429, 18071, 25713, 33355, 40997,48639, 56281 anti-HIV_038-104530_VR-Chain 2788 10430, 18072, 25714,33356, 40998, 48640, 56282 anti-HIV_038-099169_VR-Chain 2789 10431,18073, 25715, 33357, 40999, 48641, 56283 anti-HIV_038-075067_VR-Chain2790 10432, 18074, 25716, 33358, 41000, 48642, 56284anti-HIV_038-072368_VR-Chain 2791 10433, 18075, 25717, 33359, 41001,48643, 56285 anti-HIV_038-068503_VR-Chain 2792 10434, 18076, 25718,33360, 41002, 48644, 56286 anti-HIV_038-068016_VR-Chain 2793 10435,18077, 25719, 33361, 41003, 48645, 56287 anti-HIV_038-063958_VR-Chain2794 10436, 18078, 25720, 33362, 41004, 48646, 56288anti-HIV_038-033733_VR-Chain 2795 10437, 18079, 25721, 33363, 41005,48647, 56289 anti-HIV_038-030557_VR-Chain 2796 10438, 18080, 25722,33364, 41006, 48648, 56290 anti-HIV_038-024298_VR-Chain 2797 10439,18081, 25723, 33365, 41007, 48649, 56291 anti-HIV_038-011154_VR-Chain2798 10440, 18082, 25724, 33366, 41008, 48650, 56292anti-HIV-1_LightChain 2799 10441, 18083, 25725, 33367, 41009, 48651,56293 anti-HIV-1_LightChain 2800 10442, 18084, 25726, 33368, 41010,48652, 56294 anti-HIV-1_LightChain 2801 10443, 18085, 25727, 33369,41011, 48653, 56295 anti-HIV-1_LightChain 2802 10444, 18086, 25728,33370, 41012, 48654, 56296 anti-HIV-1_LightChain 2803 10445, 18087,25729, 33371, 41013, 48655, 56297 anti-HIV-1_LightChain 2804 10446,18088, 25730, 33372, 41014, 48656, 56298 anti-HIV-1_LightChain 280510447, 18089, 25731, 33373, 41015, 48657, 56299 anti-HIV-1_LightChain2806 10448, 18090, 25732, 33374, 41016, 48658, 56300anti-HIV-1_LightChain 2807 10449, 18091, 25733, 33375, 41017, 48659,56301 anti-HIV-1_LightChain 2808 10450, 18092, 25734, 33376, 41018,48660, 56302 anti-HIV-1_LightChain 2809 10451, 18093, 25735, 33377,41019, 48661, 56303 anti-HIV-1_LightChain 2810 10452, 18094, 25736,33378, 41020, 48662, 56304 anti-HIV-1_LightChain 2811 10453, 18095,25737, 33379, 41021, 48663, 56305 anti-HIV-1_LightChain 2812 10454,18096, 25738, 33380, 41022, 48664, 56306 anti-HIV-1_LightChain 281310455, 18097, 25739, 33381, 41023, 48665, 56307 anti-HIV-1_LightChain2814 10456, 18098, 25740, 33382, 41024, 48666, 56308anti-HIV-1_LightChain 2815 10457, 18099, 25741, 33383, 41025, 48667,56309 anti-HIV-1_LightChain 2816 10458, 18100, 25742, 33384, 41026,48668, 56310 anti-HIV-1_LightChain 2817 10459, 18101, 25743, 33385,41027, 48669, 56311 anti-HIV-1_LightChain 2818 10460, 18102, 25744,33386, 41028, 48670, 56312 anti-HIV-1_LightChain 2819 10461, 18103,25745, 33387, 41029, 48671, 56313 anti-HIV-1_LightChain 2820 10462,18104, 25746, 33388, 41030, 48672, 56314 anti-HIV-1_HeavyChain 282110463, 18105, 25747, 33389, 41031, 48673, 56315 anti-HIV-1_HeavyChain2822 10464, 18106, 25748, 33390, 41032, 48674, 56316anti-HIV-1_HeavyChain 2823 10465, 18107, 25749, 33391, 41033, 48675,56317 anti-HIV-1_HeavyChain 2824 10466, 18108, 25750, 33392, 41034,48676, 56318 anti-HIV-1_HeavyChain 2825 10467, 18109, 25751, 33393,41035, 48677, 56319 anti-HIV-1_HeavyChain 2826 10468, 18110, 25752,33394, 41036, 48678, 56320 anti-HIV-1_HeavyChain 2827 10469, 18111,25753, 33395, 41037, 48679, 56321 anti-HIV-1_HeavyChain 2828 10470,18112, 25754, 33396, 41038, 48680, 56322 anti-HIV-1_HeavyChain 282910471, 18113, 25755, 33397, 41039, 48681, 56323 anti-HIV-1_HeavyChain2830 10472, 18114, 25756, 33398, 41040, 48682, 56324anti-HIV-1_HeavyChain 2831 10473, 18115, 25757, 33399, 41041, 48683,56325 anti-HIV-1_HeavyChain 2832 10474, 18116, 25758, 33400, 41042,48684, 56326 anti-HIV-1_HeavyChain 2833 10475, 18117, 25759, 33401,41043, 48685, 56327 anti-HIV-1_HeavyChain 2834 10476, 18118, 25760,33402, 41044, 48686, 56328 anti-HIV-1_HeavyChain 2835 10477, 18119,25761, 33403, 41045, 48687, 56329 anti-HIV-1_HeavyChain 2836 10478,18120, 25762, 33404, 41046, 48688, 56330 anti-HIV-1_HeavyChain 283710479, 18121, 25763, 33405, 41047, 48689, 56331 anti-HIV-1_HeavyChain2838 10480, 18122, 25764, 33406, 41048, 48690, 56332anti-HIV-1_HeavyChain 2839 10481, 18123, 25765, 33407, 41049, 48691,56333 anti-HIV-1_HeavyChain 2840 10482, 18124, 25766, 33408, 41050,48692, 56334 anti-HIV-1_HeavyChain 2841 10483, 18125, 25767, 33409,41051, 48693, 56335 anti-HIV-1_HeavyChain 2842 10484, 18126, 25768,33410, 41052, 48694, 56336 anti-HIV-1_HeavyChain 2843 10485, 18127,25769, 33411, 41053, 48695, 56337 anti-HIV-1_HeavyChain 2844 10486,18128, 25770, 33412, 41054, 48696, 56338 anti-HIV-1_HeavyChain 284510487, 18129, 25771, 33413, 41055, 48697, 56339 anti-HIV-1_HeavyChain2846 10488, 18130, 25772, 33414, 41056, 48698, 56340anti-HIV-1_HeavyChain 2847 10489, 18131, 25773, 33415, 41057, 48699,56341 anti-HIV-1_LightChain 2848 10490, 18132, 25774, 33416, 41058,48700, 56342 anti-HIV-1_HeavyChain 2849 10491, 18133, 25775, 33417,41059, 48701, 56343 anti-HIV-1_HeavyChain 2850 10492, 18134, 25776,33418, 41060, 48702, 56344 anti-HIV-1_HeavyChain 2851 10493, 18135,25777, 33419, 41061, 48703, 56345 anti-HIV-1_HeavyChain 2852 10494,18136, 25778, 33420, 41062, 48704, 56346 anti-HIV-1_HeavyChain 285310495, 18137, 25779, 33421, 41063, 48705, 56347 anti-HIV-1_HeavyChain2854 10496, 18138, 25780, 33422, 41064, 48706, 56348anti-HIV-1_HeavyChain 2855 10497, 18139, 25781, 33423, 41065, 48707,56349 anti-HIV-1_HeavyChain 2856 10498, 18140, 25782, 33424, 41066,48708, 56350 anti-HIV-1_HeavyChain 2857 10499, 18141, 25783, 33425,41067, 48709, 56351 anti-HIV-1_HeavyChain 2858 10500, 18142, 25784,33426, 41068, 48710, 56352 anti-HIV-1_HeavyChain 2859 10501, 18143,25785, 33427, 41069, 48711, 56353 anti-HIV-1_HeavyChain 2860 10502,18144, 25786, 33428, 41070, 48712, 56354 anti-HIV-1_HeavyChain 286110503, 18145, 25787, 33429, 41071, 48713, 56355 anti-HIV-1_HeavyChain2862 10504, 18146, 25788, 33430, 41072, 48714, 56356anti-HIV-1_HeavyChain 2863 10505, 18147, 25789, 33431, 41073, 48715,56357 anti-HIV-1_HeavyChain 2864 10506, 18148, 25790, 33432, 41074,48716, 56358 anti-HIV-1_HeavyChain 2865 10507, 18149, 25791, 33433,41075, 48717, 56359 anti-HIV-1_HeavyChain 2866 10508, 18150, 25792,33434, 41076, 48718, 56360 anti-HIV-1_HeavyChain 2867 10509, 18151,25793, 33435, 41077, 48719, 56361 anti-HIV-1_HeavyChain 2868 10510,18152, 25794, 33436, 41078, 48720, 56362 anti-HIV-1_HeavyChain 286910511, 18153, 25795, 33437, 41079, 48721, 56363 anti-HIV-1_HeavyChain2870 10512, 18154, 25796, 33438, 41080, 48722, 56364anti-HIV-1_HeavyChain 2871 10513, 18155, 25797, 33439, 41081, 48723,56365 anti-HIV-1_HeavyChain 2872 10514, 18156, 25798, 33440, 41082,48724, 56366 anti-HIV-1_HeavyChain 2873 10515, 18157, 25799, 33441,41083, 48725, 56367 anti-HIV-1_HeavyChain 2874 10516, 18158, 25800,33442, 41084, 48726, 56368 anti-HIV-1_HeavyChain 2875 10517, 18159,25801, 33443, 41085, 48727, 56369 anti-HIV-1_HeavyChain 2876 10518,18160, 25802, 33444, 41086, 48728, 56370 anti-HIV-1_HeavyChain 287710519, 18161, 25803, 33445, 41087, 48729, 56371 anti-HIV-1_HeavyChain2878 10520, 18162, 25804, 33446, 41088, 48730, 56372anti-HIV-1_HeavyChain 2879 10521, 18163, 25805, 33447, 41089, 48731,56373 anti-HIV-1_HeavyChain 2880 10522, 18164, 25806, 33448, 41090,48732, 56374 anti-HIV-1_HeavyChain 2881 10523, 18165, 25807, 33449,41091, 48733, 56375 anti-HIV-1_HeavyChain 2882 10524, 18166, 25808,33450, 41092, 48734, 56376 anti-HIV-1_HeavyChain 2883 10525, 18167,25809, 33451, 41093, 48735, 56377 anti-HIV-1_HeavyChain 2884 10526,18168, 25810, 33452, 41094, 48736, 56378 anti-HIV-1_HeavyChain 288510527, 18169, 25811, 33453, 41095, 48737, 56379 anti-HIV-1_HeavyChain2886 10528, 18170, 25812, 33454, 41096, 48738, 56380anti-HIV-1_HeavyChain 2887 10529, 18171, 25813, 33455, 41097, 48739,56381 anti-HIV-1_HeavyChain 2888 10530, 18172, 25814, 33456, 41098,48740, 56382 anti-HIV-1_HeavyChain 2889 10531, 18173, 25815, 33457,41099, 48741, 56383 anti-HIV-1_HeavyChain 2890 10532, 18174, 25816,33458, 41100, 48742, 56384 anti-HIV-1_HeavyChain 2891 10533, 18175,25817, 33459, 41101, 48743, 56385 anti-HIV-1_HeavyChain 2892 10534,18176, 25818, 33460, 41102, 48744, 56386 anti-HIV-1_HeavyChain 289310535, 18177, 25819, 33461, 41103, 48745, 56387 anti-HIV-1_HeavyChain2894 10536, 18178, 25820, 33462, 41104, 48746, 56388anti-HIV-1_HeavyChain 2895 10537, 18179, 25821, 33463, 41105, 48747,56389 anti-HIV-1_HeavyChain 2896 10538, 18180, 25822, 33464, 41106,48748, 56390 anti-HIV-1_HeavyChain 2897 10539, 18181, 25823, 33465,41107, 48749, 56391 anti-HIV-1_HeavyChain 2898 10540, 18182, 25824,33466, 41108, 48750, 56392 anti-HIV-1_HeavyChain 2899 10541, 18183,25825, 33467, 41109, 48751, 56393 anti-HIV-1_HeavyChain 2900 10542,18184, 25826, 33468, 41110, 48752, 56394 anti-HIV-1_HeavyChain 290110543, 18185, 25827, 33469, 41111, 48753, 56395 anti-HIV-1_HeavyChain2902 10544, 18186, 25828, 33470, 41112, 48754, 56396anti-HIV-1_HeavyChain 2903 10545, 18187, 25829, 33471, 41113, 48755,56397 anti-HIV-1_HeavyChain 2904 10546, 18188, 25830, 33472, 41114,48756, 56398 anti-HIV-1_HeavyChain 2905 10547, 18189, 25831, 33473,41115, 48757, 56399 anti-HIV-1_HeavyChain 2906 10548, 18190, 25832,33474, 41116, 48758, 56400 anti-HIV-1_HeavyChain 2907 10549, 18191,25833, 33475, 41117, 48759, 56401 anti-HIV-1_HeavyChain 2908 10550,18192, 25834, 33476, 41118, 48760, 56402 anti-HIV-1_HeavyChain 290910551, 18193, 25835, 33477, 41119, 48761, 56403 anti-HIV-1_HeavyChain2910 10552, 18194, 25836, 33478, 41120, 48762, 56404anti-HIV-1_HeavyChain 2911 10553, 18195, 25837, 33479, 41121, 48763,56405 anti-HIV-1_HeavyChain 2912 10554, 18196, 25838, 33480, 41122,48764, 56406 anti-HIV-1_HeavyChain 2913 10555, 18197, 25839, 33481,41123, 48765, 56407 anti-HIV-1_HeavyChain 2914 10556, 18198, 25840,33482, 41124, 48766, 56408 anti-HIV-1_HeavyChain 2915 10557, 18199,25841, 33483, 41125, 48767, 56409 anti-HIV-1_HeavyChain 2916 10558,18200, 25842, 33484, 41126, 48768, 56410 anti-HIV-1_HeavyChain 291710559, 18201, 25843, 33485, 41127, 48769, 56411 anti-HIV-1_HeavyChain2918 10560, 18202, 25844, 33486, 41128, 48770, 56412anti-HIV-1_HeavyChain 2919 10561, 18203, 25845, 33487, 41129, 48771,56413 anti-HIV-1_HeavyChain 2920 10562, 18204, 25846, 33488, 41130,48772, 56414 anti-HIV-1_HeavyChain 2921 10563, 18205, 25847, 33489,41131, 48773, 56415 anti-HIV-1_HeavyChain 2922 10564, 18206, 25848,33490, 41132, 48774, 56416 anti-HIV-1_HeavyChain 2923 10565, 18207,25849, 33491, 41133, 48775, 56417 anti-HIV-1_HeavyChain 2924 10566,18208, 25850, 33492, 41134, 48776, 56418 anti-HIV-1_HeavyChain 292510567, 18209, 25851, 33493, 41135, 48777, 56419 anti-HIV-1_HeavyChain2926 10568, 18210, 25852, 33494, 41136, 48778, 56420anti-HIV-1_HeavyChain 2927 10569, 18211, 25853, 33495, 41137, 48779,56421 anti-HIV-1_HeavyChain 2928 10570, 18212, 25854, 33496, 41138,48780, 56422 anti-HIV-1_HeavyChain 2929 10571, 18213, 25855, 33497,41139, 48781, 56423 anti-HIV-1_HeavyChain 2930 10572, 18214, 25856,33498, 41140, 48782, 56424 anti-HIV-1_HeavyChain 2931 10573, 18215,25857, 33499, 41141, 48783, 56425 anti-HIV-1_HeavyChain 2932 10574,18216, 25858, 33500, 41142, 48784, 56426 anti-HIV-1_HeavyChain 293310575, 18217, 25859, 33501, 41143, 48785, 56427 anti-HIV-1_HeavyChain2934 10576, 18218, 25860, 33502, 41144, 48786, 56428anti-HIV-1_HeavyChain 2935 10577, 18219, 25861, 33503, 41145, 48787,56429 anti-HIV-1_HeavyChain 2936 10578, 18220, 25862, 33504, 41146,48788, 56430 anti-HIV-1_HeavyChain 2937 10579, 18221, 25863, 33505,41147, 48789, 56431 anti-HIV-1_HeavyChain 2938 10580, 18222, 25864,33506, 41148, 48790, 56432 anti-HIV-1_HeavyChain 2939 10581, 18223,25865, 33507, 41149, 48791, 56433 anti-HIV-1_HeavyChain 2940 10582,18224, 25866, 33508, 41150, 48792, 56434 anti-HIV-1_HeavyChain 294110583, 18225, 25867, 33509, 41151, 48793, 56435 anti-HIV-1_HeavyChain2942 10584, 18226, 25868, 33510, 41152, 48794, 56436anti-HIV-1_HeavyChain 2943 10585, 18227, 25869, 33511, 41153, 48795,56437 anti-HIV-1_HeavyChain 2944 10586, 18228, 25870, 33512, 41154,48796, 56438 anti-HIV-1_HeavyChain 2945 10587, 18229, 25871, 33513,41155, 48797, 56439 anti-HIV-1_HeavyChain 2946 10588, 18230, 25872,33514, 41156, 48798, 56440 anti-HIV-1_HeavyChain 2947 10589, 18231,25873, 33515, 41157, 48799, 56441 anti-HIV-1_HeavyChain 2948 10590,18232, 25874, 33516, 41158, 48800, 56442 anti-HIV-1_HeavyChain 294910591, 18233, 25875, 33517, 41159, 48801, 56443 anti-HIV-1_HeavyChain2950 10592, 18234, 25876, 33518, 41160, 48802, 56444anti-HIV-1_HeavyChain 2951 10593, 18235, 25877, 33519, 41161, 48803,56445 anti-HIV-1_HeavyChain 2952 10594, 18236, 25878, 33520, 41162,48804, 56446 anti-HIV-1_HeavyChain 2953 10595, 18237, 25879, 33521,41163, 48805, 56447 anti-HIV-1_HeavyChain 2954 10596, 18238, 25880,33522, 41164, 48806, 56448 anti-HIV-1_HeavyChain 2955 10597, 18239,25881, 33523, 41165, 48807, 56449 anti-HIV-1_HeavyChain 2956 10598,18240, 25882, 33524, 41166, 48808, 56450 anti-HIV-1_HeavyChain 295710599, 18241, 25883, 33525, 41167, 48809, 56451 anti-HIV-1_HeavyChain2958 10600, 18242, 25884, 33526, 41168, 48810, 56452anti-HIV-1_HeavyChain 2959 10601, 18243, 25885, 33527, 41169, 48811,56453 anti-HIV-1_HeavyChain 2960 10602, 18244, 25886, 33528, 41170,48812, 56454 anti-HIV-1_HeavyChain 2961 10603, 18245, 25887, 33529,41171, 48813, 56455 anti-HIV-1_HeavyChain 2962 10604, 18246, 25888,33530, 41172, 48814, 56456 anti-HIV-1_HeavyChain 2963 10605, 18247,25889, 33531, 41173, 48815, 56457 anti-HIV-1_HeavyChain 2964 10606,18248, 25890, 33532, 41174, 48816, 56458 anti-HIV-1_HeavyChain 296510607, 18249, 25891, 33533, 41175, 48817, 56459 anti-HIV-1_HeavyChain2966 10608, 18250, 25892, 33534, 41176, 48818, 56460anti-HIV-1_HeavyChain 2967 10609, 18251, 25893, 33535, 41177, 48819,56461 anti-HIV-1_HeavyChain 2968 10610, 18252, 25894, 33536, 41178,48820, 56462 anti-HIV-1_HeavyChain 2969 10611, 18253, 25895, 33537,41179, 48821, 56463 anti-HIV-1_HeavyChain 2970 10612, 18254, 25896,33538, 41180, 48822, 56464 anti-HIV-1_HeavyChain 2971 10613, 18255,25897, 33539, 41181, 48823, 56465 anti-HIV-1_HeavyChain 2972 10614,18256, 25898, 33540, 41182, 48824, 56466 anti-HIV-1_HeavyChain 297310615, 18257, 25899, 33541, 41183, 48825, 56467 anti-HIV-1_HeavyChain2974 10616, 18258, 25900, 33542, 41184, 48826, 56468anti-HIV-1_HeavyChain 2975 10617, 18259, 25901, 33543, 41185, 48827,56469 anti-HIV-1_HeavyChain 2976 10618, 18260, 25902, 33544, 41186,48828, 56470 anti-HIV-1_HeavyChain 2977 10619, 18261, 25903, 33545,41187, 48829, 56471 anti-HIV-1_HeavyChain 2978 10620, 18262, 25904,33546, 41188, 48830, 56472 anti-HIV-1_HeavyChain 2979 10621, 18263,25905, 33547, 41189, 48831, 56473 anti-HIV-1_HeavyChain 2980 10622,18264, 25906, 33548, 41190, 48832, 56474 anti-HIV-1_HeavyChain 298110623, 18265, 25907, 33549, 41191, 48833, 56475 anti-HIV-1_HeavyChain2982 10624, 18266, 25908, 33550, 41192, 48834, 56476anti-HIV-1_HeavyChain 2983 10625, 18267, 25909, 33551, 41193, 48835,56477 anti-HIV-1_HeavyChain 2984 10626, 18268, 25910, 33552, 41194,48836, 56478 anti-HIV-1_HeavyChain 2985 10627, 18269, 25911, 33553,41195, 48837, 56479 anti-HIV-1_HeavyChain 2986 10628, 18270, 25912,33554, 41196, 48838, 56480 anti-HIV-1_HeavyChain 2987 10629, 18271,25913, 33555, 41197, 48839, 56481 anti-HIV-1_HeavyChain 2988 10630,18272, 25914, 33556, 41198, 48840, 56482 anti-HIV-1_HeavyChain 298910631, 18273, 25915, 33557, 41199, 48841, 56483 anti-HIV-1_HeavyChain2990 10632, 18274, 25916, 33558, 41200, 48842, 56484anti-HIV-1_HeavyChain 2991 10633, 18275, 25917, 33559, 41201, 48843,56485 anti-HIV-1_HeavyChain 2992 10634, 18276, 25918, 33560, 41202,48844, 56486 anti-HIV-1_HeavyChain 2993 10635, 18277, 25919, 33561,41203, 48845, 56487 anti-HIV-1_HeavyChain 2994 10636, 18278, 25920,33562, 41204, 48846, 56488 anti-HIV-1_HeavyChain 2995 10637, 18279,25921, 33563, 41205, 48847, 56489 anti-HIV-1_HeavyChain 2996 10638,18280, 25922, 33564, 41206, 48848, 56490 anti-HIV-1_HeavyChain 299710639, 18281, 25923, 33565, 41207, 48849, 56491 anti-HIV-1_HeavyChain2998 10640, 18282, 25924, 33566, 41208, 48850, 56492anti-HIV-1_HeavyChain 2999 10641, 18283, 25925, 33567, 41209, 48851,56493 anti-HIV-1_HeavyChain 3000 10642, 18284, 25926, 33568, 41210,48852, 56494 anti-HIV-1_HeavyChain 3001 10643, 18285, 25927, 33569,41211, 48853, 56495 anti-HIV-1_HeavyChain 3002 10644, 18286, 25928,33570, 41212, 48854, 56496 anti-HIV-1_HeavyChain 3003 10645, 18287,25929, 33571, 41213, 48855, 56497 anti-HIV-1_HeavyChain 3004 10646,18288, 25930, 33572, 41214, 48856, 56498 anti-HIV-1_HeavyChain 300510647, 18289, 25931, 33573, 41215, 48857, 56499 anti-HIV-1_HeavyChain3006 10648, 18290, 25932, 33574, 41216, 48858, 56500anti-HIV-1_HeavyChain 3007 10649, 18291, 25933, 33575, 41217, 48859,56501 anti-HIV-1_HeavyChain 3008 10650, 18292, 25934, 33576, 41218,48860, 56502 anti-HIV-1_HeavyChain 3009 10651, 18293, 25935, 33577,41219, 48861, 56503 anti-HIV-1_HeavyChain 3010 10652, 18294, 25936,33578, 41220, 48862, 56504 anti-HIV-1_HeavyChain 3011 10653, 18295,25937, 33579, 41221, 48863, 56505 anti-HIV-1_HeavyChain 3012 10654,18296, 25938, 33580, 41222, 48864, 56506 anti-HIV-1_HeavyChain 301310655, 18297, 25939, 33581, 41223, 48865, 56507 anti-HIV-1_HeavyChain3014 10656, 18298, 25940, 33582, 41224, 48866, 56508anti-HIV-1_HeavyChain 3015 10657, 18299, 25941, 33583, 41225, 48867,56509 anti-HIV-1_HeavyChain 3016 10658, 18300, 25942, 33584, 41226,48868, 56510 anti-HIV-1_HeavyChain 3017 10659, 18301, 25943, 33585,41227, 48869, 56511 anti-HIV-1_HeavyChain 3018 10660, 18302, 25944,33586, 41228, 48870, 56512 anti-HIV-1_HeavyChain 3019 10661, 18303,25945, 33587, 41229, 48871, 56513 anti-HIV-1_HeavyChain 3020 10662,18304, 25946, 33588, 41230, 48872, 56514 anti-HIV-1_HeavyChain 302110663, 18305, 25947, 33589, 41231, 48873, 56515 anti-HIV-1_HeavyChain3022 10664, 18306, 25948, 33590, 41232, 48874, 56516anti-HIV-1_HeavyChain 3023 10665, 18307, 25949, 33591, 41233, 48875,56517 anti-HIV-1_HeavyChain 3024 10666, 18308, 25950, 33592, 41234,48876, 56518 anti-HIV-1_HeavyChain 3025 10667, 18309, 25951, 33593,41235, 48877, 56519 anti-HIV-1_HeavyChain 3026 10668, 18310, 25952,33594, 41236, 48878, 56520 anti-HIV-1_HeavyChain 3027 10669, 18311,25953, 33595, 41237, 48879, 56521 anti-HIV-1_HeavyChain 3028 10670,18312, 25954, 33596, 41238, 48880, 56522 anti-HIV-1_HeavyChain 302910671, 18313, 25955, 33597, 41239, 48881, 56523 anti-HIV-1_HeavyChain3030 10672, 18314, 25956, 33598, 41240, 48882, 56524anti-HIV-1_HeavyChain 3031 10673, 18315, 25957, 33599, 41241, 48883,56525 anti-HIV-1_HeavyChain 3032 10674, 18316, 25958, 33600, 41242,48884, 56526 anti-HIV-1_HeavyChain 3033 10675, 18317, 25959, 33601,41243, 48885, 56527 anti-HIV-1_HeavyChain 3034 10676, 18318, 25960,33602, 41244, 48886, 56528 anti-HIV-1_HeavyChain 3035 10677, 18319,25961, 33603, 41245, 48887, 56529 anti-HIV-1_HeavyChain 3036 10678,18320, 25962, 33604, 41246, 48888, 56530 anti-HIV-1_HeavyChain 303710679, 18321, 25963, 33605, 41247, 48889, 56531 anti-HIV-1_HeavyChain3038 10680, 18322, 25964, 33606, 41248, 48890, 56532anti-HIV-1_HeavyChain 3039 10681, 18323, 25965, 33607, 41249, 48891,56533 anti-HIV-1_HeavyChain 3040 10682, 18324, 25966, 33608, 41250,48892, 56534 anti-HIV-1_HeavyChain 3041 10683, 18325, 25967, 33609,41251, 48893, 56535 anti-HIV-1_HeavyChain 3042 10684, 18326, 25968,33610, 41252, 48894, 56536 anti-HIV-1_HeavyChain 3043 10685, 18327,25969, 33611, 41253, 48895, 56537 anti-HIV-1_HeavyChain 3044 10686,18328, 25970, 33612, 41254, 48896, 56538 anti-HIV-1_HeavyChain 304510687, 18329, 25971, 33613, 41255, 48897, 56539 anti-HIV-1_HeavyChain3046 10688, 18330, 25972, 33614, 41256, 48898, 56540anti-HIV-1_HeavyChain 3047 10689, 18331, 25973, 33615, 41257, 48899,56541 anti-HIV-1_HeavyChain 3048 10690, 18332, 25974, 33616, 41258,48900, 56542 anti-HIV-1_HeavyChain 3049 10691, 18333, 25975, 33617,41259, 48901, 56543 anti-HIV-1_HeavyChain 3050 10692, 18334, 25976,33618, 41260, 48902, 56544 anti-HIV-1_HeavyChain 3051 10693, 18335,25977, 33619, 41261, 48903, 56545 anti-HIV-1_HeavyChain 3052 10694,18336, 25978, 33620, 41262, 48904, 56546 anti-HIV-1_HeavyChain 305310695, 18337, 25979, 33621, 41263, 48905, 56547 anti-HIV-1_HeavyChain3054 10696, 18338, 25980, 33622, 41264, 48906, 56548anti-HIV-1_HeavyChain 3055 10697, 18339, 25981, 33623, 41265, 48907,56549 anti-HIV-1_HeavyChain 3056 10698, 18340, 25982, 33624, 41266,48908, 56550 anti-HIV-1_HeavyChain 3057 10699, 18341, 25983, 33625,41267, 48909, 56551 anti-HIV-1_HeavyChain 3058 10700, 18342, 25984,33626, 41268, 48910, 56552 anti-HIV-1_HeavyChain 3059 10701, 18343,25985, 33627, 41269, 48911, 56553 anti-HIV-1_HeavyChain 3060 10702,18344, 25986, 33628, 41270, 48912, 56554 anti-HIV-1_HeavyChain 306110703, 18345, 25987, 33629, 41271, 48913, 56555 anti-HIV-1_HeavyChain3062 10704, 18346, 25988, 33630, 41272, 48914, 56556anti-HIV-1_HeavyChain 3063 10705, 18347, 25989, 33631, 41273, 48915,56557 anti-HIV-1_HeavyChain 3064 10706, 18348, 25990, 33632, 41274,48916, 56558 anti-HIV-1_HeavyChain 3065 10707, 18349, 25991, 33633,41275, 48917, 56559 anti-HIV-1_HeavyChain 3066 10708, 18350, 25992,33634, 41276, 48918, 56560 anti-HIV-1_HeavyChain 3067 10709, 18351,25993, 33635, 41277, 48919, 56561 anti-HIV-1_HeavyChain 3068 10710,18352, 25994, 33636, 41278, 48920, 56562 anti-HIV-1_HeavyChain 306910711, 18353, 25995, 33637, 41279, 48921, 56563 anti-HIV-1_HeavyChain3070 10712, 18354, 25996, 33638, 41280, 48922, 56564anti-HIV-1_HeavyChain 3071 10713, 18355, 25997, 33639, 41281, 48923,56565 anti-HIV-1_HeavyChain 3072 10714, 18356, 25998, 33640, 41282,48924, 56566 anti-HIV-1_HeavyChain 3073 10715, 18357, 25999, 33641,41283, 48925, 56567 anti-HIV-1_HeavyChain 3074 10716, 18358, 26000,33642, 41284, 48926, 56568 anti-HIV-1_HeavyChain 3075 10717, 18359,26001, 33643, 41285, 48927, 56569 anti-HIV-1_HeavyChain 3076 10718,18360, 26002, 33644, 41286, 48928, 56570 anti-HIV-1_HeavyChain 307710719, 18361, 26003, 33645, 41287, 48929, 56571 anti-HIV-1_HeavyChain3078 10720, 18362, 26004, 33646, 41288, 48930, 56572anti-HIV-1_HeavyChain 3079 10721, 18363, 26005, 33647, 41289, 48931,56573 anti-HIV-1_HeavyChain 3080 10722, 18364, 26006, 33648, 41290,48932, 56574 anti-HIV-1_HeavyChain 3081 10723, 18365, 26007, 33649,41291, 48933, 56575 anti-HIV-1_HeavyChain 3082 10724, 18366, 26008,33650, 41292, 48934, 56576 anti-HIV-1_HeavyChain 3083 10725, 18367,26009, 33651, 41293, 48935, 56577 anti-HIV-1_HeavyChain 3084 10726,18368, 26010, 33652, 41294, 48936, 56578 anti-HIV-1_HeavyChain 308510727, 18369, 26011, 33653, 41295, 48937, 56579 anti-HIV-1_HeavyChain3086 10728, 18370, 26012, 33654, 41296, 48938, 56580anti-HIV-1_HeavyChain 3087 10729, 18371, 26013, 33655, 41297, 48939,56581 anti-HIV-1_HeavyChain 3088 10730, 18372, 26014, 33656, 41298,48940, 56582 anti-HIV-1_HeavyChain 3089 10731, 18373, 26015, 33657,41299, 48941, 56583 anti-HIV-1_HeavyChain 3090 10732, 18374, 26016,33658, 41300, 48942, 56584 anti-HIV-1_HeavyChain 3091 10733, 18375,26017, 33659, 41301, 48943, 56585 anti-HIV-1_HeavyChain 3092 10734,18376, 26018, 33660, 41302, 48944, 56586 anti-HIV-1_HeavyChain 309310735, 18377, 26019, 33661, 41303, 48945, 56587 anti-HIV-1_HeavyChain3094 10736, 18378, 26020, 33662, 41304, 48946, 56588anti-HIV-1_HeavyChain 3095 10737, 18379, 26021, 33663, 41305, 48947,56589 anti-HIV-1_HeavyChain 3096 10738, 18380, 26022, 33664, 41306,48948, 56590 anti-HIV-1_HeavyChain 3097 10739, 18381, 26023, 33665,41307, 48949, 56591 anti-HIV-1_HeavyChain 3098 10740, 18382, 26024,33666, 41308, 48950, 56592 anti-HIV-1_HeavyChain 3099 10741, 18383,26025, 33667, 41309, 48951, 56593 anti-HIV-1_HeavyChain 3100 10742,18384, 26026, 33668, 41310, 48952, 56594 anti-HIV-1_HeavyChain 310110743, 18385, 26027, 33669, 41311, 48953, 56595 anti-HIV-1_HeavyChain3102 10744, 18386, 26028, 33670, 41312, 48954, 56596anti-HIV-1_HeavyChain 3103 10745, 18387, 26029, 33671, 41313, 48955,56597 anti-HIV-1_HeavyChain 3104 10746, 18388, 26030, 33672, 41314,48956, 56598 anti-HIV-1_HeavyChain 3105 10747, 18389, 26031, 33673,41315, 48957, 56599 anti-HIV-1_HeavyChain 3106 10748, 18390, 26032,33674, 41316, 48958, 56600 anti-HIV-1_HeavyChain 3107 10749, 18391,26033, 33675, 41317, 48959, 56601 anti-HIV-1_HeavyChain 3108 10750,18392, 26034, 33676, 41318, 48960, 56602 anti-HIV-1_HeavyChain 310910751, 18393, 26035, 33677, 41319, 48961, 56603 anti-HIV-1_HeavyChain3110 10752, 18394, 26036, 33678, 41320, 48962, 56604anti-HIV-1_HeavyChain 3111 10753, 18395, 26037, 33679, 41321, 48963,56605 anti-HIV-1_HeavyChain 3112 10754, 18396, 26038, 33680, 41322,48964, 56606 anti-HIV-1_HeavyChain 3113 10755, 18397, 26039, 33681,41323, 48965, 56607 anti-HIV-1_HeavyChain 3114 10756, 18398, 26040,33682, 41324, 48966, 56608 anti-HIV-1_HeavyChain 3115 10757, 18399,26041, 33683, 41325, 48967, 56609 anti-HIV-1_HeavyChain 3116 10758,18400, 26042, 33684, 41326, 48968, 56610 anti-HIV-1_HeavyChain 311710759, 18401, 26043, 33685, 41327, 48969, 56611 anti-HIV-1_HeavyChain3118 10760, 18402, 26044, 33686, 41328, 48970, 56612anti-HIV-1_HeavyChain 3119 10761, 18403, 26045, 33687, 41329, 48971,56613 anti-HIV-1_HeavyChain 3120 10762, 18404, 26046, 33688, 41330,48972, 56614 anti-HIV-1_HeavyChain 3121 10763, 18405, 26047, 33689,41331, 48973, 56615 anti-HIV-1_HeavyChain 3122 10764, 18406, 26048,33690, 41332, 48974, 56616 anti-HIV-1_HeavyChain 3123 10765, 18407,26049, 33691, 41333, 48975, 56617 anti-HIV-1_HeavyChain 3124 10766,18408, 26050, 33692, 41334, 48976, 56618 anti-HIV-1_HeavyChain 312510767, 18409, 26051, 33693, 41335, 48977, 56619 anti-HIV-1_HeavyChain3126 10768, 18410, 26052, 33694, 41336, 48978, 56620anti-HIV-1_HeavyChain 3127 10769, 18411, 26053, 33695, 41337, 48979,56621 anti-HIV-1_HeavyChain 3128 10770, 18412, 26054, 33696, 41338,48980, 56622 anti-HIV-1_HeavyChain 3129 10771, 18413, 26055, 33697,41339, 48981, 56623 anti-HIV-1_HeavyChain 3130 10772, 18414, 26056,33698, 41340, 48982, 56624 anti-HIV-1_HeavyChain 3131 10773, 18415,26057, 33699, 41341, 48983, 56625 anti-HIV-1_HeavyChain 3132 10774,18416, 26058, 33700, 41342, 48984, 56626 anti-HIV-1_HeavyChain 313310775, 18417, 26059, 33701, 41343, 48985, 56627 anti-HIV-1_HeavyChain3134 10776, 18418, 26060, 33702, 41344, 48986, 56628anti-HIV-1_HeavyChain 3135 10777, 18419, 26061, 33703, 41345, 48987,56629 anti-HIV-1_HeavyChain 3136 10778, 18420, 26062, 33704, 41346,48988, 56630 anti-HIV-1_HeavyChain 3137 10779, 18421, 26063, 33705,41347, 48989, 56631 anti-HIV-1_HeavyChain 3138 10780, 18422, 26064,33706, 41348, 48990, 56632 anti-HIV-1_HeavyChain 3139 10781, 18423,26065, 33707, 41349, 48991, 56633 anti-HIV-1_HeavyChain 3140 10782,18424, 26066, 33708, 41350, 48992, 56634 anti-HIV-1_HeavyChain 314110783, 18425, 26067, 33709, 41351, 48993, 56635 anti-HIV-1_HeavyChain3142 10784, 18426, 26068, 33710, 41352, 48994, 56636anti-HIV-1_HeavyChain 3143 10785, 18427, 26069, 33711, 41353, 48995,56637 anti-HIV-1_HeavyChain 3144 10786, 18428, 26070, 33712, 41354,48996, 56638 anti-HIV-1_HeavyChain 3145 10787, 18429, 26071, 33713,41355, 48997, 56639 anti-HIV-1_HeavyChain 3146 10788, 18430, 26072,33714, 41356, 48998, 56640 anti-HIV-1_HeavyChain 3147 10789, 18431,26073, 33715, 41357, 48999, 56641 anti-HIV-1_HeavyChain 3148 10790,18432, 26074, 33716, 41358, 49000, 56642 anti-HIV-1_HeavyChain 314910791, 18433, 26075, 33717, 41359, 49001, 56643 anti-HIV-1_HeavyChain3150 10792, 18434, 26076, 33718, 41360, 49002, 56644anti-HIV-1_HeavyChain 3151 10793, 18435, 26077, 33719, 41361, 49003,56645 anti-HIV-1_HeavyChain 3152 10794, 18436, 26078, 33720, 41362,49004, 56646 anti-HIV-1_HeavyChain 3153 10795, 18437, 26079, 33721,41363, 49005, 56647 anti-HIV-1_HeavyChain 3154 10796, 18438, 26080,33722, 41364, 49006, 56648 anti-HIV-1_HeavyChain 3155 10797, 18439,26081, 33723, 41365, 49007, 56649 anti-HIV-1_HeavyChain 3156 10798,18440, 26082, 33724, 41366, 49008, 56650 anti-HIV-1_HeavyChain 315710799, 18441, 26083, 33725, 41367, 49009, 56651 anti-HIV-1_HeavyChain3158 10800, 18442, 26084, 33726, 41368, 49010, 56652anti-HIV-1_HeavyChain 3159 10801, 18443, 26085, 33727, 41369, 49011,56653 anti-HIV-1_HeavyChain 3160 10802, 18444, 26086, 33728, 41370,49012, 56654 anti-HIV-1_HeavyChain 3161 10803, 18445, 26087, 33729,41371, 49013, 56655 anti-HIV-1_HeavyChain 3162 10804, 18446, 26088,33730, 41372, 49014, 56656 anti-HIV-1_HeavyChain 3163 10805, 18447,26089, 33731, 41373, 49015, 56657 anti-HIV-1_HeavyChain 3164 10806,18448, 26090, 33732, 41374, 49016, 56658 anti-HIV-1_HeavyChain 316510807, 18449, 26091, 33733, 41375, 49017, 56659 anti-HIV-1_HeavyChain3166 10808, 18450, 26092, 33734, 41376, 49018, 56660anti-HIV-1_HeavyChain 3167 10809, 18451, 26093, 33735, 41377, 49019,56661 anti-HIV-1_HeavyChain 3168 10810, 18452, 26094, 33736, 41378,49020, 56662 anti-HIV-1_HeavyChain 3169 10811, 18453, 26095, 33737,41379, 49021, 56663 anti-HIV-1_HeavyChain 3170 10812, 18454, 26096,33738, 41380, 49022, 56664 anti-HIV-1_HeavyChain 3171 10813, 18455,26097, 33739, 41381, 49023, 56665 anti-HIV-1_HeavyChain 3172 10814,18456, 26098, 33740, 41382, 49024, 56666 anti-HIV-1_HeavyChain 317310815, 18457, 26099, 33741, 41383, 49025, 56667 anti-HIV-1_HeavyChain3174 10816, 18458, 26100, 33742, 41384, 49026, 56668anti-HIV-1_HeavyChain 3175 10817, 18459, 26101, 33743, 41385, 49027,56669 anti-HIV-1_HeavyChain 3176 10818, 18460, 26102, 33744, 41386,49028, 56670 anti-HIV-1_HeavyChain 3177 10819, 18461, 26103, 33745,41387, 49029, 56671 anti-HIV-1_HeavyChain 3178 10820, 18462, 26104,33746, 41388, 49030, 56672 anti-HIV-1_HeavyChain 3179 10821, 18463,26105, 33747, 41389, 49031, 56673 anti-HIV-1_HeavyChain 3180 10822,18464, 26106, 33748, 41390, 49032, 56674 anti-HIV-1_HeavyChain 318110823, 18465, 26107, 33749, 41391, 49033, 56675 anti-HIV-1_HeavyChain3182 10824, 18466, 26108, 33750, 41392, 49034, 56676anti-HIV-1_HeavyChain 3183 10825, 18467, 26109, 33751, 41393, 49035,56677 anti-HIV-1_HeavyChain 3184 10826, 18468, 26110, 33752, 41394,49036, 56678 anti-HIV-1_HeavyChain 3185 10827, 18469, 26111, 33753,41395, 49037, 56679 anti-HIV-1_HeavyChain 3186 10828, 18470, 26112,33754, 41396, 49038, 56680 anti-HIV-1_HeavyChain 3187 10829, 18471,26113, 33755, 41397, 49039, 56681 anti-HIV-1_HeavyChain 3188 10830,18472, 26114, 33756, 41398, 49040, 56682 anti-HIV-1_HeavyChain 318910831, 18473, 26115, 33757, 41399, 49041, 56683 anti-HIV-1_HeavyChain3190 10832, 18474, 26116, 33758, 41400, 49042, 56684anti-HIV-1_HeavyChain 3191 10833, 18475, 26117, 33759, 41401, 49043,56685 anti-HIV-1_HeavyChain 3192 10834, 18476, 26118, 33760, 41402,49044, 56686 anti-HIV-1_HeavyChain 3193 10835, 18477, 26119, 33761,41403, 49045, 56687 anti-HIV-1_HeavyChain 3194 10836, 18478, 26120,33762, 41404, 49046, 56688 anti-HIV-1_HeavyChain 3195 10837, 18479,26121, 33763, 41405, 49047, 56689 anti-HIV-1_HeavyChain 3196 10838,18480, 26122, 33764, 41406, 49048, 56690 anti-HIV-1_HeavyChain 319710839, 18481, 26123, 33765, 41407, 49049, 56691 anti-HIV-1_HeavyChain3198 10840, 18482, 26124, 33766, 41408, 49050, 56692anti-HIV-1_HeavyChain 3199 10841, 18483, 26125, 33767, 41409, 49051,56693 anti-HIV-1_HeavyChain 3200 10842, 18484, 26126, 33768, 41410,49052, 56694 anti-HIV-1_HeavyChain 3201 10843, 18485, 26127, 33769,41411, 49053, 56695 anti-HIV-1_HeavyChain 3202 10844, 18486, 26128,33770, 41412, 49054, 56696 anti-HIV-1_HeavyChain 3203 10845, 18487,26129, 33771, 41413, 49055, 56697 anti-HIV-1_HeavyChain 3204 10846,18488, 26130, 33772, 41414, 49056, 56698 anti-HIV-1_HeavyChain 320510847, 18489, 26131, 33773, 41415, 49057, 56699 anti-HIV-1_HeavyChain3206 10848, 18490, 26132, 33774, 41416, 49058, 56700anti-HIV-1_HeavyChain 3207 10849, 18491, 26133, 33775, 41417, 49059,56701 anti-HIV-1_HeavyChain 3208 10850, 18492, 26134, 33776, 41418,49060, 56702 anti-HIV-1_HeavyChain 3209 10851, 18493, 26135, 33777,41419, 49061, 56703 anti-HIV-1_HeavyChain 3210 10852, 18494, 26136,33778, 41420, 49062, 56704 anti-HIV-1_HeavyChain 3211 10853, 18495,26137, 33779, 41421, 49063, 56705 anti-HIV-1_HeavyChain 3212 10854,18496, 26138, 33780, 41422, 49064, 56706 anti-HIV-1_HeavyChain 321310855, 18497, 26139, 33781, 41423, 49065, 56707 anti-HIV-1_HeavyChain3214 10856, 18498, 26140, 33782, 41424, 49066, 56708anti-HIV-1_HeavyChain 3215 10857, 18499, 26141, 33783, 41425, 49067,56709 anti-HIV-1_HeavyChain 3216 10858, 18500, 26142, 33784, 41426,49068, 56710 anti-HIV-1_HeavyChain 3217 10859, 18501, 26143, 33785,41427, 49069, 56711 anti-HIV-1_HeavyChain 3218 10860, 18502, 26144,33786, 41428, 49070, 56712 anti-HIV-1_HeavyChain 3219 10861, 18503,26145, 33787, 41429, 49071, 56713 anti-HIV-1_HeavyChain 3220 10862,18504, 26146, 33788, 41430, 49072, 56714 anti-HIV-1_HeavyChain 322110863, 18505, 26147, 33789, 41431, 49073, 56715 anti-HIV-1_HeavyChain3222 10864, 18506, 26148, 33790, 41432, 49074, 56716anti-HIV-1_HeavyChain 3223 10865, 18507, 26149, 33791, 41433, 49075,56717 anti-HIV-1_HeavyChain 3224 10866, 18508, 26150, 33792, 41434,49076, 56718 anti-HIV-1_HeavyChain 3225 10867, 18509, 26151, 33793,41435, 49077, 56719 anti-HIV-1_HeavyChain 3226 10868, 18510, 26152,33794, 41436, 49078, 56720 anti-HIV-1_HeavyChain 3227 10869, 18511,26153, 33795, 41437, 49079, 56721 anti-HIV-1_HeavyChain 3228 10870,18512, 26154, 33796, 41438, 49080, 56722 anti-HIV-1_HeavyChain 322910871, 18513, 26155, 33797, 41439, 49081, 56723 anti-HIV-1_HeavyChain3230 10872, 18514, 26156, 33798, 41440, 49082, 56724anti-HIV-1_HeavyChain 3231 10873, 18515, 26157, 33799, 41441, 49083,56725 anti-HIV-1_HeavyChain 3232 10874, 18516, 26158, 33800, 41442,49084, 56726 anti-HIV-1_HeavyChain 3233 10875, 18517, 26159, 33801,41443, 49085, 56727 anti-HIV-1_HeavyChain 3234 10876, 18518, 26160,33802, 41444, 49086, 56728 anti-HIV-1_HeavyChain 3235 10877, 18519,26161, 33803, 41445, 49087, 56729 anti-HIV-1_HeavyChain 3236 10878,18520, 26162, 33804, 41446, 49088, 56730 anti-HIV-1_HeavyChain 323710879, 18521, 26163, 33805, 41447, 49089, 56731 anti-HIV-1_HeavyChain3238 10880, 18522, 26164, 33806, 41448, 49090, 56732anti-HIV-1_HeavyChain 3239 10881, 18523, 26165, 33807, 41449, 49091,56733 anti-HIV-1_HeavyChain 3240 10882, 18524, 26166, 33808, 41450,49092, 56734 anti-HIV-1_HeavyChain 3241 10883, 18525, 26167, 33809,41451, 49093, 56735 anti-HIV-1_HeavyChain 3242 10884, 18526, 26168,33810, 41452, 49094, 56736 anti-HIV-1_HeavyChain 3243 10885, 18527,26169, 33811, 41453, 49095, 56737 anti-HIV-1_HeavyChain 3244 10886,18528, 26170, 33812, 41454, 49096, 56738 anti-HIV-1_HeavyChain 324510887, 18529, 26171, 33813, 41455, 49097, 56739 anti-HIV-1_HeavyChain3246 10888, 18530, 26172, 33814, 41456, 49098, 56740anti-HIV-1_HeavyChain 3247 10889, 18531, 26173, 33815, 41457, 49099,56741 anti-HIV-1_HeavyChain 3248 10890, 18532, 26174, 33816, 41458,49100, 56742 anti-HIV-1_HeavyChain 3249 10891, 18533, 26175, 33817,41459, 49101, 56743 anti-HIV-1_HeavyChain 3250 10892, 18534, 26176,33818, 41460, 49102, 56744 anti-HIV-1_HeavyChain 3251 10893, 18535,26177, 33819, 41461, 49103, 56745 anti-HIV-1_HeavyChain 3252 10894,18536, 26178, 33820, 41462, 49104, 56746 anti-HIV-1_HeavyChain 325310895, 18537, 26179, 33821, 41463, 49105, 56747 anti-HIV-1_HeavyChain3254 10896, 18538, 26180, 33822, 41464, 49106, 56748anti-HIV-1_HeavyChain 3255 10897, 18539, 26181, 33823, 41465, 49107,56749 anti-HIV-1_HeavyChain 3256 10898, 18540, 26182, 33824, 41466,49108, 56750 anti-HIV-1_HeavyChain 3257 10899, 18541, 26183, 33825,41467, 49109, 56751 anti-HIV-1_HeavyChain 3258 10900, 18542, 26184,33826, 41468, 49110, 56752 anti-HIV-1_HeavyChain 3259 10901, 18543,26185, 33827, 41469, 49111, 56753 anti-HIV-1_HeavyChain 3260 10902,18544, 26186, 33828, 41470, 49112, 56754 anti-HIV-1_HeavyChain 326110903, 18545, 26187, 33829, 41471, 49113, 56755 anti-HIV-1_HeavyChain3262 10904, 18546, 26188, 33830, 41472, 49114, 56756anti-HIV-1_HeavyChain 3263 10905, 18547, 26189, 33831, 41473, 49115,56757 anti-HIV-1_HeavyChain 3264 10906, 18548, 26190, 33832, 41474,49116, 56758 anti-HIV-1_HeavyChain 3265 10907, 18549, 26191, 33833,41475, 49117, 56759 anti-HIV-1_HeavyChain 3266 10908, 18550, 26192,33834, 41476, 49118, 56760 anti-HIV-1_HeavyChain 3267 10909, 18551,26193, 33835, 41477, 49119, 56761 anti-HIV-1_HeavyChain 3268 10910,18552, 26194, 33836, 41478, 49120, 56762 anti-HIV-1_HeavyChain 326910911, 18553, 26195, 33837, 41479, 49121, 56763 anti-HIV-1_HeavyChain3270 10912, 18554, 26196, 33838, 41480, 49122, 56764anti-HIV-1_HeavyChain 3271 10913, 18555, 26197, 33839, 41481, 49123,56765 anti-HIV-1_HeavyChain 3272 10914, 18556, 26198, 33840, 41482,49124, 56766 anti-HIV-1_HeavyChain 3273 10915, 18557, 26199, 33841,41483, 49125, 56767 anti-HIV-1_HeavyChain 3274 10916, 18558, 26200,33842, 41484, 49126, 56768 anti-HIV-1_HeavyChain 3275 10917, 18559,26201, 33843, 41485, 49127, 56769 anti-HIV-1_HeavyChain 3276 10918,18560, 26202, 33844, 41486, 49128, 56770 anti-HIV-1_HeavyChain 327710919, 18561, 26203, 33845, 41487, 49129, 56771 anti-HIV-1_HeavyChain3278 10920, 18562, 26204, 33846, 41488, 49130, 56772anti-HIV-1_HeavyChain 3279 10921, 18563, 26205, 33847, 41489, 49131,56773 anti-HIV-1_HeavyChain 3280 10922, 18564, 26206, 33848, 41490,49132, 56774 anti-HIV-1_HeavyChain 3281 10923, 18565, 26207, 33849,41491, 49133, 56775 anti-HIV-1_HeavyChain 3282 10924, 18566, 26208,33850, 41492, 49134, 56776 anti-HIV-1_HeavyChain 3283 10925, 18567,26209, 33851, 41493, 49135, 56777 anti-HIV-1_HeavyChain 3284 10926,18568, 26210, 33852, 41494, 49136, 56778 anti-HIV-1_HeavyChain 328510927, 18569, 26211, 33853, 41495, 49137, 56779 anti-HIV-1_HeavyChain3286 10928, 18570, 26212, 33854, 41496, 49138, 56780anti-HIV-1_HeavyChain 3287 10929, 18571, 26213, 33855, 41497, 49139,56781 anti-HIV-1_HeavyChain 3288 10930, 18572, 26214, 33856, 41498,49140, 56782 anti-HIV-1_HeavyChain 3289 10931, 18573, 26215, 33857,41499, 49141, 56783 anti-HIV-1_HeavyChain 3290 10932, 18574, 26216,33858, 41500, 49142, 56784 anti-HIV-1_HeavyChain 3291 10933, 18575,26217, 33859, 41501, 49143, 56785 anti-HIV-1_HeavyChain 3292 10934,18576, 26218, 33860, 41502, 49144, 56786 anti-HIV-1_HeavyChain 329310935, 18577, 26219, 33861, 41503, 49145, 56787 anti-HIV-1_HeavyChain3294 10936, 18578, 26220, 33862, 41504, 49146, 56788anti-HIV-1_HeavyChain 3295 10937, 18579, 26221, 33863, 41505, 49147,56789 anti-HIV-1_HeavyChain 3296 10938, 18580, 26222, 33864, 41506,49148, 56790 anti-HIV-1_HeavyChain 3297 10939, 18581, 26223, 33865,41507, 49149, 56791 anti-HIV-1_HeavyChain 3298 10940, 18582, 26224,33866, 41508, 49150, 56792 anti-HIV-1_HeavyChain 3299 10941, 18583,26225, 33867, 41509, 49151, 56793 anti-HIV-1_HeavyChain 3300 10942,18584, 26226, 33868, 41510, 49152, 56794 anti-HIV-1_HeavyChain 330110943, 18585, 26227, 33869, 41511, 49153, 56795 anti-HIV-1_HeavyChain3302 10944, 18586, 26228, 33870, 41512, 49154, 56796anti-HIV-1_HeavyChain 3303 10945, 18587, 26229, 33871, 41513, 49155,56797 anti-HIV-1_HeavyChain 3304 10946, 18588, 26230, 33872, 41514,49156, 56798 anti-HIV-1_HeavyChain 3305 10947, 18589, 26231, 33873,41515, 49157, 56799 anti-HIV-1_HeavyChain 3306 10948, 18590, 26232,33874, 41516, 49158, 56800 anti-HIV-1_HeavyChain 3307 10949, 18591,26233, 33875, 41517, 49159, 56801 anti-HIV-1_HeavyChain 3308 10950,18592, 26234, 33876, 41518, 49160, 56802 anti-HIV-1_HeavyChain 330910951, 18593, 26235, 33877, 41519, 49161, 56803 anti-HIV-1_HeavyChain3310 10952, 18594, 26236, 33878, 41520, 49162, 56804anti-HIV-1_HeavyChain 3311 10953, 18595, 26237, 33879, 41521, 49163,56805 anti-HIV-1_HeavyChain 3312 10954, 18596, 26238, 33880, 41522,49164, 56806 anti-HIV-1_HeavyChain 3313 10955, 18597, 26239, 33881,41523, 49165, 56807 anti-HIV-1_HeavyChain 3314 10956, 18598, 26240,33882, 41524, 49166, 56808 anti-HIV-1_HeavyChain 3315 10957, 18599,26241, 33883, 41525, 49167, 56809 anti-HIV-1_HeavyChain 3316 10958,18600, 26242, 33884, 41526, 49168, 56810 anti-HIV-1_HeavyChain 331710959, 18601, 26243, 33885, 41527, 49169, 56811 anti-HIV-1_HeavyChain3318 10960, 18602, 26244, 33886, 41528, 49170, 56812anti-HIV-1_HeavyChain 3319 10961, 18603, 26245, 33887, 41529, 49171,56813 anti-HIV-1_HeavyChain 3320 10962, 18604, 26246, 33888, 41530,49172, 56814 anti-HIV-1_HeavyChain 3321 10963, 18605, 26247, 33889,41531, 49173, 56815 anti-HIV-1_HeavyChain 3322 10964, 18606, 26248,33890, 41532, 49174, 56816 anti-HIV-1_HeavyChain 3323 10965, 18607,26249, 33891, 41533, 49175, 56817 anti-HIV-1_HeavyChain 3324 10966,18608, 26250, 33892, 41534, 49176, 56818 anti-HIV-1_HeavyChain 332510967, 18609, 26251, 33893, 41535, 49177, 56819 anti-HIV-1_HeavyChain3326 10968, 18610, 26252, 33894, 41536, 49178, 56820anti-HIV-1_HeavyChain 3327 10969, 18611, 26253, 33895, 41537, 49179,56821 anti-HIV-1_HeavyChain 3328 10970, 18612, 26254, 33896, 41538,49180, 56822 anti-HIV-1_HeavyChain 3329 10971, 18613, 26255, 33897,41539, 49181, 56823 anti-HIV-1_HeavyChain 3330 10972, 18614, 26256,33898, 41540, 49182, 56824 anti-HIV-1_HeavyChain 3331 10973, 18615,26257, 33899, 41541, 49183, 56825 anti-HIV-1_HeavyChain 3332 10974,18616, 26258, 33900, 41542, 49184, 56826 anti-HIV-1_HeavyChain 333310975, 18617, 26259, 33901, 41543, 49185, 56827 anti-HIV-1_HeavyChain3334 10976, 18618, 26260, 33902, 41544, 49186, 56828anti-HIV-1_HeavyChain 3335 10977, 18619, 26261, 33903, 41545, 49187,56829 anti-HIV-1_HeavyChain 3336 10978, 18620, 26262, 33904, 41546,49188, 56830 anti-HIV-1_HeavyChain 3337 10979, 18621, 26263, 33905,41547, 49189, 56831 anti-HIV-1_HeavyChain 3338 10980, 18622, 26264,33906, 41548, 49190, 56832 anti-HIV-1_HeavyChain 3339 10981, 18623,26265, 33907, 41549, 49191, 56833 anti-HIV-1_HeavyChain 3340 10982,18624, 26266, 33908, 41550, 49192, 56834 anti-HIV-1_HeavyChain 334110983, 18625, 26267, 33909, 41551, 49193, 56835 anti-HIV-1_HeavyChain3342 10984, 18626, 26268, 33910, 41552, 49194, 56836anti-HIV-1_HeavyChain 3343 10985, 18627, 26269, 33911, 41553, 49195,56837 anti-HIV-1_HeavyChain 3344 10986, 18628, 26270, 33912, 41554,49196, 56838 anti-HIV-1_HeavyChain 3345 10987, 18629, 26271, 33913,41555, 49197, 56839 anti-HIV-1_HeavyChain 3346 10988, 18630, 26272,33914, 41556, 49198, 56840 anti-HIV-1_HeavyChain 3347 10989, 18631,26273, 33915, 41557, 49199, 56841 anti-HIV-1_HeavyChain 3348 10990,18632, 26274, 33916, 41558, 49200, 56842 anti-HIV-1_HeavyChain 334910991, 18633, 26275, 33917, 41559, 49201, 56843 anti-HIV-1_HeavyChain3350 10992, 18634, 26276, 33918, 41560, 49202, 56844anti-HIV-1_HeavyChain 3351 10993, 18635, 26277, 33919, 41561, 49203,56845 anti-HIV-1_HeavyChain 3352 10994, 18636, 26278, 33920, 41562,49204, 56846 anti-HIV-1_HeavyChain 3353 10995, 18637, 26279, 33921,41563, 49205, 56847 anti-HIV-1_HeavyChain 3354 10996, 18638, 26280,33922, 41564, 49206, 56848 anti-HIV-1_HeavyChain 3355 10997, 18639,26281, 33923, 41565, 49207, 56849 anti-HIV-1_HeavyChain 3356 10998,18640, 26282, 33924, 41566, 49208, 56850 anti-HIV-1_HeavyChain 335710999, 18641, 26283, 33925, 41567, 49209, 56851 anti-HIV-1_HeavyChain3358 11000, 18642, 26284, 33926, 41568, 49210, 56852anti-HIV-1_HeavyChain 3359 11001, 18643, 26285, 33927, 41569, 49211,56853 anti-HIV-1_HeavyChain 3360 11002, 18644, 26286, 33928, 41570,49212, 56854 anti-HIV-1_HeavyChain 3361 11003, 18645, 26287, 33929,41571, 49213, 56855 anti-HIV-1_HeavyChain 3362 11004, 18646, 26288,33930, 41572, 49214, 56856 anti-HIV-1_HeavyChain 3363 11005, 18647,26289, 33931, 41573, 49215, 56857 anti-HIV-1_HeavyChain 3364 11006,18648, 26290, 33932, 41574, 49216, 56858 anti-HIV-1_HeavyChain 336511007, 18649, 26291, 33933, 41575, 49217, 56859 anti-HIV-1_HeavyChain3366 11008, 18650, 26292, 33934, 41576, 49218, 56860anti-HIV-1_HeavyChain 3367 11009, 18651, 26293, 33935, 41577, 49219,56861 anti-HIV-1_HeavyChain 3368 11010, 18652, 26294, 33936, 41578,49220, 56862 anti-HIV-1_HeavyChain 3369 11011, 18653, 26295, 33937,41579, 49221, 56863 anti-HIV-1_HeavyChain 3370 11012, 18654, 26296,33938, 41580, 49222, 56864 anti-HIV-1_HeavyChain 3371 11013, 18655,26297, 33939, 41581, 49223, 56865 anti-HIV-1_HeavyChain 3372 11014,18656, 26298, 33940, 41582, 49224, 56866 anti-HIV-1_HeavyChain 337311015, 18657, 26299, 33941, 41583, 49225, 56867 anti-HIV-1_HeavyChain3374 11016, 18658, 26300, 33942, 41584, 49226, 56868anti-HIV-1_HeavyChain 3375 11017, 18659, 26301, 33943, 41585, 49227,56869 anti-HIV-1_HeavyChain 3376 11018, 18660, 26302, 33944, 41586,49228, 56870 anti-HIV-1_HeavyChain 3377 11019, 18661, 26303, 33945,41587, 49229, 56871 anti-HIV-1_HeavyChain 3378 11020, 18662, 26304,33946, 41588, 49230, 56872 anti-HIV-1_HeavyChain 3379 11021, 18663,26305, 33947, 41589, 49231, 56873 anti-HIV-1_HeavyChain 3380 11022,18664, 26306, 33948, 41590, 49232, 56874 anti-HIV-1_HeavyChain 338111023, 18665, 26307, 33949, 41591, 49233, 56875 anti-HIV-1_HeavyChain3382 11024, 18666, 26308, 33950, 41592, 49234, 56876anti-HIV-1_HeavyChain 3383 11025, 18667, 26309, 33951, 41593, 49235,56877 anti-HIV-1_HeavyChain 3384 11026, 18668, 26310, 33952, 41594,49236, 56878 anti-HIV-1_HeavyChain 3385 11027, 18669, 26311, 33953,41595, 49237, 56879 anti-HIV-1_HeavyChain 3386 11028, 18670, 26312,33954, 41596, 49238, 56880 anti-HIV-1_HeavyChain 3387 11029, 18671,26313, 33955, 41597, 49239, 56881 anti-HIV-1_HeavyChain 3388 11030,18672, 26314, 33956, 41598, 49240, 56882 anti-HIV-1_HeavyChain 338911031, 18673, 26315, 33957, 41599, 49241, 56883 anti-HIV-1_HeavyChain3390 11032, 18674, 26316, 33958, 41600, 49242, 56884anti-HIV-1_HeavyChain 3391 11033, 18675, 26317, 33959, 41601, 49243,56885 anti-HIV-1_HeavyChain 3392 11034, 18676, 26318, 33960, 41602,49244, 56886 anti-HIV-1_HeavyChain 3393 11035, 18677, 26319, 33961,41603, 49245, 56887 anti-HIV-1_HeavyChain 3394 11036, 18678, 26320,33962, 41604, 49246, 56888 anti-HIV-1_HeavyChain 3395 11037, 18679,26321, 33963, 41605, 49247, 56889 anti-HIV-1_HeavyChain 3396 11038,18680, 26322, 33964, 41606, 49248, 56890 anti-HIV-1_HeavyChain 339711039, 18681, 26323, 33965, 41607, 49249, 56891 anti-HIV-1_HeavyChain3398 11040, 18682, 26324, 33966, 41608, 49250, 56892anti-HIV-1_HeavyChain 3399 11041, 18683, 26325, 33967, 41609, 49251,56893 anti-HIV-1_HeavyChain 3400 11042, 18684, 26326, 33968, 41610,49252, 56894 anti-HIV-1_HeavyChain 3401 11043, 18685, 26327, 33969,41611, 49253, 56895 anti-HIV-1_HeavyChain 3402 11044, 18686, 26328,33970, 41612, 49254, 56896 anti-HIV-1_HeavyChain 3403 11045, 18687,26329, 33971, 41613, 49255, 56897 anti-HIV-1_HeavyChain 3404 11046,18688, 26330, 33972, 41614, 49256, 56898 anti-HIV-1_HeavyChain 340511047, 18689, 26331, 33973, 41615, 49257, 56899 anti-HIV-1_HeavyChain3406 11048, 18690, 26332, 33974, 41616, 49258, 56900anti-HIV-1_HeavyChain 3407 11049, 18691, 26333, 33975, 41617, 49259,56901 anti-HIV-1_HeavyChain 3408 11050, 18692, 26334, 33976, 41618,49260, 56902 anti-HIV-1_HeavyChain 3409 11051, 18693, 26335, 33977,41619, 49261, 56903 anti-HIV-1_HeavyChain 3410 11052, 18694, 26336,33978, 41620, 49262, 56904 anti-HIV-1_HeavyChain 3411 11053, 18695,26337, 33979, 41621, 49263, 56905 anti-HIV-1_HeavyChain 3412 11054,18696, 26338, 33980, 41622, 49264, 56906 anti-HIV-1_HeavyChain 341311055, 18697, 26339, 33981, 41623, 49265, 56907 anti-HIV-1_HeavyChain3414 11056, 18698, 26340, 33982, 41624, 49266, 56908anti-HIV-1_HeavyChain 3415 11057, 18699, 26341, 33983, 41625, 49267,56909 anti-HIV-1_HeavyChain 3416 11058, 18700, 26342, 33984, 41626,49268, 56910 anti-HIV-1_HeavyChain 3417 11059, 18701, 26343, 33985,41627, 49269, 56911 anti-HIV-1_HeavyChain 3418 11060, 18702, 26344,33986, 41628, 49270, 56912 anti-HIV-1_HeavyChain 3419 11061, 18703,26345, 33987, 41629, 49271, 56913 anti-HIV-1_HeavyChain 3420 11062,18704, 26346, 33988, 41630, 49272, 56914 anti-HIV-1_HeavyChain 342111063, 18705, 26347, 33989, 41631, 49273, 56915 anti-HIV-1_HeavyChain3422 11064, 18706, 26348, 33990, 41632, 49274, 56916anti-HIV-1_HeavyChain 3423 11065, 18707, 26349, 33991, 41633, 49275,56917 anti-HIV-1_HeavyChain 3424 11066, 18708, 26350, 33992, 41634,49276, 56918 anti-HIV-1_HeavyChain 3425 11067, 18709, 26351, 33993,41635, 49277, 56919 anti-HIV-1_HeavyChain 3426 11068, 18710, 26352,33994, 41636, 49278, 56920 anti-HIV-1_HeavyChain 3427 11069, 18711,26353, 33995, 41637, 49279, 56921 anti-HIV-1_HeavyChain 3428 11070,18712, 26354, 33996, 41638, 49280, 56922 anti-HIV-1_HeavyChain 342911071, 18713, 26355, 33997, 41639, 49281, 56923 anti-HIV-1_HeavyChain3430 11072, 18714, 26356, 33998, 41640, 49282, 56924anti-HIV-1_HeavyChain 3431 11073, 18715, 26357, 33999, 41641, 49283,56925 anti-HIV-1_HeavyChain 3432 11074, 18716, 26358, 34000, 41642,49284, 56926 anti-HIV-1_HeavyChain 3433 11075, 18717, 26359, 34001,41643, 49285, 56927 anti-HIV-1_HeavyChain 3434 11076, 18718, 26360,34002, 41644, 49286, 56928 anti-HIV-1_HeavyChain 3435 11077, 18719,26361, 34003, 41645, 49287, 56929 anti-HIV-1_HeavyChain 3436 11078,18720, 26362, 34004, 41646, 49288, 56930 anti-HIV-1_HeavyChain 343711079, 18721, 26363, 34005, 41647, 49289, 56931 anti-HIV-1_HeavyChain3438 11080, 18722, 26364, 34006, 41648, 49290, 56932anti-HIV-1_HeavyChain 3439 11081, 18723, 26365, 34007, 41649, 49291,56933 anti-HIV-1_HeavyChain 3440 11082, 18724, 26366, 34008, 41650,49292, 56934 anti-HIV-1_HeavyChain 3441 11083, 18725, 26367, 34009,41651, 49293, 56935 anti-HIV-1_HeavyChain 3442 11084, 18726, 26368,34010, 41652, 49294, 56936 anti-HIV-1_HeavyChain 3443 11085, 18727,26369, 34011, 41653, 49295, 56937 anti-HIV-1_HeavyChain 3444 11086,18728, 26370, 34012, 41654, 49296, 56938 anti-HIV-1_HeavyChain 344511087, 18729, 26371, 34013, 41655, 49297, 56939 anti-HIV-1_HeavyChain3446 11088, 18730, 26372, 34014, 41656, 49298, 56940anti-HIV-1_HeavyChain 3447 11089, 18731, 26373, 34015, 41657, 49299,56941 anti-HIV-1_HeavyChain 3448 11090, 18732, 26374, 34016, 41658,49300, 56942 anti-HIV-1_HeavyChain 3449 11091, 18733, 26375, 34017,41659, 49301, 56943 anti-HIV-1_HeavyChain 3450 11092, 18734, 26376,34018, 41660, 49302, 56944 anti-HIV-1_HeavyChain 3451 11093, 18735,26377, 34019, 41661, 49303, 56945 anti-HIV-1_HeavyChain 3452 11094,18736, 26378, 34020, 41662, 49304, 56946 anti-HIV-1_HeavyChain 345311095, 18737, 26379, 34021, 41663, 49305, 56947 anti-HIV-1_HeavyChain3454 11096, 18738, 26380, 34022, 41664, 49306, 56948anti-HIV-1_HeavyChain 3455 11097, 18739, 26381, 34023, 41665, 49307,56949 anti-HIV-1_HeavyChain 3456 11098, 18740, 26382, 34024, 41666,49308, 56950 anti-HIV-1_HeavyChain 3457 11099, 18741, 26383, 34025,41667, 49309, 56951 anti-HIV-1_HeavyChain 3458 11100, 18742, 26384,34026, 41668, 49310, 56952 anti-HIV-1_HeavyChain 3459 11101, 18743,26385, 34027, 41669, 49311, 56953 anti-HIV-1_HeavyChain 3460 11102,18744, 26386, 34028, 41670, 49312, 56954 anti-HIV-1_HeavyChain 346111103, 18745, 26387, 34029, 41671, 49313, 56955 anti-HIV-1_HeavyChain3462 11104, 18746, 26388, 34030, 41672, 49314, 56956anti-HIV-1_HeavyChain 3463 11105, 18747, 26389, 34031, 41673, 49315,56957 anti-HIV-1_HeavyChain 3464 11106, 18748, 26390, 34032, 41674,49316, 56958 anti-HIV-1_HeavyChain 3465 11107, 18749, 26391, 34033,41675, 49317, 56959 anti-HIV-1_HeavyChain 3466 11108, 18750, 26392,34034, 41676, 49318, 56960 anti-HIV-1_HeavyChain 3467 11109, 18751,26393, 34035, 41677, 49319, 56961 anti-HIV-1_HeavyChain 3468 11110,18752, 26394, 34036, 41678, 49320, 56962 anti-HIV-1_HeavyChain 346911111, 18753, 26395, 34037, 41679, 49321, 56963 anti-HIV-1_HeavyChain3470 11112, 18754, 26396, 34038, 41680, 49322, 56964anti-HIV-1_HeavyChain 3471 11113, 18755, 26397, 34039, 41681, 49323,56965 anti-HIV-1_HeavyChain 3472 11114, 18756, 26398, 34040, 41682,49324, 56966 anti-HIV-1_HeavyChain 3473 11115, 18757, 26399, 34041,41683, 49325, 56967 anti-HIV-1_HeavyChain 3474 11116, 18758, 26400,34042, 41684, 49326, 56968 anti-HIV-1_HeavyChain 3475 11117, 18759,26401, 34043, 41685, 49327, 56969 anti-HIV-1_HeavyChain 3476 11118,18760, 26402, 34044, 41686, 49328, 56970 anti-HIV-1_HeavyChain 347711119, 18761, 26403, 34045, 41687, 49329, 56971 anti-HIV-1_HeavyChain3478 11120, 18762, 26404, 34046, 41688, 49330, 56972anti-HIV-1_HeavyChain 3479 11121, 18763, 26405, 34047, 41689, 49331,56973 anti-HIV-1_HeavyChain 3480 11122, 18764, 26406, 34048, 41690,49332, 56974 anti-HIV-1_HeavyChain 3481 11123, 18765, 26407, 34049,41691, 49333, 56975 anti-HIV-1_HeavyChain 3482 11124, 18766, 26408,34050, 41692, 49334, 56976 anti-HIV-1_HeavyChain 3483 11125, 18767,26409, 34051, 41693, 49335, 56977 anti-HIV-1_HeavyChain 3484 11126,18768, 26410, 34052, 41694, 49336, 56978 anti-HIV-1_HeavyChain 348511127, 18769, 26411, 34053, 41695, 49337, 56979 anti-HIV-1_HeavyChain3486 11128, 18770, 26412, 34054, 41696, 49338, 56980anti-HIV-1_HeavyChain 3487 11129, 18771, 26413, 34055, 41697, 49339,56981 anti-HIV-1_HeavyChain 3488 11130, 18772, 26414, 34056, 41698,49340, 56982 anti-HIV-1_HeavyChain 3489 11131, 18773, 26415, 34057,41699, 49341, 56983 anti-HIV-1_HeavyChain 3490 11132, 18774, 26416,34058, 41700, 49342, 56984 anti-HIV-1_HeavyChain 3491 11133, 18775,26417, 34059, 41701, 49343, 56985 anti-HIV-1_HeavyChain 3492 11134,18776, 26418, 34060, 41702, 49344, 56986 anti-HIV-1_HeavyChain 349311135, 18777, 26419, 34061, 41703, 49345, 56987 anti-HIV-1_HeavyChain3494 11136, 18778, 26420, 34062, 41704, 49346, 56988anti-HIV-1_HeavyChain 3495 11137, 18779, 26421, 34063, 41705, 49347,56989 anti-HIV-1_HeavyChain 3496 11138, 18780, 26422, 34064, 41706,49348, 56990 anti-HIV-1_HeavyChain 3497 11139, 18781, 26423, 34065,41707, 49349, 56991 anti-HIV-1_HeavyChain 3498 11140, 18782, 26424,34066, 41708, 49350, 56992 anti-HIV-1_HeavyChain 3499 11141, 18783,26425, 34067, 41709, 49351, 56993 anti-HIV-1_HeavyChain 3500 11142,18784, 26426, 34068, 41710, 49352, 56994 anti-HIV-1_HeavyChain 350111143, 18785, 26427, 34069, 41711, 49353, 56995 anti-HIV-1_HeavyChain3502 11144, 18786, 26428, 34070, 41712, 49354, 56996anti-HIV-1_HeavyChain 3503 11145, 18787, 26429, 34071, 41713, 49355,56997 anti-HIV-1_HeavyChain 3504 11146, 18788, 26430, 34072, 41714,49356, 56998 anti-HIV-1_HeavyChain 3505 11147, 18789, 26431, 34073,41715, 49357, 56999 anti-HIV-1_HeavyChain 3506 11148, 18790, 26432,34074, 41716, 49358, 57000 anti-HIV-1_HeavyChain 3507 11149, 18791,26433, 34075, 41717, 49359, 57001 anti-HIV-1_HeavyChain 3508 11150,18792, 26434, 34076, 41718, 49360, 57002 anti-HIV-1_HeavyChain 350911151, 18793, 26435, 34077, 41719, 49361, 57003 anti-HIV-1_HeavyChain3510 11152, 18794, 26436, 34078, 41720, 49362, 57004anti-HIV-1_HeavyChain 3511 11153, 18795, 26437, 34079, 41721, 49363,57005 anti-HIV-1_HeavyChain 3512 11154, 18796, 26438, 34080, 41722,49364, 57006 anti-HIV-1_HeavyChain 3513 11155, 18797, 26439, 34081,41723, 49365, 57007 anti-HIV-1_HeavyChain 3514 11156, 18798, 26440,34082, 41724, 49366, 57008 anti-HIV-1_HeavyChain 3515 11157, 18799,26441, 34083, 41725, 49367, 57009 anti-HIV-1_HeavyChain 3516 11158,18800, 26442, 34084, 41726, 49368, 57010 anti-HIV-1_HeavyChain 351711159, 18801, 26443, 34085, 41727, 49369, 57011 anti-HIV-1_HeavyChain3518 11160, 18802, 26444, 34086, 41728, 49370, 57012anti-HIV-1_HeavyChain 3519 11161, 18803, 26445, 34087, 41729, 49371,57013 anti-HIV-1_HeavyChain 3520 11162, 18804, 26446, 34088, 41730,49372, 57014 anti-HIV-1_HeavyChain 3521 11163, 18805, 26447, 34089,41731, 49373, 57015 anti-HIV-1_HeavyChain 3522 11164, 18806, 26448,34090, 41732, 49374, 57016 anti-HIV-1_HeavyChain 3523 11165, 18807,26449, 34091, 41733, 49375, 57017 anti-HIV-1_HeavyChain 3524 11166,18808, 26450, 34092, 41734, 49376, 57018 anti-HIV-1_HeavyChain 352511167, 18809, 26451, 34093, 41735, 49377, 57019 anti-HIV-1_HeavyChain3526 11168, 18810, 26452, 34094, 41736, 49378, 57020anti-HIV-1_HeavyChain 3527 11169, 18811, 26453, 34095, 41737, 49379,57021 anti-HIV-1_HeavyChain 3528 11170, 18812, 26454, 34096, 41738,49380, 57022 anti-HIV-1_HeavyChain 3529 11171, 18813, 26455, 34097,41739, 49381, 57023 anti-HIV-1_HeavyChain 3530 11172, 18814, 26456,34098, 41740, 49382, 57024 anti-HIV-1_HeavyChain 3531 11173, 18815,26457, 34099, 41741, 49383, 57025 anti-HIV-1_HeavyChain 3532 11174,18816, 26458, 34100, 41742, 49384, 57026 anti-HIV-1_HeavyChain 353311175, 18817, 26459, 34101, 41743, 49385, 57027 anti-HIV-1_HeavyChain3534 11176, 18818, 26460, 34102, 41744, 49386, 57028anti-HIV-1_HeavyChain 3535 11177, 18819, 26461, 34103, 41745, 49387,57029 anti-HIV-1_HeavyChain 3536 11178, 18820, 26462, 34104, 41746,49388, 57030 anti-HIV-1_HeavyChain 3537 11179, 18821, 26463, 34105,41747, 49389, 57031 anti-HIV-1_HeavyChain 3538 11180, 18822, 26464,34106, 41748, 49390, 57032 anti-HIV-1_HeavyChain 3539 11181, 18823,26465, 34107, 41749, 49391, 57033 anti-HIV-1_HeavyChain 3540 11182,18824, 26466, 34108, 41750, 49392, 57034 anti-HIV-1_HeavyChain 354111183, 18825, 26467, 34109, 41751, 49393, 57035 anti-HIV-1_HeavyChain3542 11184, 18826, 26468, 34110, 41752, 49394, 57036anti-HIV-1_HeavyChain 3543 11185, 18827, 26469, 34111, 41753, 49395,57037 anti-HIV-1_HeavyChain 3544 11186, 18828, 26470, 34112, 41754,49396, 57038 anti-HIV-1_HeavyChain 3545 11187, 18829, 26471, 34113,41755, 49397, 57039 anti-HIV-1_HeavyChain 3546 11188, 18830, 26472,34114, 41756, 49398, 57040 anti-HIV-1_HeavyChain 3547 11189, 18831,26473, 34115, 41757, 49399, 57041 anti-HIV-1_HeavyChain 3548 11190,18832, 26474, 34116, 41758, 49400, 57042 anti-HIV-1_HeavyChain 354911191, 18833, 26475, 34117, 41759, 49401, 57043 anti-HIV-1_HeavyChain3550 11192, 18834, 26476, 34118, 41760, 49402, 57044anti-HIV-1_HeavyChain 3551 11193, 18835, 26477, 34119, 41761, 49403,57045 anti-HIV-1_HeavyChain 3552 11194, 18836, 26478, 34120, 41762,49404, 57046 anti-HIV-1_HeavyChain 3553 11195, 18837, 26479, 34121,41763, 49405, 57047 anti-HIV-1_HeavyChain 3554 11196, 18838, 26480,34122, 41764, 49406, 57048 anti-HIV-1_HeavyChain 3555 11197, 18839,26481, 34123, 41765, 49407, 57049 anti-HIV-1_HeavyChain 3556 11198,18840, 26482, 34124, 41766, 49408, 57050 anti-HIV-1_HeavyChain 355711199, 18841, 26483, 34125, 41767, 49409, 57051 anti-HIV-1_HeavyChain3558 11200, 18842, 26484, 34126, 41768, 49410, 57052anti-HIV-1_HeavyChain 3559 11201, 18843, 26485, 34127, 41769, 49411,57053 anti-HIV-1_HeavyChain 3560 11202, 18844, 26486, 34128, 41770,49412, 57054 anti-HIV-1_HeavyChain 3561 11203, 18845, 26487, 34129,41771, 49413, 57055 anti-HIV-1_HeavyChain 3562 11204, 18846, 26488,34130, 41772, 49414, 57056 anti-HIV-1_HeavyChain 3563 11205, 18847,26489, 34131, 41773, 49415, 57057 anti-HIV-1_HeavyChain 3564 11206,18848, 26490, 34132, 41774, 49416, 57058 anti-HIV-1_HeavyChain 356511207, 18849, 26491, 34133, 41775, 49417, 57059 anti-HIV-1_HeavyChain3566 11208, 18850, 26492, 34134, 41776, 49418, 57060anti-HIV-1_HeavyChain 3567 11209, 18851, 26493, 34135, 41777, 49419,57061 anti-HIV-1_HeavyChain 3568 11210, 18852, 26494, 34136, 41778,49420, 57062 anti-HIV-1_HeavyChain 3569 11211, 18853, 26495, 34137,41779, 49421, 57063 anti-HIV-1_HeavyChain 3570 11212, 18854, 26496,34138, 41780, 49422, 57064 anti-HIV-1_HeavyChain 3571 11213, 18855,26497, 34139, 41781, 49423, 57065 anti-HIV-1_HeavyChain 3572 11214,18856, 26498, 34140, 41782, 49424, 57066 anti-HIV-1_HeavyChain 357311215, 18857, 26499, 34141, 41783, 49425, 57067 anti-HIV-1_HeavyChain3574 11216, 18858, 26500, 34142, 41784, 49426, 57068anti-HIV-1_HeavyChain 3575 11217, 18859, 26501, 34143, 41785, 49427,57069 anti-HIV-1_HeavyChain 3576 11218, 18860, 26502, 34144, 41786,49428, 57070 anti-HIV-1_HeavyChain 3577 11219, 18861, 26503, 34145,41787, 49429, 57071 anti-HIV-1_HeavyChain 3578 11220, 18862, 26504,34146, 41788, 49430, 57072 anti-HIV-1_HeavyChain 3579 11221, 18863,26505, 34147, 41789, 49431, 57073 anti-HIV-1_HeavyChain 3580 11222,18864, 26506, 34148, 41790, 49432, 57074 anti-HIV-1_HeavyChain 358111223, 18865, 26507, 34149, 41791, 49433, 57075 anti-HIV-1_HeavyChain3582 11224, 18866, 26508, 34150, 41792, 49434, 57076anti-HIV-1_HeavyChain 3583 11225, 18867, 26509, 34151, 41793, 49435,57077 anti-HIV-1_HeavyChain 3584 11226, 18868, 26510, 34152, 41794,49436, 57078 anti-HIV-1_HeavyChain 3585 11227, 18869, 26511, 34153,41795, 49437, 57079 anti-HIV-1_HeavyChain 3586 11228, 18870, 26512,34154, 41796, 49438, 57080 anti-HIV-1_HeavyChain 3587 11229, 18871,26513, 34155, 41797, 49439, 57081 anti-HIV-1_HeavyChain 3588 11230,18872, 26514, 34156, 41798, 49440, 57082 anti-HIV-1_HeavyChain 358911231, 18873, 26515, 34157, 41799, 49441, 57083 anti-HIV-1_HeavyChain3590 11232, 18874, 26516, 34158, 41800, 49442, 57084anti-HIV-1_HeavyChain 3591 11233, 18875, 26517, 34159, 41801, 49443,57085 anti-HIV-1_HeavyChain 3592 11234, 18876, 26518, 34160, 41802,49444, 57086 anti-HIV-1_HeavyChain 3593 11235, 18877, 26519, 34161,41803, 49445, 57087 anti-HIV-1_HeavyChain 3594 11236, 18878, 26520,34162, 41804, 49446, 57088 anti-HIV-1_HeavyChain 3595 11237, 18879,26521, 34163, 41805, 49447, 57089 anti-HIV-1_HeavyChain 3596 11238,18880, 26522, 34164, 41806, 49448, 57090 anti-HIV-1_HeavyChain 359711239, 18881, 26523, 34165, 41807, 49449, 57091 anti-HIV-1_HeavyChain3598 11240, 18882, 26524, 34166, 41808, 49450, 57092anti-HIV-1_HeavyChain 3599 11241, 18883, 26525, 34167, 41809, 49451,57093 anti-HIV-1_HeavyChain 3600 11242, 18884, 26526, 34168, 41810,49452, 57094 anti-HIV-1_HeavyChain 3601 11243, 18885, 26527, 34169,41811, 49453, 57095 anti-HIV-1_HeavyChain 3602 11244, 18886, 26528,34170, 41812, 49454, 57096 anti-HIV-1_HeavyChain 3603 11245, 18887,26529, 34171, 41813, 49455, 57097 anti-HIV-1_HeavyChain 3604 11246,18888, 26530, 34172, 41814, 49456, 57098 anti-HIV-1_HeavyChain 360511247, 18889, 26531, 34173, 41815, 49457, 57099 anti-HIV-1_HeavyChain3606 11248, 18890, 26532, 34174, 41816, 49458, 57100anti-HIV-1_HeavyChain 3607 11249, 18891, 26533, 34175, 41817, 49459,57101 anti-HIV-1_HeavyChain 3608 11250, 18892, 26534, 34176, 41818,49460, 57102 anti-HIV-1_HeavyChain 3609 11251, 18893, 26535, 34177,41819, 49461, 57103 anti-HIV-1_HeavyChain 3610 11252, 18894, 26536,34178, 41820, 49462, 57104 anti-HIV-1_HeavyChain 3611 11253, 18895,26537, 34179, 41821, 49463, 57105 anti-HIV-1_HeavyChain 3612 11254,18896, 26538, 34180, 41822, 49464, 57106 anti-HIV-1_HeavyChain 361311255, 18897, 26539, 34181, 41823, 49465, 57107 anti-HIV-1_HeavyChain3614 11256, 18898, 26540, 34182, 41824, 49466, 57108anti-HIV-1_HeavyChain 3615 11257, 18899, 26541, 34183, 41825, 49467,57109 anti-HIV-1_HeavyChain 3616 11258, 18900, 26542, 34184, 41826,49468, 57110 anti-HIV-1_HeavyChain 3617 11259, 18901, 26543, 34185,41827, 49469, 57111 anti-HIV-1_HeavyChain 3618 11260, 18902, 26544,34186, 41828, 49470, 57112 anti-HIV-1_HeavyChain 3619 11261, 18903,26545, 34187, 41829, 49471, 57113 anti-HIV-1_HeavyChain 3620 11262,18904, 26546, 34188, 41830, 49472, 57114 anti-HIV-1_HeavyChain 362111263, 18905, 26547, 34189, 41831, 49473, 57115 anti-HIV-1_HeavyChain3622 11264, 18906, 26548, 34190, 41832, 49474, 57116anti-HIV-1_HeavyChain 3623 11265, 18907, 26549, 34191, 41833, 49475,57117 anti-HIV-1_HeavyChain 3624 11266, 18908, 26550, 34192, 41834,49476, 57118 anti-HIV-1_HeavyChain 3625 11267, 18909, 26551, 34193,41835, 49477, 57119 anti-HIV-1_HeavyChain 3626 11268, 18910, 26552,34194, 41836, 49478, 57120 anti-HIV-1_HeavyChain 3627 11269, 18911,26553, 34195, 41837, 49479, 57121 anti-HIV-1_HeavyChain 3628 11270,18912, 26554, 34196, 41838, 49480, 57122 anti-HIV-1_HeavyChain 362911271, 18913, 26555, 34197, 41839, 49481, 57123 anti-HIV-1_HeavyChain3630 11272, 18914, 26556, 34198, 41840, 49482, 57124anti-HIV-1_HeavyChain 3631 11273, 18915, 26557, 34199, 41841, 49483,57125 anti-HIV-1_HeavyChain 3632 11274, 18916, 26558, 34200, 41842,49484, 57126 anti-HIV-1_HeavyChain 3633 11275, 18917, 26559, 34201,41843, 49485, 57127 anti-HIV-1_HeavyChain 3634 11276, 18918, 26560,34202, 41844, 49486, 57128 anti-HIV-1_HeavyChain 3635 11277, 18919,26561, 34203, 41845, 49487, 57129 anti-HIV-1_HeavyChain 3636 11278,18920, 26562, 34204, 41846, 49488, 57130 anti-HIV-1_HeavyChain 363711279, 18921, 26563, 34205, 41847, 49489, 57131 anti-HIV-1_HeavyChain3638 11280, 18922, 26564, 34206, 41848, 49490, 57132anti-HIV-1_HeavyChain 3639 11281, 18923, 26565, 34207, 41849, 49491,57133 anti-HIV-1_HeavyChain 3640 11282, 18924, 26566, 34208, 41850,49492, 57134 anti-HIV-1_HeavyChain 3641 11283, 18925, 26567, 34209,41851, 49493, 57135 anti-HIV-1_HeavyChain 3642 11284, 18926, 26568,34210, 41852, 49494, 57136 anti-HIV-1_HeavyChain 3643 11285, 18927,26569, 34211, 41853, 49495, 57137 anti-HIV-1_HeavyChain 3644 11286,18928, 26570, 34212, 41854, 49496, 57138 anti-HIV-1_HeavyChain 364511287, 18929, 26571, 34213, 41855, 49497, 57139 anti-HIV-1_HeavyChain3646 11288, 18930, 26572, 34214, 41856, 49498, 57140anti-HIV-1_HeavyChain 3647 11289, 18931, 26573, 34215, 41857, 49499,57141 anti-HIV-1_HeavyChain 3648 11290, 18932, 26574, 34216, 41858,49500, 57142 anti-HIV-1_HeavyChain 3649 11291, 18933, 26575, 34217,41859, 49501, 57143 anti-HIV-1_HeavyChain 3650 11292, 18934, 26576,34218, 41860, 49502, 57144 anti-HIV-1_HeavyChain 3651 11293, 18935,26577, 34219, 41861, 49503, 57145 anti-HIV-1_HeavyChain 3652 11294,18936, 26578, 34220, 41862, 49504, 57146 anti-HIV-1_HeavyChain 365311295, 18937, 26579, 34221, 41863, 49505, 57147 anti-HIV-1_HeavyChain3654 11296, 18938, 26580, 34222, 41864, 49506, 57148anti-HIV-1_HeavyChain 3655 11297, 18939, 26581, 34223, 41865, 49507,57149 anti-HIV-1_HeavyChain 3656 11298, 18940, 26582, 34224, 41866,49508, 57150 anti-HIV-1_HeavyChain 3657 11299, 18941, 26583, 34225,41867, 49509, 57151 anti-HIV-1_HeavyChain 3658 11300, 18942, 26584,34226, 41868, 49510, 57152 anti-HIV-1_HeavyChain 3659 11301, 18943,26585, 34227, 41869, 49511, 57153 anti-HIV-1_HeavyChain 3660 11302,18944, 26586, 34228, 41870, 49512, 57154 anti-HIV-1_HeavyChain 366111303, 18945, 26587, 34229, 41871, 49513, 57155 anti-HIV-1_HeavyChain3662 11304, 18946, 26588, 34230, 41872, 49514, 57156anti-HIV-1_HeavyChain 3663 11305, 18947, 26589, 34231, 41873, 49515,57157 anti-HIV-1_HeavyChain 3664 11306, 18948, 26590, 34232, 41874,49516, 57158 anti-HIV-1_HeavyChain 3665 11307, 18949, 26591, 34233,41875, 49517, 57159 anti-HIV-1_HeavyChain 3666 11308, 18950, 26592,34234, 41876, 49518, 57160 anti-HIV-1_HeavyChain 3667 11309, 18951,26593, 34235, 41877, 49519, 57161 anti-HIV-1_HeavyChain 3668 11310,18952, 26594, 34236, 41878, 49520, 57162 anti-HIV-1_HeavyChain 366911311, 18953, 26595, 34237, 41879, 49521, 57163 anti-HIV-1_HeavyChain3670 11312, 18954, 26596, 34238, 41880, 49522, 57164anti-HIV-1_HeavyChain 3671 11313, 18955, 26597, 34239, 41881, 49523,57165 anti-HIV-1_HeavyChain 3672 11314, 18956, 26598, 34240, 41882,49524, 57166 anti-HIV-1_HeavyChain 3673 11315, 18957, 26599, 34241,41883, 49525, 57167 anti-HIV-1_HeavyChain 3674 11316, 18958, 26600,34242, 41884, 49526, 57168 anti-HIV-1_HeavyChain 3675 11317, 18959,26601, 34243, 41885, 49527, 57169 anti-HIV-1_HeavyChain 3676 11318,18960, 26602, 34244, 41886, 49528, 57170 anti-HIV-1_HeavyChain 367711319, 18961, 26603, 34245, 41887, 49529, 57171 anti-HIV-1_HeavyChain3678 11320, 18962, 26604, 34246, 41888, 49530, 57172anti-HIV-1_HeavyChain 3679 11321, 18963, 26605, 34247, 41889, 49531,57173 anti-HIV-1_HeavyChain 3680 11322, 18964, 26606, 34248, 41890,49532, 57174 anti-HIV-1_HeavyChain 3681 11323, 18965, 26607, 34249,41891, 49533, 57175 anti-HIV-1_HeavyChain 3682 11324, 18966, 26608,34250, 41892, 49534, 57176 anti-HIV-1_HeavyChain 3683 11325, 18967,26609, 34251, 41893, 49535, 57177 anti-HIV-1_HeavyChain 3684 11326,18968, 26610, 34252, 41894, 49536, 57178 anti-HIV-1_HeavyChain 368511327, 18969, 26611, 34253, 41895, 49537, 57179 anti-HIV-1_HeavyChain3686 11328, 18970, 26612, 34254, 41896, 49538, 57180anti-HIV-1_HeavyChain 3687 11329, 18971, 26613, 34255, 41897, 49539,57181 anti-HIV-1_HeavyChain 3688 11330, 18972, 26614, 34256, 41898,49540, 57182 anti-HIV-1_HeavyChain 3689 11331, 18973, 26615, 34257,41899, 49541, 57183 anti-HIV-1_HeavyChain 3690 11332, 18974, 26616,34258, 41900, 49542, 57184 anti-HIV-1_HeavyChain 3691 11333, 18975,26617, 34259, 41901, 49543, 57185 anti-HIV-1_HeavyChain 3692 11334,18976, 26618, 34260, 41902, 49544, 57186 anti-HIV-1_HeavyChain 369311335, 18977, 26619, 34261, 41903, 49545, 57187 anti-HIV-1_HeavyChain3694 11336, 18978, 26620, 34262, 41904, 49546, 57188anti-HIV-1_HeavyChain 3695 11337, 18979, 26621, 34263, 41905, 49547,57189 anti-HIV-1_HeavyChain 3696 11338, 18980, 26622, 34264, 41906,49548, 57190 anti-HIV-1_HeavyChain 3697 11339, 18981, 26623, 34265,41907, 49549, 57191 anti-HIV-1_HeavyChain 3698 11340, 18982, 26624,34266, 41908, 49550, 57192 anti-HIV-1_HeavyChain 3699 11341, 18983,26625, 34267, 41909, 49551, 57193 anti-HIV-1_HeavyChain 3700 11342,18984, 26626, 34268, 41910, 49552, 57194 anti-HIV-1_HeavyChain 370111343, 18985, 26627, 34269, 41911, 49553, 57195 anti-HIV-1_HeavyChain3702 11344, 18986, 26628, 34270, 41912, 49554, 57196anti-HIV-1_HeavyChain 3703 11345, 18987, 26629, 34271, 41913, 49555,57197 anti-HIV-1_HeavyChain 3704 11346, 18988, 26630, 34272, 41914,49556, 57198 anti-HIV-1_HeavyChain 3705 11347, 18989, 26631, 34273,41915, 49557, 57199 anti-HIV-1_HeavyChain 3706 11348, 18990, 26632,34274, 41916, 49558, 57200 anti-HIV-1_HeavyChain 3707 11349, 18991,26633, 34275, 41917, 49559, 57201 anti-HIV-1_HeavyChain 3708 11350,18992, 26634, 34276, 41918, 49560, 57202 anti-HIV-1_HeavyChain 370911351, 18993, 26635, 34277, 41919, 49561, 57203 anti-HIV-1_HeavyChain3710 11352, 18994, 26636, 34278, 41920, 49562, 57204anti-HIV-1_HeavyChain 3711 11353, 18995, 26637, 34279, 41921, 49563,57205 anti-HIV-1_HeavyChain 3712 11354, 18996, 26638, 34280, 41922,49564, 57206 anti-HIV-1_HeavyChain 3713 11355, 18997, 26639, 34281,41923, 49565, 57207 anti-HIV-1_HeavyChain 3714 11356, 18998, 26640,34282, 41924, 49566, 57208 anti-HIV-1_HeavyChain 3715 11357, 18999,26641, 34283, 41925, 49567, 57209 anti-HIV-1_HeavyChain 3716 11358,19000, 26642, 34284, 41926, 49568, 57210 anti-HIV-1_HeavyChain 371711359, 19001, 26643, 34285, 41927, 49569, 57211 anti-HIV-1_HeavyChain3718 11360, 19002, 26644, 34286, 41928, 49570, 57212anti-HIV-1_HeavyChain 3719 11361, 19003, 26645, 34287, 41929, 49571,57213 anti-HIV-1_HeavyChain 3720 11362, 19004, 26646, 34288, 41930,49572, 57214 anti-HIV-1_HeavyChain 3721 11363, 19005, 26647, 34289,41931, 49573, 57215 anti-HIV-1_HeavyChain 3722 11364, 19006, 26648,34290, 41932, 49574, 57216 anti-HIV-1_HeavyChain 3723 11365, 19007,26649, 34291, 41933, 49575, 57217 anti-HIV-1_HeavyChain 3724 11366,19008, 26650, 34292, 41934, 49576, 57218 anti-HIV-1_HeavyChain 372511367, 19009, 26651, 34293, 41935, 49577, 57219 anti-HIV-1_HeavyChain3726 11368, 19010, 26652, 34294, 41936, 49578, 57220anti-HIV-1_HeavyChain 3727 11369, 19011, 26653, 34295, 41937, 49579,57221 anti-HIV-1_HeavyChain 3728 11370, 19012, 26654, 34296, 41938,49580, 57222 anti-HIV-1_HeavyChain 3729 11371, 19013, 26655, 34297,41939, 49581, 57223 anti-HIV-1_HeavyChain 3730 11372, 19014, 26656,34298, 41940, 49582, 57224 anti-HIV-1_HeavyChain 3731 11373, 19015,26657, 34299, 41941, 49583, 57225 anti-HIV-1_HeavyChain 3732 11374,19016, 26658, 34300, 41942, 49584, 57226 anti-HIV-1_HeavyChain 373311375, 19017, 26659, 34301, 41943, 49585, 57227 anti-HIV-1_HeavyChain3734 11376, 19018, 26660, 34302, 41944, 49586, 57228anti-HIV-1_HeavyChain 3735 11377, 19019, 26661, 34303, 41945, 49587,57229 anti-HIV-1_HeavyChain 3736 11378, 19020, 26662, 34304, 41946,49588, 57230 anti-HIV-1_HeavyChain 3737 11379, 19021, 26663, 34305,41947, 49589, 57231 anti-HIV-1_HeavyChain 3738 11380, 19022, 26664,34306, 41948, 49590, 57232 anti-HIV-1_HeavyChain 3739 11381, 19023,26665, 34307, 41949, 49591, 57233 anti-HIV-1_HeavyChain 3740 11382,19024, 26666, 34308, 41950, 49592, 57234 anti-HIV-1_HeavyChain 374111383, 19025, 26667, 34309, 41951, 49593, 57235 anti-HIV-1_HeavyChain3742 11384, 19026, 26668, 34310, 41952, 49594, 57236anti-HIV-1_HeavyChain 3743 11385, 19027, 26669, 34311, 41953, 49595,57237 anti-HIV-1_HeavyChain 3744 11386, 19028, 26670, 34312, 41954,49596, 57238 anti-HIV-1_HeavyChain 3745 11387, 19029, 26671, 34313,41955, 49597, 57239 anti-HIV-1_HeavyChain 3746 11388, 19030, 26672,34314, 41956, 49598, 57240 anti-HIV-1_HeavyChain 3747 11389, 19031,26673, 34315, 41957, 49599, 57241 anti-HIV-1_HeavyChain 3748 11390,19032, 26674, 34316, 41958, 49600, 57242 anti-HIV-1_HeavyChain 374911391, 19033, 26675, 34317, 41959, 49601, 57243 anti-HIV-1_HeavyChain3750 11392, 19034, 26676, 34318, 41960, 49602, 57244anti-HIV-1_HeavyChain 3751 11393, 19035, 26677, 34319, 41961, 49603,57245 anti-HIV-1_HeavyChain 3752 11394, 19036, 26678, 34320, 41962,49604, 57246 anti-HIV-1_HeavyChain 3753 11395, 19037, 26679, 34321,41963, 49605, 57247 anti-HIV-1_HeavyChain 3754 11396, 19038, 26680,34322, 41964, 49606, 57248 anti-HIV-1_HeavyChain 3755 11397, 19039,26681, 34323, 41965, 49607, 57249 anti-HIV-1_HeavyChain 3756 11398,19040, 26682, 34324, 41966, 49608, 57250 anti-HIV-1_HeavyChain 375711399, 19041, 26683, 34325, 41967, 49609, 57251 anti-HIV-1_HeavyChain3758 11400, 19042, 26684, 34326, 41968, 49610, 57252anti-HIV-1_HeavyChain 3759 11401, 19043, 26685, 34327, 41969, 49611,57253 anti-HIV-1_HeavyChain 3760 11402, 19044, 26686, 34328, 41970,49612, 57254 anti-HIV-1_HeavyChain 3761 11403, 19045, 26687, 34329,41971, 49613, 57255 anti-HIV-1_HeavyChain 3762 11404, 19046, 26688,34330, 41972, 49614, 57256 anti-HIV-1_HeavyChain 3763 11405, 19047,26689, 34331, 41973, 49615, 57257 anti-HIV-1_HeavyChain 3764 11406,19048, 26690, 34332, 41974, 49616, 57258 anti-HIV-1_HeavyChain 376511407, 19049, 26691, 34333, 41975, 49617, 57259 anti-HIV-1_HeavyChain3766 11408, 19050, 26692, 34334, 41976, 49618, 57260anti-HIV-1_HeavyChain 3767 11409, 19051, 26693, 34335, 41977, 49619,57261 anti-HIV-1_HeavyChain 3768 11410, 19052, 26694, 34336, 41978,49620, 57262 anti-HIV-1_HeavyChain 3769 11411, 19053, 26695, 34337,41979, 49621, 57263 anti-HIV-1_HeavyChain 3770 11412, 19054, 26696,34338, 41980, 49622, 57264 anti-HIV-1_HeavyChain 3771 11413, 19055,26697, 34339, 41981, 49623, 57265 anti-HIV-1_HeavyChain 3772 11414,19056, 26698, 34340, 41982, 49624, 57266 anti-HIV-1_HeavyChain 377311415, 19057, 26699, 34341, 41983, 49625, 57267 anti-HIV-1_HeavyChain3774 11416, 19058, 26700, 34342, 41984, 49626, 57268anti-HIV-1_HeavyChain 3775 11417, 19059, 26701, 34343, 41985, 49627,57269 anti-HIV-1_HeavyChain 3776 11418, 19060, 26702, 34344, 41986,49628, 57270 anti-HIV-1_HeavyChain 3777 11419, 19061, 26703, 34345,41987, 49629, 57271 anti-HIV-1_HeavyChain 3778 11420, 19062, 26704,34346, 41988, 49630, 57272 anti-HIV-1_HeavyChain 3779 11421, 19063,26705, 34347, 41989, 49631, 57273 anti-HIV-1_HeavyChain 3780 11422,19064, 26706, 34348, 41990, 49632, 57274 anti-HIV-1_HeavyChain 378111423, 19065, 26707, 34349, 41991, 49633, 57275 anti-HIV-1_HeavyChain3782 11424, 19066, 26708, 34350, 41992, 49634, 57276anti-HIV-1_HeavyChain 3783 11425, 19067, 26709, 34351, 41993, 49635,57277 anti-HIV-1_HeavyChain 3784 11426, 19068, 26710, 34352, 41994,49636, 57278 anti-HIV-1_HeavyChain 3785 11427, 19069, 26711, 34353,41995, 49637, 57279 anti-HIV-1_HeavyChain 3786 11428, 19070, 26712,34354, 41996, 49638, 57280 anti-HIV-1_HeavyChain 3787 11429, 19071,26713, 34355, 41997, 49639, 57281 anti-HIV-1_HeavyChain 3788 11430,19072, 26714, 34356, 41998, 49640, 57282 anti-HIV-1_HeavyChain 378911431, 19073, 26715, 34357, 41999, 49641, 57283 anti-HIV-1_HeavyChain3790 11432, 19074, 26716, 34358, 42000, 49642, 57284anti-HIV-1_HeavyChain 3791 11433, 19075, 26717, 34359, 42001, 49643,57285 anti-HIV-1_HeavyChain 3792 11434, 19076, 26718, 34360, 42002,49644, 57286 anti-HIV-1_HeavyChain 3793 11435, 19077, 26719, 34361,42003, 49645, 57287 anti-HIV-1_HeavyChain 3794 11436, 19078, 26720,34362, 42004, 49646, 57288 anti-HIV-1_HeavyChain 3795 11437, 19079,26721, 34363, 42005, 49647, 57289 anti-HIV-1_HeavyChain 3796 11438,19080, 26722, 34364, 42006, 49648, 57290 anti-HIV-1_HeavyChain 379711439, 19081, 26723, 34365, 42007, 49649, 57291 anti-HIV-1_HeavyChain3798 11440, 19082, 26724, 34366, 42008, 49650, 57292anti-HIV-1_HeavyChain 3799 11441, 19083, 26725, 34367, 42009, 49651,57293 anti-HIV-1_HeavyChain 3800 11442, 19084, 26726, 34368, 42010,49652, 57294 anti-HIV-1_HeavyChain 3801 11443, 19085, 26727, 34369,42011, 49653, 57295 anti-HIV-1_HeavyChain 3802 11444, 19086, 26728,34370, 42012, 49654, 57296 anti-HIV-1_HeavyChain 3803 11445, 19087,26729, 34371, 42013, 49655, 57297 anti-HIV-1_HeavyChain 3804 11446,19088, 26730, 34372, 42014, 49656, 57298 anti-HIV-1_HeavyChain 380511447, 19089, 26731, 34373, 42015, 49657, 57299 anti-HIV-1_HeavyChain3806 11448, 19090, 26732, 34374, 42016, 49658, 57300anti-HIV-1_HeavyChain 3807 11449, 19091, 26733, 34375, 42017, 49659,57301 anti-HIV-1_HeavyChain 3808 11450, 19092, 26734, 34376, 42018,49660, 57302 anti-HIV-1_HeavyChain 3809 11451, 19093, 26735, 34377,42019, 49661, 57303 anti-HIV-1_HeavyChain 3810 11452, 19094, 26736,34378, 42020, 49662, 57304 anti-HIV-1_HeavyChain 3811 11453, 19095,26737, 34379, 42021, 49663, 57305 anti-HIV-1_HeavyChain 3812 11454,19096, 26738, 34380, 42022, 49664, 57306 anti-HIV-1_HeavyChain 381311455, 19097, 26739, 34381, 42023, 49665, 57307 anti-HIV-1_HeavyChain3814 11456, 19098, 26740, 34382, 42024, 49666, 57308anti-HIV-1_HeavyChain 3815 11457, 19099, 26741, 34383, 42025, 49667,57309 anti-HIV-1_HeavyChain 3816 11458, 19100, 26742, 34384, 42026,49668, 57310 anti-HIV-1_HeavyChain 3817 11459, 19101, 26743, 34385,42027, 49669, 57311 anti-HIV-1_HeavyChain 3818 11460, 19102, 26744,34386, 42028, 49670, 57312 anti-HIV-1_HeavyChain 3819 11461, 19103,26745, 34387, 42029, 49671, 57313 anti-HIV-1_HeavyChain 3820 11462,19104, 26746, 34388, 42030, 49672, 57314 anti-HIV-1_HeavyChain 382111463, 19105, 26747, 34389, 42031, 49673, 57315 anti-HIV-1_HeavyChain3822 11464, 19106, 26748, 34390, 42032, 49674, 57316anti-HIV-1_HeavyChain 3823 11465, 19107, 26749, 34391, 42033, 49675,57317 anti-HIV-1_HeavyChain 3824 11466, 19108, 26750, 34392, 42034,49676, 57318 anti-HIV-1_HeavyChain 3825 11467, 19109, 26751, 34393,42035, 49677, 57319 anti-HIV-1_HeavyChain 3826 11468, 19110, 26752,34394, 42036, 49678, 57320 anti-HIV-1_HeavyChain 3827 11469, 19111,26753, 34395, 42037, 49679, 57321 anti-HIV-1_HeavyChain 3828 11470,19112, 26754, 34396, 42038, 49680, 57322 anti-HIV-1_HeavyChain 382911471, 19113, 26755, 34397, 42039, 49681, 57323 anti-HIV-1_HeavyChain3830 11472, 19114, 26756, 34398, 42040, 49682, 57324anti-HIV-1_HeavyChain 3831 11473, 19115, 26757, 34399, 42041, 49683,57325 anti-HIV-1_HeavyChain 3832 11474, 19116, 26758, 34400, 42042,49684, 57326 anti-HIV-1_HeavyChain 3833 11475, 19117, 26759, 34401,42043, 49685, 57327 anti-HIV-1_HeavyChain 3834 11476, 19118, 26760,34402, 42044, 49686, 57328 anti-HIV-1_HeavyChain 3835 11477, 19119,26761, 34403, 42045, 49687, 57329 anti-HIV-1_HeavyChain 3836 11478,19120, 26762, 34404, 42046, 49688, 57330 anti-HIV-1_HeavyChain 383711479, 19121, 26763, 34405, 42047, 49689, 57331 anti-HIV-1_HeavyChain3838 11480, 19122, 26764, 34406, 42048, 49690, 57332anti-HIV-1_HeavyChain 3839 11481, 19123, 26765, 34407, 42049, 49691,57333 anti-HIV-1_HeavyChain 3840 11482, 19124, 26766, 34408, 42050,49692, 57334 anti-HIV-1_HeavyChain 3841 11483, 19125, 26767, 34409,42051, 49693, 57335 anti-HIV-1_HeavyChain 3842 11484, 19126, 26768,34410, 42052, 49694, 57336 anti-HIV-1_HeavyChain 3843 11485, 19127,26769, 34411, 42053, 49695, 57337 anti-HIV-1_HeavyChain 3844 11486,19128, 26770, 34412, 42054, 49696, 57338 anti-HIV-1_HeavyChain 384511487, 19129, 26771, 34413, 42055, 49697, 57339 anti-HIV-1_HeavyChain3846 11488, 19130, 26772, 34414, 42056, 49698, 57340anti-HIV-1_HeavyChain 3847 11489, 19131, 26773, 34415, 42057, 49699,57341 anti-HIV-1_HeavyChain 3848 11490, 19132, 26774, 34416, 42058,49700, 57342 anti-HIV-1_HeavyChain 3849 11491, 19133, 26775, 34417,42059, 49701, 57343 anti-HIV-1_HeavyChain 3850 11492, 19134, 26776,34418, 42060, 49702, 57344 anti-HIV-1_HeavyChain 3851 11493, 19135,26777, 34419, 42061, 49703, 57345 anti-HIV-1_HeavyChain 3852 11494,19136, 26778, 34420, 42062, 49704, 57346 anti-HIV-1_HeavyChain 385311495, 19137, 26779, 34421, 42063, 49705, 57347 anti-HIV-1_HeavyChain3854 11496, 19138, 26780, 34422, 42064, 49706, 57348anti-HIV-1_HeavyChain 3855 11497, 19139, 26781, 34423, 42065, 49707,57349 anti-HIV-1_HeavyChain 3856 11498, 19140, 26782, 34424, 42066,49708, 57350 anti-HIV-1_HeavyChain 3857 11499, 19141, 26783, 34425,42067, 49709, 57351 anti-HIV-1_HeavyChain 3858 11500, 19142, 26784,34426, 42068, 49710, 57352 anti-HIV-1_HeavyChain 3859 11501, 19143,26785, 34427, 42069, 49711, 57353 anti-HIV-1_HeavyChain 3860 11502,19144, 26786, 34428, 42070, 49712, 57354 anti-HIV-1_HeavyChain 386111503, 19145, 26787, 34429, 42071, 49713, 57355 anti-HIV-1_HeavyChain3862 11504, 19146, 26788, 34430, 42072, 49714, 57356anti-HIV-1_HeavyChain 3863 11505, 19147, 26789, 34431, 42073, 49715,57357 anti-HIV-1_HeavyChain 3864 11506, 19148, 26790, 34432, 42074,49716, 57358 anti-HIV-1_HeavyChain 3865 11507, 19149, 26791, 34433,42075, 49717, 57359 anti-HIV-1_HeavyChain 3866 11508, 19150, 26792,34434, 42076, 49718, 57360 anti-HIV-1_HeavyChain 3867 11509, 19151,26793, 34435, 42077, 49719, 57361 anti-HIV-1_HeavyChain 3868 11510,19152, 26794, 34436, 42078, 49720, 57362 anti-HIV-1_HeavyChain 386911511, 19153, 26795, 34437, 42079, 49721, 57363 anti-HIV-1_HeavyChain3870 11512, 19154, 26796, 34438, 42080, 49722, 57364anti-HIV-1_HeavyChain 3871 11513, 19155, 26797, 34439, 42081, 49723,57365 anti-HIV-1_HeavyChain 3872 11514, 19156, 26798, 34440, 42082,49724, 57366 anti-HIV-1_HeavyChain 3873 11515, 19157, 26799, 34441,42083, 49725, 57367 anti-HIV-1_HeavyChain 3874 11516, 19158, 26800,34442, 42084, 49726, 57368 anti-HIV-1_HeavyChain 3875 11517, 19159,26801, 34443, 42085, 49727, 57369 anti-HIV-1_HeavyChain 3876 11518,19160, 26802, 34444, 42086, 49728, 57370 anti-HIV-1_HeavyChain 387711519, 19161, 26803, 34445, 42087, 49729, 57371 anti-HIV-1_HeavyChain3878 11520, 19162, 26804, 34446, 42088, 49730, 57372anti-HIV-1_HeavyChain 3879 11521, 19163, 26805, 34447, 42089, 49731,57373 anti-HIV-1_HeavyChain 3880 11522, 19164, 26806, 34448, 42090,49732, 57374 anti-HIV-1_HeavyChain 3881 11523, 19165, 26807, 34449,42091, 49733, 57375 anti-HIV-1_HeavyChain 3882 11524, 19166, 26808,34450, 42092, 49734, 57376 anti-HIV-1_HeavyChain 3883 11525, 19167,26809, 34451, 42093, 49735, 57377 anti-HIV-1_HeavyChain 3884 11526,19168, 26810, 34452, 42094, 49736, 57378 anti-HIV-1_HeavyChain 388511527, 19169, 26811, 34453, 42095, 49737, 57379 anti-HIV-1_HeavyChain3886 11528, 19170, 26812, 34454, 42096, 49738, 57380anti-HIV-1_HeavyChain 3887 11529, 19171, 26813, 34455, 42097, 49739,57381 anti-HIV-1_HeavyChain 3888 11530, 19172, 26814, 34456, 42098,49740, 57382 anti-HIV-1_HeavyChain 3889 11531, 19173, 26815, 34457,42099, 49741, 57383 anti-HIV-1_HeavyChain 3890 11532, 19174, 26816,34458, 42100, 49742, 57384 anti-HIV-1_HeavyChain 3891 11533, 19175,26817, 34459, 42101, 49743, 57385 anti-HIV-1_HeavyChain 3892 11534,19176, 26818, 34460, 42102, 49744, 57386 anti-HIV-1_HeavyChain 389311535, 19177, 26819, 34461, 42103, 49745, 57387 anti-HIV-1_HeavyChain3894 11536, 19178, 26820, 34462, 42104, 49746, 57388anti-HIV-1_HeavyChain 3895 11537, 19179, 26821, 34463, 42105, 49747,57389 anti-HIV-1_HeavyChain 3896 11538, 19180, 26822, 34464, 42106,49748, 57390 anti-HIV-1_HeavyChain 3897 11539, 19181, 26823, 34465,42107, 49749, 57391 anti-HIV-1_HeavyChain 3898 11540, 19182, 26824,34466, 42108, 49750, 57392 anti-HIV-1_HeavyChain 3899 11541, 19183,26825, 34467, 42109, 49751, 57393 anti-HIV-1_HeavyChain 3900 11542,19184, 26826, 34468, 42110, 49752, 57394 anti-HIV-1_HeavyChain 390111543, 19185, 26827, 34469, 42111, 49753, 57395 anti-HIV-1_HeavyChain3902 11544, 19186, 26828, 34470, 42112, 49754, 57396anti-HIV-1_HeavyChain 3903 11545, 19187, 26829, 34471, 42113, 49755,57397 anti-HIV-1_HeavyChain 3904 11546, 19188, 26830, 34472, 42114,49756, 57398 anti-HIV-1_HeavyChain 3905 11547, 19189, 26831, 34473,42115, 49757, 57399 anti-HIV-1_HeavyChain 3906 11548, 19190, 26832,34474, 42116, 49758, 57400 anti-HIV-1_HeavyChain 3907 11549, 19191,26833, 34475, 42117, 49759, 57401 anti-HIV-1_HeavyChain 3908 11550,19192, 26834, 34476, 42118, 49760, 57402 anti-HIV-1_HeavyChain 390911551, 19193, 26835, 34477, 42119, 49761, 57403 anti-HIV-1_HeavyChain3910 11552, 19194, 26836, 34478, 42120, 49762, 57404anti-HIV-1_HeavyChain 3911 11553, 19195, 26837, 34479, 42121, 49763,57405 anti-HIV-1_HeavyChain 3912 11554, 19196, 26838, 34480, 42122,49764, 57406 anti-HIV-1_HeavyChain 3913 11555, 19197, 26839, 34481,42123, 49765, 57407 anti-HIV-1_HeavyChain 3914 11556, 19198, 26840,34482, 42124, 49766, 57408 anti-HIV-1_HeavyChain 3915 11557, 19199,26841, 34483, 42125, 49767, 57409 anti-HIV-1_HeavyChain 3916 11558,19200, 26842, 34484, 42126, 49768, 57410 anti-HIV-1_HeavyChain 391711559, 19201, 26843, 34485, 42127, 49769, 57411 anti-HIV-1_HeavyChain3918 11560, 19202, 26844, 34486, 42128, 49770, 57412anti-HIV-1_HeavyChain 3919 11561, 19203, 26845, 34487, 42129, 49771,57413 anti-HIV-1_HeavyChain 3920 11562, 19204, 26846, 34488, 42130,49772, 57414 anti-HIV-1_HeavyChain 3921 11563, 19205, 26847, 34489,42131, 49773, 57415 anti-HIV-1_HeavyChain 3922 11564, 19206, 26848,34490, 42132, 49774, 57416 anti-HIV-1_HeavyChain 3923 11565, 19207,26849, 34491, 42133, 49775, 57417 anti-HIV-1_HeavyChain 3924 11566,19208, 26850, 34492, 42134, 49776, 57418 anti-HIV-1_HeavyChain 392511567, 19209, 26851, 34493, 42135, 49777, 57419 anti-HIV-1_HeavyChain3926 11568, 19210, 26852, 34494, 42136, 49778, 57420anti-HIV-1_HeavyChain 3927 11569, 19211, 26853, 34495, 42137, 49779,57421 anti-HIV-1_HeavyChain 3928 11570, 19212, 26854, 34496, 42138,49780, 57422 anti-HIV-1_HeavyChain 3929 11571, 19213, 26855, 34497,42139, 49781, 57423 anti-HIV-1_HeavyChain 3930 11572, 19214, 26856,34498, 42140, 49782, 57424 anti-HIV-1_HeavyChain 3931 11573, 19215,26857, 34499, 42141, 49783, 57425 anti-HIV-1_HeavyChain 3932 11574,19216, 26858, 34500, 42142, 49784, 57426 anti-HIV-1_HeavyChain 393311575, 19217, 26859, 34501, 42143, 49785, 57427 anti-HIV-1_HeavyChain3934 11576, 19218, 26860, 34502, 42144, 49786, 57428anti-HIV-1_HeavyChain 3935 11577, 19219, 26861, 34503, 42145, 49787,57429 anti-HIV-1_HeavyChain 3936 11578, 19220, 26862, 34504, 42146,49788, 57430 anti-HIV-1_HeavyChain 3937 11579, 19221, 26863, 34505,42147, 49789, 57431 anti-HIV-1_HeavyChain 3938 11580, 19222, 26864,34506, 42148, 49790, 57432 anti-HIV-1_HeavyChain 3939 11581, 19223,26865, 34507, 42149, 49791, 57433 anti-HIV-1_HeavyChain 3940 11582,19224, 26866, 34508, 42150, 49792, 57434 anti-HIV-1_HeavyChain 394111583, 19225, 26867, 34509, 42151, 49793, 57435 anti-HIV-1_HeavyChain3942 11584, 19226, 26868, 34510, 42152, 49794, 57436anti-HIV-1_HeavyChain 3943 11585, 19227, 26869, 34511, 42153, 49795,57437 anti-HIV-1_HeavyChain 3944 11586, 19228, 26870, 34512, 42154,49796, 57438 anti-HIV-1_HeavyChain 3945 11587, 19229, 26871, 34513,42155, 49797, 57439 anti-HIV-1_HeavyChain 3946 11588, 19230, 26872,34514, 42156, 49798, 57440 anti-HIV-1_HeavyChain 3947 11589, 19231,26873, 34515, 42157, 49799, 57441 anti-HIV-1_HeavyChain 3948 11590,19232, 26874, 34516, 42158, 49800, 57442 anti-HIV-1_HeavyChain 394911591, 19233, 26875, 34517, 42159, 49801, 57443 anti-HIV-1_HeavyChain3950 11592, 19234, 26876, 34518, 42160, 49802, 57444anti-HIV-1_HeavyChain 3951 11593, 19235, 26877, 34519, 42161, 49803,57445 anti-HIV-1_HeavyChain 3952 11594, 19236, 26878, 34520, 42162,49804, 57446 anti-HIV-1_HeavyChain 3953 11595, 19237, 26879, 34521,42163, 49805, 57447 anti-HIV-1_HeavyChain 3954 11596, 19238, 26880,34522, 42164, 49806, 57448 anti-HIV-1_HeavyChain 3955 11597, 19239,26881, 34523, 42165, 49807, 57449 anti-HIV-1_HeavyChain 3956 11598,19240, 26882, 34524, 42166, 49808, 57450 anti-HIV-1_HeavyChain 395711599, 19241, 26883, 34525, 42167, 49809, 57451 anti-HIV-1_HeavyChain3958 11600, 19242, 26884, 34526, 42168, 49810, 57452anti-HIV-1_HeavyChain 3959 11601, 19243, 26885, 34527, 42169, 49811,57453 anti-HIV-1_HeavyChain 3960 11602, 19244, 26886, 34528, 42170,49812, 57454 anti-HIV-1_HeavyChain 3961 11603, 19245, 26887, 34529,42171, 49813, 57455 anti-HIV-1_HeavyChain 3962 11604, 19246, 26888,34530, 42172, 49814, 57456 anti-HIV-1_HeavyChain 3963 11605, 19247,26889, 34531, 42173, 49815, 57457 anti-HIV-1_HeavyChain 3964 11606,19248, 26890, 34532, 42174, 49816, 57458 anti-HIV-1_HeavyChain 396511607, 19249, 26891, 34533, 42175, 49817, 57459 anti-HIV-1_HeavyChain3966 11608, 19250, 26892, 34534, 42176, 49818, 57460anti-HIV-1_HeavyChain 3967 11609, 19251, 26893, 34535, 42177, 49819,57461 anti-HIV-1_HeavyChain 3968 11610, 19252, 26894, 34536, 42178,49820, 57462 anti-HIV-1_HeavyChain 3969 11611, 19253, 26895, 34537,42179, 49821, 57463 anti-HIV-1_HeavyChain 3970 11612, 19254, 26896,34538, 42180, 49822, 57464 anti-HIV-1_HeavyChain 3971 11613, 19255,26897, 34539, 42181, 49823, 57465 anti-HIV-1_HeavyChain 3972 11614,19256, 26898, 34540, 42182, 49824, 57466 anti-HIV-1_HeavyChain 397311615, 19257, 26899, 34541, 42183, 49825, 57467 anti-HIV-1_HeavyChain3974 11616, 19258, 26900, 34542, 42184, 49826, 57468anti-HIV-1_HeavyChain 3975 11617, 19259, 26901, 34543, 42185, 49827,57469 anti-HIV-1_HeavyChain 3976 11618, 19260, 26902, 34544, 42186,49828, 57470 anti-HIV-1_HeavyChain 3977 11619, 19261, 26903, 34545,42187, 49829, 57471 anti-HIV-1_HeavyChain 3978 11620, 19262, 26904,34546, 42188, 49830, 57472 anti-HIV-1_HeavyChain 3979 11621, 19263,26905, 34547, 42189, 49831, 57473 anti-HIV-1_HeavyChain 3980 11622,19264, 26906, 34548, 42190, 49832, 57474 anti-HIV-1_HeavyChain 398111623, 19265, 26907, 34549, 42191, 49833, 57475 anti-HIV-1_HeavyChain3982 11624, 19266, 26908, 34550, 42192, 49834, 57476anti-HIV-1_HeavyChain 3983 11625, 19267, 26909, 34551, 42193, 49835,57477 anti-HIV-1_HeavyChain 3984 11626, 19268, 26910, 34552, 42194,49836, 57478 anti-HIV-1_HeavyChain 3985 11627, 19269, 26911, 34553,42195, 49837, 57479 anti-HIV-1_HeavyChain 3986 11628, 19270, 26912,34554, 42196, 49838, 57480 anti-HIV-1_HeavyChain 3987 11629, 19271,26913, 34555, 42197, 49839, 57481 anti-HIV-1_HeavyChain 3988 11630,19272, 26914, 34556, 42198, 49840, 57482 anti-HIV-1_HeavyChain 398911631, 19273, 26915, 34557, 42199, 49841, 57483 anti-HIV-1_HeavyChain3990 11632, 19274, 26916, 34558, 42200, 49842, 57484anti-HIV-1_HeavyChain 3991 11633, 19275, 26917, 34559, 42201, 49843,57485 anti-HIV-1_HeavyChain 3992 11634, 19276, 26918, 34560, 42202,49844, 57486 anti-HIV-1_HeavyChain 3993 11635, 19277, 26919, 34561,42203, 49845, 57487 anti-HIV-1_HeavyChain 3994 11636, 19278, 26920,34562, 42204, 49846, 57488 anti-HIV-1_HeavyChain 3995 11637, 19279,26921, 34563, 42205, 49847, 57489 anti-HIV-1_HeavyChain 3996 11638,19280, 26922, 34564, 42206, 49848, 57490 anti-HIV-1_HeavyChain 399711639, 19281, 26923, 34565, 42207, 49849, 57491 anti-HIV-1_HeavyChain3998 11640, 19282, 26924, 34566, 42208, 49850, 57492anti-HIV-1_HeavyChain 3999 11641, 19283, 26925, 34567, 42209, 49851,57493 anti-HIV-1_HeavyChain 4000 11642, 19284, 26926, 34568, 42210,49852, 57494 anti-HIV_5CIN_LightChain 4001 11643, 19285, 26927, 34569,42211, 49853, 57495 anti-HIV_5CIN_HeavyChain 4002 11644, 19286, 26928,34570, 42212, 49854, 57496 anti-HIV_5CIL_HeavyChain 4003 11645, 19287,26929, 34571, 42213, 49855, 57497 anti-HIV_5CIP_A-Chain 4004 11646,19288, 26930, 34572, 42214, 49856, 57498 anti-HIV_5CIP_HeavyChain 400511647, 19289, 26931, 34573, 42215, 49857, 57499 anti-HIV_4JKP_LightChain4006 11648, 19290, 26932, 34574, 42216, 49858, 57500anti-HIV_3TNN_E-Chain 4007 11649, 19291, 26933, 34575, 42217, 49859,57501 anti-HIV_3BQU_B-Chain 4008 11650, 19292, 26934, 34576, 42218,49860, 57502 anti-HIV_3BQU_A-Chain 4009 11651, 19293, 26935, 34577,42219, 49861, 57503 anti-HIV_IgG_VR-Chain 4010 11652, 19294, 26936,34578, 42220, 49862, 57504 anti-HIV_IgG_HeavyChain 4011 11653, 19295,26937, 34579, 42221, 49863, 57505 anti-HIV_4P9M_HeavyChain 4012 11654,19296, 26938, 34580, 42222, 49864, 57506 anti-HIV_4P9M_LightChain 401311655, 19297, 26939, 34581, 42223, 49865, 57507 anti-HIV_4P9H_C-Chain4014 11656, 19298, 26940, 34582, 42224, 49866, 57508anti-HIV_4YBL_A-Chain 4015 11657, 19299, 26941, 34583, 42225, 49867,57509 anti-HIV_4R4N_V-Chain 4016 11658, 19300, 26942, 34584, 42226,49868, 57510 anti-HIV_4JKP_G-Chain 4017 11659, 19301, 26943, 34585,42227, 49869, 57511 anti-HIV_3BQU_D-Chain 4018 11660, 19302, 26944,34586, 42228, 49870, 57512 anti-HIV_3BQU_C-Chain 4019 11661, 19303,26945, 34587, 42229, 49871, 57513 anti-HIV_Ig_LightChain 4020 11662,19304, 26946, 34588, 42230, 49872, 57514 anti-HIV_Ig_HeavyChain 402111663, 19305, 26947, 34589, 42231, 49873, 57515 anti-HIV_4P9H_G-Chain4022 11664, 19306, 26948, 34590, 42232, 49874, 57516 anti-HIV_Chain 402311665, 19307, 26949, 34591, 42233, 49875, 57517 anti-HIV_Chain 402411666, 19308, 26950, 34592, 42234, 49876, 57518 anti-HIV_Chain 402511667, 19309, 26951, 34593, 42235, 49877, 57519 anti-HIV_Chain 402611668, 19310, 26952, 34594, 42236, 49878, 57520 anti-HIV_Chain 402711669, 19311, 26953, 34595, 42237, 49879, 57521 anti-HIV_Chain 402811670, 19312, 26954, 34596, 42238, 49880, 57522 anti-HIV_Chain 402911671, 19313, 26955, 34597, 42239, 49881, 57523 anti-HIV_Chain 403011672, 19314, 26956, 34598, 42240, 49882, 57524 anti-HIV_Chain 403111673, 19315, 26957, 34599, 42241, 49883, 57525 anti-HIV_Chain 403211674, 19316, 26958, 34600, 42242, 49884, 57526 anti-HIV_Chain 403311675, 19317, 26959, 34601, 42243, 49885, 57527 anti-HIV_Chain 403411676, 19318, 26960, 34602, 42244, 49886, 57528 anti-HIV_Chain 403511677, 19319, 26961, 34603, 42245, 49887, 57529 anti-HIV_Chain 403611678, 19320, 26962, 34604, 42246, 49888, 57530 anti-HIV_Chain 403711679, 19321, 26963, 34605, 42247, 49889, 57531 anti-HIV_Chain 403811680, 19322, 26964, 34606, 42248, 49890, 57532 anti-HIV_Chain 403911681, 19323, 26965, 34607, 42249, 49891, 57533 anti-HIV_Chain 404011682, 19324, 26966, 34608, 42250, 49892, 57534 anti-HIV_Chain 404111683, 19325, 26967, 34609, 42251, 49893, 57535 anti-HIV_Chain 404211684, 19326, 26968, 34610, 42252, 49894, 57536 anti-HIV_Chain 404311685, 19327, 26969, 34611, 42253, 49895, 57537 anti-HIV_Chain 404411686, 19328, 26970, 34612, 42254, 49896, 57538 anti-HIV_Chain 404511687, 19329, 26971, 34613, 42255, 49897, 57539 anti-HIV_Chain 404611688, 19330, 26972, 34614, 42256, 49898, 57540 anti-HIV_Chain 404711689, 19331, 26973, 34615, 42257, 49899, 57541 anti-HIV_Chain 404811690, 19332, 26974, 34616, 42258, 49900, 57542 anti-HIV_Chain 404911691, 19333, 26975, 34617, 42259, 49901, 57543 anti-HIV_Chain 405011692, 19334, 26976, 34618, 42260, 49902, 57544 anti-HIV_Chain 405111693, 19335, 26977, 34619, 42261, 49903, 57545 anti-HIV_Chain 405211694, 19336, 26978, 34620, 42262, 49904, 57546 anti-HIV_Chain 405311695, 19337, 26979, 34621, 42263, 49905, 57547 anti-HIV_Chain 405411696, 19338, 26980, 34622, 42264, 49906, 57548 anti-HIV_Chain 405511697, 19339, 26981, 34623, 42265, 49907, 57549 anti-HIV_Chain 405611698, 19340, 26982, 34624, 42266, 49908, 57550 anti-HIV_Chain 405711699, 19341, 26983, 34625, 42267, 49909, 57551 anti-HIV_Chain 405811700, 19342, 26984, 34626, 42268, 49910, 57552 anti-HIV_Chain 405911701, 19343, 26985, 34627, 42269, 49911, 57553 anti-HIV_Chain 406011702, 19344, 26986, 34628, 42270, 49912, 57554 anti-HIV_Chain 406111703, 19345, 26987, 34629, 42271, 49913, 57555 anti-HIV_Chain 406211704, 19346, 26988, 34630, 42272, 49914, 57556 anti-HIV_Chain 406311705, 19347, 26989, 34631, 42273, 49915, 57557 anti-HIV_Chain 406411706, 19348, 26990, 34632, 42274, 49916, 57558 anti-HIV_Chain 406511707, 19349, 26991, 34633, 42275, 49917, 57559 anti-HIV_Chain 406611708, 19350, 26992, 34634, 42276, 49918, 57560 anti-HIV_Chain 406711709, 19351, 26993, 34635, 42277, 49919, 57561 anti-HIV_Chain 406811710, 19352, 26994, 34636, 42278, 49920, 57562 anti-HIV_Chain 406911711, 19353, 26995, 34637, 42279, 49921, 57563 anti-HIV_Chain 407011712, 19354, 26996, 34638, 42280, 49922, 57564 anti-HIV_LightChain 407111713, 19355, 26997, 34639, 42281, 49923, 57565 anti-HIV_LightChain 407211714, 19356, 26998, 34640, 42282, 49924, 57566 anti-HIV_Chain 407311715, 19357, 26999, 34641, 42283, 49925, 57567 anti-HIV_Chain 407411716, 19358, 27000, 34642, 42284, 49926, 57568 anti-HIV_Chain 407511717, 19359, 27001, 34643, 42285, 49927, 57569 anti-HIV_HeavyChain 407611718, 19360, 27002, 34644, 42286, 49928, 57570 anti-HIV_Chain 407711719, 19361, 27003, 34645, 42287, 49929, 57571 anti-HIV_Chain 407811720, 19362, 27004, 34646, 42288, 49930, 57572 anti-HIV_LightChain 407911721, 19363, 27005, 34647, 42289, 49931, 57573 anti-HIV_LightChain 408011722, 19364, 27006, 34648, 42290, 49932, 57574 anti-HIV_Chain 408111723, 19365, 27007, 34649, 42291, 49933, 57575 anti-HIV_Chain 408211724, 19366, 27008, 34650, 42292, 49934, 57576 anti-HIV_Chain 408311725, 19367, 27009, 34651, 42293, 49935, 57577 anti-HIV_Chain 408411726, 19368, 27010, 34652, 42294, 49936, 57578 anti-HIV_Chain 408511727, 19369, 27011, 34653, 42295, 49937, 57579 anti-HIV_Chain 408611728, 19370, 27012, 34654, 42296, 49938, 57580 anti-HIV_Chain 408711729, 19371, 27013, 34655, 42297, 49939, 57581 anti-HIV_Chain 408811730, 19372, 27014, 34656, 42298, 49940, 57582 anti-HIV_Chain 408911731, 19373, 27015, 34657, 42299, 49941, 57583 anti-HIV_Chain 409011732, 19374, 27016, 34658, 42300, 49942, 57584 anti-HIV_Chain 409111733, 19375, 27017, 34659, 42301, 49943, 57585 anti-HIV_Chain 409211734, 19376, 27018, 34660, 42302, 49944, 57586 anti-HIV_Chain 409311735, 19377, 27019, 34661, 42303, 49945, 57587 anti-HIV_Chain 409411736, 19378, 27020, 34662, 42304, 49946, 57588 anti-HIV_Chain 409511737, 19379, 27021, 34663, 42305, 49947, 57589 anti-HIV_Chain 409611738, 19380, 27022, 34664, 42306, 49948, 57590 anti-HIV_Chain 409711739, 19381, 27023, 34665, 42307, 49949, 57591 anti-HIV_Chain 409811740, 19382, 27024, 34666, 42308, 49950, 57592 anti-HIV_Chain 409911741, 19383, 27025, 34667, 42309, 49951, 57593 anti-HIV_Chain 410011742, 19384, 27026, 34668, 42310, 49952, 57594 anti-HIV_Chain 410111743, 19385, 27027, 34669, 42311, 49953, 57595 anti-HIV_Chain 410211744, 19386, 27028, 34670, 42312, 49954, 57596 anti-HIV_Chain 410311745, 19387, 27029, 34671, 42313, 49955, 57597 anti-HIV_Chain 410411746, 19388, 27030, 34672, 42314, 49956, 57598 anti-HIV_Chain 410511747, 19389, 27031, 34673, 42315, 49957, 57599 anti-HIV_Chain 410611748, 19390, 27032, 34674, 42316, 49958, 57600 anti-HIV_Chain 410711749, 19391, 27033, 34675, 42317, 49959, 57601 anti-HIV_Chain 410811750, 19392, 27034, 34676, 42318, 49960, 57602 anti-HIV_Chain 410911751, 19393, 27035, 34677, 42319, 49961, 57603 anti-HIV_Chain 411011752, 19394, 27036, 34678, 42320, 49962, 57604 anti-HIV_Chain 411111753, 19395, 27037, 34679, 42321, 49963, 57605 anti-HIV_Chain 411211754, 19396, 27038, 34680, 42322, 49964, 57606 anti-HIV_LightChain 411311755, 19397, 27039, 34681, 42323, 49965, 57607 anti-HIV_LightChain 411411756, 19398, 27040, 34682, 42324, 49966, 57608 anti-HIV_LightChain 411511757, 19399, 27041, 34683, 42325, 49967, 57609 anti-HIV_LightChain 411611758, 19400, 27042, 34684, 42326, 49968, 57610 anti-HIV_LightChain 411711759, 19401, 27043, 34685, 42327, 49969, 57611 anti-HIV_LightChain 411811760, 19402, 27044, 34686, 42328, 49970, 57612 anti-HIV_LightChain 411911761, 19403, 27045, 34687, 42329, 49971, 57613 anti-HIV_LightChain 412011762, 19404, 27046, 34688, 42330, 49972, 57614 anti-HIV_LightChain 412111763, 19405, 27047, 34689, 42331, 49973, 57615 anti-HIV_LightChain 412211764, 19406, 27048, 34690, 42332, 49974, 57616 anti-HIV_LightChain 412311765, 19407, 27049, 34691, 42333, 49975, 57617 anti-HIV_LightChain 412411766, 19408, 27050, 34692, 42334, 49976, 57618 anti-HIV_LightChain 412511767, 19409, 27051, 34693, 42335, 49977, 57619 anti-HIV_LightChain 412611768, 19410, 27052, 34694, 42336, 49978, 57620 anti-HIV_LightChain 412711769, 19411, 27053, 34695, 42337, 49979, 57621 anti-HIV_Chain 412811770, 19412, 27054, 34696, 42338, 49980, 57622 anti-HIV_Chain 412911771, 19413, 27055, 34697, 42339, 49981, 57623 anti-HIV_Chain 413011772, 19414, 27056, 34698, 42340, 49982, 57624 anti-HIV_Chain 413111773, 19415, 27057, 34699, 42341, 49983, 57625 anti-HIV_Chain 413211774, 19416, 27058, 34700, 42342, 49984, 57626 anti-HIV_Chain 413311775, 19417, 27059, 34701, 42343, 49985, 57627 anti-HIV_Chain 413411776, 19418, 27060, 34702, 42344, 49986, 57628 anti-HIV_Chain 413511777, 19419, 27061, 34703, 42345, 49987, 57629 anti-HIV_Chain 413611778, 19420, 27062, 34704, 42346, 49988, 57630 anti-HIV_HeavyChain 413711779, 19421, 27063, 34705, 42347, 49989, 57631 anti-HIV_Chain 413811780, 19422, 27064, 34706, 42348, 49990, 57632 anti-HIV_Chain 413911781, 19423, 27065, 34707, 42349, 49991, 57633 anti-HIV_Chain 414011782, 19424, 27066, 34708, 42350, 49992, 57634 anti-HIV_Chain 414111783, 19425, 27067, 34709, 42351, 49993, 57635 anti-HIV_Chain 414211784, 19426, 27068, 34710, 42352, 49994, 57636 anti-HIV_Chain 414311785, 19427, 27069, 34711, 42353, 49995, 57637 anti-HIV_Chain 414411786, 19428, 27070, 34712, 42354, 49996, 57638 anti-HIV_Chain 414511787, 19429, 27071, 34713, 42355, 49997, 57639 anti-HIV_Chain 414611788, 19430, 27072, 34714, 42356, 49998, 57640 anti-HIV_Chain 414711789, 19431, 27073, 34715, 42357, 49999, 57641 anti-HIV_Chain 414811790, 19432, 27074, 34716, 42358, 50000, 57642 anti-HIV_Chain 414911791, 19433, 27075, 34717, 42359, 50001, 57643 anti-HIV_Chain 415011792, 19434, 27076, 34718, 42360, 50002, 57644 anti-HIV_Chain 415111793, 19435, 27077, 34719, 42361, 50003, 57645 anti-HIV_Chain 415211794, 19436, 27078, 34720, 42362, 50004, 57646 anti-HIV_Chain 415311795, 19437, 27079, 34721, 42363, 50005, 57647 anti-HIV_Chain 415411796, 19438, 27080, 34722, 42364, 50006, 57648 anti-HIV_Chain 415511797, 19439, 27081, 34723, 42365, 50007, 57649 anti-HIV_Chain 415611798, 19440, 27082, 34724, 42366, 50008, 57650 anti-HIV_Chain 415711799, 19441, 27083, 34725, 42367, 50009, 57651 anti-HIV_HeavyChain 415811800, 19442, 27084, 34726, 42368, 50010, 57652 anti-HIV_HeavyChain 415911801, 19443, 27085, 34727, 42369, 50011, 57653 anti-HIV_Chain 416011802, 19444, 27086, 34728, 42370, 50012, 57654 anti-HIV_Chain 416111803, 19445, 27087, 34729, 42371, 50013, 57655 anti-HIV_Chain 416211804, 19446, 27088, 34730, 42372, 50014, 57656 anti-HIV_Chain 416311805, 19447, 27089, 34731, 42373, 50015, 57657 anti-HIV_Chain 416411806, 19448, 27090, 34732, 42374, 50016, 57658 anti-HIV_Chain 416511807, 19449, 27091, 34733, 42375, 50017, 57659 anti-HIV_Chain 416611808, 19450, 27092, 34734, 42376, 50018, 57660 anti-HIV_Chain 416711809, 19451, 27093, 34735, 42377, 50019, 57661 anti-HIV_Chain 416811810, 19452, 27094, 34736, 42378, 50020, 57662 anti-HIV_Chain 416911811, 19453, 27095, 34737, 42379, 50021, 57663 anti-HIV_Chain 417011812, 19454, 27096, 34738, 42380, 50022, 57664 anti-HIV_Chain 417111813, 19455, 27097, 34739, 42381, 50023, 57665 anti-HIV_Chain 417211814, 19456, 27098, 34740, 42382, 50024, 57666 anti-HIV_Chain 417311815, 19457, 27099, 34741, 42383, 50025, 57667 anti-HIV_Chain 417411816, 19458, 27100, 34742, 42384, 50026, 57668 anti-HIV_Chain 417511817, 19459, 27101, 34743, 42385, 50027, 57669 anti-HIV_Chain 417611818, 19460, 27102, 34744, 42386, 50028, 57670 anti-HIV_Chain 417711819, 19461, 27103, 34745, 42387, 50029, 57671 anti-HIV_Chain 417811820, 19462, 27104, 34746, 42388, 50030, 57672 anti-HIV_Chain 417911821, 19463, 27105, 34747, 42389, 50031, 57673 anti-HIV_Chain 418011822, 19464, 27106, 34748, 42390, 50032, 57674 anti-HIV_Chain 418111823, 19465, 27107, 34749, 42391, 50033, 57675 anti-HIV_Chain 418211824, 19466, 27108, 34750, 42392, 50034, 57676 anti-HIV_Chain 418311825, 19467, 27109, 34751, 42393, 50035, 57677 anti-HIV_Chain 418411826, 19468, 27110, 34752, 42394, 50036, 57678 anti-HIV_Chain 418511827, 19469, 27111, 34753, 42395, 50037, 57679 anti-HIV_Chain 418611828, 19470, 27112, 34754, 42396, 50038, 57680 anti-HIV_Chain 418711829, 19471, 27113, 34755, 42397, 50039, 57681 anti-HIV_Chain 418811830, 19472, 27114, 34756, 42398, 50040, 57682 anti-HIV_Chain 418911831, 19473, 27115, 34757, 42399, 50041, 57683 anti-HIV_Chain 419011832, 19474, 27116, 34758, 42400, 50042, 57684 anti-HIV_Chain 419111833, 19475, 27117, 34759, 42401, 50043, 57685 anti-HIV_Chain 419211834, 19476, 27118, 34760, 42402, 50044, 57686 anti-HIV_Chain 419311835, 19477, 27119, 34761, 42403, 50045, 57687 anti-HIV_Chain 419411836, 19478, 27120, 34762, 42404, 50046, 57688 anti-HIV_Chain 419511837, 19479, 27121, 34763, 42405, 50047, 57689 anti-HIV_Chain 419611838, 19480, 27122, 34764, 42406, 50048, 57690 anti-HIV_Chain 419711839, 19481, 27123, 34765, 42407, 50049, 57691 anti-HIV_Chain 419811840, 19482, 27124, 34766, 42408, 50050, 57692 anti-HIV_Chain 419911841, 19483, 27125, 34767, 42409, 50051, 57693 anti-HIV_Chain 420011842, 19484, 27126, 34768, 42410, 50052, 57694 anti-HIV_Chain 420111843, 19485, 27127, 34769, 42411, 50053, 57695 anti-HIV_Chain 420211844, 19486, 27128, 34770, 42412, 50054, 57696 anti-HIV_Chain 420311845, 19487, 27129, 34771, 42413, 50055, 57697 anti-HIV_Chain 420411846, 19488, 27130, 34772, 42414, 50056, 57698 anti-HIV_Chain 420511847, 19489, 27131, 34773, 42415, 50057, 57699 anti-HIV_HeavyChain 420611848, 19490, 27132, 34774, 42416, 50058, 57700 anti-HIV_Chain 420711849, 19491, 27133, 34775, 42417, 50059, 57701 anti-HIV_Chain 420811850, 19492, 27134, 34776, 42418, 50060, 57702 anti-HIV_Chain 420911851, 19493, 27135, 34777, 42419, 50061, 57703 anti-HIV_Chain 421011852, 19494, 27136, 34778, 42420, 50062, 57704 anti-HIV_Chain 421111853, 19495, 27137, 34779, 42421, 50063, 57705 anti-HIV_Chain 421211854, 19496, 27138, 34780, 42422, 50064, 57706 anti-HIV_Chain 421311855, 19497, 27139, 34781, 42423, 50065, 57707 anti-HIV_Chain 421411856, 19498, 27140, 34782, 42424, 50066, 57708 anti-HIV_Chain 421511857, 19499, 27141, 34783, 42425, 50067, 57709 anti-HIV_Chain 421611858, 19500, 27142, 34784, 42426, 50068, 57710 anti-HIV_Chain 421711859, 19501, 27143, 34785, 42427, 50069, 57711 anti-HIV_Chain 421811860, 19502, 27144, 34786, 42428, 50070, 57712 anti-HIV_Chain 421911861, 19503, 27145, 34787, 42429, 50071, 57713 anti-HIV_Chain 422011862, 19504, 27146, 34788, 42430, 50072, 57714 anti-HIV_Chain 422111863, 19505, 27147, 34789, 42431, 50073, 57715 anti-HIV_Chain 422211864, 19506, 27148, 34790, 42432, 50074, 57716 anti-HIV_Chain 422311865, 19507, 27149, 34791, 42433, 50075, 57717 anti-HIV_Chain 422411866, 19508, 27150, 34792, 42434, 50076, 57718 anti-HIV_Chain 422511867, 19509, 27151, 34793, 42435, 50077, 57719 anti-HIV_Chain 422611868, 19510, 27152, 34794, 42436, 50078, 57720 anti-HIV_Chain 422711869, 19511, 27153, 34795, 42437, 50079, 57721 anti-HIV_Chain 422811870, 19512, 27154, 34796, 42438, 50080, 57722 anti-HIV_Chain 422911871, 19513, 27155, 34797, 42439, 50081, 57723 anti-HIV_Chain 423011872, 19514, 27156, 34798, 42440, 50082, 57724 anti-HIV_Chain 423111873, 19515, 27157, 34799, 42441, 50083, 57725 anti-HIV_Chain 423211874, 19516, 27158, 34800, 42442, 50084, 57726 anti-HIV_Chain 423311875, 19517, 27159, 34801, 42443, 50085, 57727 anti-HIV_Chain 423411876, 19518, 27160, 34802, 42444, 50086, 57728 anti-HIV_Chain 423511877, 19519, 27161, 34803, 42445, 50087, 57729 anti-HIV_Chain 423611878, 19520, 27162, 34804, 42446, 50088, 57730 anti-HIV_Chain 423711879, 19521, 27163, 34805, 42447, 50089, 57731 anti-HIV_Chain 423811880, 19522, 27164, 34806, 42448, 50090, 57732 anti-HIV_Chain 423911881, 19523, 27165, 34807, 42449, 50091, 57733 anti-HIV_Chain 424011882, 19524, 27166, 34808, 42450, 50092, 57734 anti-HIV_Chain 424111883, 19525, 27167, 34809, 42451, 50093, 57735 anti-HIV_Chain 424211884, 19526, 27168, 34810, 42452, 50094, 57736 anti-HIV_Chain 424311885, 19527, 27169, 34811, 42453, 50095, 57737 anti-HIV_Chain 424411886, 19528, 27170, 34812, 42454, 50096, 57738 anti-HIV_Chain 424511887, 19529, 27171, 34813, 42455, 50097, 57739 anti-HIV_Chain 424611888, 19530, 27172, 34814, 42456, 50098, 57740 anti-HIV_Chain 424711889, 19531, 27173, 34815, 42457, 50099, 57741 anti-HIV_Chain 424811890, 19532, 27174, 34816, 42458, 50100, 57742 anti-HIV_Chain 424911891, 19533, 27175, 34817, 42459, 50101, 57743 anti-HIV_Chain 425011892, 19534, 27176, 34818, 42460, 50102, 57744 anti-HIV_Chain 425111893, 19535, 27177, 34819, 42461, 50103, 57745 anti-HIV_Chain 425211894, 19536, 27178, 34820, 42462, 50104, 57746 anti-HIV_Chain 425311895, 19537, 27179, 34821, 42463, 50105, 57747 anti-HIV_Chain 425411896, 19538, 27180, 34822, 42464, 50106, 57748 anti-HIV_Chain 425511897, 19539, 27181, 34823, 42465, 50107, 57749 anti-HIV_Chain 425611898, 19540, 27182, 34824, 42466, 50108, 57750 anti-HIV_Chain 425711899, 19541, 27183, 34825, 42467, 50109, 57751 anti-HIV_Chain 425811900, 19542, 27184, 34826, 42468, 50110, 57752 anti-HIV_Chain 425911901, 19543, 27185, 34827, 42469, 50111, 57753 anti-HIV_Chain 426011902, 19544, 27186, 34828, 42470, 50112, 57754 anti-HIV_Chain 426111903, 19545, 27187, 34829, 42471, 50113, 57755 anti-HIV_Chain 426211904, 19546, 27188, 34830, 42472, 50114, 57756 anti-HIV_Chain 426311905, 19547, 27189, 34831, 42473, 50115, 57757 anti-HIV_Chain 426411906, 19548, 27190, 34832, 42474, 50116, 57758 anti-HIV_Chain 426511907, 19549, 27191, 34833, 42475, 50117, 57759 anti-HIV_Chain 426611908, 19550, 27192, 34834, 42476, 50118, 57760 anti-HIV_Chain 426711909, 19551, 27193, 34835, 42477, 50119, 57761 anti-HIV_Chain 426811910, 19552, 27194, 34836, 42478, 50120, 57762 anti-HIV_Chain 426911911, 19553, 27195, 34837, 42479, 50121, 57763 anti-HIV_Chain 427011912, 19554, 27196, 34838, 42480, 50122, 57764 anti-HIV_Chain 427111913, 19555, 27197, 34839, 42481, 50123, 57765 anti-HIV_Chain 427211914, 19556, 27198, 34840, 42482, 50124, 57766 anti-HIV_Chain 427311915, 19557, 27199, 34841, 42483, 50125, 57767 anti-HIV_Chain 427411916, 19558, 27200, 34842, 42484, 50126, 57768 anti-HIV_Chain 427511917, 19559, 27201, 34843, 42485, 50127, 57769 anti-HIV_Chain 427611918, 19560, 27202, 34844, 42486, 50128, 57770 anti-HIV_Chain 427711919, 19561, 27203, 34845, 42487, 50129, 57771 anti-HIV_Chain 427811920, 19562, 27204, 34846, 42488, 50130, 57772 anti-HIV_Chain 427911921, 19563, 27205, 34847, 42489, 50131, 57773 anti-HIV_Chain 428011922, 19564, 27206, 34848, 42490, 50132, 57774 anti-HIV_Chain 428111923, 19565, 27207, 34849, 42491, 50133, 57775 anti-HIV_Chain 428211924, 19566, 27208, 34850, 42492, 50134, 57776 anti-HIV_Chain 428311925, 19567, 27209, 34851, 42493, 50135, 57777 anti-HIV_Chain 428411926, 19568, 27210, 34852, 42494, 50136, 57778 anti-HIV_Chain 428511927, 19569, 27211, 34853, 42495, 50137, 57779 anti-HIV_Chain 428611928, 19570, 27212, 34854, 42496, 50138, 57780 anti-HIV_Chain 428711929, 19571, 27213, 34855, 42497, 50139, 57781 anti-HIV_Chain 428811930, 19572, 27214, 34856, 42498, 50140, 57782 anti-HIV_Chain 428911931, 19573, 27215, 34857, 42499, 50141, 57783 anti-HIV_Chain 429011932, 19574, 27216, 34858, 42500, 50142, 57784 anti-HIV_Chain 429111933, 19575, 27217, 34859, 42501, 50143, 57785 anti-HIV_Chain 429211934, 19576, 27218, 34860, 42502, 50144, 57786 anti-HIV_Chain 429311935, 19577, 27219, 34861, 42503, 50145, 57787 anti-HIV_Chain 429411936, 19578, 27220, 34862, 42504, 50146, 57788 anti-HIV_Chain 429511937, 19579, 27221, 34863, 42505, 50147, 57789 anti-HIV_Chain 429611938, 19580, 27222, 34864, 42506, 50148, 57790 anti-HIV_Chain 429711939, 19581, 27223, 34865, 42507, 50149, 57791 anti-HIV_Chain 429811940, 19582, 27224, 34866, 42508, 50150, 57792 anti-HIV_Chain 429911941, 19583, 27225, 34867, 42509, 50151, 57793 anti-HIV_Chain 430011942, 19584, 27226, 34868, 42510, 50152, 57794 anti-HIV_Chain 430111943, 19585, 27227, 34869, 42511, 50153, 57795 anti-HIV_Chain 430211944, 19586, 27228, 34870, 42512, 50154, 57796 anti-HIV_Chain 430311945, 19587, 27229, 34871, 42513, 50155, 57797 anti-HIV_Chain 430411946, 19588, 27230, 34872, 42514, 50156, 57798 anti-HIV_Chain 430511947, 19589, 27231, 34873, 42515, 50157, 57799 anti-HIV_Chain 430611948, 19590, 27232, 34874, 42516, 50158, 57800 anti-HIV_Chain 430711949, 19591, 27233, 34875, 42517, 50159, 57801 anti-HIV_Chain 430811950, 19592, 27234, 34876, 42518, 50160, 57802 anti-HIV_Chain 430911951, 19593, 27235, 34877, 42519, 50161, 57803 anti-HIV_Chain 431011952, 19594, 27236, 34878, 42520, 50162, 57804 anti-HIV_Chain 431111953, 19595, 27237, 34879, 42521, 50163, 57805 anti-HIV_Chain 431211954, 19596, 27238, 34880, 42522, 50164, 57806 anti-HIV_Chain 431311955, 19597, 27239, 34881, 42523, 50165, 57807 anti-HIV_Chain 431411956, 19598, 27240, 34882, 42524, 50166, 57808 anti-HIV_Chain 431511957, 19599, 27241, 34883, 42525, 50167, 57809 anti-HIV_Chain 431611958, 19600, 27242, 34884, 42526, 50168, 57810 anti-HIV_Chain 431711959, 19601, 27243, 34885, 42527, 50169, 57811 anti-HIV_Chain 431811960, 19602, 27244, 34886, 42528, 50170, 57812 anti-HIV_Chain 431911961, 19603, 27245, 34887, 42529, 50171, 57813 anti-HIV_Chain 432011962, 19604, 27246, 34888, 42530, 50172, 57814 anti-HIV_Chain 432111963, 19605, 27247, 34889, 42531, 50173, 57815 anti-HIV_Chain 432211964, 19606, 27248, 34890, 42532, 50174, 57816 anti-HIV_Chain 432311965, 19607, 27249, 34891, 42533, 50175, 57817 anti-HIV_Chain 432411966, 19608, 27250, 34892, 42534, 50176, 57818 anti-HIV_Chain 432511967, 19609, 27251, 34893, 42535, 50177, 57819 anti-HIV_Chain 432611968, 19610, 27252, 34894, 42536, 50178, 57820 anti-HIV_Chain 432711969, 19611, 27253, 34895, 42537, 50179, 57821 anti-HIV_Chain 432811970, 19612, 27254, 34896, 42538, 50180, 57822 anti-HIV_Chain 432911971, 19613, 27255, 34897, 42539, 50181, 57823 anti-HIV_Chain 433011972, 19614, 27256, 34898, 42540, 50182, 57824 anti-HIV_Chain 433111973, 19615, 27257, 34899, 42541, 50183, 57825 anti-HIV_Chain 433211974, 19616, 27258, 34900, 42542, 50184, 57826 anti-HIV_Chain 433311975, 19617, 27259, 34901, 42543, 50185, 57827 anti-HIV_Chain 433411976, 19618, 27260, 34902, 42544, 50186, 57828 anti-HIV_Chain 433511977, 19619, 27261, 34903, 42545, 50187, 57829 anti-HIV_Chain 433611978, 19620, 27262, 34904, 42546, 50188, 57830 anti-HIV_Chain 433711979, 19621, 27263, 34905, 42547, 50189, 57831 anti-HIV_Chain 433811980, 19622, 27264, 34906, 42548, 50190, 57832 anti-HIV_Chain 433911981, 19623, 27265, 34907, 42549, 50191, 57833 anti-HIV_Chain 434011982, 19624, 27266, 34908, 42550, 50192, 57834 anti-HIV_Chain 434111983, 19625, 27267, 34909, 42551, 50193, 57835 anti-HIV_Chain 434211984, 19626, 27268, 34910, 42552, 50194, 57836 anti-HIV_Chain 434311985, 19627, 27269, 34911, 42553, 50195, 57837 anti-HIV_Chain 434411986, 19628, 27270, 34912, 42554, 50196, 57838 anti-HIV_Chain 434511987, 19629, 27271, 34913, 42555, 50197, 57839 anti-HIV_Chain 434611988, 19630, 27272, 34914, 42556, 50198, 57840 anti-HIV_Chain 434711989, 19631, 27273, 34915, 42557, 50199, 57841 anti-HIV_Chain 434811990, 19632, 27274, 34916, 42558, 50200, 57842 anti-HIV_Chain 434911991, 19633, 27275, 34917, 42559, 50201, 57843 anti-HIV_Chain 435011992, 19634, 27276, 34918, 42560, 50202, 57844 anti-HIV_Chain 435111993, 19635, 27277, 34919, 42561, 50203, 57845 anti-HIV_Chain 435211994, 19636, 27278, 34920, 42562, 50204, 57846 anti-HIV_Chain 435311995, 19637, 27279, 34921, 42563, 50205, 57847 anti-HIV_Chain 435411996, 19638, 27280, 34922, 42564, 50206, 57848 anti-HIV_Chain 435511997, 19639, 27281, 34923, 42565, 50207, 57849 anti-HIV_Chain 435611998, 19640, 27282, 34924, 42566, 50208, 57850 anti-HIV_Chain 435711999, 19641, 27283, 34925, 42567, 50209, 57851 anti-HIV_Chain 435812000, 19642, 27284, 34926, 42568, 50210, 57852 anti-HIV_Chain 435912001, 19643, 27285, 34927, 42569, 50211, 57853 anti-HIV_Chain 436012002, 19644, 27286, 34928, 42570, 50212, 57854 anti-HIV_Chain 436112003, 19645, 27287, 34929, 42571, 50213, 57855 anti-HIV_Chain 436212004, 19646, 27288, 34930, 42572, 50214, 57856 anti-HIV_Chain 436312005, 19647, 27289, 34931, 42573, 50215, 57857 anti-HIV_Chain 436412006, 19648, 27290, 34932, 42574, 50216, 57858 anti-HIV_Chain 436512007, 19649, 27291, 34933, 42575, 50217, 57859 anti-HIV_Chain 436612008, 19650, 27292, 34934, 42576, 50218, 57860 anti-HIV_Chain 436712009, 19651, 27293, 34935, 42577, 50219, 57861 anti-HIV_Chain 436812010, 19652, 27294, 34936, 42578, 50220, 57862 anti-HIV_Chain 436912011, 19653, 27295, 34937, 42579, 50221, 57863 anti-HIV_Chain 437012012, 19654, 27296, 34938, 42580, 50222, 57864 anti-HIV_Chain 437112013, 19655, 27297, 34939, 42581, 50223, 57865 anti-HIV_Chain 437212014, 19656, 27298, 34940, 42582, 50224, 57866 anti-HIV_Chain 437312015, 19657, 27299, 34941, 42583, 50225, 57867 anti-HIV_Chain 437412016, 19658, 27300, 34942, 42584, 50226, 57868 anti-HIV_Chain 437512017, 19659, 27301, 34943, 42585, 50227, 57869 anti-HIV_Chain 437612018, 19660, 27302, 34944, 42586, 50228, 57870 anti-HIV_Chain 437712019, 19661, 27303, 34945, 42587, 50229, 57871 anti-HIV_Chain 437812020, 19662, 27304, 34946, 42588, 50230, 57872 anti-HIV_Chain 437912021, 19663, 27305, 34947, 42589, 50231, 57873 anti-HIV_Chain 438012022, 19664, 27306, 34948, 42590, 50232, 57874 anti-HIV_Chain 438112023, 19665, 27307, 34949, 42591, 50233, 57875 anti-HIV_Chain 438212024, 19666, 27308, 34950, 42592, 50234, 57876 anti-HIV_Chain 438312025, 19667, 27309, 34951, 42593, 50235, 57877 anti-HIV_Chain 438412026, 19668, 27310, 34952, 42594, 50236, 57878 anti-HIV_Chain 438512027, 19669, 27311, 34953, 42595, 50237, 57879 anti-HIV_Chain 438612028, 19670, 27312, 34954, 42596, 50238, 57880 anti-HIV_Chain 438712029, 19671, 27313, 34955, 42597, 50239, 57881 anti-HIV_Chain 438812030, 19672, 27314, 34956, 42598, 50240, 57882 anti-HIV_Chain 438912031, 19673, 27315, 34957, 42599, 50241, 57883 anti-HIV_Chain 439012032, 19674, 27316, 34958, 42600, 50242, 57884 anti-HIV_Chain 439112033, 19675, 27317, 34959, 42601, 50243, 57885 anti-HIV_Chain 439212034, 19676, 27318, 34960, 42602, 50244, 57886 anti-HIV_Chain 439312035, 19677, 27319, 34961, 42603, 50245, 57887 anti-HIV_Chain 439412036, 19678, 27320, 34962, 42604, 50246, 57888 anti-HIV_Chain 439512037, 19679, 27321, 34963, 42605, 50247, 57889 anti-HIV_Chain 439612038, 19680, 27322, 34964, 42606, 50248, 57890 anti-HIV_Chain 439712039, 19681, 27323, 34965, 42607, 50249, 57891 anti-HIV_Chain 439812040, 19682, 27324, 34966, 42608, 50250, 57892 anti-HIV_Chain 439912041, 19683, 27325, 34967, 42609, 50251, 57893 anti-HIV_Chain 440012042, 19684, 27326, 34968, 42610, 50252, 57894 anti-HIV_Chain 440112043, 19685, 27327, 34969, 42611, 50253, 57895 anti-HIV_Chain 440212044, 19686, 27328, 34970, 42612, 50254, 57896 anti-HIV_Chain 440312045, 19687, 27329, 34971, 42613, 50255, 57897 anti-HIV_Chain 440412046, 19688, 27330, 34972, 42614, 50256, 57898 anti-HIV_Chain 440512047, 19689, 27331, 34973, 42615, 50257, 57899 anti-HIV_Chain 440612048, 19690, 27332, 34974, 42616, 50258, 57900 anti-HIV_Chain 440712049, 19691, 27333, 34975, 42617, 50259, 57901 anti-HIV_Chain 440812050, 19692, 27334, 34976, 42618, 50260, 57902 anti-HIV_Chain 440912051, 19693, 27335, 34977, 42619, 50261, 57903 anti-HIV_Chain 441012052, 19694, 27336, 34978, 42620, 50262, 57904 anti-HIV_Chain 441112053, 19695, 27337, 34979, 42621, 50263, 57905 anti-HIV_Chain 441212054, 19696, 27338, 34980, 42622, 50264, 57906 anti-HIV_Chain 441312055, 19697, 27339, 34981, 42623, 50265, 57907 anti-HIV_Chain 441412056, 19698, 27340, 34982, 42624, 50266, 57908 anti-HIV_Chain 441512057, 19699, 27341, 34983, 42625, 50267, 57909 anti-HIV_Chain 441612058, 19700, 27342, 34984, 42626, 50268, 57910 anti-HIV_Chain 441712059, 19701, 27343, 34985, 42627, 50269, 57911 anti-HIV_Chain 441812060, 19702, 27344, 34986, 42628, 50270, 57912 anti-HIV_Chain 441912061, 19703, 27345, 34987, 42629, 50271, 57913 anti-HIV_Chain 442012062, 19704, 27346, 34988, 42630, 50272, 57914 anti-HIV_Chain 442112063, 19705, 27347, 34989, 42631, 50273, 57915 anti-HIV_Chain 442212064, 19706, 27348, 34990, 42632, 50274, 57916 anti-HIV_Chain 442312065, 19707, 27349, 34991, 42633, 50275, 57917 anti-HIV_Chain 442412066, 19708, 27350, 34992, 42634, 50276, 57918 anti-HIV_Chain 442512067, 19709, 27351, 34993, 42635, 50277, 57919 anti-HIV_Chain 442612068, 19710, 27352, 34994, 42636, 50278, 57920 anti-HIV_Chain 442712069, 19711, 27353, 34995, 42637, 50279, 57921 anti-HIV_Chain 442812070, 19712, 27354, 34996, 42638, 50280, 57922 anti-HIV_Chain 442912071, 19713, 27355, 34997, 42639, 50281, 57923 anti-HIV_Chain 443012072, 19714, 27356, 34998, 42640, 50282, 57924 anti-HIV_Chain 443112073, 19715, 27357, 34999, 42641, 50283, 57925 anti-HIV_Chain 443212074, 19716, 27358, 35000, 42642, 50284, 57926 anti-HIV_Chain 443312075, 19717, 27359, 35001, 42643, 50285, 57927 anti-HIV_Chain 443412076, 19718, 27360, 35002, 42644, 50286, 57928 anti-HIV_Chain 443512077, 19719, 27361, 35003, 42645, 50287, 57929 anti-HIV_Chain 443612078, 19720, 27362, 35004, 42646, 50288, 57930 anti-HIV_Chain 443712079, 19721, 27363, 35005, 42647, 50289, 57931 anti-HIV_Chain 443812080, 19722, 27364, 35006, 42648, 50290, 57932 anti-HIV_Chain 443912081, 19723, 27365, 35007, 42649, 50291, 57933 anti-HIV_Chain 444012082, 19724, 27366, 35008, 42650, 50292, 57934 anti-HIV_Chain 444112083, 19725, 27367, 35009, 42651, 50293, 57935 anti-HIV_Chain 444212084, 19726, 27368, 35010, 42652, 50294, 57936 anti-HIV_Chain 444312085, 19727, 27369, 35011, 42653, 50295, 57937 anti-HIV_Chain 444412086, 19728, 27370, 35012, 42654, 50296, 57938 anti-HIV_Chain 444512087, 19729, 27371, 35013, 42655, 50297, 57939 anti-HIV_Chain 444612088, 19730, 27372, 35014, 42656, 50298, 57940 anti-HIV_Chain 444712089, 19731, 27373, 35015, 42657, 50299, 57941 anti-HIV_Chain 444812090, 19732, 27374, 35016, 42658, 50300, 57942 anti-HIV_Chain 444912091, 19733, 27375, 35017, 42659, 50301, 57943 anti-HIV_Chain 445012092, 19734, 27376, 35018, 42660, 50302, 57944 anti-HIV_Chain 445112093, 19735, 27377, 35019, 42661, 50303, 57945 anti-HIV_Chain 445212094, 19736, 27378, 35020, 42662, 50304, 57946 anti-HIV_Chain 445312095, 19737, 27379, 35021, 42663, 50305, 57947 anti-HIV_Chain 445412096, 19738, 27380, 35022, 42664, 50306, 57948 anti-HIV_Chain 445512097, 19739, 27381, 35023, 42665, 50307, 57949 anti-HIV_Chain 445612098, 19740, 27382, 35024, 42666, 50308, 57950 anti-HIV_Chain 445712099, 19741, 27383, 35025, 42667, 50309, 57951 anti-HIV_Chain 445812100, 19742, 27384, 35026, 42668, 50310, 57952 anti-HIV_Chain 445912101, 19743, 27385, 35027, 42669, 50311, 57953 anti-HIV_Chain 446012102, 19744, 27386, 35028, 42670, 50312, 57954 anti-HIV_Chain 446112103, 19745, 27387, 35029, 42671, 50313, 57955 anti-HIV_Chain 446212104, 19746, 27388, 35030, 42672, 50314, 57956 anti-HIV_Chain 446312105, 19747, 27389, 35031, 42673, 50315, 57957 anti-HIV_Chain 446412106, 19748, 27390, 35032, 42674, 50316, 57958 anti-HIV_Chain 446512107, 19749, 27391, 35033, 42675, 50317, 57959 anti-HIV_Chain 446612108, 19750, 27392, 35034, 42676, 50318, 57960 anti-HIV_Chain 446712109, 19751, 27393, 35035, 42677, 50319, 57961 anti-HIV_Chain 446812110, 19752, 27394, 35036, 42678, 50320, 57962 anti-HIV_Chain 446912111, 19753, 27395, 35037, 42679, 50321, 57963 anti-HIV_Chain 447012112, 19754, 27396, 35038, 42680, 50322, 57964 anti-HIV_Chain 447112113, 19755, 27397, 35039, 42681, 50323, 57965 anti-HIV_LightChain 447212114, 19756, 27398, 35040, 42682, 50324, 57966 anti-HIV_Chain 447312115, 19757, 27399, 35041, 42683, 50325, 57967 anti-HIV_Chain 447412116, 19758, 27400, 35042, 42684, 50326, 57968 anti-HIV_Chain 447512117, 19759, 27401, 35043, 42685, 50327, 57969 anti-HIV_Chain 447612118, 19760, 27402, 35044, 42686, 50328, 57970 anti-HIV_Chain 447712119, 19761, 27403, 35045, 42687, 50329, 57971 anti-HIV_Chain 447812120, 19762, 27404, 35046, 42688, 50330, 57972 anti-HIV_Chain 447912121, 19763, 27405, 35047, 42689, 50331, 57973 anti-HIV_Chain 448012122, 19764, 27406, 35048, 42690, 50332, 57974 anti-HIV_Chain 448112123, 19765, 27407, 35049, 42691, 50333, 57975 anti-HIV_Chain 448212124, 19766, 27408, 35050, 42692, 50334, 57976 anti-HIV_Chain 448312125, 19767, 27409, 35051, 42693, 50335, 57977 anti-HIV_Chain 448412126, 19768, 27410, 35052, 42694, 50336, 57978 anti-HIV_Chain 448512127, 19769, 27411, 35053, 42695, 50337, 57979 anti-HIV_Chain 448612128, 19770, 27412, 35054, 42696, 50338, 57980 anti-HIV_Chain 448712129, 19771, 27413, 35055, 42697, 50339, 57981 anti-HIV_Chain 448812130, 19772, 27414, 35056, 42698, 50340, 57982 anti-HIV_Chain 448912131, 19773, 27415, 35057, 42699, 50341, 57983 anti-HIV_Chain 449012132, 19774, 27416, 35058, 42700, 50342, 57984 anti-HIV_Chain 449112133, 19775, 27417, 35059, 42701, 50343, 57985 anti-HIV_Chain 449212134, 19776, 27418, 35060, 42702, 50344, 57986 anti-HIV_Chain 449312135, 19777, 27419, 35061, 42703, 50345, 57987 anti-HIV_Chain 449412136, 19778, 27420, 35062, 42704, 50346, 57988 anti-HIV_Chain 449512137, 19779, 27421, 35063, 42705, 50347, 57989 anti-HIV_Chain 449612138, 19780, 27422, 35064, 42706, 50348, 57990 anti-HIV_Chain 449712139, 19781, 27423, 35065, 42707, 50349, 57991 anti-HIV_Chain 449812140, 19782, 27424, 35066, 42708, 50350, 57992 anti-HIV_Chain 449912141, 19783, 27425, 35067, 42709, 50351, 57993 anti-HIV_Chain 450012142, 19784, 27426, 35068, 42710, 50352, 57994 anti-HIV_Chain 450112143, 19785, 27427, 35069, 42711, 50353, 57995 anti-HIV_Chain 450212144, 19786, 27428, 35070, 42712, 50354, 57996 anti-HIV_Chain 450312145, 19787, 27429, 35071, 42713, 50355, 57997 anti-HIV_Chain 450412146, 19788, 27430, 35072, 42714, 50356, 57998 anti-HIV_Chain 450512147, 19789, 27431, 35073, 42715, 50357, 57999 anti-HIV_Chain 450612148, 19790, 27432, 35074, 42716, 50358, 58000 anti-HIV_Chain 450712149, 19791, 27433, 35075, 42717, 50359, 58001 anti-HIV_Chain 450812150, 19792, 27434, 35076, 42718, 50360, 58002 anti-HIV_Chain 450912151, 19793, 27435, 35077, 42719, 50361, 58003 anti-HIV_Chain 451012152, 19794, 27436, 35078, 42720, 50362, 58004 anti-HIV_Chain 451112153, 19795, 27437, 35079, 42721, 50363, 58005 anti-HIV_Chain 451212154, 19796, 27438, 35080, 42722, 50364, 58006 anti-HIV_Chain 451312155, 19797, 27439, 35081, 42723, 50365, 58007 anti-HIV_Chain 451412156, 19798, 27440, 35082, 42724, 50366, 58008 anti-HIV_Chain 451512157, 19799, 27441, 35083, 42725, 50367, 58009 anti-HIV_Chain 451612158, 19800, 27442, 35084, 42726, 50368, 58010 anti-HIV_Chain 451712159, 19801, 27443, 35085, 42727, 50369, 58011 anti-HIV_Chain 451812160, 19802, 27444, 35086, 42728, 50370, 58012 anti-HIV_Chain 451912161, 19803, 27445, 35087, 42729, 50371, 58013 anti-HIV_Chain 452012162, 19804, 27446, 35088, 42730, 50372, 58014 anti-HIV_Chain 452112163, 19805, 27447, 35089, 42731, 50373, 58015 anti-HIV_Chain 452212164, 19806, 27448, 35090, 42732, 50374, 58016 anti-HIV_Chain 452312165, 19807, 27449, 35091, 42733, 50375, 58017 anti-HIV_Chain 452412166, 19808, 27450, 35092, 42734, 50376, 58018 anti-HIV_Chain 452512167, 19809, 27451, 35093, 42735, 50377, 58019 anti-HIV_Chain 452612168, 19810, 27452, 35094, 42736, 50378, 58020 anti-HIV_Chain 452712169, 19811, 27453, 35095, 42737, 50379, 58021 anti-HIV_Chain 452812170, 19812, 27454, 35096, 42738, 50380, 58022 anti-HIV_Chain 452912171, 19813, 27455, 35097, 42739, 50381, 58023 anti-HIV_Chain 453012172, 19814, 27456, 35098, 42740, 50382, 58024 anti-HIV_Chain 453112173, 19815, 27457, 35099, 42741, 50383, 58025 anti-HIV_Chain 453212174, 19816, 27458, 35100, 42742, 50384, 58026 anti-HIV_Chain 453312175, 19817, 27459, 35101, 42743, 50385, 58027 anti-HIV_Chain 453412176, 19818, 27460, 35102, 42744, 50386, 58028 anti-HIV_Chain 453512177, 19819, 27461, 35103, 42745, 50387, 58029 anti-HIV_Chain 453612178, 19820, 27462, 35104, 42746, 50388, 58030 anti-HIV_Chain 453712179, 19821, 27463, 35105, 42747, 50389, 58031 anti-HIV_Chain 453812180, 19822, 27464, 35106, 42748, 50390, 58032 anti-HIV_Chain 453912181, 19823, 27465, 35107, 42749, 50391, 58033 anti-HIV_Chain 454012182, 19824, 27466, 35108, 42750, 50392, 58034 anti-HIV_Chain 454112183, 19825, 27467, 35109, 42751, 50393, 58035 anti-HIV_Chain 454212184, 19826, 27468, 35110, 42752, 50394, 58036 anti-HIV_LightChain 454312185, 19827, 27469, 35111, 42753, 50395, 58037 anti-HIV_Chain 454412186, 19828, 27470, 35112, 42754, 50396, 58038 anti-HIV_Chain 454512187, 19829, 27471, 35113, 42755, 50397, 58039 anti-HIV_Chain 454612188, 19830, 27472, 35114, 42756, 50398, 58040 anti-HIV_Chain 454712189, 19831, 27473, 35115, 42757, 50399, 58041 anti-HIV_Chain 454812190, 19832, 27474, 35116, 42758, 50400, 58042 anti-HIV_Chain 454912191, 19833, 27475, 35117, 42759, 50401, 58043 anti-HIV_Chain 455012192, 19834, 27476, 35118, 42760, 50402, 58044 anti-HIV_Chain 455112193, 19835, 27477, 35119, 42761, 50403, 58045 anti-HIV_Chain 455212194, 19836, 27478, 35120, 42762, 50404, 58046 anti-HIV_Chain 455312195, 19837, 27479, 35121, 42763, 50405, 58047 anti-HIV_Chain 455412196, 19838, 27480, 35122, 42764, 50406, 58048 anti-HIV_Chain 455512197, 19839, 27481, 35123, 42765, 50407, 58049 anti-HIV_Chain 455612198, 19840, 27482, 35124, 42766, 50408, 58050 anti-HIV_Chain 455712199, 19841, 27483, 35125, 42767, 50409, 58051 anti-HIV_Chain 455812200, 19842, 27484, 35126, 42768, 50410, 58052 anti-HIV_Chain 455912201, 19843, 27485, 35127, 42769, 50411, 58053 anti-HIV_Chain 456012202, 19844, 27486, 35128, 42770, 50412, 58054 anti-HIV_Chain 456112203, 19845, 27487, 35129, 42771, 50413, 58055 anti-HIV_Chain 456212204, 19846, 27488, 35130, 42772, 50414, 58056 anti-HIV_HeavyChain 456312205, 19847, 27489, 35131, 42773, 50415, 58057 anti-HIV_HeavyChain 456412206, 19848, 27490, 35132, 42774, 50416, 58058 anti-HIV_HeavyChain 456512207, 19849, 27491, 35133, 42775, 50417, 58059 anti-HIV_Chain 456612208, 19850, 27492, 35134, 42776, 50418, 58060 anti-HIV_Chain 456712209, 19851, 27493, 35135, 42777, 50419, 58061 anti-HIV_Chain 456812210, 19852, 27494, 35136, 42778, 50420, 58062 anti-HIV_Chain 456912211, 19853, 27495, 35137, 42779, 50421, 58063 anti-HIV_Chain 457012212, 19854, 27496, 35138, 42780, 50422, 58064 anti-HIV_Chain 457112213, 19855, 27497, 35139, 42781, 50423, 58065 anti-HIV_Chain 457212214, 19856, 27498, 35140, 42782, 50424, 58066 anti-HIV_Chain 457312215, 19857, 27499, 35141, 42783, 50425, 58067 anti-HIV_Chain 457412216, 19858, 27500, 35142, 42784, 50426, 58068 anti-HIV_HeavyChain 457512217, 19859, 27501, 35143, 42785, 50427, 58069 anti-HIV_HeavyChain 457612218, 19860, 27502, 35144, 42786, 50428, 58070 anti-HIV_HeavyChain 457712219, 19861, 27503, 35145, 42787, 50429, 58071 anti-HIV_HeavyChain 457812220, 19862, 27504, 35146, 42788, 50430, 58072 anti-HIV_HeavyChain 457912221, 19863, 27505, 35147, 42789, 50431, 58073 anti-HIV_HeavyChain 458012222, 19864, 27506, 35148, 42790, 50432, 58074 anti-HIV_HeavyChain 458112223, 19865, 27507, 35149, 42791, 50433, 58075 anti-HIV_HeavyChain 458212224, 19866, 27508, 35150, 42792, 50434, 58076 anti-HIV_HeavyChain 458312225, 19867, 27509, 35151, 42793, 50435, 58077 anti-HIV_HeavyChain 458412226, 19868, 27510, 35152, 42794, 50436, 58078 anti-HIV_HeavyChain 458512227, 19869, 27511, 35153, 42795, 50437, 58079 anti-HIV_HeavyChain 458612228, 19870, 27512, 35154, 42796, 50438, 58080 anti-HIV_HeavyChain 458712229, 19871, 27513, 35155, 42797, 50439, 58081 anti-HIV_Chain 458812230, 19872, 27514, 35156, 42798, 50440, 58082 anti-HIV_Chain 458912231, 19873, 27515, 35157, 42799, 50441, 58083 anti-HIV_Chain 459012232, 19874, 27516, 35158, 42800, 50442, 58084 anti-HIV_Chain 459112233, 19875, 27517, 35159, 42801, 50443, 58085 anti-HIV_Chain 459212234, 19876, 27518, 35160, 42802, 50444, 58086 anti-HIV_Chain 459312235, 19877, 27519, 35161, 42803, 50445, 58087 anti-HIV_Chain 459412236, 19878, 27520, 35162, 42804, 50446, 58088 anti-HIV_Chain 459512237, 19879, 27521, 35163, 42805, 50447, 58089 anti-HIV_Chain 459612238, 19880, 27522, 35164, 42806, 50448, 58090 anti-HIV_Chain 459712239, 19881, 27523, 35165, 42807, 50449, 58091 anti-HIV_Chain 459812240, 19882, 27524, 35166, 42808, 50450, 58092 anti-HIV_Chain 459912241, 19883, 27525, 35167, 42809, 50451, 58093 anti-HIV_Chain 460012242, 19884, 27526, 35168, 42810, 50452, 58094 anti-HIV_Chain 460112243, 19885, 27527, 35169, 42811, 50453, 58095 anti-HIV_Chain 460212244, 19886, 27528, 35170, 42812, 50454, 58096 anti-HIV_Chain 460312245, 19887, 27529, 35171, 42813, 50455, 58097 anti-HIV_Chain 460412246, 19888, 27530, 35172, 42814, 50456, 58098 anti-HIV_Chain 460512247, 19889, 27531, 35173, 42815, 50457, 58099 anti-HIV_Chain 460612248, 19890, 27532, 35174, 42816, 50458, 58100 anti-HIV_HeavyChain 460712249, 19891, 27533, 35175, 42817, 50459, 58101 anti-HIV_HeavyChain 460812250, 19892, 27534, 35176, 42818, 50460, 58102 anti-HIV_Chain 460912251, 19893, 27535, 35177, 42819, 50461, 58103 anti-HIV_Chain 461012252, 19894, 27536, 35178, 42820, 50462, 58104 anti-HIV_Chain 461112253, 19895, 27537, 35179, 42821, 50463, 58105 anti-HIV_Chain 461212254, 19896, 27538, 35180, 42822, 50464, 58106 anti-HIV_Chain 461312255, 19897, 27539, 35181, 42823, 50465, 58107 anti-HIV_Chain 461412256, 19898, 27540, 35182, 42824, 50466, 58108 anti-HIV_HeavyChain 461512257, 19899, 27541, 35183, 42825, 50467, 58109 anti-HIV_HeavyChain 461612258, 19900, 27542, 35184, 42826, 50468, 58110 anti-HIV_Chain 461712259, 19901, 27543, 35185, 42827, 50469, 58111 anti-HIV_Chain 461812260, 19902, 27544, 35186, 42828, 50470, 58112 anti-HIV_Chain 461912261, 19903, 27545, 35187, 42829, 50471, 58113 anti-HIV_Chain 462012262, 19904, 27546, 35188, 42830, 50472, 58114 anti-HIV_Chain 462112263, 19905, 27547, 35189, 42831, 50473, 58115 anti-HIV_Chain 462212264, 19906, 27548, 35190, 42832, 50474, 58116 anti-HIV_Chain 462312265, 19907, 27549, 35191, 42833, 50475, 58117 anti-HIV_Chain 462412266, 19908, 27550, 35192, 42834, 50476, 58118 anti-HIV_LightChain 462512267, 19909, 27551, 35193, 42835, 50477, 58119 anti-HIV_Chain 462612268, 19910, 27552, 35194, 42836, 50478, 58120 anti-HIV_Chain 462712269, 19911, 27553, 35195, 42837, 50479, 58121 anti-HIV_SingleChain4628 12270, 19912, 27554, 35196, 42838, 50480, 58122 anti-HIV_LightChain4629 12271, 19913, 27555, 35197, 42839, 50481, 58123 anti-HIV_Chain 463012272, 19914, 27556, 35198, 42840, 50482, 58124 anti-HIV_Chain 463112273, 19915, 27557, 35199, 42841, 50483, 58125 anti-influenza_Fab 463212274, 19916, 27558, 35200, 42842, 50484, 58126 anti-influenza_Fab 463312275, 19917, 27559, 35201, 42843, 50485, 58127 anti-influenza_Fab 463412276, 19918, 27560, 35202, 42844, 50486, 58128 anti-influenza_Fab 463512277, 19919, 27561, 35203, 42845, 50487, 58129 anti-influenza_Fab 463612278, 19920, 27562, 35204, 42846, 50488, 58130 anti-influenza_Fab 463712279, 19921, 27563, 35205, 42847, 50489, 58131 anti-influenza_Fab 463812280, 19922, 27564, 35206, 42848, 50490, 58132 anti-influenza_Apo 463912281, 19923, 27565, 35207, 42849, 50491, 58133 anti-influenza_Apo 464012282, 19924, 27566, 35208, 42850, 50492, 58134anti-influenza-A_kappa_LightChain_V-Region 4641 12283, 19925, 27567,35209, 42851, 50493, 58135 anti-influenza-A_kappa_LightChain_V-Region4642 12284, 19926, 27568, 35210, 42852, 50494, 58136anti-influenza-A_kappa_LightChain_V-Region 4643 12285, 19927, 27569,35211, 42853, 50495, 58137 anti-influenza-A_kappa_LightChain_V-Region4644 12286, 19928, 27570, 35212, 42854, 50496, 58138anti-influenza-A_kappa_LightChain_V-Region 4645 12287, 19929, 27571,35213, 42855, 50497, 58139 anti-influenza-A_kappa_LightChain_V-Region4646 12288, 19930, 27572, 35214, 42856, 50498, 58140anti-influenza-A_HeavyChain_V-Region 4647 12289, 19931, 27573, 35215,42857, 50499, 58141 anti-influenza-A_HeavyChain_V-Region 4648 12290,19932, 27574, 35216, 42858, 50500, 58142anti-influenza-A_HeavyChain_V-Region 4649 12291, 19933, 27575, 35217,42859, 50501, 58143 anti-influenza-A_HeavyChain_V-Region 4650 12292,19934, 27576, 35218, 42860, 50502, 58144anti-influenza-A_HeavyChain_V-Region 4651 12293, 19935, 27577, 35219,42861, 50503, 58145 anti-influenza-A_HeavyChain_V-Region 4652 12294,19936, 27578, 35220, 42862, 50504, 58146anti-influenza-A_HeavyChain_V-Region 4653 12295, 19937, 27579, 35221,42863, 50505, 58147 anti-influenza-A_LightChain_V-Region 4654 12296,19938, 27580, 35222, 42864, 50506, 58148anti-influenza-A_HeavyChain_V-Region 4655 12297, 19939, 27581, 35223,42865, 50507, 58149 anti-influenza_Chain 4656 12298, 19940, 27582,35224, 42866, 50508, 58150 anti-influenza_Chain 4657 12299, 19941,27583, 35225, 42867, 50509, 58151 anti-influenza_Chain 4658 12300,19942, 27584, 35226, 42868, 50510, 58152 anti-influenza_Chain 465912301, 19943, 27585, 35227, 42869, 50511, 58153 anti-influenza_Chain4660 12302, 19944, 27586, 35228, 42870, 50512, 58154anti-influenza_Chain 4661 12303, 19945, 27587, 35229, 42871, 50513,58155 anti-influenza_Chain 4662 12304, 19946, 27588, 35230, 42872,50514, 58156 anti-influenza_Chain 4663 12305, 19947, 27589, 35231,42873, 50515, 58157 anti-influenza_Chain 4664 12306, 19948, 27590,35232, 42874, 50516, 58158 anti-influenza_Chain 4665 12307, 19949,27591, 35233, 42875, 50517, 58159 anti-influenza_Chain 4666 12308,19950, 27592, 35234, 42876, 50518, 58160 anti-influenza_Chain 466712309, 19951, 27593, 35235, 42877, 50519, 58161 anti-influenza_Chain4668 12310, 19952, 27594, 35236, 42878, 50520, 58162anti-influenza_Chain 4669 12311, 19953, 27595, 35237, 42879, 50521,58163 anti-influenza_Chain 4670 12312, 19954, 27596, 35238, 42880,50522, 58164 anti-influenza_Chain 4671 12313, 19955, 27597, 35239,42881, 50523, 58165 anti-influenza_Chain 4672 12314, 19956, 27598,35240, 42882, 50524, 58166 anti-influenza_Chain 4673 12315, 19957,27599, 35241, 42883, 50525, 58167 anti-influenza_Chain 4674 12316,19958, 27600, 35242, 42884, 50526, 58168 anti-influenza_Chain 467512317, 19959, 27601, 35243, 42885, 50527, 58169 anti-influenza_Chain4676 12318, 19960, 27602, 35244, 42886, 50528, 58170anti-influenza_Chain 4677 12319, 19961, 27603, 35245, 42887, 50529,58171 anti-influenza_Chain 4678 12320, 19962, 27604, 35246, 42888,50530, 58172 anti-influenza_Chain 4679 12321, 19963, 27605, 35247,42889, 50531, 58173 anti-influenza_Chain 4680 12322, 19964, 27606,35248, 42890, 50532, 58174 anti-influenza_Chain 4681 12323, 19965,27607, 35249, 42891, 50533, 58175 anti-influenza_Chain 4682 12324,19966, 27608, 35250, 42892, 50534, 58176 anti-influenza_Chain 468312325, 19967, 27609, 35251, 42893, 50535, 58177 anti-influenza_Chain4684 12326, 19968, 27610, 35252, 42894, 50536, 58178anti-influenza_Chain 4685 12327, 19969, 27611, 35253, 42895, 50537,58179 anti-influenza_Chain 4686 12328, 19970, 27612, 35254, 42896,50538, 58180 anti-influenza_Chain 4687 12329, 19971, 27613, 35255,42897, 50539, 58181 anti-influenza_Chain 4688 12330, 19972, 27614,35256, 42898, 50540, 58182 anti-influenza_Chain 4689 12331, 19973,27615, 35257, 42899, 50541, 58183 anti-influenza_Chain 4690 12332,19974, 27616, 35258, 42900, 50542, 58184 anti-influenza_Chain 469112333, 19975, 27617, 35259, 42901, 50543, 58185 anti-influenza_Chain4692 12334, 19976, 27618, 35260, 42902, 50544, 58186anti-influenza_Chain 4693 12335, 19977, 27619, 35261, 42903, 50545,58187 anti-influenza_Chain 4694 12336, 19978, 27620, 35262, 42904,50546, 58188 anti-influenza_Chain 4695 12337, 19979, 27621, 35263,42905, 50547, 58189 anti-influenza_Chain 4696 12338, 19980, 27622,35264, 42906, 50548, 58190 anti-influenza_Chain 4697 12339, 19981,27623, 35265, 42907, 50549, 58191 anti-influenza_Chain 4698 12340,19982, 27624, 35266, 42908, 50550, 58192 anti-influenza_Chain 469912341, 19983, 27625, 35267, 42909, 50551, 58193 anti-influenza_Chain4700 12342, 19984, 27626, 35268, 42910, 50552, 58194anti-influenza_Chain 4701 12343, 19985, 27627, 35269, 42911, 50553,58195 anti-influenza_Chain 4702 12344, 19986, 27628, 35270, 42912,50554, 58196 anti-influenza_Chain 4703 12345, 19987, 27629, 35271,42913, 50555, 58197 anti-influenza_Chain 4704 12346, 19988, 27630,35272, 42914, 50556, 58198 anti-influenza_Chain 4705 12347, 19989,27631, 35273, 42915, 50557, 58199 anti-influenza_Chain 4706 12348,19990, 27632, 35274, 42916, 50558, 58200 anti-influenza_Chain 470712349, 19991, 27633, 35275, 42917, 50559, 58201 anti-influenza_Chain4708 12350, 19992, 27634, 35276, 42918, 50560, 58202anti-influenza_Chain 4709 12351, 19993, 27635, 35277, 42919, 50561,58203 anti-influenza_Chain 4710 12352, 19994, 27636, 35278, 42920,50562, 58204 anti-influenza_Chain 4711 12353, 19995, 27637, 35279,42921, 50563, 58205 anti-influenza_Chain 4712 12354, 19996, 27638,35280, 42922, 50564, 58206 anti-influenza_Chain 4713 12355, 19997,27639, 35281, 42923, 50565, 58207 anti-influenza_Chain 4714 12356,19998, 27640, 35282, 42924, 50566, 58208 anti-influenza_Chain 471512357, 19999, 27641, 35283, 42925, 50567, 58209 anti-influenza_Chain4716 12358, 20000, 27642, 35284, 42926, 50568, 58210anti-influenza_Chain 4717 12359, 20001, 27643, 35285, 42927, 50569,58211 anti-influenza_Chain 4718 12360, 20002, 27644, 35286, 42928,50570, 58212 anti-influenza_Chain 4719 12361, 20003, 27645, 35287,42929, 50571, 58213 anti-influenza_Chain 4720 12362, 20004, 27646,35288, 42930, 50572, 58214 anti-influenza_Chain 4721 12363, 20005,27647, 35289, 42931, 50573, 58215 anti-influenza_Chain 4722 12364,20006, 27648, 35290, 42932, 50574, 58216 anti-influenza_Chain 472312365, 20007, 27649, 35291, 42933, 50575, 58217 anti-influenza_Chain4724 12366, 20008, 27650, 35292, 42934, 50576, 58218anti-influenza_Chain 4725 12367, 20009, 27651, 35293, 42935, 50577,58219 anti-influenza_Chain 4726 12368, 20010, 27652, 35294, 42936,50578, 58220 anti-influenza_Chain 4727 12369, 20011, 27653, 35295,42937, 50579, 58221 anti-influenza_Chain 4728 12370, 20012, 27654,35296, 42938, 50580, 58222 anti-influenza_Chain 4729 12371, 20013,27655, 35297, 42939, 50581, 58223 anti-influenza_Chain 4730 12372,20014, 27656, 35298, 42940, 50582, 58224 anti-influenza_Chain 473112373, 20015, 27657, 35299, 42941, 50583, 58225 anti-influenza_Chain4732 12374, 20016, 27658, 35300, 42942, 50584, 58226anti-influenza_Chain 4733 12375, 20017, 27659, 35301, 42943, 50585,58227 anti-influenza_Chain 4734 12376, 20018, 27660, 35302, 42944,50586, 58228 anti-influenza_Chain 4735 12377, 20019, 27661, 35303,42945, 50587, 58229 anti-influenza_Chain 4736 12378, 20020, 27662,35304, 42946, 50588, 58230 anti-influenza_Chain 4737 12379, 20021,27663, 35305, 42947, 50589, 58231 anti-influenza_Chain 4738 12380,20022, 27664, 35306, 42948, 50590, 58232 anti-influenza_Chain 473912381, 20023, 27665, 35307, 42949, 50591, 58233 anti-influenza_Chain4740 12382, 20024, 27666, 35308, 42950, 50592, 58234anti-influenza_Chain 4741 12383, 20025, 27667, 35309, 42951, 50593,58235 anti-influenza_Chain 4742 12384, 20026, 27668, 35310, 42952,50594, 58236 anti-influenza_Chain 4743 12385, 20027, 27669, 35311,42953, 50595, 58237 anti-influenza_Chain 4744 12386, 20028, 27670,35312, 42954, 50596, 58238 anti-influenza_Chain 4745 12387, 20029,27671, 35313, 42955, 50597, 58239 anti-influenza_Chain 4746 12388,20030, 27672, 35314, 42956, 50598, 58240 anti-influenza_Chain 474712389, 20031, 27673, 35315, 42957, 50599, 58241 anti-influenza_Chain4748 12390, 20032, 27674, 35316, 42958, 50600, 58242anti-influenza_Chain 4749 12391, 20033, 27675, 35317, 42959, 50601,58243 anti-influenza_Chain 4750 12392, 20034, 27676, 35318, 42960,50602, 58244 anti-influenza_Chain 4751 12393, 20035, 27677, 35319,42961, 50603, 58245 anti-influenza_Chain 4752 12394, 20036, 27678,35320, 42962, 50604, 58246 anti-influenza_Chain 4753 12395, 20037,27679, 35321, 42963, 50605, 58247 anti-influenza_Chain 4754 12396,20038, 27680, 35322, 42964, 50606, 58248 anti-influenza_Chain 475512397, 20039, 27681, 35323, 42965, 50607, 58249 anti-influenza_Chain4756 12398, 20040, 27682, 35324, 42966, 50608, 58250anti-influenza_Chain 4757 12399, 20041, 27683, 35325, 42967, 50609,58251 anti-influenza_Chain 4758 12400, 20042, 27684, 35326, 42968,50610, 58252 anti-influenza_Chain 4759 12401, 20043, 27685, 35327,42969, 50611, 58253 anti-influenza_Chain 4760 12402, 20044, 27686,35328, 42970, 50612, 58254 anti-influenza_Chain 4761 12403, 20045,27687, 35329, 42971, 50613, 58255 anti-influenza_Chain 4762 12404,20046, 27688, 35330, 42972, 50614, 58256 anti-influenza_Chain 476312405, 20047, 27689, 35331, 42973, 50615, 58257 anti-influenza_Chain4764 12406, 20048, 27690, 35332, 42974, 50616, 58258anti-influenza_Chain 4765 12407, 20049, 27691, 35333, 42975, 50617,58259 anti-influenza_Chain 4766 12408, 20050, 27692, 35334, 42976,50618, 58260 anti-influenza_Chain 4767 12409, 20051, 27693, 35335,42977, 50619, 58261 anti-influenza_Chain 4768 12410, 20052, 27694,35336, 42978, 50620, 58262 anti-influenza_Chain 4769 12411, 20053,27695, 35337, 42979, 50621, 58263 anti-influenza_Chain 4770 12412,20054, 27696, 35338, 42980, 50622, 58264 anti-influenza_Chain 477112413, 20055, 27697, 35339, 42981, 50623, 58265 anti-influenza_Chain4772 12414, 20056, 27698, 35340, 42982, 50624, 58266anti-influenza_Chain 4773 12415, 20057, 27699, 35341, 42983, 50625,58267 anti-influenza_Chain 4774 12416, 20058, 27700, 35342, 42984,50626, 58268 anti-influenza_Chain 4775 12417, 20059, 27701, 35343,42985, 50627, 58269 anti-influenza_Chain 4776 12418, 20060, 27702,35344, 42986, 50628, 58270 anti-influenza_Chain 4777 12419, 20061,27703, 35345, 42987, 50629, 58271 anti-influenza_Chain 4778 12420,20062, 27704, 35346, 42988, 50630, 58272 anti-influenza_Chain 477912421, 20063, 27705, 35347, 42989, 50631, 58273 anti-influenza_Chain4780 12422, 20064, 27706, 35348, 42990, 50632, 58274anti-influenza_Chain 4781 12423, 20065, 27707, 35349, 42991, 50633,58275 anti-influenza_Chain 4782 12424, 20066, 27708, 35350, 42992,50634, 58276 anti-influenza_Chain 4783 12425, 20067, 27709, 35351,42993, 50635, 58277 anti-influenza_Chain 4784 12426, 20068, 27710,35352, 42994, 50636, 58278 anti-influenza_Chain 4785 12427, 20069,27711, 35353, 42995, 50637, 58279 anti-influenza_Chain 4786 12428,20070, 27712, 35354, 42996, 50638, 58280 anti-influenza_Chain 478712429, 20071, 27713, 35355, 42997, 50639, 58281 anti-influenza_Chain4788 12430, 20072, 27714, 35356, 42998, 50640, 58282anti-influenza_Chain 4789 12431, 20073, 27715, 35357, 42999, 50641,58283 anti-influenza_Chain 4790 12432, 20074, 27716, 35358, 43000,50642, 58284 anti-influenza_Chain 4791 12433, 20075, 27717, 35359,43001, 50643, 58285 anti-influenza_Chain 4792 12434, 20076, 27718,35360, 43002, 50644, 58286 anti-influenza_Chain 4793 12435, 20077,27719, 35361, 43003, 50645, 58287 anti-influenza_Chain 4794 12436,20078, 27720, 35362, 43004, 50646, 58288 anti-influenza_Chain 479512437, 20079, 27721, 35363, 43005, 50647, 58289 anti-influenza_Chain4796 12438, 20080, 27722, 35364, 43006, 50648, 58290anti-influenza_Chain 4797 12439, 20081, 27723, 35365, 43007, 50649,58291 anti-influenza_Chain 4798 12440, 20082, 27724, 35366, 43008,50650, 58292 anti-influenza_Chain 4799 12441, 20083, 27725, 35367,43009, 50651, 58293 anti-influenza_Chain 4800 12442, 20084, 27726,35368, 43010, 50652, 58294 anti-influenza_Chain 4801 12443, 20085,27727, 35369, 43011, 50653, 58295 anti-influenza_Chain 4802 12444,20086, 27728, 35370, 43012, 50654, 58296 anti-influenza_Chain 480312445, 20087, 27729, 35371, 43013, 50655, 58297 anti-influenza_Chain4804 12446, 20088, 27730, 35372, 43014, 50656, 58298anti-influenza_Chain 4805 12447, 20089, 27731, 35373, 43015, 50657,58299 anti-influenza_Chain 4806 12448, 20090, 27732, 35374, 43016,50658, 58300 anti-influenza_Chain 4807 12449, 20091, 27733, 35375,43017, 50659, 58301 anti-influenza_Chain 4808 12450, 20092, 27734,35376, 43018, 50660, 58302 anti-influenza_Chain 4809 12451, 20093,27735, 35377, 43019, 50661, 58303 anti-influenza_Chain 4810 12452,20094, 27736, 35378, 43020, 50662, 58304 anti-influenza_Chain 481112453, 20095, 27737, 35379, 43021, 50663, 58305 anti-influenza_Chain4812 12454, 20096, 27738, 35380, 43022, 50664, 58306anti-influenza_Chain 4813 12455, 20097, 27739, 35381, 43023, 50665,58307 anti-influenza_Chain 4814 12456, 20098, 27740, 35382, 43024,50666, 58308 anti-influenza_Chain 4815 12457, 20099, 27741, 35383,43025, 50667, 58309 anti-influenza_Chain 4816 12458, 20100, 27742,35384, 43026, 50668, 58310 anti-influenza_Chain 4817 12459, 20101,27743, 35385, 43027, 50669, 58311 anti-influenza_Chain 4818 12460,20102, 27744, 35386, 43028, 50670, 58312 anti-influenza_Chain 481912461, 20103, 27745, 35387, 43029, 50671, 58313 anti-influenza_Chain4820 12462, 20104, 27746, 35388, 43030, 50672, 58314anti-influenza_Chain 4821 12463, 20105, 27747, 35389, 43031, 50673,58315 anti-influenza_Chain 4822 12464, 20106, 27748, 35390, 43032,50674, 58316 anti-influenza_Chain 4823 12465, 20107, 27749, 35391,43033, 50675, 58317 anti-influenza_Chain 4824 12466, 20108, 27750,35392, 43034, 50676, 58318 anti-influenza_Chain 4825 12467, 20109,27751, 35393, 43035, 50677, 58319 anti-influenza_Chain 4826 12468,20110, 27752, 35394, 43036, 50678, 58320 anti-influenza_Chain 482712469, 20111, 27753, 35395, 43037, 50679, 58321 anti-influenza_Chain4828 12470, 20112, 27754, 35396, 43038, 50680, 58322anti-influenza_Chain 4829 12471, 20113, 27755, 35397, 43039, 50681,58323 anti-influenza_Chain 4830 12472, 20114, 27756, 35398, 43040,50682, 58324 anti-influenza_Chain 4831 12473, 20115, 27757, 35399,43041, 50683, 58325 anti-influenza_Chain 4832 12474, 20116, 27758,35400, 43042, 50684, 58326 anti-influenza_Chain 4833 12475, 20117,27759, 35401, 43043, 50685, 58327 anti-influenza_Chain 4834 12476,20118, 27760, 35402, 43044, 50686, 58328 anti-influenza_Chain 483512477, 20119, 27761, 35403, 43045, 50687, 58329 anti-influenza_Chain4836 12478, 20120, 27762, 35404, 43046, 50688, 58330anti-influenza_Chain 4837 12479, 20121, 27763, 35405, 43047, 50689,58331 anti-influenza_Chain 4838 12480, 20122, 27764, 35406, 43048,50690, 58332 anti-influenza_Chain 4839 12481, 20123, 27765, 35407,43049, 50691, 58333 anti-influenza_Chain 4840 12482, 20124, 27766,35408, 43050, 50692, 58334 anti-influenza_Chain 4841 12483, 20125,27767, 35409, 43051, 50693, 58335 anti-influenza_Chain 4842 12484,20126, 27768, 35410, 43052, 50694, 58336 anti-influenza_Chain 484312485, 20127, 27769, 35411, 43053, 50695, 58337 anti-influenza_Chain4844 12486, 20128, 27770, 35412, 43054, 50696, 58338anti-influenza_Chain 4845 12487, 20129, 27771, 35413, 43055, 50697,58339 anti-influenza_Chain 4846 12488, 20130, 27772, 35414, 43056,50698, 58340 anti-influenza_Chain 4847 12489, 20131, 27773, 35415,43057, 50699, 58341 anti-influenza_Chain 4848 12490, 20132, 27774,35416, 43058, 50700, 58342 anti-influenza_Chain 4849 12491, 20133,27775, 35417, 43059, 50701, 58343 anti-influenza_Chain 4850 12492,20134, 27776, 35418, 43060, 50702, 58344 anti-influenza_Chain 485112493, 20135, 27777, 35419, 43061, 50703, 58345 anti-influenza_Chain4852 12494, 20136, 27778, 35420, 43062, 50704, 58346anti-influenza_Chain 4853 12495, 20137, 27779, 35421, 43063, 50705,58347 anti-influenza_Chain 4854 12496, 20138, 27780, 35422, 43064,50706, 58348 anti-influenza_Chain 4855 12497, 20139, 27781, 35423,43065, 50707, 58349 anti-influenza_Chain 4856 12498, 20140, 27782,35424, 43066, 50708, 58350 anti-influenza_Chain 4857 12499, 20141,27783, 35425, 43067, 50709, 58351 anti-influenza_Chain 4858 12500,20142, 27784, 35426, 43068, 50710, 58352 anti-influenza_Chain 485912501, 20143, 27785, 35427, 43069, 50711, 58353 anti-influenza_Chain4860 12502, 20144, 27786, 35428, 43070, 50712, 58354anti-influenza_Chain 4861 12503, 20145, 27787, 35429, 43071, 50713,58355 anti-influenza_Chain 4862 12504, 20146, 27788, 35430, 43072,50714, 58356 anti-influenza_Chain 4863 12505, 20147, 27789, 35431,43073, 50715, 58357 anti-influenza_Chain 4864 12506, 20148, 27790,35432, 43074, 50716, 58358 anti-influenza_Chain 4865 12507, 20149,27791, 35433, 43075, 50717, 58359 anti-influenza_Chain 4866 12508,20150, 27792, 35434, 43076, 50718, 58360 anti-influenza_Chain 486712509, 20151, 27793, 35435, 43077, 50719, 58361 anti-influenza_Chain4868 12510, 20152, 27794, 35436, 43078, 50720, 58362anti-influenza_Chain 4869 12511, 20153, 27795, 35437, 43079, 50721,58363 anti-influenza_Chain 4870 12512, 20154, 27796, 35438, 43080,50722, 58364 anti-influenza_Chain 4871 12513, 20155, 27797, 35439,43081, 50723, 58365 anti-influenza_Chain 4872 12514, 20156, 27798,35440, 43082, 50724, 58366 anti-influenza_Chain 4873 12515, 20157,27799, 35441, 43083, 50725, 58367 anti-influenza_Chain 4874 12516,20158, 27800, 35442, 43084, 50726, 58368 anti-influenza_Chain 487512517, 20159, 27801, 35443, 43085, 50727, 58369 anti-influenza_Chain4876 12518, 20160, 27802, 35444, 43086, 50728, 58370anti-influenza_Chain 4877 12519, 20161, 27803, 35445, 43087, 50729,58371 anti-influenza_Chain 4878 12520, 20162, 27804, 35446, 43088,50730, 58372 anti-influenza_Chain 4879 12521, 20163, 27805, 35447,43089, 50731, 58373 anti-influenza_Chain 4880 12522, 20164, 27806,35448, 43090, 50732, 58374 anti-influenza_Chain 4881 12523, 20165,27807, 35449, 43091, 50733, 58375 anti-influenza_Chain 4882 12524,20166, 27808, 35450, 43092, 50734, 58376 anti-influenza_Chain 488312525, 20167, 27809, 35451, 43093, 50735, 58377 anti-influenza_Chain4884 12526, 20168, 27810, 35452, 43094, 50736, 58378anti-influenza_Chain 4885 12527, 20169, 27811, 35453, 43095, 50737,58379 anti-influenza_Chain 4886 12528, 20170, 27812, 35454, 43096,50738, 58380 anti-influenza_Chain 4887 12529, 20171, 27813, 35455,43097, 50739, 58381 anti-influenza_Chain 4888 12530, 20172, 27814,35456, 43098, 50740, 58382 anti-influenza_Chain 4889 12531, 20173,27815, 35457, 43099, 50741, 58383 anti-influenza_Chain 4890 12532,20174, 27816, 35458, 43100, 50742, 58384 anti-influenza_Chain 489112533, 20175, 27817, 35459, 43101, 50743, 58385 anti-influenza_Chain4892 12534, 20176, 27818, 35460, 43102, 50744, 58386anti-influenza_Chain 4893 12535, 20177, 27819, 35461, 43103, 50745,58387 anti-influenza_Chain 4894 12536, 20178, 27820, 35462, 43104,50746, 58388 anti-influenza_Chain 4895 12537, 20179, 27821, 35463,43105, 50747, 58389 anti-influenza_Chain 4896 12538, 20180, 27822,35464, 43106, 50748, 58390 anti-influenza_Chain 4897 12539, 20181,27823, 35465, 43107, 50749, 58391 anti-influenza_Chain 4898 12540,20182, 27824, 35466, 43108, 50750, 58392 anti-influenza_Chain 489912541, 20183, 27825, 35467, 43109, 50751, 58393 anti-influenza_Chain4900 12542, 20184, 27826, 35468, 43110, 50752, 58394anti-influenza_Chain 4901 12543, 20185, 27827, 35469, 43111, 50753,58395 anti-influenza_Chain 4902 12544, 20186, 27828, 35470, 43112,50754, 58396 anti-influenza_Chain 4903 12545, 20187, 27829, 35471,43113, 50755, 58397 anti-influenza_Chain 4904 12546, 20188, 27830,35472, 43114, 50756, 58398 anti-influenza_Chain 4905 12547, 20189,27831, 35473, 43115, 50757, 58399 anti-influenza_Chain 4906 12548,20190, 27832, 35474, 43116, 50758, 58400 anti-influenza_Chain 490712549, 20191, 27833, 35475, 43117, 50759, 58401 anti-influenza_Chain4908 12550, 20192, 27834, 35476, 43118, 50760, 58402anti-influenza_Chain 4909 12551, 20193, 27835, 35477, 43119, 50761,58403 anti-influenza_Chain 4910 12552, 20194, 27836, 35478, 43120,50762, 58404 anti-influenza_Chain 4911 12553, 20195, 27837, 35479,43121, 50763, 58405 anti-influenza_Chain 4912 12554, 20196, 27838,35480, 43122, 50764, 58406 anti-influenza_Chain 4913 12555, 20197,27839, 35481, 43123, 50765, 58407 anti-influenza_Chain 4914 12556,20198, 27840, 35482, 43124, 50766, 58408 anti-influenza_Chain 491512557, 20199, 27841, 35483, 43125, 50767, 58409 anti-influenza_Chain4916 12558, 20200, 27842, 35484, 43126, 50768, 58410anti-influenza_Chain 4917 12559, 20201, 27843, 35485, 43127, 50769,58411 anti-influenza_Chain 4918 12560, 20202, 27844, 35486, 43128,50770, 58412 anti-influenza_Chain 4919 12561, 20203, 27845, 35487,43129, 50771, 58413 anti-influenza_Chain 4920 12562, 20204, 27846,35488, 43130, 50772, 58414 anti-influenza_Chain 4921 12563, 20205,27847, 35489, 43131, 50773, 58415 anti-influenza_Chain 4922 12564,20206, 27848, 35490, 43132, 50774, 58416 anti-influenza_Chain 492312565, 20207, 27849, 35491, 43133, 50775, 58417 anti-influenza_Chain4924 12566, 20208, 27850, 35492, 43134, 50776, 58418anti-influenza_Chain 4925 12567, 20209, 27851, 35493, 43135, 50777,58419 anti-influenza_Chain 4926 12568, 20210, 27852, 35494, 43136,50778, 58420 anti-influenza_Chain 4927 12569, 20211, 27853, 35495,43137, 50779, 58421 anti-influenza_Chain 4928 12570, 20212, 27854,35496, 43138, 50780, 58422 anti-influenza_Chain 4929 12571, 20213,27855, 35497, 43139, 50781, 58423 anti-influenza_Chain 4930 12572,20214, 27856, 35498, 43140, 50782, 58424 anti-influenza_Chain 493112573, 20215, 27857, 35499, 43141, 50783, 58425 anti-influenza_Chain4932 12574, 20216, 27858, 35500, 43142, 50784, 58426anti-influenza_Chain 4933 12575, 20217, 27859, 35501, 43143, 50785,58427 anti-influenza_Chain 4934 12576, 20218, 27860, 35502, 43144,50786, 58428 anti-influenza_Chain 4935 12577, 20219, 27861, 35503,43145, 50787, 58429 anti-influenza_Chain 4936 12578, 20220, 27862,35504, 43146, 50788, 58430 anti-influenza_Chain 4937 12579, 20221,27863, 35505, 43147, 50789, 58431 anti-influenza_Chain 4938 12580,20222, 27864, 35506, 43148, 50790, 58432 anti-influenza_Chain 493912581, 20223, 27865, 35507, 43149, 50791, 58433 anti-influenza_Chain4940 12582, 20224, 27866, 35508, 43150, 50792, 58434anti-influenza_Chain 4941 12583, 20225, 27867, 35509, 43151, 50793,58435 anti-influenza_Chain 4942 12584, 20226, 27868, 35510, 43152,50794, 58436 anti-influenza_Chain 4943 12585, 20227, 27869, 35511,43153, 50795, 58437 anti-influenza_Chain 4944 12586, 20228, 27870,35512, 43154, 50796, 58438 anti-influenza_Chain 4945 12587, 20229,27871, 35513, 43155, 50797, 58439 anti-influenza_Chain 4946 12588,20230, 27872, 35514, 43156, 50798, 58440 anti-influenza_Chain 494712589, 20231, 27873, 35515, 43157, 50799, 58441 anti-influenza_Chain4948 12590, 20232, 27874, 35516, 43158, 50800, 58442anti-influenza_Chain 4949 12591, 20233, 27875, 35517, 43159, 50801,58443 anti-influenza_Chain 4950 12592, 20234, 27876, 35518, 43160,50802, 58444 anti-influenza_Chain 4951 12593, 20235, 27877, 35519,43161, 50803, 58445 anti-influenza_Chain 4952 12594, 20236, 27878,35520, 43162, 50804, 58446 anti-influenza_Chain 4953 12595, 20237,27879, 35521, 43163, 50805, 58447 anti-influenza_Chain 4954 12596,20238, 27880, 35522, 43164, 50806, 58448 anti-influenza_Chain 495512597, 20239, 27881, 35523, 43165, 50807, 58449 anti-influenza_Chain4956 12598, 20240, 27882, 35524, 43166, 50808, 58450anti-influenza_Chain 4957 12599, 20241, 27883, 35525, 43167, 50809,58451 anti-influenza_Chain 4958 12600, 20242, 27884, 35526, 43168,50810, 58452 anti-influenza_Chain 4959 12601, 20243, 27885, 35527,43169, 50811, 58453 anti-influenza_Chain 4960 12602, 20244, 27886,35528, 43170, 50812, 58454 anti-influenza_Chain 4961 12603, 20245,27887, 35529, 43171, 50813, 58455 anti-influenza_Chain 4962 12604,20246, 27888, 35530, 43172, 50814, 58456 anti-influenza_Chain 496312605, 20247, 27889, 35531, 43173, 50815, 58457 anti-influenza_Chain4964 12606, 20248, 27890, 35532, 43174, 50816, 58458anti-influenza_Chain 4965 12607, 20249, 27891, 35533, 43175, 50817,58459 anti-influenza_Chain 4966 12608, 20250, 27892, 35534, 43176,50818, 58460 anti-influenza_Chain 4967 12609, 20251, 27893, 35535,43177, 50819, 58461 anti-influenza_Chain 4968 12610, 20252, 27894,35536, 43178, 50820, 58462 anti-influenza_Chain 4969 12611, 20253,27895, 35537, 43179, 50821, 58463 anti-influenza_Chain 4970 12612,20254, 27896, 35538, 43180, 50822, 58464 anti-influenza_Chain 497112613, 20255, 27897, 35539, 43181, 50823, 58465 anti-influenza_Chain4972 12614, 20256, 27898, 35540, 43182, 50824, 58466anti-influenza_Chain 4973 12615, 20257, 27899, 35541, 43183, 50825,58467 anti-influenza_Chain 4974 12616, 20258, 27900, 35542, 43184,50826, 58468 anti-influenza_Chain 4975 12617, 20259, 27901, 35543,43185, 50827, 58469 anti-influenza_Chain 4976 12618, 20260, 27902,35544, 43186, 50828, 58470 anti-influenza_Chain 4977 12619, 20261,27903, 35545, 43187, 50829, 58471 anti-influenza_Chain 4978 12620,20262, 27904, 35546, 43188, 50830, 58472 anti-influenza_Chain 497912621, 20263, 27905, 35547, 43189, 50831, 58473 anti-influenza_Chain4980 12622, 20264, 27906, 35548, 43190, 50832, 58474anti-influenza_Chain 4981 12623, 20265, 27907, 35549, 43191, 50833,58475 anti-influenza_Chain 4982 12624, 20266, 27908, 35550, 43192,50834, 58476 anti-influenza_Chain 4983 12625, 20267, 27909, 35551,43193, 50835, 58477 anti-influenza_Chain 4984 12626, 20268, 27910,35552, 43194, 50836, 58478 anti-influenza_Chain 4985 12627, 20269,27911, 35553, 43195, 50837, 58479 anti-influenza_Chain 4986 12628,20270, 27912, 35554, 43196, 50838, 58480 anti-influenza_Chain 498712629, 20271, 27913, 35555, 43197, 50839, 58481 anti-influenza_Chain4988 12630, 20272, 27914, 35556, 43198, 50840, 58482anti-influenza_Chain 4989 12631, 20273, 27915, 35557, 43199, 50841,58483 anti-influenza_Chain 4990 12632, 20274, 27916, 35558, 43200,50842, 58484 anti-influenza_Chain 4991 12633, 20275, 27917, 35559,43201, 50843, 58485 anti-influenza_Chain 4992 12634, 20276, 27918,35560, 43202, 50844, 58486 anti-influenza_Chain 4993 12635, 20277,27919, 35561, 43203, 50845, 58487 anti-influenza_Chain 4994 12636,20278, 27920, 35562, 43204, 50846, 58488 anti-influenza_Chain 499512637, 20279, 27921, 35563, 43205, 50847, 58489 anti-influenza_Chain4996 12638, 20280, 27922, 35564, 43206, 50848, 58490anti-influenza_Chain 4997 12639, 20281, 27923, 35565, 43207, 50849,58491 anti-influenza_Chain 4998 12640, 20282, 27924, 35566, 43208,50850, 58492 anti-influenza_Chain 4999 12641, 20283, 27925, 35567,43209, 50851, 58493 anti-influenza_Chain 5000 12642, 20284, 27926,35568, 43210, 50852, 58494 anti-influenza_Chain 5001 12643, 20285,27927, 35569, 43211, 50853, 58495 anti-influenza_Chain 5002 12644,20286, 27928, 35570, 43212, 50854, 58496 anti-influenza_Chain 500312645, 20287, 27929, 35571, 43213, 50855, 58497 anti-influenza_Chain5004 12646, 20288, 27930, 35572, 43214, 50856, 58498anti-influenza_Chain 5005 12647, 20289, 27931, 35573, 43215, 50857,58499 anti-influenza_Chain 5006 12648, 20290, 27932, 35574, 43216,50858, 58500 anti-influenza_Chain 5007 12649, 20291, 27933, 35575,43217, 50859, 58501 anti-influenza_Chain 5008 12650, 20292, 27934,35576, 43218, 50860, 58502 anti-influenza_Chain 5009 12651, 20293,27935, 35577, 43219, 50861, 58503 anti-influenza_Chain 5010 12652,20294, 27936, 35578, 43220, 50862, 58504 anti-influenza_Chain 501112653, 20295, 27937, 35579, 43221, 50863, 58505 anti-influenza_Chain5012 12654, 20296, 27938, 35580, 43222, 50864, 58506anti-influenza_Chain 5013 12655, 20297, 27939, 35581, 43223, 50865,58507 anti-influenza_Chain 5014 12656, 20298, 27940, 35582, 43224,50866, 58508 anti-influenza_Chain 5015 12657, 20299, 27941, 35583,43225, 50867, 58509 anti-influenza_Chain 5016 12658, 20300, 27942,35584, 43226, 50868, 58510 anti-influenza_Chain 5017 12659, 20301,27943, 35585, 43227, 50869, 58511 anti-influenza_Chain 5018 12660,20302, 27944, 35586, 43228, 50870, 58512 anti-influenza_Chain 501912661, 20303, 27945, 35587, 43229, 50871, 58513 anti-influenza_Chain5020 12662, 20304, 27946, 35588, 43230, 50872, 58514anti-influenza_Chain 5021 12663, 20305, 27947, 35589, 43231, 50873,58515 anti-influenza_Chain 5022 12664, 20306, 27948, 35590, 43232,50874, 58516 anti-influenza_Chain 5023 12665, 20307, 27949, 35591,43233, 50875, 58517 anti-influenza_Chain 5024 12666, 20308, 27950,35592, 43234, 50876, 58518 anti-influenza_Chain 5025 12667, 20309,27951, 35593, 43235, 50877, 58519 anti-influenza_Chain 5026 12668,20310, 27952, 35594, 43236, 50878, 58520 anti-influenza_Chain 502712669, 20311, 27953, 35595, 43237, 50879, 58521 anti-influenza_Chain5028 12670, 20312, 27954, 35596, 43238, 50880, 58522anti-influenza_Chain 5029 12671, 20313, 27955, 35597, 43239, 50881,58523 anti-influenza_Chain 5030 12672, 20314, 27956, 35598, 43240,50882, 58524 anti-influenza_Chain 5031 12673, 20315, 27957, 35599,43241, 50883, 58525 anti-influenza_Chain 5032 12674, 20316, 27958,35600, 43242, 50884, 58526 anti-influenza_Chain 5033 12675, 20317,27959, 35601, 43243, 50885, 58527 anti-influenza_Chain 5034 12676,20318, 27960, 35602, 43244, 50886, 58528 anti-influenza_Chain 503512677, 20319, 27961, 35603, 43245, 50887, 58529 anti-influenza_Chain5036 12678, 20320, 27962, 35604, 43246, 50888, 58530anti-influenza_Chain 5037 12679, 20321, 27963, 35605, 43247, 50889,58531 anti-influenza_Chain 5038 12680, 20322, 27964, 35606, 43248,50890, 58532 anti-influenza_Chain 5039 12681, 20323, 27965, 35607,43249, 50891, 58533 anti-influenza_Chain 5040 12682, 20324, 27966,35608, 43250, 50892, 58534 anti-influenza_Chain 5041 12683, 20325,27967, 35609, 43251, 50893, 58535 anti-influenza_Chain 5042 12684,20326, 27968, 35610, 43252, 50894, 58536 anti-influenza_Chain 504312685, 20327, 27969, 35611, 43253, 50895, 58537 anti-influenza_Chain5044 12686, 20328, 27970, 35612, 43254, 50896, 58538anti-influenza_Chain 5045 12687, 20329, 27971, 35613, 43255, 50897,58539 anti-influenza_Chain 5046 12688, 20330, 27972, 35614, 43256,50898, 58540 anti-influenza_Chain 5047 12689, 20331, 27973, 35615,43257, 50899, 58541 anti-influenza_Chain 5048 12690, 20332, 27974,35616, 43258, 50900, 58542 anti-influenza_Chain 5049 12691, 20333,27975, 35617, 43259, 50901, 58543 anti-influenza_Chain 5050 12692,20334, 27976, 35618, 43260, 50902, 58544 anti-influenza_Chain 505112693, 20335, 27977, 35619, 43261, 50903, 58545 anti-influenza_Chain5052 12694, 20336, 27978, 35620, 43262, 50904, 58546anti-influenza_Chain 5053 12695, 20337, 27979, 35621, 43263, 50905,58547 anti-influenza_Chain 5054 12696, 20338, 27980, 35622, 43264,50906, 58548 anti-influenza_Chain 5055 12697, 20339, 27981, 35623,43265, 50907, 58549 anti-influenza_Chain 5056 12698, 20340, 27982,35624, 43266, 50908, 58550 anti-influenza_Chain 5057 12699, 20341,27983, 35625, 43267, 50909, 58551 anti-influenza_Chain 5058 12700,20342, 27984, 35626, 43268, 50910, 58552 anti-influenza_Chain 505912701, 20343, 27985, 35627, 43269, 50911, 58553 anti-influenza_Chain5060 12702, 20344, 27986, 35628, 43270, 50912, 58554anti-influenza_Chain 5061 12703, 20345, 27987, 35629, 43271, 50913,58555 anti-influenza_Chain 5062 12704, 20346, 27988, 35630, 43272,50914, 58556 anti-influenza_Chain 5063 12705, 20347, 27989, 35631,43273, 50915, 58557 anti-influenza_Chain 5064 12706, 20348, 27990,35632, 43274, 50916, 58558 anti-influenza_Chain 5065 12707, 20349,27991, 35633, 43275, 50917, 58559 anti-influenza_Chain 5066 12708,20350, 27992, 35634, 43276, 50918, 58560 anti-influenza_Chain 506712709, 20351, 27993, 35635, 43277, 50919, 58561 anti-influenza_Chain5068 12710, 20352, 27994, 35636, 43278, 50920, 58562anti-influenza_Chain 5069 12711, 20353, 27995, 35637, 43279, 50921,58563 anti-influenza_Chain 5070 12712, 20354, 27996, 35638, 43280,50922, 58564 anti-influenza_Chain 5071 12713, 20355, 27997, 35639,43281, 50923, 58565 anti-influenza_Chain 5072 12714, 20356, 27998,35640, 43282, 50924, 58566 anti-influenza_Chain 5073 12715, 20357,27999, 35641, 43283, 50925, 58567 anti-influenza_Chain 5074 12716,20358, 28000, 35642, 43284, 50926, 58568 anti-influenza_Chain 507512717, 20359, 28001, 35643, 43285, 50927, 58569 anti-influenza_Chain5076 12718, 20360, 28002, 35644, 43286, 50928, 58570anti-influenza_Chain 5077 12719, 20361, 28003, 35645, 43287, 50929,58571 anti-influenza_Chain 5078 12720, 20362, 28004, 35646, 43288,50930, 58572 anti-influenza_Chain 5079 12721, 20363, 28005, 35647,43289, 50931, 58573 anti-influenza_Chain 5080 12722, 20364, 28006,35648, 43290, 50932, 58574 anti-influenza_Chain 5081 12723, 20365,28007, 35649, 43291, 50933, 58575 anti-influenza_Chain 5082 12724,20366, 28008, 35650, 43292, 50934, 58576 anti-influenza_Chain 508312725, 20367, 28009, 35651, 43293, 50935, 58577 anti-influenza_Chain5084 12726, 20368, 28010, 35652, 43294, 50936, 58578anti-influenza_Chain 5085 12727, 20369, 28011, 35653, 43295, 50937,58579 anti-influenza_Chain 5086 12728, 20370, 28012, 35654, 43296,50938, 58580 anti-influenza_Chain 5087 12729, 20371, 28013, 35655,43297, 50939, 58581 anti-influenza_Chain 5088 12730, 20372, 28014,35656, 43298, 50940, 58582 anti-influenza_Chain 5089 12731, 20373,28015, 35657, 43299, 50941, 58583 anti-influenza_Chain 5090 12732,20374, 28016, 35658, 43300, 50942, 58584 anti-influenza_Chain 509112733, 20375, 28017, 35659, 43301, 50943, 58585 anti-influenza_Chain5092 12734, 20376, 28018, 35660, 43302, 50944, 58586anti-influenza_Chain 5093 12735, 20377, 28019, 35661, 43303, 50945,58587 anti-influenza_Chain 5094 12736, 20378, 28020, 35662, 43304,50946, 58588 anti-influenza_Chain 5095 12737, 20379, 28021, 35663,43305, 50947, 58589 anti-influenza_Chain 5096 12738, 20380, 28022,35664, 43306, 50948, 58590 anti-influenza_Chain 5097 12739, 20381,28023, 35665, 43307, 50949, 58591 anti-influenza_Chain 5098 12740,20382, 28024, 35666, 43308, 50950, 58592 anti-influenza_Chain 509912741, 20383, 28025, 35667, 43309, 50951, 58593 anti-influenza_Chain5100 12742, 20384, 28026, 35668, 43310, 50952, 58594anti-influenza_Chain 5101 12743, 20385, 28027, 35669, 43311, 50953,58595 anti-influenza_Chain 5102 12744, 20386, 28028, 35670, 43312,50954, 58596 anti-influenza_Chain 5103 12745, 20387, 28029, 35671,43313, 50955, 58597 anti-influenza_Chain 5104 12746, 20388, 28030,35672, 43314, 50956, 58598 anti-influenza_Chain 5105 12747, 20389,28031, 35673, 43315, 50957, 58599 anti-influenza_Chain 5106 12748,20390, 28032, 35674, 43316, 50958, 58600 anti-influenza_Chain 510712749, 20391, 28033, 35675, 43317, 50959, 58601 anti-influenza_Chain5108 12750, 20392, 28034, 35676, 43318, 50960, 58602anti-influenza_Chain 5109 12751, 20393, 28035, 35677, 43319, 50961,58603 anti-influenza_Chain 5110 12752, 20394, 28036, 35678, 43320,50962, 58604 anti-influenza_Chain 5111 12753, 20395, 28037, 35679,43321, 50963, 58605 anti-influenza_Chain 5112 12754, 20396, 28038,35680, 43322, 50964, 58606 anti-influenza_Chain 5113 12755, 20397,28039, 35681, 43323, 50965, 58607 anti-influenza_Chain 5114 12756,20398, 28040, 35682, 43324, 50966, 58608 anti-influenza_Chain 511512757, 20399, 28041, 35683, 43325, 50967, 58609 anti-influenza_Chain5116 12758, 20400, 28042, 35684, 43326, 50968, 58610anti-influenza_Chain 5117 12759, 20401, 28043, 35685, 43327, 50969,58611 anti-influenza_Chain 5118 12760, 20402, 28044, 35686, 43328,50970, 58612 anti-influenza_Chain 5119 12761, 20403, 28045, 35687,43329, 50971, 58613 anti-influenza_Chain 5120 12762, 20404, 28046,35688, 43330, 50972, 58614 anti-influenza_Chain 5121 12763, 20405,28047, 35689, 43331, 50973, 58615 anti-influenza_Chain 5122 12764,20406, 28048, 35690, 43332, 50974, 58616 anti-influenza_Chain 512312765, 20407, 28049, 35691, 43333, 50975, 58617 anti-influenza_Chain5124 12766, 20408, 28050, 35692, 43334, 50976, 58618anti-influenza_Chain 5125 12767, 20409, 28051, 35693, 43335, 50977,58619 anti-influenza_Chain 5126 12768, 20410, 28052, 35694, 43336,50978, 58620 anti-influenza_Chain 5127 12769, 20411, 28053, 35695,43337, 50979, 58621 anti-influenza_Chain 5128 12770, 20412, 28054,35696, 43338, 50980, 58622 anti-influenza_Chain 5129 12771, 20413,28055, 35697, 43339, 50981, 58623 anti-influenza_Chain 5130 12772,20414, 28056, 35698, 43340, 50982, 58624 anti-influenza_Chain 513112773, 20415, 28057, 35699, 43341, 50983, 58625 anti-influenza_Chain5132 12774, 20416, 28058, 35700, 43342, 50984, 58626anti-influenza_Chain 5133 12775, 20417, 28059, 35701, 43343, 50985,58627 anti-influenza_Chain 5134 12776, 20418, 28060, 35702, 43344,50986, 58628 anti-influenza_Chain 5135 12777, 20419, 28061, 35703,43345, 50987, 58629 anti-influenza_Chain 5136 12778, 20420, 28062,35704, 43346, 50988, 58630 anti-influenza_Chain 5137 12779, 20421,28063, 35705, 43347, 50989, 58631 anti-influenza_Chain 5138 12780,20422, 28064, 35706, 43348, 50990, 58632 anti-influenza_Chain 513912781, 20423, 28065, 35707, 43349, 50991, 58633 anti-influenza_Chain5140 12782, 20424, 28066, 35708, 43350, 50992, 58634anti-influenza_Chain 5141 12783, 20425, 28067, 35709, 43351, 50993,58635 anti-influenza_Chain 5142 12784, 20426, 28068, 35710, 43352,50994, 58636 anti-influenza_Chain 5143 12785, 20427, 28069, 35711,43353, 50995, 58637 anti-influenza_Chain 5144 12786, 20428, 28070,35712, 43354, 50996, 58638 anti-influenza_Chain 5145 12787, 20429,28071, 35713, 43355, 50997, 58639 anti-influenza_Chain 5146 12788,20430, 28072, 35714, 43356, 50998, 58640 anti-influenza_Chain 514712789, 20431, 28073, 35715, 43357, 50999, 58641 anti-influenza_Chain5148 12790, 20432, 28074, 35716, 43358, 51000, 58642anti-influenza_Chain 5149 12791, 20433, 28075, 35717, 43359, 51001,58643 anti-influenza_Chain 5150 12792, 20434, 28076, 35718, 43360,51002, 58644 anti-influenza_Chain 5151 12793, 20435, 28077, 35719,43361, 51003, 58645 anti-influenza_Chain 5152 12794, 20436, 28078,35720, 43362, 51004, 58646 anti-influenza_Chain 5153 12795, 20437,28079, 35721, 43363, 51005, 58647 anti-influenza_Chain 5154 12796,20438, 28080, 35722, 43364, 51006, 58648 anti-influenza_Chain 515512797, 20439, 28081, 35723, 43365, 51007, 58649 anti-influenza_Chain5156 12798, 20440, 28082, 35724, 43366, 51008, 58650anti-influenza_Chain 5157 12799, 20441, 28083, 35725, 43367, 51009,58651 anti-influenza_Chain 5158 12800, 20442, 28084, 35726, 43368,51010, 58652 anti-influenza_Chain 5159 12801, 20443, 28085, 35727,43369, 51011, 58653 anti-influenza_Chain 5160 12802, 20444, 28086,35728, 43370, 51012, 58654 anti-influenza_Chain 5161 12803, 20445,28087, 35729, 43371, 51013, 58655 anti-influenza_Chain 5162 12804,20446, 28088, 35730, 43372, 51014, 58656 anti-influenza_Chain 516312805, 20447, 28089, 35731, 43373, 51015, 58657 anti-influenza_Chain5164 12806, 20448, 28090, 35732, 43374, 51016, 58658anti-influenza_Chain 5165 12807, 20449, 28091, 35733, 43375, 51017,58659 anti-influenza_Chain 5166 12808, 20450, 28092, 35734, 43376,51018, 58660 anti-influenza_Chain 5167 12809, 20451, 28093, 35735,43377, 51019, 58661 anti-influenza_Chain 5168 12810, 20452, 28094,35736, 43378, 51020, 58662 anti-influenza_Chain 5169 12811, 20453,28095, 35737, 43379, 51021, 58663 anti-influenza_Chain 5170 12812,20454, 28096, 35738, 43380, 51022, 58664 anti-influenza_Chain 517112813, 20455, 28097, 35739, 43381, 51023, 58665 anti-influenza_Chain5172 12814, 20456, 28098, 35740, 43382, 51024, 58666anti-influenza_Chain 5173 12815, 20457, 28099, 35741, 43383, 51025,58667 anti-influenza_Chain 5174 12816, 20458, 28100, 35742, 43384,51026, 58668 anti-influenza_Chain 5175 12817, 20459, 28101, 35743,43385, 51027, 58669 anti-influenza_Chain 5176 12818, 20460, 28102,35744, 43386, 51028, 58670 anti-influenza_Chain 5177 12819, 20461,28103, 35745, 43387, 51029, 58671 anti-influenza_Chain 5178 12820,20462, 28104, 35746, 43388, 51030, 58672 anti-influenza_Chain 517912821, 20463, 28105, 35747, 43389, 51031, 58673 anti-influenza_Chain5180 12822, 20464, 28106, 35748, 43390, 51032, 58674anti-influenza_Chain 5181 12823, 20465, 28107, 35749, 43391, 51033,58675 anti-influenza_Chain 5182 12824, 20466, 28108, 35750, 43392,51034, 58676 anti-influenza_Chain 5183 12825, 20467, 28109, 35751,43393, 51035, 58677 anti-influenza_Chain 5184 12826, 20468, 28110,35752, 43394, 51036, 58678 anti-influenza_Chain 5185 12827, 20469,28111, 35753, 43395, 51037, 58679 anti-influenza_Chain 5186 12828,20470, 28112, 35754, 43396, 51038, 58680 anti-influenza_Chain 518712829, 20471, 28113, 35755, 43397, 51039, 58681 anti-influenza_Chain5188 12830, 20472, 28114, 35756, 43398, 51040, 58682anti-influenza_Chain 5189 12831, 20473, 28115, 35757, 43399, 51041,58683 anti-influenza_Chain 5190 12832, 20474, 28116, 35758, 43400,51042, 58684 anti-influenza_Chain 5191 12833, 20475, 28117, 35759,43401, 51043, 58685 anti-influenza_Chain 5192 12834, 20476, 28118,35760, 43402, 51044, 58686 anti-influenza_Chain 5193 12835, 20477,28119, 35761, 43403, 51045, 58687 anti-influenza_Chain 5194 12836,20478, 28120, 35762, 43404, 51046, 58688 anti-influenza_Chain 519512837, 20479, 28121, 35763, 43405, 51047, 58689 anti-influenza_Chain5196 12838, 20480, 28122, 35764, 43406, 51048, 58690anti-influenza_Chain 5197 12839, 20481, 28123, 35765, 43407, 51049,58691 anti-influenza_Chain 5198 12840, 20482, 28124, 35766, 43408,51050, 58692 anti-influenza_Chain 5199 12841, 20483, 28125, 35767,43409, 51051, 58693 anti-influenza_Chain 5200 12842, 20484, 28126,35768, 43410, 51052, 58694 anti-influenza_Chain 5201 12843, 20485,28127, 35769, 43411, 51053, 58695 anti-influenza_Chain 5202 12844,20486, 28128, 35770, 43412, 51054, 58696 anti-influenza_Chain 520312845, 20487, 28129, 35771, 43413, 51055, 58697 anti-influenza_Chain5204 12846, 20488, 28130, 35772, 43414, 51056, 58698anti-influenza_Chain 5205 12847, 20489, 28131, 35773, 43415, 51057,58699 anti-influenza_Chain 5206 12848, 20490, 28132, 35774, 43416,51058, 58700 anti-influenza_Chain 5207 12849, 20491, 28133, 35775,43417, 51059, 58701 anti-influenza_Chain 5208 12850, 20492, 28134,35776, 43418, 51060, 58702 anti-influenza_Chain 5209 12851, 20493,28135, 35777, 43419, 51061, 58703 anti-influenza_Chain 5210 12852,20494, 28136, 35778, 43420, 51062, 58704 anti-influenza_Chain 521112853, 20495, 28137, 35779, 43421, 51063, 58705 anti-influenza_Chain5212 12854, 20496, 28138, 35780, 43422, 51064, 58706anti-influenza_Chain 5213 12855, 20497, 28139, 35781, 43423, 51065,58707 anti-influenza_Chain 5214 12856, 20498, 28140, 35782, 43424,51066, 58708 anti-influenza_Chain 5215 12857, 20499, 28141, 35783,43425, 51067, 58709 anti-influenza_Chain 5216 12858, 20500, 28142,35784, 43426, 51068, 58710 anti-influenza_Chain 5217 12859, 20501,28143, 35785, 43427, 51069, 58711 anti-influenza_Chain 5218 12860,20502, 28144, 35786, 43428, 51070, 58712 anti-influenza_Chain 521912861, 20503, 28145, 35787, 43429, 51071, 58713 anti-influenza_Chain5220 12862, 20504, 28146, 35788, 43430, 51072, 58714anti-influenza_Chain 5221 12863, 20505, 28147, 35789, 43431, 51073,58715 anti-influenza_Chain 5222 12864, 20506, 28148, 35790, 43432,51074, 58716 anti-influenza_Chain 5223 12865, 20507, 28149, 35791,43433, 51075, 58717 anti-influenza_Chain 5224 12866, 20508, 28150,35792, 43434, 51076, 58718 anti-influenza_Chain 5225 12867, 20509,28151, 35793, 43435, 51077, 58719 anti-influenza_Chain 5226 12868,20510, 28152, 35794, 43436, 51078, 58720 anti-influenza_Chain 522712869, 20511, 28153, 35795, 43437, 51079, 58721 anti-influenza_Chain5228 12870, 20512, 28154, 35796, 43438, 51080, 58722anti-influenza_Chain 5229 12871, 20513, 28155, 35797, 43439, 51081,58723 anti-influenza_Chain 5230 12872, 20514, 28156, 35798, 43440,51082, 58724 anti-influenza_Chain 5231 12873, 20515, 28157, 35799,43441, 51083, 58725 anti-influenza_Chain 5232 12874, 20516, 28158,35800, 43442, 51084, 58726 anti-influenza_Chain 5233 12875, 20517,28159, 35801, 43443, 51085, 58727 anti-influenza_Chain 5234 12876,20518, 28160, 35802, 43444, 51086, 58728 anti-influenza_Chain 523512877, 20519, 28161, 35803, 43445, 51087, 58729 anti-influenza_Chain5236 12878, 20520, 28162, 35804, 43446, 51088, 58730anti-influenza_Chain 5237 12879, 20521, 28163, 35805, 43447, 51089,58731 anti-influenza_Chain 5238 12880, 20522, 28164, 35806, 43448,51090, 58732 anti-influenza_Chain 5239 12881, 20523, 28165, 35807,43449, 51091, 58733 anti-influenza_Chain 5240 12882, 20524, 28166,35808, 43450, 51092, 58734 anti-influenza_Chain 5241 12883, 20525,28167, 35809, 43451, 51093, 58735 anti-influenza_Chain 5242 12884,20526, 28168, 35810, 43452, 51094, 58736 anti-influenza_Chain 524312885, 20527, 28169, 35811, 43453, 51095, 58737 anti-influenza_Chain5244 12886, 20528, 28170, 35812, 43454, 51096, 58738anti-influenza_Chain 5245 12887, 20529, 28171, 35813, 43455, 51097,58739 anti-influenza_Chain 5246 12888, 20530, 28172, 35814, 43456,51098, 58740 anti-influenza_Chain 5247 12889, 20531, 28173, 35815,43457, 51099, 58741 anti-influenza_Chain 5248 12890, 20532, 28174,35816, 43458, 51100, 58742 anti-influenza_Chain 5249 12891, 20533,28175, 35817, 43459, 51101, 58743 anti-influenza_Chain 5250 12892,20534, 28176, 35818, 43460, 51102, 58744 anti-influenza_Chain 525112893, 20535, 28177, 35819, 43461, 51103, 58745 anti-influenza_Chain5252 12894, 20536, 28178, 35820, 43462, 51104, 58746anti-influenza_Chain 5253 12895, 20537, 28179, 35821, 43463, 51105,58747 anti-influenza_Chain 5254 12896, 20538, 28180, 35822, 43464,51106, 58748 anti-influenza_Chain 5255 12897, 20539, 28181, 35823,43465, 51107, 58749 anti-influenza_Chain 5256 12898, 20540, 28182,35824, 43466, 51108, 58750 anti-influenza_Chain 5257 12899, 20541,28183, 35825, 43467, 51109, 58751 anti-influenza_Chain 5258 12900,20542, 28184, 35826, 43468, 51110, 58752 anti-influenza_Chain 525912901, 20543, 28185, 35827, 43469, 51111, 58753 anti-influenza_Chain5260 12902, 20544, 28186, 35828, 43470, 51112, 58754anti-influenza_Chain 5261 12903, 20545, 28187, 35829, 43471, 51113,58755 anti-influenza_Chain 5262 12904, 20546, 28188, 35830, 43472,51114, 58756 anti-influenza_Chain 5263 12905, 20547, 28189, 35831,43473, 51115, 58757 anti-influenza_Chain 5264 12906, 20548, 28190,35832, 43474, 51116, 58758 anti-influenza_Chain 5265 12907, 20549,28191, 35833, 43475, 51117, 58759 anti-influenza_Chain 5266 12908,20550, 28192, 35834, 43476, 51118, 58760 anti-influenza_Chain 526712909, 20551, 28193, 35835, 43477, 51119, 58761 anti-influenza_Chain5268 12910, 20552, 28194, 35836, 43478, 51120, 58762anti-influenza_Chain 5269 12911, 20553, 28195, 35837, 43479, 51121,58763 anti-influenza_Chain 5270 12912, 20554, 28196, 35838, 43480,51122, 58764 anti-influenza_Chain 5271 12913, 20555, 28197, 35839,43481, 51123, 58765 anti-influenza_Chain 5272 12914, 20556, 28198,35840, 43482, 51124, 58766 anti-influenza_Chain 5273 12915, 20557,28199, 35841, 43483, 51125, 58767 anti-influenza_Chain 5274 12916,20558, 28200, 35842, 43484, 51126, 58768 anti-influenza_Chain 527512917, 20559, 28201, 35843, 43485, 51127, 58769 anti-influenza_Chain5276 12918, 20560, 28202, 35844, 43486, 51128, 58770anti-influenza_Chain 5277 12919, 20561, 28203, 35845, 43487, 51129,58771 anti-influenza_Chain 5278 12920, 20562, 28204, 35846, 43488,51130, 58772 anti-influenza_Chain 5279 12921, 20563, 28205, 35847,43489, 51131, 58773 anti-influenza_Chain 5280 12922, 20564, 28206,35848, 43490, 51132, 58774 anti-influenza_Chain 5281 12923, 20565,28207, 35849, 43491, 51133, 58775 anti-influenza_Chain 5282 12924,20566, 28208, 35850, 43492, 51134, 58776 anti-influenza_Chain 528312925, 20567, 28209, 35851, 43493, 51135, 58777 anti-influenza_Chain5284 12926, 20568, 28210, 35852, 43494, 51136, 58778anti-influenza_Chain 5285 12927, 20569, 28211, 35853, 43495, 51137,58779 anti-influenza_Chain 5286 12928, 20570, 28212, 35854, 43496,51138, 58780 anti-influenza_Chain 5287 12929, 20571, 28213, 35855,43497, 51139, 58781 anti-influenza_Chain 5288 12930, 20572, 28214,35856, 43498, 51140, 58782 anti-influenza_Chain 5289 12931, 20573,28215, 35857, 43499, 51141, 58783 anti-influenza_Chain 5290 12932,20574, 28216, 35858, 43500, 51142, 58784 anti-influenza_Chain 529112933, 20575, 28217, 35859, 43501, 51143, 58785 anti-influenza_Chain5292 12934, 20576, 28218, 35860, 43502, 51144, 58786anti-influenza_Chain 5293 12935, 20577, 28219, 35861, 43503, 51145,58787 anti-influenza_Chain 5294 12936, 20578, 28220, 35862, 43504,51146, 58788 anti-influenza_Chain 5295 12937, 20579, 28221, 35863,43505, 51147, 58789 anti-influenza_Chain 5296 12938, 20580, 28222,35864, 43506, 51148, 58790 anti-influenza_Chain 5297 12939, 20581,28223, 35865, 43507, 51149, 58791 anti-influenza_Chain 5298 12940,20582, 28224, 35866, 43508, 51150, 58792 anti-influenza_Chain 529912941, 20583, 28225, 35867, 43509, 51151, 58793 anti-influenza_Chain5300 12942, 20584, 28226, 35868, 43510, 51152, 58794anti-influenza_Chain 5301 12943, 20585, 28227, 35869, 43511, 51153,58795 anti-influenza_Chain 5302 12944, 20586, 28228, 35870, 43512,51154, 58796 anti-influenza_Chain 5303 12945, 20587, 28229, 35871,43513, 51155, 58797 anti-influenza_Chain 5304 12946, 20588, 28230,35872, 43514, 51156, 58798 anti-influenza_Chain 5305 12947, 20589,28231, 35873, 43515, 51157, 58799 anti-influenza_Chain 5306 12948,20590, 28232, 35874, 43516, 51158, 58800 anti-influenza_Chain 530712949, 20591, 28233, 35875, 43517, 51159, 58801 anti-influenza_Chain5308 12950, 20592, 28234, 35876, 43518, 51160, 58802anti-influenza_Chain 5309 12951, 20593, 28235, 35877, 43519, 51161,58803 anti-influenza_Chain 5310 12952, 20594, 28236, 35878, 43520,51162, 58804 anti-influenza_Chain 5311 12953, 20595, 28237, 35879,43521, 51163, 58805 anti-influenza_Chain 5312 12954, 20596, 28238,35880, 43522, 51164, 58806 anti-influenza_Chain 5313 12955, 20597,28239, 35881, 43523, 51165, 58807 anti-influenza_Chain 5314 12956,20598, 28240, 35882, 43524, 51166, 58808 anti-influenza_Chain 531512957, 20599, 28241, 35883, 43525, 51167, 58809 anti-influenza_Chain5316 12958, 20600, 28242, 35884, 43526, 51168, 58810anti-influenza_Chain 5317 12959, 20601, 28243, 35885, 43527, 51169,58811 anti-influenza_Chain 5318 12960, 20602, 28244, 35886, 43528,51170, 58812 anti-influenza_Chain 5319 12961, 20603, 28245, 35887,43529, 51171, 58813 anti-influenza_Chain 5320 12962, 20604, 28246,35888, 43530, 51172, 58814 anti-influenza_Chain 5321 12963, 20605,28247, 35889, 43531, 51173, 58815 anti-influenza_Chain 5322 12964,20606, 28248, 35890, 43532, 51174, 58816 anti-influenza_Chain 532312965, 20607, 28249, 35891, 43533, 51175, 58817 anti-influenza_Chain5324 12966, 20608, 28250, 35892, 43534, 51176, 58818anti-influenza_Chain 5325 12967, 20609, 28251, 35893, 43535, 51177,58819 anti-influenza_Chain 5326 12968, 20610, 28252, 35894, 43536,51178, 58820 anti-influenza_Chain 5327 12969, 20611, 28253, 35895,43537, 51179, 58821 anti-influenza_Chain 5328 12970, 20612, 28254,35896, 43538, 51180, 58822 anti-influenza_Chain 5329 12971, 20613,28255, 35897, 43539, 51181, 58823 anti-influenza_Chain 5330 12972,20614, 28256, 35898, 43540, 51182, 58824 anti-influenza_Chain 533112973, 20615, 28257, 35899, 43541, 51183, 58825 anti-influenza_Chain5332 12974, 20616, 28258, 35900, 43542, 51184, 58826anti-influenza_Chain 5333 12975, 20617, 28259, 35901, 43543, 51185,58827 anti-influenza_Chain 5334 12976, 20618, 28260, 35902, 43544,51186, 58828 anti-influenza_Chain 5335 12977, 20619, 28261, 35903,43545, 51187, 58829 anti-influenza_Chain 5336 12978, 20620, 28262,35904, 43546, 51188, 58830 anti-influenza_Chain 5337 12979, 20621,28263, 35905, 43547, 51189, 58831 anti-influenza_Chain 5338 12980,20622, 28264, 35906, 43548, 51190, 58832 anti-influenza_Chain 533912981, 20623, 28265, 35907, 43549, 51191, 58833 anti-influenza_Chain5340 12982, 20624, 28266, 35908, 43550, 51192, 58834anti-influenza_Chain 5341 12983, 20625, 28267, 35909, 43551, 51193,58835 anti-influenza_Chain 5342 12984, 20626, 28268, 35910, 43552,51194, 58836 anti-influenza_Chain 5343 12985, 20627, 28269, 35911,43553, 51195, 58837 anti-influenza_Chain 5344 12986, 20628, 28270,35912, 43554, 51196, 58838 anti-influenza_Chain 5345 12987, 20629,28271, 35913, 43555, 51197, 58839 anti-influenza_Chain 5346 12988,20630, 28272, 35914, 43556, 51198, 58840 anti-influenza_Chain 534712989, 20631, 28273, 35915, 43557, 51199, 58841 anti-influenza_Chain5348 12990, 20632, 28274, 35916, 43558, 51200, 58842anti-influenza_Chain 5349 12991, 20633, 28275, 35917, 43559, 51201,58843 anti-influenza_Chain 5350 12992, 20634, 28276, 35918, 43560,51202, 58844 anti-influenza_Chain 5351 12993, 20635, 28277, 35919,43561, 51203, 58845 anti-influenza_Chain 5352 12994, 20636, 28278,35920, 43562, 51204, 58846 anti-influenza_Chain 5353 12995, 20637,28279, 35921, 43563, 51205, 58847 anti-influenza_Chain 5354 12996,20638, 28280, 35922, 43564, 51206, 58848 anti-influenza_Chain 535512997, 20639, 28281, 35923, 43565, 51207, 58849 anti-influenza_Chain5356 12998, 20640, 28282, 35924, 43566, 51208, 58850anti-influenza_Chain 5357 12999, 20641, 28283, 35925, 43567, 51209,58851 anti-influenza_Chain 5358 13000, 20642, 28284, 35926, 43568,51210, 58852 anti-influenza_Chain 5359 13001, 20643, 28285, 35927,43569, 51211, 58853 anti-influenza_Chain 5360 13002, 20644, 28286,35928, 43570, 51212, 58854 anti-influenza_Chain 5361 13003, 20645,28287, 35929, 43571, 51213, 58855 anti-influenza_Chain 5362 13004,20646, 28288, 35930, 43572, 51214, 58856 anti-influenza_Chain 536313005, 20647, 28289, 35931, 43573, 51215, 58857 anti-influenza_Chain5364 13006, 20648, 28290, 35932, 43574, 51216, 58858anti-influenza_Chain 5365 13007, 20649, 28291, 35933, 43575, 51217,58859 anti-influenza_Chain 5366 13008, 20650, 28292, 35934, 43576,51218, 58860 anti-influenza_Chain 5367 13009, 20651, 28293, 35935,43577, 51219, 58861 anti-influenza_Chain 5368 13010, 20652, 28294,35936, 43578, 51220, 58862 anti-influenza_Chain 5369 13011, 20653,28295, 35937, 43579, 51221, 58863 anti-influenza_Chain 5370 13012,20654, 28296, 35938, 43580, 51222, 58864 anti-influenza_Chain 537113013, 20655, 28297, 35939, 43581, 51223, 58865 anti-influenza_Chain5372 13014, 20656, 28298, 35940, 43582, 51224, 58866anti-influenza_Chain 5373 13015, 20657, 28299, 35941, 43583, 51225,58867 anti-influenza_Chain 5374 13016, 20658, 28300, 35942, 43584,51226, 58868 anti-influenza_Chain 5375 13017, 20659, 28301, 35943,43585, 51227, 58869 anti-influenza_Chain 5376 13018, 20660, 28302,35944, 43586, 51228, 58870 anti-influenza_Chain 5377 13019, 20661,28303, 35945, 43587, 51229, 58871 anti-influenza_Chain 5378 13020,20662, 28304, 35946, 43588, 51230, 58872 anti-influenza_Chain 537913021, 20663, 28305, 35947, 43589, 51231, 58873 anti-influenza_Chain5380 13022, 20664, 28306, 35948, 43590, 51232, 58874anti-influenza_Chain 5381 13023, 20665, 28307, 35949, 43591, 51233,58875 anti-influenza_Chain 5382 13024, 20666, 28308, 35950, 43592,51234, 58876 anti-influenza_Chain 5383 13025, 20667, 28309, 35951,43593, 51235, 58877 anti-influenza_Chain 5384 13026, 20668, 28310,35952, 43594, 51236, 58878 anti-influenza_Chain 5385 13027, 20669,28311, 35953, 43595, 51237, 58879 anti-influenza_Chain 5386 13028,20670, 28312, 35954, 43596, 51238, 58880 anti-influenza_Chain 538713029, 20671, 28313, 35955, 43597, 51239, 58881 anti-influenza_Chain5388 13030, 20672, 28314, 35956, 43598, 51240, 58882anti-influenza_Chain 5389 13031, 20673, 28315, 35957, 43599, 51241,58883 anti-influenza_Chain 5390 13032, 20674, 28316, 35958, 43600,51242, 58884 anti-influenza_Chain 5391 13033, 20675, 28317, 35959,43601, 51243, 58885 anti-influenza_Chain 5392 13034, 20676, 28318,35960, 43602, 51244, 58886 anti-influenza_Chain 5393 13035, 20677,28319, 35961, 43603, 51245, 58887 anti-influenza_Chain 5394 13036,20678, 28320, 35962, 43604, 51246, 58888 anti-influenza_Chain 539513037, 20679, 28321, 35963, 43605, 51247, 58889 anti-influenza_Chain5396 13038, 20680, 28322, 35964, 43606, 51248, 58890anti-influenza_Chain 5397 13039, 20681, 28323, 35965, 43607, 51249,58891 anti-influenza_Chain 5398 13040, 20682, 28324, 35966, 43608,51250, 58892 anti-influenza_Chain 5399 13041, 20683, 28325, 35967,43609, 51251, 58893 anti-influenza_Chain 5400 13042, 20684, 28326,35968, 43610, 51252, 58894 anti-influenza_Chain 5401 13043, 20685,28327, 35969, 43611, 51253, 58895 anti-influenza_Chain 5402 13044,20686, 28328, 35970, 43612, 51254, 58896 anti-influenza_Chain 540313045, 20687, 28329, 35971, 43613, 51255, 58897 anti-influenza_Chain5404 13046, 20688, 28330, 35972, 43614, 51256, 58898anti-influenza_Chain 5405 13047, 20689, 28331, 35973, 43615, 51257,58899 anti-influenza_Chain 5406 13048, 20690, 28332, 35974, 43616,51258, 58900 anti-influenza_Chain 5407 13049, 20691, 28333, 35975,43617, 51259, 58901 anti-influenza_Chain 5408 13050, 20692, 28334,35976, 43618, 51260, 58902 anti-influenza_Chain 5409 13051, 20693,28335, 35977, 43619, 51261, 58903 anti-influenza_Chain 5410 13052,20694, 28336, 35978, 43620, 51262, 58904 anti-influenza_Chain 541113053, 20695, 28337, 35979, 43621, 51263, 58905 anti-influenza_Chain5412 13054, 20696, 28338, 35980, 43622, 51264, 58906anti-influenza_Chain 5413 13055, 20697, 28339, 35981, 43623, 51265,58907 anti-influenza_Chain 5414 13056, 20698, 28340, 35982, 43624,51266, 58908 anti-influenza_Chain 5415 13057, 20699, 28341, 35983,43625, 51267, 58909 anti-influenza_Chain 5416 13058, 20700, 28342,35984, 43626, 51268, 58910 anti-influenza_Chain 5417 13059, 20701,28343, 35985, 43627, 51269, 58911 anti-influenza_Chain 5418 13060,20702, 28344, 35986, 43628, 51270, 58912 anti-influenza_Chain 541913061, 20703, 28345, 35987, 43629, 51271, 58913 anti-influenza_Chain5420 13062, 20704, 28346, 35988, 43630, 51272, 58914anti-influenza_Chain 5421 13063, 20705, 28347, 35989, 43631, 51273,58915 anti-influenza_Chain 5422 13064, 20706, 28348, 35990, 43632,51274, 58916 anti-influenza_Chain 5423 13065, 20707, 28349, 35991,43633, 51275, 58917 anti-influenza_Chain 5424 13066, 20708, 28350,35992, 43634, 51276, 58918 anti-influenza_Chain 5425 13067, 20709,28351, 35993, 43635, 51277, 58919 anti-influenza_Chain 5426 13068,20710, 28352, 35994, 43636, 51278, 58920 anti-influenza_Chain 542713069, 20711, 28353, 35995, 43637, 51279, 58921 anti-influenza_Chain5428 13070, 20712, 28354, 35996, 43638, 51280, 58922anti-influenza_Chain 5429 13071, 20713, 28355, 35997, 43639, 51281,58923 anti-influenza_Chain 5430 13072, 20714, 28356, 35998, 43640,51282, 58924 anti-influenza_Chain 5431 13073, 20715, 28357, 35999,43641, 51283, 58925 anti-influenza_Chain 5432 13074, 20716, 28358,36000, 43642, 51284, 58926 anti-influenza_Chain 5433 13075, 20717,28359, 36001, 43643, 51285, 58927 anti-influenza_Chain 5434 13076,20718, 28360, 36002, 43644, 51286, 58928 anti-influenza_Chain 543513077, 20719, 28361, 36003, 43645, 51287, 58929 anti-influenza_Chain5436 13078, 20720, 28362, 36004, 43646, 51288, 58930anti-influenza_Chain 5437 13079, 20721, 28363, 36005, 43647, 51289,58931 anti-influenza_Chain 5438 13080, 20722, 28364, 36006, 43648,51290, 58932 anti-influenza_Chain 5439 13081, 20723, 28365, 36007,43649, 51291, 58933 anti-influenza_Chain 5440 13082, 20724, 28366,36008, 43650, 51292, 58934 anti-influenza_Chain 5441 13083, 20725,28367, 36009, 43651, 51293, 58935 anti-influenza_Chain 5442 13084,20726, 28368, 36010, 43652, 51294, 58936 anti-influenza_Chain 544313085, 20727, 28369, 36011, 43653, 51295, 58937 anti-influenza_Chain5444 13086, 20728, 28370, 36012, 43654, 51296, 58938anti-influenza_Chain 5445 13087, 20729, 28371, 36013, 43655, 51297,58939 anti-influenza_Chain 5446 13088, 20730, 28372, 36014, 43656,51298, 58940 anti-influenza_Chain 5447 13089, 20731, 28373, 36015,43657, 51299, 58941 anti-influenza_Chain 5448 13090, 20732, 28374,36016, 43658, 51300, 58942 anti-influenza_Chain 5449 13091, 20733,28375, 36017, 43659, 51301, 58943 anti-influenza_Chain 5450 13092,20734, 28376, 36018, 43660, 51302, 58944 anti-influenza_Chain 545113093, 20735, 28377, 36019, 43661, 51303, 58945 anti-influenza_Chain5452 13094, 20736, 28378, 36020, 43662, 51304, 58946anti-influenza_Chain 5453 13095, 20737, 28379, 36021, 43663, 51305,58947 anti-influenza_Chain 5454 13096, 20738, 28380, 36022, 43664,51306, 58948 anti-influenza_Chain 5455 13097, 20739, 28381, 36023,43665, 51307, 58949 anti-influenza_Chain 5456 13098, 20740, 28382,36024, 43666, 51308, 58950 anti-influenza_Chain 5457 13099, 20741,28383, 36025, 43667, 51309, 58951 anti-influenza_Chain 5458 13100,20742, 28384, 36026, 43668, 51310, 58952 anti-influenza_Chain 545913101, 20743, 28385, 36027, 43669, 51311, 58953 anti-influenza_Chain5460 13102, 20744, 28386, 36028, 43670, 51312, 58954anti-influenza_Chain 5461 13103, 20745, 28387, 36029, 43671, 51313,58955 anti-influenza_Chain 5462 13104, 20746, 28388, 36030, 43672,51314, 58956 anti-influenza_Chain 5463 13105, 20747, 28389, 36031,43673, 51315, 58957 anti-influenza_Chain 5464 13106, 20748, 28390,36032, 43674, 51316, 58958 anti-influenza_Chain 5465 13107, 20749,28391, 36033, 43675, 51317, 58959 anti-influenza_Chain 5466 13108,20750, 28392, 36034, 43676, 51318, 58960 anti-influenza_Chain 546713109, 20751, 28393, 36035, 43677, 51319, 58961 anti-influenza_Chain5468 13110, 20752, 28394, 36036, 43678, 51320, 58962anti-influenza_Chain 5469 13111, 20753, 28395, 36037, 43679, 51321,58963 anti-influenza_Chain 5470 13112, 20754, 28396, 36038, 43680,51322, 58964 anti-influenza_Chain 5471 13113, 20755, 28397, 36039,43681, 51323, 58965 anti-influenza_Chain 5472 13114, 20756, 28398,36040, 43682, 51324, 58966 anti-influenza_Chain 5473 13115, 20757,28399, 36041, 43683, 51325, 58967 anti-influenza_Chain 5474 13116,20758, 28400, 36042, 43684, 51326, 58968 anti-influenza_Chain 547513117, 20759, 28401, 36043, 43685, 51327, 58969 anti-influenza_Chain5476 13118, 20760, 28402, 36044, 43686, 51328, 58970anti-influenza_Chain 5477 13119, 20761, 28403, 36045, 43687, 51329,58971 anti-influenza_Chain 5478 13120, 20762, 28404, 36046, 43688,51330, 58972 anti-influenza_Chain 5479 13121, 20763, 28405, 36047,43689, 51331, 58973 anti-influenza_Chain 5480 13122, 20764, 28406,36048, 43690, 51332, 58974 anti-influenza_Chain 5481 13123, 20765,28407, 36049, 43691, 51333, 58975 anti-influenza_Chain 5482 13124,20766, 28408, 36050, 43692, 51334, 58976 anti-influenza_Chain 548313125, 20767, 28409, 36051, 43693, 51335, 58977 anti-influenza_Chain5484 13126, 20768, 28410, 36052, 43694, 51336, 58978anti-influenza_Chain 5485 13127, 20769, 28411, 36053, 43695, 51337,58979 anti-influenza_Chain 5486 13128, 20770, 28412, 36054, 43696,51338, 58980 anti-influenza_Chain 5487 13129, 20771, 28413, 36055,43697, 51339, 58981 anti-influenza_Chain 5488 13130, 20772, 28414,36056, 43698, 51340, 58982 anti-influenza_Chain 5489 13131, 20773,28415, 36057, 43699, 51341, 58983 anti-influenza_Chain 5490 13132,20774, 28416, 36058, 43700, 51342, 58984 anti-influenza_Chain 549113133, 20775, 28417, 36059, 43701, 51343, 58985 anti-influenza_Chain5492 13134, 20776, 28418, 36060, 43702, 51344, 58986anti-influenza_Chain 5493 13135, 20777, 28419, 36061, 43703, 51345,58987 anti-influenza_Chain 5494 13136, 20778, 28420, 36062, 43704,51346, 58988 anti-influenza_Chain 5495 13137, 20779, 28421, 36063,43705, 51347, 58989 anti-influenza_Chain 5496 13138, 20780, 28422,36064, 43706, 51348, 58990 anti-influenza_Chain 5497 13139, 20781,28423, 36065, 43707, 51349, 58991 anti-influenza_Chain 5498 13140,20782, 28424, 36066, 43708, 51350, 58992 anti-influenza_Chain 549913141, 20783, 28425, 36067, 43709, 51351, 58993 anti-influenza_Chain5500 13142, 20784, 28426, 36068, 43710, 51352, 58994anti-influenza_Chain 5501 13143, 20785, 28427, 36069, 43711, 51353,58995 anti-influenza_Chain 5502 13144, 20786, 28428, 36070, 43712,51354, 58996 anti-influenza_Chain 5503 13145, 20787, 28429, 36071,43713, 51355, 58997 anti-influenza_Chain 5504 13146, 20788, 28430,36072, 43714, 51356, 58998 anti-influenza_Chain 5505 13147, 20789,28431, 36073, 43715, 51357, 58999 anti-influenza_Chain 5506 13148,20790, 28432, 36074, 43716, 51358, 59000 anti-influenza_Chain 550713149, 20791, 28433, 36075, 43717, 51359, 59001 anti-influenza_Chain5508 13150, 20792, 28434, 36076, 43718, 51360, 59002anti-influenza_Chain 5509 13151, 20793, 28435, 36077, 43719, 51361,59003 anti-influenza_Chain 5510 13152, 20794, 28436, 36078, 43720,51362, 59004 anti-influenza_Chain 5511 13153, 20795, 28437, 36079,43721, 51363, 59005 anti-influenza_Chain 5512 13154, 20796, 28438,36080, 43722, 51364, 59006 anti-influenza_Chain 5513 13155, 20797,28439, 36081, 43723, 51365, 59007 anti-influenza_Chain 5514 13156,20798, 28440, 36082, 43724, 51366, 59008 anti-influenza_Chain 551513157, 20799, 28441, 36083, 43725, 51367, 59009 anti-influenza_Chain5516 13158, 20800, 28442, 36084, 43726, 51368, 59010anti-influenza_Chain 5517 13159, 20801, 28443, 36085, 43727, 51369,59011 anti-influenza_Chain 5518 13160, 20802, 28444, 36086, 43728,51370, 59012 anti-influenza_Chain 5519 13161, 20803, 28445, 36087,43729, 51371, 59013 anti-influenza_Chain 5520 13162, 20804, 28446,36088, 43730, 51372, 59014 anti-influenza_Chain 5521 13163, 20805,28447, 36089, 43731, 51373, 59015 anti-influenza_Chain 5522 13164,20806, 28448, 36090, 43732, 51374, 59016 anti-influenza_Chain 552313165, 20807, 28449, 36091, 43733, 51375, 59017 anti-influenza_Chain5524 13166, 20808, 28450, 36092, 43734, 51376, 59018anti-influenza_Chain 5525 13167, 20809, 28451, 36093, 43735, 51377,59019 anti-influenza_Chain 5526 13168, 20810, 28452, 36094, 43736,51378, 59020 anti-influenza_Chain 5527 13169, 20811, 28453, 36095,43737, 51379, 59021 anti-influenza_Chain 5528 13170, 20812, 28454,36096, 43738, 51380, 59022 anti-influenza_Chain 5529 13171, 20813,28455, 36097, 43739, 51381, 59023 anti-influenza_Chain 5530 13172,20814, 28456, 36098, 43740, 51382, 59024 anti-influenza_Chain 553113173, 20815, 28457, 36099, 43741, 51383, 59025 anti-influenza_Chain5532 13174, 20816, 28458, 36100, 43742, 51384, 59026anti-influenza_Chain 5533 13175, 20817, 28459, 36101, 43743, 51385,59027 anti-influenza_Chain 5534 13176, 20818, 28460, 36102, 43744,51386, 59028 anti-influenza_Chain 5535 13177, 20819, 28461, 36103,43745, 51387, 59029 anti-influenza_Chain 5536 13178, 20820, 28462,36104, 43746, 51388, 59030 anti-influenza_Chain 5537 13179, 20821,28463, 36105, 43747, 51389, 59031 anti-influenza_Chain 5538 13180,20822, 28464, 36106, 43748, 51390, 59032 anti-influenza_Chain 553913181, 20823, 28465, 36107, 43749, 51391, 59033 anti-0X40_LightChain5540 13182, 20824, 28466, 36108, 43750, 51392, 59034anti-0X40_LightChain 5541 13183, 20825, 28467, 36109, 43751, 51393,59035 anti-0X40_LightChain 5542 13184, 20826, 28468, 36110, 43752,51394, 59036 anti-0X40_LightChain 5543 13185, 20827, 28469, 36111,43753, 51395, 59037 anti-0X40_LightChain 5544 13186, 20828, 28470,36112, 43754, 51396, 59038 anti-0X40_LightChain 5545 13187, 20829,28471, 36113, 43755, 51397, 59039 anti-0X40_LightChain 5546 13188,20830, 28472, 36114, 43756, 51398, 59040 anti-0X40_LightChain 554713189, 20831, 28473, 36115, 43757, 51399, 59041 anti-0X40_LightChain5548 13190, 20832, 28474, 36116, 43758, 51400, 59042anti-0X40_LightChain 5549 13191, 20833, 28475, 36117, 43759, 51401,59043 anti-0X40_LightChain 5550 13192, 20834, 28476, 36118, 43760,51402, 59044 anti-0X40_LightChain 5551 13193, 20835, 28477, 36119,43761, 51403, 59045 anti-0X40_LightChain 5552 13194, 20836, 28478,36120, 43762, 51404, 59046 anti-0X40_LightChain 5553 13195, 20837,28479, 36121, 43763, 51405, 59047 anti-0X40_HeavyChain 5554 13196,20838, 28480, 36122, 43764, 51406, 59048 anti-0X40_HeavyChain 555513197, 20839, 28481, 36123, 43765, 51407, 59049 anti-0X40_HeavyChain5556 13198, 20840, 28482, 36124, 43766, 51408, 59050anti-0X40_HeavyChain 5557 13199, 20841, 28483, 36125, 43767, 51409,59051 anti-0X40_HeavyChain 5558 13200, 20842, 28484, 36126, 43768,51410, 59052 anti-0X40_HeavyChain 5559 13201, 20843, 28485, 36127,43769, 51411, 59053 anti-0X40_HeavyChain 5560 13202, 20844, 28486,36128, 43770, 51412, 59054 anti-0X40_HeavyChain 5561 13203, 20845,28487, 36129, 43771, 51413, 59055 anti-0X40_HeavyChain 5562 13204,20846, 28488, 36130, 43772, 51414, 59056 anti-0X40_HeavyChain 556313205, 20847, 28489, 36131, 43773, 51415, 59057 anti-0X40_HeavyChain5564 13206, 20848, 28490, 36132, 43774, 51416, 59058anti-0X40_HeavyChain 5565 13207, 20849, 28491, 36133, 43775, 51417,59059 anti-0X40_HeavyChain 5566 13208, 20850, 28492, 36134, 43776,51418, 59060 anti-0X40_HeavyChain 5567 13209, 20851, 28493, 36135,43777, 51419, 59061 anti-0X40_HeavyChain 5568 13210, 20852, 28494,36136, 43778, 51420, 59062 anti-0X40_HeavyChain 5569 13211, 20853,28495, 36137, 43779, 51421, 59063 anti-0X40_HeavyChain 5570 13212,20854, 28496, 36138, 43780, 51422, 59064 anti-0X40_HeavyChain 557113213, 20855, 28497, 36139, 43781, 51423, 59065 anti-0X40_HeavyChain5572 13214, 20856, 28498, 36140, 43782, 51424, 59066anti-0X40_HeavyChain 5573 13215, 20857, 28499, 36141, 43783, 51425,59067 anti-0X40_HeavyChain 5574 13216, 20858, 28500, 36142, 43784,51426, 59068 anti-0X40_HeavyChain 5575 13217, 20859, 28501, 36143,43785, 51427, 59069 anti-0X40_HeavyChain 5576 13218, 20860, 28502,36144, 43786, 51428, 59070 anti-0X40_HeavyChain 5577 13219, 20861,28503, 36145, 43787, 51429, 59071 anti-0X40_HeavyChain 5578 13220,20862, 28504, 36146, 43788, 51430, 59072 anti-0X40_HeavyChain 557913221, 20863, 28505, 36147, 43789, 51431, 59073 anti-0X40_HeavyChain5580 13222, 20864, 28506, 36148, 43790, 51432, 59074anti-0X40_HeavyChain 5581 13223, 20865, 28507, 36149, 43791, 51433,59075 anti-0X40_HeavyChain 5582 13224, 20866, 28508, 36150, 43792,51434, 59076 anti-0X40_HeavyChain 5583 13225, 20867, 28509, 36151,43793, 51435, 59077 anti-0X40_HeavyChain 5584 13226, 20868, 28510,36152, 43794, 51436, 59078 anti-0X40_HeavyChain 5585 13227, 20869,28511, 36153, 43795, 51437, 59079 anti-0X40_HeavyChain 5586 13228,20870, 28512, 36154, 43796, 51438, 59080 anti-0X40_HeavyChain 558713229, 20871, 28513, 36155, 43797, 51439, 59081 anti-0X40_HeavyChain5588 13230, 20872, 28514, 36156, 43798, 51440, 59082anti-0X40_LightChain 5589 13231, 20873, 28515, 36157, 43799, 51441,59083 anti-0X40_LightChain 5590 13232, 20874, 28516, 36158, 43800,51442, 59084 anti-0X40_LightChain 5591 13233, 20875, 28517, 36159,43801, 51443, 59085 anti-0X40_LightChain 5592 13234, 20876, 28518,36160, 43802, 51444, 59086 anti-0X40_LightChain 5593 13235, 20877,28519, 36161, 43803, 51445, 59087 anti-0X40_HeavyChain 5594 13236,20878, 28520, 36162, 43804, 51446, 59088 anti-0X40_HeavyChain 559513237, 20879, 28521, 36163, 43805, 51447, 59089 anti-0X40_HeavyChain5596 13238, 20880, 28522, 36164, 43806, 51448, 59090anti-0X40_HeavyChain 5597 13239, 20881, 28523, 36165, 43807, 51449,59091 anti-0X40_HeavyChain 5598 13240, 20882, 28524, 36166, 43808,51450, 59092 anti-0X40_LightChain 5599 13241, 20883, 28525, 36167,43809, 51451, 59093 anti-0X40_HeavyChain 5600 13242, 20884, 28526,36168, 43810, 51452, 59094

In a preferred embodiment the at least one coding sequence of the RNAaccording to the present invention encodes an antibody, i.e. inparticular a full length (“complete”) antibody. In other words, it ispreferred that a full length (“complete”) antibody is encoded by asingle RNA (molecule). This may be realized by a monocistronic RNA(wherein heavy and light chain or fragments thereof such as therespective variable regions may, for example, be connected via apeptidic linker) or by a bi- or multicistronic RNA, wherein differentfragments of the antibody, such as the heavy chain (or a fragmentthereof, e.g. the heavy chain variable region) and the light chain (or afragment thereof, e.g. the light chain variable region), are encoded inseparate cistrons as described herein. It is also preferred that the atleast one coding sequence of the RNA according to the present inventionencodes a fragment of an antibody only, such as the heavy chain (or afragment thereof, e.g. the heavy chain variable region) or the lightchain (or a fragment thereof, e.g. the light chain variable region),with the corresponding fragment(s) required for a functional antibodybeing encoded by another RNA (molecule) according to the presentinvention.

For example, for the antibody abagovomab, the RNA according to thepresent invention may encode

-   (i) the heavy chain (amino acid sequence according to SEQ ID NO: 2),    for example by an RNA sequence according to any of SEQ ID NOs: 7644,    15286, 22928, 30570, 38212, 45854, 53496, or a fragment or variant    thereof; and-   (ii) the light chain (amino acid sequence according to SEQ ID NO:    3), for example by an RNA sequence according to any of SEQ ID NOs:    7645, 15287, 22929, 30571, 38213, 45855, 53497, or a fragment or    variant thereof    in a monocistronic (e.g., connected by a peptide linker) or in a    multicistronic, in particular bicistronic, manner as described    herein. Alternatively, the RNA according to the present invention    may encode the heavy chain (amino acid sequence according to SEQ ID    NO: 2), for example by an RNA sequence according to any of SEQ ID    NOs: 7644, 15286, 22928, 30570, 38212, 45854, 53496, or a fragment    or variant thereof, only and the corresponding light chain (amino    acid sequence according to SEQ ID NO: 3), for example by an RNA    sequence according to any of SEQ ID NOs: 7645, 15287, 22929, 30571,    38213, 45855, 53497, ora fragment or variant thereof, may be encoded    by a separate RNA (molecule). The latter option applies in    particular in the context of a combination according to the present    invention as described herein and of certain embodiments of the    composition and of the kit as described herein. In summary, by all    of the above options RNA encoding a (functional) antibody abagovomab    can be provided. Other antibodies may be provided in a similar    manner based on the information, which can be retrieved from Table    3.

Preferably, the at least one coding sequence of the RNA according to thepresent invention encodes an antibody or a fragment or variant thereof,in particular an antigen-binding fragment or variant thereof, asdescribed above.

More preferably, the at least one coding sequence of the RNA accordingto the present invention encodes a heavy chain and/or a light chain ofan antibody, or a fragment or variant of a heavy chain and/or of a lightchain of an antibody, in particular an antigen-binding fragment orvariant of a heavy chain and/or of a light chain of an antibody.

Even more preferably, the at least one coding sequence of the RNAaccording to the present invention encodes a heavy chain variable regionand/or a light chain variable region of an antibody, or anantigen-binding fragment or variant of a heavy chain variable regionand/or a light chain variable region of an antibody.

Table 4 below shows the amino acid positions of the heavy chain variableregion and of the light chain variable region as well as of the heavychain constant region and of the light chain constant region in theheavy chain and light chain amino acid sequences of exemplifiedantibodies, respectively. Those sequences of the heavy chain variableregion and of the light chain variable region as well as of the heavychain constant region and of the light chain constant region arepreferably encoded by the RNA according to the present invention asdescribed herein. In Table 4 a variable region of, for example, “1-119”means that amino acids 1-119 of the respective amino acid sequence(“Protein SEQ ID NO”) form the variable region. The first columnidentifies whether the amino acid sequence (“Protein SEQ ID NO”) is ofthe heavy chain or of the light chain. Accordingly, the skilled personcan easily identify the heavy chain variable region, the light chainvariable region as well as the heavy chain constant region and the lightchain constant region of the exemplified antibodies based on theinformation in Table 4. Moreover, on basis of that information on aminoacid sequence level, the skilled person can easily identify thecorresponding RNA sequence fragments (i.e. the RNA sequences encodingthe heavy chain/light chain constant region/variable regionrespectively), in particular by using the RNA sequences shown in Table 3corresponding to the antibody of interest's amino acid sequence.

TABLE 4 Variable regions and constant regions of exemplified antibodiesProtein SEQ ID Name NO Variable Region Constant RegionAAB-003_gamma1-Chain 1 1-119 120-449 Abagovomab_HeavyChain 2 1-119120-443 Abagovomab_LightChain 3 1-107 108-214 Abciximab_HeavyChain 41-119 120-450 Abciximab_LightChain 5 1-107 108-214Abituzumab_HeavyChain1 6 1-118 119-447 Abituzumab_LightChain1 7 1-107108-214 Abrilumab_HeavyChain1 8 1-118 119-444 Abrilumab_LightChain1 91-107 108-214 Abrilumab_LightChain1_variant2 10 1-106 107-213Actoxumab_HeavyChain1 11 1-119 120-449 Actoxumab_LightChain1 12 1-108109-215 Adalimumab_HeavyChain 13 1-121 122-224 Adalimumab_LightChain 141-107 108-214 Aducanumab_HeavyChain1 15 1-124 125-453Aducanumab_LightChain1 16 1-107 108-214 Afasevikumab_HeavyChain1 171-123 124-453 Afasevikumab_LightChain1 18 1-108 109-215Aflibercept_Fusion_protein1 19 1-120 121-431 Afutuzuab_HeavyChain1 201-117 118-444 Afutuzuab_LightChain1 21 1-110 111-217Afutuzumab_HeavyChain1 22 1-119 120-449 Afutuzumab_LightChain1 23 1-112113-219 Alacizumab_pegal_HeavyChain1 24 1-115 116-228Alacizumab_pegal_LightChain1 25 1-107 108-214 Alemtuzumab_HeavyChain 261-121 122-451 Alemtuzumab_HeavyChain_variant_Ibey_H 27 1-121 122-219Alemtuzumab_HeavyChain_variant_Icel_H 28 1-121 122-220Alemtuzumab_HeavyChain_variant_8005_H 29 1-121 122-437Alemtuzumab_LightChain 30 1-107 108-211Alemtuzumab_LightChain_variant_8005_L 31 1-107 108-214Alirucumab_HeavyChain1 32 1-118 119-447 Alirucumab_LightChain1 33 1-113114-220 ALX-0061_HeavyChain1 34 1-121 122-245 Amatuximab_HeavyChain1 351-119 120-449 Amatuximab_LightChain1 36 1-106 107-213Anetumab_ravtansine_HeavyChain1 37 1-120 121-450Anetumab_ravtansine_LightChain1 38 1-111 112-217 Anifrolumab_HeavyChain139 1-117 118-447 Anifrolumab_LightChain1 40 1-108 109-215Anrukinzumab_HeavyChain1 41 1-118 119-448 Anrukinzumab_LightChain1 421-111 112-218 Apolizumab_HeavyChain1 43 1-107 108-214Apolizumab_LightChain1 44 1-116 117-446 Apomab_HeavyChain 45 1-120121-126 Apomab_LightChain 46 1-108 109-108 Aquaporumab_LightChain 471-108 109-215 Arcitumomab_99tc_HeavyChain 48 1-121 122-442Arcitumomab_99tc_LightChain 49 1-106 107-213 Ascrinvacumab_HeavyChain150 1-118 119-443 Ascrinvacumab_LightChain1 51 1-108 109-215Aselizuab_HeavyChain1 52 1-114 115-438 Aselizuab_HeavyChain2 53 1-114115-437 Aselizuab_LightChain1 54 1-109 110-216 Atezolizumab_HeavyChain155 1-118 119-448 Atezolizumab_LightChain1 56 1-107 108-214Atinumab_HeavyChain1 57 1-114 115-441 Atinumab_LightChain1 58 1-107108-214 Atlizuab_HeavyChain1 59 1-116 117-443 Atlizuab_LightChain1 601-106 107-213 Aurograb_SingleChain 61 1-123 124-264 Avelumab_HeavyChain162 1-120 121-450 Avelumab_LightChain1 63 1-110 111-216Bapineuzumab_HeavyChain1 64 1-112 113-219 Bapineuzumab_LightChain1 651-119 120-448 Basiliximab_HeavyChain 66 1-115 116-446Basiliximab_LightChain 67 1-104 105-210 Bavituximab_HeavyChain 68 1-120121-456 Bavituximab_LightChain 69 1-107 108-214Bavituximab_LightChain_variant_8734_L 70 1-107 108-208Begelomab_HeavyChain1 71 1-120 121-459 Begelomab_LightChain1 72 1-106107-213 Benralizumab_HeavyChain1 73 1-121 122-451Benralizumab_LightChain1 74 1-107 108-214 Betalutin_HeavyChain1 75 1-107108-214 Betalutin_LightChain1 76 1-119 120-443 Bevacituzuab_HeavyChain177 1-121 122-448 Bevacituzuab_LightChain1 78 1-106 107-213Bevacizumab_154-aspartin_acid_LightChain 79 1-107 108-213Bevacizumab_154-substitution_deriv_LightChain 80 1-107 108-213Bevacizumab_180-serine_HeavyChain 81 1-123 124-224Bevacizumab_180-substitution_deriv_HeavyChain 82 1-123 124-224Bevacizumab_beta_HeavyChain1 83 1-123 124-453Bevacizumab_beta_LightChain1 84 1-107 108-214 Bevacizumab_FcDomain 851-120 121-229 Bevacizumab_HeavyChain 86 1-123 124-224Bevacizumab_HeavyChain_variant1 87 1-112 113-476Bevacizumab_HeavyChain_V-Region 88 1-123 124-123 Bevacizumab_LightChain189 1-132 133-239 Bevacizumab_LightChain2 90 1-130 131-237Bevacizumab_LightChain 91 1-107 108-214 Bevacizumab_LightChain_VJ-Region92 1-107 108-108 Bevacizumab_LightChain_V-Region 93 1-107 108-107Bevacizumab-rhuMAb-VEGF_HeavyChain_gamma1-Chain_VDJ- 94 1-123 124-123Region Bevacizumab-rhuMAb-VEGF_LightChain_VJ-Region 95 1-107 108-107Bevacizumab_gamma1-Chain 96 1-123 124-447Bevacizumab_gamma1-Chain_CH3-Region_mutein 97 1-123 124-453Bezlotuxumab_HeavyChain1 98 1-119 120-449 Bezlotuxumab_LightChain1 991-108 109-215 Bimagrumab_HeavyChain1 100 1-115 116-445Bimagrumab_HeavyChain 101 1-115 116-444 Bimagrumab_LightChain1 102 1-111112-217 Bimekizumab_HeavyChain1 103 1-125 126-455Bimekizumab_LightChain1 104 1-107 108-214 Bleselumab_HeavyChain1 1051-121 122-448 Bleselumab_LightChain1 106 1-106 107-213Blinatumomab_HeavyChain1 107 1-111 112-504 Blinatumomab_SingleChain 1081-111 112-505Blinatumomab_SingleChain_variable_fragment_fusion_protein_(bite) 1091-111 112-504 Blontuvetmab_HeavyChain 110 1-113 114-448Blontuvetmab_LightChain 111 1-113 114-219 Blosozumab_HeavyChain1 1121-118 119-444 Blosozumab_LightChain1 113 1-107 108-214Bococizumab_HeavyChain1 114 1-118 119-444 Bococizumab_LightChain1 1151-107 108-214 Brentuximab_vedutin_HeavyChain1 116 1-117 118-446Brentuximab_vedutin_LightChain1 117 1-111 112-218Briakinumab_HeavyChain1 118 1-115 116-445 Briakinumab_LightChain1 1191-111 112-217 Brodalumab_HeavyChain1 120 1-116 117-442Brodalumab_LightChain1 121 1-107 108-214 Brolucizumab_HeavyChain1 1221-110 111-252 Brolucizumab_scfv_fragment 123 1-110 111-252Bruntictuzumab_HeavyChain1 124 1-121 122-447 Bruntictuzumab_LightChain1125 1-109 110-215 BTT-1023_HeavyChain1 126 1-117 118-444BTT-1023_LightChain1 127 1-107 108-214 Burosumab_HeavyChain1 128 1-106107-213 Burosumab_LightChain1 129 1-117 118-447 Canakinumab_HeavyChain1130 1-119 120-455 Canakinumab_HeavyChain 131 1-118 119-448Canakinumab_LightChain1 132 1-108 109-217 Canakinumab_LightChain 1331-107 108-214 Canakinumab_LightChain_variant_8836_L 134 1-118 119-394Cantuzumab_HeavyChain1 135 1-69   70-399 Cantuzumab_HeavyChain 136 1-119120-449 Cantuzumab_LightChain1 137 1-112 113-219Cantuzumab_mertansine_HeavyChain1 138 1-112 113-219Cantuzumab_mertansine_LightChain1 139 1-119 120-448Cantuzumab_ravtansine_HeavyChain1 140 1-119 120-449Cantuzumab_ravtansine_LightChain1 141 1-112 113-219 Caplacizumab 1421-120 121-259 Caplacizumab_HeavyChain1 143 1-120 121-259Caplacizumab_HeavyChain1 144 1-120 121-259 Carlumab_HeavyChain1 1451-119 120-449 Carlumab_LightChain1 146 1-109 110-216Cergutuzumab_amunaleukin_HeavyChain1 147 1-121 122-451Cergutuzumab_amunaleukin_HeavyChain2 148 1-121 122-599Cergutuzumab_amunaleukin_LightChain1 149 1-108 109-215Certolizumab_pegol_HeavyChain1 150 1-118 119-229Certolizumab_pegol_HeavyChain 151 1-107 108-214Certolizumab_pegol_LightChain1 152 1-107 108-214Certolizumab_pegol_LightChain 153 1-118 119-229 Cetuximab_HeavyChain 1541-119 120-452 Cetuximab_HeavyChain_variant 155 1-119 120-449Cetuximab_LightChain 156 1-107 108-213 Cetuximab_LightChain_variant 1571-107 108-214 Citatuzumab_bogatox_HeavyChain1 158 1-122 123-225Citatuzumab_bogatox_LightChain1 159 1-112 113-481Cixutumumab_HeavyChain1 160 1-130 131-460 Cixutumumab_LightChain1 1611-108 109-214 Clazakizumab_HeavyChain1 162 1-120 121-450Clazakizumab_LightChain1 163 1-110 111-217Clivatuzumab_tetraxetan_HeavyChain1 164 1-119 120-449Clivatuzumab_tetraxetan_LightChain1 165 1-108 108-215Codrituzumab_HeavyChain1 166 1-115 116-445 Codrituzumab_LightChain1 1671-112 113-216 Coltuximab_ravtansine_HeavyChain1 168 1-120 121-450Coltuximab_ravtansine_LightChain1 169 1-104 105-211Conatumumab_CV_HeavyChain 170 1-123 124-458 Conatumumab_CV_LightChain171 1-109 110-218 Conatumumab_HeavyChain1 172 1-122 123-452Conatumumab_HeavyChain 173 1-122 123-452 Conatumumab_LightChain1 1741-108 109-215 Conatumumab_LightChain 175 1-108 109-215Concizumab_HeavyChain1 176 1-121 122-448 Concizumab_LightChain1 1771-112 113-219 Crenezumab_HeavyChain1 178 1-112 113-438Crenezumab_LightChain1 179 1-112 113-219 Crotedumab_HeavyChain1 1801-107 108-214 Crotedumab_HeavyChain2 181 1-107 109-214Crotedumab_LightChain1 182 1-128 129-455 Crotedumab_LightChain2 1831-128 129-455 Dacetuzumab_HeavyChain1 184 1-114 115-444Dacetuzumab_LightChain1 185 1-112 113-219Dacliximab_LightChain_VJ-Region 186 1-106 107-106Dacliximab_gamma2-Chain_VDJ-Region 187 1-116 117-116Daclizumab_HeavyChain 188 1-116 117-442 Daclizumab_LightChain 189 1-106107-210 Dalotuzumab_HeavyChain1 190 1-117 118-447Dalotuzumab_LightChain1 191 1-112 113-219Dapirolizumab_pegol_HeavyChain1 192 1-118 119-229Dapirolizumab_pegol_LightChain1 193 1-107 108-214Daratumumab_HeavyChain1 194 1-122 123-452 Daratumumab_LightChain1 1951-107 108-214 Dectrekumab_HeavyChain1 196 1-120 121-450Dectrekumab_LightChain1 197 1-109 110-216 Demcizumab_HeavyChain1 1981-119 120-444 Demcizumab_LightChain1 199 1-111 112-218Denintuzumab_mafodotin_HeavyChain1 200 1-120 121-450Denintuzumab_mafodotin_LightChain1 201 1-106 107-213Denosumab_HeavyChain 202 1-122 123-452 Denosumab_LightChain 203 1-108109-215 Depatuxizumab_HeavyChain1 204 1-107 108-214Depatuxizumab_LightChain1 205 1-116 117-446Depatuxizumab_mafodotin_HeavyChain1 206 1-107 108-214Depatuxizumab_mafodotin_LightChain1 207 1-116 117-446Dinutuximab_beta_HeavyChain1 208 1-113 114-443Dinutuximab_beta_LightChain1 209 1-113 114-221 Dinutuximab_HeavyChain1210 1-113 114-443 Dinutuximab_LightChain1 211 1-113 114-221Dinutuximab_LightChain 212 1-113 114-220 Diridavumab_HeavyChain1 2131-121 122-450 Diridavumab_LightChain1 214 1-111 112-217Domagrozumab_HeavyChain1 215 1-116 117-446 Domagrozumab_HeavyChain 2161-116 117-445 Domagrozumab_LightChain1 217 1-107 108-214Drozituab_HeavyChain1 218 1-119 120-445 Drozituab_LightChain1 219 1-107108-213 Drozitumab_HeavyChain1 220 1-121 122-451 Drozitumab_LightChain1221 1-107 108-213 Duligotumab_HeavyChain1 222 1-121 122-451Duligotumab_LightChain1 223 1-107 108-214 Duligotuzumab_HeavyChain1 2241-121 122-451 Duligotuzumab_LightChain1 225 1-107 108-214Dupilumab_HeavyChain1 226 1-125 126-451 Dupilumab_LightChain1 227 1-112113-219 Durvalumab_HeavyChain1 228 1-121 122-451 Durvalumab_LightChain1229 1-108 109-215 Dusigitumab_HeavyChain1 230 1-120 121-446Dusigitumab_LightChain1 231 1-111 112-217 Ecromeximab_HeavyChain1 2321-107 108-214 Ecromeximab_LightChain1 233 1-119 120-449Eculizumab_HeavyChain1 234 1-107 108-214 Eculizumab_LightChain1 2351-121 122-447 Efalizumab_HeavyChain 236 1-125 126-125Efalizumab_LightChain 237 1-108 109-108Efungumab_SingleChain_variable_fragment 238 1-122 123-256Eldelumab_HeavyChain1 239 1-124 125-454 Eldelumab_LightChain1 240 1-109110-216 Elgemtumab_HeavyChain1 241 1-117 118-447 Elgemtumab_LightChain1242 1-107 108-214 Elotuzumab_HeavyChain1 243 1-119 120-449Elotuzumab_LightChain1 244 1-107 108-214 Emactuzumab_HeavyChain1 2451-116 117-446 Emactuzumab_LightChain1 246 1-106 107-213Emibetuzumab_HeavyChain1 247 1-115 116-441 Emibetuzumab_LightChain1 2481-108 109-215 Emicizumab_HeavyChain1 249 1-123 124-448Emicizumab_HeavyChain2 250 1-119 120-444 Emicizumab_LightChain1 2511-107 108-214 Enavatuzumab_HeavyChain1 252 1-119 120-449Enavatuzumab_LightChain1 253 1-111 112-218 Enfortumab_HeavyChain 2541-117 118-447 Enfortumab_LightChain 255 1-107 108-214Enfortumab_vedotin_HeavyChain1 256 1-117 118-447Enfortumab_vedotin_LightChain1 257 1-107 108-214Enoblituzumab_HeavyChain 258 1-122 123-452 Enoblituzumab_LightChain 2591-107 108-214 Enokizumab_HeavyChain1 260 1-122 123-452Enokizumab_LightChain1 261 1-107 108-214 Enokizumab_LightChain 262 1-107108-204 Enoticumab_HeavyChain1 263 1-123 124-452 Enoticumab_LightChain1264 1-107 108-214 Ensituximab_HeavyChain1 265 1-113 114-443Ensituximab_LightChain1 266 1-166 107-213Ensituximab_SingleChain_variable_fragment 267 1-122 123-256Entolimod_chain1 268 1-120 121-329 Epratuzumab_HeavyChain 269 1-116117-446 Epratuzumab_LightChain 270 1-112 113-219Eptacog_beta_HeavyChain1 271 1-120 121-255 Eptacog_beta_LightChain1 2721-107 108-152 Erlizuab_HeavyChain1 273 1-119 120-236Erlizuab_LightChain1 274 1-106 107-213 Etaracizumab_HeavyChain1 2751-117 118-447 Etaracizumab_LightChain1 276 1-107 108-214Etrolizuab_HeavyChain1 277 1-116 117-442 Etrolizuab_HeavyChain2 2781-116 117-442 Etrolizuab_LightChain1 279 1-106 107-213Etrolizumab_HeavyChain1 280 1-117 118-446 Etrolizumab_LightChain1 2811-107 108-214 Evinacumab_HeavyChain1 282 1-126 127-453Evinacumab_LightChain1 283 1-107 108-214 Evolocumab_HeavyChain1 2841-115 116-441 Evolocumab_LightChain1 285 1-109 110-215Exbivirumab_HeavyChain1 286 1-121 122-451 Exbivirumab_LightChain1 2871-108 109-214 Farletuzumab_HeavyChain1 288 1-119 120-449Farletuzumab_LightChain1 289 1-110 111-217 Fasinumab_HeavyChain1 2901-119 120-446 Fasinumab_LightChain1 291 1-107 108-214Fezakinumab_HeavyChain1 292 1-121 122-450 Fezakinumab_LightChain1 2931-111 112-217 FG-3019_HeavyChain1 294 1-107 108-214 FG-3019_LightChain1295 1-120 121-449 Fibatuzumab_HeavyChain1 296 1-118 119-448Fibatuzumab_LightChain1 297 1-107 108-214 Ficlatuzumab_HeavyChain1 2981-118 119-448 Ficlatuzumab_HeavyChain 299 1-117 118-447Ficlatuzumab_LightChain1 300 1-107 108-214 Figitumumab_HeavyChain1 3011-125 126-450 Figitumumab_LightChain1 302 1-107 108-214Firivumab_HeavyChain1 303 1-123 124-453 Firivumab_LightChain1 304 1-107108-214 Flanvotumab_HeavyChain1 305 1-119 120-449Flanvotumab_LightChain1 306 1-108 109-215 Fletikumab_HeavyChain1 3071-127 128-454 Fletikumab_LightChain1 308 1-107 108-214Fontolizumab_HeavyChain1 309 1-107 108-214 Fontolizumab_LightChain1 3101-117 118-447 Foralumab_HeavyChain1 311 1-118 119-448Foralumab_LightChain1 312 1-108 109-215 Foravirumab_HeavyChain1 3131-119 120-448 Foravirumab_HeavyChain 314 1-119 120-448Foravirumab_LightChain1 315 1-107 108-214 Fresolimumab_HeavyChain1 3161-120 121-447 Fresolimumab_LightChain1 317 1-108 109-215Fulranumab_HeavyChain1 318 1-123 124-449 Fulranumab_LightChain1 3191-107 108-214 Futuximab_HeavyChain1 320 1-123 124-452Futuximab_LightChain1 321 1-107 108-214 Galcanezumab_HeavyChain1 3221-119 120-445 Galcanezumab_LightChain1 323 1-107 108-214Galiximab_HeavyChain1 324 1-110 111-216 Galiximab_LightChain1 325 1-127128-457 Ganitumab_HeavyChain1 326 1-119 120-449 Ganitumab_LightChain1327 1-112 113-219 Gantenerumab_HeavyChain1 328 1-126 127-456Gantenerumab_LightChain1 329 1-108 109-215 Gemtuzumab_HeavyChain1 3301-116 117-116 Gemtuzumab_HeavyChain2 331 1-117 118-117Gemtuzumab_LightChain2 332 1-107 108-107Gemtuzumab_ozogamicin_LightChain1 333 1-106 107-106Gevokizumab_HeavyChain1 334 1-120 121-445 Gevokizumab_LightChain1 3351-107 108-214 Girentuximab_HeavyChain1 336 1-119 120-449Girentuximab_LightChain1 337 1-107 108-214 Glembatumumab_HeavyChain1 3381-119 120-445 Glembatumumab_LightChain1 339 1-108 109-215Goilixiab_HeavyChain1 340 1-116 117-444 Goilixiab_LightChain1 341 1-106107-213 Guselkumab_HeavyChain1 342 1-117 118-446 Guselkumab_LightChain1343 1-111 112-217 HuMab-001_HeavyChain_VDJ-Region 344 1-120 121-120HuMab-001_LightChain_VJ-Region 345 1-107 108-107HuMab-005_HeavyChain_gamma-Chain_VDJ-Region 346 1-122 123-122HuMab-005_LightChain_VJ-Region 347 1-107 108-107HuMab-006_HeavyChain_VDJ-Region 348 1-119 120-119HuMab-006_LightChain_VJ-Region 349 1-108 109-108HuMab-019_HeavyChain_VDJ-Region 350 1-120 121-120HuMab-021_HeavyChain_VDJ-Region 351 1-120 121-120HuMab-021_LightChain_VJ-Region 352 1-107 108-107HuMab-025_HeavyChain_VDJ-Region 353 1-120 121-120HuMab-025_LightChain_VJ-Region 354 1-107 108-107HuMab-027_HeavyChain_VDJ-Region 355 1-120 121-120HuMab-032_HeavyChain_VDJ-Region 356 1-120 121-120HuMab-032_LightChain_VJ-Region 357 1-107 108-107HuMab-033_HeavyChain_VDJ-Region 358 1-121 122-121HuMab-035_HeavyChain_VDJ-Region 359 1-120 121-120HuMab-036_HeavyChain_VDJ-Region 360 1-120 121-120HuMab-036_LightChain_VJ-Region 361 1-107 108-107HuMab-041_HeavyChain_VDJ-Region 362 1-122 123-122HuMab-044_HeavyChain_VDJ-Region 363 1-122 123-122HuMab-049_HeavyChain_VDJ-Region 364 1-119 120-119HuMab-049_LightChain_VJ-Region 365 1-107 108-107HuMab-050_HeavyChain_VDJ-Region 366 1-119 120-119HuMab-050_LightChain_VJ-Region 367 1-107 108-107HuMab-054_HeavyChain_VDJ-Region 368 1-120 121-120HuMab-054_LightChain_VJ-Region 369 1-107 108-107HuMab-055_HeavyChain_VDJ-Region 370 1-119 120-119HuMab-059_HeavyChain_VDJ-Region 371 1-122 123-122HuMab-059_LightChain_VJ-Region 372 1-108 109-108HuMab-060_HeavyChain_VDJ-Region 373 1-122 123-122HuMab-060_LightChain_VJ-Region 374 1-109 110-109HuMab-067_HeavyChain_VDJ-Region 375 1-122 123-122HuMab-072_HeavyChain_VDJ-Region 376 1-122 123-122HuMab-072_LightChain_VJ-Region 377 1-109 110-109HuMab-084_HeavyChain_VDJ-Region 378 1-121 122-121HuMab-084_LightChain_VJ-Region 379 1-107 108-107HuMab-091_HeavyChain_VDJ-Region 380 1-120 121-120HuMab-091_LightChain_VJ-Region 381 1-107 108-107HuMab-093_HeavyChain_VDJ-Region 382 1-122 123-122HuMab-098_HeavyChain_VDJ-Region 383 1-124 125-124HuMab-098_LightChain_VJ-Region 384 1-107 108-107HuMab-100_HeavyChain_VDJ-Region 385 1-124 125-124HuMab-106_HeavyChain_VDJ-Region 386 1-124 125-124HuMab-106_LightChain_VJ-Region 387 1-107 108-107HuMab_10F8_HeavyChain_V-Region 388 1-117 118-117HuMab_10F8_HeavyChain_V-Region_Precursor 389 1-136 137-136HuMab_10F8_LightChain_V-Region 390 1-107 108-107HuMab_10F8_LightChain_V-Region_Precursor 391 1-127 128-127HuMab-111_HeavyChain_VDJ-Region 392 1-119 120-119HuMab-111_LightChain_VJ-Region 393 1-107 108-107HuMab-123_HeavyChain_VDJ-Region 394 1-121 122-121HuMab-123_LightChain_VJ-Region 395 1-107 108-107HuMab-124_HeavyChain_VDJ-Region 396 1-121 122-121HuMab-125_HeavyChain_VDJ-Region 397 1-124 125-124HuMab-125_LightChain_VJ-Region 398 1-107 108-107HuMab-127_HeavyChain_VDJ-Region 399 1-123 124-123HuMab-127_LightChain_VJ-Region 400 1-107 108-107HuMab-129_HeavyChain_VDJ-Region 401 1-119 120-119HuMab-129_LightChain_VJ-Region 402 1-106 107-106HuMab-132_HeavyChain_VDJ-Region 403 1-125 126-125HuMab-132_LightChain_VJ-Region 404 1-108 109-108HuMab-143_HeavyChain_VDJ-Region 405 1-120 121-120HuMab-143_LightChain_VJ-Region 406 1-107 108-107HuMab-150_HeavyChain_VDJ-Region 407 1-122 123-122HuMab-150_LightChain_VJ-Region 408 1-107 108-107HuMab-152_HeavyChain_VDJ-Region 409 1-121 122-121HuMab-152_LightChain_VJ-Region 410 1-107 108-107HuMab-153_HeavyChain_VDJ-Region 411 1-121 122-121HuMab-153_LightChain_VJ-Region 412 1-107 108-107HuMab-159_HeavyChain_VDJ-Region 413 1-126 127-126HuMab-159_LightChain_VJ-Region 414 1-107 108-107HuMab-160_HeavyChain_VDJ-Region 415 1-121 122-121HuMab-160_LightChain_VJ-Region 416 1-107 108-107HuMab-162_HeavyChain_VDJ-Region 417 1-124 125-124HuMab-162_LightChain_VJ-Region 418 1-107 108-107HuMab-163_HeavyChain_VDJ-Region 419 1-122 123-122HuMab-163_LightChain_VJ-Region 420 1-107 108-107HuMab-166_HeavyChain_VDJ-Region 421 1-121 122-121HuMab-166_LightChain_VJ-Region 422 1-107 108-107HuMab-167_HeavyChain_VDJ-Region 423 1-121 122-121HuMab-169_HeavyChain_VDJ-Region 424 1-121 122-121HuMab-169_LightChain_VJ-Region 425 1-107 108-107HuMab-708_HeavyChain_VH-Region 426 1-122 123-122HuMab-708_HeavyChain_V-Region 427 1-122 123-122HuMab-708_LightChain_VL-Region 428 1-107 108-107HuMab-708_LightChain_V-Region 429 1-107 108-107huMAb-anti-MSP10.1_LightChain_VJ-Region 430 1-108 109-108huMAb-anti-MSP10.2_LightChain_VJ-Region 431 1-108 109-108HUMAB-Clone_18_VJ-Region 432 1-108 109-108 HUMAB-Clone_22_VJ-Region 4331-108 109-108 HuMab-LG12_μChain_VDJ-Region_Precursor 434 1-139 140-144HuMab_LC5002-002_LightChain_V-Region 435 1-107 108-107HuMab_LC5002-002_gamma1-Chain_V-Region 436 1-119 120-119HuMab_LC5002-003_LightChain_V-Region 437 1-107 108-107HuMab_LC5002-003_gamma1-Chain_V-Region 438 1-119 120-119HuMab_LC5002-005_LightChain_V-Region 439 1-107 108-107HuMab_LC5002-005_gamma1-Chain_V-Region 440 1-118 119-118HuMab_LC5002-007_LightChain_V-Region 441 1-107 108-107HuMab_LC5002-007_gamma1-Chain_V-Region 442 1-123 124-123HuMab_LC5002-018_gamma1-Chain_V-Region 443 1-119 120-119Ibalizumab_HeavyChain1 444 1-122 123-449 Ibalizumab_LightChain1 4451-112 113-219 Ibritumomab_tiuxetan_HeavyChain 446 1-122 123-443Ibritumomab_tiuxetan_LightChain 447 1-106 107-209 Icrunumab_HeavyChain1448 1-126 127-456 Icrunumab_LightChain1 449 1-108 109-215Idarucizumab_HeavyChain1 450 1-122 123-225 Idarucizumab_LightChain1 4511-112 113-219 Igatuzuab_HeavyChain1 452 1-120 121-444Igatuzuab_LightChain1 453 1-105 106-212 IGF-IR_HUMAB-1A_HeavyChain 4541-119 120-119 IGF-IR_HUMAB-23_HeavyChain 455 1-119 120-119IGF-IR_HUMAB-23_LightChain 456 1-107 108-107 IGF-IR_HUMAB-8_HeavyChain457 1-119 120-119 IGF-IR_HUMAB-8_LightChain 458 1-107 108-107ImAb1_LightChain 459 1-129 130-236 ImAb1_gamma1-Chain 460 1-133 134-227Imalumab_HeavyChain1 461 1-118 119-448 Imalumab_LightChain1 462 1-107108-214 Imgatuzumab_HeavyChain1 463 1-120 121-449Imgatuzumab_LightChain1 464 1-106 107-213 Inclacumab_HeavyChain1 4651-124 125-451 Inclacumab_LightChain1 466 1-107 108-214Indatuximab_ravtansine_HeavyChain1 467 1-122 123-449Indatuximab_ravtansine_LightChain1 468 1-107 108-214Indusatumab_vedotin_HeavyChain1 469 1-119 120-449Indusatumab_vedotin_LightChain1 470 1-107 108-214Inebilizumab_HeavyChain1 471 1-121 122-451 Inebilizumab_LightChain1 4721-111 112-218 Insulin_peglispro_Fragment1 473 1-30  31-30Insulin_peglispro_Fragment2 474 1-21  22-21 Interferon_beta-1b_chain1475 1-120 121-165 Intetumumab_HeavyChain1 476 1-119 120-449Intetumumab_LightChain1 477 1-108 109-215Iodine_(1241)_Girentuximab_HeavyChain1 478 1-119 120-449Iodine_(1241)_Girentuximab_LightChain1 479 1-107 108-214Iodine_(1311)_Derlotuxiab_biotin_HeavyChain1 480 1-117 118-445Iodine_(1311)_Derlotuxiab_biotin_LightChain1 481 1-106 107-213Iodine_(1311)_Derlotuximab_biotin_HeavyChain1 482 1-120 121-450Iodine_(1311)_Derlotuximab_biotin_LightChain1 483 1-108 109-215Ipilimumab_HeavyChain 484 1-118 119-448 Ipilimumab_LightChain 485 1-108109-215 Iratumumab_HeavyChain1 486 1-107 108-107 Iratumumab_LightChain1487 1-62  63-62 Isatuximab_HeavyChain1 488 1-120 121-450Isatuximab_LightChain1 489 1-107 108-214 Itolizumab_HeavyChain1 4901-119 120-449 Itolizumab_LightChain1 491 1-107 108-214Ixekizumab_HeavyChain1 492 1-119 120-445 Ixekizumab_LightChain1 4931-112 113-219 Labetuzumab_govitecan_HeavyChain1 494 1-119 120-449Labetuzumab_govitecan_LightChain1 495 1-106 107-213Lambrolizumab_HeavyChain1 496 1-120 121-447 Lambrolizumab_LightChain1497 1-111 112-218 Lampalizumab_HeavyChain1 498 1-115 116-223Lampalizumab_LightChain1 499 1-107 108-214 Lanadelumab_HeavyChain1 5001-122 123-451 Lanadelumab_LightChain1 501 1-106 107-213Landogrozumab_HeavyChain1 502 1-113 114-439 Landogrozumab_LightChain1503 1-108 109-215 Laprituximab_emtansine_HeavyChain1 504 1-119 120-448Laprituximab_emtansine_LightChain1 505 1-107 108-214Lealesoab_HeavyChain1 506 1-119 120-438 Lealesoab_LightChain1 507 1-112113-218 Lebrikizumab_HeavyChain1 508 1-120 121-445Lebrikizumab_LightChain1 509 1-111 112-218 Lenercept_chain1 510 1-120121-409 Lenzilumab_HeavyChain1 511 1-119 120-449 Lenzilumab_LightChain1512 1-107 108-214 Lerdelimumab_HeavyChain1 513 1-115 116-442Lerdelimumab_LightChain1 514 1-109 110-215 Lexatumumab_HeavyChain1 5151-122 123-457 Lexatumumab_HeavyChain 516 1-121 122-451Lexatumumab_LightChain1 517 1-109 110-217 Lexatumumab_LightChain 5181-108 109-214 Libivirumab_HeavyChain1 519 1-112 113-219Libivirumab_LightChain1 520 1-129 130-459 Lifastuzumab_HeavyChain 5211-120 121-450 Lifastuzumab_LightChain 522 1-112 113-219Lifastuzumab_vedotin_HeavyChain1 523 1-119 120-449Lifastuzumab_vedotin_LightChain1 524 1-112 113-219Ligelizumab_HeavyChain1 525 1-123 124-453 Ligelizumab_LightChain1 5261-107 108-214 Lilotomab_HeavyChain1 527 1-119 120-443Lilotomab_LightChain1 528 1-107 108-214 Lintuzumab_HeavyChain1 529 1-111112-218 Lintuzumab_LightChain1 530 1-116 117-446 Lirilumab_HeavyChain1531 1-123 124-450 Lirilumab_LightChain1 532 1-107 108-214Lodelcizumab_HeavyChain1 533 1-118 119-448 Lodelcizumab_LightChain1 5341-106 107-213 Lokivetmab_HeavyChain1 535 1-118 119-452Lokivetmab_LightChain1 536 1-111 112-217Lorvotuzumab_mertansine_HeavyChain1 537 1-118 119-448Lorvotuzumab_mertansine_LightChain1 538 1-112 113-219 Lpathomab_VL 5391-112 113-112 Lpathomab_gamma1-Chain_VDJ-Region 540 1-122 123-122Lucatumumab_HeavyChain1 541 1-120 121-450 Lucatumumab_LightChain1 5421-112 113-219 Lulizumab_pegol_LightChain1 543 1-109 110-109Lulizumab_pegol_LightChain 544 1-108 109-108 Lumiliximab_HeavyChain1 5451-107 108-214 Lumiliximab_LightChain1 546 1-68   69-398Lumretuzumab_HeavyChain1 547 1-120 121-449 Lumretuzumab_LightChain1 5481-113 114-221 Lutetium_(177Lu)_lilotomab_satetraxetan_HeavyChain1 5491-119 120-443 Lutetium_(177Lu)_lilotomab_satetraxetan_LightChain1 5501-107 108-214 Margetuximab_HeavyChain1 551 1-120 121-450Margetuximab_LightChain1 552 1-107 108-214 Marzeptacog_alfa_HeavyChain1553 1-120 121-254 Marzeptacog_alfa_LightChain1 554 1-107 108-152Matuzumab_HeavyChain1_variant_3c08_H 555 1-121 122-223Matuzumab_HeavyChain1_variant_3c09_C 556 1-121 122-223Matuzumab_LightChain1_variant_3c08_L 557 1-106 107-212Matuzumab_LightChain1_variant_3c09_B 558 1-106 107-212Mavrilimumab_HeavyChain1 559 1-120 121-447 Mavrilimumab_LightChain1 5601-111 112-217 MDX-1303_HeavyChain1 561 1-108 109-215MDX-1303_LightChain1 562 1-123 124-453 Mepolizumab_HeavyChain1 563 1-113114-220 Mepolizumab_LightChain1 564 1-119 120-449Metelimumab_HeavyChain1 565 1-107 108-213 Metelimumab_LightChain1 5661-123 124-450 Milatuzumab_HeavyChain1 567 1-120 121-450Milatuzumab_LightChain1 568 1-112 113-219 Mirvetuximab_HeavyChain1 5691-118 119-447 Mirvetuximab_LightChain1 570 1-111 112-218Modotuximab_HeavyChain1 571 1-119 120-448 Modotuximab_LightChain1 5721-112 113-219 Mogamulizumab_HeavyChain1 573 1-119 120-449Mogamulizumab_LightChain1 574 1-112 113-219 Monalizumab_HeavyChain1 5751-125 129-452 Monalizumab_LightChain1 576 1-107 108-214Motavizumab_HeavyChain 577 1-120 121-450 Motavizumab_HeavyChain_variant578 1-120 121-450 Motavizumab_LightChain 579 1-106 107-213Motavizumab_LightChain_variant 580 1-106 107-213Moxetumomab_pasudotox_HeavyChain1 581 1-120 121-476Moxetumomab_pasudotox_LightChain1 582 1-108 109-108Muromonab-CD3_HeavyChain 583 1-119 120-450 Muromonab-CD3_LightChain 5841-106 107-213 Namilumab_HeavyChain1 585 1-119 120-449Namilumab_LightChain1 586 1-107 108-214Naptumomab_estafenatox_HeavyChain 587 1-120 121-458Naptumomab_estafenatox_LightChain 588 1-107 108-214Narnatumab_HeavyChain1 589 1-122 123-452 Narnatumab_LightChain1 5901-107 108-214 Natalizumab_HeavyChain1 591 1-106 107-213Natalizumab_LightChain1 592 1-123 124-450 Navicixizumab_HeavyChain1 5931-119 120-445 Navicixizumab_HeavyChain2 594 1-121 122-447Navicixizumab_LightChain1 595 1-111 112-218 Navivumab_HeavyChain1 5961-126 127-459 Navivumab_LightChain1 597 1-108 109-215Ndimab-varB_HeavyChain 598 1-126 127-724 Ndimab-varB_LightChain 5991-108 109-215 Necitumumab_HeavyChain1 600 1-121 122-451Necitumumab_LightChain1 601 1-107 108-214 Neliximab_HeavyChain_VH-Region602 1-124 125-132 Neliximab_HeavyChain_VH-Region_variant1 603 1-124125-124 Neliximab_LightChain_VL-Region 604 1-106 107-106Neliximab_LightChain_VL-Region_variant1 605 1-106 107-118Nemolizumab_HeavyChain1 606 1-121 122-445 Nemolizumab_LightChain1 6071-107 108-214 Nesvacumab_HeavyChain1 608 1-122 123-452Nesvacumab_LightChain1 609 1-107 108-214 Neuradiab_HeavyChain1 610 1-112113-219 Neuradiab_LightChain1 611 1-118 119-454 Nimotuzumab_HeavyChain1612 1-114 115-114 Nimotuzumab_LightChain1 613 1-123 124-123Nivolumab_HeavyChain1 614 1-113 114-440 Nivolumab_LightChain1 615 1-107108-214 Obiltoxaximab_HeavyChain1 616 1-119 120-449Obiltoxaximab_LightChain1 617 1-107 108-214 Obinutuzumab_HeavyChain1 6181-119 120-449 Obinutuzumab_LightChain1 619 1-112 113-219Ocaratuzumab_HeavyChain1 620 1-121 122-450 Ocaratuzumab_LightChain1 6211-106 107-213 Ocrelizumab_HeavyChain1 622 1-106 107-213Ocrelizumab_LightChain1 623 1-122 123-452 Ofatumumab_HeavyChain1 6241-107 108-214 Ofatumumab_LightChain1 625 1-122 123-452Olaratumab_HeavyChain1 626 1-127 128-457 Olaratumab_LightChain1 6271-107 108-214 Olizuab_HeavyChain1 628 1-120 121-447 Olizuab_LightChain1629 1-110 111-217 Olokizumab_HeavyChain1 630 1-120 121-447Olokizumab_LightChain1 631 1-107 108-214 Omalizumab_HeavyChain 632 1-121122-447 Omalizumab_LightChain 633 1-111 112-215 Onartuzumab_HeavyChain1634 1-119 120-449 Onartuzumab_HeavyChain2 635 1-120 121-227Onartuzumab_LightChain1 636 1-113 114-220 Ontuxizumab_HeavyChain1 6371-124 125-454 Ontuxizumab_LightChain1 638 1-108 109-215Opicinumab_HeavyChain1 639 1-118 119-447 Opicinumab_LightChain1 6401-108 109-215 Oportuzumab_monatox_HeavyChain1 641 1-118 119-648Oportuzumab_monatox_SingleChain_variable_fragment 642 1-118 119-647Oreptacog_alfa_HeavyChain1 643 1-120 121-254 Oreptacog_alfa_LightChain1644 1-107 108-152 Orticumab_HeavyChain1 645 1-121 122-451Orticumab_LightChain1 646 1-110 111-216 Otelixizumab_HeavyChain1 6471-119 120-449 Otelixizumab_LightChain1 648 1-110 111-216Otlertuzumab_HeavyChain1 649 1-116 117-483 Oxelumab_HeavyChain1 6501-120 121-449 Oxelumab_LightChain1 651 1-107 108-214Ozanezumab_HeavyChain1 652 1-113 114-443 Ozanezumab_LightChain1 6531-112 113-219 Ozoralizumab_HeavyChain1 654 1-115 116-363Palivizumab_HeavyChain 655 1-120 121-450 Palivizumab_LightChain 6561-106 107-213 Palivizumab_VH-Region 657 1-120 121-120Pamrevlumab_HeavyChain1 658 1-120 121-449 Pamrevlumab_LightChain1 6591-107 108-214 Panitumumab_HeavyChain1 660 1-107 108-214Panitumumab_LightChain1 661 1-119 120-435 Pankoab_HeavyChain1 662 1-114115-442 Pankoab_LightChain1 663 1-110 111-217 Pankoab_LightChain2 6641-110 111-217 PankoMab_HeavyChain_VDJ-Region 665 1-117 118-117PankoMab_LightChain_VJ-Region 666 1-112 113-113 Panobacumab_HeavyChain1667 1-116 117-570 Panobacumab_LightChain1 668 1-112 113-219Panobacumab_LightChain2 669 1-120 121-138 Parsatuzumab_HeavyChain1 6701-123 124-453 Parsatuzumab_LightChain1 671 1-112 113-219Pascolizumab_HeavyChain1 672 1-111 112-218 Pascolizumab_LightChain1 6731-121 122-451 Pasotuxizumab_HeavyChain1 674 1-121 122-504Pasotuxizumab_SingleChain 675 1-121 122-505 Pateclizumab_HeavyChain1 6761-118 119-447 Pateclizumab_LightChain1 677 1-107 108-214Patritumab_HeavyChain1 678 1-117 118-447 Patritumab_hinge-CH2—CH3 6791-120 121-227 Patritumab_LightChain1 680 1-113 114-220Pembrolizumab_HeavyChain1 681 1-120 121-447 Pembrolizumab_LightChain1682 1-111 112-218 Perakizumab_HeavyChain1 683 1-122 123-452Perakizumab_LightChain1 684 1-108 109-215 Pertuzuab_HeavyChain1 6851-117 118-444 Pertuzuab_LightChain1 686 1-106 107-213Pertuzumab_HeavyChain 687 1-107 108-214 Pertuzumab_LightChain 688 1-119120-448 Pexelizumab_h5g1.1-scFv 689 1-111 112-250Pexelizumab_h5g1.1VHC_+_F_Heavy_Chain_V-Region 690 1-115 116-115Pexelizumab_h5g1.1VHC_+_F_Light_Chain_V-Region 691 1-106 107-106PF-05082566_HeavyChain1 692 1-116 117-442 PF-05082568_LightChain1 6931-108 109-214 Pidilizumab_HeavyChain1 694 1-117 118-447Pidilizumab_LightChain1 695 1-106 107-213Pinatuzumab_vedotin_HeavyChain1 696 1-120 121-450Pinatuzumab_vedotin_LightChain1 697 1-112 113-219 Placulumab_chain1 6981-107 108-341 Placulumab_HeavyChain1 699 1-107 108-341Plozalizumab_HeavyChain1 700 1-117 118-447 Plozalizumab_LightChain1 7011-112 113-219 Pogalizumab_HeavyChain1 702 1-117 118-447Pogalizumab_LightChain1 703 1-107 108-214Polatuzumab_vedotin_HeavyChain1 704 1-117 118-447Polatuzumab_vedotin_LightChain1 705 1-111 112-218 Ponezumab_HeavyChain1706 1-116 117-442 Ponezumab_LightChain1 707 1-112 113-219Pritoxaximab_HeavyChain1 708 1-122 123-454 Pritoxaximab_LightChain1 7091-107 108-214 Pritumumab_HeavyChain1 710 1-107 108-214Pritumumab_LightChain1 711 1-120 121-450 Quilizumab_HeavyChain1 7121-117 118-447 Quilizumab_LightChain1 713 1-112 113-219Racotumomab_HeavyChain1 714 1-121 122-445 Racotumomab_LightChain1 7151-107 108-214 Racotumomab_scVH-VH′-VH_chain 716 1-115 116-363Radretumab_HeavyChain1 717 1-116 117-357 Radretumab_j_chain 718 1-120121-138 Rafivirumab_HeavyChain1 719 1-127 128-456 Rafivirumab_HeavyChain720 1-127 128-456 Rafivirumab_LightChain1 721 1-112 113-218Rafivirumab_LightChain 722 1-112 113-218 Ralpancizumab_HeavyChain1 7231-118 119-444 Ralpancizumab_LightChain1 724 1-107 108-214Ramucirumab_HeavyChain1 725 1-116 117-446 Ramucirumab_LightChain1 7261-107 108-214 Ranibiziuab_HeavyChain1 727 1-121 122-229Ranibiziuab_LightChain1 728 1-107 108-214 Ranibizumab_fab_fragment 7291-107 108-213 Ranibizumab_HeavyChain 730 1-123 124-231Ranibizumab_LightChain 731 1-123 124-218 Ranibizumab_LightChain_variant732 1-107 108-214 Refanezumab_HeavyChain1 733 1-126 127-456Refanezumab_LightChain1 734 1-112 113-219 REGN2810_HeavyChain1 735 1-115116-438 REGN2810_LightChain1 736 1-106 107-213rhuMab_HER2(9CI)_LightChain 737 1-110 111-217 rhuMab_HER2_HeavyChain 7381-74   75-405 rhuMab_HER2_LightChain 739 1-107 108-214rhuMab_HER2_LightChain_variant1 740 1-106 107-106rhuMab_HER2_LightChain_variant2 741 1-107 108-214rhuMab_HER2_LightChain_variant3 742 1-107 108-214rhuMab_HER2_LightChain_variant4 743 1-108 109-215rhuMab_HER2_LightChain_V-Region 744 1-107 108-107rhuMab_HER2_gamma1-Chain 745 1-120 121-450 rhuMab_HER2_gamma1-Chain 7461-120 121-450 rhuMab_HER2_gamma1-Chain_rhuMab_HER2_LightChain_sc405 7471-120 121-243 rhuMab_HER2_gamma1-Chain_variant1 748 1-120 121-450rhuMab_HER2_gamma1-Chain_variant2 749 1-120 121-450rhuMab_HER2_gamma1-Chain_variant3 750 1-120 121-450rhuMab_HER2_gamma1-Chain_V-Region 751 1-120 121-120rhuMAb-VEGF_HeavyChain1 752 1-123 124-453 rhuMAb-VEGF_LightChain1 7531-107 108-214 rhuMAb-VEGF_LightChain 754 1-107 108-214rhuMAb-VEGF_LightChain_VG-Region 755 1-107 108-107rhuMAb-VEGF_gamma1-Chain 756 1-123 124-453rhuMAb-VEGF_gamma1-Chain_VDG-Region 757 1-123 124-123Rilotumumab_HeavyChain1 758 1-120 121-446 Rilotumumab_LightChain1 7591-108 109-215 Rilotumumab_scFv-CH_chain 760 1-116 117-357Rinucumab_HeavyChain1 761 1-122 123-449 Rinucumab_HeavyChain 762 1-122123-448 Rinucumab_LightChain1 763 1-108 109-215 Risankizumab_HeavyChain1764 1-120 121-449 Risankizumab_LightChain1 765 1-107 108-214Rituximab_HeavyChain 766 1-121 122-451 Rituximab_HeavyChain_variant 7671-121 122-451 Rituximab_LightChain 768 1-106 107-213Rivabazumab_pegol_HeavyChain1 769 1-124 125-238Rivabazumab_pegol_LightChain1 770 1-107 108-214 Robatumumab_HeavyChain1771 1-118 119-448 Robatumumab_LightChain1 772 1-107 108-214Roledumab_HeavyChain1 773 1-126 127-456 Roledumab_LightChain1 774 1-107108-214 Romosozumab_fab_fragment 775 1-107 108-213Romosozumab_HeavyChain1 776 1-123 124-449 Romosozumab_LightChain1 7771-107 108-214 Rontalizuab_HeavyChain1 778 1-116 117-442Rontalizuab_LightChain1 779 1-109 110-216 Rontalizumab_HeavyChain1 7801-117 118-447 Rontalizumab_LightChain1 781 1-111 112-218Rovalpituzumab_tesirine_HeavyChain1 782 1-118 119-447Rovalpituzumab_tesirine_LightChain1 783 1-107 108-214Rovelizumab_HeavyChain1 784 1-111 112-218 Rovelizumab_LightChain1 7851-120 121-447 Ruplizumab_HeavyChain1 786 1-111 112-218Ruplizumab_LightChain1 787 1-118 119-447Sacituzumab_govitecan_HeavyChain1 788 1-121 122-451Sacituzumab_govitecan_LightChain1 789 1-107 108-214Samalizumab_HeavyChain1 790 1-117 118-442 Samalizumab_LightChain1 7911-107 108-214 Sarilumab_HeavyChain1 792 1-116 117-446Sarilumab_LightChain1 793 1-107 108-214 Satumomab_pendetide_HeavyChain794 1-114 115-432 Satumomab_pendetide_LightChain 795 1-107 108-210Secukinumab_HeavyChain1 796 1-127 128-457 Secukinumab_LightChain1 7971-108 109-215 Seribantumab_HeavyChain1 798 1-119 120-445Seribantumab_LightChain1 799 1-111 112-217 Setoxaximab_HeavyChain1 8001-121 122-451 Setoxaximab_LightChain1 801 1-113 114-220Sifalimumab_HeavyChain1 802 1-116 117-446 Sifalimumab_LightChain1 8031-108 109-215 Siltuximab_HeavyChain1 804 1-119 120-449Siltuximab_LightChain1 805 1-106 107-213 Simtuzumab_HeavyChain1 8061-116 117-443 Simtuzumab_LightChain1 807 1-112 113-219Sirukumab_HeavyChain1 808 1-119 120-449 Sirukumab_LightChain1 809 1-106107-213 Sofituzumab_vedotin_HeavyChain1 810 1-116 117-446Sofituzumab_vedotin_LightChain1 811 1-107 108-214Solanezumab_HeavyChain1 812 1-112 113-441 Solanezumab_HeavyChain 8131-112 113-442 Solanezumab_LightChain1 814 1-112 113-219Solitomab_HeavyChain1 815 1-113 114-502 Solitomab_SingleChain 816 1-113114-503 Sonepcizumab_LightChain_Precursor 817 1-127 128-234Sonepcizumab_gamma1-Chain_Precursor 818 1-140 141-455Stamulumab_HeavyChain1 819 1-105 106-211 Stamulumab_LightChain1 8201-117 118-446 Suptavumab_HeavyChain1 821 1-107 108-214Suptavumab_LightChain1 822 1-123 124-452 Suvizumab_HeavyChain1 823 1-118119-448 Suvizumab_LightChain1 824 1-113 114-220 Tabalumab_HeavyChain1825 1-123 124-450 Tabalumab_LightChain1 826 1-107 108-214Tacatuzuab_HeavyChain1 827 1-117 118-444 Tacatuzuab_LightChain1 8281-105 106-212 Tadocizumab_fab_fragment_HeavyChain 829 1-119 120-226Tadocizumab_fab_fragment_LightChain 830 1-107 108-194Talizumab_HeavyChain1 831 1-107 108-214 Talizumab_LightChain1 832 1-123124-453 Tamtuvetmab_HeavyChain1 833 1-107 108-213Tamtuvetmab_LightChain1 834 1-121 122-456 Tanezumab_HeavyChain 835 1-120121-120 Tanezumab_LightChain 836 1-107 108-109 Tarextumab_HeavyChain1837 1-115 116-441 Tarextumab_LightChain1 838 1-108 109-215Tefibazumab_HeavyChain1 839 1-112 113-112 Tefibazumab_LightChain1 8401-121 122-121 Tenatumomab_HeavyChain1 841 1-120 121-456Tenatumomab_LightChain1 842 1-112 113-219 Teneliximab_HeavyChain1 8431-107 108-214 Teneliximab_LightChain1 844 1-122 123-452Teplizumab_HeavyChain1 845 1-119 120-449 Teplizumab_LightChain1 8461-106 107-213 Teprotumumab_HeavyChain1 847 1-118 119-448Teprotumumab_LightChain1 848 1-108 109-215 Tesidolumab_HeavyChain1 8491-116 117-446 Tesidolumab_LightChain1 850 1-108 109-214Tezepelumab_HeavyChain1 851 1-122 123-448 Tezepelumab_LightChain1 8521-108 109-214 ThioMAb-chMA79b-HC(A118C)_HeavyChain 853 1-117 118-446ThioMab-hu10A8.v1-HC(A118C)_HeavyChain 854 1-119 120-449ThioMab-hu10A8.v1-HC(V205C)_HeavyChain 855 1-119 120-449ThioMab-hu10A8.v1-LC(A118C)_LightChain 856 1-107 108-214ThioMab-hu10A8.v1-LC(V205C)_LightChain 857 1-107 108-214ThioMAb-huMA79b.v17-HC(A118C)_HeavyChain 858 1-117 118-446ThioMAb-huMA79b.v17-HC(A118C)_LightChain 859 1-111 112-218ThioMAb-huMA79b.v18-HC(A118C)_HeavyChain 860 1-117 118-446ThioMAb-huMA79b.v28-HC(A118C)_LightChain 861 1-111 112-218ThioMAb-huMA79b.v28-LC(V205C)_LightChain 862 1-111 112-218Ticiliuab_HeavyChain1 863 1-122 123-444 Ticiliuab_LightChain1 864 1-106107-213 Tigatuzumab_HeavyChain1 865 1-119 120-449 Tigatuzumab_HeavyChain866 Tigatuzumab_LightChain1 867 1-106 107-213 Tigatuzumab_LightChain 8681-107 108-216 Tildrakizumab_HeavyChain1 869 1-116 117-446Tildrakizumab_LightChain1 870 1-107 108-214Tisotumab_vedotin_HeavyChain1 871 1-118 119-448Tisotumab_vedotin_LightChain1 872 1-107 108-214 Tocilizumab_HeavyChain1873 1-107 108-214 Tocilizumab_LightChain1 874 1-119 120-447Tosatoxumab_HeavyChain1 875 1-121 122-451 Tosatoxumab_LightChain1 8761-111 112-217 Tositumomab_HeavyChain 877 1-123 124-447Tositumomab_LightChain 878 1-106 107-210 Tovetumab_HeavyChain1 879 1-120121-446 Tovetumab_LightChain1 880 1-108 109-215 Tralokinumab_HeavyChain1881 1-122 123-449 Tralokinumab_LightChain1 882 1-108 109-214Trastuzuab_HeavyChain1 883 1-118 119-444 Trastuzuab_LightChain1 884Trastuzumab_emtansine_HeavyChain1 885 1-120 121-449Trastuzumab_emtansine_LightChain1 886 1-107 108-214Trastuzumab_HeavyChain1 887 Trastuzumab_HeavyChain 888 1-120 121-451Trastuzumab_HeavyChain_variant_In8z_B 889 1-120 121-220Trastuzumab_HeavyChain_variant_7637_H 890 1-15  Trastuzumab_LightChain1891 1-107 108-214 Trastuzumab_LightChain_variant_In8z_A 892 1-107108-214 Trastuzumab_LightChain_variant_7637_L 893 1-107 108-214TRC-105_HeavyChain1 894 1-118 119-448 TRC-105_LightChain1 895 1-106107-213 Tregalizumab_HeavyChain1 896 1-124 125-454Tregalizumab_LightChain1 897 1-111 112-218 Tremelimumab_HeavyChain1 8981-107 108-214 Tremelimumab_LightChain1 899 1-125 126-451Trevogrumab_HeavyChain1 900 1-120 121-447 Trevogrumab_LightChain1 9011-107 108-214 Tucotuzumab_celmoleukin_HeavyChain1 902 1-106 107-213Tucotuzumab_celmoleukin_LightChain1 903 1-116 117-579Ublituximab_HeavyChain1 904 1-118 119-448 Ublituximab_LightChain1 9051-106 107-213 Ulocuplumab_HeavyChain1 906 1-125 126-451Ulocuplumab_LightChain1 907 1-107 108-214 Urelumab_HeavyChain1 908 1-121122-448 Urelumab_LightChain1 909 1-107 108-216 Urtoxazumab_HeavyChain1910 1-107 108-214 Urtoxazumab_LightChain1 911 1-119 120-449Ustekinumab_HeavyChain1 912 1-107 108-214 Ustekinumab_LightChain1 9131-119 120-449 Vadastuximab_talirine_HeavyChain1 914 1-117 118-447Vadastuximab_talirine_LightChain1 915 1-107 108-214Vandortuzumab_vedotin_HeavyChain1 916 1-124 125-454Vandortuzumab_vedotin_LightChain1 917 1-113 114-221Vantictumab_HeavyChain1 918 1-118 119-443 Vantictumab_LightChain1 9191-107 108-213 Vanucizumab_HeavyChain1 920 1-129 130-463Vanucizumab_HeavyChain2 921 1-123 124-453 Vanucizumab_LightChain1 9221-110 111-213 Vanucizumab_LightChain2 923 1-107 108-214Varlilumab_HeavyChain1 924 1-119 120-452 Varlilumab_LightChain1 9251-107 108-214 Vatelizumab_HeavyChain1 926 1-119 120-446Vatelizumab_LightChain1 927 1-106 107-213 Vedolizumab_HeavyChain1 9281-121 122-451 Vedolizumab_LightChain1 929 1-112 113-219Veltuzumab_HeavyChain1 930 1-121 122-451 Veltuzumab_LightChain1 9311-106 107-213 Vesencumab_HeavyChain1 932 1-123 124-453Vesencumab_LightChain1 933 1-107 108-214 Visilizumab_HeavyChain1 9341-106 107-213 Visilizumab_LightChain1 935 1-120 121-446Volociximab_HeavyChain 936 1-124 125-451 Volociximab_LightChain 9371-108 109-215 Vorsetuzumab_HeavyChain1 939 1-118 119-448Vorsetuzumab_LightChain1 939 1-111 112-218Vorsetuzumab_mafodotin_HeavyChain1 940 1-118 119-448Vorsetuzumab_mafodotin_LightChain1 941 1-111 112-218Yttrium_(90Y)_clivatuzumab_tetraxetan_HeavyChain1 942 1-119 120-449Yttrium_(90Y)_clivatuzumab_tetraxetan_LightChain1 943 1-108 109-215Yttrium_Y_90_epratuzumab_tetraxetan_HeavyChain1 944 1-112 113-219Yttrium_Y_90_epratuzumab_tetraxetan_LightChain1 945 1-116 117-446Yttrium_Y_90_epratuzumab_HeavyChain1 946 1-115 116-442Yttrium_Y_90_epratuzumab_LightChain1 947 1-111 112-218Zalutumumab_HeavyChain1 948 1-107 108-214 Zalutumumab_LightChain1 9491-125 126-455 Zanolimumab_HO_HeavyChain 950 1-115 116-444Zanolimumab_LO_LightChain 951 1-108 109-214 Zatuximab_HeavyChain1 9521-119 120-448 Zatuximab_LightChain1 953 1-112 113-219

Accordingly, it is preferred that the at least one coding sequence ofthe RNA according to the present invention encodes a heavy chainvariable region and/or a light chain variable region of an antibody, oran antigen-binding fragment or variant of a heavy chain variable regionand/or a light chain variable region of an antibody. Preferably, theheavy chain variable region and/or the light chain variable regionencoded by the at least one coding sequence comprises or consists of anamino acid sequence as described in Table 4 above.

Table 5 below shows the amino acid positions of the heavy chain andlight chain CDRs in the heavy chain and light chain amino acid sequencesof exemplified antibodies, which are preferably encoded by the RNAaccording to the present invention as described herein. Thereby, a CDRof, for example, “22-41” means that amino acids 22-41 of the respectiveamino acid sequence (“Protein SEQ ID NO”) form the respective CDR. Thefirst column identifies whether the amino acid sequence (“Protein SEQ IDNO”) is of the heavy chain or of the light chain. Similarly to thevariable regions/constant regions shown in Table 4, the skilled personcan easily identify the heavy chain CDR's (CDRH1, CDRH2, CDRH3) and thelight chain CDR's (CDRL1, CDRL2, CDRL3) of the exemplified antibodiesbased on the information in Table 5. Moreover, on basis of thatinformation on amino acid sequence level, the skilled person can easilyidentify the corresponding RNA sequence fragments (i.e. the RNAsequences encoding the heavy chain/light chain CDR's, respectively), inparticular by using the RNA sequences shown in Table 3 corresponding tothe antibody of interest's amino acid sequence.

TABLE 5 CDRs of exemplified antibodies Name Protein SEQ ID NO CDR1 CDR2CDR3 AAB-003_gamma1-Chain 1 22-41 94-113 Abagovomab_HeavyChain 2 22-4151-60 94-113 Abagovomab_LightChain 3 22-41 29-38 86-105Abciximab_HeavyChain 4 22-41 94-113 Abciximab_LightChain 5 22-41 48-5786-105 Abituzumab_HeavyChain1 6 22-41 94-113 Abituzumab_LightChain1 722-41 48-57 86-105 Abrilumab_HeavyChain1 8 22-41 59-68 94-113Abrilumab_LightChain1 9 22-41 48-57 86-105Abrilumab_LightChain1_variant2 10 22-41 47-56 85-104Actoxumab_HeavyChain1 11 22-41 94-113 Actoxumab_LightChain1 12 22-4149-58 87-106 Adalimumab_HeavyChain 13 22-41 94-113 Adalimumab_LightChain14 22-41 48-57 86-105 Aducanumab_HeavyChain1 15 22-41 94-113Aducanumab_LightChain1 16 22-41 48-57 86-105 Afasevikumab_HeavyChain1 1722-41 94-113 Afasevikumab_LightChain1 18 22-41 48-57 86-105Aflibercept_Fusion_protein1 19 22-41 Afutuzuab_HeavyChain1 20 22-4192-111 Afutuzuab_LightChain1 21 22-41 52-61 89-108Afutuzumab_HeavyChain1 22 22-41 94-113 Afutuzumab_LightChain1 23 22-4153-62 91-110 Alacizumab_pegol_HeavyChain1 24 22-41 94-113Alacizumab_pegol_LightChain1 25 22-41 48-57 86-105Alemtuzumab_HeavyChain 26 22-41 96-115Alemtuzumab_HeavyChain_variant_Ibey_H 27 22-41 96-115Alemtuzumab_HeavyChain_variant_Icel_H 28 22-41 96-115Alemtuzumab_HeavyChain_variant_8005_H 29 22-41 96-115Alemtuzumab_LightChain 30 22-41 48-57 86-105Alemtuzumab_LightChain_variant_8005_L 31 22-41 48-57 86-105Alirocumab_HeavyChain1 32 22-41 94-113 Alirocumab_LightChain1 33 22-4154-63 92-111 ALX-0061_HeavyChain1 34 22-41 93-112 Amatuximab_HeavyChain135 22-41 Amatuximab_LightChain1 36 22-41 47-56 85-104Anetumab_ravtansine_HeavyChain1 37 22-41 94-113Anetumab_ravtansine_LightChain1 38 22-41 50-59 88-107Anifrolumab_HeavyChain1 39 22-41 51-60 94-113 Anifrolumab_LightChain1 4022-41 49-58 87-106 Anrukinzumab_HeavyChain1 41 22-41 93-112Anrukinzumab_LightChain1 42 22-41 52-61 90-109 Apolizumab_HeavyChain1 4322-41 93-112 Apolizumab_LightChain1 44 22-41 29-38 86-105Apomab_HeavyChain 45 22-41 93-112 Apomab_LightChain 46 22-41 46-5584-103 Aquaporumab_LightChain 47 22-41 87-106Arcitumomab_99tc_HeavyChain 48 22-41 376-385 96-115Arcitumomab_99tc_LightChain 49 22-41 47-56 85-104Ascrinvacumab_HeavyChain1 50 22-41 53-62 95-114Ascrinvacumab_LightChain1 51 22-41 49-58 87-106 Aselizub_HeavyChain1 5222-41 91-110 Aselizub_HeavyChain2 53 22-41 91-110 Aselizuab_LightChain154 22-41 50-59 88-107 Atezolizumab_HeavyChain1 55 22-41 94-113Atezolizumab_LightChain1 56 22-41 48-57 86-105 Atinumab_HeavyChain1 5722-41 94-113 Atinumab_LightChain1 58 22-41 48-57 86-105Atlizuab_HeavyChain1 59 22-41 92-111 Atlizuab_LightChain1 60 22-41 47-5685-104 Aurograb_SingleChain 61 22-41 192-201 230-249 Avelumab_HeavyChain1 62 22-41 51-60 94-113 Avelumab_LightChain1 63 22-4150-59 88-107 Bapineuzumab_HeavyChain1 64 22-41 94-113Bapineuzumab_LightChain1 65 22-41 53-62 91-110 Basiliximab_HeavyChain 6622-41 49-58 92-111 Basiliximab_LightChain 67 22-41 47-56 85-104Bavituximab_HeavyChain 68 22-41 94-113 Bavituximab_LightChain 69 22-4148-57 86-105 Bavituximab_LightChain_variant_8734_L 70 22-41 48-57 86-105Begelomab_HeavyChain1 71 22-41 415-424 Begelomab_LightChain1 72 22-4147-56 85-104 Benralizumab_HeavyChain1 73 22-41 Benralizumab_LightChain174 22-41 48-57 86-105 Betalutin_HeavyChain1 75 22-41 94-113Betalutin_LightChain1 76 22-41 86-105 Bevacituzuab_HeavyChain1 77 22-4192-111 Bevacituzuab_LightChain1 78 22-41 47-56 85-104Bevacizumab_154-aspartic_acid_LightChain 79 22-41 48-57 86-105Bevacizumab_154-substitution_deriv_LightChain 80 22-41 48-57 86-105Bevacizumab_180-serine_HeavyChain 81 22-41 94-113Bevacizumab_180-substitution_deriv_HeavyCahin 82 22-41 94-113Bevacizumab_beta_HeavyChain1 83 22-41 94-113Bevacizumab_beta_LightChain1 84 22-41 48-57 86-105 Bevacizumab_LcDomain85 22-41 Bevacizumab_HeavyChain 86 22-41 94-113Bevacizumab_HeavyChain_variant1 87 22-41 117-136 Bevacizumab_HeavyChain_V-Region 88 22-41 94-113 Bevacizumab_LightChain189 22-41 73-82 111-130  Bevacizumab_LightChain2 90 22-41 71-80 109-128 Bevacizumab_LightChain 91 22-41 48-57 86-105Bevacizumab_LightChain_VJ-Region 92 22-41 48-57 86-105Bevacizumab_LightChain_V-Region 93 22-41 48-57 86-105Bevacizumab-rhuMAb-VEGF_HeavyChain_gamma1-Chain_VDJ-Region 94 22-4194-113 Bevacizumab-rhuMAb-VEGF_LightChain_VJ-Region 95 22-41 48-5786-105 Bevacizumab_gamma1-Chain 96 22-41 94-113Bevacizumab_gamma1-Chain_CH3-Region_mutein 97 22-41 94-113Bezlotoxumab_HeavyChain1 98 22-41 94-113 Bezlotoxumab_LightChain1 9922-41 49-58 87-106 Bimagrumab_HeavyChain1 100 22-41 94-113Bimagrumab_HeavyChain 101 22-41 94-113 Bimagrumab_LightChain1 102 22-4150-59 88-107 Bimekizumab_HeavyChain1 103 22-41 107-116 94-113Bimekizumab_LightChain1 104 22-41 48-57 86-105 Bleselumab_HeavyChain1105 22-41 53-62 95-114 Bleselumab_LightChain1 106 22-41 49-57 86-105Blinatumomab_HeavyChain1 107 22-41 52-61 349-368 Blinatumomab_SingleChain 108 22-41 52-61 349-368 Blinatumumab_SingleChain_variable_fragment_fusion_protein_(bite) 10922-41 52-61 349-368  Blontuvetmab_HeavyChain 110 22-41 94-113Blontuvetmab_LightChain 111 22-41 54-63 Blosozumab_HeavyChain1 112 22-4194-113 Blosozumab_LightChain1 113 22-41 48-57 86-105Bococizumab_HeavyChain1 114 22-41 94-113 Bococizumab_LightChain1 11522-41 48-57 86-105 Brentuximab_vedotin_HeavyChain1 116 22-41 51-60Brentuximab_vedotin_LightChain1 117 22-41 52-61 90-109Briakinumab_HeavyChain1 118 22-41 94-113 Briakinumab_LightChain1 11922-41 49-58 87-106 Brodalumab_HeavyChain1 120 22-41 94-113Brodalumab_LightChain1 121 22-41 48-57 86-105 Brolucizumab_HeavyChain1122 22-41 49-58 87-106 Brolucizumab_scfv_fragment 123 22-41 49-58 87-106Brontictuzumab_HeavyChain1 124 22-41 94-113 Brontictuzumab_LightChain1125 22-41 88-107 BTT-1023_HeavyChain1 126 22-41 94-113BTT-1023_LightChain1 127 22-41 48-57 86-105 Burosumab_HeavyChain1 12822-41 94-113 Burosumab_LightChain1 129 22-41 48-57 86-105Canakinumab_HeavyChain1 130 22-41 94-113 Canakinumab_HeavyChain 13122-41 94-113 Canakinumab_LightChain1 132 22-41 86-105Canakinumab_LightChain 133 22-41 86-105Canakinumab_LightChain_variant_8836_L 134 22-41 94-113Cantuzumab_HeavyChain1 135 22-41 Cantuzumab_HeavyChain 136 22-41Cantuzumab_LightChain1 137 22-41 53-62 91-110Cantuzumab_mertansine_HeavyChain1 138 22-41Cantuzumab_mertansine_LightChain1 139 22-41 53-62 91-110Cantuzumab_ravtansine_HeavyChain1 140 22-41Cantuzumab_ravtansine_LightChain1 141 22-41 53-62 91-110 Caplacizumab142 22-41 94-113 Caplacizumab_HeavyChain1 143 22-41 94-113Caplacizumab_HeavyChain1 144 22-41 94-113 Carlumab_HeavyChain1 145 22-41102-111 94-113 Carlumab_LightChain1 146 22-41 49-58 87-106Cergutuzumab_amunaleukin_HeavyChain1 147 22-41 94-113Cergutuzumab_amunaleukin_HeavyChain2 148 22-41 94-113Cergutuzumab_amunaleukin_LightChain1 149 22-41 48-57 86-105Certolizumab_pegol_HeavyChain1 150 22-41 59-68 94-113Certolizumab_pegol_HeavyChain 151 22-41 59-68 94-113Certolizumab_pegol_LightChain1 152 22-41 48-57 86-105Certolizumab_pegol_LightChain 153 22-41 48-57 86-105Cetuximab_HeavyChain 154 22-41  92-101 93-112Cetuximab_HeavyChain_variant 155 22-41  92-101 93-112Cetuximab_LightChain 156 22-41 86-105 Cetuximab_LightChain_variant 15722-41 86-105 Citatuzumab_bogatox_HeavyChain1 158 22-41 100-119 Citatuzumab_bogatox_LightChain1 159 22-41 53-62 91-110Cixutumumab_HeavyChain1 160 22-41 94-113 Cixutumumab_LightChain1 16122-41 47-56 85-104 Clazakizumab_HeavyChain1 162 22-41 51-60 93-112Clazakizumab_LightChain1 163 22-41 48-57 86-105Clivatuzumab_tetraxetan_HeavyChain1 164 22-41 94-113Clivatuzumab_tetraxetan_LightChain1 165 22-41 49-58Codrituzumab_HeavyChain1 166 22-41 94-113 Codrituzumab_LightChain1 16722-41 53-62 91-110 Coltuximab_ravtansine_HeavyChain1 168 22-41 94-113Coltuximab_ravtansine_LightChain1 169 22-41 47-56 85-104Conatumumab_CV_HeavyChain 170 22-41 95-114 Conatumumab_CV_LightChain 17122-41 49-58 87-106 Conatumumab_HeavyChain1 172 22-41 95-114Conatumumab_HeavyChain 173 22-41 95-114 Conatumumab_LightChain1 17422-41 49-58 87-106 Conatumumab_LightChain 175 22-41 49-58 87-106Concizumab_HeavyChain1 176 22-41 94-113 Concizumab_LightChain1 177 22-4153-62 91-110 Crenezumab_HeavyChain1 178 22-41 94-113Crenezumab_LightChain1 179 22-41 53-62 91-110 Crotedumab_HeavyChain1 18022-41 94-113 Crotedumab_HeavyChain2 181 22-41 94-113Crotedumab_LightChain1 182 22-41 48-57 86-105 Crotedumab_LightChain2 18322-41 48-57 86-105 Dacetuzumab_HeavyChain1 184 22-41 101-110 94-113Dacetuzumab_LightChain1 185 22-41 53-62 Dacliximab_LightChain_VJ-Region186 22-41 47-56 85-104 Dacliximab_gamma2-Chain_VDJ-Region 187 22-4194-113 Daclizumab_HeavyChain 188 22-41 94-113 Daclizumab_LightChain 18922-41 47-56 85-104 Dalotuzumab_HeavyChain1 190 22-41Dalotuzumab_LightChain1 191 22-41 Dapirolizumab_pegol_HeavyChain1 19222-41 93-112 Dapirolizumab_pegol_LightChain1 193 22-41 48-57 86-105Daratumumab_HeavyChain1 194 22-41 Daratumumab_LightChain1 195 22-4148-57 86-105 Dectrekumab_HeavyChain1 196 22-41 94-113Dectrekumab_LightChain1 197 22-41 48-57 86-105 Demcizumab_HeavyChain1198 22-41 94-113 Demcizumab_LightChain1 199 22-41 52-61 90-109Denintuzumab_mafodotin_HeavyChain1 200 22-41 95-114Denintuzumab_mafodotin_LightChain1 201 22-41 47-56 85-104Denosumab_HeavyChain 202 22-41 94-113 Denosumab_LightChain 203 22-4149-58 Depatuxizumab_HeavyChain1 204 22-41 94-113Depatuxizumab_LightChain1 205 22-41 48-57 86-105Depatuxizumab_mafodotin_HeavyChain1 206 22-41 94-113Depatuxizumab_mafodotin_LightChain1 207 22-41 48-57 86-105Dinutuximab_beta_HeavyChain1 208 22-41 94-113Dinutuximab_beta_LightChain1 209 22-41 Dinutuximab_HeavyChain1 210 22-4194-113 Dinutuximab_LightChain1 211 22-41 Dinutuximab_LightChain 21222-41 Diridavumab_HeavyChain1 213 22-41 94-113 Diridavumab_LightChain1214 22-41 49-58 87-106 Domagrozumab_HeavyChain1 215 22-41 94-113Domagrozumab_HeavyChain 216 22-41 94-113 Domagrozumab_LightChain1 21722-41 48-57 86-105 Drozituab_HeavyChain1 218 22-41 92-111Drozituab_LightChain1 219 22-41 46-55 84-103 Drozitumab_HeavyChain1 22022-41 94-113 Drozitumab_LightChain1 221 22-41 46-55 84-103Duligotumab_HeavyChain1 222 22-41 94-113 Duligotumab_LightChain1 22322-41 48-57 86-105 Duligotuzumab_HeavyChain1 224 22-41 94-113Duligotuzumab_LightChain1 225 22-41 48-57 86-105 Dupilumab_HeavyChain1226 22-41 94-113 Dupilumab_LightChain1 227 22-41 53-62 91-110Durvalumab_HeavyChain1 228 22-41 94-113 Durvalumab_LightChain1 229 22-4149-58 87-106 Dusigitumab_HeavyChain1 230 22-41 94-113Dusigitumab_LightChain1 231 22-41 49-58 87-106 Ecromeximab_HeavyChain1232 22-41 Ecromeximab_LightChain1 233 22-41 Eculizumab_HeavyChain1 23422-41 93-112 Eculizumab_LightChain1 235 22-41 29-38 86-105Efalizumab_HeavyChain 236 22-41 103-112 96-115 Efalizumab_LightChain 23722-41 48-57 86-105 Efungumab_SingleChain_variable_fragment 238 22-41185-194 96-115 Eldelumab_HeavyChain1 239 22-41  93-102 94-113Eldelumab_LightChain1 240 22-41 49-58 87-106 Elgemtumab_HeavyChain1 24122-41 94-113 Elgemtumab_LightChain1 242 22-41 48-57 86-105Elotuzumab_HeavyChain1 243 22-41 94-113 Elotuzumab_LightChain1 244 22-4148-57 86-105 Emactuzumab_HeavyChain1 245 22-41 93-112Emactuzumab_LightChain1 246 22-41 48-57 86-105 Emibetuzumab_HeavyChain1247 22-41 94-113 Emibetuzumab_LightChain1 248 22-41 32-41 87-106Emicizumab_HeavyChain1 249 22-41 94-113 Emicizumab_HeavyChain2 250 22-4159-68 Emicizumab_LightChain1 251 22-41 48-57 86-105Enavatuzumab_HeavyChain1 252 22-41 96-115 Enavatuzumab_LightChain1 25322-41 90-109 Enfortumab_HeavyChain 254 22-41 58-67 94-113Enfortumab_LightChain 255 22-41 48-57 86-105Enfortumab_vedotin_HeavyChain1 256 22-41 58-67 94-113Enfortumab_vedotin_LightChain1 257 22-41 48-57 86-105Enoblituzumab_HeavyChain 258 22-41 58-67 94-113 Enoblituzumab_LightChain259 22-41 48-57 86-105 Enokizumab_HeavyChain1 260 22-41 94-113Enokizumab_LightChain1 261 22-41 48-57 86-105 Enokizumab_LightChain 26222-41 48-57 86-105 Enoticumab_HeavyChain1 263 22-41 94-113Enoticumab_LightChain1 264 22-41 48-57 86-105 Ensituximab_HeavyChain1265 22-41 93-112 Ensituximab_LightChain1 266 22-41 47-56 85-104Ensituximab_SingleChain_variable_fragment 267 22-41 185-194 96-115Entolimod_chain1 268 22-41 Epratuzumab_HeavyChain 269 22-41Epratuzumab_LightChain 270 22-41 54-63 92-111 Eptacog_beta_HeavyChain1271 22-41 Eptacog_beta_LightChain1 272 22-41 Erlizuab_HeavyChain1 27322-41 89-108 Erlizuab_LightChain1 274 22-41 47-56 85-104Etaracizumab_HeavyChain1 275 22-41 94-113 Etaracizumab_LightChain1 27622-41 86-105 Etrolizuab_HeavyChain1 277 22-41 92-111Etrolizuab_HeavyChain2 278 22-41 92-111 Etrolizuab_LightChain1 279 22-4185-104 Etrolizumab_HeavyChain1 280 22-41 93-112 Etrolizumab_LightChain1281 22-41 86-105 Evinacumab_HeavyChain1 282 22-41 Evinacumab_LightChain1283 22-41 48-57 86-105 Evolocumab_HeavyChain1 284 22-41 94-113Evolocumab_LightChain1 285 22-41 50-59 88-107 Exbivirumab_HeavyChain1286 22-41 Exbivirumab_LightChain1 287 22-41 85-104Farletuzumab_HeavyChain1 288 22-41 Farletuzumab_LightChain1 289 22-4149-58 87-106 Fasinumab_HeavyChain1 290 22-41 59-68 94-113Fasinumab_LightChain1 291 22-41 48-57 86-105 Fezakinumab_HeavyChain1 29222-41 94-113 Fezakinumab_LightChain1 293 22-41 50-59 88-107FG-3019_HeavyChain1 294 22-41 93-112 FG-3019_LightChain1 295 22-41 48-5786-105 Fibatuzumab_HeavyChain1 296 22-41 51-60 94-113Fibatuzumab_LightChain1 297 22-41 48-57 86-105 Ficlatuzumab_HeavyChain1298 22-41 94-113 Ficlatuzumab_HeavyChain 299 22-41 93-112Ficlatuzumab_LightChain1 300 22-41 48-57 Figitumumab_HeavyChain1 30122-41 94-113 Figitumumab_LightChain1 302 22-41 48-57 86-105Firivumab_HeavyChain1 303 22-41 94-113 Firivumab_LightChain1 304 22-4185-94 Flanvotumab_HeavyChain1 305 22-41  93-102 94-113Flanvotumab_LightChain1 306 22-41 48-57 86-105 Fletikumab_HeavyChain1307 22-41 94-113 Fletikumab_LightChain1 308 22-41 48-57 86-105Fontolizumab_HeavyChain1 309 22-41 94-113 Fontolizumab_LightChain1 31022-41 48-57 86-105 Foralumab_HeavyChain1 311 22-41 94-113Foralumab_LightChain1 312 22-41 48-57 86-105 Foravirumab_HeavyChain1 31322-41 94-113 Foravirumab_HeavyChain 314 22-41 94-113Foravirumab_LightChain1 315 22-41 48-57 86-105 Fresolimumab_HeavyChain1316 22-41 94-113 Fresolimumab_LightChain1 317 22-41 49-58 87-106Fulranumab_HeavyChain1 318 22-41 94-113 Fulranumab_LightChain1 319 22-4148-57 86-105 Futuximab_HeavyChain1 320 22-41 51-60 94-113Futuximab_LightChain1 321 22-41 48-57 Galcanezumab_HeavyChain1 322 22-4151-60 94-113 Galcanezumab_LightChain1 323 22-41 48-57 86-105Galiximab_HeavyChain1 324 22-41 95-114 Galiximab_LightChain1 325 22-4149-58 87-106 Ganitumab_HeavyChain1 326 22-41 52-61 94-113Ganitumab_LightChain1 327 22-41 53-62 91-110 Gantenerumab_HeavyChain1328 22-41 94-113 Gantenerumab_LightChain1 329 22-41 49-58 87-106Gemtuzumab_HeavyChain1 330 22-41 94-113 Gemtuzumab_HeavyChain2 331 22-41102-111 Gemtuzumab_LightChain2 332 22-41 86-105Gemtuzumab_ozogamicin_LightChain1 333 22-41 47-56 85-104Gevokizumab_HeavyChain1 334 22-41 Gevokizumab_LightChain1 335 22-4148-57 Girentuximab_HeavyChain1 336 22-41 Girentuximab_LightChain1 33722-41 48-57 Glembatumumab_HeavyChain1 338 22-41 53-62 95-114Glembatumumab_LightChain1 339 22-41 48-57 86-105 Goilixiab_HeavyChain1340 22-41 94-113 Goilixiab_LightChain1 341 22-41 47-56 85-104Guselkumab_HeavyChain1 342 22-41 94-113 Guselkumab_LightChain1 343 22-4150-59 88-107 HuMab-001_HeavyChain_VDJ-Region 344 22-41 93-112HuMab-001_LightChain_VJ-Region 345 22-41 86-105HuMab-005_HeavyChain_gamma-Chain_VDJ-Region 346 22-41 51-60 94-113HuMab-005_LightChain_VJ-Region 347 22-41 49-58 87-106HuMab-006_HeavyChain_VDJ-Region 348 22-41 94-113HuMab-006_LightChain_VJ-Region 349 22-41 48-57 86-105HuMab-019_HeavyChain_VDJ-Region 350 22-41 93-112HuMab-021_HeavyChain_VDJ-Region 351 22-41 93-112HuMab-021_LightChain_VJ-Region 352 22-41 48-57 86-105HuMab-025_HeavyChain_VDJ-Region 353 22-41 93-112HuMab-025_LightChain_VJ-Region 354 22-41 48-57 86-105HuMab-027_HeavyChain_VDJ-Region 355 22-41 93-112HuMab-032_HeavyChain_VDJ-Region 356 22-41 104-113 93-112HuMab-032_LightChain_VJ-Region 357 22-41 48-57 86-105HuMab-033_HeavyChain_VDJ-Region 358 22-41 94-113HuMab-035_HeavyChain_VDJ-Region 359 22-41 24-33 93-112HuMab-036_HeavyChain_VDJ-Region 360 22-41 93-112HuMab-036_LightChain_VJ-Region 361 22-41 48-57 86-105HuMab-041_HeavyChain_VDJ-Region 362 22-41 51-60 94-113HuMab-044_HeavyChain_VDJ-Region 363 22-41 94-113HuMab-049_HeavyChain_VDJ-Region 364 22-41 94-113HuMab-049_LightChain_VJ-Region 365 22-41 48-57 86-105HuMab-050_HeavyChain_VDJ-Region 366 22-41 94-113HuMab-050_LightChain_VJ-Region 367 22-41 48-57 86-105HuMab-054_HeavyChain_VDJ-Region 368 22-41 93-112HuMab-054_LightChain_VJ-Region 369 22-41 48-57 86-105HuMab-055_HeavyChain_VDJ-Region 370 22-41 94-113HuMab-059_HeavyChain_VDJ-Region 371 22-41 94-113HuMab-059_LightChain_VJ-Region 372 22-41 49-58 87-106HuMab-060_HeavyChain_VDJ-Region 373 22-41 51-60 94-113HuMab-060_LightChain_VJ-Region 374 22-41 49-58 87-106HuMab-067_HeavyChain_VDJ-Region 375 22-41 51-60 94-113HuMab-072_HeavyChain_VDJ-Region 376 22-41 51-60 94-113HuMab-072_LightChain_VJ-Region 377 22-41 49-58 87-106HuMab-084_HeavyChain_VDJ-Region 378 22-41 94-113HuMab-084_LightChain_VJ-Region 379 22-41 48-57 86-105HuMab-091_HeavyChain_VDJ-Region 380 22-41 51-60 93-112HuMab-091_LightChain_VJ-Region 381 22-41 48-57 86-105HuMab-093_HeavyChain_VDJ-Region 382 22-41 51-60 94-113HuMab-098_HeavyChain_VDJ-Region 383 22-41 94-113HuMab-098_LightChain_VJ-Region 384 22-41 48-57 86-105HuMab-100_HeavyChain_VDJ-Region 385 22-41 94-113HuMab-106_HeavyChain_VDJ-Region 386 22-41 51-60 94-113HuMab-106_LightChain_VJ-Region 387 22-41 49-58 87-106HuMab_10F8_HeavyChain_V-Region 388 22-41 94-113HuMab_10F8_HeavyChain_V-Region_Precursor 389 22-41 113-132 HuMab_10F8_LightChain_V-Region 390 22-41 49-58 87-106HuMab_10F8_LightChain_V-Region_Precursor 391 22-41 69-78 107-126 HuMab-111_HeavyChain_VDJ-Region 392 22-41 94-113HuMab-111_LightChain_VJ-Region 393 22-41 49-58 87-106HuMab-123_HeavyChain_VDJ-Region 394 22-41 59-68 94-113HuMab-123_LightChain_VJ-Region 395 22-41 48-57 86-105HuMab-124_HeavyChain_VDJ-Region 396 22-41 59-68 94-113HuMab-125_HeavyChain_VDJ-Region 397 22-41 94-113HuMab-125_LightChain_VJ-Region 398 22-41 48-57 86-105HuMab-127_HeavyChain_VDJ-Region 399 22-41 31-40 94-113HuMab-127_LightChain_VJ-Region 400 22-41 48-57 86-105HuMab-129_HeavyChain_VDJ-Region 401 22-41 94-113HuMab-129_LightChain_VJ-Region 402 22-41 48-57 86-105HuMab-132_HeavyChain_VDJ-Region 403 22-41 94-113HuMab-132_LightChain_VJ-Region 404 22-41 48-57 86-105HuMab-143_HeavyChain_VDJ-Region 405 22-41 93-112HuMab-143_LightChain_VJ-Region 406 22-41 48-57 86-105HuMab-150_HeavyChain_VDJ-Region 407 22-41 51-60 94-113HuMab-150_LightChain_VJ-Region 408 22-41 49-58 87-106HuMab-152_HeavyChain_VDJ-Region 409 22-41 94-113HuMab-152_LightChain_VJ-Region 410 22-41 48-57 86-105HuMab-153_HeavyChain_VDJ-Region 411 22-41 94-113HuMab-153_LightChain_VJ-Region 412 22-41 48-57 86-105HuMab-159_HeavyChain_VDJ-Region 413 22-41 51-60 94-113HuMab-159_LightChain_VJ-Region 414 22-41 48-57 86-105HuMab-160_HeavyChain_VDJ-Region 415 22-41 HuMab-160_LightChain_VJ-Region416 22-41 48-57 86-105 HuMab-162_HeavyChain_VDJ-Region 417 22-41 94-113HuMab-162_LightChain_VJ-Region 418 22-41 48-57 86-105HuMab-163_HeavyChain_VDJ-Region 419 22-41 51-60 94-113HuMab-163_LightChain_VJ-Region 420 22-41 49-58 87-106HuMab-166_HeavyChain_VDJ-Region 421 22-41 94-113HuMab-166_LightChain_VJ-Region 422 22-41 48-57 86-105HuMab-167_HeavyChain_VDJ-Region 423 22-41 94-113HuMab-169_HeavyChain_VDJ-Region 424 22-41 59-68 94-113HuMab-169_LightChain_VJ-Region 425 22-41 48-57 86-105HuMab-708_HeavyChain_VH-Region 426 22-41 94-113HuMab-708_HeavyChain_V-Region 427 22-41 94-113HuMab-708_LightChain_VL-Region 428 22-41 48-57 86-105HuMab-708_LightChain_V-Region 429 22-41 48-57 86-105huMab-anti-MSP10.1_LightChain_VJ-Region 430 22-41 49-58 87-106huMab-anti-MSP10.2_LightChain_VJ-Region 431 22-41 49-58 87-106HUMAB-Clone_18_VJ-Region 432 22-41 48-57 86-105 HUMAB-Clone_22_VJ-Region433 22-41 48-57 86-105 HuMab-L612_μChain_VDJ-Region_Precursor 434 22-41113-132  HuMab_LC5002-002_LightChain_V-Region 435 22-41 48-57 86-105HuMab_LC5002-002_gamma1-Chain_V-Region 436 22-41 31-40 94-113HuMab_LC5002-003_LightChain_V-Region 437 22-41 48-57 86-105HuMab_LC5002-003_gamma1-Chain_V-Region 438 22-41 31-40 94-113HuMab_LC5002-005_LightChain_V-Region 439 22-41 48-57 86-105HuMab_LC5002-005_gamma1-Chain_V-Region 440 22-41 103-112 94-113HuMab_LC5002-007_LightChain_V-Region 441 22-41 49-58 87-106HuMab_LC5002-007_gamma1-Chain_V-Region 442 22-41 94-113HuMab_LC5002-018_gamma1-Chain_V-Region 443 22-41 31-40 94-113Ibalizumab_HeavyChain1 444 22-41 94-113 Ibalizumab_LightChain1 445 22-4154-63 92-111 Ibritumomab_tiuxetan_HeavyChain 446 22-41 51-60Ibritumomab_tiuxetan_LightChain 447 22-41 47-56 85-104Icrucumab_HeavyChain1 448 22-41 94-113 Icrucumab_LightChain1 449 22-4149-58 87-106 Idarucizumab_HeavyChain1 450 22-41 93-112Idarucizumab_LightChain1 451 22-41 53-62 91-110 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1237 22-41anti-HIV_PGT136_LightChain 1238 22-41 anti-HIV_PGT136_HeavyChain 123922-41 101-120  anti-HIV_PGT137_LightChain 1240 22-41 86-105anti-HIV_PGT137_HeavyChain 1241 22-41 100-119 anti-HIV_PGT141_LightChain 1242 22-41 90-99 91-110anti-HIV_PGT141_HeavyChain 1243 22-41  93-102 94-113anti-HIV_PGT142_LightChain 1244 22-41 90-99 91-110anti-HIV_PGT142_HeavyChain 1245 22-41  93-102 94-113anti-HIV_PGT143_LightChain 1245 22-41 90-99 91-110anti-HIV_PGT143_HeavyChain 1247 22-41  93-102 94-113anti-HIV_PGT144_LightChain 1248 22-41 90-99 91-110anti-HIV_PGT144_HeavyChain 1249 22-41  93-102 94-113anti-HIV_PGT145_LightChain 1250 22-41 91-110 anti-HIV_PGT145_HeavyChain1251 22-41  93-102 94-113 anti-HIV_PGT151_LightChain 1252 22-41 91-110anti-HIV_PGT151_HeavyChain 1253 22-41 anti-HIV_PGT152_LightChain 125422-41 91-110 anti-HIV_PGT152_HeavyChain 1255 22-41anti-HIV_VRC-CH30_LightChain 1255 22-41 anti-HIV_VRC-CH30_HeavyChain1257 22-41 103-122  anti-HIV_VRC-CH31_LightChain 1258 22-41anti-HIV_VRC-CH31_HeavyChain 1259 22-41 103-122 anti-HIV_VRC-CH32_LightChain 1260 22-41 anti-HIV_VRC-CH32_HeavyChain1261 22-41 103-122  anti-HIV_VRC-CH33_LightChain 1262 22-41anti-HIV_VRC-CH33_HeavyChain 1263 22-41 103-122 anti-HIV_VRC-CH34_LightChain 1264 22-41 anti-HIV_VRC-CH34_HeavyChain1265 22-41 103-122  anti-HIV_VRC-PG04_LightChain 1266 22-41 84-102anti-HIV_VRC-PG04_HeavyChain 1267 22-41 anti-HIV_VRC-PG04b_LightChain1268 22-41 84-101 anti-HIV_VRC-PG04b_HeavyChain 1269 22-41anti-HIV_VRC-PG20_LightChain 1270 22-41 anti-HIV_VRC-PG20_HeavyChain1271 22-41 anti-HIV_VRC-PG20_G-Chain 1272 22-41anti-HIV_VRC02_LightChain 1273 22-41 46-55 84-103anti-HIV_VRC02_HeavyChain 1274 22-41 94-113 anti-HIV_VRC03_LightChain1275 22-41 47-56 85-103 anti-HIV_VRC03_HeavyChain 1276 22-41anti-HIV_VRC23_LightChain 1277 22-41 48-57 86-105anti-HIV_VRC23_HeavyChain 1278 22-41  93-102 94-113anti-HIV_VRC23_G-Chain 1279 22-41 anti-HIV_5CCK_LightChain 1280 22-4150-59 88-107 anti-HIV_5CCK_HeavyChain 1281 22-41anti-HIV_5AWN_LightChain 1282 22-41 50-59 88-107anti-HIV_5AWN_HeavyChain 1283 22-41 anti-HIV_3QEG_LightChain 1284 22-4149-58 87-106 anti-HIV_3QEG_HeavyChain 1285 22-41 94-113anti-HIV_1NOX_K-Chain 1286 22-41 94-113 anti-HIV_1NOX_M-Chain 1287 22-4187-106 anti-HIV_3QEH_HeavyChain 1288 22-41 53-62 91-110anti-HIV_3QEH_G-Chain 1289 22-41  93-102 94-113 anti-HIV_2B1H_HeavyChain1290 22-41 94-113 anti-HIV_2B1H_LightChain 1291 22-41 49-58 87-106anti-HIV_3TNM_B-Chain 1292 22-41 88-107 anti-HIV_3TNM_A-Chain 1293 22-4195-114 anti-HIV_3UJJ_HeavyChain 1294 22-41 51-60 94-113anti-HIV_3UJJ_LightChain 1295 22-41 47-56 85-104anti-HIV_3UJ1_HeavyChain 1296 22-41 94-113 anti-HIV_3UJ1_LightChain 129722-41 47-56 85-104 anti-HIV_2QSC_HeavyChain 1298 22-41 94-113anti-HIV_2QSC_LightChain 1299 22-41 48-57 anti-HIV_3MLZ_HeavyChain 130022-41 51-60 93-112 anti-HIV_3MLZ_LightChain 1301 22-41 49-58 87-106anti-HIV_3MLX_I-Chain 1302 22-41 51-60 93-112 anti-HIV_3MLX_M-Chain 130322-41 48-57 86-105 anti-HIV_3MLW_I-Chain 1304 22-41 51-60 94-113anti-HIV_3MLW_M-Chain 1305 22-41 87-108 anti-HIV_3MLV_N-Chain 1306 22-4151-60 anti-HIV_3MLV_M-Chain 1307 22-41 85-104 anti-HIV_3MLU_LightChain1308 22-41 84-103 anti-HIV_3MLT_G-Chain 1309 22-41 85-104anti-HIV_3G01_HeavyChain 1310 22-41 93-112 anti-HIV_3G01_LightChain 131122-41 47-56 B5-104 anti-HIV_4XCY_J-Chain 1312 22-41 94-113anti-HIV_4XCY_K-Chain 1313 22-41 49-5B 87-108 anti-HIV_4YBL_C-Chain 131422-41 86-105 anti-HIV_4YBL_B-Chain 1315 22-41 95-114anti-HIV_4R4N_X-Chain 1316 22-41 48-57 86-105 anti-HIV_4R4B_F-Chain 131722-41 anti-HIV_3JUY_D-Chain 1318 22-41 94-113 anti-HIV_4KG5_HeavyChain1319 22-41 92-111 anti-HIV_4KG5_LightChain 1320 22-41 51-60 89-108anti-HIV-1_LightChain 1321 22-41 48-57 86-103 anti-HIV-1_LightChain 132222-41 49-58 87-104 anti-HIV-1_LightChain 1323 22-41anti-HIV-1_LightChain 1324 22-41 49-5B 87-104 anti-HIV-1_LightChain 132522-41 87-104 anti-HIV-1_LightChain 1326 22-41 49-58 87-104anti-HIV-1_HeavyChain 1327 22-41 74-83 94-113 anti-HIV-1_HeavyChain 132822-41 74-83 94-113 anti-HIV-1_HeavyChain 1329 22-41anti-HIV-1_HeavyChain 1330 22-41 96-115 anti-HIV-1_HeavyChain 1331 22-4194-113 anti-HIV-1_HeavyChain 1332 22-41 94-113 anti-HIV-1_HeavyChain1333 22-41 anti-HIV-1_HeavyChain 1334 22-41 94-113 anti-HIV-1_HeavyChain1335 22-41 93-112 anti-HIV-1_HeavyChain 1336 22-41 94-113anti-HIV-1_LightChain 1337 22-41 49-58 87-106 anti-HIV-1_LightChain 133822-41 49-58 87-106 anti-HIV-1_LightChain 1339 22-41 49-58 87-106anti-HIV-1_LightChain 1340 22-41 49-58 87-106 anti-HIV-1_LightChain 134122-41 53-62 91-110 anti-HIV-1_LightChain 1342 22-41 48-57 86-105anti-HIV-1_LightChain 1343 22-41 89-108 anti-HIV-1_LightChain 1344 22-4189-108 anti-HIV-1_HeavyChain 1345 22-41 99-118 anti-HIV-1_HeavyChain1346 22-41 99-118 anti-HIV-1_HeavyChain 1347 22-41 99-118anti-HIV-1_HeavyChain 1348 22-41 97-118 anti-HIV-1_HeavyChain 1349 22-4124-33 93-112 anti-HIV-1_HeavyChain 1350 22-41 97-116anti-HIV-1_HeavyChain 1351 22-41 anti-HIV-1_HeavyChain 1352 22-41 94-113anti-HIV_V3_HeavyChain 1353 22-41 51-60 94-113 anti-HIV_V3_HeavyChain1354 22-41 51-60 94-113 anti-HIV_V3_HeavyChain 1355 22-41 94-113anti-HIV_V3_HeavyChain 1356 22-41 93-112 anti-HIV_V3_HeavyChain 135722-41 51-60 94-113 anti-HIV_V3_HeavyChain 1358 22-41 51-60anti-HIV_V3_HeavyChain 1359 22-41 anti-HIV_V3_HeavyChain 1360 22-4194-113 anti-HIV_V3_HeavyChain 1361 22-41 94-113 anti-HIV_V3_HeavyChain1362 22-41 94-113 anti-HIV_V3_HeavyChain 1363 22-41 94-113anti-HIV_V3_HeavyChain 1364 22-41 anti-HIV_CD4bs_HeavyChain 1365 22-4158-67 94-113 anti-HIV_CD4bs_HeavyChain 1366 22-41 94-113anti-HIV_CD4bs_HeavyChain 1367 22-41 93-112 anti-HIV_CD4bs_HeavyChain1368 22-41 53-62 anti-HIV_CD4bs_HeavyChain 1369 22-41 96-115anti-HIV_CD4bs_HeavyChain 1370 22-41 94-113 anti-HIV_CD4bs_HeavyChain1371 22-41 94-113 anti-HIV_CD4bs_HeavyChain 1372 22-41anti-HIV_CD4bs_HeavyChain 1373 22-41 anti-HIV_CD4bs_HeavyChain 137422-41 94-113 anti-HIV_V2_HeavyChain 1375 22-41 94-113anti-HIV_V2_HeavyChain 1376 22-41 94-113 anti-HIV_V2_HeavyChain 137722-41 94-113 anti-HIV_V2_HeavyChain 1378 22-41 93-112anti-HIV_V2_HeavyChain 1379 22-41 94-113 anti-HIV_V2_HeavyChain 138022-41 94-113 anti-HIV_V3_LightChain 1381 22-41 47-56anti-HIV_V3_LightChain 1382 22-41 85-104 anti-HIV_V3_LightChain 138322-41 49-58 87-106 anti-HIV_V3_LightChain 1384 22-41  91-100 92-111anti-HIV_V3_LightChain 1385 22-41 47-56 85-104 anti-HIV_V3_LightChain1386 22-41 49-58 87-106 anti-HIV_V3_LightChain 1387 22-41 85-104anti-HIV_V3_LightChain 1388 22-41 47-56 85-104 anti-HIV_V3_LightChain1389 22-41 50-59 88-107 anti-HIV_V3_LightChain 1390 22-41 49-58 87-106anti-HIV_V3_LightChain 1391 22-41 86-105 anti-HIV_V3_LightChain 139222-41 85-94 86-105 anti-HIV_V3_LightChain 1393 22-41 85-104anti-HIV_V3_LightChain 1394 22-41 48-57 anti-HIV_V3_LightChain 139522-41 49-58 89-108 anti-HIV_V3_LightChain 1396 22-41 49-58 87-106anti-HIV_V3_LightChain 1397 22-41 85-104 anti-HIV_V3_LightChain 139822-41 49-58 87-106 anti-HIV_V3_LightChain 1399 22-41 53-62 91-110anti-HIV_V3_LightChain 1400 22-41 85-104 anti-HIV_V3_LightChain 140122-41 49-58 anti-HIV_V3_LightChain 1402 22-41 anti-HIV_V3_LightChain1403 22-41 47-56 85-104 anti-HIV_V3_LightChain 1404 22-41 48-57 86-105anti-HIV_V3_LightChain 1405 22-41 85-104 anti-HIV_V3_LightChain 140622-41 49-58 anti-HIV_V3_LightChain 1407 22-41 48-57 86-105anti-HIV_V3_LightChain 1408 22-41 85-104 anti-HIV_V3_LightChain 140922-41 47-56 85-104 anti-HIV_V3_LightChain 1410 22-41 47-56 85-104anti-HIV_CD4bs_LightChain 1411 22-41 90-109 anti-HIV_CD4bs_LightChain1412 22-41 49-58 87-106 anti-HIV_CD4bs_LightChain 1413 22-41 50-5988-107 anti-HIV_CD4bs_LightChain 1414 22-41 36-45 91-110anti-HIV_CD4bs_LightChain 1415 22-41 49-58 87-106anti-HIV_CD4bs_LightChain 1416 22-41 49-58 89-108anti-HIV_CD4bs_LightChain 1417 22-41 53-62 91-110anti-HIV_CD4bs_LightChain 1418 22-41 88-107 anti-HIV_CD4bs_LightChain1419 22-41 29-38 86-105 anti-HIV_CD4bs_LightChain 1420 22-41 88-107anti-HIV_V2_LightChain 1421 22-41 48-57 86-105 anti-HIV_V2_LightChain1422 22-41 48-57 86-105 anti-HIV_V2_LightChain 1423 22-41 50-59 88-107anti-HIV_V2_LightChain 1424 22-41 48-57 86-105 anti-HIV_V2_LightChain1425 22-41 49-58 87-106 anti-HIV_V2_LightChain 1426 22-41 48-57anti-HIV_10E8 1427 22-41 47-56 85-104 anti-HIV_10E8 1428 22-41 47-5685-104 anti-HIV_10E8 1429 22-41 47-56 85-104 anti-HIV_10E8 1430 22-4147-56 85-104 anti-HIV_10E8 1431 22-41 47-56 85-104 anti-HIV_10E8 143222-41 47-56 85-104 anti-HIV_10E8 1433 22-41 47-56 85-104 anti-HIV_10E81434 22-41 47-56 85-104 anti-HIV_10E8 1435 22-41 85-104 anti-HIV_10E81436 22-41 85-104 anti-HIV_10E8 1437 22-41 85-104 anti-HIV_10E8 143822-41 85-104 anti-HIV_10E8 1439 22-41 85-104 anti-HIV_10E8 1440 22-4185-104 anti-HIV_10E8 1441 22-41 85-104 anti-HIV_10E8 1442 22-41 85-104anti-HIV_10E8 1443 22-41 85-104 anti-HIV_10E8 1444 22-41 85-104anti-HIV_10E8 1445 22-41 85-104 anti-HIV_10E8 1446 22-41 anti-HIV_10E81447 22-41 85-104 anti-HIV_10E8 1448 22-41 85-104 anti-HIV_10E8 144922-41 96-115 anti-HIV_10E8 1450 22-41 anti-HIV_10E8 1451 22-41anti-HIV_10E8 1452 22-41 anti-HIV_10E8 1453 22-41 anti-HIV_10E8 145422-41 anti-HIV_10E8 1455 22-41 anti-HIV_10E8 1456 22-41 anti-HIV_10E81457 22-41 anti-HIV_10E8 1458 22-41 anti-HIV-1_LightChain 1459 22-4149-58 87-106 anti-HIV-1_LightChain 1460 22-41 50-59 88-107anti-HIV-1_LightChain 1461 22-41 45-54 83-102 anti-HIV-1_LightChain 146222-41 49-58 87-106 anti-HIV-1_LightChain 1463 22-41 49-58 87-106anti-HIV-1_LightChain 1464 22-41 87-106 anti-HIV-1_LightChain 1465 22-4149-58 87-106 anti-HIV-1_LightChain 1466 22-41 49-58 87-106anti-HIV-1_LightChain 1467 22-41 34-43 72-91  anti-HIV-1_LightChain 146822-41 87-106 anti-HIV-1_LightChain 1469 22-41 49-58 87-106anti-HIV-1_LightChain 1470 22-41 87-106 anti-HIV-1_LightChain 1471 22-4150-59 88-107 anti-HIV-1_LightChain 1472 22-41 87-106anti-HIV-1_LightChain 1473 22-41 50-59 88-107 anti-HIV-1_LightChain 147422-41 49-58 87-106 anti-HIV-1_LightChain 1475 22-41 49-58 87-106anti-HIV-1_LightChain 1476 22-41 49-58 87-106 anti-HIV-1_LightChain 147722-41 49-58 87-106 anti-HIV-1_LightChain 1478 22-41 49-58 87-106anti-HIV-1_LightChain 1479 22-41 50-59 88-107 anti-HIV-1_LightChain 148022-41 49-58 87-106 anti-HIV-1_LightChain 1481 22-41 87-106anti-HIV-1_LightChain 1482 22-41 49-58 87-106 anti-HIV-1_LightChain 148322-41 49-58 87-106 anti-HIV-1_LightChain 1484 22-41 49-58 87-106anti-HIV-1_LightChain 1485 22-41 50-59 88-107 anti-HIV-1_LightChain 148622-41 49-58 87-106 anti-HIV-1_LightChain 1487 22-41 87-106anti-HIV-1_LightChain 1488 22-41 49-58 87-106 anti-HIV-1_LightChain 148922-41 49-58 87-106 anti-HIV-1_LightChain 1490 22-41 49-58 87-106anti-HIV-1_LightChain 1491 22-41 87-106 anti-HIV-1_LightChain 1492 22-4149-58 87-106 anti-HIV-1_LightChain 1493 22-41 49-58 87-106anti-HIV-1_LightChain 1494 22-41 50-59 88-107 anti-HIV-1_LightChain 149522-41 49-58 87-106 anti-HIV-1_LightChain 1496 22-41 49-58 87-106anti-HIV-1_LightChain 1497 22-41 49-58 87-106 anti-HIV-1_LightChain 149822-41 49-58 87-106 anti-HIV-1_LightChain 1499 22-41 49-58 87-106anti-HIV-1_LightChain 1500 22-41 50-59 88-107 anti-HIV-1_LightChain 150122-41 49-58 87-106 anti-HIV-1_LightChain 1502 22-41 49-58 87-106anti-HIV-1_LightChain 1503 22-41 50-59 88-107 anti-HIV-1_LightChain 150422-41 49-58 87-106 anti-HIV-1_LightChain 1505 22-41 49-58 87-106anti-HIV-1_LightChain 1506 22-41 49-58 87-106 anti-HIV-1_LightChain 150722-41 49-58 87-106 anti-HIV-1_LightChain 1508 22-41 49-58 87-106anti-HIV-1_LightChain 1509 22-41 49-58 87-106 anti-HIV-1_LightChain 151022-41 49-58 87-106 anti-HIV-1_LightChain 1511 22-41 50-59 88-107anti-HIV-1_LightChain 1512 22-41 50-59 88-107 anti-HIV-1_LightChain 151322-41 49-58 87-106 anti-HIV-1_LightChain 1514 22-41 49-58 87-106anti-HIV-1_LightChain 1515 22-41 87-106 anti-HIV-1_LightChain 1516 22-4149-58 87-106 anti-HIV-1_LightChain 1517 22-41 49-58 87-106anti-HIV-1_LightChain 1518 22-41 49-58 87-106 anti-HIV-1_LightChain 151922-41 32-41 87-106 anti-HIV-1_LightChain 1520 22-41 49-58 87-106anti-HIV-1_LightChain 1521 22-41 50-59 88-107 anti-HIV-1_LightChain 152222-41 87-106 anti-HIV-1_LightChain 1523 22-41 49-58 87-106anti-HIV-1_LightChain 1524 22-41 49-58 87-106 anti-HIV-1_LightChain 152522-41 50-59 88-107 anti-HIV-1_LightChain 1526 22-41 87-106anti-HIV-1_LightChain 1527 22-41 49-58 87-106 anti-HIV-1_LightChain 152822-41 49-58 87-106 anti-HIV-1_LightChain 1529 22-41 87-106anti-HIV-1_LightChain 1530 22-41 87-106 anti-HIV-1_LightChain 1531 22-4149-58 87-106 anti-HIV-1_LightChain 1532 22-41 87-106anti-HIV-1_LightChain 1533 22-41 49-58 87-106 anti-HIV-1_LightChain 153422-41 49-58 87-106 anti-HIV-1_LightChain 1535 22-41 49-58 87-106anti-HIV-1_LightChain 1536 22-41 49-58 87-106 anti-HIV-1_LightChain 153722-41 49-58 87-106 anti-HIV-1_LightChain 1538 22-41 50-59 88-107anti-HIV-1_LightChain 1539 22-41 50-59 88-107 anti-HIV-1_LightChain 154022-41 87-106 anti-HIV-1_LightChain 1541 22-41 49-58 87-106anti-HIV-1_LightChain 1542 22-41 88-107 anti-HIV-1_LightChain 1543 22-4149-58 87-106 anti-HIV-1_LightChain 1544 22-41 49-58 87-106anti-HIV-1_LightChain 1545 22-41 49-58 87-106 anti-HIV-1_LightChain 154622-41 49-58 87-106 anti-HIV-1_LightChain 1547 22-41 87-106anti-HIV-1_LightChain 1548 22-41 87-106 anti-HIV-1_LightChain 1549 22-4150-59 88-107 anti-HIV-1_LightChain 1550 22-41 49-58 87-106anti-HIV-1_LightChain 1551 22-41 50-59 88-107 anti-HIV-1_LightChain 155222-41 49-58 87-106 anti-HIV-1_LightChain 1553 22-41 87-106anti-HIV-1_LightChain 1554 22-41 49-58 87-106 anti-HIV-1_LightChain 155522-41 50-59 88-107 anti-HIV-1_LightChain 1556 22-41 49-58 87-106anti-HIV-1_LightChain 1557 22-41 49-58 87-106 anti-HIV-1_LightChain 155822-41 49-58 87-106 anti-HIV-1_LightChain 1559 22-41 49-58 87-106anti-HIV-1_LightChain 1560 22-41 49-58 87-106 anti-HIV-1_LightChain 156122-41 49-58 87-106 anti-HIV-1_LightChain 1562 22-41 49-58 87-106anti-HIV-1_LightChain 1563 22-41 49-58 87-106 anti-HIV-1_LightChain 156422-41 49-58 87-106 anti-HIV-1_LightChain 1565 22-41 49-58 87-106anti-HIV-1_LightChain 1566 22-41 49-58 87-106 anti-HIV-1_LightChain 156722-41 49-58 87-106 anti-HIV-1_LightChain 1568 22-41 49-58 87-106anti-HIV-1_LightChain 1569 22-41 45-54 83-102 anti-HIV-1_LightChain 157022-41 49-58 87-106 anti-HIV-1_LightChain 1571 22-41 49-58 87-106anti-HIV-1_LightChain 1572 22-41 49-58 87-106 anti-HIV-1_LightChain 157322-41 50-59 88-107 anti-HIV-1_LightChain 1574 22-41 49-58 87-106anti-HIV-1_LightChain 1575 22-41 49-58 87-106 anti-HIV-1_LightChain 157622-41 49-58 87-106 anti-HIV-1_LightChain 1577 22-41 49-58 87-106anti-HIV-1_LightChain 1578 22-41 49-58 87-106 anti-HIV-1_LightChain 157922-41 32-41 87-106 anti-HIV-1_LightChain 1580 22-41 49-58 87-106anti-HIV-1_LightChain 1581 22-41 49-58 87-106 anti-HIV-1_LightChain 158222-41 50-59 88-107 anti-HIV-1_LightChain 1583 22-41 49-58 87-106anti-HIV-1_LightChain 1584 22-41 88-107 anti-HIV-1_LightChain 1585 22-4149-58 87-106 anti-HIV-1_LightChain 1586 22-41 49-58 87-106anti-HIV-1_LightChain 1587 22-41 45-54 83-102 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94-113anti-HIV_cap256-119-033789_VR-Chain 1939 22-41 63-82 anti-HIV_cap256-119-033641_VR-Chain 1940 22-41anti-HIV_cap256-119-032113_VR-Chain 1941 22-41 94-113anti-HIV_cap256-119-031739_VR-Chain 1942 22-41 94-113anti-HIV_cap256-119-030932_VR-Chain 1943 22-41 94-113anti-HIV_cap256-119-030740_VR-Chain 1944 22-41anti-HIV_cap256-119-030197_VR-Chain 1945 22-41 94-113anti-HIV_cap256-119-027047_VR-Chain 1946 22-41anti-HIV_cap256-119-026950_VR-Chain 1947 22-41 94-113anti-HIV_cap256-119-026279_VR-Chain 1948 22-41anti-HIV_cap256-119-025355_VR-Chain 1949 22-41anti-HIV_cap256-119-025301_VR-Chain 1950 22-41 94-113anti-HIV_cap256-119-025010_VR-Chain 1951 22-41anti-HIV_cap256-119-024631_VR-Chain 1952 22-41anti-HIV_cap256-119-024467_VR-Chain 1953 22-41 94-113anti-HIV_cap256-119-023805_VR-Chain 1954 22-41 94-113anti-HIV_cap256-119-021736_VR-Chain 1955 22-41 94-113anti-HIV_cap256-119-021203_VR-Chain 1956 22-41anti-HIV_cap256-119-020569_VR-Chain 1957 22-41 94-113anti-HIV_cap256-119-019432_VR-Chain 1958 22-41 94-113anti-HIV_cap256-119-018827_VR-Chain 1959 22-41 94-113anti-HIV_cap256-119-018483_VR-Chain 1960 22-41anti-HIV_cap256-119-018118_VR-Chain 1961 22-41 94-113anti-HIV_cap256-119-017782_VR-Chain 1962 22-41anti-HIV_cap256-119-017669_VR-Chain 1963 22-41 94-113anti-HIV_cap256-119-016976_VR-Chain 1964 22-41 94-113anti-HIV_cap256-119-015432_VR-Chain 1965 22-41 94-113anti-HIV_cap256-119-015281_VR-Chain 1966 22-41 94-113anti-HIV_cap256-119-014957_VR-Chain 1967 22-41 94-113anti-HIV_cap256-119-014777_VR-Chain 1968 22-41 94-113anti-HIV_cap256-119-014313_VR-Chain 1969 22-41anti-HIV_cap256-119-014219_VR-Chain 1970 22-41anti-HIV_cap256-119-013631_VR-Chain 1971 22-41anti-HIV_cap256-119-012924_VR-Chain 1972 22-41anti-HIV_cap256-119-011793_VR-Chain 1973 22-41 94-113anti-HIV_cap256-119-011413_VR-Chain 1974 22-41 94-113anti-HIV_cap256-119-011323_VR-Chain 1975 22-41 94-113anti-HIV_cap256-119-011233_VR-Chain 1976 22-41 94-113anti-HIV_cap256-119-009038_VR-Chain 1977 22-41 94-113anti-HIV_cap256-119-008756_VR-Chain 1978 22-41 94-113anti-HIV_cap256-119-008055_VR-Chain 1979 22-41anti-HIV_cap256-119-006949_VR-Chain 1980 22-41 94-113anti-HIV_cap256-119-006685_VR-Chain 1981 22-41anti-HIV_cap256-119-006015_VR-Chain 1982 22-41 94-113anti-HIV_cap256-119-005841_VR-Chain 1983 22-41 94-113anti-HIV_cap256-119-005824_VR-Chain 1984 22-41 94-113anti-HIV_cap256-119-005494_VR-Chain 1985 22-41 94-113anti-HIV_cap256-119-004949_VR-Chain 1986 22-41anti-HIV_cap256-119-004422_VR-Chain 1987 22-41 94-113anti-HIV_cap256-119-003932_VR-Chain 1988 22-41anti-HIV_cap256-119-003577_VR-Chain 1989 22-41anti-HIV_cap256-119-002155_VR-Chain 1990 22-41 94-113anti-HIV_cap256-119-002017_VR-Chain 1991 22-41anti-HIV_cap256-119-001312_VR-Chain 1992 22-41 94-113anti-HIV_cap256-119-001017_VR-Chain 1993 22-41anti-HIV_cap256-119-000594_VR-Chain 1994 22-41 94-113anti-HIV_cap256-059-241099_VR-Chain 1995 22-41 94-113anti-HIV_cap256-059-207529_VR-Chain 1996 22-41 94-113anti-HIV_cap256-059-205541_VR-Chain 1997 22-41 94-113anti-HIV_cap256-059-188439_VR-Chain 1998 22-41 94-113anti-HIV_cap256-059-187234_VR-Chain 1999 22-41 94-113anti-HIV_cap256-059-187047_VR-Chain 2000 22-41 94-113anti-HIV_cap256-059-186068_VR-Chain 2001 22-41 94-113anti-HIV_cap256-059-182835_VR-Chain 2002 22-41 94-113anti-HIV_cap256-059-176659_VR-Chain 2003 22-41 94-113anti-HIV_cap256-059-172956_VR-Chain 2004 22-41 94-113anti-HIV_cap256-059-171272_VR-Chain 2005 22-41 94-113anti-HIV_cap256-059-168734_VR-Chain 2006 22-41 94-113anti-HIV_cap256-059-155838_VR-Chain 2007 22-41 94-113anti-HIV_cap256-059-149799_VR-Chain 2008 22-41 94-113anti-HIV_cap256-059-148168_VR-Chain 2009 22-41anti-HIV_cap256-059-144685_VR-Chain 2010 22-41 94-113anti-HIV_cap256-059-140017_VR-Chain 2011 22-41 94-113anti-HIV_cap256-059-137547_VR-Chain 2012 22-41 94-113anti-HIV_cap256-059-131908_VR-Chain 2013 22-41 94-113anti-HIV_cap256-059-116006_VR-Chain 2014 22-41 94-113anti-HIV_cap256-059-115783_VR-Chain 2015 22-41 87-106anti-HIV_cap256-059-114609_VR-Chain 2016 22-41anti-HIV_cap256-059-113952_VR-Chain 2017 22-41 94-113anti-HIV_cap256-059-113878_VR-Chain 2018 22-41 94-113anti-HIV_cap256-059-113622_VR-Chain 2019 22-41 94-113anti-HIV_cap256-059-109427_VR-Chain 2020 22-41 94-113anti-HIV_cap256-059-109081_VR-Chain 2021 22-41 94-113anti-HIV_cap256-059-107590_VR-Chain 2022 22-41 94-113anti-HIV_cap256-059-107504_VR-Chain 2023 22-41 94-113anti-HIV_cap256-059-099614_VR-Chain 2024 22-41 94-113anti-HIV_cap256-059-098972_VR-Chain 2025 22-41 94-113anti-HIV_cap256-059-097236_VR-Chain 2026 22-41 94-113anti-HIV_cap256-059-091487_VR-Chain 2027 22-41 94-113anti-HIV_cap256-059-089812_VR-Chain 2028 22-41 94-113anti-HIV_cap256-059-088468_VR-Chain 2029 22-41 94-113anti-HIV_cap256-059-088341_VR-Chain 2030 22-41 94-113anti-HIV_cap256-059-086533_VR-Chain 2031 22-41 94-113anti-HIV_cap256-059-086043_VR-Chain 2032 22-41  93-102 94-113anti-HIV_cap256-059-084191_VR-Chain 2033 22-41 94-113anti-HIV_cap256-059-082135_VR-Chain 2034 22-41 94-113anti-HIV_cap256-059-079417_VR-Chain 2035 22-41 94-113anti-HIV_cap256-059-076027_VR-Chain 2036 22-41  93-102 94-113anti-HIV_cap256-059-075082_VR-Chain 2037 22-41 94-113anti-HIV_cap256-059-072575_VR-Chain 2038 22-41 94-113anti-HIV_cap256-059-071926_VR-Chain 2039 22-41 94-113anti-HIV_cap256-059-069638_VR-Chain 2040 22-41 94-113anti-HIV_cap256-059-069165_VR-Chain 2041 22-41 94-113anti-HIV_cap256-059-068956_VR-Chain 2042 22-41 94-113anti-HIV_cap256-059-068876_VR-Chain 2043 22-41 94-113anti-HIV_cap256-059-067733_VR-Chain 2044 22-41 94-113anti-HIV_cap256-059-067450_VR-Chain 2045 22-41 94-113anti-HIV_cap256-059-065694_VR-Chain 2046 22-41 94-113anti-HIV_cap256-059-065109_VR-Chain 2047 22-41 94-113anti-HIV_cap256-059-065060_VR-Chain 2048 22-41anti-HIV_cap256-059-064001_VR-Chain 2049 22-41 94-113anti-HIV_cap256-059-063270_VR-Chain 2050 22-41 94-113anti-HIV_cap256-059-061357_VR-Chain 2051 22-41 58-67anti-HIV_cap256-059-059834_VR-Chain 2052 22-41 94-113anti-HIV_cap256-059-059313_VR-Chain 2053 22-41 94-113anti-HIV_cap256-059-057130_VR-Chain 2054 22-41 94-113anti-HIV_cap256-059-050520_VR-Chain 2055 22-41 87-106anti-HIV_cap256-059-049839_VR-Chain 2056 22-41 94-113anti-HIV_cap256-059-048503_VR-Chain 2057 22-41 94-113anti-HIV_cap256-059-045516_VR-Chain 2058 22-41 94-113anti-HIV_cap256-059-044188_VR-Chain 2059 22-41 94-113anti-HIV_cap256-059-044105_VR-Chain 2060 22-41  93-102 94-113anti-HIV_cap256-059-042100_VR-Chain 2061 22-41anti-HIV_cap256-059-040742_VR-Chain 2062 22-41 94-113anti-HIV_cap256-059-040554_VR-Chain 2063 22-41 94-113anti-HIV_cap256-059-039660_VR-Chain 2064 22-41 94-113anti-HIV_cap256-059-039298_VR-Chain 2065 22-41 94-113anti-HIV_cap256-059-037873_VR-Chain 2066 22-41 94-113anti-HIV_cap256-059-037633_VR-Chain 2067 22-41 94-113anti-HIV_cap256-059-036817_VR-Chain 2068 22-41 94-113anti-HIV_cap256-059-032787_VR-Chain 2069 22-41 94-113anti-HIV_cap256-059-032427_VR-Chain 2070 22-41 94-113anti-HIV_cap256-059-029390_VR-Chain 2071 22-41 94-113anti-HIV_cap256-059-027877_VR-Chain 2072 22-41 94-113anti-HIV_cap256-059-026640_VR-Chain 2073 22-41  93-102 94-113anti-HIV_cap256-059-026017_VR-Chain 2074 22-41anti-HIV_cap256-059-024100_VR-Chain 2075 22-41 94-113anti-HIV_cap256-059-023966_VR-Chain 2076 22-41 94-113anti-HIV_cap256-059-020534_VR-Chain 2077 22-41 94-113anti-HIV_cap256-059-019513_VR-Chain 2078 22-41 94-113anti-HIV_cap256-059-012963_VR-Chain 2079 22-41 94-113anti-HIV_cap256-059-010396_VR-Chain 2080 22-41 94-113anti-HIV_cap256-059-008136_VR-Chain 2081 22-41anti-HIV_cap256-059-006147_VR-Chain 2082 22-41 94-113anti-HIV_cap256-059-005081_VR-Chain 2083 22-41 94-113anti-HIV_cap256-059-005006_VR-Chain 2084 22-41 94-113anti-HIV_cap256-059-004451_VR-Chain 2085 22-41 94-113anti-HIV_cap256-059-003571_VR-Chain 2086 22-41 94-113anti-HIV_cap256-059-003449_VR-Chain 2087 22-41 94-113anti-HIV_cap256-059-002712_VR-Chain 2088 22-41 94-113anti-HIV_cap256-059-001573_VR-Chain 2089 22-41 94-113anti-HIV_cap256-059-001379_VR-Chain 2090 22-41 94-113anti-HIV_cap256-059-001029_VR-Chain 2091 22-41 94-113anti-HIV_cap256-048-165087_VR-Chain 2092 22-41 94-113anti-HIV_cap256-048-158861_VR-Chain 2093 22-41 94-113anti-HIV_cap256-048-158280_VR-Chain 2094 22-41 20-29 94-113anti-HIV_cap256-048-157928_VR-Chain 2095 22-41 94-113anti-HIV_cap256-048-157056_VR-Chain 2096 22-41 94-113anti-HIV_cap256-048-156422_VR-Chain 2097 22-41 94-113anti-HIV_cap256-048-152863_VR-Chain 2098 22-41 94-113anti-HIV_cap256-048-152770_VR-Chain 2099 22-41 94-113anti-HIV_cap256-048-150027_VR-Chain 2100 22-41 94-113anti-HIV_cap256-048-148246_VR-Chain 2101 22-41 94-113anti-HIV_cap256-048-147428_VR-Chain 2102 22-41 94-113anti-HIV_cap256-048-146603_VR-Chain 2103 22-41anti-HIV_cap256-048-145735_VR-Chain 2104 22-41 94-113anti-HIV_cap256-048-145116_VR-Chain 2105 22-41 94-113anti-HIV_cap256-048-144077_VR-Chain 2106 22-41 94-113anti-HIV_cap256-048-142876_VR-Chain 2107 22-41anti-HIV_cap256-048-140582_VR-Chain 2108 22-41 94-113anti-HIV_cap256-048-139355_VR-Chain 2109 22-41 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2598 22-41 49-58 87-106anti-HIV_048-213230_VR-Chain 2599 22-41 49-58 87-106anti-HIV_048-212574_VR-Chain 2600 22-41 49-58 87-106anti-HIV_048-212207_VR-Chain 2601 22-41 49-58 87-106anti-HIV_048-209146_VR-Chain 2602 22-41 87-106anti-HIV_048-208206_VR-Chain 2603 22-41 49-58 87-106anti-HIV_048-208194_VR-Chain 2604 22-41 87-106anti-HIV_048-207744_VR-Chain 2605 22-41 49-58 87-106anti-HIV_048-206501_VR-Chain 2606 22-41 49-58 87-106anti-HIV_048-204221_VR-Chain 2607 22-41 49-58 87-106anti-HIV_048-204015_VR-Chain 2608 22-41 49-58 87-106anti-HIV_048-201240_VR-Chain 2609 22-41 87-106anti-HIV_048-200455_VR-Chain 2610 22-41 49-58 87-106anti-HIV_048-200319_VR-Chain 2611 22-41 49-58 87-106anti-HIV_048-197896_VR-Chain 2612 22-41 87-106anti-HIV_048-193813_VR-Chain 2613 22-41 49-58 87-106anti-HIV_048-192098_VR-Chain 2614 22-41 49-58 87-106anti-HIV_048-191786_VR-Chain 2615 22-41 49-58 87-106anti-HIV_048-188746_VR-Chain 2616 22-41 49-58 87-106anti-HIV_048-185937_VR-Chain 2617 22-41 49-58 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2637 22-41 49-58 87-106anti-HIV_048-159333_VR-Chain 2638 22-41 49-58 87-106anti-HIV_048-158932_VR-Chain 2639 22-41 49-58 87-106anti-HIV_048-155811_VR-Chain 2640 22-41 87-106anti-HIV_048-155464_VR-Chain 2641 22-41 49-58 87-106anti-HIV_048-155392_VR-Chain 2642 22-41 87-106anti-HIV_048-155389_VR-Chain 2643 22-41 49-58 87-106anti-HIV_048-154449_VR-Chain 2644 22-41 49-58 87-106anti-HIV_048-153379_VR-Chain 2645 22-41 49-58 87-106anti-HIV_048-153171_VR-Chain 2646 22-41 32-41 87-106anti-HIV_048-152324_VR-Chain 2647 22-41 49-58 87-106anti-HIV_048-146102_VR-Chain 2648 22-41 49-58 87-106anti-HIV_048-145984_VR-Chain 2649 22-41 87-106anti-HIV_048-145371_VR-Chain 2650 22-41 49-58 87-106anti-HIV_048-144907_VR-Chain 2651 22-41 49-58 87-106anti-HIV_048-142298_VR-Chain 2652 22-41 87-106anti-HIV_048-142277_VR-Chain 2653 22-41 49-58 87-106anti-HIV_048-141934_VR-Chain 2654 22-41 49-58 87-106anti-HIV_048-141207_VR-Chain 2655 22-41 49-58 87-106anti-HIV_048-140796_VR-Chain 2656 22-41 49-58 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anti-HIV-1_LightChain 2814 22-41anti-HIV-1_LightChain 2815 22-41 anti-HIV-1_LightChain 2816 22-41anti-HIV-1_LightChain 2817 22-41 anti-HIV-1_LightChain 2818 22-41anti-HIV-1_LightChain 2819 22-41 anti-HIV-1_LightChain 2820 22-41anti-HIV-1_HeavyChain 2821 22-41 74-83 anti-HIV-1_HeavyChain 2822 22-4174-83 anti-HIV-1_HeavyChain 2823 22-41 anti-HIV-1_HeavyChain 2824 22-4174-83 94-113 anti-HIV-1_HeavyChain 2825 22-41 74-83anti-HIV-1_HeavyChain 2826 22-41 74-83 94-113 anti-HIV-1_HeavyChain 282722-41 anti-HIV-1_HeavyChain 2828 22-41 74-83 94-113anti-HIV-1_HeavyChain 2829 22-41 74-83 anti-HIV-1_HeavyChain 2830 22-41anti-HIV-1_HeavyChain 2831 22-41 86-105 anti-HIV-1_HeavyChain 2832 22-4186-105 anti-HIV-1_HeavyChain 2833 22-41 86-105 anti-HIV-1_HeavyChain2834 22-41 86-105 anti-HIV-1_HeavyChain 2835 22-41 anti-HIV-1_HeavyChain2836 22-41 86-105 anti-HIV-1_HeavyChain 2837 22-41 100-119 anti-HIV-1_HeavyChain 2838 22-41 100-119  anti-HIV-1_HeavyChain 283922-41 100-119  anti-HIV-1_HeavyChain 2840 22-41 100-119 anti-HIV-1_HeavyChain 2841 22-41 100-119  anti-HIV-1_HeavyChain 284222-41 100-119  anti-HIV-1_HeavyChain 2843 22-41 100-119 anti-HIV-1_HeavyChain 2844 22-41 100-119  anti-HIV-1_HeavyChain 284522-41 100-119  anti-HIV-1_HeavyChain 2846 22-41 anti-HIV-1_HeavyChain2847 22-41 anti-HIV-1_LightChain 2848 22-41 46-55 84-101anti-HIV-1_HeavyChain 2849 22-41 anti-HIV-1_HeavyChain 2850 22-41anti-HIV-1_HeavyChain 2851 22-41 35-44 anti-HIV-1_HeavyChain 2852 22-4135-44 anti-HIV-1_HeavyChain 2853 22-41 35-44 anti-HIV-1_HeavyChain 285422-41 35-44 anti-HIV-1_HeavyChain 2855 22-41 35-44 anti-HIV-1_HeavyChain2856 22-41 anti-HIV-1_HeavyChain 2857 22-41 anti-HIV-1_HeavyChain 285822-41 anti-HIV-1_HeavyChain 2859 22-41 anti-HIV-1_HeavyChain 2860 22-41anti-HIV-1_HeavyChain 2861 22-41  95-104 anti-HIV-1_HeavyChain 286222-41 anti-HIV-1_HeavyChain 2863 22-41 anti-HIV-1_HeavyChain 2864 22-41anti-HIV-1_HeavyChain 2865 22-41 anti-HIV-1_HeavyChain 2866 22-41 34-43anti-HIV-1_HeavyChain 2867 22-41 anti-HIV-1_HeavyChain 2868 22-41anti-HIV-1_HeavyChain 2869 22-41 anti-HIV-1_HeavyChain 2870 22-41anti-HIV-1_HeavyChain 2871 22-41 95-114 anti-HIV-1_HeavyChain 2872 22-4135-44 anti-HIV-1_HeavyChain 2873 22-41 anti-HIV-1_HeavyChain 2874 22-41anti-HIV-1_HeavyChain 2875 22-41 anti-HIV-1_HeavyChain 2876 22-41anti-HIV-1_HeavyChain 2877 22-41 96-115 anti-HIV-1_HeavyChain 2878 22-41anti-HIV-1_HeavyChain 2879 22-41 anti-HIV-1_HeavyChain 2880 22-41anti-HIV-1_HeavyChain 2881 22-41 anti-HIV-1_HeavyChain 2882 22-41anti-HIV-1_HeavyChain 2883 22-41 anti-HIV-1_HeavyChain 2884 22-41 35-44anti-HIV-1_HeavyChain 2885 22-41 anti-HIV-1_HeavyChain 2886 22-41 96-115anti-HIV-1_HeavyChain 2887 22-41 anti-HIV-1_HeavyChain 2888 22-41anti-HIV-1_HeavyChain 2889 22-41 34-43 anti-HIV-1_HeavyChain 2890 22-41anti-HIV-1_HeavyChain 2891 22-41 anti-HIV-1_HeavyChain 2892 22-41 34-43anti-HIV-1_HeavyChain 2893 22-41 34-43 anti-HIV-1_HeavyChain 2894 22-41anti-HIV-1_HeavyChain 2895 22-41 anti-HIV-1_HeavyChain 2896 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22-41 93-102 94-113 anti-HIV-1_HeavyChain 3918 22-41 anti-HIV-1_HeavyChain3919 22-41 anti-HIV-1_HeavyChain 3920 22-41 anti-HIV-1_HeavyChain 392122-41 anti-HIV-1_HeavyChain 3922 22-41 anti-HIV-1_HeavyChain 3923 22-41anti-HIV-1_HeavyChain 3924 22-41 anti-HIV-1_HeavyChain 3925 22-41anti-HIV-1_HeavyChain 3926 22-41 35-44 anti-HIV-1_HeavyChain 3927 22-4135-44 anti-HIV-1_HeavyChain 3928 22-41 anti-HIV-1_HeavyChain 3929 22-41anti-HIV-1_HeavyChain 3930 22-41 anti-HIV-1_HeavyChain 3931 22-41 35-44anti-HIV-1_HeavyChain 3932 22-41 anti-HIV-1_HeavyChain 3933 22-41 35-44anti-HIV-1_HeavyChain 3934 22-41 35-44 anti-HIV-1_HeavyChain 3935 22-41anti-HIV-1_HeavyChain 3936 22-41 35-44 anti-HIV-1_HeavyChain 3937 22-41anti-HIV-1_HeavyChain 3938 22-41 anti-HIV-1_HeavyChain 3939 22-41anti-HIV-1_HeavyChain 3940 22-41 anti-HIV-1_HeavyChain 3941 22-41anti-HIV-1_HeavyChain 3942 22-41  95-104 anti-HIV-1_HeavyChain 394322-41  95-104 anti-HIV-1_HeavyChain 3944 22-41 anti-HIV-1_HeavyChain3945 22-41 anti-HIV-1_HeavyChain 3946 22-41 35-44 anti-HIV-1_HeavyChain3947 22-41 anti-HIV-1_HeavyChain 3948 22-41 anti-HIV-1_HeavyChain 394922-41 anti-HIV-1_HeavyChain 3950 22-41 anti-HIV-1_HeavyChain 3951 22-41anti-HIV-1_HeavyChain 3952 22-41 anti-HIV-1_HeavyChain 3953 22-41anti-HIV-1_HeavyChain 3954 22-41 anti-HIV-1_HeavyChain 3955 22-41anti-HIV-1_HeavyChain 3956 22-41 anti-HIV-1_HeavyChain 3957 22-41anti-HIV-1_HeavyChain 3958 22-41 anti-HIV-1_HeavyChain 3959 22-41anti-HIV-1_HeavyChain 3960 22-41 anti-HIV-1_HeavyChain 3961 22-41anti-HIV-1_HeavyChain 3962 22-41 anti-HIV-1_HeavyChain 3963 22-41 96-115anti-HIV-1_HeavyChain 3964 22-41 anti-HIV-1_HeavyChain 3965 22-41anti-HIV-1_HeavyChain 3966 22-41 anti-HIV-1_HeavyChain 3967 22-41anti-HIV-1_HeavyChain 3968 22-41 anti-HIV-1_HeavyChain 3969 22-41 96-115anti-HIV-1_HeavyChain 3970 22-41 96-115 anti-HIV-1_HeavyChain 3971 22-4196-115 anti-HIV-1_HeavyChain 3972 22-41 anti-HIV-1_HeavyChain 3973 22-4195-114 anti-HIV-1_HeavyChain 3974 22-41 anti-HIV-1_HeavyChain 3975 22-4196-115 anti-HIV-1_HeavyChain 3976 22-41 anti-HIV-1_HeavyChain 3977 22-4196-115 anti-HIV-1_HeavyChain 3978 22-41 anti-HIV-1_HeavyChain 3979 22-4196-115 anti-HIV-1_HeavyChain 3980 22-41 anti-HIV-1_HeavyChain 3981 22-41anti-HIV-1_HeavyChain 3982 22-41 anti-HIV-1_HeavyChain 3983 22-41 96-115anti-HIV-1_HeavyChain 3984 22-41 anti-HIV-1_HeavyChain 3985 22-41anti-HIV-1_HeavyChain 3989 22-41 96-115 anti-HIV-1_HeavyChain 3987 22-41anti-HIV-1_HeavyChain 3988 22-41 96-115 anti-HIV-1_HeavyChain 3989 22-4195-114 anti-HIV-1_HeavyChain 3990 22-41 anti-HIV-1_HeavyChain 3991 22-41anti-HIV-1_HeavyChain 3992 22-41 anti-HIV-1_HeavyChain 3993 22-41anti-HIV-1_HeavyChain 3994 22-41 96-115 anti-HIV-1_HeavyChain 3995 22-41anti-HIV-1_HeavyChain 3996 22-41 96-115 anti-HIV-1_HeavyChain 3997 22-4196-115 anti-HIV-1_HeavyChain 3998 22-41 anti-HIV-1_HeavyChain 3999 22-4195-114 anti-HIV-1_HeavyChain 4000 22-41 anti-HIV_5CIN_LightChain 400122-41 49-58 87-106 anti-HIV_5CIN_HeavyChain 4002 22-41 93-112anti-HIV_5CIL_HeavyChain 4003 22-41 93-112 anti-HIV_5CIP_A-Chain 400422-41 93-112 anti-HIV_5CIP_HeavyChain 4005 22-41 93-112anti-HIV_4JKP_LightChain 4006 22-41 46-55 84-103 anti-HIV_3TNN_E-Chain4007 22-41 94-113 anti-HIV_3BQU_B-Chain 4008 22-41 53-62anti-HIV_3BQU_A-Chain 4009 22-41 48-57 89-105 anti-HIV_1gG_VR-Chain 401022-41 69-78 107-126  anti-HIV_1gG_HeavyChain 4011 22-41 70-79 112-116 anti-HIV_4P9M_HeavyChain 4012 22-41 anti-HIV_4P9M_LightChain 4013 22-4149-58 anti-HIV_4P9H_C-Chain 4014 22-41 anti-HIV_4YBL_A-Chain 4015 22-41anti-HIV_4R4N_V-Chain 4016 22-41 294-303 anti-HIV_4JKP_G-Chain 401722-41 anti-HIV_3BQU_D-Chain 4018 22-41 113-132  anti-HIV_3BQU_C-Chain4019 22-41 108-127  anti-HIV_1g_LightChain 4020 22-41 90-109anti-HIV_1g_HeavyChain 4021 22-41 94-113 anti-HIV_4P9H_G-Chain 402222-41 anti-HIV_Chain 4023 22-41 anti-HIV_Chain 4024 22-41 anti-HIV_Chain4025 22-41 anti-HIV_Chain 4026 22-41 53-62 anti-HIV_Chain 4027 22-4165-84 anti-HIV_Chain 4028 22-41 67-86 anti-HIV_Chain 4029 22-41 65-84anti-HIV_Chain 4030 22-41 anti-HIV_Chain 4031 22-41 anti-HIV_Chain 403222-41 anti-HIV_Chain 4033 22-41 82-100 anti-HIV_Chain 4034 22-41 82-100anti-HIV_Chain 4035 22-41 82-100 anti-HIV_Chain 4036 22-41anti-HIV_Chain 4037 22-41 anti-HIV_Chain 4038 22-41 anti-HIV_Chain 403922-41 84-102 anti-HIV_Chain 4040 22-41 84-102 anti-HIV_Chain 4041 22-4182-101 anti-HIV_Chain 4042 22-41 anti-HIV_Chain 4043 22-41 44-53anti-HIV_Chain 4044 22-41 44-53 anti-HIV_Chain 4045 22-41 44-53anti-HIV_Chain 4046 22-41 44-53 anti-HIV_Chain 4047 22-41 44-53anti-HIV_Chain 4048 22-41 44-53 anti-HIV_Chain 4049 22-41 83-102anti-HIV_Chain 4050 22-41 83-102 anti-HIV_Chain 4051 22-41 44-53anti-HIV_Chain 4052 22-41 71-80 72-91  anti-HIV_Chain 4053 22-41anti-HIV_Chain 4054 22-41 40-49 81-100 anti-HIV_Chain 4055 22-41 40-4981-100 anti-HIV_Chain 4056 22-41 40-49 81-100 anti-HIV_Chain 4057 22-4181-100 anti-HIV_Chain 4058 22-41 83-102 anti-HIV_Chain 4059 22-41anti-HIV_Chain 4060 22-41 32-41 74-93  anti-HIV_Chain 4061 22-41 42-5183-102 anti-HIV_Chain 4062 22-41 42-51 83-102 anti-HIV_Chain 4063 22-41anti-HIV_Chain 4064 22-41 anti-HIV_Chain 4065 22-41 anti-HIV_Chain 406622-41 anti-HIV_Chain 4067 22-41 46-55 84-103 anti-HIV_Chain 4068 22-41anti-HIV_Chain 4069 22-41 anti-HIV_Chain 4070 22-41 43-52 84-103anti-HIV_LightChain 4071 22-41 48-57 86-105 anti-HIV_LightChain 407222-41 48-57 86-105 anti-HIV_Chain 4073 22-41 83-102 anti-HIV_Chain 407422-41 38-47 76-95  anti-HIV_Chain 4075 22-41 47-56 85-104anti-HIV_HeavyChain 4076 22-41 anti-HIV_Chain 4077 22-41 47-56 85-104anti-HIV_Chain 4078 22-41 38-47 anti-HIV_LightChain 4079 22-41 54-6392-111 anti-HIV_LightChain 4080 22-41 48-57 86-105 anti-HIV_Chain 408122-41 44-53 anti-HIV_Chain 4082 22-41 49-58 87-106 anti-HIV_Chain 408322-41 77-96  anti-HIV_Chain 4084 22-41 44-53 anti-HIV_Chain 4085 22-4144-53 anti-HIV_Chain 4086 22-41 44-53 anti-HIV_Chain 4087 22-41 44-53anti-HIV_Chain 4088 22-41 anti-HIV_Chain 4089 22-41 44-53 anti-HIV_Chain4090 22-41 44-53 anti-HIV_Chain 4091 22-41 44-53 anti-HIV_Chain 409222-41 44-53 anti-HIV_Chain 4093 22-41 44-53 anti-HIV_Chain 4094 22-4144-53 anti-HIV_Chain 4095 22-41 51-60 89-108 anti-HIV_Chain 4096 22-4183-102 anti-HIV_Chain 4097 22-41 83-102 anti-HIV_Chain 4098 22-41 83-102anti-HIV_Chain 4099 22-41 83-102 anti-HIV_Chain 4100 22-41 83-102anti-HIV_Chain 4101 22-41 83-102 anti-HIV_Chain 4102 22-41 83-102anti-HIV_Chain 4103 22-41 83-102 anti-HIV_Chain 4104 22-41 83-102anti-HIV_Chain 4105 22-41 83-102 anti-HIV_Chain 4106 22-41 41-50 79-98 anti-HIV_Chain 4107 22-41 39-48 77-96  anti-HIV_Chain 4108 22-41 49-58anti-HIV_Chain 4109 22-41 41-50 83-102 anti-HIV_Chain 4110 22-41 79-8880-99  anti-HIV_Chain 4111 22-41 42-51 anti-HIV_Chain 4112 22-41 42-5180-99  anti-HIV_LightChain 4113 22-41 49-58 anti-HIV_LightChain 411422-41 49-58 anti-HIV_LightChain 4115 22-41 49-58 anti-HIV_LightChain4116 22-41 49-58 anti-HIV_LightChain 4117 22-41 49-58anti-HIV_LightChain 4118 22-41 49-58 anti-HIV_LightChain 4119 22-4149-58 anti-HIV_LightChain 4120 22-41 49-58 anti-HIV_LightChain 412122-41 49-58 anti-HIV_LightChain 4122 22-41 49-58 anti-HIV_LightChain4123 22-41 49-58 anti-HIV_LightChain 4124 22-41 49-58anti-HIV_LightChain 4125 22-41 49-58 anti-HIV_LightChain 4126 22-4149-58 anti-HIV_LightChain 4127 22-41 49-58 anti-HIV_Chain 4128 22-41102-117  anti-HIV_Chain 4129 22-41 41-50 79-98  anti-HIV_Chain 413022-41 anti-HIV_Chain 4131 22-41 anti-HIV_Chain 4132 22-41 anti-HIV_Chain4133 22-41 82-101 anti-HIV_Chain 4134 22-41 anti-HIV_Chain 4135 22-4143-52 anti-HIV_Chain 4136 22-41 anti-HIV_HeavyChain 4137 22-41 51-60anti-HIV_Chain 4138 22-41 34-43 anti-HIV_Chain 4139 22-41 34-43anti-HIV_Chain 4140 22-41 88-107 anti-HIV_Chain 4141 22-41 49-58 87-106anti-HIV_Chain 4142 22-41 38-47 76-95  anti-HIV_Chain 4143 22-41anti-HIV_Chain 4144 22-41 anti-HIV_Chain 4145 22-41 50-59 88-107anti-HIV_Chain 4146 22-41 50-59 88-107 anti-HIV_Chain 4147 22-41anti-HIV_Chain 4148 22-41 anti-HIV_Chain 4149 22-41 anti-HIV_Chain 415022-41 anti-HIV_Chain 4151 22-41 anti-HIV_Chain 4152 22-41 anti-HIV_Chain4153 22-41 anti-HIV_Chain 4154 22-41 anti-HIV_Chain 4155 22-41 48-57anti-HIV_Chain 4156 22-41 anti-HIV_Chain 4157 22-41  94-103 95-114anti-HIV_HeavyChain 4158 22-41 94-113 anti-HIV_HeavyChain 4159 22-4194-113 anti-HIV_Chain 4160 22-41 48-57 anti-HIV_Chain 4161 22-41 48-57anti-HIV_Chain 4162 22-41 anti-HIV_Chain 4163 22-41 48-57 86-105anti-HIV_Chain 4164 22-41 anti-HIV_Chain 4165 22-41 51-60 anti-HIV_Chain4166 22-41 94-113 anti-HIV_Chain 4167 22-41  95-104 96-115anti-HIV_Chain 4168 22-41 74-83 anti-HIV_Chain 4169 22-41 48-57 86-105anti-HIV_Chain 4170 22-41 49-58 87-106 anti-HIV_Chain 4171 22-41 48-5786-105 anti-HIV_Chain 4172 22-41 48-57 anti-HIV_Chain 4173 22-41anti-HIV_Chain 4174 22-41 anti-HIV_Chain 4175 22-41 anti-HIV_Chain 417622-41 59-68 94-113 anti-HIV_Chain 4177 22-41 94-113 anti-HIV_Chain 417822-41 94-113 anti-HIV_Chain 4179 22-41 94-113 anti-HIV_Chain 4180 22-41 97-106 anti-HIV_Chain 4181 22-41  97-106 anti-HIV_Chain 4182 22-41 97-106 anti-HIV_Chain 4183 22-41 anti-HIV_Chain 4184 22-41anti-HIV_Chain 4185 22-41 anti-HIV_Chain 4186 22-41 51-60 93-112anti-HIV_Chain 4187 22-41 51-60 anti-HIV_Chain 4188 22-41 48-57 86-105anti-HIV_Chain 4189 22-41 anti-HIV_Chain 4190 22-41 48-57 86-105anti-HIV_Chain 4191 22-41 48-57 86-105 anti-HIV_Chain 4192 22-41 49-5887-106 anti-HIV_Chain 4193 22-41 anti-HIV_Chain 4194 22-41anti-HIV_Chain 4195 22-41 84-93 85-104 anti-HIV_Chain 4196 22-41 47-5685-104 anti-HIV_Chain 4197 22-41 47-56 85-104 anti-HIV_Chain 4198 22-4184-93 85-104 anti-HIV_Chain 4199 22-41 85-104 anti-HIV_Chain 4200 22-4184-93 85-104 anti-HIV_Chain 4201 22-41  93-102 94-113 anti-HIV_Chain4202 22-41 94-113 anti-HIV_Chain 4203 22-41 94-113 anti-HIV_Chain 420422-41 91-110 anti-HIV_Chain 4205 22-41 94-113 anti-HIV_HeavyChain 420622-41 51-60 94-113 anti-HIV_Chain 4207 22-41 anti-HIV_Chain 4208 22-41anti-HIV_Chain 4209 22-41 58-67 94-113 anti-HIV_Chain 4210 22-41 48-5786-105 anti-HIV_Chain 4211 22-41 49-58 87-106 anti-HIV_Chain 4212 22-4149-58 87-106 anti-HIV_Chain 4213 22-41 85-104 anti-HIV_Chain 4214 22-41anti-HIV_Chain 4215 22-41 anti-HIV_Chain 4216 22-41 48-57 anti-HIV_Chain4217 22-41 34-43 anti-HIV_Chain 4218 22-41 34-43 anti-HIV_Chain 421922-41 34-43 anti-HIV_Chain 4220 22-41 34-43 anti-HIV_Chain 4221 22-4134-43 anti-HIV_Chain 4222 22-41 34-43 anti-HIV_Chain 4223 22-41 34-43anti-HIV_Chain 4224 22-41 34-43 anti-HIV_Chain 4225 22-41  93-102anti-HIV_Chain 4226 22-41 34-43 anti-HIV_Chain 4227 22-41 34-43anti-HIV_Chain 4228 22-41 34-43 anti-HIV_Chain 4229 22-41  93-102anti-HIV_Chain 4230 22-41 34-43 anti-HIV_Chain 4231 22-41 34-43anti-HIV_Chain 4232 22-41 34-43 anti-HIV_Chain 4233 22-41  93-102anti-HIV_Chain 4234 22-41 94-113 anti-HIV_Chain 4235 22-41 58-67 94-113anti-HIV_Chain 4236 22-41 94-113 anti-HIV_Chain 4237 22-41anti-HIV_Chain 4238 22-41 94-113 anti-HIV_Chain 4239 22-41anti-HIV_Chain 4240 22-41 anti-HIV_Chain 4241 22-41 94-113anti-HIV_Chain 4242 22-41 94-113 anti-HIV_Chain 4243 22-41 96-115anti-HIV_Chain 4244 22-41 48-57 86-105 anti-HIV_Chain 4245 22-41 50-5988-107 anti-HIV_Chain 4246 22-41 anti-HIV_Chain 4247 22-41 49-58anti-HIV_Chain 4248 22-41 48-57 86-105 anti-HIV_Chain 4249 22-41 35-44anti-HIV_Chain 4250 22-41  93-102 anti-HIV_Chain 4251 22-41 94-113anti-HIV_Chain 4252 22-41 95-114 anti-HIV_Chain 4253 22-41anti-HIV_Chain 4254 22-41 anti-HIV_Chain 4255 22-41 anti-HIV_Chain 425622-41 51-60 93-112 anti-HIV_Chain 4257 22-41  92-101 93-112anti-HIV_Chain 4258 22-41 93-112 anti-HIV_Chain 4259 22-41 93-112anti-HIV_Chain 4260 22-41 94-113 anti-HIV_Chain 4261 22-41anti-HIV_Chain 4262 22-41 94-113 anti-HIV_Chain 4263 22-41 53-62 95-114anti-HIV_Chain 4264 22-41 anti-HIV_Chain 4265 22-41 94-113anti-HIV_Chain 4266 22-41 94-113 anti-HIV_Chain 4267 22-41anti-HIV_Chain 4268 22-41 51-60 93-112 anti-HIV_Chain 4269 22-41 94-113anti-HIV_Chain 4270 22-41 94-113 anti-HIV_Chain 4271 22-41 94-113anti-HIV_Chain 4272 22-41 49-58 87-106 anti-HIV_Chain 4273 22-41 49-5887-106 anti-HIV_Chain 4274 22-41 49-58 87-106 anti-HIV_Chain 4275 22-41 93-102 94-113 anti-HIV_Chain 4276 22-41 anti-HIV_Chain 4277 22-41anti-HIV_Chain 4278 22-41 88-107 anti-HIV_Chain 4279 22-41  93-10294-113 anti-HIV_Chain 4280 22-41  93-102 94-113 anti-HIV_Chain 428122-41  93-102 94-113 anti-HIV_Chain 4282 22-41 94-113 anti-HIV_Chain4283 22-41 93-112 anti-HIV_Chain 4284 22-41 94-113 anti-HIV_Chain 428522-41 94-113 anti-HIV_Chain 4286 22-41 anti-HIV_Chain 4287 22-41anti-HIV_Chain 4288 22-41 94-113 anti-HIV_Chain 4289 22-41 94-113anti-HIV_Chain 4290 22-41 58-67 94-113 anti-HIV_Chain 4291 22-41anti-HIV_Chain 4292 22-41 93-112 anti-HIV_Chain 4293 22-41  93-10294-113 anti-HIV_Chain 4294 22-41 49-58 87-106 anti-HIV_Chain 4295 22-41anti-HIV_Chain 4296 22-41 anti-HIV_Chain 4297 22-41 anti-HIV_Chain 429822-41 anti-HIV_Chain 4299 22-41  93-102 94-113 anti-HIV_Chain 4300 22-4153-62 95-114 anti-HIV_Chain 4301 22-41 94-113 anti-HIV_Chain 4302 22-4193-112 anti-HIV_Chain 4303 22-41 anti-HIV_Chain 4304 22-41 74-83 94-113anti-HIV_Chain 4305 22-41 anti-HIV_Chain 4306 22-41 74-83 anti-HIV_Chain4307 22-41 74-83 anti-HIV_Chain 4308 22-41 94-113 anti-HIV_Chain 430922-41 94-113 anti-HIV_Chain 4310 22-41 94-113 anti-HIV_Chain 4311 22-4174-83 anti-HIV_Chain 4312 22-41 74-83 anti-HIV_Chain 4313 22-41 74-83anti-HIV_Chain 4314 22-41 74-83 94-113 anti-HIV_Chain 4315 22-41 83-9294-113 anti-HIV_Chain 4316 22-41 53-62 95-114 anti-HIV_Chain 4317 22-41 93-102 94-113 anti-HIV_Chain 4318 22-41 28-37 anti-HIV_Chain 4319 22-4193-112 anti-HIV_Chain 4320 22-41 anti-HIV_Chain 4321 22-41 49-58anti-HIV_Chain 4322 22-41 anti-HIV_Chain 4323 22-41 anti-HIV_Chain 432422-41 anti-HIV_Chain 4325 22-41  97-106 anti-HIV_Chain 4326 22-41anti-HIV_Chain 4327 22-41 anti-HIV_Chain 4328 22-41 anti-HIV_Chain 432922-41  97-106 anti-HIV_Chain 4330 22-41  97-106 anti-HIV_Chain 433122-41 anti-HIV_Chain 4332 22-41  97-106 anti-HIV_Chain 4333 22-41anti-HIV_Chain 4334 22-41  97-106 anti-HIV_Chain 4335 22-41anti-HIV_Chain 4336 22-41 anti-HIV_Chain 4337 22-41 anti-HIV_Chain 433822-41 anti-HIV_Chain 4339 22-41 anti-HIV_Chain 4340 22-41 anti-HIV_Chain4341 22-41  97-106 anti-HIV_Chain 4342 22-41 anti-HIV_Chain 4343 22-41anti-HIV_Chain 4344 22-41 anti-HIV_Chain 4345 22-41 anti-HIV_Chain 434622-41 anti-HIV_Chain 4347 22-41 anti-HIV_Chain 4348 22-41 anti-HIV_Chain4349 22-41 anti-HIV_Chain 4350 22-41 anti-HIV_Chain 4351 22-41anti-HIV_Chain 4352 22-41 96-115 anti-HIV_Chain 4353 22-41 94-113anti-HIV_Chain 4354 22-41 94-113 anti-HIV_Chain 4355 22-41 96-115anti-HIV_Chain 4356 22-41  92-101 anti-HIV_Chain 4357 22-41anti-HIV_Chain 4358 22-41 93-112 anti-HIV_Chain 4359 22-41  93-102anti-HIV_Chain 4360 22-41 94-113 anti-HIV_Chain 4361 22-41anti-HIV_Chain 4362 22-41 anti-HIV_Chain 4363 22-41 93-112anti-HIV_Chain 4364 22-41 94-113 anti-HIV_Chain 4365 22-41 94-113anti-HIV_Chain 4366 22-41 59-68 94-113 anti-HIV_Chain 4367 22-41 59-6894-113 anti-HIV_Chain 4368 22-41 94-113 anti-HIV_Chain 4369 22-41 94-113anti-HIV_Chain 4370 22-41 94-113 anti-HIV_Chain 4371 22-41 94-113anti-HIV_Chain 4372 22-41 94-113 anti-HIV_Chain 4373 22-41 94-113anti-HIV_Chain 4374 22-41 94-113 anti-HIV_Chain 4375 22-41 93-112anti-HIV_Chain 4376 22-41 50-59 88-107 anti-HIV_Chain 4377 22-41 88-107anti-HIV_Chain 4378 22-41 93-112 anti-HIV_Chain 4379 22-41anti-HIV_Chain 4380 22-41 anti-HIV_Chain 4381 22-41 anti-HIV_Chain 438222-41 anti-HIV_Chain 4383 22-41 86-95 anti-HIV_Chain 4384 22-41 94-113anti-HIV_Chain 4385 22-41 anti-HIV_Chain 4386 22-41 anti-HIV_Chain 438722-41 49-58 anti-HIV_Chain 4388 22-41 anti-HIV_Chain 4389 22-41anti-HIV_Chain 4390 22-41 anti-HIV_Chain 4391 22-41 anti-HIV_Chain 439222-41 anti-HIV_Chain 4393 22-41 49-58 anti-HIV_Chain 4394 22-41anti-HIV_Chain 4395 22-41 anti-HIV_Chain 4396 22-41 93-112anti-HIV_Chain 4397 22-41 anti-HIV_Chain 4398 22-41 93-112anti-HIV_Chain 4399 22-41 94-113 anti-HIV_Chain 4400 22-41 93-112anti-HIV_Chain 4401 22-41 93-112 anti-HIV_Chain 4402 22-41 93-112anti-HIV_Chain 4403 22-41 93-112 anti-HIV_Chain 4404 22-41 93-112anti-HIV_Chain 4405 22-41 93-112 anti-HIV_Chain 4406 22-41 93-112anti-HIV_Chain 4407 22-41 59-68 94-113 anti-HIV_Chain 4408 22-41 93-112anti-HIV_Chain 4409 22-41 93-112 anti-HIV_Chain 4410 22-41anti-HIV_Chain 4411 22-41  93-102 anti-HIV_Chain 4412 22-41  93-102anti-HIV_Chain 4413 22-41 anti-HIV_Chain 4414 22-41 74-83 anti-HIV_Chain4415 22-41 93-112 anti-HIV_Chain 4416 22-41  93-102 anti-HIV_Chain 441722-41  93-102 anti-HIV_Chain 4418 22-41 74-83 anti-HIV_Chain 4419 22-4193-112 anti-HIV_Chain 4420 22-41 93-112 anti-HIV_Chain 4421 22-41 93-112anti-HIV_Chain 4422 22-41 93-112 anti-HIV_Chain 4423 22-41 93-112anti-HIV_Chain 4424 22-41 94-113 anti-HIV_Chain 4425 22-41  93-10294-113 anti-HIV_Chain 4426 22-41 94-113 anti-HIV_Chain 4427 22-41anti-HIV_Chain 4428 22-41 anti-HIV_Chain 4429 22-41 anti-HIV_Chain 443022-41 96-115 anti-HIV_Chain 4431 22-41 53-62 95-114 anti-HIV_Chain 443222-41 94-113 anti-HIV_Chain 4433 22-41 50-59 88-107 anti-HIV_Chain 443422-41 50-59 88-107 anti-HIV_Chain 4435 22-41 anti-HIV_Chain 4436 22-41anti-HIV_Chain 4437 22-41 anti-HIV_Chain 4438 22-41 anti-HIV_Chain 443922-41 anti-HIV_Chain 4440 22-41 anti-HIV_Chain 4441 22-41 anti-HIV_Chain4442 22-41 anti-HIV_Chain 4443 22-41 anti-HIV_Chain 4444 22-41anti-HIV_Chain 4445 22-41 59-68 94-113 anti-HIV_Chain 4446 22-41 94-113anti-HIV_Chain 4447 22-41  93-102 94-113 anti-HIV_Chain 4448 22-4197-116 anti-HIV_Chain 4449 22-41  92-101 anti-HIV_Chain 4450 22-41anti-HIV_Chain 4451 22-41 anti-HIV_Chain 4452 22-41 anti-HIV_Chain 445322-41 anti-HIV_Chain 4454 22-41 anti-HIV_Chain 4455 22-41 anti-HIV_Chain4456 22-41 anti-HIV_Chain 4457 22-41 anti-HIV_Chain 4458 22-41anti-HIV_Chain 4459 22-41 anti-HIV_Chain 4460 22-41 anti-HIV_Chain 446122-41 anti-HIV_Chain 4462 22-41 anti-HIV_Chain 4463 22-41 anti-HIV_Chain4464 22-41 103-122  anti-HIV_Chain 4465 22-41 93-112 anti-HIV_Chain 446622-41 58-67 94-113 anti-HIV_Chain 4467 22-41 108-117 anti-HIV_Chain 446822-41 50-59 88-107 anti-HIV_Chain 4469 22-41 93-112 anti-HIV_Chain 447022-41 96-115 anti-HIV_Chain 4471 22-41 55-64 anti-HIV_LightChain 447222-41 72-81 110-129  anti-HIV_Chain 4473 22-41 104-113 93-112anti-HIV_Chain 4474 22-41 104-113 anti-HIV_Chain 4475 22-41 104-11393-112 anti-HIV_Chain 4476 22-41 104-113 93-112 anti-HIV_Chain 447722-41 104-113 93-112 anti-HIV_Chain 4478 22-41 104-113 93-112anti-HIV_Chain 4479 22-41 104-113 anti-HIV_Chain 4480 22-41  92-101anti-HIV_Chain 4481 22-41 104-113 93-112 anti-HIV_Chain 4482 22-41104-113 93-112 anti-HIV_Chain 4483 22-41 anti-HIV_Chain 4484 22-41anti-HIV_Chain 4485 22-41 anti-HIV_Chain 4486 22-41 anti-HIV_Chain 448722-41 59-68 94-113 anti-HIV_Chain 4488 22-41 94-113 anti-HIV_Chain 448922-41 94-113 anti-HIV_Chain 4490 22-41  92-101 93-112 anti-HIV_Chain4491 22-41 94-113 anti-HIV_Chain 4492 22-41 59-68 94-113 anti-HIV_Chain4493 22-41 94-113 anti-HIV_Chain 4494 22-41 94-113 anti-HIV_Chain 449522-41 59-68 94-113 anti-HIV_Chain 4496 22-41 94-113 anti-HIV_Chain 449722-41 59-68 94-113 anti-HIV_Chain 4498 22-41 100-119  anti-HIV_Chain4499 22-41 100-119  anti-HIV_Chain 4500 22-41 anti-HIV_Chain 4501 22-41 93-102 94-113 anti-HIV_Chain 4502 22-41 100-119  anti-HIV_Chain 450322-41 94-113 anti-HIV_Chain 4504 22-41 94-113 anti-HIV_Chain 4505 22-41 93-102 94-113 anti-HIV_Chain 4506 22-41 97-116 anti-HIV_Chain 450722-41 97-116 anti-HIV_Chain 4508 22-41 94-113 anti-HIV_Chain 4509 22-4194-113 anti-HIV_Chain 4510 22-41 94-113 anti-HIV_Chain 4511 22-41 94-113anti-HIV_Chain 4512 22-41 94-113 anti-HIV_Chain 4513 22-41 97-116anti-HIV_Chain 4514 22-41 59-68 94-113 anti-HIV_Chain 4515 22-41 94-113anti-HIV_Chain 4516 22-41 97-116 anti-HIV_Chain 4517 22-41 93-112anti-HIV_Chain 4518 22-41 anti-HIV_Chain 4519 22-41 96-115anti-HIV_Chain 4520 22-41  93-102 94-113 anti-HIV_Chain 4521 22-41 56-6598-117 anti-HIV_Chain 4522 22-41 95-114 anti-HIV_Chain 4523 22-41 95-114anti-HIV_Chain 4524 22-41 94-113 anti-HIV_Chain 4525 22-41anti-HIV_Chain 4526 22-41 94-113 anti-HIV_Chain 4527 22-41  93-102anti-HIV_Chain 4528 22-41 anti-HIV_Chain 4529 22-41  93-102anti-HIV_Chain 4530 22-41  93-102 anti-HIV_Chain 4531 22-41anti-HIV_Chain 4532 22-41  93-102 anti-HIV_Chain 4533 22-41anti-HIV_Chain 4534 22-41 94-113 anti-HIV_Chain 4535 22-41anti-HIV_Chain 4536 22-41 anti-HIV_Chain 4537 22-41 anti-HIV_Chain 453822-41 anti-HIV_Chain 4539 22-41 anti-HIV_Chain 4540 22-41 anti-HIV_Chain4541 22-41 anti-HIV_Chain 4542 22-41 anti-HIV_LightChain 4543 22-4172-81 110-129  anti-HIV_Chain 4544 22-41 anti-HIV_Chain 4545 22-41anti-HIV_Chain 4546 22-41 57-66 99-118 anti-HIV_Chain 4547 22-41 96-115anti-HIV_Chain 4548 22-41 anti-HIV_Chain 4549 22-41  94-103 95-114anti-HIV_Chain 4550 22-41 97-116 anti-HIV_Chain 4551 22-41 94-113anti-HIV_Chain 4552 22-41 94-113 anti-HIV_Chain 4553 22-41anti-HIV_Chain 4554 22-41 anti-HIV_Chain 4555 22-41 anti-HIV_Chain 455622-41 anti-HIV_Chain 4557 22-41 94-113 anti-HIV_Chain 4558 22-41 94-113anti-HIV_Chain 4559 22-41 58-67 anti-HIV_Chain 4560 22-41 94-113anti-HIV_Chain 4561 22-41 94-113 anti-HIV_Chain 4562 22-41 60-69 95-114anti-HIV_HeavyChain 4563 22-41 anti-HIV_HeavyChain 4564 22-41anti-HIV_HeavyChain 4565 22-41 anti-HIV_Chain 4566 22-41 anti-HIV_Chain4567 22-41 96-115 anti-HIV_Chain 4568 22-41 101-120  anti-HIV_Chain 456922-41 96-115 anti-HIV_Chain 4570 22-41 61-70 96-115 anti-HIV_Chain 457122-41  93-102 94-113 anti-HIV_Chain 4572 22-41  93-102 94-113anti-HIV_Chain 4573 22-41 94-113 anti-HIV_Chain 4574 22-41 55-64anti-HIV_HeavyChain 4575 22-41 anti-HIV_HeavyChain 4576 22-41anti-HIV_HeavyChain 4577 22-41 anti-HIV_HeavyChain 4578 22-41anti-HIV_HeavyChain 4579 22-41 anti-HIV_HeavyChain 4580 22-41anti-HIV_HeavyChain 4581 22-41 anti-HIV_HeavyChain 4582 22-41anti-HIV_HeavyChain 4583 22-41 anti-HIV_HeavyChain 4584 22-41anti-HIV_HeavyChain 4585 22-41 anti-HIV_HeavyChain 4586 22-41anti-HIV_HeavyChain 4587 22-41 anti-HIV_Chain 4588 22-41 anti-HIV_Chain4589 22-41 anti-HIV_Chain 4590 22-41 94-113 anti-HIV_Chain 4591 22-4194-113 anti-HIV_Chain 4592 22-41 94-113 anti-HIV_Chain 4593 22-41 94-113anti-HIV_Chain 4594 22-41 94-113 anti-HIV_Chain 4595 22-41 94-113anti-HIV_Chain 4596 22-41 94-113 anti-HIV_Chain 4597 22-41 94-113anti-HIV_Chain 4598 22-41 94-113 anti-HIV_Chain 4599 22-41 100-119 anti-HIV_Chain 4600 22-41 94-113 anti-HIV_Chain 4601 22-41  93-10294-113 anti-HIV_Chain 4602 22-41 94-113 anti-HIV_Chain 4603 22-41 93-112anti-HIV_Chain 4604 22-41 81-100 anti-HIV_Chain 4605 22-41 94-113anti-HIV_Chain 4606 22-41 94-113 anti-HIV_HeavyChain 4607 22-41 70-79113-132  anti-HIV_HeavyChain 4608 22-41 70-79 113-132  anti-HIV_Chain4609 22-41 60-69 96-115 anti-HIV_Chain 4610 22-41 62-71 100-119 anti-HIV_Chain 4611 22-41 anti-HIV_Chain 4612 22-41 anti-HIV_Chain 461322-41 108-127  anti-HIV_Chain 4614 22-41 52-61 anti-HIV_HeavyChain 461522-41 70-79 113-132  anti-HIV_HeavyChain 4616 22-41 70-79 113-132 anti-HIV_Chain 4617 22-41 93-112 anti-HIV_Chain 4618 22-41 93-112anti-HIV_Chain 4619 22-41 93-112 anti-HIV_Chain 4620 22-41  93-102anti-HIV_Chain 4621 22-41 59-68 94-113 anti-HIV_Chain 4622 22-41 59-6894-113 anti-HIV_Chain 4623 22-41 anti-HIV_Chain 4624 22-41 59-68 94-113anti-HIV_LightChain 4625 22-41 48-57 86-105 anti-HIV_Chain 4626 22-4149-58 anti-HIV_Chain 4627 22-41 54-63 92-111 anti-HIV_SingleChain 462822-41 95-114 anti-HIV_LightChain 4629 22-41 anti-HIV_Chain 4630 22-41anti-HIV_Chain 4631 22-41 113-132  anti-influenza_Fab 4632 22-41 47-5685-104 anti-influenza_Fab 4633 22-41 93-112 anti-influenza_Fab 463422-41 226-235 anti-influenza_Fab 4635 22-41 94-113 anti-influenza_Fab4636 22-41 48-57 86-105 anti-influenza_Fab 4637 22-41 anti-influenza_Fab4638 22-41 anti-influenza_Apo 4639 22-41 85-104 anti-influenza_Apo 464022-41 94-113 anti-influenza-A_kappa_LightChain_V-Region 4641 22-41 52-6190-109 anti-influenza-A_kappa_LightChain_V-Region 4642 22-41 52-6190-109 anti-influenza-A_kappa_LightChain_V-Region 4643 22-41 52-6190-109 anti-influenza-A_kappa_LightChain_V-Region 4644 22-41 52-6190-109 anti-influenza-A_kappa_LightChain_V-Region 4645 22-41 54-6392-111 anti-influenza-A_kappa_LightChain_V-Region 4646 22-41 52-6190-109 anti-influenza-A_HeavyChain_V-Region 4647 22-41 94-113anti-influenza-A_HeavyChain_V-Region 4648 22-41 94-113anti-influenza-A_HeavyChain_V-Region 4649 22-41 94-113anti-influenza-A_HeavyChain_V-Region 4650 22-41 94-113anti-influenza-A_HeavyChain_V-Region 4651 22-41 94-113anti-influenza-A_HeavyChain_V-Region 4652 22-41 94-113anti-influenza-A_HeavyChain_V-Region 4653 22-41 94-113anti-influenza-A_LightChain_V-Region 4654 22-41 49-58 87-106anti-influenza-A_HeavyChain_V-Region 4655 22-41 94-113anti-influenza_Chain 4656 22-41 anti-influenza_Chain 4657 22-41anti-influenza_Chain 4658 22-41 51-60 anti-influenza_Chain 4659 22-41anti-influenza_Chain 4660 22-41 84-100 anti-influenza_Chain 4661 22-4145-54 83-100 anti-influenza_Chain 4662 22-41 47-56 85-102anti-influenza_Chain 4663 22-41 47-56 85-102 anti-influenza_Chain 466422-41 48-57 86-103 anti-influenza_Chain 4665 22-41 48-57 86-103anti-influenza_Chain 4666 22-41 48-57 86-103 anti-influenza_Chain 466722-41 48-57 86-103 anti-influenza_Chain 4668 22-41 48-57 86-103anti-influenza_Chain 4669 22-41 48-57 86-103 anti-influenza_Chain 467022-41 48-57 86-103 anti-influenza_Chain 4671 22-41 48-57 86-103anti-influenza_Chain 4672 22-41 48-57 86-103 anti-influenza_Chain 467322-41 86-105 anti-influenza_Chain 4674 22-41 86-105 anti-influenza_Chain4675 22-41 anti-influenza_Chain 4676 22-41 48-57 86-105anti-influenza_Chain 4677 22-41 48-57 anti-influenza_Chain 4678 22-4186-105 anti-influenza_Chain 4679 22-41 86-105 anti-influenza_Chain 468022-41 48-57 anti-influenza_Chain 4681 22-41 86-105 anti-influenza_Chain4682 22-41 48-57 anti-influenza_Chain 4683 22-41 29-38 86-105anti-influenza_Chain 4684 22-41 29-38 86-105 anti-influenza_Chain 468522-41 86-105 anti-influenza_Chain 4686 22-41 86-105 anti-influenza_Chain4687 22-41 86-105 anti-influenza_Chain 4688 22-41 48-57 86-105anti-influenza_Chain 4689 22-41 29-38 anti-influenza_Chain 4690 22-4148-57 86-105 anti-influenza_Chain 4691 22-41 86-105 anti-influenza_Chain4692 22-41 86-105 anti-influenza_Chain 4693 22-41 86-105anti-influenza_Chain 4694 22-41 48-57 86-105 anti-influenza_Chain 469522-41 31-40 86-105 anti-influenza_Chain 4695 22-41 48-57anti-influenza_Chain 4697 22-41 86-105 anti-influenza_Chain 4698 22-4148-57 86-105 anti-influenza_Chain 4699 22-41 29-38 86-105anti-influenza_Chain 4700 22-41 anti-influenza_Chain 4701 22-41 86-105anti-influenza_Chain 4702 22-41 86-105 anti-influenza_Chain 4703 22-4148-57 86-105 anti-influenza_Chain 4704 22-41 86-105 anti-influenza_Chain4705 22-41 86-105 anti-influenza_Chain 4706 22-41 48-57 86-105anti-influenza_Chain 4707 22-41 48-57 anti-influenza_Chain 4708 22-4186-105 anti-influenza_Chain 4709 22-41 29-38 86-105 anti-influenza_Chain4710 22-41 47-56 85-104 anti-influenza_Chain 4711 22-41 48-57 86-105anti-influenza_Chain 4712 22-41  97-106 87-106 anti-influenza_Chain 471322-41  97-106 87-106 anti-influenza_Chain 4714 22-41 85-94 86-105anti-influenza_Chain 4715 22-41 29-38 86-105 anti-influenza_Chain 471622-41 48-57 anti-influenza_Chain 4717 22-41 48-57 anti-influenza_Chain4718 22-41 48-57 anti-influenza_Chain 4719 22-41 48-57 86-105anti-influenza_Chain 4720 22-41 48-57 86-105 anti-influenza_Chain 472122-41 48-57 86-105 anti-influenza_Chain 4722 22-41 48-57 86-105anti-influenza_Chain 4723 22-41 48-57 86-105 anti-influenza_Chain 472422-41 49-58 87-106 anti-influenza_Chain 4725 22-41 49-58 87-106anti-influenza_Chain 4726 22-41 49-58 87-106 anti-influenza_Chain 472722-41 48-57 86-105 anti-influenza_Chain 4728 22-41 49-58 87-106anti-influenza_Chain 4729 22-41 49-58 anti-influenza_Chain 4730 22-4187-106 anti-influenza_Chain 4731 22-41 48-57 86-105 anti-influenza_Chain4732 22-41 47-56 85-104 anti-influenza_Chain 4733 22-41 85-104anti-influenza_Chain 4734 22-41 49-58 87-106 anti-influenza_Chain 473522-41 48-57 86-105 anti-influenza_Chain 4736 22-41 90-108anti-influenza_Chain 4737 22-41 48-57 86-105 anti-influenza_Chain 473822-41 87-106 anti-influenza_Chain 4739 22-41 48-57 85-105anti-influenza_Chain 4740 22-41 47-56 anti-influenza_Chain 4741 22-4147-56 anti-influenza_Chain 4742 22-41  98-107 88-107anti-influenza_Chain 4743 22-41 89-108 anti-influenza_Chain 4744 22-41anti-influenza_Chain 4745 22-41 86-105 anti-influenza_Chain 4746 22-4149-58 87-106 anti-influenza_Chain 4747 22-41 48-57 86-105anti-influenza_Chain 4748 22-41 49-58 87-106 anti-influenza_Chain 474922-41 49-58 anti-influenza_Chain 4750 22-41 49-58 anti-influenza_Chain4751 22-41 48-57 86-105 anti-influenza_Chain 4752 22-41 88-107anti-influenza_Chain 4753 22-41 48-57 86-105 anti-influenza_Chain 475422-41 48-57 86-105 anti-influenza_Chain 4755 22-41 48-57 86-105anti-influenza_Chain 4756 22-41 48-57 86-105 anti-influenza_Chain 475722-41 48-57 86-105 anti-influenza_Chain 4758 22-41 49-58 87-106anti-influenza_Chain 4759 22-41 85-104 anti-influenza_Chain 4760 22-4149-58 87-106 anti-influenza_Chain 4761 22-41 85-104 anti-influenza_Chain4762 22-41 49-58 87-106 anti-influenza_Chain 4763 22-41 85-104anti-influenza_Chain 4764 22-41 85-104 anti-influenza_Chain 4765 22-4187-106 anti-influenza_Chain 4766 22-41 85-104 anti-influenza_Chain 476722-41 85-104 anti-influenza_Chain 4768 22-41 49-58 87-106anti-influenza_Chain 4769 22-41 86-105 anti-influenza_Chain 4770 22-4186-105 anti-influenza_Chain 4771 22-41 86-105 anti-influenza_Chain 477222-41 86-105 anti-influenza_Chain 4773 22-41 86-105 anti-influenza_Chain4774 22-41 86-105 anti-influenza_Chain 4775 22-41 86-105anti-influenza_Chain 4776 22-41 86-105 anti-influenza_Chain 4777 22-4186-105 anti-influenza_Chain 4778 22-41 48-57 86-105 anti-influenza_Chain4779 22-41 48-57 86-105 anti-influenza_Chain 4780 22-41 48-57 86-105anti-influenza_Chain 4781 22-41 48-57 86-105 anti-influenza_Chain 478222-41 48-57 86-105 anti-influenza_Chain 4783 22-41 48-57 86-105anti-influenza_Chain 4784 22-41 48-57 86-105 anti-influenza_Chain 478522-41 48-57 86-105 anti-influenza_Chain 4786 22-41 48-57 86-105anti-influenza_Chain 4787 22-41 48-57 86-105 anti-influenza_Chain 478822-41 48-57 86-105 anti-influenza_Chain 4789 22-41 48-57anti-influenza_Chain 4790 22-41 29-38 86-105 anti-influenza_Chain 479122-41 48-57 86-105 anti-influenza_Chain 4792 22-41 48-57 86-105anti-influenza_Chain 4793 22-41 86-105 anti-influenza_Chain 4794 22-4187-106 anti-influenza_Chain 4795 22-41 49-58 87-106 anti-influenza_Chain4796 22-41 48-57 86-105 anti-influenza_Chain 4797 22-41 49-58 87-106anti-influenza_Chain 4798 22-41 50-59 anti-influenza_Chain 4799 22-4150-59 88-107 anti-influenza_Chain 4800 22-41 50-59 88-107anti-influenza_Chain 4801 22-41 49-58 87-106 anti-influenza_Chain 480222-41 anti-influenza_Chain 4803 22-41 50-59 89-108 anti-influenza_Chain4804 22-41 48-57 86-105 anti-influenza_Chain 4805 22-41 49-58 87-106anti-influenza_Chain 4806 22-41 88-107 anti-influenza_Chain 4807 22-4149-58 87-106 anti-influenza_Chain 4808 22-41 48-57 86-105anti-influenza_Chain 4809 22-41 85-104 anti-influenza_Chain 4810 22-4187-106 anti-influenza_Chain 4811 22-41 48-57 86-105 anti-influenza_Chain4812 22-41 48-57 86-105 anti-influenza_Chain 4813 22-41 48-57anti-influenza_Chain 4814 22-41 85-104 anti-influenza_Chain 4815 22-4186-105 anti-influenza_Chain 4816 22-41 50-59 88-107 anti-influenza_Chain4817 22-41 50-59 88-107 anti-influenza_Chain 4818 22-41 50-59 88-107anti-influenza_Chain 4819 22-41 88-107 anti-influenza_Chain 4820 22-4150-59 88-107 anti-influenza_Chain 4821 22-41 50-59 88-107anti-influenza_Chain 4822 22-41 50-59 88-107 anti-influenza_Chain 482322-41 88-107 anti-influenza_Chain 4824 22-41 88-107 anti-influenza_Chain4825 22-41 88-107 anti-influenza_Chain 4826 22-41 52-61 90-109anti-influenza_Chain 4827 22-41 50-59 88-107 anti-influenza_Chain 482822-41 49-58 87-106 anti-influenza_Chain 4829 22-41 49-58 87-106anti-influenza_Chain 4830 22-41 50-59 88-107 anti-influenza_Chain 483122-41 49-58 89-108 anti-influenza_Chain 4832 22-41 49-58 87-106anti-influenza_Chain 4833 22-41 48-57 86-105 anti-influenza_Chain 483422-41 49-58 87-106 anti-influenza_Chain 4835 22-41 50-59 88-107anti-influenza_Chain 4836 22-41 87-106 anti-influenza_Chain 4837 22-4148-57 86-105 anti-influenza_Chain 4838 22-41 50-59 88-107anti-influenza_Chain 4839 22-41 49-58 87-106 anti-influenza_Chain 484022-41 50-59 88-107 anti-influenza_Chain 4841 22-41 49-58 87-106anti-influenza_Chain 4842 22-41 50-59 88-107 anti-influenza_Chain 484322-41 anti-influenza_Chain 4844 22-41 87-106 anti-influenza_Chain 484522-41 anti-influenza_Chain 4846 22-41 anti-influenza_Chain 4847 22-41anti-influenza_Chain 4848 22-41 31-40 90-109 anti-influenza_Chain 484922-41 31-40 90-109 anti-influenza_Chain 4850 22-41 48-57 86-105anti-influenza_Chain 4851 22-41 92-111 anti-influenza_Chain 4852 22-4153-62 91-110 anti-influenza_Chain 4853 22-41 91-110 anti-influenza_Chain4854 22-41 91-110 anti-influenza_Chain 4855 22-41 53-62 91-110anti-influenza_Chain 4856 22-41 50-59 88-107 anti-influenza_Chain 485722-41 88-107 anti-influenza_Chain 4858 22-41 49-58 87-106anti-influenza_Chain 4859 22-41 49-58 87-106 anti-influenza_Chain 486022-41 53-62 91-110 anti-influenza_Chain 4861 22-41 87-106anti-influenza_Chain 4862 22-41 50-59 88-107 anti-influenza_Chain 486322-41 anti-influenza_Chain 4864 22-41 anti-influenza_Chain 4865 22-41anti-influenza_Chain 4866 22-41 anti-influenza_Chain 4867 22-41 53-6291-110 anti-influenza_Chain 4868 22-41 54-63 92-111 anti-influenza_Chain4869 22-41 54-63 92-111 anti-influenza_Chain 4870 22-41 54-63 92-111anti-influenza_Chain 4871 22-41 54-63 anti-influenza_Chain 4872 22-4153-62 91-110 anti-influenza_Chain 4873 22-41 88-107 anti-influenza_Chain4874 22-41 54-63 92-111 anti-influenza_Chain 4875 22-41 54-63 92-111anti-influenza_Chain 4876 22-41 48-57 86-105 anti-influenza_Chain 487722-41 48-57 anti-influenza_Chain 4878 22-41 53-62 91-110anti-influenza_Chain 4879 22-41 53-62 91-110 anti-influenza_Chain 488022-41 94-113 anti-influenza_Chain 4881 22-41 94-113 anti-influenza_Chain4882 22-41 94-113 anti-influenza_Chain 4883 22-41 94-113anti-influenza_Chain 4884 22-41 36-45 91-110 anti-influenza_Chain 488522-41 50-59 88-107 anti-influenza_Chain 4886 22-41 54-63 92-111anti-influenza_Chain 4887 22-41 53-62 91-110 anti-influenza_Chain 488822-41 89-98 90-109 anti-influenza_Chain 4889 22-41 94-113anti-influenza_Chain 4890 22-41 51-60 anti-influenza_Chain 4891 22-4131-40 94-113 anti-influenza_Chain 4892 22-41 52-61 94-113anti-influenza_Chain 4893 22-41 anti-influenza_Chain 4894 22-41 94-113anti-influenza_Chain 4895 22-41 94-113 anti-influenza_Chain 4896 22-4194-113 anti-influenza_Chain 4897 22-41 91-110 anti-influenza_Chain 489822-41 anti-influenza_Chain 4899 22-41 94-113 anti-influenza_Chain 490022-41 93-112 anti-influenza_Chain 4901 22-41 93-112 anti-influenza_Chain4902 22-41 93-112 anti-influenza_Chain 4903 22-41 95-114anti-influenza_Chain 4904 22-41 94-113 anti-influenza_Chain 4905 22-4194-113 anti-influenza_Chain 4906 22-41 51-60 anti-influenza_Chain 490722-41 51-60 93-112 anti-influenza_Chain 4908 22-41 51-60 93-112anti-influenza_Chain 4909 22-41 51-60 93-112 anti-influenza_Chain 491022-41 93-112 anti-influenza_Chain 4911 22-41 94-113 anti-influenza_Chain4912 22-41 94-113 anti-influenza_Chain 4913 22-41 93-112anti-influenza_Chain 4914 22-41 anti-influenza_Chain 4915 22-41 53-6295-114 anti-influenza_Chain 4916 22-41  93-102 anti-influenza_Chain 491722-41 94-113 anti-influenza_Chain 4918 22-41 93-112 anti-influenza_Chain4919 22-41 51-60 93-112 anti-influenza_Chain 4920 22-41 93-112anti-influenza_Chain 4921 22-41  92-101 93-112 anti-influenza_Chain 492222-41 51-60 93-112 anti-influenza_Chain 4923 22-41 51-60anti-influenza_Chain 4924 22-41 anti-influenza_Chain 4925 22-41 94-113anti-influenza_Chain 4926 22-41 94-113 anti-influenza_Chain 4927 22-4194-113 anti-influenza_Chain 4928 22-41 94-113 anti-influenza_Chain 492922-41 94-113 anti-influenza_Chain 4930 22-41 94-113 anti-influenza_Chain4931 22-41 94-113 anti-influenza_Chain 4932 22-41 94-113anti-influenza_Chain 4933 22-41 94-113 anti-influenza_Chain 4934 22-4159-68 94-113 anti-influenza_Chain 4935 22-41 94-113 anti-influenza_Chain4936 22-41 94-113 anti-influenza_Chain 4937 22-41 95-114anti-influenza_Chain 4938 22-41 94-113 anti-influenza_Chain 4939 22-4194-113 anti-influenza_Chain 4940 22-41 anti-influenza_Chain 4941 22-4134-43 94-113 anti-influenza_Chain 4942 22-41 51-60 anti-influenza_Chain4943 22-41 92-111 anti-influenza_Chain 4944 22-41 100-109 94-113anti-influenza_Chain 4945 22-41 93-112 anti-influenza_Chain 4946 22-4193-112 anti-influenza_Chain 4947 22-41 anti-influenza_Chain 4948 22-4194-113 anti-influenza_Chain 4949 22-41 94-113 anti-influenza_Chain 495022-41 94-113 anti-influenza_Chain 4951 22-41 103-112 94-113anti-influenza_Chain 4952 22-41 anti-influenza_Chain 4953 22-41 94-113anti-influenza_Chain 4954 22-41 94-113 anti-influenza_Chain 4955 22-41 93-102 94-113 anti-influenza_Chain 4956 22-41 94-113anti-influenza_Chain 4957 22-41 94-113 anti-influenza_Chain 4958 22-4158-67 94-113 anti-influenza_Chain 4959 22-41 58-67 94-113anti-influenza_Chain 4960 22-41 51-60 94-113 anti-influenza_Chain 496122-41 94-113 anti-influenza_Chain 4962 22-41 94-113 anti-influenza_Chain4963 22-41 anti-influenza_Chain 4964 22-41 94-113 anti-influenza_Chain4965 22-41 anti-influenza_Chain 4966 22-41 51-60 93-112anti-influenza_Chain 4967 22-41 94-113 anti-influenza_Chain 4968 22-41anti-influenza_Chain 4969 22-41  93-102 94-113 anti-influenza_Chain 497022-41 94-113 anti-influenza_Chain 4971 22-41 anti-influenza_Chain 497222-41 58-67 94-113 anti-influenza_Chain 4973 22-41 94-113anti-influenza_Chain 4974 22-41 94-113 anti-influenza_Chain 4975 22-4194-113 anti-influenza_Chain 4976 22-41 94-113 anti-influenza_Chain 497722-41 94-113 anti-influenza_Chain 4978 22-41 93-112 anti-influenza_Chain4979 22-41 93-112 anti-influenza_Chain 4980 22-41 94-113anti-influenza_Chain 4981 22-41 anti-influenza_Chain 4982 22-41 94-113anti-influenza_Chain 4983 22-41 53-62 95-114 anti-influenza_Chain 498422-41 94-113 anti-influenza_Chain 4985 22-41 53-62 95-114anti-influenza_Chain 4986 22-41 94-113 anti-influenza_Chain 4987 22-41anti-influenza_Chain 4988 22-41 51-60 94-113 anti-influenza_Chain 498922-41 95-114 anti-influenza_Chain 4990 22-41  93-102 94-113anti-influenza_Chain 4991 22-41  93-102 94-113 anti-influenza_Chain 499222-41 59-68 94-113 anti-influenza_Chain 4993 22-41 59-68 94-113anti-influenza_Chain 4994 22-41 59-68 94-113 anti-influenza_Chain 499522-41 59-68 94-113 anti-influenza_Chain 4996 22-41 59-68 94-113anti-influenza_Chain 4997 22-41 59-68 94-113 anti-influenza_Chain 499822-41 59-68 94-113 anti-influenza_Chain 4999 22-41 59-68 94-113anti-influenza_Chain 5000 22-41 59-68 94-113 anti-influenza_Chain 500122-41 94-113 anti-influenza_Chain 5002 22-41 93-112 anti-influenza_Chain5003 22-41 53-62 95-114 anti-influenza_Chain 5004 22-41 53-62 95-114anti-influenza_Chain 5005 22-41 94-113 anti-influenza_Chain 5006 22-41 93-102 anti-influenza_Chain 5007 22-41 51-60 94-113anti-influenza_Chain 5008 22-41 51-60 anti-influenza_Chain 5009 22-4194-113 anti-influenza_Chain 5010 22-41 53-62 95-114 anti-influenza_Chain5011 22-41 51-60 anti-influenza_Chain 5012 22-41 94-113anti-influenza_Chain 5013 22-41  93-102 94-113 anti-influenza_Chain 501422-41 51-60 94-113 anti-influenza_Chain 5015 22-41 94-113anti-influenza_Chain 5016 22-41 53-62 95-114 anti-influenza_Chain 501722-41 94-113 anti-influenza_Chain 5018 22-41 51-60 94-113anti-influenza_Chain 5019 22-41 51-60 94-113 anti-influenza_Chain 502022-41 94-113 anti-influenza_Chain 5021 22-41 94-113 anti-influenza_Chain5022 22-41 94-113 anti-influenza_Chain 5023 22-41 94-113anti-influenza_Chain 5024 22-41 anti-influenza_Chain 5025 22-41 94-113anti-influenza_Chain 5026 22-41 anti-influenza_Chain 5027 22-41 94-113anti-influenza_Chain 5028 22-41 98-117 anti-influenza_Chain 5029 22-4151-60 93-112 anti-influenza_Chain 5030 22-41 94-113 anti-influenza_Chain5031 22-41 anti-influenza_Chain 5032 22-41 92-111 anti-influenza_Chain5033 22-41 94-113 anti-influenza_Chain 5034 22-41 94-113anti-influenza_Chain 5035 22-41 94-113 anti-influenza_Chain 5036 22-4194-113 anti-influenza_Chain 5037 22-41 53-62 95-114 anti-influenza_Chain5038 22-41 54-63 94-113 anti-influenza_Chain 5039 22-41 31-40 94-113anti-influenza_Chain 5040 22-41  96-105 97-116 anti-influenza_Chain 504122-41 93-112 anti-influenza_Chain 5042 22-41 51-60 94-113anti-influenza_Chain 5043 22-41 anti-influenza_Chain 5044 22-41anti-influenza_Chain 5045 22-41  96-105 97-116 anti-influenza_Chain 504622-41  96-105 97-116 anti-influenza_Chain 5047 22-41  96-105 97-116anti-influenza_Chain 5048 22-41 anti-influenza_Chain 5049 22-41 97-116anti-influenza_Chain 5050 22-41 97-116 anti-influenza_Chain 5051 22-4197-116 anti-influenza_Chain 5052 22-41 97-116 anti-influenza_Chain 505322-41 94-113 anti-influenza_Chain 5054 22-41 93-112 anti-influenza_Chain5055 22-41  92-101 93-112 anti-influenza_Chain 5056 22-41 93-112anti-influenza_Chain 5057 22-41 95-114 anti-influenza_Chain 5058 22-4194-113 anti-influenza_Chain 5059 22-41 94-113 anti-influenza_Chain 506022-41 94-113 anti-influenza_Chain 5061 22-41 98-117 anti-influenza_Chain5062 22-41 anti-influenza_Chain 5063 22-41 anti-influenza_Chain 506422-41 anti-influenza_Chain 5065 22-41 114-123 94-113anti-influenza_Chain 5066 22-41 94-113 anti-influenza_Chain 5067 22-4194-113 anti-influenza_Chain 5068 22-41 94-113 anti-influenza_Chain 506922-41 51-60 93-112 anti-influenza_Chain 5070 22-41 94-113anti-influenza_Chain 5071 22-41 anti-influenza_Chain 5072 22-41 96-115anti-influenza_Chain 5073 22-41 51-60 94-113 anti-influenza_Chain 507422-41 94-113 anti-influenza_Chain 5075 22-41 anti-influenza_Chain 507622-41 94-113 anti-influenza_Chain 5077 22-41 53-62 95-114anti-influenza_Chain 5078 22-41 94-113 anti-influenza_Chain 5079 22-4195-114 anti-influenza_Chain 5080 22-41 anti-influenza_Chain 5081 22-4194-113 anti-influenza_Chain 5082 22-41 94-113 anti-influenza_Chain 508322-41 94-113 anti-influenza_Chain 5084 22-41 95-114 anti-influenza_Chain5085 22-41 95-114 anti-influenza_Chain 5086 22-41 anti-influenza_Chain5087 22-41  93-102 94-113 anti-influenza_Chain 5088 22-41 96-115anti-influenza_Chain 5089 22-41 96-115 anti-influenza_Chain 5090 22-4196-115 anti-influenza_Chain 5091 22-41 96-115 anti-influenza_Chain 509222-41 96-115 anti-influenza_Chain 5093 22-41 96-115 anti-influenza_Chain5094 22-41 96-115 anti-influenza_Chain 5095 22-41 96-115anti-influenza_Chain 5096 22-41 96-115 anti-influenza_Chain 5097 22-4196-115 anti-influenza_Chain 5098 22-41 96-115 anti-influenza_Chain 509922-41 96-115 anti-influenza_Chain 5100 22-41 99-118 anti-influenza_Chain5101 22-41 anti-influenza_Chain 5102 22-41 anti-influenza_Chain 510322-41 122-131 anti-influenza_Chain 5104 22-41 183-192anti-influenza_Chain 5105 22-41 48-57 86-105 anti-influenza_Chain 510622-41 86-105 anti-influenza_Chain 5107 22-41 48-57 86-105anti-influenza_Chain 5108 22-41 49-58 87-106 anti-influenza_Chain 510922-41 47-56 85-104 anti-influenza_Chain 5110 22-41 48-57anti-influenza_Chain 5111 22-41 anti-influenza_Chain 5112 22-41 48-5786-105 anti-influenza_Chain 5113 22-41  97-106 87-106anti-influenza_Chain 5114 22-41  97-106 87-106 anti-influenza_Chain 511522-41 47-56 85-104 anti-influenza_Chain 5116 22-41 50-59 88-107anti-influenza_Chain 5117 22-41 86-105 anti-influenza_Chain 5118 22-4186-105 anti-influenza_Chain 5119 22-41 86-105 anti-influenza_Chain 512022-41 86-105 anti-influenza_Chain 5121 22-41 86-105 anti-influenza_Chain5122 22-41 86-105 anti-influenza_Chain 5123 22-41 86-105anti-influenza_Chain 5124 22-41 86-105 anti-influenza_Chain 5125 22-4186-105 anti-influenza_Chain 5126 22-41 48-57 86-105 anti-influenza_Chain5127 22-41 48-57 86-105 anti-influenza_Chain 5128 22-41 48-57 86-105anti-influenza_Chain 5129 22-41 48-57 86-105 anti-influenza_Chain 513022-41 48-57 86-105 anti-influenza_Chain 5131 22-41 48-57 86-105anti-influenza_Chain 5132 22-41 48-57 86-105 anti-influenza_Chain 513322-41 48-57 86-105 anti-influenza_Chain 5134 22-41 53-62 91-110anti-influenza_Chain 5135 22-41 87-106 anti-influenza_Chain 5136 22-41 98-107 88-107 anti-influenza_Chain 5137 22-41 49-58 87-106anti-influenza_Chain 5138 22-41 49-58 87-106 anti-influenza_Chain 513922-41 49-58 87-106 anti-influenza_Chain 5140 22-41 85-104anti-influenza_Chain 5141 22-41 85-104 anti-influenza_Chain 5142 22-41anti-influenza_Chain 5143 22-41 49-58 87-106 anti-influenza_Chain 514422-41 53-62 91-110 anti-influenza_Chain 5145 22-41 49-58 87-106anti-influenza_Chain 5146 22-41 50-59 88-107 anti-influenza_Chain 514722-41 87-106 anti-influenza_Chain 5148 22-41 49-58 87-106anti-influenza_Chain 5149 22-41 50-59 88-107 anti-influenza_Chain 515022-41 49-58 87-106 anti-influenza_Chain 5151 22-41 49-58 87-106anti-influenza_Chain 5152 22-41 145-154 anti-influenza_Chain 5153 22-41anti-influenza_Chain 5154 22-41 anti-influenza_Chain 5155 22-41 106-125 anti-influenza_Chain 5156 22-41 68-77 anti-influenza_Chain 5157 22-41105-114 anti-influenza_Chain 5158 22-41 69-78 107-126 anti-influenza_Chain 5159 22-41 69-78 107-126  anti-influenza_Chain 516022-41 68-77 anti-influenza_Chain 5161 22-41 anti-influenza_Chain 516222-41 183-192 94-113 anti-influenza_Chain 5163 22-41 184-193 94-113anti-influenza_Chain 5164 22-41 anti-influenza_Chain 5165 22-41 184-193222-241  anti-influenza_Chain 5166 22-41 185-194 94-113anti-influenza_Chain 5167 22-41 94-113 anti-influenza_Chain 5168 22-41185-194 94-113 anti-influenza_Chain 5169 22-41 94-113anti-influenza_Chain 5170 22-41 94-113 anti-influenza_Chain 5171 22-4194-113 anti-influenza_Chain 5172 22-41 58-67 94-113 anti-influenza_Chain5173 22-41 94-113 anti-influenza_Chain 5174 22-41 186-195 94-113anti-influenza_Chain 5175 22-41 31-40 94-113 anti-influenza_Chain 517622-41 222-241  anti-influenza_Chain 5177 22-41 186-195 94-113anti-influenza_Chain 5178 22-41 94-113 anti-influenza_Chain 5179 22-41186-195 94-113 anti-influenza_Chain 5180 22-41 186-195 94-113anti-influenza_Chain 5181 22-41 187-196 94-113 anti-influenza_Chain 518222-41 94-113 anti-influenza_Chain 5183 22-41 186-195 94-113anti-influenza_Chain 5184 22-41 103-112 94-113 anti-influenza_Chain 518522-41 anti-influenza_Chain 5186 22-41 186-195 94-113anti-influenza_Chain 5187 22-41 188-197 94-113 anti-influenza_Chain 518822-41 94-113 anti-influenza_Chain 5189 22-41 196-205 92-111anti-influenza_Chain 5190 22-41 196-205 92-111 anti-influenza_Chain 519122-41 anti-influenza_Chain 5192 22-41 anti-influenza_Chain 5193 22-41anti-influenza_Chain 5194 22-41 anti-influenza_Chain 5195 22-41 48-57223-242  anti-influenza_Chain 5196 22-41 48-57 223-242 anti-influenza_Chain 5197 22-41 anti-influenza_Chain 5198 22-41anti-influenza_Chain 5199 22-41 118-127 anti-influenza_Chain 5200 22-41118-127 anti-influenza_Chain 5201 22-41 anti-influenza_Chain 5202 22-41anti-influenza_Chain 5203 22-41 anti-influenza_Chain 5204 22-41anti-influenza_Chain 5205 22-41 anti-influenza_Chain 5206 22-41anti-influenza_Chain 5207 22-41 298-307 anti-influenza_Chain 5208 22-41298-307 anti-influenza_Chain 5209 22-41 anti-influenza_Chain 5210 22-41anti-influenza_Chain 5211 22-41 anti-influenza_Chain 5212 22-41anti-influenza_Chain 5213 22-41 anti-influenza_Chain 5214 22-41anti-influenza_Chain 5215 22-41 189-198 anti-influenza_Chain 5216 22-41189-198 anti-influenza_Chain 5217 22-41 anti-influenza_Chain 5218 22-41anti-influenza_Chain 5219 22-41 anti-influenza_Chain 5220 22-41anti-influenza_Chain 5221 22-41 240-249 anti-influenza_Chain 5222 22-4151-60 94-113 anti-influenza_Chain 5223 22-41 51-60 94-113anti-influenza_Chain 5224 22-41 240-249 anti-influenza_Chain 5225 22-41267-276 anti-influenza_Chain 5226 22-41 267-276 anti-influenza_Chain5227 22-41 anti-influenza_Chain 5228 22-41 anti-influenza_Chain 522922-41 anti-influenza_Chain 5230 22-41 anti-influenza_Chain 5231 22-41anti-influenza_Chain 5232 22-41 anti-influenza_Chain 5233 22-41anti-influenza_Chain 5234 22-41 anti-influenza_Chain 5235 22-41anti-influenza_Chain 5236 22-41 anti-influenza_Chain 5237 22-41 204-213anti-influenza_Chain 5238 22-41 204-213 anti-influenza_Chain 5239 22-4196-115 anti-influenza_Chain 5240 22-41 96-115 anti-influenza_Chain 524122-41 94-113 anti-influenza_Chain 5242 22-41 94-113 anti-influenza_Chain5243 22-41 anti-influenza_Chain 5244 22-41 anti-influenza_Chain 524522-41 95-114 anti-influenza_Chain 5246 22-41 95-114 anti-influenza_Chain5247 22-41 94-113 anti-influenza_Chain 5248 22-41 anti-influenza_Chain5249 22-41 94-113 anti-influenza_Chain 5250 22-41 94-113anti-influenza_Chain 5251 22-41 94-113 anti-influenza_Chain 5252 22-4194-113 anti-influenza_Chain 5253 22-41 94-113 anti-influenza_Chain 525422-41 94-113 anti-influenza_Chain 5255 22-41 94-113 anti-influenza_Chain5256 22-41 94-113 anti-influenza_Chain 5257 22-41 94-113anti-influenza_Chain 5258 22-41 anti-influenza_Chain 5259 22-41 94-113anti-influenza_Chain 5260 22-41 94-113 anti-influenza_Chain 5261 22-4194-113 anti-influenza_Chain 5262 22-41 94-113 anti-influenza_Chain 526322-41 94-113 anti-influenza_Chain 5264 22-41 103-112 94-113anti-influenza_Chain 5265 22-41 94-113 anti-influenza_Chain 5266 22-4194-113 anti-influenza_Chain 5267 22-41 103-112 94-113anti-influenza_Chain 5268 22-41 58-67 94-113 anti-influenza_Chain 526922-41 94-113 anti-influenza_Chain 5270 22-41  93-102 94-113anti-influenza_Chain 5271 22-41 94-113 anti-influenza_Chain 5272 22-4158-67 94-113 anti-influenza_Chain 5273 22-41  93-102 94-113anti-influenza_Chain 5274 22-41 94-113 anti-influenza_Chain 5275 22-41 93-102 94-113 anti-influenza_Chain 5276 22-41  93-102 94-113anti-influenza_Chain 5277 22-41 59-68 94-113 anti-influenza_Chain 527822-41 59-68 94-113 anti-influenza_Chain 5279 22-41 59-68 94-113anti-influenza_Chain 5280 22-41 59-68 94-113 anti-influenza_Chain 528122-41 59-68 94-113 anti-influenza_Chain 5282 22-41 59-68 94-113anti-influenza_Chain 5283 22-41 59-68 94-113 anti-influenza_Chain 528422-41 59-68 94-113 anti-influenza_Chain 5285 22-41 59-68 94-113anti-influenza_Chain 5286 22-41 94-113 anti-influenza_Chain 5287 22-41 93-102 94-113 anti-influenza_Chain 5288 22-41  93-102 94-113anti-influenza_Chain 5289 22-41 59-68 94-113 anti-influenza_Chain 529022-41 59-68 94-113 anti-influenza_Chain 5291 22-41 59-68 94-113anti-influenza_Chain 5292 22-41 59-68 94-113 anti-influenza_Chain 529322-41 59-68 94-113 anti-influenza_Chain 5294 22-41 59-68 94-113anti-influenza_Chain 5295 22-41 59-68 94-113 anti-influenza_Chain 529622-41 59-68 94-113 anti-influenza_Chain 5297 22-41 59-68 94-113anti-influenza_Chain 5298 22-41 51-60 94-113 anti-influenza_Chain 529922-41 51-60 94-113 anti-influenza_Chain 5300 22-41 94-113anti-influenza_Chain 5301 22-41 94-113 anti-influenza_Chain 5302 22-4194-113 anti-influenza_Chain 5303 22-41 94-113 anti-influenza_Chain 530422-41 anti-influenza_Chain 5305 22-41 51-60 94-113 anti-influenza_Chain5306 22-41 51-60 94-113 anti-influenza_Chain 5307 22-41 94-113anti-influenza_Chain 5308 22-41 94-113 anti-influenza_Chain 5309 22-4194-113 anti-influenza_Chain 5310 22-41 94-113 anti-influenza_Chain 531122-41 anti-influenza_Chain 5312 22-41 94-113 anti-influenza_Chain 531322-41 anti-influenza_Chain 5314 22-41 anti-influenza_Chain 5315 22-41115-134  anti-influenza_Chain 5316 22-41 115-134  anti-influenza_Chain5317 22-41 113-132  anti-influenza_Chain 5318 22-41 anti-influenza_Chain5319 22-41 anti-influenza_Chain 5320 22-41 113-132  anti-influenza_Chain5321 22-41 445-454 anti-influenza_Chain 5322 22-41 445-454anti-influenza_Chain 5323 22-41 anti-influenza_Chain 5324 22-41anti-influenza_Chain 5325 22-41 anti-influenza_Chain 5326 22-41anti-influenza_Chain 5327 22-41 anti-influenza_Chain 5328 22-41 113-132 anti-influenza_Chain 5329 22-41 113-132  anti-influenza_Chain 5330 22-41113-132  anti-influenza_Chain 5331 22-41 anti-influenza_Chain 5332 22-41anti-influenza_Chain 5333 22-41 anti-influenza_Chain 5334 22-41anti-influenza_Chain 5335 22-41 113-132  anti-influenza_Chain 5336 22-41113-132  anti-influenza_Chain 5337 22-41 113-132  anti-influenza_Chain5338 22-41 anti-influenza_Chain 5339 22-41 anti-influenza_Chain 534022-41 263-272 anti-influenza_Chain 5341 22-41 263-272anti-influenza_Chain 5342 22-41 anti-influenza_Chain 5343 22-41anti-influenza_Chain 5344 22-41 264-273 anti-influenza_Chain 5345 22-41264-273 anti-influenza_Chain 5346 22-41  96-105 anti-influenza_Chain5347 22-41  96-105 anti-influenza_Chain 5348 22-41  96-105anti-influenza_Chain 5349 22-41  96-105 anti-influenza_Chain 5350 22-41 96-105 anti-influenza_Chain 5351 22-41  96-105 anti-influenza_Chain5352 22-41 275-284 anti-influenza_Chain 5353 22-41 275-284anti-influenza_Chain 5354 22-41 34-43 anti-influenza_Chain 5355 22-4134-43 anti-influenza_Chain 5356 22-41 anti-influenza_Chain 5357 22-41anti-influenza_Chain 5358 22-41 509-518 anti-influenza_Chain 5359 22-41509-518 anti-influenza_Chain 5360 22-41 509-518 anti-influenza_Chain5361 22-41 509-518 anti-influenza_Chain 5362 22-41 509-518anti-influenza_Chain 5363 22-41 509-518 anti-influenza_Chain 5364 22-41509-518 anti-influenza_Chain 5365 22-41 509-518 anti-influenza_Chain5366 22-41 513-522 anti-influenza_Chain 5367 22-41 513-522anti-influenza_Chain 5368 22-41 513-522 anti-influenza_Chain 5369 22-41513-522 anti-influenza_Chain 5370 22-41 232-241 anti-influenza_Chain5371 22-41 232-241 anti-influenza_Chain 5372 22-41 209-218anti-influenza_Chain 5373 22-41 anti-influenza_Chain 5374 22-41anti-influenza_Chain 5375 22-41 209-218 anti-influenza_Chain 5376 22-41517-526 anti-influenza_Chain 5377 22-41 517-526 anti-influenza_Chain5378 22-41 anti-influenza_Chain 5379 22-41 anti-influenza_Chain 538022-41 anti-influenza_Chain 5381 22-41 519-528 anti-influenza_Chain 538222-41 519-528 anti-influenza_Chain 5383 22-41 anti-influenza_Chain 538422-41 anti-influenza_Chain 5385 22-41 anti-influenza_Chain 5386 22-41519-528 anti-influenza_Chain 5387 22-41 519-528 anti-influenza_Chain5388 22-41 164-173 anti-influenza_Chain 5389 22-41 anti-influenza_Chain5390 22-41 anti-influenza_Chain 5391 22-41 535-544 anti-influenza_Chain5392 22-41 164-173 anti-influenza_Chain 5393 22-41 anti-influenza_Chain5394 22-41 anti-influenza_Chain 5395 22-41 535-544 anti-influenza_Chain5396 22-41 anti-influenza_Chain 5397 22-41 14-23 anti-influenza_Chain5398 22-41 anti-influenza_Chain 5399 22-41 14-23 anti-influenza_Chain5400 22-41 525-534 anti-influenza_Chain 5401 22-41 525-534anti-influenza_Chain 5402 22-41 531-540 anti-influenza_Chain 5403 22-41531-540 anti-influenza_Chain 5404 22-41 529-538 anti-influenza_Chain5405 22-41 529-538 anti-influenza_Chain 5406 22-41 529-538anti-influenza_Chain 5407 22-41 151-160 anti-influenza_Chain 5408 22-41532-541 anti-influenza_Chain 5409 22-41 532-541 anti-influenza_Chain5410 22-41 532-541 anti-influenza_Chain 5411 22-41 532-541anti-influenza_Chain 5412 22-41 532-541 anti-influenza_Chain 5413 22-41532-541 anti-influenza_Chain 5414 22-41 61-70 anti-influenza_Chain 541522-41 61-70 anti-influenza_Chain 5416 22-41 151-160 anti-influenza_Chain5417 22-41 529-538 anti-influenza_Chain 5418 22-41 529-538anti-influenza_Chain 5419 22-41 529-538 anti-influenza_Chain 5420 22-41532-541 anti-influenza_Chain 5421 22-41 532-541 anti-influenza_Chain5422 22-41 532-541 anti-influenza_Chain 5423 22-41 532-541anti-influenza_Chain 5424 22-41 532-541 anti-influenza_Chain 5425 22-41532-541 anti-influenza_Chain 5426 22-41 248-257 anti-influenza_Chain5427 22-41 248-257 anti-influenza_Chain 5428 22-41 248-257anti-influenza_Chain 5429 22-41 248-257 anti-influenza_Chain 5430 22-41248-257 anti-influenza_Chain 5431 22-41 248-257 anti-influenza_Chain5432 22-41 248-257 anti-influenza_Chain 5433 22-41 533-542anti-influenza_Chain 5434 22-41 527-536 anti-influenza_Chain 5435 22-41527-536 anti-influenza_Chain 5436 22-41 533-542 anti-influenza_Chain5437 22-41 248-257 anti-influenza_Chain 5438 22-41 527-536anti-influenza_Chain 5439 22-41 527-536 anti-influenza_Chain 5440 22-41248-257 anti-influenza_Chain 5441 22-41 248-257 anti-influenza_Chain5442 22-41 248-257 anti-influenza_Chain 5443 22-41 248-257anti-influenza_Chain 5444 22-41 248-257 anti-influenza_Chain 5445 22-41248-257 anti-influenza_Chain 5446 22-41 529-538 anti-influenza_Chain5447 22-41 529-538 anti-influenza_Chain 5448 22-41 534-543anti-influenza_Chain 5449 22-41 534-543 anti-influenza_Chain 5450 22-41anti-influenza_Chain 5451 22-41 534-543 anti-influenza_Chain 5452 22-41anti-influenza_Chain 5453 22-41 529-538 anti-influenza_Chain 5454 22-41529-538 anti-influenza_Chain 5455 22-41 534-543 anti-influenza_Chain5456 22-41 534-543 anti-influenza_Chain 5457 22-41 534-543anti-influenza_Chain 5458 22-41 529-538 anti-influenza_Chain 5459 22-41535-544 anti-influenza_Chain 5460 22-41 529-538 anti-influenza_Chain5461 22-41 529-538 anti-influenza_Chain 5462 22-41 535-544anti-influenza_Chain 5463 22-41 529-538 anti-influenza_Chain 5464 22-41anti-influenza_Chain 5465 22-41 anti-influenza_Chain 5466 22-41anti-influenza_Chain 5467 22-41 232-241 anti-influenza_Chain 5468 22-41anti-influenza_Chain 5469 22-41 232-241 anti-influenza_Chain 5470 22-41anti-influenza_Chain 5471 22-41 488-497 anti-influenza_Chain 5472 22-41190-199 anti-influenza_Chain 5473 22-41 anti-influenza_Chain 5474 22-41488-497 anti-influenza_Chain 5475 22-41 190-199 anti-influenza_Chain5476 22-41 510-519 anti-influenza_Chain 5477 22-41 61-70anti-influenza_Chain 5478 22-41 510-519 anti-influenza_Chain 5479 22-4161-70 anti-influenza_Chain 5480 22-41 anti-influenza_Chain 5481 22-41anti-influenza_Chain 5482 22-41 anti-influenza_Chain 5483 22-41anti-influenza_Chain 5484 22-41 anti-influenza_Chain 5485 22-41anti-influenza_Chain 5486 22-41 513-522 anti-influenza_Chain 5487 22-41anti-influenza_Chain 5488 22-41 190-199 anti-influenza_Chain 5489 22-41513-522 anti-influenza_Chain 5490 22-41 anti-influenza_Chain 5491 22-41190-199 anti-influenza_Chain 5492 22-41 anti-influenza_Chain 5493 22-41anti-influenza_Chain 5494 22-41 anti-influenza_Chain 5495 22-41anti-influenza_Chain 5496 22-41 538-547 anti-influenza_Chain 5497 22-41538-547 anti-influenza_Chain 5498 22-41 anti-influenza_Chain 5499 22-41anti-influenza_Chain 5500 22-41 anti-influenza_Chain 5501 22-41anti-influenza_Chain 5502 22-41 anti-influenza_Chain 5503 22-41anti-influenza_Chain 5504 22-41 anti-influenza_Chain 5505 22-41anti-influenza_Chain 5506 22-41 anti-influenza_Chain 5507 22-41anti-influenza_Chain 5508 22-41 anti-influenza_Chain 5509 22-41anti-influenza_Chain 5510 22-41 anti-influenza_Chain 5511 22-41anti-influenza_Chain 5512 22-41 anti-influenza_Chain 5513 22-41anti-influenza_Chain 5514 22-41 anti-influenza_Chain 5515 22-41 565-574anti-influenza_Chain 5516 22-41 anti-influenza_Chain 5517 22-41 565-574anti-influenza_Chain 5518 22-41 108-117 anti-influenza_Chain 5519 22-41108-117 anti-influenza_Chain 5520 22-41  5-14 anti-influenza_Chain 552122-41  5-14 anti-influenza_Chain 5522 22-41 116-125 anti-influenza_Chain5523 22-41 116-125 anti-influenza_Chain 5524 22-41 129-138anti-influenza_Chain 5525 22-41 129-138 anti-influenza_Chain 5526 22-41anti-influenza_Chain 5527 22-41 anti-influenza_Chain 5528 22-41 178-187anti-influenza_Chain 5529 22-41 178-187 anti-influenza_Chain 5530 22-41114-123 anti-influenza_Chain 5531 22-41 114-123 anti-influenza_Chain5532 22-41 184-193 anti-influenza_Chain 5533 22-41 184-193anti-influenza_Chain 5534 22-41 anti-influenza_Chain 5535 22-41anti-influenza_Chain 5536 22-41 554-563 anti-influenza_Chain 5537 22-41554-563 anti-influenza_Chain 5538 22-41 206-215 anti-influenza_Chain5539 22-41 206-215 anti-0X40_LightChain 5540 22-41 48-57 86-105anti-0X40_LightChain 5541 22-41 48-57 86-105 anti-0X40_LightChain 554222-41 48-57 86-105 anti-0X40_LightChain 5543 22-41 48-57 86-105anti-0X40_LightChain 5544 22-41 48-57 anti-0X40_LightChain 5545 22-4148-57 86-105 anti-0X40_LightChain 5546 22-41 48-57 86-105anti-0X40_LightChain 5547 22-41 48-57 86-105 anti-0X40_LightChain 554822-41 48-57 86-105 anti-0X40_LightChain 5549 22-41 48-57 86-105anti-0X40_LightChain 5550 22-41 48-57 86-105 anti-0X40_LightChain 555122-41 48-57 86-105 anti-0X40_LightChain 5552 22-41 48-57 86-105anti-0X40_LightChain 5553 22-41 48-57 86-105 anti-0X40_HeavyChain 555422-41 94-113 anti-0X40_HeavyChain 5555 22-41 94-113 anti-0X40_HeavyChain5556 22-41 94-113 anti-0X40_HeavyChain 5557 22-41 94-113anti-0X40_HeavyChain 5558 22-41 94-113 anti-0X40_HeavyChain 5559 22-4194-113 anti-0X40_HeavyChain 5560 22-41 94-113 anti-0X40_HeavyChain 556122-41 94-113 anti-0X40_HeavyChain 5562 22-41 94-113 anti-0X40_HeavyChain5563 22-41 94-113 anti-0X40_HeavyChain 5564 22-41 94-113anti-0X40_HeavyChain 5565 22-41 94-113 anti-0X40_HeavyChain 5566 22-4194-113 anti-0X40_HeavyChain 5567 22-41 94-113 anti-0X40_HeavyChain 556822-41 94-113 anti-0X40_HeavyChain 5569 22-41 94-113 anti-0X40_HeavyChain5570 22-41 93-112 anti-0X40_HeavyChain 5571 22-41 93-112anti-0X40_HeavyChain 5572 22-41 anti-0X40_HeavyChain 5573 22-41anti-0X40_HeavyChain 5574 22-41 anti-0X40_HeavyChain 5575 22-41 93-112anti-0X40_HeavyChain 5576 22-41 93-112 anti-0X40_HeavyChain 5577 22-41anti-0X40_HeavyChain 5578 22-41 anti-0X40_HeavyChain 5579 22-41 93-112anti-0X40_HeavyChain 5580 22-41 93-112 anti-0X40_HeavyChain 5581 22-4193-112 anti-0X40_HeavyChain 5582 22-41 93-112 anti-0X40_HeavyChain 558322-41 93-112 anti-0X40_HeavyChain 5584 22-41 93-112 anti-0X40_HeavyChain5585 22-41 93-112 anti-0X40_HeavyChain 5586 22-41 anti-0X40_HeavyChain5587 22-41 93-112 anti-0X40_HeavyChain 5588 22-41 94-113anti-0X40_LightChain 5589 22-41 69-78 107-126  anti-0X40_LightChain 559022-41 68-77 106-125  anti-0X40_LightChain 5591 22-41 68-77 106-125 anti-0X40_LightChain 5592 22-41 69-78 107-126  anti-0X40_LightChain 559322-41 70-79 108-127  anti-0X40_HeavyChain 5594 22-41 114-133 anti-0X40_HeavyChain 5595 22-41 72-81 114-133  anti-0X40_HeavyChain 559622-41 77-86 113-132  anti-0X40_HeavyChain 5597 22-41 72-81 114-133 anti-0X40_HeavyChain 5598 22-41 129-148  anti-0X40_LightChain 5599 22-4148-57 86-105 anti-0X40_HeavyChain 5600 22-41 94-113

Accordingly, it is preferred that the at least one coding sequenceencodes a complementarity determining region (CDR) of an antibody.Preferably, the CDR encoded by the at least one coding sequencecomprises or consists of an amino acid sequence as described in Table 5above.

It is also preferred that the CDR encoded by the at least one codingsequence comprises or consists of an amino acid sequence as described inTable 6 below (referred to as “protein SEQ ID NO”). Particularlypreferably, the at least one coding sequence comprises or consists of anucleic acid sequence (RNA sequence) as described in Table 6 below(referred to as “RNA SEQ ID NO”).

TABLE 6 Overview over the SEQ ID NOs of the amino acid sequences ofpreferred exemplary CDRs and of the respective encoding RNA sequences.Protein Name SEQ ID NO: RNA SEQ ID NO:anti-HIV_VRC01_VRC02_NIH45-46_LightChain_CDR 5601 13243, 20885, 28527,36169, 43811, 51453, 59095 anti-HIV_VRC01_HeavyChain_CDR 5602 13244,20886, 28528, 36170, 43812, 51454, 59096 anti-HIV_3BNC60_LightChain_CDR5603 13245, 20887, 28529, 36171, 43813, 51455, 59097anti-HIV_3BNC60_HeavyChain_CDR 5604 13246, 20888, 28530, 36172, 43814,51456, 59098 anti-HIV_5H/I1-BMV-D5_HeavyChain_CDR 5605 13247, 20889,28531, 36173, 43815, 51457, 59099 anti-HIV_8ANC195_LightChain_CDR 560613248, 20890, 28532, 36174, 43816, 51458, 59100anti-HIV_CH01_CH02_CH03_LightChain_CDR 5607 13249, 20891, 28533, 36175,43817, 51459, 59101 anti-HIV_CH01_HeavyChain_CDR 5608 13250, 20892,28534, 36176, 43818, 51460, 59102 anti-HIV_CH02_HeavyChain_CDR 560913251, 20893, 28535, 36177, 43819, 51461, 59103anti-HIV_CH03_HeavyChain_CDR 5610 13252, 20894, 28536, 36178, 43820,51462, 59104 anti-HIV_CH04_LightChain_CDR 5611 13253, 20895, 28537,36179, 43821, 51463, 59105 anti-HIV_CH04_HeavyChain_CDR 5612 13254,20896, 28538, 36180, 43822, 51464, 59106anti-HIV_NIH45-46_HeavyChain_CDR 5613 13255, 20897, 28539, 36181, 43823,51465, 59107 anti-HIV_PG16_HeavyChain_CDR 5614 13256, 20898, 28540,36182, 43824, 51466, 59108 anti-HIV_PGT122_LightChain_CDR 5615 13257,20899, 28541, 36183, 43825, 51467, 59109 anti-HIV_PGT122_HeavyChain_CDR5616 13258, 20900, 28542, 36184, 43826, 51468, 59110anti-HIV_PGT123_LightChain_CDR 5617 13259, 20901, 28543, 36185, 43827,51469, 59111 anti-HIV_PGT123_HeavyChain_CDR 5618 13260, 20902, 28544,36186, 43828, 51470, 59112 anti-HIV_PGT125_PGT128_LightChain_CDR 561913261, 20903, 28545, 36187, 43829, 51471, 59113anti-HIV_PGT125_HeavyChain_CDR 5620 13262, 20904, 28546, 36188, 43830,51472, 59114 anti-HIV_PGT126_PGT127_LightChain_CDR 5621 13263, 20905,28547, 36189, 43831, 51473, 59115 anti-HIV_PGT126_HeavyChain_CDR 562213264, 20906, 28548, 36190, 43832, 51474, 59116anti-HIV_PGT127_HeavyChain_CDR 5623 13265, 20907, 28549, 36191, 43833,51475, 59117 anti-HIV_PGT128_HeavyChain_CDR 5624 13266, 20908, 28550,36192, 43834, 51476, 59118 anti-HIV_PGT130_LightChain_CDR 5625 13267,20909, 28551, 36193, 43835, 51477, 59119 anti-HIV_PGT130_HeavyChain_CDR5626 13268, 20910, 28552, 36194, 43836, 51478, 59120anti-HIV_PGT131_LightChain_CDR 5627 13269, 20911, 28553, 36195, 43837,51479, 59121 anti-HIV_PGT131_HeavyChain_CDR 5628 13270, 20912, 28554,36196, 43838, 51480, 59122 anti-HIV_PGT135_PGT136_PGT137_LightChain_CDR5629 13271, 20913, 28555, 36197, 43839, 51481, 59123anti-HIV_PGT135_HeavyChain_CDR 5630 13272, 20914, 28556, 36198, 43840,51482, 59124 anti-HIV_PGT136_HeavyChain_CDR 5631 13273, 20915, 28557,36199, 43841, 51483, 59125 anti-HIV_PGT137_HeavyChain_CDR 5632 13274,20916, 28558, 36200, 43842, 51484, 59126anti-HIV_PGT141_PGT142_PGT143_PGT144_LightChain_CDR 5633 13275, 20917,28559, 36201, 43843, 51485, 59127 anti-HIV_PGT141_HeavyChain_CDR 563413276, 20918, 28560, 36202, 43844, 51486, 59128anti-HIV_PGT144_HeavyChain_CDR 5635 13277, 20919, 28561, 36203, 43845,51487, 59129 anti-HIV_PGT145_LightChain_CDR 5636 13278, 20920, 28562,36204, 43846, 51488, 59130 anti-HIV_PGT145_HeavyChain_CDR 5637 13279,20921, 28563, 36205, 43847, 51489, 59131anti-HIV_VRC-CH30_VRC-CH31_VRC-CH32_VRC- 5638 13280, 20922, 28564,36206, 43848, 51490, 59132 CH33_VRC-CH34_LightChain_CDRanti-HIV_VRC-CH30_VRC-CH31_VRC-CH32_VRC- 5639 13281, 20923, 28565,36207, 43849, 51491, 59133 CH34_HeavyChain_CDRanti-HIV_VRC-CH33_HeavyChain_CDR 5640 13282, 20924, 28566, 36208, 43850,51492, 59134 anti-HIV_VRC-PG04_LightChain_CDR 5641 13283, 20925, 28567,36209, 43851, 51493, 59135 anti-HIV_VRC-PG04_HeavyChain_CDR 5642 13284,20926, 28568, 36210, 43852, 51494, 59136anti-HIV_VRC-PG04b_LightChain_CDR 5643 13285, 20927, 28569, 36211,43853, 51495, 59137 anti-HIV_VRC-PG04b_HeavyChain_CDR 5644 13286, 20928,28570, 36212, 43854, 51496, 59138 anti-HIV_VRC03_LightChain_CDR 564513287, 20929, 28571, 36213, 43855, 51497, 59139anti-HIV_VRC03_HeavyChain_CDR 5646 13288, 20930, 28572, 36214, 43856,51498, 59140 anti-HIV_1TJG_P-Chain 5647 13289, 20931, 28573, 36215,43857, 51499, 59141 anti-HIV_2B1H_P-Chain 5648 13290, 20932, 28574,36216, 43858, 51500, 59142 anti-HIV_2B1A_P-Chain 5649 13291, 20933,28575, 36217, 43859, 51501, 59143 anti-HIV_2B0S_P-Chain 5650 13292,20934, 28576, 36218, 43860, 51502, 59144 anti-HIV_3UJJ_P-Chain 565113293, 20935, 28577, 36219, 43861, 51503, 59145 anti-HIV_3UJI_P-Chain5652 13294, 20936, 28578, 36220, 43862, 51504, 59146anti-HIV_3MLZ_P-Chain 5653 13295, 20937, 28579, 36221, 43863, 51505,59147 anti-HIV_3MLV_Q-Chain 5654 13296, 20938, 28580, 36222, 43864,51506, 59148 anti-HIV_3MLU_P-Chain 5655 13297, 20939, 28581, 36223,43865, 51507, 59149 anti-HIV_3MLR_P-Chain 5656 13298, 20940, 28582,36224, 43866, 51508, 59150 anti-HIV_4XCF_P-Chain 5657 13299, 20941,28583, 36225, 43867, 51509, 59151 anti-HIV_4XBE_P-Chain 5658 13300,20942, 28584, 36226, 43868, 51510, 59152 anti-HIV_4XAW_P-Chain 565913301, 20943, 28585, 36227, 43869, 51511, 59153 anti-HIV_2QSC_P-Chain5660 13302, 20944, 28586, 36228, 43870, 51512, 59154anti-HIV_3MLS_S-Chain 5661 13303, 20945, 28587, 36229, 43871, 51513,59155 anti-HIV_3G01_P-Chain 5662 13304, 20946, 28588, 36230, 43872,51514, 59156 anti-HIV_4MID_Q-Chain 5663 13305, 20947, 28589, 36231,43873, 51515, 59157 anti-HIV_3C2A_Q-Chain 5664 13306, 20948, 28590,36232, 43874, 51516, 59158 anti-HIV_CDR 5665 13307, 20949, 28591, 36233,43875, 51517, 59159 anti-HIV_CDR 5666 13308, 20950, 28592, 36234, 43876,51518, 59160 anti-HIV_CDR 5667 13309, 20951, 28593, 36235, 43877, 51519,59161 anti-HIV_CDR 5668 13310, 20952, 28594, 36236, 43878, 51520, 59162anti-HIV_CDR 5669 13311, 20953, 28595, 36237, 43879, 51521, 59163anti-HIV_CDR 5670 13312, 20954, 28596, 36238, 43880, 51522, 59164anti-HIV_CDR 5671 13313, 20955, 28597, 36239, 43881, 51523, 59165anti-HIV_CDR 5672 13314, 20956, 28598, 36240, 43882, 51524, 59166anti-HIV_CDR 5673 13315, 20957, 28599, 36241, 43883, 51525, 59167anti-HIV_CDR 5674 13316, 20958, 28600, 36242, 43884, 51526, 59168anti-HIV_CDR 5675 13317, 20959, 28601, 36243, 43885, 51527, 59169anti-HIV_CDR 5676 13318, 20960, 28602, 36244, 43886, 51528, 59170anti-HIV_CDR 5677 13319, 20961, 28603, 36245, 43887, 51529, 59171anti-HIV_CDR 5678 13320, 20962, 28604, 36246, 43888, 51530, 59172anti-HIV_CDR 5679 13321, 20963, 28605, 36247, 43889, 51531, 59173anti-HIV_CDR 5680 13322, 20964, 28606, 36248, 43890, 51532, 59174anti-HIV_CDR 5681 13323, 20965, 28607, 36249, 43891, 51533, 59175anti-HIV_CDR 5682 13324, 20966, 28608, 36250, 43892, 51534, 59176anti-HIV_CDR 5683 13325, 20967, 28609, 36251, 43893, 51535, 59177anti-HIV_CDR 5684 13326, 20968, 28610, 36252, 43894, 51536, 59178anti-HIV_CDR 5685 13327, 20969, 28611, 36253, 43895, 51537, 59179anti-HIV_CDR 5686 13328, 20970, 28612, 36254, 43896, 51538, 59180anti-HIV_CDR 5687 13329, 20971, 28613, 36255, 43897, 51539, 59181anti-HIV_CDR 5688 13330, 20972, 28614, 36256, 43898, 51540, 59182anti-HIV_CDR 5689 13331, 20973, 28615, 36257, 43899, 51541, 59183anti-HIV_CDR 5690 13332, 20974, 28616, 36258, 43900, 51542, 59184anti-HIV_CDR 5691 13333, 20975, 28617, 36259, 43901, 51543, 59185anti-HIV_CDR 5692 13334, 20976, 28618, 36260, 43902, 51544, 59186anti-HIV_CDR 5693 13335, 20977, 28619, 36261, 43903, 51545, 59187anti-HIV_CDR 5694 13336, 20978, 28620, 36262, 43904, 51546, 59188anti-HIV_CDR 5695 13337, 20979, 28621, 36263, 43905, 51547, 59189anti-HIV_CDR 5696 13338, 20980, 28622, 36264, 43906, 51548, 59190anti-HIV_CDR 5697 13339, 20981, 28623, 36265, 43907, 51549, 59191anti-HIV_CDR 5698 13340, 20982, 28624, 36266, 43908, 51550, 59192anti-HIV_CDR 5699 13341, 20983, 28625, 36267, 43909, 51551, 59193anti-HIV_CDR 5700 13342, 20984, 28626, 36268, 43910, 51552, 59194anti-HIV_CDR 5701 13343, 20985, 28627, 36269, 43911, 51553, 59195anti-HIV_CDR 5702 13344, 20986, 28628, 36270, 43912, 51554, 59196anti-HIV_CDR 5703 13345, 20987, 28629, 36271, 43913, 51555, 59197anti-HIV_CDR 5704 13346, 20988, 28630, 36272, 43914, 51556, 59198anti-HIV_CDR 5705 13347, 20989, 28631, 36273, 43915, 51557, 59199anti-HIV_CDR 5706 13348, 20990, 28632, 36274, 43916, 51558, 59200anti-HIV_CDR 5707 13349, 20991, 28633, 36275, 43917, 51559, 59201anti-HIV_CDR 5708 13350, 20992, 28634, 36276, 43918, 51560, 59202anti-HIV_CDR 5709 13351, 20993, 28635, 36277, 43919, 51561, 59203anti-HIV_CDR 5710 13352, 20994, 28636, 36278, 43920, 51562, 59204anti-HIV_CDR 5711 13353, 20995, 28637, 36279, 43921, 51563, 59205anti-HIV_CDR 5712 13354, 20996, 28638, 36280, 43922, 51564, 59206anti-HIV_CDR 5713 13355, 20997, 28639, 36281, 43923, 51565, 59207anti-HIV_CDR 5714 13356, 20998, 28640, 36282, 43924, 51566, 59208anti-HIV_CDR 5715 13357, 20999, 28641, 36283, 43925, 51567, 59209anti-HIV_CDR 5716 13358, 21000, 28642, 36284, 43926, 51568, 59210anti-HIV_CDR 5717 13359, 21001, 28643, 36285, 43927, 51569, 59211anti-HIV_CDR 5718 13360, 21002, 28644, 36286, 43928, 51570, 59212anti-HIV_CDR 5719 13361, 21003, 28645, 36287, 43929, 51571, 59213anti-HIV_CDR 5720 13362, 21004, 28646, 36288, 43930, 51572, 59214anti-HIV_CDR 5721 13363, 21005, 28647, 36289, 43931, 51573, 59215anti-HIV_CDR 5722 13364, 21006, 28648, 36290, 43932, 51574, 59216anti-HIV_CDR 5723 13365, 21007, 28649, 36291, 43933, 51575, 59217anti-HIV_CDR 5724 13366, 21008, 28650, 36292, 43934, 51576, 59218anti-HIV_CDR 5725 13367, 21009, 28651, 36293, 43935, 51577, 59219anti-HIV_CDR 5726 13368, 21010, 28652, 36294, 43936, 51578, 59220anti-HIV_CDR 5727 13369, 21011, 28653, 36295, 43937, 51579, 59221anti-HIV_CDR 5728 13370, 21012, 28654, 36296, 43938, 51580, 59222anti-HIV_CDR 5729 13371, 21013, 28655, 36297, 43939, 51581, 59223anti-HIV_CDR 5730 13372, 21014, 28656, 36298, 43940, 51582, 59224anti-HIV_CDR 5731 13373, 21015, 28657, 36299, 43941, 51583, 59225anti-HIV_CDR 5732 13374, 21016, 28658, 36300, 43942, 51584, 59226anti-HIV_CDR 5733 13375, 21017, 28659, 36301, 43943, 51585, 59227anti-HIV_CDR 5734 13376, 21018, 28660, 36302, 43944, 51586, 59228anti-HIV_CDR 5735 13377, 21019, 28661, 36303, 43945, 51587, 59229anti-HIV_CDR 5736 13378, 21020, 28662, 36304, 43946, 51588, 59230anti-HIV_CDR 5737 13379, 21021, 28663, 36305, 43947, 51589, 59231anti-HIV_CDR 5738 13380, 21022, 28664, 36306, 43948, 51590, 59232anti-HIV_CDR 5739 13381, 21023, 28665, 36307, 43949, 51591, 59233anti-HIV_CDR 5740 13382, 21024, 28666, 36308, 43950, 51592, 59234anti-HIV_CDR 5741 13383, 21025, 28667, 36309, 43951, 51593, 59235anti-HIV_CDR 5742 13384, 21026, 28668, 36310, 43952, 51594, 59236anti-HIV_CDR 5743 13385, 21027, 28669, 36311, 43953, 51595, 59237anti-HIV_CDR 5744 13386, 21028, 28670, 36312, 43954, 51596, 59238anti-HIV_CDR 5745 13387, 21029, 28671, 36313, 43955, 51597, 59239anti-HIV_CDR 5746 13388, 21030, 28672, 36314, 43956, 51598, 59240anti-HIV_CDR 5747 13389, 21031, 28673, 36315, 43957, 51599, 59241anti-HIV_CDR 5748 13390, 21032, 28674, 36316, 43958, 51600, 59242anti-HIV_CDR 5749 13391, 21033, 28675, 36317, 43959, 51601, 59243anti-HIV_CDR 5750 13392, 21034, 28676, 36318, 43960, 51602, 59244anti-HIV_CDR 5751 13393, 21035, 28677, 36319, 43961, 51603, 59245anti-HIV_CDR 5752 13394, 21036, 28678, 36320, 43962, 51604, 59246anti-HIV_CDR 5753 13395, 21037, 28679, 36321, 43963, 51605, 59247anti-HIV_CDR 5754 13396, 21038, 28680, 36322, 43964, 51606, 59248anti-HIV_CDR 5755 13397, 21039, 28681, 36323, 43965, 51607, 59249anti-HIV_CDR 5756 13398, 21040, 28682, 36324, 43966, 51608, 59250anti-HIV_CDR 5757 13399, 21041, 28683, 36325, 43967, 51609, 59251anti-HIV_CDR 5758 13400, 21042, 28684, 36326, 43968, 51610, 59252anti-HIV_CDR 5759 13401, 21043, 28685, 36327, 43969, 51611, 59253anti-HIV_CDR 5760 13402, 21044, 28686, 36328, 43970, 51612, 59254anti-HIV_CDR 5761 13403, 21045, 28687, 36329, 43971, 51613, 59255anti-HIV_CDR 5762 13404, 21046, 28688, 36330, 43972, 51614, 59256anti-HIV_CDR 5763 13405, 21047, 28689, 36331, 43973, 51615, 59257anti-HIV_CDR 5764 13406, 21048, 28690, 36332, 43974, 51616, 59258anti-HIV_CDR 5765 13407, 21049, 28691, 36333, 43975, 51617, 59259anti-HIV_CDR 5766 13408, 21050, 28692, 36334, 43976, 51618, 59260anti-HIV_CDR 5767 13409, 21051, 28693, 36335, 43977, 51619, 59261anti-HIV_CDR 5768 13410, 21052, 28694, 36336, 43978, 51620, 59262anti-HIV_CDR 5769 13411, 21053, 28695, 36337, 43979, 51621, 59263anti-HIV_CDR 5770 13412, 21054, 28696, 36338, 43980, 51622, 59264anti-HIV_CDR 5771 13413, 21055, 28697, 36339, 43981, 51623, 59265anti-HIV_CDR 5772 13414, 21056, 28698, 36340, 43982, 51624, 59266anti-HIV_CDR 5773 13415, 21057, 28699, 36341, 43983, 51625, 59267anti-HIV_CDR 5774 13416, 21058, 28700, 36342, 43984, 51626, 59268anti-HIV_CDR 5775 13417, 21059, 28701, 36343, 43985, 51627, 59269anti-HIV_CDR 5776 13418, 21060, 28702, 36344, 43986, 51628, 59270anti-HIV_CDR 5777 13419, 21061, 28703, 36345, 43987, 51629, 59271anti-HIV_CDR 5778 13420, 21062, 28704, 36346, 43988, 51630, 59272anti-HIV_CDR 5779 13421, 21063, 28705, 36347, 43989, 51631, 59273anti-HIV_CDR 5780 13422, 21064, 28706, 36348, 43990, 51632, 59274anti-HIV_CDR 5781 13423, 21065, 28707, 36349, 43991, 51633, 59275anti-HIV_CDR 5782 13424, 21066, 28708, 36350, 43992, 51634, 59276anti-HIV_CDR 5783 13425, 21067, 28709, 36351, 43993, 51635, 59277anti-HIV_CDR 5784 13426, 21068, 28710, 36352, 43994, 51636, 59278anti-HIV_CDR 5785 13427, 21069, 28711, 36353, 43995, 51637, 59279anti-HIV_CDR 5786 13428, 21070, 28712, 36354, 43996, 51638, 59280anti-HIV_CDR 5787 13429, 21071, 28713, 36355, 43997, 51639, 59281anti-HIV_CDR 5788 13430, 21072, 28714, 36356, 43998, 51640, 59282anti-HIV_CDR 5789 13431, 21073, 28715, 36357, 43999, 51641, 59283anti-HIV_CDR 5790 13432, 21074, 28716, 36358, 44000, 51642, 59284anti-HIV_CDR 5791 13433, 21075, 28717, 36359, 44001, 51643, 59285anti-HIV_CDR 5792 13434, 21076, 28718, 36360, 44002, 51644, 59286anti-HIV_CDR 5793 13435, 21077, 28719, 36361, 44003, 51645, 59287anti-HIV_CDR 5794 13436, 21078, 28720, 36362, 44004, 51646, 59288anti-HIV_CDR 5795 13437, 21079, 28721, 36363, 44005, 51647, 59289anti-HIV_CDR 5796 13438, 21080, 28722, 36364, 44006, 51648, 59290anti-HIV_CDR 5797 13439, 21081, 28723, 36365, 44007, 51649, 59291anti-HIV_CDR 5798 13440, 21082, 28724, 36366, 44008, 51650, 59292anti-HIV_CDR 5799 13441, 21083, 28725, 36367, 44009, 51651, 59293anti-HIV_CDR 5800 13442, 21084, 28726, 36368, 44010, 51652, 59294anti-HIV_CDR 5801 13443, 21085, 28727, 36369, 44011, 51653, 59295anti-HIV_CDR 5802 13444, 21086, 28728, 36370, 44012, 51654, 59296anti-HIV_CDR 5803 13445, 21087, 28729, 36371, 44013, 51655, 59297anti-HIV_CDR 5804 13446, 21088, 28730, 36372, 44014, 51656, 59298anti-HIV_CDR 5805 13447, 21089, 28731, 36373, 44015, 51657, 59299anti-HIV_CDR 5806 13448, 21090, 28732, 36374, 44016, 51658, 59300anti-HIV_CDR 5807 13449, 21091, 28733, 36375, 44017, 51659, 59301anti-HIV_CDR 5808 13450, 21092, 28734, 36376, 44018, 51660, 59302anti-HIV_CDR 5809 13451, 21093, 28735, 36377, 44019, 51661, 59303anti-HIV_CDR 5810 13452, 21094, 28736, 36378, 44020, 51662, 59304anti-HIV_CDR 5811 13453, 21095, 28737, 36379, 44021, 51663, 59305anti-HIV_CDR 5812 13454, 21096, 28738, 36380, 44022, 51664, 59306anti-HIV_CDR 5813 13455, 21097, 28739, 36381, 44023, 51665, 59307anti-HIV_CDR 5814 13456, 21098, 28740, 36382, 44024, 51666, 59308anti-HIV_CDR 5815 13457, 21099, 28741, 36383, 44025, 51667, 59309anti-HIV_CDR 5816 13458, 21100, 28742, 36384, 44026, 51668, 59310anti-HIV_CDR 5817 13459, 21101, 28743, 36385, 44027, 51669, 59311anti-HIV_CDR 5818 13460, 21102, 28744, 36386, 44028, 51670, 59312anti-HIV_CDR 5819 13461, 21103, 28745, 36387, 44029, 51671, 59313anti-HIV_CDR 5820 13462, 21104, 28746, 36388, 44030, 51672, 59314anti-HIV_CDR 5821 13463, 21105, 28747, 36389, 44031, 51673, 59315anti-HIV_CDR 5822 13464, 21106, 28748, 36390, 44032, 51674, 59316anti-HIV_CDR 5823 13465, 21107, 28749, 36391, 44033, 51675, 59317anti-HIV_CDR 5824 13466, 21108, 28750, 36392, 44034, 51676, 59318anti-HIV_CDR 5825 13467, 21109, 28751, 36393, 44035, 51677, 59319anti-HIV_CDR 5826 13468, 21110, 28752, 36394, 44036, 51678, 59320anti-HIV_CDR 5827 13469, 21111, 28753, 36395, 44037, 51679, 59321anti-HIV_CDR 5828 13470, 21112, 28754, 36396, 44038, 51680, 59322anti-HIV_CDR 5829 13471, 21113, 28755, 36397, 44039, 51681, 59323anti-HIV_CDR 5830 13472, 21114, 28756, 36398, 44040, 51682, 59324anti-HIV_CDR 5831 13473, 21115, 28757, 36399, 44041, 51683, 59325anti-HIV_CDR 5832 13474, 21116, 28758, 36400, 44042, 51684, 59326anti-HIV_CDR 5833 13475, 21117, 28759, 36401, 44043, 51685, 59327anti-HIV_CDR 5834 13476, 21118, 28760, 36402, 44044, 51686, 59328anti-HIV_CDR 5835 13477, 21119, 28761, 36403, 44045, 51687, 59329anti-HIV_CDR 5836 13478, 21120, 28762, 36404, 44046, 51688, 59330anti-HIV_CDR 5837 13479, 21121, 28763, 36405, 44047, 51689, 59331anti-HIV_CDR 5838 13480, 21122, 28764, 36406, 44048, 51690, 59332anti-HIV_CDR 5839 13481, 21123, 28765, 36407, 44049, 51691, 59333anti-HIV_CDR 5840 13482, 21124, 28766, 36408, 44050, 51692, 59334anti-HIV_CDR 5841 13483, 21125, 28767, 36409, 44051, 51693, 59335anti-HIV_CDR 5842 13484, 21126, 28768, 36410, 44052, 51694, 59336anti-HIV_CDR 5843 13485, 21127, 28769, 36411, 44053, 51695, 59337anti-HIV_CDR 5844 13486, 21128, 28770, 36412, 44054, 51696, 59338anti-HIV_CDR 5845 13487, 21129, 28771, 36413, 44055, 51697, 59339anti-HIV_CDR 5846 13488, 21130, 28772, 36414, 44056, 51698, 59340anti-HIV_CDR 5847 13489, 21131, 28773, 36415, 44057, 51699, 59341anti-HIV_CDR 5848 13490, 21132, 28774, 36416, 44058, 51700, 59342anti-HIV_CDR 5849 13491, 21133, 28775, 36417, 44059, 51701, 59343anti-HIV_CDR 5850 13492, 21134, 28776, 36418, 44060, 51702, 59344anti-HIV_CDR 5851 13493, 21135, 28777, 36419, 44061, 51703, 59345anti-HIV_CDR 5852 13494, 21136, 28778, 36420, 44062, 51704, 59346anti-HIV_CDR 5853 13495, 21137, 28779, 36421, 44063, 51705, 59347anti-HIV_CDR 5854 13496, 21138, 28780, 36422, 44064, 51706, 59348anti-HIV_CDR 5855 13497, 21139, 28781, 36423, 44065, 51707, 59349anti-HIV_CDR 5856 13498, 21140, 28782, 36424, 44066, 51708, 59350anti-HIV_CDR 5857 13499, 21141, 28783, 36425, 44067, 51709, 59351anti-HIV_CDR 5858 13500, 21142, 28784, 36426, 44068, 51710, 59352anti-HIV_CDR 5859 13501, 21143, 28785, 36427, 44069, 51711, 59353anti-HIV_CDR 5860 13502, 21144, 28786, 36428, 44070, 51712, 59354anti-HIV_CDR 5861 13503, 21145, 28787, 36429, 44071, 51713, 59355anti-HIV_CDR 5862 13504, 21146, 28788, 36430, 44072, 51714, 59356anti-HIV_CDR 5863 13505, 21147, 28789, 36431, 44073, 51715, 59357anti-HIV_CDR 5864 13506, 21148, 28790, 36432, 44074, 51716, 59358anti-HIV_CDR 5865 13507, 21149, 28791, 36433, 44075, 51717, 59359anti-HIV_CDR 5866 13508, 21150, 28792, 36434, 44076, 51718, 59360anti-HIV_CDR 5867 13509, 21151, 28793, 36435, 44077, 51719, 59361anti-HIV_CDR 5868 13510, 21152, 28794, 36436, 44078, 51720, 59362anti-HIV_CDR 5869 13511, 21153, 28795, 36437, 44079, 51721, 59363anti-HIV_CDR 5870 13512, 21154, 28796, 36438, 44080, 51722, 59364anti-HIV_CDR 5871 13513, 21155, 28797, 36439, 44081, 51723, 59365anti-HIV_CDR 5872 13514, 21156, 28798, 36440, 44082, 51724, 59366anti-HIV_CDR 5873 13515, 21157, 28799, 36441, 44083, 51725, 59367anti-HIV_CDR 5874 13516, 21158, 28800, 36442, 44084, 51726, 59368anti-HIV_CDR 5875 13517, 21159, 28801, 36443, 44085, 51727, 59369anti-HIV_CDR 5876 13518, 21160, 28802, 36444, 44086, 51728, 59370anti-HIV_CDR 5877 13519, 21161, 28803, 36445, 44087, 51729, 59371anti-HIV_CDR 5878 13520, 21162, 28804, 36446, 44088, 51730, 59372anti-HIV_CDR 5879 13521, 21163, 28805, 36447, 44089, 51731, 59373anti-HIV_CDR 5880 13522, 21164, 28806, 36448, 44090, 51732, 59374anti-HIV_CDR 5881 13523, 21165, 28807, 36449, 44091, 51733, 59375anti-HIV_CDR 5882 13524, 21166, 28808, 36450, 44092, 51734, 59376anti-HIV_CDR 5883 13525, 21167, 28809, 36451, 44093, 51735, 59377anti-HIV_CDR 5884 13526, 21168, 28810, 36452, 44094, 51736, 59378anti-HIV_CDR 5885 13527, 21169, 28811, 36453, 44095, 51737, 59379anti-HIV_CDR 5886 13528, 21170, 28812, 36454, 44096, 51738, 59380anti-HIV_CDR 5887 13529, 21171, 28813, 36455, 44097, 51739, 59381anti-HIV_CDR 5888 13530, 21172, 28814, 36456, 44098, 51740, 59382anti-HIV_CDR 5889 13531, 21173, 28815, 36457, 44099, 51741, 59383anti-HIV_CDR 5890 13532, 21174, 28816, 36458, 44100, 51742, 59384anti-HIV_CDR 5891 13533, 21175, 28817, 36459, 44101, 51743, 59385anti-HIV_CDR 5892 13534, 21176, 28818, 36460, 44102, 51744, 59386anti-HIV_CDR 5893 13535, 21177, 28819, 36461, 44103, 51745, 59387anti-HIV_CDR 5894 13536, 21178, 28820, 36462, 44104, 51746, 59388anti-HIV_CDR 5895 13537, 21179, 28821, 36463, 44105, 51747, 59389anti-HIV_CDR 5896 13538, 21180, 28822, 36464, 44106, 51748, 59390anti-HIV_CDR 5897 13539, 21181, 28823, 36465, 44107, 51749, 59391anti-HIV_CDR 5898 13540, 21182, 28824, 36466, 44108, 51750, 59392anti-HIV_CDR 5899 13541, 21183, 28825, 36467, 44109, 51751, 59393anti-HIV_CDR 5900 13542, 21184, 28826, 36468, 44110, 51752, 59394anti-HIV_CDR 5901 13543, 21185, 28827, 36469, 44111, 51753, 59395anti-HIV_CDR 5902 13544, 21186, 28828, 36470, 44112, 51754, 59396anti-HIV_CDR 5903 13545, 21187, 28829, 36471, 44113, 51755, 59397anti-HIV_CDR 5904 13546, 21188, 28830, 36472, 44114, 51756, 59398anti-HIV_CDR 5905 13547, 21189, 28831, 36473, 44115, 51757, 59399anti-HIV_CDR 5906 13548, 21190, 28832, 36474, 44116, 51758, 59400anti-HIV_CDR 5907 13549, 21191, 28833, 36475, 44117, 51759, 59401anti-HIV_CDR 5908 13550, 21192, 28834, 36476, 44118, 51760, 59402anti-HIV_CDR 5909 13551, 21193, 28835, 36477, 44119, 51761, 59403anti-HIV_CDR 5910 13552, 21194, 28836, 36478, 44120, 51762, 59404anti-HIV_CDR 5911 13553, 21195, 28837, 36479, 44121, 51763, 59405anti-HIV_CDR 5912 13554, 21196, 28838, 36480, 44122, 51764, 59406anti-HIV_CDR 5913 13555, 21197, 28839, 36481, 44123, 51765, 59407anti-HIV_CDR 5914 13556, 21198, 28840, 36482, 44124, 51766, 59408anti-HIV_CDR 5915 13557, 21199, 28841, 36483, 44125, 51767, 59409anti-HIV_CDR 5916 13558, 21200, 28842, 36484, 44126, 51768, 59410anti-HIV_CDR 5917 13559, 21201, 28843, 36485, 44127, 51769, 59411anti-HIV_CDR 5918 13560, 21202, 28844, 36486, 44128, 51770, 59412anti-HIV_CDR 5919 13561, 21203, 28845, 36487, 44129, 51771, 59413anti-HIV_CDR 5920 13562, 21204, 28846, 36488, 44130, 51772, 59414anti-HIV_CDR 5921 13563, 21205, 28847, 36489, 44131, 51773, 59415anti-HIV_CDR 5922 13564, 21206, 28848, 36490, 44132, 51774, 59416anti-HIV_CDR 5923 13565, 21207, 28849, 36491, 44133, 51775, 59417anti-HIV_CDR 5924 13566, 21208, 28850, 36492, 44134, 51776, 59418anti-HIV_CDR 5925 13567, 21209, 28851, 36493, 44135, 51777, 59419anti-HIV_CDR 5926 13568, 21210, 28852, 36494, 44136, 51778, 59420anti-HIV_CDR 5927 13569, 21211, 28853, 36495, 44137, 51779, 59421anti-HIV_CDR 5928 13570, 21212, 28854, 36496, 44138, 51780, 59422anti-HIV_CDR 5929 13571, 21213, 28855, 36497, 44139, 51781, 59423anti-HIV_CDR 5930 13572, 21214, 28856, 36498, 44140, 51782, 59424anti-HIV_CDR 5931 13573, 21215, 28857, 36499, 44141, 51783, 59425anti-HIV_CDR 5932 13574, 21216, 28858, 36500, 44142, 51784, 59426anti-HIV_CDR 5933 13575, 21217, 28859, 36501, 44143, 51785, 59427anti-HIV_CDR 5934 13576, 21218, 28860, 36502, 44144, 51786, 59428anti-HIV_CDR 5935 13577, 21219, 28861, 36503, 44145, 51787, 59429anti-HIV_CDR 5936 13578, 21220, 28862, 36504, 44146, 51788, 59430anti-HIV_CDR 5937 13579, 21221, 28863, 36505, 44147, 51789, 59431anti-HIV_CDR 5938 13580, 21222, 28864, 36506, 44148, 51790, 59432anti-HIV_CDR 5939 13581, 21223, 28865, 36507, 44149, 51791, 59433anti-HIV_CDR 5940 13582, 21224, 28866, 36508, 44150, 51792, 59434anti-HIV_CDR 5941 13583, 21225, 28867, 36509, 44151, 51793, 59435anti-HIV_CDR 5942 13584, 21226, 28868, 36510, 44152, 51794, 59436anti-HIV_CDR 5943 13585, 21227, 28869, 36511, 44153, 51795, 59437anti-HIV_CDR 5944 13586, 21228, 28870, 36512, 44154, 51796, 59438anti-HIV_CDR 5945 13587, 21229, 28871, 36513, 44155, 51797, 59439anti-HIV_CDR 5946 13588, 21230, 28872, 36514, 44156, 51798, 59440anti-HIV_CDR 5947 13589, 21231, 28873, 36515, 44157, 51799, 59441anti-HIV_CDR 5948 13590, 21232, 28874, 36516, 44158, 51800, 59442anti-HIV_CDR 5949 13591, 21233, 28875, 36517, 44159, 51801, 59443anti-HIV_CDR 5950 13592, 21234, 28876, 36518, 44160, 51802, 59444anti-HIV_CDR 5951 13593, 21235, 28877, 36519, 44161, 51803, 59445anti-HIV_CDR 5952 13594, 21236, 28878, 36520, 44162, 51804, 59446anti-HIV_CDR 5953 13595, 21237, 28879, 36521, 44163, 51805, 59447anti-HIV_CDR 5954 13596, 21238, 28880, 36522, 44164, 51806, 59448anti-HIV_CDR 5955 13597, 21239, 28881, 36523, 44165, 51807, 59449anti-HIV_CDR 5956 13598, 21240, 28882, 36524, 44166, 51808, 59450anti-HIV_CDR 5957 13599, 21241, 28883, 36525, 44167, 51809, 59451anti-HIV_CDR 5958 13600, 21242, 28884, 36526, 44168, 51810, 59452anti-HIV_CDR 5959 13601, 21243, 28885, 36527, 44169, 51811, 59453anti-HIV_CDR 5960 13602, 21244, 28886, 36528, 44170, 51812, 59454anti-HIV_CDR 5961 13603, 21245, 28887, 36529, 44171, 51813, 59455anti-HIV_CDR 5962 13604, 21246, 28888, 36530, 44172, 51814, 59456anti-HIV_CDR 5963 13605, 21247, 28889, 36531, 44173, 51815, 59457anti-HIV_CDR 5964 13606, 21248, 28890, 36532, 44174, 51816, 59458anti-HIV_CDR 5965 13607, 21249, 28891, 36533, 44175, 51817, 59459anti-HIV_CDR 5966 13608, 21250, 28892, 36534, 44176, 51818, 59460anti-HIV_CDR 5967 13609, 21251, 28893, 36535, 44177, 51819, 59461anti-HIV_CDR 5968 13610, 21252, 28894, 36536, 44178, 51820, 59462anti-HIV_CDR 5969 13611, 21253, 28895, 36537, 44179, 51821, 59463anti-HIV_CDR 5970 13612, 21254, 28896, 36538, 44180, 51822, 59464anti-HIV_CDR 5971 13613, 21255, 28897, 36539, 44181, 51823, 59465anti-HIV_CDR 5972 13614, 21256, 28898, 36540, 44182, 51824, 59466anti-HIV_CDR 5973 13615, 21257, 28899, 36541, 44183, 51825, 59467anti-HIV_CDR 5974 13616, 21258, 28900, 36542, 44184, 51826, 59468anti-HIV_CDR 5975 13617, 21259, 28901, 36543, 44185, 51827, 59469anti-HIV_CDR 5976 13618, 21260, 28902, 36544, 44186, 51828, 59470anti-HIV_CDR 5977 13619, 21261, 28903, 36545, 44187, 51829, 59471anti-HIV_CDR 5978 13620, 21262, 28904, 36546, 44188, 51830, 59472anti-HIV_CDR 5979 13621, 21263, 28905, 36547, 44189, 51831, 59473anti-HIV_CDR 5980 13622, 21264, 28906, 36548, 44190, 51832, 59474anti-HIV_CDR 5981 13623, 21265, 28907, 36549, 44191, 51833, 59475anti-HIV_CDR 5982 13624, 21266, 28908, 36550, 44192, 51834, 59476anti-HIV_CDR 5983 13625, 21267, 28909, 36551, 44193, 51835, 59477anti-HIV_CDR 5984 13626, 21268, 28910, 36552, 44194, 51836, 59478anti-HIV_CDR 5985 13627, 21269, 28911, 36553, 44195, 51837, 59479anti-HIV_CDR 5986 13628, 21270, 28912, 36554, 44196, 51838, 59480anti-HIV_CDR 5987 13629, 21271, 28913, 36555, 44197, 51839, 59481anti-HIV_CDR 5988 13630, 21272, 28914, 36556, 44198, 51840, 59482anti-HIV_CDR 5989 13631, 21273, 28915, 36557, 44199, 51841, 59483anti-HIV_CDR 5990 13632, 21274, 28916, 36558, 44200, 51842, 59484anti-HIV_CDR 5991 13633, 21275, 28917, 36559, 44201, 51843, 59485anti-HIV_CDR 5992 13634, 21276, 28918, 36560, 44202, 51844, 59486anti-HIV_CDR 5993 13635, 21277, 28919, 36561, 44203, 51845, 59487anti-HIV_CDR 5994 13636, 21278, 28920, 36562, 44204, 51846, 59488anti-HIV_CDR 5995 13637, 21279, 28921, 36563, 44205, 51847, 59489anti-HIV_CDR 5996 13638, 21280, 28922, 36564, 44206, 51848, 59490anti-HIV_CDR 5997 13639, 21281, 28923, 36565, 44207, 51849, 59491anti-HIV_CDR 5998 13640, 21282, 28924, 36566, 44208, 51850, 59492anti-HIV_CDR 5999 13641, 21283, 28925, 36567, 44209, 51851, 59493anti-HIV_CDR 6000 13642, 21284, 28926, 36568, 44210, 51852, 59494anti-HIV_CDR 6001 13643, 21285, 28927, 36569, 44211, 51853, 59495anti-HIV_CDR 6002 13644, 21286, 28928, 36570, 44212, 51854, 59496anti-HIV_CDR 6003 13645, 21287, 28929, 36571, 44213, 51855, 59497anti-HIV_CDR 6004 13646, 21288, 28930, 36572, 44214, 51856, 59498anti-HIV_CDR 6005 13647, 21289, 28931, 36573, 44215, 51857, 59499anti-HIV_CDR 6006 13648, 21290, 28932, 36574, 44216, 51858, 59500anti-HIV_CDR 6007 13649, 21291, 28933, 36575, 44217, 51859, 59501anti-HIV_CDR 6008 13650, 21292, 28934, 36576, 44218, 51860, 59502anti-HIV_CDR 6009 13651, 21293, 28935, 36577, 44219, 51861, 59503anti-HIV_CDR 6010 13652, 21294, 28936, 36578, 44220, 51862, 59504anti-HIV_CDR 6011 13653, 21295, 28937, 36579, 44221, 51863, 59505anti-HIV_CDR 6012 13654, 21296, 28938, 36580, 44222, 51864, 59506anti-HIV_CDR 6013 13655, 21297, 28939, 36581, 44223, 51865, 59507anti-HIV_CDR 6014 13656, 21298, 28940, 36582, 44224, 51866, 59508anti-HIV_CDR 6015 13657, 21299, 28941, 36583, 44225, 51867, 59509anti-HIV_CDR 6016 13658, 21300, 28942, 36584, 44226, 51868, 59510anti-HIV_CDR 6017 13659, 21301, 28943, 36585, 44227, 51869, 59511anti-HIV_CDR 6018 13660, 21302, 28944, 36586, 44228, 51870, 59512anti-HIV_CDR 6019 13661, 21303, 28945, 36587, 44229, 51871, 59513anti-HIV_CDR 6020 13662, 21304, 28946, 36588, 44230, 51872, 59514anti-HIV_CDR 6021 13663, 21305, 28947, 36589, 44231, 51873, 59515anti-HIV_CDR 6022 13664, 21306, 28948, 36590, 44232, 51874, 59516anti-HIV_CDR 6023 13665, 21307, 28949, 36591, 44233, 51875, 59517anti-HIV_CDR 6024 13666, 21308, 28950, 36592, 44234, 51876, 59518anti-HIV_CDR 6025 13667, 21309, 28951, 36593, 44235, 51877, 59519anti-HIV_CDR 6026 13668, 21310, 28952, 36594, 44236, 51878, 59520anti-HIV_CDR 6027 13669, 21311, 28953, 36595, 44237, 51879, 59521anti-HIV_CDR 6028 13670, 21312, 28954, 36596, 44238, 51880, 59522anti-HIV_CDR 6029 13671, 21313, 28955, 36597, 44239, 51881, 59523anti-HIV_CDR 6030 13672, 21314, 28956, 36598, 44240, 51882, 59524anti-HIV_CDR 6031 13673, 21315, 28957, 36599, 44241, 51883, 59525anti-HIV_CDR 6032 13674, 21316, 28958, 36600, 44242, 51884, 59526anti-HIV_CDR 6033 13675, 21317, 28959, 36601, 44243, 51885, 59527anti-HIV_CDR 6034 13676, 21318, 28960, 36602, 44244, 51886, 59528anti-HIV_CDR 6035 13677, 21319, 28961, 36603, 44245, 51887, 59529anti-HIV_CDR 6036 13678, 21320, 28962, 36604, 44246, 51888, 59530anti-HIV_CDR 6037 13679, 21321, 28963, 36605, 44247, 51889, 59531anti-HIV_CDR 6038 13680, 21322, 28964, 36606, 44248, 51890, 59532anti-HIV_CDR 6039 13681, 21323, 28965, 36607, 44249, 51891, 59533anti-HIV_CDR 6040 13682, 21324, 28966, 36608, 44250, 51892, 59534anti-HIV_CDR 6041 13683, 21325, 28967, 36609, 44251, 51893, 59535anti-HIV_CDR 6042 13684, 21326, 28968, 36610, 44252, 51894, 59536anti-HIV_CDR 6043 13685, 21327, 28969, 36611, 44253, 51895, 59537anti-HIV_CDR 6044 13686, 21328, 28970, 36612, 44254, 51896, 59538anti-HIV_CDR 6045 13687, 21329, 28971, 36613, 44255, 51897, 59539anti-HIV_CDR 6046 13688, 21330, 28972, 36614, 44256, 51898, 59540anti-HIV_CDR 6047 13689, 21331, 28973, 36615, 44257, 51899, 59541anti-HIV_CDR 6048 13690, 21332, 28974, 36616, 44258, 51900, 59542anti-HIV_CDR 6049 13691, 21333, 28975, 36617, 44259, 51901, 59543anti-HIV_CDR 6050 13692, 21334, 28976, 36618, 44260, 51902, 59544anti-HIV_CDR 6051 13693, 21335, 28977, 36619, 44261, 51903, 59545anti-HIV_CDR 6052 13694, 21336, 28978, 36620, 44262, 51904, 59546anti-HIV_CDR 6053 13695, 21337, 28979, 36621, 44263, 51905, 59547anti-HIV_CDR 6054 13696, 21338, 28980, 36622, 44264, 51906, 59548anti-HIV_CDR 6055 13697, 21339, 28981, 36623, 44265, 51907, 59549anti-HIV_CDR 6056 13698, 21340, 28982, 36624, 44266, 51908, 59550anti-HIV_CDR 6057 13699, 21341, 28983, 36625, 44267, 51909, 59551anti-HIV_CDR 6058 13700, 21342, 28984, 36626, 44268, 51910, 59552anti-HIV_CDR 6059 13701, 21343, 28985, 36627, 44269, 51911, 59553anti-HIV_CDR 6060 13702, 21344, 28986, 36628, 44270, 51912, 59554anti-HIV_CDR 6061 13703, 21345, 28987, 36629, 44271, 51913, 59555anti-HIV_CDR 6062 13704, 21346, 28988, 36630, 44272, 51914, 59556anti-HIV_CDR 6063 13705, 21347, 28989, 36631, 44273, 51915, 59557anti-HIV_CDR 6064 13706, 21348, 28990, 36632, 44274, 51916, 59558anti-HIV_CDR 6065 13707, 21349, 28991, 36633, 44275, 51917, 59559anti-HIV_CDR 6066 13708, 21350, 28992, 36634, 44276, 51918, 59560anti-HIV_CDR 6067 13709, 21351, 28993, 36635, 44277, 51919, 59561anti-HIV_CDR 6068 13710, 21352, 28994, 36636, 44278, 51920, 59562anti-HIV_CDR 6069 13711, 21353, 28995, 36637, 44279, 51921, 59563anti-HIV_CDR 6070 13712, 21354, 28996, 36638, 44280, 51922, 59564anti-HIV_CDR 6071 13713, 21355, 28997, 36639, 44281, 51923, 59565anti-HIV_CDR 6072 13714, 21356, 28998, 36640, 44282, 51924, 59566anti-HIV_CDR 6073 13715, 21357, 28999, 36641, 44283, 51925, 59567anti-HIV_CDR 6074 13716, 21358, 29000, 36642, 44284, 51926, 59568anti-HIV_CDR 6075 13717, 21359, 29001, 36643, 44285, 51927, 59569anti-HIV_CDR 6076 13718, 21360, 29002, 36644, 44286, 51928, 59570anti-HIV_CDR 6077 13719, 21361, 29003, 36645, 44287, 51929, 59571anti-HIV_CDR 6078 13720, 21362, 29004, 36646, 44288, 51930, 59572anti-HIV_CDR 6079 13721, 21363, 29005, 36647, 44289, 51931, 59573anti-HIV_CDR 6080 13722, 21364, 29006, 36648, 44290, 51932, 59574anti-HIV_CDR 6081 13723, 21365, 29007, 36649, 44291, 51933, 59575anti-HIV_CDR 6082 13724, 21366, 29008, 36650, 44292, 51934, 59576anti-HIV_CDR 6083 13725, 21367, 29009, 36651, 44293, 51935, 59577anti-HIV_CDR 6084 13726, 21368, 29010, 36652, 44294, 51936, 59578anti-HIV_CDR 6085 13727, 21369, 29011, 36653, 44295, 51937, 59579anti-HIV_CDR 6086 13728, 21370, 29012, 36654, 44296, 51938, 59580anti-HIV_CDR 6087 13729, 21371, 29013, 36655, 44297, 51939, 59581anti-HIV_CDR 6088 13730, 21372, 29014, 36656, 44298, 51940, 59582anti-HIV_CDR 6089 13731, 21373, 29015, 36657, 44299, 51941, 59583anti-HIV_CDR 6090 13732, 21374, 29016, 36658, 44300, 51942, 59584anti-HIV_CDR 6091 13733, 21375, 29017, 36659, 44301, 51943, 59585anti-HIV_CDR 6092 13734, 21376, 29018, 36660, 44302, 51944, 59586anti-HIV_CDR 6093 13735, 21377, 29019, 36661, 44303, 51945, 59587anti-HIV_CDR 6094 13736, 21378, 29020, 36662, 44304, 51946, 59588anti-HIV_CDR 6095 13737, 21379, 29021, 36663, 44305, 51947, 59589anti-HIV_CDR 6096 13738, 21380, 29022, 36664, 44306, 51948, 59590anti-HIV_CDR 6097 13739, 21381, 29023, 36665, 44307, 51949, 59591anti-HIV_CDR 6098 13740, 21382, 29024, 36666, 44308, 51950, 59592anti-HIV_CDR 6099 13741, 21383, 29025, 36667, 44309, 51951, 59593anti-HIV_CDR 6100 13742, 21384, 29026, 36668, 44310, 51952, 59594anti-HIV_CDR 6101 13743, 21385, 29027, 36669, 44311, 51953, 59595anti-HIV_CDR 6102 13744, 21386, 29028, 36670, 44312, 51954, 59596anti-HIV_CDR 6103 13745, 21387, 29029, 36671, 44313, 51955, 59597anti-HIV_CDR 6104 13746, 21388, 29030, 36672, 44314, 51956, 59598anti-HIV_CDR 6105 13747, 21389, 29031, 36673, 44315, 51957, 59599anti-HIV_CDR 6106 13748, 21390, 29032, 36674, 44316, 51958, 59600anti-HIV_CDR 6107 13749, 21391, 29033, 36675, 44317, 51959, 59601anti-HIV_CDR 6108 13750, 21392, 29034, 36676, 44318, 51960, 59602anti-HIV_CDR 6109 13751, 21393, 29035, 36677, 44319, 51961, 59603anti-HIV_CDR 6110 13752, 21394, 29036, 36678, 44320, 51962, 59604anti-HIV_CDR 6111 13753, 21395, 29037, 36679, 44321, 51963, 59605anti-HIV_CDR 6112 13754, 21396, 29038, 36680, 44322, 51964, 59606anti-HIV_CDR 6113 13755, 21397, 29039, 36681, 44323, 51965, 59607anti-HIV_CDR 6114 13756, 21398, 29040, 36682, 44324, 51966, 59608anti-HIV_CDR 6115 13757, 21399, 29041, 36683, 44325, 51967, 59609anti-HIV_CDR 6116 13758, 21400, 29042, 36684, 44326, 51968, 59610anti-HIV_CDR 6117 13759, 21401, 29043, 36685, 44327, 51969, 59611anti-HIV_CDR 6118 13760, 21402, 29044, 36686, 44328, 51970, 59612anti-HIV_CDR 6119 13761, 21403, 29045, 36687, 44329, 51971, 59613anti-HIV_CDR 6120 13762, 21404, 29046, 36688, 44330, 51972, 59614anti-HIV_CDR 6121 13763, 21405, 29047, 36689, 44331, 51973, 59615anti-HIV_CDR 6122 13764, 21406, 29048, 36690, 44332, 51974, 59616anti-HIV_CDR 6123 13765, 21407, 29049, 36691, 44333, 51975, 59617anti-HIV_CDR 6124 13766, 21408, 29050, 36692, 44334, 51976, 59618anti-HIV_CDR 6125 13767, 21409, 29051, 36693, 44335, 51977, 59619anti-HIV_CDR 6126 13768, 21410, 29052, 36694, 44336, 51978, 59620anti-HIV_CDR 6127 13769, 21411, 29053, 36695, 44337, 51979, 59621anti-HIV_CDR 6128 13770, 21412, 29054, 36696, 44338, 51980, 59622anti-HIV_CDR 6129 13771, 21413, 29055, 36697, 44339, 51981, 59623anti-HIV_CDR 6130 13772, 21414, 29056, 36698, 44340, 51982, 59624anti-HIV_CDR 6131 13773, 21415, 29057, 36699, 44341, 51983, 59625anti-HIV_CDR 6132 13774, 21416, 29058, 36700, 44342, 51984, 59626anti-HIV_CDR 6133 13775, 21417, 29059, 36701, 44343, 51985, 59627anti-HIV_CDR 6134 13776, 21418, 29060, 36702, 44344, 51986, 59628anti-HIV_CDR 6135 13777, 21419, 29061, 36703, 44345, 51987, 59629anti-HIV_CDR 6136 13778, 21420, 29062, 36704, 44346, 51988, 59630anti-HIV_CDR 6137 13779, 21421, 29063, 36705, 44347, 51989, 59631anti-HIV_CDR 6138 13780, 21422, 29064, 36706, 44348, 51990, 59632anti-HIV_CDR 6139 13781, 21423, 29065, 36707, 44349, 51991, 59633anti-HIV_CDR 6140 13782, 21424, 29066, 36708, 44350, 51992, 59634anti-HIV_CDR 6141 13783, 21425, 29067, 36709, 44351, 51993, 59635anti-HIV_CDR 6142 13784, 21426, 29068, 36710, 44352, 51994, 59636anti-HIV_CDR 6143 13785, 21427, 29069, 36711, 44353, 51995, 59637anti-HIV_CDR 6144 13786, 21428, 29070, 36712, 44354, 51996, 59638anti-HIV_CDR 6145 13787, 21429, 29071, 36713, 44355, 51997, 59639anti-HIV_CDR 6146 13788, 21430, 29072, 36714, 44356, 51998, 59640anti-HIV_CDR 6147 13789, 21431, 29073, 36715, 44357, 51999, 59641anti-HIV_CDR 6148 13790, 21432, 29074, 36716, 44358, 52000, 59642anti-HIV_CDR 6149 13791, 21433, 29075, 36717, 44359, 52001, 59643anti-HIV_CDR 6150 13792, 21434, 29076, 36718, 44360, 52002, 59644anti-HIV_CDR 6151 13793, 21435, 29077, 36719, 44361, 52003, 59645anti-HIV_CDR 6152 13794, 21436, 29078, 36720, 44362, 52004, 59646anti-HIV_CDR 6153 13795, 21437, 29079, 36721, 44363, 52005, 59647anti-HIV_CDR 6154 13796, 21438, 29080, 36722, 44364, 52006, 59648anti-HIV_CDR 6155 13797, 21439, 29081, 36723, 44365, 52007, 59649anti-HIV_CDR 6156 13798, 21440, 29082, 36724, 44366, 52008, 59650anti-HIV_CDR 6157 13799, 21441, 29083, 36725, 44367, 52009, 59651anti-HIV_CDR 6158 13800, 21442, 29084, 36726, 44368, 52010, 59652anti-HIV_CDR 6159 13801, 21443, 29085, 36727, 44369, 52011, 59653anti-HIV_CDR 6160 13802, 21444, 29086, 36728, 44370, 52012, 59654anti-HIV_CDR 6161 13803, 21445, 29087, 36729, 44371, 52013, 59655anti-HIV_CDR 6162 13804, 21446, 29088, 36730, 44372, 52014, 59656anti-HIV_CDR 6163 13805, 21447, 29089, 36731, 44373, 52015, 59657anti-HIV_CDR 6164 13806, 21448, 29090, 36732, 44374, 52016, 59658anti-HIV_CDR 6165 13807, 21449, 29091, 36733, 44375, 52017, 59659anti-HIV_CDR 6166 13808, 21450, 29092, 36734, 44376, 52018, 59660anti-HIV_CDR 6167 13809, 21451, 29093, 36735, 44377, 52019, 59661anti-HIV_CDR 6168 13810, 21452, 29094, 36736, 44378, 52020, 59662anti-HIV_CDR 6169 13811, 21453, 29095, 36737, 44379, 52021, 59663anti-HIV_CDR 6170 13812, 21454, 29096, 36738, 44380, 52022, 59664anti-HIV_CDR 6171 13813, 21455, 29097, 36739, 44381, 52023, 59665anti-HIV_CDR 6172 13814, 21456, 29098, 36740, 44382, 52024, 59666anti-HIV_CDR 6173 13815, 21457, 29099, 36741, 44383, 52025, 59667anti-HIV_CDR 6174 13816, 21458, 29100, 36742, 44384, 52026, 59668anti-HIV_CDR 6175 13817, 21459, 29101, 36743, 44385, 52027, 59669anti-HIV_CDR 6176 13818, 21460, 29102, 36744, 44386, 52028, 59670anti-HIV_CDR 6177 13819, 21461, 29103, 36745, 44387, 52029, 59671anti-HIV_CDR 6178 13820, 21462, 29104, 36746, 44388, 52030, 59672anti-HIV_CDR 6179 13821, 21463, 29105, 36747, 44389, 52031, 59673anti-HIV_CDR 6180 13822, 21464, 29106, 36748, 44390, 52032, 59674anti-HIV_CDR 6181 13823, 21465, 29107, 36749, 44391, 52033, 59675anti-HIV_CDR 6182 13824, 21466, 29108, 36750, 44392, 52034, 59676anti-HIV_CDR 6183 13825, 21467, 29109, 36751, 44393, 52035, 59677anti-HIV_CDR 6184 13826, 21468, 29110, 36752, 44394, 52036, 59678anti-HIV_CDR 6185 13827, 21469, 29111, 36753, 44395, 52037, 59679anti-HIV_CDR 6186 13828, 21470, 29112, 36754, 44396, 52038, 59680anti-HIV_CDR 6187 13829, 21471, 29113, 36755, 44397, 52039, 59681anti-HIV_CDR 6188 13830, 21472, 29114, 36756, 44398, 52040, 59682anti-HIV_CDR 6189 13831, 21473, 29115, 36757, 44399, 52041, 59683anti-HIV_CDR 6190 13832, 21474, 29116, 36758, 44400, 52042, 59684anti-HIV_CDR 6191 13833, 21475, 29117, 36759, 44401, 52043, 59685anti-HIV_CDR 6192 13834, 21476, 29118, 36760, 44402, 52044, 59686anti-HIV_CDR 6193 13835, 21477, 29119, 36761, 44403, 52045, 59687anti-HIV_CDR 6194 13836, 21478, 29120, 36762, 44404, 52046, 59688anti-HIV_CDR 6195 13837, 21479, 29121, 36763, 44405, 52047, 59689anti-HIV_CDR 6196 13838, 21480, 29122, 36764, 44406, 52048, 59690anti-HIV_CDR 6197 13839, 21481, 29123, 36765, 44407, 52049, 59691anti-HIV_CDR 6198 13840, 21482, 29124, 36766, 44408, 52050, 59692anti-HIV_CDR 6199 13841, 21483, 29125, 36767, 44409, 52051, 59693anti-HIV_CDR 6200 13842, 21484, 29126, 36768, 44410, 52052, 59694anti-HIV_CDR 6201 13843, 21485, 29127, 36769, 44411, 52053, 59695anti-HIV_CDR 6202 13844, 21486, 29128, 36770, 44412, 52054, 59696anti-HIV_CDR 6203 13845, 21487, 29129, 36771, 44413, 52055, 59697anti-HIV_CDR 6204 13846, 21488, 29130, 36772, 44414, 52056, 59698anti-HIV_CDR 6205 13847, 21489, 29131, 36773, 44415, 52057, 59699anti-HIV_CDR 6206 13848, 21490, 29132, 36774, 44416, 52058, 59700anti-HIV_CDR 6207 13849, 21491, 29133, 36775, 44417, 52059, 59701anti-HIV_CDR 6208 13850, 21492, 29134, 36776, 44418, 52060, 59702anti-HIV_CDR 6209 13851, 21493, 29135, 36777, 44419, 52061, 59703anti-HIV_CDR 6210 13852, 21494, 29136, 36778, 44420, 52062, 59704anti-HIV_CDR 6211 13853, 21495, 29137, 36779, 44421, 52063, 59705anti-HIV_CDR 6212 13854, 21496, 29138, 36780, 44422, 52064, 59706anti-HIV_CDR 6213 13855, 21497, 29139, 36781, 44423, 52065, 59707anti-HIV_CDR 6214 13856, 21498, 29140, 36782, 44424, 52066, 59708anti-HIV_CDR 6215 13857, 21499, 29141, 36783, 44425, 52067, 59709anti-HIV_CDR 6216 13858, 21500, 29142, 36784, 44426, 52068, 59710anti-HIV_CDR 6217 13859, 21501, 29143, 36785, 44427, 52069, 59711anti-HIV_CDR 6218 13860, 21502, 29144, 36786, 44428, 52070, 59712anti-HIV_CDR 6219 13861, 21503, 29145, 36787, 44429, 52071, 59713anti-HIV_CDR 6220 13862, 21504, 29146, 36788, 44430, 52072, 59714anti-HIV_CDR 6221 13863, 21505, 29147, 36789, 44431, 52073, 59715anti-HIV_CDR 6222 13864, 21506, 29148, 36790, 44432, 52074, 59716anti-HIV_CDR 6223 13865, 21507, 29149, 36791, 44433, 52075, 59717anti-HIV_CDR 6224 13866, 21508, 29150, 36792, 44434, 52076, 59718anti-HIV_CDR 6225 13867, 21509, 29151, 36793, 44435, 52077, 59719anti-HIV_CDR 6226 13868, 21510, 29152, 36794, 44436, 52078, 59720anti-HIV_CDR 6227 13869, 21511, 29153, 36795, 44437, 52079, 59721anti-HIV_CDR 6228 13870, 21512, 29154, 36796, 44438, 52080, 59722anti-HIV_CDR 6229 13871, 21513, 29155, 36797, 44439, 52081, 59723anti-HIV_CDR 6230 13872, 21514, 29156, 36798, 44440, 52082, 59724anti-HIV_CDR 6231 13873, 21515, 29157, 36799, 44441, 52083, 59725anti-HIV_CDR 6232 13874, 21516, 29158, 36800, 44442, 52084, 59726anti-HIV_CDR 6233 13875, 21517, 29159, 36801, 44443, 52085, 59727anti-HIV_CDR 6234 13876, 21518, 29160, 36802, 44444, 52086, 59728anti-HIV_CDR 6235 13877, 21519, 29161, 36803, 44445, 52087, 59729anti-HIV_CDR 6236 13878, 21520, 29162, 36804, 44446, 52088, 59730anti-HIV_CDR 6237 13879, 21521, 29163, 36805, 44447, 52089, 59731anti-HIV_CDR 6238 13880, 21522, 29164, 36806, 44448, 52090, 59732anti-HIV_CDR 6239 13881, 21523, 29165, 36807, 44449, 52091, 59733anti-HIV_CDR 6240 13882, 21524, 29166, 36808, 44450, 52092, 59734anti-HIV_CDR 6241 13883, 21525, 29167, 36809, 44451, 52093, 59735anti-HIV_CDR 6242 13884, 21526, 29168, 36810, 44452, 52094, 59736anti-HIV_CDR 6243 13885, 21527, 29169, 36811, 44453, 52095, 59737anti-HIV_CDR 6244 13886, 21528, 29170, 36812, 44454, 52096, 59738anti-HIV_CDR 6245 13887, 21529, 29171, 36813, 44455, 52097, 59739anti-HIV_CDR 6246 13888, 21530, 29172, 36814, 44456, 52098, 59740anti-HIV_CDR 6247 13889, 21531, 29173, 36815, 44457, 52099, 59741anti-HIV_CDR 6248 13890, 21532, 29174, 36816, 44458, 52100, 59742anti-HIV_CDR 6249 13891, 21533, 29175, 36817, 44459, 52101, 59743anti-HIV_CDR 6250 13892, 21534, 29176, 36818, 44460, 52102, 59744anti-HIV_CDR 6251 13893, 21535, 29177, 36819, 44461, 52103, 59745anti-HIV_CDR 6252 13894, 21536, 29178, 36820, 44462, 52104, 59746anti-HIV_CDR 6253 13895, 21537, 29179, 36821, 44463, 52105, 59747anti-HIV_CDR 6254 13896, 21538, 29180, 36822, 44464, 52106, 59748anti-HIV_CDR 6255 13897, 21539, 29181, 36823, 44465, 52107, 59749anti-HIV_CDR 6256 13898, 21540, 29182, 36824, 44466, 52108, 59750anti-HIV_CDR 6257 13899, 21541, 29183, 36825, 44467, 52109, 59751anti-HIV_CDR 6258 13900, 21542, 29184, 36826, 44468, 52110, 59752anti-HIV_CDR 6259 13901, 21543, 29185, 36827, 44469, 52111, 59753anti-HIV_CDR 6260 13902, 21544, 29186, 36828, 44470, 52112, 59754anti-HIV_CDR 6261 13903, 21545, 29187, 36829, 44471, 52113, 59755anti-HIV_CDR 6262 13904, 21546, 29188, 36830, 44472, 52114, 59756anti-HIV_CDR 6263 13905, 21547, 29189, 36831, 44473, 52115, 59757anti-HIV_CDR 6264 13906, 21548, 29190, 36832, 44474, 52116, 59758anti-HIV_CDR 6265 13907, 21549, 29191, 36833, 44475, 52117, 59759anti-HIV_CDR 6266 13908, 21550, 29192, 36834, 44476, 52118, 59760anti-HIV_CDR 6267 13909, 21551, 29193, 36835, 44477, 52119, 59761anti-HIV_CDR 6268 13910, 21552, 29194, 36836, 44478, 52120, 59762anti-HIV_CDR 6269 13911, 21553, 29195, 36837, 44479, 52121, 59763anti-HIV_CDR 6270 13912, 21554, 29196, 36838, 44480, 52122, 59764anti-HIV_CDR 6271 13913, 21555, 29197, 36839, 44481, 52123, 59765anti-HIV_CDR 6272 13914, 21556, 29198, 36840, 44482, 52124, 59766anti-HIV_CDR 6273 13915, 21557, 29199, 36841, 44483, 52125, 59767anti-HIV_CDR 6274 13916, 21558, 29200, 36842, 44484, 52126, 59768anti-HIV_CDR 6275 13917, 21559, 29201, 36843, 44485, 52127, 59769anti-HIV_CDR 6276 13918, 21560, 29202, 36844, 44486, 52128, 59770anti-HIV_CDR 6277 13919, 21561, 29203, 36845, 44487, 52129, 59771anti-HIV_CDR 6278 13920, 21562, 29204, 36846, 44488, 52130, 59772anti-HIV_CDR 6279 13921, 21563, 29205, 36847, 44489, 52131, 59773anti-HIV_CDR 6280 13922, 21564, 29206, 36848, 44490, 52132, 59774anti-HIV_CDR 6281 13923, 21565, 29207, 36849, 44491, 52133, 59775anti-HIV_CDR 6282 13924, 21566, 29208, 36850, 44492, 52134, 59776anti-HIV_CDR 6283 13925, 21567, 29209, 36851, 44493, 52135, 59777anti-HIV_CDR 6284 13926, 21568, 29210, 36852, 44494, 52136, 59778anti-HIV_CDR 6285 13927, 21569, 29211, 36853, 44495, 52137, 59779anti-HIV_CDR 6286 13928, 21570, 29212, 36854, 44496, 52138, 59780anti-HIV_CDR 6287 13929, 21571, 29213, 36855, 44497, 52139, 59781anti-HIV_CDR 6288 13930, 21572, 29214, 36856, 44498, 52140, 59782anti-HIV_CDR 6289 13931, 21573, 29215, 36857, 44499, 52141, 59783anti-HIV_CDR 6290 13932, 21574, 29216, 36858, 44500, 52142, 59784anti-HIV_CDR 6291 13933, 21575, 29217, 36859, 44501, 52143, 59785anti-HIV_CDR 6292 13934, 21576, 29218, 36860, 44502, 52144, 59786anti-HIV_CDR 6293 13935, 21577, 29219, 36861, 44503, 52145, 59787anti-HIV_CDR 6294 13936, 21578, 29220, 36862, 44504, 52146, 59788anti-HIV_CDR 6295 13937, 21579, 29221, 36863, 44505, 52147, 59789anti-HIV_CDR 6296 13938, 21580, 29222, 36864, 44506, 52148, 59790anti-HIV_CDR 6297 13939, 21581, 29223, 36865, 44507, 52149, 59791anti-HIV_CDR 6298 13940, 21582, 29224, 36866, 44508, 52150, 59792anti-HIV_CDR 6299 13941, 21583, 29225, 36867, 44509, 52151, 59793anti-HIV_CDR 6300 13942, 21584, 29226, 36868, 44510, 52152, 59794anti-HIV_CDR 6301 13943, 21585, 29227, 36869, 44511, 52153, 59795anti-HIV_CDR 6302 13944, 21586, 29228, 36870, 44512, 52154, 59796anti-HIV_CDR 6303 13945, 21587, 29229, 36871, 44513, 52155, 59797anti-HIV_CDR 6304 13946, 21588, 29230, 36872, 44514, 52156, 59798anti-HIV_CDR 6305 13947, 21589, 29231, 36873, 44515, 52157, 59799anti-HIV_CDR 6306 13948, 21590, 29232, 36874, 44516, 52158, 59800anti-HIV_CDR 6307 13949, 21591, 29233, 36875, 44517, 52159, 59801anti-HIV_CDR 6308 13950, 21592, 29234, 36876, 44518, 52160, 59802anti-HIV_CDR 6309 13951, 21593, 29235, 36877, 44519, 52161, 59803anti-HIV_CDR 6310 13952, 21594, 29236, 36878, 44520, 52162, 59804anti-HIV_CDR 6311 13953, 21595, 29237, 36879, 44521, 52163, 59805anti-HIV_CDR 6312 13954, 21596, 29238, 36880, 44522, 52164, 59806anti-HIV_CDR 6313 13955, 21597, 29239, 36881, 44523, 52165, 59807anti-HIV_CDR 6314 13956, 21598, 29240, 36882, 44524, 52166, 59808anti-HIV_CDR 6315 13957, 21599, 29241, 36883, 44525, 52167, 59809anti-HIV_CDR 6316 13958, 21600, 29242, 36884, 44526, 52168, 59810anti-HIV_CDR 6317 13959, 21601, 29243, 36885, 44527, 52169, 59811anti-HIV_CDR 6318 13960, 21602, 29244, 36886, 44528, 52170, 59812anti-HIV_CDR 6319 13961, 21603, 29245, 36887, 44529, 52171, 59813anti-HIV_CDR 6320 13962, 21604, 29246, 36888, 44530, 52172, 59814anti-HIV_CDR 6321 13963, 21605, 29247, 36889, 44531, 52173, 59815anti-HIV_CDR 6322 13964, 21606, 29248, 36890, 44532, 52174, 59816anti-HIV_CDR 6323 13965, 21607, 29249, 36891, 44533, 52175, 59817anti-HIV_CDR 6324 13966, 21608, 29250, 36892, 44534, 52176, 59818anti-HIV_CDR 6325 13967, 21609, 29251, 36893, 44535, 52177, 59819anti-HIV_CDR 6326 13968, 21610, 29252, 36894, 44536, 52178, 59820anti-HIV_CDR 6327 13969, 21611, 29253, 36895, 44537, 52179, 59821anti-HIV_CDR 6328 13970, 21612, 29254, 36896, 44538, 52180, 59822anti-HIV_CDR 6329 13971, 21613, 29255, 36897, 44539, 52181, 59823anti-HIV_CDR 6330 13972, 21614, 29256, 36898, 44540, 52182, 59824anti-HIV_CDR 6331 13973, 21615, 29257, 36899, 44541, 52183, 59825anti-HIV_CDR 6332 13974, 21616, 29258, 36900, 44542, 52184, 59826anti-HIV_CDR 6333 13975, 21617, 29259, 36901, 44543, 52185, 59827anti-HIV_CDR 6334 13976, 21618, 29260, 36902, 44544, 52186, 59828anti-HIV_CDR 6335 13977, 21619, 29261, 36903, 44545, 52187, 59829anti-HIV_CDR 6336 13978, 21620, 29262, 36904, 44546, 52188, 59830anti-HIV_CDR 6337 13979, 21621, 29263, 36905, 44547, 52189, 59831anti-HIV_CDR 6338 13980, 21622, 29264, 36906, 44548, 52190, 59832anti-HIV_CDR 6339 13981, 21623, 29265, 36907, 44549, 52191, 59833anti-HIV_CDR 6340 13982, 21624, 29266, 36908, 44550, 52192, 59834anti-HIV_CDR 6341 13983, 21625, 29267, 36909, 44551, 52193, 59835anti-HIV_CDR 6342 13984, 21626, 29268, 36910, 44552, 52194, 59836anti-HIV_CDR 6343 13985, 21627, 29269, 36911, 44553, 52195, 59837anti-HIV_CDR 6344 13986, 21628, 29270, 36912, 44554, 52196, 59838anti-HIV_CDR 6345 13987, 21629, 29271, 36913, 44555, 52197, 59839anti-HIV_CDR 6346 13988, 21630, 29272, 36914, 44556, 52198, 59840anti-HIV_CDR 6347 13989, 21631, 29273, 36915, 44557, 52199, 59841anti-HIV_CDR 6348 13990, 21632, 29274, 36916, 44558, 52200, 59842anti-HIV_CDR 6349 13991, 21633, 29275, 36917, 44559, 52201, 59843anti-HIV_CDR 6350 13992, 21634, 29276, 36918, 44560, 52202, 59844anti-HIV_CDR 6351 13993, 21635, 29277, 36919, 44561, 52203, 59845anti-HIV_CDR 6352 13994, 21636, 29278, 36920, 44562, 52204, 59846anti-HIV_CDR 6353 13995, 21637, 29279, 36921, 44563, 52205, 59847anti-HIV_CDR 6354 13996, 21638, 29280, 36922, 44564, 52206, 59848anti-HIV_CDR 6355 13997, 21639, 29281, 36923, 44565, 52207, 59849anti-HIV_CDR 6356 13998, 21640, 29282, 36924, 44566, 52208, 59850anti-HIV_CDR 6357 13999, 21641, 29283, 36925, 44567, 52209, 59851anti-HIV_CDR 6358 14000, 21642, 29284, 36926, 44568, 52210, 59852anti-HIV_CDR 6359 14001, 21643, 29285, 36927, 44569, 52211, 59853anti-HIV_CDR 6360 14002, 21644, 29286, 36928, 44570, 52212, 59854anti-HIV_CDR 6361 14003, 21645, 29287, 36929, 44571, 52213, 59855anti-HIV_CDR 6362 14004, 21646, 29288, 36930, 44572, 52214, 59856anti-HIV_CDR 6363 14005, 21647, 29289, 36931, 44573, 52215, 59857anti-HIV_CDR 6364 14006, 21648, 29290, 36932, 44574, 52216, 59858anti-HIV_CDR 6365 14007, 21649, 29291, 36933, 44575, 52217, 59859anti-HIV_CDR 6366 14008, 21650, 29292, 36934, 44576, 52218, 59860anti-HIV_CDR 6367 14009, 21651, 29293, 36935, 44577, 52219, 59861anti-HIV_CDR 6368 14010, 21652, 29294, 36936, 44578, 52220, 59862anti-HIV_CDR 6369 14011, 21653, 29295, 36937, 44579, 52221, 59863anti-HIV_CDR 6370 14012, 21654, 29296, 36938, 44580, 52222, 59864anti-HIV_CDR 6371 14013, 21655, 29297, 36939, 44581, 52223, 59865anti-HIV_CDR 6372 14014, 21656, 29298, 36940, 44582, 52224, 59866anti-HIV_CDR 6373 14015, 21657, 29299, 36941, 44583, 52225, 59867anti-HIV_CDR 6374 14016, 21658, 29300, 36942, 44584, 52226, 59868anti-HIV_CDR 6375 14017, 21659, 29301, 36943, 44585, 52227, 59869anti-HIV_CDR 6376 14018, 21660, 29302, 36944, 44586, 52228, 59870anti-HIV_CDR 6377 14019, 21661, 29303, 36945, 44587, 52229, 59871anti-HIV_CDR 6378 14020, 21662, 29304, 36946, 44588, 52230, 59872anti-HIV_CDR 6379 14021, 21663, 29305, 36947, 44589, 52231, 59873anti-HIV_CDR 6380 14022, 21664, 29306, 36948, 44590, 52232, 59874anti-HIV_CDR 6381 14023, 21665, 29307, 36949, 44591, 52233, 59875anti-HIV_CDR 6382 14024, 21666, 29308, 36950, 44592, 52234, 59876anti-HIV_CDR 6383 14025, 21667, 29309, 36951, 44593, 52235, 59877anti-HIV_CDR 6384 14026, 21668, 29310, 36952, 44594, 52236, 59878anti-HIV_CDR 6385 14027, 21669, 29311, 36953, 44595, 52237, 59879anti-HIV_CDR 6386 14028, 21670, 29312, 36954, 44596, 52238, 59880anti-HIV_CDR 6387 14029, 21671, 29313, 36955, 44597, 52239, 59881anti-HIV_CDR 6388 14030, 21672, 29314, 36956, 44598, 52240, 59882anti-HIV_CDR 6389 14031, 21673, 29315, 36957, 44599, 52241, 59883anti-HIV_CDR 6390 14032, 21674, 29316, 36958, 44600, 52242, 59884anti-HIV_CDR 6391 14033, 21675, 29317, 36959, 44601, 52243, 59885anti-HIV_CDR 6392 14034, 21676, 29318, 36960, 44602, 52244, 59886anti-HIV_CDR 6393 14035, 21677, 29319, 36961, 44603, 52245, 59887anti-HIV_CDR 6394 14036, 21678, 29320, 36962, 44604, 52246, 59888anti-HIV_CDR 6395 14037, 21679, 29321, 36963, 44605, 52247, 59889anti-HIV_CDR 6396 14038, 21680, 29322, 36964, 44606, 52248, 59890anti-HIV_CDR 6397 14039, 21681, 29323, 36965, 44607, 52249, 59891anti-HIV_CDR 6398 14040, 21682, 29324, 36966, 44608, 52250, 59892anti-HIV_CDR 6399 14041, 21683, 29325, 36967, 44609, 52251, 59893anti-HIV_CDR 6400 14042, 21684, 29326, 36968, 44610, 52252, 59894anti-HIV_CDR 6401 14043, 21685, 29327, 36969, 44611, 52253, 59895anti-HIV_CDR 6402 14044, 21686, 29328, 36970, 44612, 52254, 59896anti-HIV_CDR 6403 14045, 21687, 29329, 36971, 44613, 52255, 59897anti-HIV_CDR 6404 14046, 21688, 29330, 36972, 44614, 52256, 59898anti-HIV_CDR 6405 14047, 21689, 29331, 36973, 44615, 52257, 59899anti-HIV_CDR 6406 14048, 21690, 29332, 36974, 44616, 52258, 59900anti-HIV_CDR 6407 14049, 21691, 29333, 36975, 44617, 52259, 59901anti-HIV_CDR 6408 14050, 21692, 29334, 36976, 44618, 52260, 59902anti-HIV_CDR 6409 14051, 21693, 29335, 36977, 44619, 52261, 59903anti-HIV_CDR 6410 14052, 21694, 29336, 36978, 44620, 52262, 59904anti-HIV_CDR 6411 14053, 21695, 29337, 36979, 44621, 52263, 59905anti-HIV_CDR 6412 14054, 21696, 29338, 36980, 44622, 52264, 59906anti-HIV_CDR 6413 14055, 21697, 29339, 36981, 44623, 52265, 59907anti-HIV_CDR 6414 14056, 21698, 29340, 36982, 44624, 52266, 59908anti-HIV_CDR 6415 14057, 21699, 29341, 36983, 44625, 52267, 59909anti-HIV_CDR 6416 14058, 21700, 29342, 36984, 44626, 52268, 59910anti-HIV_CDR 6417 14059, 21701, 29343, 36985, 44627, 52269, 59911anti-HIV_CDR 6418 14060, 21702, 29344, 36986, 44628, 52270, 59912anti-HIV_CDR 6419 14061, 21703, 29345, 36987, 44629, 52271, 59913anti-HIV_CDR 6420 14062, 21704, 29346, 36988, 44630, 52272, 59914anti-HIV_CDR 6421 14063, 21705, 29347, 36989, 44631, 52273, 59915anti-HIV_CDR 6422 14064, 21706, 29348, 36990, 44632, 52274, 59916anti-HIV_CDR 6423 14065, 21707, 29349, 36991, 44633, 52275, 59917anti-HIV_CDR 6424 14066, 21708, 29350, 36992, 44634, 52276, 59918anti-HIV_CDR 6425 14067, 21709, 29351, 36993, 44635, 52277, 59919anti-HIV_CDR 6426 14068, 21710, 29352, 36994, 44636, 52278, 59920anti-HIV_CDR 6427 14069, 21711, 29353, 36995, 44637, 52279, 59921anti-HIV_CDR 6428 14070, 21712, 29354, 36996, 44638, 52280, 59922anti-HIV_CDR 6429 14071, 21713, 29355, 36997, 44639, 52281, 59923anti-HIV_CDR 6430 14072, 21714, 29356, 36998, 44640, 52282, 59924anti-HIV_CDR 6431 14073, 21715, 29357, 36999, 44641, 52283, 59925anti-HIV_CDR 6432 14074, 21716, 29358, 37000, 44642, 52284, 59926anti-HIV_CDR 6433 14075, 21717, 29359, 37001, 44643, 52285, 59927anti-HIV_CDR 6434 14076, 21718, 29360, 37002, 44644, 52286, 59928anti-HIV_CDR 6435 14077, 21719, 29361, 37003, 44645, 52287, 59929anti-HIV_CDR 6436 14078, 21720, 29362, 37004, 44646, 52288, 59930anti-HIV_CDR 6437 14079, 21721, 29363, 37005, 44647, 52289, 59931anti-HIV_CDR 6438 14080, 21722, 29364, 37006, 44648, 52290, 59932anti-HIV_CDR 6439 14081, 21723, 29365, 37007, 44649, 52291, 59933anti-HIV_CDR 6440 14082, 21724, 29366, 37008, 44650, 52292, 59934anti-HIV_CDR 6441 14083, 21725, 29367, 37009, 44651, 52293, 59935anti-HIV_CDR 6442 14084, 21726, 29368, 37010, 44652, 52294, 59936anti-HIV_CDR 6443 14085, 21727, 29369, 37011, 44653, 52295, 59937anti-HIV_CDR 6444 14086, 21728, 29370, 37012, 44654, 52296, 59938anti-HIV_CDR 6445 14087, 21729, 29371, 37013, 44655, 52297, 59939anti-HIV_CDR 6446 14088, 21730, 29372, 37014, 44656, 52298, 59940anti-HIV_CDR 6447 14089, 21731, 29373, 37015, 44657, 52299, 59941anti-HIV_CDR 6448 14090, 21732, 29374, 37016, 44658, 52300, 59942anti-HIV_CDR 6449 14091, 21733, 29375, 37017, 44659, 52301, 59943anti-HIV_CDR 6450 14092, 21734, 29376, 37018, 44660, 52302, 59944anti-HIV_CDR 6451 14093, 21735, 29377, 37019, 44661, 52303, 59945anti-HIV_CDR 6452 14094, 21736, 29378, 37020, 44662, 52304, 59946anti-HIV_CDR 6453 14095, 21737, 29379, 37021, 44663, 52305, 59947anti-HIV_CDR 6454 14096, 21738, 29380, 37022, 44664, 52306, 59948anti-HIV_CDR 6455 14097, 21739, 29381, 37023, 44665, 52307, 59949anti-HIV_CDR 6456 14098, 21740, 29382, 37024, 44666, 52308, 59950anti-HIV_CDR 6457 14099, 21741, 29383, 37025, 44667, 52309, 59951anti-HIV_CDR 6458 14100, 21742, 29384, 37026, 44668, 52310, 59952anti-HIV_CDR 6459 14101, 21743, 29385, 37027, 44669, 52311, 59953anti-HIV_CDR 6460 14102, 21744, 29386, 37028, 44670, 52312, 59954anti-HIV_CDR 6461 14103, 21745, 29387, 37029, 44671, 52313, 59955anti-HIV_CDR 6462 14104, 21746, 29388, 37030, 44672, 52314, 59956anti-HIV_CDR 6463 14105, 21747, 29389, 37031, 44673, 52315, 59957anti-HIV_CDR 6464 14106, 21748, 29390, 37032, 44674, 52316, 59958anti-HIV_CDR 6465 14107, 21749, 29391, 37033, 44675, 52317, 59959anti-HIV_CDR 6466 14108, 21750, 29392, 37034, 44676, 52318, 59960anti-HIV_CDR 6467 14109, 21751, 29393, 37035, 44677, 52319, 59961anti-HIV_CDR 6468 14110, 21752, 29394, 37036, 44678, 52320, 59962anti-HIV_CDR 6469 14111, 21753, 29395, 37037, 44679, 52321, 59963anti-HIV_CDR 6470 14112, 21754, 29396, 37038, 44680, 52322, 59964anti-HIV_CDR 6471 14113, 21755, 29397, 37039, 44681, 52323, 59965anti-HIV_CDR 6472 14114, 21756, 29398, 37040, 44682, 52324, 59966anti-HIV_CDR 6473 14115, 21757, 29399, 37041, 44683, 52325, 59967anti-HIV_CDR 6474 14116, 21758, 29400, 37042, 44684, 52326, 59968anti-HIV_CDR 6475 14117, 21759, 29401, 37043, 44685, 52327, 59969anti-HIV_CDR 6476 14118, 21760, 29402, 37044, 44686, 52328, 59970anti-HIV_CDR 6477 14119, 21761, 29403, 37045, 44687, 52329, 59971anti-influenza_CDR 6478 14120, 21762, 29404, 37046, 44688, 52330, 59972anti-influenza_CDR 6479 14121, 21763, 29405, 37047, 44689, 52331, 59973anti-influenza_CDR 6480 14122, 21764, 29406, 37048, 44690, 52332, 59974anti-influenza_CDR 6481 14123, 21765, 29407, 37049, 44691, 52333, 59975anti-influenza_CDR 6482 14124, 21766, 29408, 37050, 44692, 52334, 59976anti-influenza_CDR 6483 14125, 21767, 29409, 37051, 44693, 52335, 59977anti-influenza_CDR 6484 14126, 21768, 29410, 37052, 44694, 52336, 59978anti-influenza_CDR 6485 14127, 21769, 29411, 37053, 44695, 52337, 59979anti-influenza_CDR 6486 14128, 21770, 29412, 37054, 44696, 52338, 59980anti-influenza_CDR 6487 14129, 21771, 29413, 37055, 44697, 52339, 59981anti-influenza_CDR 6488 14130, 21772, 29414, 37056, 44698, 52340, 59982anti-influenza_CDR 6489 14131, 21773, 29415, 37057, 44699, 52341, 59983anti-influenza_CDR 6490 14132, 21774, 29416, 37058, 44700, 52342, 59984anti-influenza_CDR 6491 14133, 21775, 29417, 37059, 44701, 52343, 59985anti-influenza_CDR 6492 14134, 21776, 29418, 37060, 44702, 52344, 59986anti-influenza_CDR 6493 14135, 21777, 29419, 37061, 44703, 52345, 59987anti-influenza_CDR 6494 14136, 21778, 29420, 37062, 44704, 52346, 59988anti-influenza_CDR 6495 14137, 21779, 29421, 37063, 44705, 52347, 59989anti-influenza_CDR 6496 14138, 21780, 29422, 37064, 44706, 52348, 59990anti-influenza_CDR 6497 14139, 21781, 29423, 37065, 44707, 52349, 59991anti-influenza_CDR 6498 14140, 21782, 29424, 37066, 44708, 52350, 59992anti-influenza_CDR 6499 14141, 21783, 29425, 37067, 44709, 52351, 59993anti-influenza_CDR 6500 14142, 21784, 29426, 37068, 44710, 52352, 59994anti-influenza_CDR 6501 14143, 21785, 29427, 37069, 44711, 52353, 59995anti-influenza_CDR 6502 14144, 21786, 29428, 37070, 44712, 52354, 59996anti-influenza_CDR 6503 14145, 21787, 29429, 37071, 44713, 52355, 59997anti-influenza_CDR 6504 14146, 21788, 29430, 37072, 44714, 52356, 59998anti-influenza_CDR 6505 14147, 21789, 29431, 37073, 44715, 52357, 59999anti-influenza_CDR 6506 14148, 21790, 29432, 37074, 44716, 52358, 60000anti-influenza_CDR 6507 14149, 21791, 29433, 37075, 44717, 52359, 60001anti-influenza_CDR 6508 14150, 21792, 29434, 37076, 44718, 52360, 60002anti-influenza_CDR 6509 14151, 21793, 29435, 37077, 44719, 52361, 60003anti-influenza_CDR 6510 14152, 21794, 29436, 37078, 44720, 52362, 60004anti-influenza_CDR 6511 14153, 21795, 29437, 37079, 44721, 52363, 60005anti-influenza_CDR 6512 14154, 21796, 29438, 37080, 44722, 52364, 60006anti-influenza_CDR 6513 14155, 21797, 29439, 37081, 44723, 52365, 60007anti-influenza_CDR 6514 14156, 21798, 29440, 37082, 44724, 52366, 60008anti-influenza_CDR 6515 14157, 21799, 29441, 37083, 44725, 52367, 60009anti-influenza_CDR 6516 14158, 21800, 29442, 37084, 44726, 52368, 60010anti-influenza_CDR 6517 14159, 21801, 29443, 37085, 44727, 52369, 60011anti-influenza_CDR 6518 14160, 21802, 29444, 37086, 44728, 52370, 60012anti-influenza_CDR 6519 14161, 21803, 29445, 37087, 44729, 52371, 60013anti-influenza_CDR 6520 14162, 21804, 29446, 37088, 44730, 52372, 60014anti-influenza_CDR 6521 14163, 21805, 29447, 37089, 44731, 52373, 60015anti-influenza_CDR 6522 14164, 21806, 29448, 37090, 44732, 52374, 60016anti-influenza_CDR 6523 14165, 21807, 29449, 37091, 44733, 52375, 60017anti-influenza_CDR 6524 14166, 21808, 29450, 37092, 44734, 52376, 60018anti-influenza_CDR 6525 14167, 21809, 29451, 37093, 44735, 52377, 60019anti-influenza_CDR 6526 14168, 21810, 29452, 37094, 44736, 52378, 60020anti-influenza_CDR 6527 14169, 21811, 29453, 37095, 44737, 52379, 60021anti-influenza_CDR 6528 14170, 21812, 29454, 37096, 44738, 52380, 60022anti-influenza_CDR 6529 14171, 21813, 29455, 37097, 44739, 52381, 60023anti-influenza_CDR 6530 14172, 21814, 29456, 37098, 44740, 52382, 60024anti-influenza_CDR 6531 14173, 21815, 29457, 37099, 44741, 52383, 60025anti-influenza_CDR 6532 14174, 21816, 29458, 37100, 44742, 52384, 60026anti-influenza_CDR 6533 14175, 21817, 29459, 37101, 44743, 52385, 60027anti-influenza_CDR 6534 14176, 21818, 29460, 37102, 44744, 52386, 60028anti-influenza_CDR 6535 14177, 21819, 29461, 37103, 44745, 52387, 60029anti-influenza_CDR 6536 14178, 21820, 29462, 37104, 44746, 52388, 60030anti-influenza_CDR 6537 14179, 21821, 29463, 37105, 44747, 52389, 60031anti-influenza_CDR 6538 14180, 21822, 29464, 37106, 44748, 52390, 60032anti-influenza_CDR 6539 14181, 21823, 29465, 37107, 44749, 52391, 60033anti-influenza_CDR 6540 14182, 21824, 29466, 37108, 44750, 52392, 60034anti-influenza_CDR 6541 14183, 21825, 29467, 37109, 44751, 52393, 60035anti-influenza_CDR 6542 14184, 21826, 29468, 37110, 44752, 52394, 60036anti-influenza_CDR 6543 14185, 21827, 29469, 37111, 44753, 52395, 60037anti-influenza_CDR 6544 14186, 21828, 29470, 37112, 44754, 52396, 60038anti-influenza_CDR 6545 14187, 21829, 29471, 37113, 44755, 52397, 60039anti-influenza_CDR 6546 14188, 21830, 29472, 37114, 44756, 52398, 60040anti-influenza_CDR 6547 14189, 21831, 29473, 37115, 44757, 52399, 60041anti-influenza_CDR 6548 14190, 21832, 29474, 37116, 44758, 52400, 60042anti-influenza_CDR 6549 14191, 21833, 29475, 37117, 44759, 52401, 60043anti-influenza_CDR 6550 14192, 21834, 29476, 37118, 44760, 52402, 60044anti-influenza_CDR 6551 14193, 21835, 29477, 37119, 44761, 52403, 60045anti-influenza_CDR 6552 14194, 21836, 29478, 37120, 44762, 52404, 60046anti-influenza_CDR 6553 14195, 21837, 29479, 37121, 44763, 52405, 60047anti-influenza_CDR 6554 14196, 21838, 29480, 37122, 44764, 52406, 60048anti-influenza_CDR 6555 14197, 21839, 29481, 37123, 44765, 52407, 60049anti-influenza_CDR 6556 14198, 21840, 29482, 37124, 44766, 52408, 60050anti-influenza_CDR 6557 14199, 21841, 29483, 37125, 44767, 52409, 60051anti-influenza_CDR 6558 14200, 21842, 29484, 37126, 44768, 52410, 60052anti-influenza_CDR 6559 14201, 21843, 29485, 37127, 44769, 52411, 60053anti-influenza_CDR 6560 14202, 21844, 29486, 37128, 44770, 52412, 60054anti-influenza_CDR 6561 14203, 21845, 29487, 37129, 44771, 52413, 60055anti-influenza_CDR 6562 14204, 21846, 29488, 37130, 44772, 52414, 60056anti-influenza_CDR 6563 14205, 21847, 29489, 37131, 44773, 52415, 60057anti-influenza_CDR 6564 14206, 21848, 29490, 37132, 44774, 52416, 60058anti-influenza_CDR 6565 14207, 21849, 29491, 37133, 44775, 52417, 60059anti-influenza_CDR 6566 14208, 21850, 29492, 37134, 44776, 52418, 60060anti-influenza_CDR 6567 14209, 21851, 29493, 37135, 44777, 52419, 60061anti-influenza_CDR 6568 14210, 21852, 29494, 37136, 44778, 52420, 60062anti-influenza_CDR 6569 14211, 21853, 29495, 37137, 44779, 52421, 60063anti-influenza_CDR 6570 14212, 21854, 29496, 37138, 44780, 52422, 60064anti-influenza_CDR 6571 14213, 21855, 29497, 37139, 44781, 52423, 60065anti-influenza_CDR 6572 14214, 21856, 29498, 37140, 44782, 52424, 60066anti-influenza_CDR 6573 14215, 21857, 29499, 37141, 44783, 52425, 60067anti-influenza_CDR 6574 14216, 21858, 29500, 37142, 44784, 52426, 60068anti-influenza_CDR 6575 14217, 21859, 29501, 37143, 44785, 52427, 60069anti-influenza_CDR 6576 14218, 21860, 29502, 37144, 44786, 52428, 60070anti-influenza_CDR 6577 14219, 21861, 29503, 37145, 44787, 52429, 60071anti-influenza_CDR 6578 14220, 21862, 29504, 37146, 44788, 52430, 60072anti-influenza_CDR 6579 14221, 21863, 29505, 37147, 44789, 52431, 60073anti-influenza_CDR 6580 14222, 21864, 29506, 37148, 44790, 52432, 60074anti-influenza_CDR 6581 14223, 21865, 29507, 37149, 44791, 52433, 60075anti-influenza_CDR 6582 14224, 21866, 29508, 37150, 44792, 52434, 60076anti-influenza_CDR 6583 14225, 21867, 29509, 37151, 44793, 52435, 60077anti-influenza_CDR 6584 14226, 21868, 29510, 37152, 44794, 52436, 60078anti-influenza_CDR 6585 14227, 21869, 29511, 37153, 44795, 52437, 60079anti-influenza_CDR 6586 14228, 21870, 29512, 37154, 44796, 52438, 60080anti-influenza_CDR 6587 14229, 21871, 29513, 37155, 44797, 52439, 60081anti-influenza_CDR 6588 14230, 21872, 29514, 37156, 44798, 52440, 60082anti-influenza_CDR 6589 14231, 21873, 29515, 37157, 44799, 52441, 60083anti-influenza_CDR 6590 14232, 21874, 29516, 37158, 44800, 52442, 60084anti-influenza_CDR 6591 14233, 21875, 29517, 37159, 44801, 52443, 60085anti-influenza_CDR 6592 14234, 21876, 29518, 37160, 44802, 52444, 60086anti-influenza_CDR 6593 14235, 21877, 29519, 37161, 44803, 52445, 60087anti-influenza_CDR 6594 14236, 21878, 29520, 37162, 44804, 52446, 60088anti-influenza_CDR 6595 14237, 21879, 29521, 37163, 44805, 52447, 60089anti-influenza_CDR 6596 14238, 21880, 29522, 37164, 44806, 52448, 60090anti-influenza_CDR 6597 14239, 21881, 29523, 37165, 44807, 52449, 60091anti-influenza_CDR 6598 14240, 21882, 29524, 37166, 44808, 52450, 60092anti-influenza_CDR 6599 14241, 21883, 29525, 37167, 44809, 52451, 60093anti-influenza_CDR 6600 14242, 21884, 29526, 37168, 44810, 52452, 60094anti-influenza_CDR 6601 14243, 21885, 29527, 37169, 44811, 52453, 60095anti-influenza_CDR 6602 14244, 21886, 29528, 37170, 44812, 52454, 60096anti-influenza_CDR 6603 14245, 21887, 29529, 37171, 44813, 52455, 60097anti-influenza_CDR 6604 14246, 21888, 29530, 37172, 44814, 52456, 60098anti-influenza_CDR 6605 14247, 21889, 29531, 37173, 44815, 52457, 60099anti-influenza_CDR 6606 14248, 21890, 29532, 37174, 44816, 52458, 60100anti-influenza_CDR 6607 14249, 21891, 29533, 37175, 44817, 52459, 60101anti-influenza_CDR 6608 14250, 21892, 29534, 37176, 44818, 52460, 60102anti-influenza_CDR 6609 14251, 21893, 29535, 37177, 44819, 52461, 60103anti-influenza_CDR 6610 14252, 21894, 29536, 37178, 44820, 52462, 60104anti-influenza_CDR 6611 14253, 21895, 29537, 37179, 44821, 52463, 60105anti-influenza_CDR 6612 14254, 21896, 29538, 37180, 44822, 52464, 60106anti-influenza_CDR 6613 14255, 21897, 29539, 37181, 44823, 52465, 60107anti-influenza_CDR 6614 14256, 21898, 29540, 37182, 44824, 52466, 60108anti-influenza_CDR 6615 14257, 21899, 29541, 37183, 44825, 52467, 60109anti-influenza_CDR 6616 14258, 21900, 29542, 37184, 44826, 52468, 60110anti-influenza_CDR 6617 14259, 21901, 29543, 37185, 44827, 52469, 60111anti-influenza_CDR 6618 14260, 21902, 29544, 37186, 44828, 52470, 60112anti-influenza_CDR 6619 14261, 21903, 29545, 37187, 44829, 52471, 60113anti-influenza_CDR 6620 14262, 21904, 29546, 37188, 44830, 52472, 60114anti-influenza_CDR 6621 14263, 21905, 29547, 37189, 44831, 52473, 60115anti-influenza_CDR 6622 14264, 21906, 29548, 37190, 44832, 52474, 60116anti-influenza_CDR 6623 14265, 21907, 29549, 37191, 44833, 52475, 60117anti-influenza_CDR 6624 14266, 21908, 29550, 37192, 44834, 52476, 60118anti-influenza_CDR 6625 14267, 21909, 29551, 37193, 44835, 52477, 60119anti-influenza_CDR 6626 14268, 21910, 29552, 37194, 44836, 52478, 60120anti-influenza_CDR 6627 14269, 21911, 29553, 37195, 44837, 52479, 60121anti-influenza_CDR 6628 14270, 21912, 29554, 37196, 44838, 52480, 60122anti-influenza_CDR 6629 14271, 21913, 29555, 37197, 44839, 52481, 60123anti-influenza_CDR 6630 14272, 21914, 29556, 37198, 44840, 52482, 60124anti-influenza_CDR 6631 14273, 21915, 29557, 37199, 44841, 52483, 60125anti-influenza_CDR 6632 14274, 21916, 29558, 37200, 44842, 52484, 60126anti-influenza_CDR 6633 14275, 21917, 29559, 37201, 44843, 52485, 60127anti-influenza_CDR 6634 14276, 21918, 29560, 37202, 44844, 52486, 60128anti-influenza_CDR 6635 14277, 21919, 29561, 37203, 44845, 52487, 60129anti-influenza_CDR 6636 14278, 21920, 29562, 37204, 44846, 52488, 60130anti-influenza_CDR 6637 14279, 21921, 29563, 37205, 44847, 52489, 60131anti-influenza_CDR 6638 14280, 21922, 29564, 37206, 44848, 52490, 60132anti-influenza_CDR 6639 14281, 21923, 29565, 37207, 44849, 52491, 60133anti-influenza_CDR 6640 14282, 21924, 29566, 37208, 44850, 52492, 60134anti-influenza_CDR 6641 14283, 21925, 29567, 37209, 44851, 52493, 60135anti-influenza_CDR 6642 14284, 21926, 29568, 37210, 44852, 52494, 60136anti-influenza_CDR 6643 14285, 21927, 29569, 37211, 44853, 52495, 60137anti-influenza_CDR 6644 14286, 21928, 29570, 37212, 44854, 52496, 60138anti-influenza_CDR 6645 14287, 21929, 29571, 37213, 44855, 52497, 60139anti-influenza_CDR 6646 14288, 21930, 29572, 37214, 44856, 52498, 60140anti-influenza_CDR 6647 14289, 21931, 29573, 37215, 44857, 52499, 60141anti-influenza_CDR 6648 14290, 21932, 29574, 37216, 44858, 52500, 60142anti-influenza_CDR 6649 14291, 21933, 29575, 37217, 44859, 52501, 60143anti-influenza_CDR 6650 14292, 21934, 29576, 37218, 44860, 52502, 60144anti-influenza_CDR 6651 14293, 21935, 29577, 37219, 44861, 52503, 60145anti-influenza_CDR 6652 14294, 21936, 29578, 37220, 44862, 52504, 60146anti-influenza_CDR 6653 14295, 21937, 29579, 37221, 44863, 52505, 60147anti-influenza_CDR 6654 14296, 21938, 29580, 37222, 44864, 52506, 60148anti-influenza_CDR 6655 14297, 21939, 29581, 37223, 44865, 52507, 60149anti-influenza_CDR 6656 14298, 21940, 29582, 37224, 44866, 52508, 60150anti-influenza_CDR 6657 14299, 21941, 29583, 37225, 44867, 52509, 60151anti-influenza_CDR 6658 14300, 21942, 29584, 37226, 44868, 52510, 60152anti-influenza_CDR 6659 14301, 21943, 29585, 37227, 44869, 52511, 60153anti-influenza_CDR 6660 14302, 21944, 29586, 37228, 44870, 52512, 60154anti-influenza_CDR 6661 14303, 21945, 29587, 37229, 44871, 52513, 60155anti-influenza_CDR 6662 14304, 21946, 29588, 37230, 44872, 52514, 60156anti-influenza_CDR 6663 14305, 21947, 29589, 37231, 44873, 52515, 60157anti-influenza_CDR 6664 14306, 21948, 29590, 37232, 44874, 52516, 60158anti-influenza_CDR 6665 14307, 21949, 29591, 37233, 44875, 52517, 60159anti-influenza_CDR 6666 14308, 21950, 29592, 37234, 44876, 52518, 60160anti-influenza_CDR 6667 14309, 21951, 29593, 37235, 44877, 52519, 60161anti-influenza_CDR 6668 14310, 21952, 29594, 37236, 44878, 52520, 60162anti-influenza_CDR 6669 14311, 21953, 29595, 37237, 44879, 52521, 60163anti-influenza_CDR 6670 14312, 21954, 29596, 37238, 44880, 52522, 60164anti-influenza_CDR 6671 14313, 21955, 29597, 37239, 44881, 52523, 60165anti-influenza_CDR 6672 14314, 21956, 29598, 37240, 44882, 52524, 60166anti-influenza_CDR 6673 14315, 21957, 29599, 37241, 44883, 52525, 60167anti-influenza_CDR 6674 14316, 21958, 29600, 37242, 44884, 52526, 60168anti-influenza_CDR 6675 14317, 21959, 29601, 37243, 44885, 52527, 60169anti-influenza_CDR 6676 14318, 21960, 29602, 37244, 44886, 52528, 60170anti-influenza_CDR 6677 14319, 21961, 29603, 37245, 44887, 52529, 60171anti-influenza_CDR 6678 14320, 21962, 29604, 37246, 44888, 52530, 60172anti-influenza_CDR 6679 14321, 21963, 29605, 37247, 44889, 52531, 60173anti-influenza_CDR 6680 14322, 21964, 29606, 37248, 44890, 52532, 60174anti-influenza_CDR 6681 14323, 21965, 29607, 37249, 44891, 52533, 60175anti-influenza_CDR 6682 14324, 21966, 29608, 37250, 44892, 52534, 60176anti-influenza_CDR 6683 14325, 21967, 29609, 37251, 44893, 52535, 60177anti-influenza_CDR 6684 14326, 21968, 29610, 37252, 44894, 52536, 60178anti-influenza_CDR 6685 14327, 21969, 29611, 37253, 44895, 52537, 60179anti-influenza_CDR 6686 14328, 21970, 29612, 37254, 44896, 52538, 60180anti-influenza_CDR 6687 14329, 21971, 29613, 37255, 44897, 52539, 60181anti-influenza_CDR 6688 14330, 21972, 29614, 37256, 44898, 52540, 60182anti-influenza_CDR 6689 14331, 21973, 29615, 37257, 44899, 52541, 60183anti-influenza_CDR 6690 14332, 21974, 29616, 37258, 44900, 52542, 60184anti-influenza_CDR 6691 14333, 21975, 29617, 37259, 44901, 52543, 60185anti-influenza_CDR 6692 14334, 21976, 29618, 37260, 44902, 52544, 60186anti-influenza_CDR 6693 14335, 21977, 29619, 37261, 44903, 52545, 60187anti-influenza_CDR 6694 14336, 21978, 29620, 37262, 44904, 52546, 60188anti-influenza_CDR 6695 14337, 21979, 29621, 37263, 44905, 52547, 60189anti-influenza_CDR 6696 14338, 21980, 29622, 37264, 44906, 52548, 60190anti-influenza_CDR 6697 14339, 21981, 29623, 37265, 44907, 52549, 60191anti-influenza_CDR 6698 14340, 21982, 29624, 37266, 44908, 52550, 60192anti-influenza_CDR 6699 14341, 21983, 29625, 37267, 44909, 52551, 60193anti-influenza_CDR 6700 14342, 21984, 29626, 37268, 44910, 52552, 60194anti-influenza_CDR 6701 14343, 21985, 29627, 37269, 44911, 52553, 60195anti-influenza_CDR 6702 14344, 21986, 29628, 37270, 44912, 52554, 60196anti-influenza_CDR 6703 14345, 21987, 29629, 37271, 44913, 52555, 60197anti-influenza_CDR 6704 14346, 21988, 29630, 37272, 44914, 52556, 60198anti-influenza_CDR 6705 14347, 21989, 29631, 37273, 44915, 52557, 60199anti-influenza_CDR 6706 14348, 21990, 29632, 37274, 44916, 52558, 60200anti-influenza_CDR 6707 14349, 21991, 29633, 37275, 44917, 52559, 60201anti-influenza_CDR 6708 14350, 21992, 29634, 37276, 44918, 52560, 60202anti-influenza_CDR 6709 14351, 21993, 29635, 37277, 44919, 52561, 60203anti-influenza_CDR 6710 14352, 21994, 29636, 37278, 44920, 52562, 60204anti-influenza_CDR 6711 14353, 21995, 29637, 37279, 44921, 52563, 60205anti-influenza_CDR 6712 14354, 21996, 29638, 37280, 44922, 52564, 60206anti-influenza_CDR 6713 14355, 21997, 29639, 37281, 44923, 52565, 60207anti-influenza_CDR 6714 14356, 21998, 29640, 37282, 44924, 52566, 60208anti-influenza_CDR 6715 14357, 21999, 29641, 37283, 44925, 52567, 60209anti-influenza_CDR 6716 14358, 22000, 29642, 37284, 44926, 52568, 60210anti-influenza_CDR 6717 14359, 22001, 29643, 37285, 44927, 52569, 60211anti-influenza_CDR 6718 14360, 22002, 29644, 37286, 44928, 52570, 60212anti-influenza_CDR 6719 14361, 22003, 29645, 37287, 44929, 52571, 60213anti-influenza_CDR 6720 14362, 22004, 29646, 37288, 44930, 52572, 60214anti-influenza_CDR 6721 14363, 22005, 29647, 37289, 44931, 52573, 60215anti-influenza_CDR 6722 14364, 22006, 29648, 37290, 44932, 52574, 60216anti-influenza_CDR 6723 14365, 22007, 29649, 37291, 44933, 52575, 60217anti-influenza_CDR 6724 14366, 22008, 29650, 37292, 44934, 52576, 60218anti-influenza_CDR 6725 14367, 22009, 29651, 37293, 44935, 52577, 60219anti-influenza_CDR 6726 14368, 22010, 29652, 37294, 44936, 52578, 60220anti-influenza_CDR 6727 14369, 22011, 29653, 37295, 44937, 52579, 60221anti-influenza_CDR 6728 14370, 22012, 29654, 37296, 44938, 52580, 60222anti-influenza_CDR 6729 14371, 22013, 29655, 37297, 44939, 52581, 60223anti-influenza_CDR 6730 14372, 22014, 29656, 37298, 44940, 52582, 60224anti-influenza_CDR 6731 14373, 22015, 29657, 37299, 44941, 52583, 60225anti-influenza_CDR 6732 14374, 22016, 29658, 37300, 44942, 52584, 60226anti-influenza_CDR 6733 14375, 22017, 29659, 37301, 44943, 52585, 60227anti-influenza_CDR 6734 14376, 22018, 29660, 37302, 44944, 52586, 60228anti-influenza_CDR 6735 14377, 22019, 29661, 37303, 44945, 52587, 60229anti-influenza_CDR 6736 14378, 22020, 29662, 37304, 44946, 52588, 60230anti-influenza_CDR 6737 14379, 22021, 29663, 37305, 44947, 52589, 60231anti-influenza_CDR 6738 14380, 22022, 29664, 37306, 44948, 52590, 60232anti-influenza_CDR 6739 14381, 22023, 29665, 37307, 44949, 52591, 60233anti-influenza_CDR 6740 14382, 22024, 29666, 37308, 44950, 52592, 60234anti-influenza_CDR 6741 14383, 22025, 29667, 37309, 44951, 52593, 60235anti-influenza_CDR 6742 14384, 22026, 29668, 37310, 44952, 52594, 60236anti-influenza_CDR 6743 14385, 22027, 29669, 37311, 44953, 52595, 60237anti-influenza_CDR 6744 14386, 22028, 29670, 37312, 44954, 52596, 60238anti-influenza_CDR 6745 14387, 22029, 29671, 37313, 44955, 52597, 60239anti-influenza_CDR 6746 14388, 22030, 29672, 37314, 44956, 52598, 60240anti-influenza_CDR 6747 14389, 22031, 29673, 37315, 44957, 52599, 60241anti-influenza_CDR 6748 14390, 22032, 29674, 37316, 44958, 52600, 60242anti-influenza_CDR 6749 14391, 22033, 29675, 37317, 44959, 52601, 60243anti-influenza_CDR 6750 14392, 22034, 29676, 37318, 44960, 52602, 60244anti-influenza_CDR 6751 14393, 22035, 29677, 37319, 44961, 52603, 60245anti-influenza_CDR 6752 14394, 22036, 29678, 37320, 44962, 52604, 60246anti-influenza_CDR 6753 14395, 22037, 29679, 37321, 44963, 52605, 60247anti-influenza_CDR 6754 14396, 22038, 29680, 37322, 44964, 52606, 60248anti-influenza_CDR 6755 14397, 22039, 29681, 37323, 44965, 52607, 60249anti-influenza_CDR 6756 14398, 22040, 29682, 37324, 44966, 52608, 60250anti-influenza_CDR 6757 14399, 22041, 29683, 37325, 44967, 52609, 60251anti-influenza_CDR 6758 14400, 22042, 29684, 37326, 44968, 52610, 60252anti-influenza_CDR 6759 14401, 22043, 29685, 37327, 44969, 52611, 60253anti-influenza_CDR 6760 14402, 22044, 29686, 37328, 44970, 52612, 60254anti-influenza_CDR 6761 14403, 22045, 29687, 37329, 44971, 52613, 60255anti-influenza_CDR 6762 14404, 22046, 29688, 37330, 44972, 52614, 60256anti-influenza_CDR 6763 14405, 22047, 29689, 37331, 44973, 52615, 60257anti-influenza_CDR 6764 14406, 22048, 29690, 37332, 44974, 52616, 60258anti-influenza_CDR 6765 14407, 22049, 29691, 37333, 44975, 52617, 60259anti-influenza_CDR 6766 14408, 22050, 29692, 37334, 44976, 52618, 60260anti-influenza_CDR 6767 14409, 22051, 29693, 37335, 44977, 52619, 60261anti-influenza_CDR 6768 14410, 22052, 29694, 37336, 44978, 52620, 60262anti-influenza_CDR 6769 14411, 22053, 29695, 37337, 44979, 52621, 60263anti-influenza_CDR 6770 14412, 22054, 29696, 37338, 44980, 52622, 60264anti-influenza_CDR 6771 14413, 22055, 29697, 37339, 44981, 52623, 60265anti-influenza_CDR 6772 14414, 22056, 29698, 37340, 44982, 52624, 60266anti-influenza_CDR 6773 14415, 22057, 29699, 37341, 44983, 52625, 60267anti-influenza_CDR 6774 14416, 22058, 29700, 37342, 44984, 52626, 60268anti-influenza_CDR 6775 14417, 22059, 29701, 37343, 44985, 52627, 60269anti-influenza_CDR 6776 14418, 22060, 29702, 37344, 44986, 52628, 60270anti-influenza_CDR 6777 14419, 22061, 29703, 37345, 44987, 52629, 60271anti-influenza_CDR 6778 14420, 22062, 29704, 37346, 44988, 52630, 60272anti-influenza_CDR 6779 14421, 22063, 29705, 37347, 44989, 52631, 60273anti-influenza_CDR 6780 14422, 22064, 29706, 37348, 44990, 52632, 60274anti-influenza_CDR 6781 14423, 22065, 29707, 37349, 44991, 52633, 60275anti-influenza_CDR 6782 14424, 22066, 29708, 37350, 44992, 52634, 60276anti-influenza_CDR 6783 14425, 22067, 29709, 37351, 44993, 52635, 60277anti-influenza_CDR 6784 14426, 22068, 29710, 37352, 44994, 52636, 60278anti-influenza_CDR 6785 14427, 22069, 29711, 37353, 44995, 52637, 60279anti-influenza_CDR 6786 14428, 22070, 29712, 37354, 44996, 52638, 60280anti-influenza_CDR 6787 14429, 22071, 29713, 37355, 44997, 52639, 60281anti-influenza_CDR 6788 14430, 22072, 29714, 37356, 44998, 52640, 60282anti-influenza_CDR 6789 14431, 22073, 29715, 37357, 44999, 52641, 60283anti-influenza_CDR 6790 14432, 22074, 29716, 37358, 45000, 52642, 60284anti-influenza_CDR 6791 14433, 22075, 29717, 37359, 45001, 52643, 60285anti-influenza_CDR 6792 14434, 22076, 29718, 37360, 45002, 52644, 60286anti-influenza_CDR 6793 14435, 22077, 29719, 37361, 45003, 52645, 60287anti-influenza_CDR 6794 14436, 22078, 29720, 37362, 45004, 52646, 60288anti-influenza_CDR 6795 14437, 22079, 29721, 37363, 45005, 52647, 60289anti-influenza_CDR 6796 14438, 22080, 29722, 37364, 45006, 52648, 60290anti-influenza_CDR 6797 14439, 22081, 29723, 37365, 45007, 52649, 60291anti-influenza_CDR 6798 14440, 22082, 29724, 37366, 45008, 52650, 60292anti-influenza_CDR 6799 14441, 22083, 29725, 37367, 45009, 52651, 60293anti-influenza_CDR 6800 14442, 22084, 29726, 37368, 45010, 52652, 60294anti-influenza_CDR 6801 14443, 22085, 29727, 37369, 45011, 52653, 60295anti-influenza_CDR 6802 14444, 22086, 29728, 37370, 45012, 52654, 60296anti-influenza_CDR 6803 14445, 22087, 29729, 37371, 45013, 52655, 60297anti-influenza_CDR 6804 14446, 22088, 29730, 37372, 45014, 52656, 60298anti-influenza_CDR 6805 14447, 22089, 29731, 37373, 45015, 52657, 60299anti-influenza_CDR 6806 14448, 22090, 29732, 37374, 45016, 52658, 60300anti-influenza_CDR 6807 14449, 22091, 29733, 37375, 45017, 52659, 60301anti-influenza_CDR 6808 14450, 22092, 29734, 37376, 45018, 52660, 60302anti-influenza_CDR 6809 14451, 22093, 29735, 37377, 45019, 52661, 60303anti-influenza_CDR 6810 14452, 22094, 29736, 37378, 45020, 52662, 60304anti-influenza_CDR 6811 14453, 22095, 29737, 37379, 45021, 52663, 60305anti-influenza_CDR 6812 14454, 22096, 29738, 37380, 45022, 52664, 60306anti-influenza_CDR 6813 14455, 22097, 29739, 37381, 45023, 52665, 60307anti-influenza_CDR 6814 14456, 22098, 29740, 37382, 45024, 52666, 60308anti-influenza_CDR 6815 14457, 22099, 29741, 37383, 45025, 52667, 60309anti-influenza_CDR 6816 14458, 22100, 29742, 37384, 45026, 52668, 60310anti-influenza_CDR 6817 14459, 22101, 29743, 37385, 45027, 52669, 60311anti-influenza_CDR 6818 14460, 22102, 29744, 37386, 45028, 52670, 60312anti-influenza_CDR 6819 14461, 22103, 29745, 37387, 45029, 52671, 60313anti-influenza_CDR 6820 14462, 22104, 29746, 37388, 45030, 52672, 60314anti-influenza_CDR 6821 14463, 22105, 29747, 37389, 45031, 52673, 60315anti-influenza_CDR 6822 14464, 22106, 29748, 37390, 45032, 52674, 60316anti-influenza_CDR 6823 14465, 22107, 29749, 37391, 45033, 52675, 60317anti-influenza_CDR 6824 14466, 22108, 29750, 37392, 45034, 52676, 60318anti-influenza_CDR 6825 14467, 22109, 29751, 37393, 45035, 52677, 60319anti-influenza_CDR 6826 14468, 22110, 29752, 37394, 45036, 52678, 60320anti-influenza_CDR 6827 14469, 22111, 29753, 37395, 45037, 52679, 60321anti-influenza_CDR 6828 14470, 22112, 29754, 37396, 45038, 52680, 60322anti-influenza_CDR 6829 14471, 22113, 29755, 37397, 45039, 52681, 60323anti-influenza_CDR 6830 14472, 22114, 29756, 37398, 45040, 52682, 60324anti-influenza_CDR 6831 14473, 22115, 29757, 37399, 45041, 52683, 60325anti-influenza_CDR 6832 14474, 22116, 29758, 37400, 45042, 52684, 60326anti-influenza_CDR 6833 14475, 22117, 29759, 37401, 45043, 52685, 60327anti-influenza_CDR 6834 14476, 22118, 29760, 37402, 45044, 52686, 60328anti-influenza_CDR 6835 14477, 22119, 29761, 37403, 45045, 52687, 60329anti-influenza_CDR 6836 14478, 22120, 29762, 37404, 45046, 52688, 60330anti-influenza_CDR 6837 14479, 22121, 29763, 37405, 45047, 52689, 60331anti-influenza_CDR 6838 14480, 22122, 29764, 37406, 45048, 52690, 60332anti-influenza_CDR 6839 14481, 22123, 29765, 37407, 45049, 52691, 60333anti-influenza_CDR 6840 14482, 22124, 29766, 37408, 45050, 52692, 60334anti-influenza_CDR 6841 14483, 22125, 29767, 37409, 45051, 52693, 60335anti-influenza_CDR 6842 14484, 22126, 29768, 37410, 45052, 52694, 60336anti-influenza_CDR 6843 14485, 22127, 29769, 37411, 45053, 52695, 60337anti-influenza_CDR 6844 14486, 22128, 29770, 37412, 45054, 52696, 60338anti-influenza_CDR 6845 14487, 22129, 29771, 37413, 45055, 52697, 60339anti-influenza_CDR 6846 14488, 22130, 29772, 37414, 45056, 52698, 60340anti-influenza_CDR 6847 14489, 22131, 29773, 37415, 45057, 52699, 60341anti-influenza_CDR 6848 14490, 22132, 29774, 37416, 45058, 52700, 60342anti-influenza_CDR 6849 14491, 22133, 29775, 37417, 45059, 52701, 60343anti-influenza_CDR 6850 14492, 22134, 29776, 37418, 45060, 52702, 60344anti-influenza_CDR 6851 14493, 22135, 29777, 37419, 45061, 52703, 60345anti-influenza_CDR 6852 14494, 22136, 29778, 37420, 45062, 52704, 60346anti-influenza_CDR 6853 14495, 22137, 29779, 37421, 45063, 52705, 60347anti-influenza_CDR 6854 14496, 22138, 29780, 37422, 45064, 52706, 60348anti-influenza_CDR 6855 14497, 22139, 29781, 37423, 45065, 52707, 60349anti-influenza_CDR 6856 14498, 22140, 29782, 37424, 45066, 52708, 60350anti-influenza_CDR 6857 14499, 22141, 29783, 37425, 45067, 52709, 60351anti-influenza_CDR 6858 14500, 22142, 29784, 37426, 45068, 52710, 60352anti-influenza_CDR 6859 14501, 22143, 29785, 37427, 45069, 52711, 60353anti-influenza_CDR 6860 14502, 22144, 29786, 37428, 45070, 52712, 60354anti-influenza_CDR 6861 14503, 22145, 29787, 37429, 45071, 52713, 60355anti-influenza_CDR 6862 14504, 22146, 29788, 37430, 45072, 52714, 60356anti-influenza_CDR 6863 14505, 22147, 29789, 37431, 45073, 52715, 60357anti-influenza_CDR 6864 14506, 22148, 29790, 37432, 45074, 52716, 60358anti-influenza_CDR 6865 14507, 22149, 29791, 37433, 45075, 52717, 60359anti-influenza_CDR 6866 14508, 22150, 29792, 37434, 45076, 52718, 60360anti-influenza_CDR 6867 14509, 22151, 29793, 37435, 45077, 52719, 60361anti-influenza_CDR 6868 14510, 22152, 29794, 37436, 45078, 52720, 60362anti-influenza_CDR 6869 14511, 22153, 29795, 37437, 45079, 52721, 60363anti-influenza_CDR 6870 14512, 22154, 29796, 37438, 45080, 52722, 60364anti-influenza_CDR 6871 14513, 22155, 29797, 37439, 45081, 52723, 60365anti-influenza_CDR 6872 14514, 22156, 29798, 37440, 45082, 52724, 60366anti-influenza_CDR 6873 14515, 22157, 29799, 37441, 45083, 52725, 60367anti-influenza_CDR 6874 14516, 22158, 29800, 37442, 45084, 52726, 60368anti-influenza_CDR 6875 14517, 22159, 29801, 37443, 45085, 52727, 60369anti-influenza_CDR 6876 14518, 22160, 29802, 37444, 45086, 52728, 60370anti-influenza_CDR 6877 14519, 22161, 29803, 37445, 45087, 52729, 60371anti-influenza_CDR 6878 14520, 22162, 29804, 37446, 45088, 52730, 60372anti-influenza_CDR 6879 14521, 22163, 29805, 37447, 45089, 52731, 60373anti-influenza_CDR 6880 14522, 22164, 29806, 37448, 45090, 52732, 60374anti-influenza_CDR 6881 14523, 22165, 29807, 37449, 45091, 52733, 60375anti-influenza_CDR 6882 14524, 22166, 29808, 37450, 45092, 52734, 60376anti-influenza_CDR 6883 14525, 22167, 29809, 37451, 45093, 52735, 60377anti-influenza_CDR 6884 14526, 22168, 29810, 37452, 45094, 52736, 60378anti-influenza_CDR 6885 14527, 22169, 29811, 37453, 45095, 52737, 60379anti-influenza_CDR 6886 14528, 22170, 29812, 37454, 45096, 52738, 60380anti-influenza_CDR 6887 14529, 22171, 29813, 37455, 45097, 52739, 60381anti-influenza_CDR 6888 14530, 22172, 29814, 37456, 45098, 52740, 60382anti-influenza_CDR 6889 14531, 22173, 29815, 37457, 45099, 52741, 60383anti-influenza_CDR 6890 14532, 22174, 29816, 37458, 45100, 52742, 60384anti-influenza_CDR 6891 14533, 22175, 29817, 37459, 45101, 52743, 60385anti-influenza_CDR 6892 14534, 22176, 29818, 37460, 45102, 52744, 60386anti-influenza_CDR 6893 14535, 22177, 29819, 37461, 45103, 52745, 60387anti-influenza_CDR 6894 14536, 22178, 29820, 37462, 45104, 52746, 60388anti-influenza_CDR 6895 14537, 22179, 29821, 37463, 45105, 52747, 60389anti-influenza_CDR 6896 14538, 22180, 29822, 37464, 45106, 52748, 60390anti-influenza_CDR 6897 14539, 22181, 29823, 37465, 45107, 52749, 60391anti-influenza_CDR 6898 14540, 22182, 29824, 37466, 45108, 52750, 60392anti-influenza_CDR 6899 14541, 22183, 29825, 37467, 45109, 52751, 60393anti-influenza_CDR 6900 14542, 22184, 29826, 37468, 45110, 52752, 60394anti-influenza_CDR 6901 14543, 22185, 29827, 37469, 45111, 52753, 60395anti-influenza_CDR 6902 14544, 22186, 29828, 37470, 45112, 52754, 60396anti-influenza_CDR 6903 14545, 22187, 29829, 37471, 45113, 52755, 60397anti-influenza_CDR 6904 14546, 22188, 29830, 37472, 45114, 52756, 60398anti-influenza_CDR 6905 14547, 22189, 29831, 37473, 45115, 52757, 60399anti-influenza_CDR 6906 14548, 22190, 29832, 37474, 45116, 52758, 60400anti-influenza_CDR 6907 14549, 22191, 29833, 37475, 45117, 52759, 60401anti-influenza_CDR 6908 14550, 22192, 29834, 37476, 45118, 52760, 60402anti-influenza_CDR 6909 14551, 22193, 29835, 37477, 45119, 52761, 60403anti-influenza_CDR 6910 14552, 22194, 29836, 37478, 45120, 52762, 60404anti-influenza_CDR 6911 14553, 22195, 29837, 37479, 45121, 52763, 60405anti-influenza_CDR 6912 14554, 22196, 29838, 37480, 45122, 52764, 60406anti-influenza_CDR 6913 14555, 22197, 29839, 37481, 45123, 52765, 60407anti-influenza_CDR 6914 14556, 22198, 29840, 37482, 45124, 52766, 60408anti-influenza_CDR 6915 14557, 22199, 29841, 37483, 45125, 52767, 60409anti-influenza_CDR 6916 14558, 22200, 29842, 37484, 45126, 52768, 60410anti-influenza_CDR 6917 14559, 22201, 29843, 37485, 45127, 52769, 60411anti-influenza_CDR 6918 14560, 22202, 29844, 37486, 45128, 52770, 60412anti-influenza_CDR 6919 14561, 22203, 29845, 37487, 45129, 52771, 60413anti-influenza_CDR 6920 14562, 22204, 29846, 37488, 45130, 52772, 60414anti-influenza_CDR 6921 14563, 22205, 29847, 37489, 45131, 52773, 60415anti-influenza_CDR 6922 14564, 22206, 29848, 37490, 45132, 52774, 60416anti-influenza_CDR 6923 14565, 22207, 29849, 37491, 45133, 52775, 60417anti-influenza_CDR 6924 14566, 22208, 29850, 37492, 45134, 52776, 60418anti-influenza_CDR 6925 14567, 22209, 29851, 37493, 45135, 52777, 60419anti-influenza_CDR 6926 14568, 22210, 29852, 37494, 45136, 52778, 60420anti-influenza_CDR 6927 14569, 22211, 29853, 37495, 45137, 52779, 60421anti-influenza_CDR 6928 14570, 22212, 29854, 37496, 45138, 52780, 60422anti-influenza_CDR 6929 14571, 22213, 29855, 37497, 45139, 52781, 60423anti-influenza_CDR 6930 14572, 22214, 29856, 37498, 45140, 52782, 60424anti-influenza_CDR 6931 14573, 22215, 29857, 37499, 45141, 52783, 60425anti-influenza_CDR 6932 14574, 22216, 29858, 37500, 45142, 52784, 60426anti-influenza_CDR 6933 14575, 22217, 29859, 37501, 45143, 52785, 60427anti-influenza_CDR 6934 14576, 22218, 29860, 37502, 45144, 52786, 60428anti-influenza_CDR 6935 14577, 22219, 29861, 37503, 45145, 52787, 60429anti-influenza_CDR 6936 14578, 22220, 29862, 37504, 45146, 52788, 60430anti-influenza_CDR 6937 14579, 22221, 29863, 37505, 45147, 52789, 60431anti-influenza_CDR 6938 14580, 22222, 29864, 37506, 45148, 52790, 60432anti-influenza_CDR 6939 14581, 22223, 29865, 37507, 45149, 52791, 60433anti-influenza_CDR 6940 14582, 22224, 29866, 37508, 45150, 52792, 60434anti-influenza_CDR 6941 14583, 22225, 29867, 37509, 45151, 52793, 60435anti-influenza_CDR 6942 14584, 22226, 29868, 37510, 45152, 52794, 60436anti-influenza_CDR 6943 14585, 22227, 29869, 37511, 45153, 52795, 60437anti-influenza_CDR 6944 14586, 22228, 29870, 37512, 45154, 52796, 60438anti-influenza_CDR 6945 14587, 22229, 29871, 37513, 45155, 52797, 60439anti-influenza_CDR 6946 14588, 22230, 29872, 37514, 45156, 52798, 60440anti-influenza_CDR 6947 14589, 22231, 29873, 37515, 45157, 52799, 60441anti-influenza_CDR 6948 14590, 22232, 29874, 37516, 45158, 52800, 60442anti-influenza_CDR 6949 14591, 22233, 29875, 37517, 45159, 52801, 60443anti-influenza_CDR 6950 14592, 22234, 29876, 37518, 45160, 52802, 60444anti-influenza_CDR 6951 14593, 22235, 29877, 37519, 45161, 52803, 60445anti-influenza_CDR 6952 14594, 22236, 29878, 37520, 45162, 52804, 60446anti-influenza_CDR 6953 14595, 22237, 29879, 37521, 45163, 52805, 60447anti-influenza_CDR 6954 14596, 22238, 29880, 37522, 45164, 52806, 60448anti-influenza_CDR 6955 14597, 22239, 29881, 37523, 45165, 52807, 60449anti-influenza_CDR 6956 14598, 22240, 29882, 37524, 45166, 52808, 60450anti-influenza_CDR 6957 14599, 22241, 29883, 37525, 45167, 52809, 60451anti-influenza_CDR 6958 14600, 22242, 29884, 37526, 45168, 52810, 60452anti-influenza_CDR 6959 14601, 22243, 29885, 37527, 45169, 52811, 60453anti-influenza_CDR 6960 14602, 22244, 29886, 37528, 45170, 52812, 60454anti-influenza_CDR 6961 14603, 22245, 29887, 37529, 45171, 52813, 60455anti-influenza_CDR 6962 14604, 22246, 29888, 37530, 45172, 52814, 60456anti-influenza_CDR 6963 14605, 22247, 29889, 37531, 45173, 52815, 60457anti-influenza_CDR 6964 14606, 22248, 29890, 37532, 45174, 52816, 60458anti-influenza_CDR 6965 14607, 22249, 29891, 37533, 45175, 52817, 60459anti-influenza_CDR 6966 14608, 22250, 29892, 37534, 45176, 52818, 60460anti-influenza_CDR 6967 14609, 22251, 29893, 37535, 45177, 52819, 60461anti-influenza_CDR 6968 14610, 22252, 29894, 37536, 45178, 52820, 60462anti-influenza_CDR 6969 14611, 22253, 29895, 37537, 45179, 52821, 60463anti-influenza_CDR 6970 14612, 22254, 29896, 37538, 45180, 52822, 60464anti-influenza_CDR 6971 14613, 22255, 29897, 37539, 45181, 52823, 60465anti-influenza_CDR 6972 14614, 22256, 29898, 37540, 45182, 52824, 60466anti-influenza_CDR 6973 14615, 22257, 29899, 37541, 45183, 52825, 60467anti-influenza_CDR 6974 14616, 22258, 29900, 37542, 45184, 52826, 60468anti-influenza_CDR 6975 14617, 22259, 29901, 37543, 45185, 52827, 60469anti-influenza_CDR 6976 14618, 22260, 29902, 37544, 45186, 52828, 60470anti-influenza_CDR 6977 14619, 22261, 29903, 37545, 45187, 52829, 60471anti-influenza_CDR 6978 14620, 22262, 29904, 37546, 45188, 52830, 60472anti-influenza_CDR 6979 14621, 22263, 29905, 37547, 45189, 52831, 60473anti-influenza_CDR 6980 14622, 22264, 29906, 37548, 45190, 52832, 60474anti-influenza_CDR 6981 14623, 22265, 29907, 37549, 45191, 52833, 60475anti-influenza_CDR 6982 14624, 22266, 29908, 37550, 45192, 52834, 60476anti-influenza_CDR 6983 14625, 22267, 29909, 37551, 45193, 52835, 60477anti-influenza_CDR 6984 14626, 22268, 29910, 37552, 45194, 52836, 60478anti-influenza_CDR 6985 14627, 22269, 29911, 37553, 45195, 52837, 60479anti-influenza_CDR 6986 14628, 22270, 29912, 37554, 45196, 52838, 60480anti-influenza_CDR 6987 14629, 22271, 29913, 37555, 45197, 52839, 60481anti-influenza_CDR 6988 14630, 22272, 29914, 37556, 45198, 52840, 60482anti-influenza_CDR 6989 14631, 22273, 29915, 37557, 45199, 52841, 60483anti-influenza_CDR 6990 14632, 22274, 29916, 37558, 45200, 52842, 60484anti-influenza_CDR 6991 14633, 22275, 29917, 37559, 45201, 52843, 60485anti-influenza_CDR 6992 14634, 22276, 29918, 37560, 45202, 52844, 60486anti-influenza_CDR 6993 14635, 22277, 29919, 37561, 45203, 52845, 60487anti-influenza_CDR 6994 14636, 22278, 29920, 37562, 45204, 52846, 60488anti-influenza_CDR 6995 14637, 22279, 29921, 37563, 45205, 52847, 60489anti-influenza_CDR 6996 14638, 22280, 29922, 37564, 45206, 52848, 60490anti-influenza_CDR 6997 14639, 22281, 29923, 37565, 45207, 52849, 60491anti-influenza_CDR 6998 14640, 22282, 29924, 37566, 45208, 52850, 60492anti-influenza_CDR 6999 14641, 22283, 29925, 37567, 45209, 52851, 60493anti-influenza_CDR 7000 14642, 22284, 29926, 37568, 45210, 52852, 60494anti-influenza_CDR 7001 14643, 22285, 29927, 37569, 45211, 52853, 60495anti-influenza_CDR 7002 14644, 22286, 29928, 37570, 45212, 52854, 60496anti-influenza_CDR 7003 14645, 22287, 29929, 37571, 45213, 52855, 60497anti-influenza_CDR 7004 14646, 22288, 29930, 37572, 45214, 52856, 60498anti-influenza_CDR 7005 14647, 22289, 29931, 37573, 45215, 52857, 60499anti-influenza_CDR 7006 14648, 22290, 29932, 37574, 45216, 52858, 60500anti-influenza_CDR 7007 14649, 22291, 29933, 37575, 45217, 52859, 60501anti-influenza_CDR 7008 14650, 22292, 29934, 37576, 45218, 52860, 60502anti-influenza_CDR 7009 14651, 22293, 29935, 37577, 45219, 52861, 60503anti-influenza_CDR 7010 14652, 22294, 29936, 37578, 45220, 52862, 60504anti-influenza_CDR 7011 14653, 22295, 29937, 37579, 45221, 52863, 60505anti-influenza_CDR 7012 14654, 22296, 29938, 37580, 45222, 52864, 60506anti-influenza_CDR 7013 14655, 22297, 29939, 37581, 45223, 52865, 60507anti-influenza_CDR 7014 14656, 22298, 29940, 37582, 45224, 52866, 60508anti-influenza_CDR 7015 14657, 22299, 29941, 37583, 45225, 52867, 60509anti-influenza_CDR 7016 14658, 22300, 29942, 37584, 45226, 52868, 60510anti-influenza_CDR 7017 14659, 22301, 29943, 37585, 45227, 52869, 60511anti-influenza_CDR 7018 14660, 22302, 29944, 37586, 45228, 52870, 60512anti-influenza_CDR 7019 14661, 22303, 29945, 37587, 45229, 52871, 60513anti-influenza_CDR 7020 14662, 22304, 29946, 37588, 45230, 52872, 60514anti-influenza_CDR 7021 14663, 22305, 29947, 37589, 45231, 52873, 60515anti-influenza_CDR 7022 14664, 22306, 29948, 37590, 45232, 52874, 60516anti-influenza_CDR 7023 14665, 22307, 29949, 37591, 45233, 52875, 60517anti-influenza_CDR 7024 14666, 22308, 29950, 37592, 45234, 52876, 60518anti-influenza_CDR 7025 14667, 22309, 29951, 37593, 45235, 52877, 60519anti-influenza_CDR 7026 14668, 22310, 29952, 37594, 45236, 52878, 60520anti-influenza_CDR 7027 14669, 22311, 29953, 37595, 45237, 52879, 60521anti-influenza_CDR 7028 14670, 22312, 29954, 37596, 45238, 52880, 60522anti-influenza_CDR 7029 14671, 22313, 29955, 37597, 45239, 52881, 60523anti-influenza_CDR 7030 14672, 22314, 29956, 37598, 45240, 52882, 60524anti-influenza_CDR 7031 14673, 22315, 29957, 37599, 45241, 52883, 60525anti-influenza_CDR 7032 14674, 22316, 29958, 37600, 45242, 52884, 60526anti-influenza_CDR 7033 14675, 22317, 29959, 37601, 45243, 52885, 60527anti-influenza_CDR 7034 14676, 22318, 29960, 37602, 45244, 52886, 60528anti-influenza_CDR 7035 14677, 22319, 29961, 37603, 45245, 52887, 60529anti-influenza_CDR 7036 14678, 22320, 29962, 37604, 45246, 52888, 60530anti-influenza_CDR 7037 14679, 22321, 29963, 37605, 45247, 52889, 60531anti-influenza_CDR 7038 14680, 22322, 29964, 37606, 45248, 52890, 60532anti-influenza_CDR 7039 14681, 22323, 29965, 37607, 45249, 52891, 60533anti-influenza_CDR 7040 14682, 22324, 29966, 37608, 45250, 52892, 60534anti-influenza_CDR 7041 14683, 22325, 29967, 37609, 45251, 52893, 60535anti-influenza_CDR 7042 14684, 22326, 29968, 37610, 45252, 52894, 60536anti-influenza_CDR 7043 14685, 22327, 29969, 37611, 45253, 52895, 60537anti-influenza_CDR 7044 14686, 22328, 29970, 37612, 45254, 52896, 60538anti-influenza_CDR 7045 14687, 22329, 29971, 37613, 45255, 52897, 60539anti-influenza_CDR 7046 14688, 22330, 29972, 37614, 45256, 52898, 60540anti-influenza_CDR 7047 14689, 22331, 29973, 37615, 45257, 52899, 60541anti-influenza_CDR 7048 14690, 22332, 29974, 37616, 45258, 52900, 60542anti-influenza_CDR 7049 14691, 22333, 29975, 37617, 45259, 52901, 60543anti-influenza_CDR 7050 14692, 22334, 29976, 37618, 45260, 52902, 60544anti-influenza_CDR 7051 14693, 22335, 29977, 37619, 45261, 52903, 60545anti-influenza_CDR 7052 14694, 22336, 29978, 37620, 45262, 52904, 60546anti-influenza_CDR 7053 14695, 22337, 29979, 37621, 45263, 52905, 60547anti-influenza_CDR 7054 14696, 22338, 29980, 37622, 45264, 52906, 60548anti-influenza_CDR 7055 14697, 22339, 29981, 37623, 45265, 52907, 60549anti-influenza_CDR 7056 14698, 22340, 29982, 37624, 45266, 52908, 60550anti-influenza_CDR 7057 14699, 22341, 29983, 37625, 45267, 52909, 60551anti-influenza_CDR 7058 14700, 22342, 29984, 37626, 45268, 52910, 60552anti-influenza_CDR 7059 14701, 22343, 29985, 37627, 45269, 52911, 60553anti-influenza_CDR 7060 14702, 22344, 29986, 37628, 45270, 52912, 60554anti-influenza_CDR 7061 14703, 22345, 29987, 37629, 45271, 52913, 60555anti-influenza_CDR 7062 14704, 22346, 29988, 37630, 45272, 52914, 60556anti-influenza_CDR 7063 14705, 22347, 29989, 37631, 45273, 52915, 60557anti-influenza_CDR 7064 14706, 22348, 29990, 37632, 45274, 52916, 60558anti-influenza_CDR 7065 14707, 22349, 29991, 37633, 45275, 52917, 60559anti-influenza_CDR 7066 14708, 22350, 29992, 37634, 45276, 52918, 60560anti-influenza_CDR 7067 14709, 22351, 29993, 37635, 45277, 52919, 60561anti-influenza_CDR 7068 14710, 22352, 29994, 37636, 45278, 52920, 60562anti-influenza_CDR 7069 14711, 22353, 29995, 37637, 45279, 52921, 60563anti-influenza_CDR 7070 14712, 22354, 29996, 37638, 45280, 52922, 60564anti-influenza_CDR 7071 14713, 22355, 29997, 37639, 45281, 52923, 60565anti-influenza_CDR 7072 14714, 22356, 29998, 37640, 45282, 52924, 60566anti-influenza_CDR 7073 14715, 22357, 29999, 37641, 45283, 52925, 60567anti-influenza_CDR 7074 14716, 22358, 30000, 37642, 45284, 52926, 60568anti-influenza_CDR 7075 14717, 22359, 30001, 37643, 45285, 52927, 60569anti-influenza_CDR 7076 14718, 22360, 30002, 37644, 45286, 52928, 60570anti-influenza_CDR 7077 14719, 22361, 30003, 37645, 45287, 52929, 60571anti-influenza_CDR 7078 14720, 22362, 30004, 37646, 45288, 52930, 60572anti-influenza_CDR 7079 14721, 22363, 30005, 37647, 45289, 52931, 60573anti-influenza_CDR 7080 14722, 22364, 30006, 37648, 45290, 52932, 60574anti-influenza_CDR 7081 14723, 22365, 30007, 37649, 45291, 52933, 60575anti-influenza_CDR 7082 14724, 22366, 30008, 37650, 45292, 52934, 60576anti-influenza_CDR 7083 14725, 22367, 30009, 37651, 45293, 52935, 60577anti-influenza_CDR 7084 14726, 22368, 30010, 37652, 45294, 52936, 60578anti-influenza_CDR 7085 14727, 22369, 30011, 37653, 45295, 52937, 60579anti-influenza_CDR 7086 14728, 22370, 30012, 37654, 45296, 52938, 60580anti-influenza_CDR 7087 14729, 22371, 30013, 37655, 45297, 52939, 60581anti-influenza_CDR 7088 14730, 22372, 30014, 37656, 45298, 52940, 60582anti-influenza_CDR 7089 14731, 22373, 30015, 37657, 45299, 52941, 60583anti-influenza_CDR 7090 14732, 22374, 30016, 37658, 45300, 52942, 60584anti-influenza_CDR 7091 14733, 22375, 30017, 37659, 45301, 52943, 60585anti-influenza_CDR 7092 14734, 22376, 30018, 37660, 45302, 52944, 60586anti-influenza_CDR 7093 14735, 22377, 30019, 37661, 45303, 52945, 60587anti-influenza_CDR 7094 14736, 22378, 30020, 37662, 45304, 52946, 60588anti-influenza_CDR 7095 14737, 22379, 30021, 37663, 45305, 52947, 60589anti-influenza_CDR 7096 14738, 22380, 30022, 37664, 45306, 52948, 60590anti-influenza_CDR 7097 14739, 22381, 30023, 37665, 45307, 52949, 60591anti-influenza_CDR 7098 14740, 22382, 30024, 37666, 45308, 52950, 60592anti-influenza_CDR 7099 14741, 22383, 30025, 37667, 45309, 52951, 60593anti-influenza_CDR 7100 14742, 22384, 30026, 37668, 45310, 52952, 60594anti-influenza_CDR 7101 14743, 22385, 30027, 37669, 45311, 52953, 60595anti-influenza_CDR 7102 14744, 22386, 30028, 37670, 45312, 52954, 60596anti-influenza_CDR 7103 14745, 22387, 30029, 37671, 45313, 52955, 60597anti-influenza_CDR 7104 14746, 22388, 30030, 37672, 45314, 52956, 60598anti-influenza_CDR 7105 14747, 22389, 30031, 37673, 45315, 52957, 60599anti-influenza_CDR 7106 14748, 22390, 30032, 37674, 45316, 52958, 60600anti-influenza_CDR 7107 14749, 22391, 30033, 37675, 45317, 52959, 60601anti-influenza_CDR 7108 14750, 22392, 30034, 37676, 45318, 52960, 60602anti-influenza_CDR 7109 14751, 22393, 30035, 37677, 45319, 52961, 60603anti-influenza_CDR 7110 14752, 22394, 30036, 37678, 45320, 52962, 60604anti-influenza_CDR 7111 14753, 22395, 30037, 37679, 45321, 52963, 60605anti-influenza_CDR 7112 14754, 22396, 30038, 37680, 45322, 52964, 60606anti-influenza_CDR 7113 14755, 22397, 30039, 37681, 45323, 52965, 60607anti-influenza_CDR 7114 14756, 22398, 30040, 37682, 45324, 52966, 60608anti-influenza_CDR 7115 14757, 22399, 30041, 37683, 45325, 52967, 60609anti-influenza_CDR 7116 14758, 22400, 30042, 37684, 45326, 52968, 60610anti-influenza_CDR 7117 14759, 22401, 30043, 37685, 45327, 52969, 60611anti-influenza_CDR 7118 14760, 22402, 30044, 37686, 45328, 52970, 60612anti-influenza_CDR 7119 14761, 22403, 30045, 37687, 45329, 52971, 60613anti-influenza_CDR 7120 14762, 22404, 30046, 37688, 45330, 52972, 60614anti-influenza_CDR 7121 14763, 22405, 30047, 37689, 45331, 52973, 60615anti-influenza_CDR 7122 14764, 22406, 30048, 37690, 45332, 52974, 60616anti-influenza_CDR 7123 14765, 22407, 30049, 37691, 45333, 52975, 60617anti-influenza_CDR 7124 14766, 22408, 30050, 37692, 45334, 52976, 60618anti-influenza_CDR 7125 14767, 22409, 30051, 37693, 45335, 52977, 60619anti-influenza_CDR 7126 14768, 22410, 30052, 37694, 45336, 52978, 60620anti-influenza_CDR 7127 14769, 22411, 30053, 37695, 45337, 52979, 60621anti-influenza_CDR 7128 14770, 22412, 30054, 37696, 45338, 52980, 60622anti-influenza_CDR 7129 14771, 22413, 30055, 37697, 45339, 52981, 60623anti-influenza_CDR 7130 14772, 22414, 30056, 37698, 45340, 52982, 60624anti-influenza_CDR 7131 14773, 22415, 30057, 37699, 45341, 52983, 60625anti-influenza_CDR 7132 14774, 22416, 30058, 37700, 45342, 52984, 60626anti-influenza_CDR 7133 14775, 22417, 30059, 37701, 45343, 52985, 60627anti-influenza_CDR 7134 14776, 22418, 30060, 37702, 45344, 52986, 60628anti-influenza_CDR 7135 14777, 22419, 30061, 37703, 45345, 52987, 60629anti-influenza_CDR 7136 14778, 22420, 30062, 37704, 45346, 52988, 60630anti-influenza_CDR 7137 14779, 22421, 30063, 37705, 45347, 52989, 60631anti-influenza_CDR 7138 14780, 22422, 30064, 37706, 45348, 52990, 60632anti-influenza_CDR 7139 14781, 22423, 30065, 37707, 45349, 52991, 60633anti-influenza_CDR 7140 14782, 22424, 30066, 37708, 45350, 52992, 60634anti-influenza_CDR 7141 14783, 22425, 30067, 37709, 45351, 52993, 60635anti-influenza_CDR 7142 14784, 22426, 30068, 37710, 45352, 52994, 60636anti-influenza_CDR 7143 14785, 22427, 30069, 37711, 45353, 52995, 60637anti-influenza_CDR 7144 14786, 22428, 30070, 37712, 45354, 52996, 60638anti-influenza_CDR 7145 14787, 22429, 30071, 37713, 45355, 52997, 60639anti-influenza_CDR 7146 14788, 22430, 30072, 37714, 45356, 52998, 60640anti-influenza_CDR 7147 14789, 22431, 30073, 37715, 45357, 52999, 60641anti-influenza_CDR 7148 14790, 22432, 30074, 37716, 45358, 53000, 60642anti-influenza_CDR 7149 14791, 22433, 30075, 37717, 45359, 53001, 60643anti-influenza_CDR 7150 14792, 22434, 30076, 37718, 45360, 53002, 60644anti-influenza_CDR 7151 14793, 22435, 30077, 37719, 45361, 53003, 60645anti-influenza_CDR 7152 14794, 22436, 30078, 37720, 45362, 53004, 60646anti-influenza_CDR 7153 14795, 22437, 30079, 37721, 45363, 53005, 60647anti-influenza_CDR 7154 14796, 22438, 30080, 37722, 45364, 53006, 60648anti-influenza_CDR 7155 14797, 22439, 30081, 37723, 45365, 53007, 60649anti-influenza_CDR 7156 14798, 22440, 30082, 37724, 45366, 53008, 60650anti-influenza_CDR 7157 14799, 22441, 30083, 37725, 45367, 53009, 60651anti-influenza_CDR 7158 14800, 22442, 30084, 37726, 45368, 53010, 60652anti-influenza_CDR 7159 14801, 22443, 30085, 37727, 45369, 53011, 60653anti-influenza_CDR 7160 14802, 22444, 30086, 37728, 45370, 53012, 60654anti-influenza_CDR 7161 14803, 22445, 30087, 37729, 45371, 53013, 60655anti-influenza_CDR 7162 14804, 22446, 30088, 37730, 45372, 53014, 60656anti-influenza_CDR 7163 14805, 22447, 30089, 37731, 45373, 53015, 60657anti-influenza_CDR 7164 14806, 22448, 30090, 37732, 45374, 53016, 60658anti-influenza_CDR 7165 14807, 22449, 30091, 37733, 45375, 53017, 60659anti-influenza_CDR 7166 14808, 22450, 30092, 37734, 45376, 53018, 60660anti-influenza_CDR 7167 14809, 22451, 30093, 37735, 45377, 53019, 60661anti-influenza_CDR 7168 14810, 22452, 30094, 37736, 45378, 53020, 60662anti-influenza_CDR 7169 14811, 22453, 30095, 37737, 45379, 53021, 60663anti-influenza_CDR 7170 14812, 22454, 30096, 37738, 45380, 53022, 60664anti-influenza_CDR 7171 14813, 22455, 30097, 37739, 45381, 53023, 60665anti-influenza_CDR 7172 14814, 22456, 30098, 37740, 45382, 53024, 60666anti-influenza_CDR 7173 14815, 22457, 30099, 37741, 45383, 53025, 60667anti-influenza_CDR 7174 14816, 22458, 30100, 37742, 45384, 53026, 60668anti-influenza_CDR 7175 14817, 22459, 30101, 37743, 45385, 53027, 60669anti-influenza_CDR 7176 14818, 22460, 30102, 37744, 45386, 53028, 60670anti-influenza_CDR 7177 14819, 22461, 30103, 37745, 45387, 53029, 60671anti-influenza_CDR 7178 14820, 22462, 30104, 37746, 45388, 53030, 60672anti-influenza_CDR 7179 14821, 22463, 30105, 37747, 45389, 53031, 60673anti-influenza_CDR 7180 14822, 22464, 30106, 37748, 45390, 53032, 60674anti-influenza_CDR 7181 14823, 22465, 30107, 37749, 45391, 53033, 60675anti-influenza_CDR 7182 14824, 22466, 30108, 37750, 45392, 53034, 60676anti-influenza_CDR 7183 14825, 22467, 30109, 37751, 45393, 53035, 60677anti-influenza_CDR 7184 14826, 22468, 30110, 37752, 45394, 53036, 60678anti-influenza_CDR 7185 14827, 22469, 30111, 37753, 45395, 53037, 60679anti-influenza_CDR 7186 14828, 22470, 30112, 37754, 45396, 53038, 60680anti-influenza_CDR 7187 14829, 22471, 30113, 37755, 45397, 53039, 60681anti-influenza_CDR 7188 14830, 22472, 30114, 37756, 45398, 53040, 60682anti-influenza_CDR 7189 14831, 22473, 30115, 37757, 45399, 53041, 60683anti-influenza_CDR 7190 14832, 22474, 30116, 37758, 45400, 53042, 60684anti-influenza_CDR 7191 14833, 22475, 30117, 37759, 45401, 53043, 60685anti-influenza_CDR 7192 14834, 22476, 30118, 37760, 45402, 53044, 60686anti-influenza_CDR 7193 14835, 22477, 30119, 37761, 45403, 53045, 60687anti-influenza_CDR 7194 14836, 22478, 30120, 37762, 45404, 53046, 60688anti-influenza_CDR 7195 14837, 22479, 30121, 37763, 45405, 53047, 60689anti-influenza_CDR 7196 14838, 22480, 30122, 37764, 45406, 53048, 60690anti-influenza_CDR 7197 14839, 22481, 30123, 37765, 45407, 53049, 60691anti-influenza_CDR 7198 14840, 22482, 30124, 37766, 45408, 53050, 60692anti-influenza_CDR 7199 14841, 22483, 30125, 37767, 45409, 53051, 60693anti-influenza_CDR 7200 14842, 22484, 30126, 37768, 45410, 53052, 60694anti-influenza_CDR 7201 14843, 22485, 30127, 37769, 45411, 53053, 60695anti-influenza_CDR 7202 14844, 22486, 30128, 37770, 45412, 53054, 60696anti-influenza_CDR 7203 14845, 22487, 30129, 37771, 45413, 53055, 60697anti-influenza_CDR 7204 14846, 22488, 30130, 37772, 45414, 53056, 60698anti-influenza_CDR 7205 14847, 22489, 30131, 37773, 45415, 53057, 60699anti-influenza_CDR 7206 14848, 22490, 30132, 37774, 45416, 53058, 60700anti-influenza_CDR 7207 14849, 22491, 30133, 37775, 45417, 53059, 60701anti-influenza_CDR 7208 14850, 22492, 30134, 37776, 45418, 53060, 60702anti-influenza_CDR 7209 14851, 22493, 30135, 37777, 45419, 53061, 60703anti-influenza_CDR 7210 14852, 22494, 30136, 37778, 45420, 53062, 60704anti-influenza_CDR 7211 14853, 22495, 30137, 37779, 45421, 53063, 60705anti-influenza_CDR 7212 14854, 22496, 30138, 37780, 45422, 53064, 60706anti-influenza_CDR 7213 14855, 22497, 30139, 37781, 45423, 53065, 60707anti-influenza_CDR 7214 14856, 22498, 30140, 37782, 45424, 53066, 60708anti-influenza_CDR 7215 14857, 22499, 30141, 37783, 45425, 53067, 60709anti-influenza_CDR 7216 14858, 22500, 30142, 37784, 45426, 53068, 60710anti-influenza_CDR 7217 14859, 22501, 30143, 37785, 45427, 53069, 60711anti-influenza_CDR 7218 14860, 22502, 30144, 37786, 45428, 53070, 60712anti-influenza_CDR 7219 14861, 22503, 30145, 37787, 45429, 53071, 60713anti-influenza_CDR 7220 14862, 22504, 30146, 37788, 45430, 53072, 60714anti-influenza_CDR 7221 14863, 22505, 30147, 37789, 45431, 53073, 60715anti-influenza_CDR 7222 14864, 22506, 30148, 37790, 45432, 53074, 60716anti-influenza_CDR 7223 14865, 22507, 30149, 37791, 45433, 53075, 60717anti-influenza_CDR 7224 14866, 22508, 30150, 37792, 45434, 53076, 60718anti-influenza_CDR 7225 14867, 22509, 30151, 37793, 45435, 53077, 60719anti-influenza_CDR 7226 14868, 22510, 30152, 37794, 45436, 53078, 60720anti-influenza_CDR 7227 14869, 22511, 30153, 37795, 45437, 53079, 60721anti-influenza_CDR 7228 14870, 22512, 30154, 37796, 45438, 53080, 60722anti-influenza_CDR 7229 14871, 22513, 30155, 37797, 45439, 53081, 60723anti-influenza_CDR 7230 14872, 22514, 30156, 37798, 45440, 53082, 60724anti-influenza_CDR 7231 14873, 22515, 30157, 37799, 45441, 53083, 60725anti-influenza_CDR 7232 14874, 22516, 30158, 37800, 45442, 53084, 60726anti-influenza_CDR 7233 14875, 22517, 30159, 37801, 45443, 53085, 60727anti-influenza_CDR 7234 14876, 22518, 30160, 37802, 45444, 53086, 60728anti-influenza_CDR 7235 14877, 22519, 30161, 37803, 45445, 53087, 60729anti-influenza_CDR 7236 14878, 22520, 30162, 37804, 45446, 53088, 60730anti-influenza_CDR 7237 14879, 22521, 30163, 37805, 45447, 53089, 60731anti-influenza_CDR 7238 14880, 22522, 30164, 37806, 45448, 53090, 60732anti-influenza_CDR 7239 14881, 22523, 30165, 37807, 45449, 53091, 60733anti-influenza_CDR 7240 14882, 22524, 30166, 37808, 45450, 53092, 60734anti-influenza_CDR 7241 14883, 22525, 30167, 37809, 45451, 53093, 60735anti-influenza_CDR 7242 14884, 22526, 30168, 37810, 45452, 53094, 60736anti-influenza_CDR 7243 14885, 22527, 30169, 37811, 45453, 53095, 60737anti-influenza_CDR 7244 14886, 22528, 30170, 37812, 45454, 53096, 60738anti-influenza_CDR 7245 14887, 22529, 30171, 37813, 45455, 53097, 60739anti-influenza_CDR 7246 14888, 22530, 30172, 37814, 45456, 53098, 60740anti-influenza_CDR 7247 14889, 22531, 30173, 37815, 45457, 53099, 60741anti-influenza_CDR 7248 14890, 22532, 30174, 37816, 45458, 53100, 60742anti-influenza_CDR 7249 14891, 22533, 30175, 37817, 45459, 53101, 60743anti-influenza_CDR 7250 14892, 22534, 30176, 37818, 45460, 53102, 60744anti-influenza_CDR 7251 14893, 22535, 30177, 37819, 45461, 53103, 60745anti-influenza_CDR 7252 14894, 22536, 30178, 37820, 45462, 53104, 60746anti-influenza_CDR 7253 14895, 22537, 30179, 37821, 45463, 53105, 60747anti-influenza_CDR 7254 14896, 22538, 30180, 37822, 45464, 53106, 60748anti-influenza_CDR 7255 14897, 22539, 30181, 37823, 45465, 53107, 60749anti-influenza_CDR 7256 14898, 22540, 30182, 37824, 45466, 53108, 60750anti-influenza_CDR 7257 14899, 22541, 30183, 37825, 45467, 53109, 60751anti-influenza_CDR 7258 14900, 22542, 30184, 37826, 45468, 53110, 60752anti-influenza_CDR 7259 14901, 22543, 30185, 37827, 45469, 53111, 60753anti-influenza_CDR 7260 14902, 22544, 30186, 37828, 45470, 53112, 60754anti-influenza_CDR 7261 14903, 22545, 30187, 37829, 45471, 53113, 60755anti-influenza_CDR 7262 14904, 22546, 30188, 37830, 45472, 53114, 60756anti-influenza_CDR 7263 14905, 22547, 30189, 37831, 45473, 53115, 60757anti-influenza_CDR 7264 14906, 22548, 30190, 37832, 45474, 53116, 60758anti-influenza_CDR 7265 14907, 22549, 30191, 37833, 45475, 53117, 60759anti-influenza_CDR 7266 14908, 22550, 30192, 37834, 45476, 53118, 60760anti-influenza_CDR 7267 14909, 22551, 30193, 37835, 45477, 53119, 60761anti-influenza_CDR 7268 14910, 22552, 30194, 37836, 45478, 53120, 60762anti-influenza_CDR 7269 14911, 22553, 30195, 37837, 45479, 53121, 60763anti-influenza_CDR 7270 14912, 22554, 30196, 37838, 45480, 53122, 60764anti-influenza_CDR 7271 14913, 22555, 30197, 37839, 45481, 53123, 60765anti-influenza_CDR 7272 14914, 22556, 30198, 37840, 45482, 53124, 60766anti-influenza_CDR 7273 14915, 22557, 30199, 37841, 45483, 53125, 60767anti-influenza_CDR 7274 14916, 22558, 30200, 37842, 45484, 53126, 60768anti-influenza_CDR 7275 14917, 22559, 30201, 37843, 45485, 53127, 60769anti-influenza_CDR 7276 14918, 22560, 30202, 37844, 45486, 53128, 60770anti-influenza_CDR 7277 14919, 22561, 30203, 37845, 45487, 53129, 60771anti-influenza_CDR 7278 14920, 22562, 30204, 37846, 45488, 53130, 60772anti-influenza_CDR 7279 14921, 22563, 30205, 37847, 45489, 53131, 60773anti-influenza_CDR 7280 14922, 22564, 30206, 37848, 45490, 53132, 60774anti-influenza_CDR 7281 14923, 22565, 30207, 37849, 45491, 53133, 60775anti-influenza_CDR 7282 14924, 22566, 30208, 37850, 45492, 53134, 60776anti-influenza_CDR 7283 14925, 22567, 30209, 37851, 45493, 53135, 60777anti-influenza_CDR 7284 14926, 22568, 30210, 37852, 45494, 53136, 60778anti-influenza_CDR 7285 14927, 22569, 30211, 37853, 45495, 53137, 60779anti-influenza_CDR 7286 14928, 22570, 30212, 37854, 45496, 53138, 60780anti-influenza_CDR 7287 14929, 22571, 30213, 37855, 45497, 53139, 60781anti-influenza_CDR 7288 14930, 22572, 30214, 37856, 45498, 53140, 60782anti-influenza_CDR 7289 14931, 22573, 30215, 37857, 45499, 53141, 60783anti-influenza_CDR 7290 14932, 22574, 30216, 37858, 45500, 53142, 60784anti-influenza_CDR 7291 14933, 22575, 30217, 37859, 45501, 53143, 60785anti-influenza_CDR 7292 14934, 22576, 30218, 37860, 45502, 53144, 60786anti-influenza_CDR 7293 14935, 22577, 30219, 37861, 45503, 53145, 60787anti-influenza_CDR 7294 14936, 22578, 30220, 37862, 45504, 53146, 60788anti-influenza_CDR 7295 14937, 22579, 30221, 37863, 45505, 53147, 60789anti-influenza_CDR 7296 14938, 22580, 30222, 37864, 45506, 53148, 60790anti-influenza_CDR 7297 14939, 22581, 30223, 37865, 45507, 53149, 60791anti-influenza_CDR 7298 14940, 22582, 30224, 37866, 45508, 53150, 60792anti-influenza_CDR 7299 14941, 22583, 30225, 37867, 45509, 53151, 60793anti-influenza_CDR 7300 14942, 22584, 30226, 37868, 45510, 53152, 60794anti-influenza_CDR 7301 14943, 22585, 30227, 37869, 45511, 53153, 60795anti-influenza_CDR 7302 14944, 22586, 30228, 37870, 45512, 53154, 60796anti-influenza_CDR 7303 14945, 22587, 30229, 37871, 45513, 53155, 60797anti-influenza_CDR 7304 14946, 22588, 30230, 37872, 45514, 53156, 60798anti-influenza_CDR 7305 14947, 22589, 30231, 37873, 45515, 53157, 60799anti-influenza_CDR 7306 14948, 22590, 30232, 37874, 45516, 53158, 60800anti-influenza_CDR 7307 14949, 22591, 30233, 37875, 45517, 53159, 60801anti-influenza_CDR 7308 14950, 22592, 30234, 37876, 45518, 53160, 60802anti-influenza_CDR 7309 14951, 22593, 30235, 37877, 45519, 53161, 60803anti-influenza_CDR 7310 14952, 22594, 30236, 37878, 45520, 53162, 60804anti-influenza_CDR 7311 14953, 22595, 30237, 37879, 45521, 53163, 60805anti-influenza_CDR 7312 14954, 22596, 30238, 37880, 45522, 53164, 60806anti-influenza_CDR 7313 14955, 22597, 30239, 37881, 45523, 53165, 60807anti-influenza_CDR 7314 14956, 22598, 30240, 37882, 45524, 53166, 60808anti-influenza_CDR 7315 14957, 22599, 30241, 37883, 45525, 53167, 60809anti-influenza_CDR 7316 14958, 22600, 30242, 37884, 45526, 53168, 60810anti-influenza_CDR 7317 14959, 22601, 30243, 37885, 45527, 53169, 60811anti-influenza_CDR 7318 14960, 22602, 30244, 37886, 45528, 53170, 60812anti-influenza_CDR 7319 14961, 22603, 30245, 37887, 45529, 53171, 60813anti-influenza_CDR 7320 14962, 22604, 30246, 37888, 45530, 53172, 60814anti-influenza_CDR 7321 14963, 22605, 30247, 37889, 45531, 53173, 60815anti-influenza_CDR 7322 14964, 22606, 30248, 37890, 45532, 53174, 60816anti-influenza_CDR 7323 14965, 22607, 30249, 37891, 45533, 53175, 60817anti-influenza_CDR 7324 14966, 22608, 30250, 37892, 45534, 53176, 60818anti-influenza_CDR 7325 14967, 22609, 30251, 37893, 45535, 53177, 60819anti-influenza_CDR 7326 14968, 22610, 30252, 37894, 45536, 53178, 60820anti-influenza_CDR 7327 14969, 22611, 30253, 37895, 45537, 53179, 60821anti-influenza_CDR 7328 14970, 22612, 30254, 37896, 45538, 53180, 60822anti-influenza_CDR 7329 14971, 22613, 30255, 37897, 45539, 53181, 60823anti-influenza_CDR 7330 14972, 22614, 30256, 37898, 45540, 53182, 60824anti-influenza_CDR 7331 14973, 22615, 30257, 37899, 45541, 53183, 60825anti-influenza_CDR 7332 14974, 22616, 30258, 37900, 45542, 53184, 60826anti-influenza_CDR 7333 14975, 22617, 30259, 37901, 45543, 53185, 60827anti-influenza_CDR 7334 14976, 22618, 30260, 37902, 45544, 53186, 60828anti-influenza_CDR 7335 14977, 22619, 30261, 37903, 45545, 53187, 60829anti-influenza_CDR 7336 14978, 22620, 30262, 37904, 45546, 53188, 60830anti-influenza_CDR 7337 14979, 22621, 30263, 37905, 45547, 53189, 60831anti-influenza_CDR 7338 14980, 22622, 30264, 37906, 45548, 53190, 60832anti-influenza_CDR 7339 14981, 22623, 30265, 37907, 45549, 53191, 60833anti-influenza_CDR 7340 14982, 22624, 30266, 37908, 45550, 53192, 60834anti-influenza_CDR 7341 14983, 22625, 30267, 37909, 45551, 53193, 60835anti-influenza_CDR 7342 14984, 22626, 30268, 37910, 45552, 53194, 60836anti-influenza_CDR 7343 14985, 22627, 30269, 37911, 45553, 53195, 60837anti-influenza_CDR 7344 14986, 22628, 30270, 37912, 45554, 53196, 60838anti-influenza_CDR 7345 14987, 22629, 30271, 37913, 45555, 53197, 60839anti-influenza_CDR 7346 14988, 22630, 30272, 37914, 45556, 53198, 60840anti-influenza_CDR 7347 14989, 22631, 30273, 37915, 45557, 53199, 60841anti-influenza_CDR 7348 14990, 22632, 30274, 37916, 45558, 53200, 60842anti-influenza_CDR 7349 14991, 22633, 30275, 37917, 45559, 53201, 60843anti-influenza_CDR 7350 14992, 22634, 30276, 37918, 45560, 53202, 60844anti-influenza_CDR 7351 14993, 22635, 30277, 37919, 45561, 53203, 60845anti-influenza_CDR 7352 14994, 22636, 30278, 37920, 45562, 53204, 60846anti-influenza_CDR 7353 14995, 22637, 30279, 37921, 45563, 53205, 60847anti-influenza_CDR 7354 14996, 22638, 30280, 37922, 45564, 53206, 60848anti-influenza_CDR 7355 14997, 22639, 30281, 37923, 45565, 53207, 60849anti-influenza_CDR 7356 14998, 22640, 30282, 37924, 45566, 53208, 60850anti-influenza_CDR 7357 14999, 22641, 30283, 37925, 45567, 53209, 60851anti-influenza_CDR 7358 15000, 22642, 30284, 37926, 45568, 53210, 60852anti-influenza_CDR 7359 15001, 22643, 30285, 37927, 45569, 53211, 60853anti-influenza_CDR 7360 15002, 22644, 30286, 37928, 45570, 53212, 60854anti-influenza_CDR 7361 15003, 22645, 30287, 37929, 45571, 53213, 60855anti-influenza_CDR 7362 15004, 22646, 30288, 37930, 45572, 53214, 60856anti-influenza_CDR 7363 15005, 22647, 30289, 37931, 45573, 53215, 60857anti-influenza_CDR 7364 15006, 22648, 30290, 37932, 45574, 53216, 60858anti-influenza_CDR 7365 15007, 22649, 30291, 37933, 45575, 53217, 60859anti-influenza_CDR 7366 15008, 22650, 30292, 37934, 45576, 53218, 60860anti-influenza_CDR 7367 15009, 22651, 30293, 37935, 45577, 53219, 60861anti-influenza_CDR 7368 15010, 22652, 30294, 37936, 45578, 53220, 60862anti-influenza_CDR 7369 15011, 22653, 30295, 37937, 45579, 53221, 60863anti-influenza_CDR 7370 15012, 22654, 30296, 37938, 45580, 53222, 60864anti-influenza_CDR 7371 15013, 22655, 30297, 37939, 45581, 53223, 60865anti-influenza_CDR 7372 15014, 22656, 30298, 37940, 45582, 53224, 60866anti-influenza_CDR 7373 15015, 22657, 30299, 37941, 45583, 53225, 60867anti-influenza_CDR 7374 15016, 22658, 30300, 37942, 45584, 53226, 60868anti-influenza_CDR 7375 15017, 22659, 30301, 37943, 45585, 53227, 60869anti-influenza_CDR 7376 15018, 22660, 30302, 37944, 45586, 53228, 60870anti-influenza_CDR 7377 15019, 22661, 30303, 37945, 45587, 53229, 60871anti-influenza_CDR 7378 15020, 22662, 30304, 37946, 45588, 53230, 60872anti-influenza_CDR 7379 15021, 22663, 30305, 37947, 45589, 53231, 60873anti-influenza_CDR 7380 15022, 22664, 30306, 37948, 45590, 53232, 60874anti-influenza_CDR 7381 15023, 22665, 30307, 37949, 45591, 53233, 60875anti-influenza_CDR 7382 15024, 22666, 30308, 37950, 45592, 53234, 60876anti-influenza_CDR 7383 15025, 22667, 30309, 37951, 45593, 53235, 60877anti-influenza_CDR 7384 15026, 22668, 30310, 37952, 45594, 53236, 60878anti-influenza_CDR 7385 15027, 22669, 30311, 37953, 45595, 53237, 60879anti-influenza_CDR 7386 15028, 22670, 30312, 37954, 45596, 53238, 60880anti-influenza_CDR 7387 15029, 22671, 30313, 37955, 45597, 53239, 60881anti-influenza_CDR 7388 15030, 22672, 30314, 37956, 45598, 53240, 60882anti-influenza_CDR 7389 15031, 22673, 30315, 37957, 45599, 53241, 60883anti-influenza_CDR 7390 15032, 22674, 30316, 37958, 45600, 53242, 60884anti-influenza_CDR 7391 15033, 22675, 30317, 37959, 45601, 53243, 60885anti-influenza_CDR 7392 15034, 22676, 30318, 37960, 45602, 53244, 60886anti-influenza_CDR 7393 15035, 22677, 30319, 37961, 45603, 53245, 60887anti-influenza_CDR 7394 15036, 22678, 30320, 37962, 45604, 53246, 60888anti-influenza_CDR 7395 15037, 22679, 30321, 37963, 45605, 53247, 60889anti-influenza_CDR 7396 15038, 22680, 30322, 37964, 45606, 53248, 60890anti-influenza_CDR 7397 15039, 22681, 30323, 37965, 45607, 53249, 60891anti-influenza_CDR 7398 15040, 22682, 30324, 37966, 45608, 53250, 60892anti-influenza_CDR 7399 15041, 22683, 30325, 37967, 45609, 53251, 60893anti-influenza_CDR 7400 15042, 22684, 30326, 37968, 45610, 53252, 60894anti-influenza_CDR 7401 15043, 22685, 30327, 37969, 45611, 53253, 60895anti-influenza_CDR 7402 15044, 22686, 30328, 37970, 45612, 53254, 60896anti-influenza_CDR 7403 15045, 22687, 30329, 37971, 45613, 53255, 60897anti-influenza_CDR 7404 15046, 22688, 30330, 37972, 45614, 53256, 60898anti-influenza_CDR 7405 15047, 22689, 30331, 37973, 45615, 53257, 60899anti-influenza_CDR 7406 15048, 22690, 30332, 37974, 45616, 53258, 60900anti-influenza_CDR 7407 15049, 22691, 30333, 37975, 45617, 53259, 60901anti-influenza_CDR 7408 15050, 22692, 30334, 37976, 45618, 53260, 60902anti-influenza_CDR 7409 15051, 22693, 30335, 37977, 45619, 53261, 60903anti-influenza_CDR 7410 15052, 22694, 30336, 37978, 45620, 53262, 60904anti-influenza_CDR 7411 15053, 22695, 30337, 37979, 45621, 53263, 60905anti-influenza_CDR 7412 15054, 22696, 30338, 37980, 45622, 53264, 60906anti-influenza_CDR 7413 15055, 22697, 30339, 37981, 45623, 53265, 60907anti-influenza_CDR 7414 15056, 22698, 30340, 37982, 45624, 53266, 60908anti-influenza_CDR 7415 15057, 22699, 30341, 37983, 45625, 53267, 60909anti-influenza_CDR 7416 15058, 22700, 30342, 37984, 45626, 53268, 60910anti-influenza_CDR 7417 15059, 22701, 30343, 37985, 45627, 53269, 60911anti-influenza_CDR 7418 15060, 22702, 30344, 37986, 45628, 53270, 60912anti-influenza_CDR 7419 15061, 22703, 30345, 37987, 45629, 53271, 60913anti-influenza_CDR 7420 15062, 22704, 30346, 37988, 45630, 53272, 60914anti-influenza_CDR 7421 15063, 22705, 30347, 37989, 45631, 53273, 60915anti-influenza_CDR 7422 15064, 22706, 30348, 37990, 45632, 53274, 60916anti-influenza_CDR 7423 15065, 22707, 30349, 37991, 45633, 53275, 60917anti-influenza_CDR 7424 15066, 22708, 30350, 37992, 45634, 53276, 60918anti-influenza_CDR 7425 15067, 22709, 30351, 37993, 45635, 53277, 60919anti-influenza_CDR 7426 15068, 22710, 30352, 37994, 45636, 53278, 60920anti-influenza_CDR 7427 15069, 22711, 30353, 37995, 45637, 53279, 60921anti-influenza_CDR 7428 15070, 22712, 30354, 37996, 45638, 53280, 60922anti-influenza_CDR 7429 15071, 22713, 30355, 37997, 45639, 53281, 60923anti-influenza_CDR 7430 15072, 22714, 30356, 37998, 45640, 53282, 60924anti-influenza_CDR 7431 15073, 22715, 30357, 37999, 45641, 53283, 60925anti-influenza_CDR 7432 15074, 22716, 30358, 38000, 45642, 53284, 60926anti-influenza_CDR 7433 15075, 22717, 30359, 38001, 45643, 53285, 60927anti-influenza_CDR 7434 15076, 22718, 30360, 38002, 45644, 53286, 60928anti-influenza_CDR 7435 15077, 22719, 30361, 38003, 45645, 53287, 60929anti-influenza_CDR 7436 15078, 22720, 30362, 38004, 45646, 53288, 60930anti-influenza_CDR 7437 15079, 22721, 30363, 38005, 45647, 53289, 60931anti-influenza_CDR 7438 15080, 22722, 30364, 38006, 45648, 53290, 60932anti-influenza_CDR 7439 15081, 22723, 30365, 38007, 45649, 53291, 60933anti-influenza_CDR 7440 15082, 22724, 30366, 38008, 45650, 53292, 60934anti-influenza_CDR 7441 15083, 22725, 30367, 38009, 45651, 53293, 60935anti-influenza_CDR 7442 15084, 22726, 30368, 38010, 45652, 53294, 60936anti-influenza_CDR 7443 15085, 22727, 30369, 38011, 45653, 53295, 60937anti-influenza_CDR 7444 15086, 22728, 30370, 38012, 45654, 53296, 60938anti-influenza_CDR 7445 15087, 22729, 30371, 38013, 45655, 53297, 60939anti-influenza_CDR 7446 15088, 22730, 30372, 38014, 45656, 53298, 60940anti-influenza_CDR 7447 15089, 22731, 30373, 38015, 45657, 53299, 60941anti-influenza_CDR 7448 15090, 22732, 30374, 38016, 45658, 53300, 60942anti-influenza_CDR 7449 15091, 22733, 30375, 38017, 45659, 53301, 60943anti-influenza_CDR 7450 15092, 22734, 30376, 38018, 45660, 53302, 60944anti-influenza_CDR 7451 15093, 22735, 30377, 38019, 45661, 53303, 60945anti-influenza_CDR 7452 15094, 22736, 30378, 38020, 45662, 53304, 60946anti-influenza_CDR 7453 15095, 22737, 30379, 38021, 45663, 53305, 60947anti-influenza_CDR 7454 15096, 22738, 30380, 38022, 45664, 53306, 60948anti-influenza_CDR 7455 15097, 22739, 30381, 38023, 45665, 53307, 60949anti-influenza_CDR 7456 15098, 22740, 30382, 38024, 45666, 53308, 60950anti-influenza_CDR 7457 15099, 22741, 30383, 38025, 45667, 53309, 60951anti-influenza_CDR 7458 15100, 22742, 30384, 38026, 45668, 53310, 60952anti-influenza_CDR 7459 15101, 22743, 30385, 38027, 45669, 53311, 60953anti-influenza_CDR 7460 15102, 22744, 30386, 38028, 45670, 53312, 60954anti-influenza_CDR 7461 15103, 22745, 30387, 38029, 45671, 53313, 60955anti-influenza_CDR 7462 15104, 22746, 30388, 38030, 45672, 53314, 60956anti-influenza_CDR 7463 15105, 22747, 30389, 38031, 45673, 53315, 60957anti-influenza_CDR 7464 15106, 22748, 30390, 38032, 45674, 53316, 60958anti-influenza_CDR 7465 15107, 22749, 30391, 38033, 45675, 53317, 60959anti-influenza_CDR 7466 15108, 22750, 30392, 38034, 45676, 53318, 60960anti-influenza_CDR 7467 15109, 22751, 30393, 38035, 45677, 53319, 60961anti-influenza_CDR 7468 15110, 22752, 30394, 38036, 45678, 53320, 60962anti-influenza_CDR 7469 15111, 22753, 30395, 38037, 45679, 53321, 60963anti-influenza_CDR 7470 15112, 22754, 30396, 38038, 45680, 53322, 60964anti-influenza_CDR 7471 15113, 22755, 30397, 38039, 45681, 53323, 60965anti-influenza_CDR 7472 15114, 22756, 30398, 38040, 45682, 53324, 60966anti-influenza_CDR 7473 15115, 22757, 30399, 38041, 45683, 53325, 60967anti-influenza_CDR 7474 15116, 22758, 30400, 38042, 45684, 53326, 60968anti-influenza_CDR 7475 15117, 22759, 30401, 38043, 45685, 53327, 60969anti-influenza_CDR 7476 15118, 22760, 30402, 38044, 45686, 53328, 60970anti-influenza_CDR 7477 15119, 22761, 30403, 38045, 45687, 53329, 60971anti-influenza_CDR 7478 15120, 22762, 30404, 38046, 45688, 53330, 60972anti-influenza_CDR 7479 15121, 22763, 30405, 38047, 45689, 53331, 60973anti-influenza_CDR 7480 15122, 22764, 30406, 38048, 45690, 53332, 60974anti-influenza_CDR 7481 15123, 22765, 30407, 38049, 45691, 53333, 60975anti-influenza_CDR 7482 15124, 22766, 30408, 38050, 45692, 53334, 60976anti-influenza_CDR 7483 15125, 22767, 30409, 38051, 45693, 53335, 60977anti-influenza_CDR 7484 15126, 22768, 30410, 38052, 45694, 53336, 60978anti-influenza_CDR 7485 15127, 22769, 30411, 38053, 45695, 53337, 60979anti-influenza_CDR 7486 15128, 22770, 30412, 38054, 45696, 53338, 60980anti-influenza_CDR 7487 15129, 22771, 30413, 38055, 45697, 53339, 60981anti-influenza_CDR 7488 15130, 22772, 30414, 38056, 45698, 53340, 60982anti-influenza_CDR 7489 15131, 22773, 30415, 38057, 45699, 53341, 60983anti-influenza_CDR 7490 15132, 22774, 30416, 38058, 45700, 53342, 60984anti-influenza_CDR 7491 15133, 22775, 30417, 38059, 45701, 53343, 60985anti-influenza_CDR 7492 15134, 22776, 30418, 38060, 45702, 53344, 60986anti-influenza_CDR 7493 15135, 22777, 30419, 38061, 45703, 53345, 60987anti-influenza_CDR 7494 15136, 22778, 30420, 38062, 45704, 53346, 60988anti-influenza_CDR 7495 15137, 22779, 30421, 38063, 45705, 53347, 60989anti-influenza_CDR 7496 15138, 22780, 30422, 38064, 45706, 53348, 60990anti-influenza_CDR 7497 15139, 22781, 30423, 38065, 45707, 53349, 60991anti-influenza_CDR 7498 15140, 22782, 30424, 38066, 45708, 53350, 60992anti-influenza_CDR 7499 15141, 22783, 30425, 38067, 45709, 53351, 60993anti-influenza_CDR 7500 15142, 22784, 30426, 38068, 45710, 53352, 60994anti-influenza_CDR 7501 15143, 22785, 30427, 38069, 45711, 53353, 60995anti-influenza_CDR 7502 15144, 22786, 30428, 38070, 45712, 53354, 60996anti-influenza_CDR 7503 15145, 22787, 30429, 38071, 45713, 53355, 60997anti-influenza_CDR 7504 15146, 22788, 30430, 38072, 45714, 53356, 60998anti-influenza_CDR 7505 15147, 22789, 30431, 38073, 45715, 53357, 60999anti-influenza_CDR 7506 15148, 22790, 30432, 38074, 45716, 53358, 61000anti-influenza_CDR 7507 15149, 22791, 30433, 38075, 45717, 53359, 61001anti-influenza_CDR 7508 15150, 22792, 30434, 38076, 45718, 53360, 61002anti-influenza_CDR 7509 15151, 22793, 30435, 38077, 45719, 53361, 61003anti-influenza_CDR 7510 15152, 22794, 30436, 38078, 45720, 53362, 61004anti-influenza_CDR 7511 15153, 22795, 30437, 38079, 45721, 53363, 61005anti-influenza_CDR 7512 15154, 22796, 30438, 38080, 45722, 53364, 61006anti-influenza_CDR 7513 15155, 22797, 30439, 38081, 45723, 53365, 61007anti-influenza_CDR 7514 15156, 22798, 30440, 38082, 45724, 53366, 61008anti-influenza_CDR 7515 15157, 22799, 30441, 38083, 45725, 53367, 61009anti-influenza_CDR 7516 15158, 22800, 30442, 38084, 45726, 53368, 61010anti-influenza_CDR 7517 15159, 22801, 30443, 38085, 45727, 53369, 61011anti-influenza_CDR 7518 15160, 22802, 30444, 38086, 45728, 53370, 61012anti-influenza_CDR 7519 15161, 22803, 30445, 38087, 45729, 53371, 61013anti-influenza_CDR 7520 15162, 22804, 30446, 38088, 45730, 53372, 61014anti-influenza_CDR 7521 15163, 22805, 30447, 38089, 45731, 53373, 61015anti-influenza_CDR 7522 15164, 22806, 30448, 38090, 45732, 53374, 61016anti-influenza_CDR 7523 15165, 22807, 30449, 38091, 45733, 53375, 61017anti-influenza_CDR 7524 15166, 22808, 30450, 38092, 45734, 53376, 61018anti-0X40_HeavyChain_CDR1 7525 15167, 22809, 30451, 38093, 45735, 53377,61019 anti-0X40_HeavyChain_CDR1 7526 15168, 22810, 30452, 38094, 45736,53378, 61020 anti-0X40_HeavyChain_CDR1 7527 15169, 22811, 30453, 38095,45737, 53379, 61021 anti-0X40_HeavyChain_CDR1 7528 15170, 22812, 30454,38096, 45738, 53380, 61022 anti-0X40_HeavyChain_CDR1 7529 15171, 22813,30455, 38097, 45739, 53381, 61023 anti-0X40_HeavyChain_CDR1 7530 15172,22814, 30456, 38098, 45740, 53382, 61024 anti-0X40_LightChain_CDR2 753115173, 22815, 30457, 38099, 45741, 53383, 61025anti-0X40_LightChain_CDR2 7532 15174, 22816, 30458, 38100, 45742, 53384,61026 anti-0X40_LightChain_CDR2 7533 15175, 22817, 30459, 38101, 45743,53385, 61027 anti-0X40_LightChain_CDR2 7534 15176, 22818, 30460, 38102,45744, 53386, 61028 anti-0X40_LightChain_CDR3 7535 15177, 22819, 30461,38103, 45745, 53387, 61029 anti-0X40_HeavyChain_CDR3 7536 15178, 22820,30462, 38104, 45746, 53388, 61030 anti-0X40_HeavyChain_CDR3 7537 15179,22821, 30463, 38105, 45747, 53389, 61031 anti-0X40_HeavyChain_CDR3 753815180, 22822, 30464, 38106, 45748, 53390, 61032anti-0X40_LightChain_CDR3 7539 15181, 22823, 30465, 38107, 45749, 53391,61033 anti-0X40_HeavyChain_CDR3 7540 15182, 22824, 30466, 38108, 45750,53392, 61034 anti-0X40_LightChain_CDR3 7541 15183, 22825, 30467, 38109,45751, 53393, 61035 anti-0X40_LightChain_CDR3 7542 15184, 22826, 30468,38110, 45752, 53394, 61036 anti-0X40_LightChain_CDR3 7543 15185, 22827,30469, 38111, 45753, 53395, 61037 anti-0X40_LightChain_CDR3 7544 15186,22828, 30470, 38112, 45754, 53396, 61038 anti-0X40_LightChain_CDR3 754515187, 22829, 30471, 38113, 45755, 53397, 61039anti-0X40_LightChain_CDR3 7546 15188, 22830, 30472, 38114, 45756, 53398,61040 anti-0X40_LightChain_CDR3 7547 15189, 22831, 30473, 38115, 45757,53399, 61041 anti-0X40_LightChain_CDR3 7548 15190, 22832, 30474, 38116,45758, 53400, 61042 anti-0X40_LightChain_CDR3 7549 15191, 22833, 30475,38117, 45759, 53401, 61043 anti-0X40_HeavyChain_CDR1 7550 15192, 22834,30476, 38118, 45760, 53402, 61044 anti-0X40_HeavyChain_CDR3 7551 15193,22835, 30477, 38119, 45761, 53403, 61045 anti-0X40_LightChain_CDR1 755215194, 22836, 30478, 38120, 45762, 53404, 61046anti-0X40_LightChain_CDR1 7553 15195, 22837, 30479, 38121, 45763, 53405,61047 anti-0X40_LightChain_CDR1 7554 15196, 22838, 30480, 38122, 45764,53406, 61048 anti-0X40_HeavyChain_CDR3 7555 15197, 22839, 30481, 38123,45765, 53407, 61049 anti-0X40_HeavyChain_CDR3 7556 15198, 22840, 30482,38124, 45766, 53408, 61050 anti-0X40_HeavyChain_CDR3 7557 15199, 22841,30483, 38125, 45767, 53409, 61051 anti-0X40_HeavyChain_CDR3 7558 15200,22842, 30484, 38126, 45768, 53410, 61052 anti-0X40_HeavyChain_CDR2 755915201, 22843, 30485, 38127, 45769, 53411, 61053anti-0X40_HeavyChain_CDR2 7560 15202, 22844, 30486, 38128, 45770, 53412,61054 anti-0X40_HeavyChain_CDR2 7561 15203, 22845, 30487, 38129, 45771,53413, 61055 anti-0X40_HeavyChain_CDR2 7562 15204, 22846, 30488, 38130,45772, 53414, 61056 anti-0X40_HeavyChain_CDR2 7563 15205, 22847, 30489,38131, 45773, 53415, 61057 anti-0X40_HeavyChain_CDR2 7564 15206, 22848,30490, 38132, 45774, 53416, 61058 anti-0X40_HeavyChain_CDR2 7565 15207,22849, 30491, 38133, 45775, 53417, 61059 anti-0X40_HeavyChain_CDR2 756615208, 22850, 30492, 38134, 45776, 53418, 61060anti-0X40_HeavyChain_CDR2 7567 15209, 22851, 30493, 38135, 45777, 53419,61061 anti-0X40_HeavyChain_CDR2 7568 15210, 22852, 30494, 38136, 45778,53420, 61062 anti-0X40_HeavyChain_CDR2 7569 15211, 22853, 30495, 38137,45779, 53421, 61063 anti-0X40_HeavyChain_CDR2 7570 15212, 22854, 30496,38138, 45780, 53422, 61064

Accordingly, it is preferred that the CDR encoded by the at least onecoding sequence comprises or consists of an amino acid sequence as setforth in any of SEQ ID NOs: 5601-7570. It is also preferred that the atleast one coding sequence comprises or consists of a nucleic acidsequence as set forth in any of SEQ ID NOs: 13243-15212, 20885-22854,28527-30496, 36169-38138, 43811-45780, 51453-53422, and 59095-61064.

The amino acid sequences of exemplary CDRs comprising less than 4 aminoacids are shown below in Table 7.

TABLE 7 Amino acid sequences and corresponding SEQ ID NOs of exemplaryCDRs comprising less than 4 amino acids Amino Acid Sequence SEQ ID NO AR6478 AK 6479 SNN 6480 VAS 6481 ATY 6482 TAY 6483 DND 6484 HGT 6485 DVS6486 DTD 6487 GAS 6488 KAS 6489 DDS 6490 AAS 6491 SAS 6492 LGS 6493 WAS6494 EDS 6495 DDD 6496 TDN 6497 LAS 6498 DAS 6499 EVR 6500 DDR 6501 AAI6502 RAS 6503

The nucleic acid (RNA) sequences of exemplary CDRs comprising less than10 nucleotides are shown below in Table 8.

TABLE 8 RNA sequences and corresponding SEQ ID NOs of exemplary CDRscomprising less than 10 nucleotides RNA Sequence SEQ ID NO GCCCGC 14120GCCAAG 14121 AGCAACAAC 14122 GUGGCCAGC 14123 GCCACCUAC 14124 ACCGCCUAC14125 GACAACGAC 14126 CACGGCACC 14127 GACGUGAGC 14128 GACACCGAC 14129GGCGCCAGC 14130 AAGGCCAGC 14131 GACGACAGC 14132 GCCGCCAGC 14133AGCGCCUCC 14134 CUGGGCAGC 14135 UGGGCCAGC 14136 GAGGACAGC 14137CAGGACGAC 14138 ACCGACAAC 14139 CUGGCCAGC 14140 GACGCCAGC 14141GAGGUGCGC 14142 GACGACCGC 14143 GCCGCCAUC 14144 CGCGCCAGC 14145 GCCCGC21762 GCCAAG 21763 UCCAACAAC 21764 GUCGCCUCC 21765 GCCACCUAC 21766ACCGCCUAC 21767 GACAACGAC 21768 CACGGCACC 21769 GACGUCUCC 21770GACACCGAC 21771 GGCGCCUCC 21772 AAGGCCUCC 21773 GACGACUCC 21774GCCGCCUCC 21775 UCCGCCUCC 21776 CUCGGCUCC 21777 UGGGCCUCC 21778GAGGACUCC 21779 CAGGACGAC 21780 ACCGACAAC 21781 CUCGCCUCC 21782GACGCCUCC 21783 GAGGUCCGC 21784 GACGACCGC 21785 GCCGCCAUC 21786CGCGCCUCC 21787 GCCAGA 29404 GCCAAG 29405 AGCAACAAU 29406 GUGGCCAGC29407 GCCACCUAC 29408 ACCGCCUAC 29409 GACAACGAU 29410 CACGGCACC 29411GACGUGAGC 29412 GACACCGAU 29413 GGCGCCAGC 29414 AAGGCCAGC 29415GACGAUAGC 29416 GCCGCUAGC 29417 AGCGCCUCC 29418 CUGGGCAGC 29419UGGGCCAGC 29420 GAGGACAGC 29421 CAGGACGAU 29422 ACCGACAAC 29423CUGGCCAGC 29424 GACGCCAGC 29425 GAGGUGAGA 29426 GACGAUAGA 29427GCCGCUAUC 29428 AGAGCCAGC 29429 GCCAGA 37046 GCCAAG 37047 AGCAACAAC37048 GUGGCCAGC 37049 GCCACCUAC 37050 ACCGCCUAC 37051 GACAACGAC 37052CACGGCACC 37053 GACGUGAGC 37054 GACACCGAC 37055 GGCGCCAGC 37056AAGGCCAGC 37057 GACGACAGC 37058 GCCGCCAGC 37059 AGCGCCAGC 37060CUGGGCAGC 37061 UGGGCCAGC 37062 GAGGACAGC 37063 CAGGACGAC 37064ACCGACAAC 37065 CUGGCCAGC 37066 GACGCCAGC 37067 GAGGUGAGA 37068GACGACAGA 37069 GCCGCCAUC 37070 AGAGCCAGC 37071 GCCAGA 44688 GCCAAG44689 AGCAACAAU 44690 GUGGCCAGC 44691 GCCACCUAC 44692 ACCGCCUAC 44693GACAACGAU 44694 CACGGCACC 44695 GACGUGAGC 44696 GACACCGAU 44697GGCGCCAGC 44698 AAGGCCAGC 44699 GACGAUAGC 44700 GCCGCUAGC 44701AGCGCCUCC 44702 CUGGGCAGC 44703 UGGGCCAGC 44704 GAGGACAGC 44705CAGGACGAU 44706 ACCGACAAC 44707 CUGGCCAGC 44708 GACGCCAGC 44709GAGGUGAGA 44710 GACGAUAGA 44711 GCCGCUAUC 44712 AGAGCCAGC 44713 GCGCGA52330 GCCAAG 52331 AGCAAUAAC 52332 GUCGCUAGU 52333 GCCACAUAU 52334ACCGCCUAC 52335 GAUAACGAU 52336 CACGGCACC 52337 GACGUAAGU 52338GAUACAGAU 52339 GGCGCGAGU 52340 AAAGCCAGC 52341 GACGACAGU 52342GCCGCUUCA 52343 AGCGCGAGC 52344 CUAGGCAGC 52345 UGGGCAAGU 52346GAGGACAGU 52347 CAAGACGAC 52348 ACCGACAAC 52349 CUCGCUAGC 52350GACGCCAGU 52351 GAGGUGAGA 52352 GACGAUAGA 52353 GCGGCUAUA 52354CGCGCGAGC 52355 GCGCGG 59972 GCGAAG 59973 UCCAACAAC 59974 GUCGCCAGU59975 GCCACCUAU 59976 ACCGCCUAC 59977 GAUAACGAU 59978 CACGGCACC 59979GACGUGAGU 59980 GAUACCGAU 59981 GGCGCGAGU 59982 AAAGCGAGC 59983GACGACAGU 59984 GCCGCCUCA 59985 AGCGCAAGU 59986 CUCGGCAGC 59987UGGGCGAGU 59988 GAGGACAGU 59989 CAAGACGAC 59990 ACCGACAAC 59991CUCGCCAGC 59992 GACGCGAGU 59993 GAGGUCAGG 59994 GACGACAGA 59995GCGGCCAUA 59996 CGCGCGAGC 59997

Preferably, the RNA according to the present invention comprises codingsequences encoding at least two CDRs of an antibody, more preferably atleast three CDRs of an antibody, even more preferably at least four CDRsof an antibody, still more preferably at least five CDRs of an antibody,and most preferably six CDRs of an antibody.

It is also preferred that the at least one coding sequence of the RNAaccording to the present invention encodes a constant region of anantibody or a fragment or variant of constant region of an antibody.Typically, the constant region is identical in all antibodies of thesame isotype, but differs in antibodies of different isotypes. Heavychains γ, α and δ have a constant region composed of three tandem (in aline) immunoglobulin domains, and a hinge region for added flexibility;heavy chains μ and ε have a constant region composed of fourimmunoglobulin domains.

Preferably, the at least one coding sequence of the RNA according to thepresent invention encodes a heavy chain constant region of an antibodyor a fragment or variant of heavy chain constant region of an antibody.It is also preferred that the at least one coding sequence encodes alight chain constant region of an antibody or a fragment or variant oflight chain constant region of an antibody.

It is also preferred that the constant region encoded by the at leastone coding sequence comprises or consists of an amino acid sequence asdescribed in Table 9 below (referred to as “protein SEQ ID NO”).Particularly preferably, the at least one coding sequence comprises orconsists of a nucleic acid sequence (RNA sequence) as described in Table9 below (referred to as “RNA SEQ ID NO”).

TABLE 9 Overview over the SEQ ID NOs of the amino acid sequences ofpreferred exemplary constant regions and of the respective encoding RNAsequences. Name Protein SEQ ID NO: RNA SEQ ID NO:Ig_LightChain_kappa_constant_domain 7571 15213, 22855, 30497, 38139,45781, 53423, 61065 Ig_LightChain_kappa_constant_domain 7572 15214,22856, 30498, 38140, 45782, 53424, 61066Ig_LightChain_lambda_constant_domain 7573 15215, 22857, 30499, 38141,45783, 53425, 61067 Ig_LightChain_lambda_constant_domain 7574 15216,22858, 30500, 38142, 45784, 53426, 61068Ig_LightChain_lambda_constant_domain 7575 15217, 22859, 30501, 38143,45785, 53427, 61069 Ig_LightChain_lambda_constant_domain 7576 15218,22860, 30502, 38144, 45786, 53428, 61070IgG1_HeavyChain_CH1_constant_domain 7577 15219, 22861, 30503, 38145,45787, 53429, 61071 IgG1_HeavyChain_CH1_constant_domain 7578 15220,22862, 30504, 38146, 45788, 53430, 61072IgG1_HeavyChain_CH1_constant_domain 7579 15221, 22863, 30505, 38147,45789, 53431, 61073 IgG1_HeavyChain_CH1_constant_domain 7580 15222,22864, 30506, 38148, 45790, 53432, 61074IgG1_HeavyChain_CH1_constant_domain 7581 15223, 22865, 30507, 38149,45791, 53433, 61075 IgG1_HeavyChain_CH1_constant_domain 7582 15224,22866, 30508, 38150, 45792, 53434, 61076IgG1_HeavyChain_CH1_constant_domain 7583 15225, 22867, 30509, 38151,45793, 53435, 61077 IgG1_HeavyChain_CH1_constant_domain 7584 15226,22868, 30510, 38152, 45794, 53436, 61078IgG1_HeavyChain_CH1_constant_domain 7585 15227, 22869, 30511, 38153,45795, 53437, 61079 IgG1_HeavyChain_CH1_constant_domain 7586 15228,22870, 30512, 38154, 45796, 53438, 61080IgG1_HeavyChain_CH1_constant_domain 7587 15229, 22871, 30513, 38155,45797, 53439, 61081 IgG1_HeavyChain_CH1_constant_domain 7588 15230,22872, 30514, 38156, 45798, 53440, 61082IgG1_HeavyChain_CH1_constant_domain 7589 15231, 22873, 30515, 38157,45799, 53441, 61083 IgG1_HeavyChain_CH1_constant_domain 7590 15232,22874, 30516, 38158, 45800, 53442, 61084IgG1_HeavyChain_CH1_constant_domain 7591 15233, 22875, 30517, 38159,45801, 53443, 61085 IgG1_HeavyChain_CH1_constant_domain 7592 15234,22876, 30518, 38160, 45802, 53444, 61086IgG1_HeavyChain_CH2_constant_domain 7593 15235, 22877, 30519, 38161,45803, 53445, 61087 IgG1_HeavyChain_CH2_constant_domain 7594 15236,22878, 30520, 38162, 45804, 53446, 61088IgG1_HeavyChain_CH2_constant_domain 7595 15237, 22879, 30521, 38163,45805, 53447, 61089 IgG1_HeavyChain_CH2_constant_domain 7596 15238,22880, 30522, 38164, 45806, 53448, 61090IgG1_HeavyChain_CH2_constant_domain 7597 15239, 22881, 30523, 38165,45807, 53449, 61091 IgG1_HeavyChain_CH2_constant_domain 7598 15240,22882, 30524, 38166, 45808, 53450, 61092IgG1_HeavyChain_CH2_constant_domain 7599 15241, 22883, 30525, 38167,45809, 53451, 61093 IgG1_HeavyChain_CH2_constant_domain 7600 15242,22884, 30526, 38168, 45810, 53452, 61094IgG1_HeavyChain_CH2_constant_domain 7601 15243, 22885, 30527, 38169,45811, 53453, 61095 IgG1_HeavyChain_CH2_constant_domain 7602 15244,22886, 30528, 38170, 45812, 53454, 61096IgG1_HeavyChain_CH2_constant_domain 7603 15245, 22887, 30529, 38171,45813, 53455, 61097 IgG1_HeavyChain_CH2_constant_domain 7604 15246,22888, 30530, 38172, 45814, 53456, 61098IgG1_HeavyChain_CH2_constant_domain 7605 15247, 22889, 30531, 38173,45815, 53457, 61099 IgG1_HeavyChain_CH2_constant_domain 7606 15248,22890, 30532, 38174, 45816, 53458, 61100IgG1_HeavyChain_CH2_constant_domain 7607 15249, 22891, 30533, 38175,45817, 53459, 61101 IgG1_HeavyChain_CH2_constant_domain 7608 15250,22892, 30534, 38176, 45818, 53460, 61102IgG1_HeavyChain_CH2_constant_domain 7609 15251, 22893, 30535, 38177,45819, 53461, 61103 IgG1_HeavyChain_CH2_constant_domain 7610 15252,22894, 30536, 38178, 45820, 53462, 61104IgG1_HeavyChain_CH2_constant_domain 7611 15253, 22895, 30537, 38179,45821, 53463, 61105 IgG1_HeavyChain_CH2_constant_domain 7612 15254,22896, 30538, 38180, 45822, 53464, 61106IgG1_HeavyChain_CH2_constant_domain 7613 15255, 22897, 30539, 38181,45823, 53465, 61107 IgG1_HeavyChain_CH2_constant_domain 7614 15256,22898, 30540, 38182, 45824, 53466, 61108IgG1_HeavyChain_CH2_constant_domain 7615 15257, 22899, 30541, 38183,45825, 53467, 61109 IgG1_HeavyChain_CH2_constant_domain 7616 15258,22900, 30542, 38184, 45826, 53468, 61110IgG1_HeavyChain_CH2_constant_domain 7617 15259, 22901, 30543, 38185,45827, 53469, 61111 IgG1_HeavyChain_CH2_constant_domain 7618 15260,22902, 30544, 38186, 45828, 53470, 61112IgG1_HeavyChain_CH2_constant_domain 7619 15261, 22903, 30545, 38187,45829, 53471, 61113 IgG1_HeavyChain_CH2_constant_domain 7620 15262,22904, 30546, 38188, 45830, 53472, 61114IgG1_HeavyChain_CH2_constant_domain 7621 15263, 22905, 30547, 38189,45831, 53473, 61115 IgG1_HeavyChain_CH2_constant_domain 7622 15264,22909, 30548, 38190, 45832, 53474, 61116IgG1_HeavyChain_CH2_constant_domain 7623 15265, 22907, 30549, 38191,45833, 53475, 61117 IgG1_HeavyChain_CH2_constant_domain 7624 15266,22908, 30550, 38192, 45834, 53476, 61118IgG1_HeavyChain_CH3_constant_domain 7625 15267, 22909, 30551, 38193,45835, 53477, 61119 IgG1_HeavyChain_CH3_constant_domain 7626 15268,22910, 30552, 38194, 45836, 53478, 61120IgG1_HeavyChain_CH3_constant_domain 7627 15269, 22911, 30553, 38195,45837, 53479, 61121 IgG1_HeavyChain_CH3_constant_domain 7628 15270,22912, 30554, 38196, 45838, 53480, 61122IgG2_HeavyChain_CH1_constant_domain 7629 15271, 22913, 30555, 38197,45839, 53481, 61123 IgG2_HeavyChain_CH1_constant_domain 7630 15272,22914, 30556, 38198, 45840, 53482, 61124IgG2_HeavyChain_CH2_constant_domain 7631 15273, 22915, 30557, 38199,45841, 53483, 61125 IgG2_HeavyChain_CH2_constant_domain 7632 15274,22916, 30558, 38200, 45842, 53484, 61126IgG2_HeavyChain_CH2_constant_domain 7633 15275, 22917, 30559, 38201,45843, 53485, 61127 IgG2_HeavyChain_CH2_constant_domain 7634 15276,22918, 30560, 38202, 45844, 53486, 61128IgG2_HeavyChain_CH2_constant_domain 7635 15277, 22919, 30561, 38203,45845, 53487, 61129 IgG2_HeavyChain_CH2_constant_domain 7636 15278,22920, 30562, 38204, 45846, 53488, 61130IgG2_HeavyChain_CH2_constant_domain 7637 15279, 22921, 30563, 38205,45847, 53489, 61131 IgG2_HeavyChain_CH2_constant_domain 7638 15280,22922, 30564, 38206, 45848, 53490, 61132IgG2_HeavyChain_CH3_constant_domain 7639 15281, 22923, 30565, 38207,45849, 53491, 61133 IgG4_HeavyChain_CH1_constant_domain 7640 15282,22924, 30565, 38208, 45850, 53492, 61134IgG4_HeavyChain_CH2_constant_domain 7641 15283, 22925, 30567, 38209,45851, 53493, 61135 IgG4_HeavyChain_CH3_constant_domain 7642 15284,22926, 30568, 38210, 45852, 53494, 61136

Accordingly, it is preferred that the constant region or the fragment orvariant thereof encoded by the at least one coding sequence comprises orconsists of an amino acid sequence as set forth in any of SEQ ID NOs:7571-7642. It is also preferred that the at least one coding sequencecomprises or consists of a nucleic acid sequence as set forth in any ofSEQ ID NOs: 15213-15284, 22855-22926, 30497-30568, 38139-38210,45781-45852, 53423-53494, and 61065-61136.

Preferably, the RNA according to the present invention comprises (i) acoding sequence encoding a heavy chain variable region, or a fragment orvariant thereof, and a heavy chain constant region, or a fragment orvariant thereof; and/or (ii) a coding sequence encoding a light chainvariable region, or a fragment or variant thereof, and a light chainconstant region, or a fragment or variant thereof.

Preferably, the antibody or the fragment thereof, which is encoded bythe RNA according to the present invention, is chosen from monoclonaland polyclonal antibodies or fragments thereof, chimeric antibodies orfragments thereof, human antibodies or fragments thereof, humanizedantibodies or fragments thereof, and intrabodies or fragments thereof.

It is also preferred that the antibody or the fragment thereof, which isencoded by the RNA according to the present invention, is a monospecificor a multispecific antibody or antibody fragment. Preferably, theantibody or the fragment thereof, which is encoded by the RNA accordingto the present invention, is a bispecific or a trispecific antibody orantibody fragment.

As used herein, the term “multispecific” refers to the ability to bindto at least two different epitopes, e.g. on different antigens, whereasa monospecific antibody can only bind to one type of antigens (amonospecific antibody comprising one or more binding site for one andthe same epitope). Thus, terms like “monospecific”, “bispecific”,trispecific”, “tetraspecific” etc. refer to the number of differentepitopes to which the antibody can bind to. For example, conventionalmonospecific IgG-type antibodies have two identical epitope bindingsites (paratopes) and can, thus, only bind to identical epitopes (butnot to different epitopes). A multispecific antibody, in contrast, hasat least two different types of paratopes and can, thus, bind to atleast two different epitopes. Moreover, a single “specificity” may referto one, two, three or more identical paratopes in a single antibody (theactual number of paratopes in one single antibody molecule is referredto as “valency”). For example, a single native IgG antibody ismonospecific and bivalent, since it has two identical paratopes.Accordingly, a multispecific antibody comprises at least two (different)paratopes. Thus, the term “multispecific antibodies” refers toantibodies having more than one paratope and the ability to bind to twoor more different epitopes. The term “multispecific antibodies”comprises in particular bispecific antibodies, but typically alsoantibodies, which bind in particular to three or more differentepitopes, i.e. antibodies with three or more paratopes.

Accordingly, the present invention does not only provide RNA moleculesencoding monospecific antibodies or fragments or variants thereof, butRNA molecules which code for multispecific, such as bispecific ortrispecific, antibodies or fragments or variants thereof can also beprovided in the context of the present invention. Bispecific antibodiesin the context of the present invention are preferably antibodies whichcan act as adaptors between an effector and a corresponding target, e.g.for recruiting effector molecules (e.g. toxins, active compounds(drugs), cytokines etc.), targeting of effector cells (e.g. CTL, NKcells, macrophages, granulocytes etc. (see, for example, review byKontermann R. E., Acta Pharmacol. Sin, 2005, 26(1): 1-9). In thiscontext, bispecific antibodies are in principle built up such as isdescribed here in general for antibodies, these bispecific antibodiese.g. recognizing two different antigens, immunogens or epitopes, oractive compounds, cells, or other molecules (or structures) as mentionedabove, i.e. the antigen-binding regions of the antibody are specific fortwo different molecules (or structures). The various antigens,immunogens or epitopes etc., for example, can thus be brought spatiallyclose. Furthermore, by the binding e.g. of a binding domain or otherspecificities, the function of the antibody can be extendedspecifically, e.g. of a binding protein, an immunotoxin etc. Suchbispecific antibodies can also be single-chain antibodies (e.g. scFvfragments etc.). Bispecific antibodies can be used, for example, tobring two reaction partners, e.g. two cells, two proteins, a protein andthe substrate thereof etc., spatially close in order to promote aninteraction between these (e.g. protein-protein interactions, substrateconversions, modifications etc.). Bispecific antibodies are preferablyused above all to bring effector cells (such as, for example, T cells,NK cells, macrophages etc.) and target cells (e.g. tumour cells,infected cells etc.) spatially close. Examples of bispecific antibodiescan include, without being limited thereto, e.g. those antibodies orantibody fragments which bind on the one hand a surface factor asdescribed here, and on the other hand an antigen as described here,preferably a tumour antigen as described here. This includes e.g. CD28and a tumour antigen (Grosse-Hovest L. et al., 2003, Eur. Immunol.33(5); 1334-40, (A recombinant bispecific single-chain antibody inducestargeted, supra-agonistic CD28-stimulation and tumor cell killing)),CD19 and CD3 (CD19 tumour antigen of B cell lymphoma) etc.

Preferably, the antibody fragment encoded by the RNA according to thepresent invention is selected from the group consisting of Nanobody;Nanobody-HAS; BiTE; Diabody; DART; TandAb; scDiabody; sc-Diabody-CH3;Diabody-CH3; Triple Body; Miniantibody; Minibody; TriBi minibody;scFv-CH3 KIH; Fab-scFv; scFv-CH-CL-scFv; F(ab′)2; F(ab′)2-scFv2;scFv-KIH; Fab-scFv-Fc; Tetravalent HCAb; scDiabody-Fc; Diabody-Fc;Tandem scFv-Fc; Fab; Fab′; Fc; Facb; pFc′; Fd; Fv or scFv antibodyfragment. These bispecific antibody formats are shown and described forexample in Spiess C., Zhai Q. and Carter P. J. (2015) MolecularImmunology 67: 95-106, in particular FIG. 1 and correspondingdescription, e.g. p. 95-101.

Preferably, the antibody or the fragment thereof, which is encoded bythe RNA according to the present invention, comprises a binding site foran Fc receptor, in particular an Fc moiety. As used herein, the term “Fcmoiety” refers to a sequence derived from the portion of animmunoglobulin heavy chain beginning in the hinge region just upstreamof the papain cleavage site and ending at the C-terminus of theimmunoglobulin heavy chain. Preferably, the “Fc moiety” comprises abinding site for an Fc receptor. However, it is also preferred that anFc moiety may mediate a functionality different from binding to an Fcreceptor, for example binding to a protein of the complement system.Accordingly, an “Fc moiety” may be a complete Fc region or a part (e.g.,a domain) thereof. Preferably, the “Fc moiety” mediates the fullfunctionality of a complete Fc region, e.g. including Fc receptorbinding and, optionally, binding to a protein from the complementsystem. Thus, the antibody as used according to the present inventionpreferably comprises a complete Fc region, whereby a complete Fc regioncomprises at least a hinge domain, a CH2 domain, and a CH3 domain. TheFc moiety may also comprise one or more amino acid insertions,deletions, or substitutions relative to a naturally-occurring Fc region.For example, at least one of a hinge domain, CH2 domain or CH3 domain(or portion thereof) may be deleted. For example, an Fc moiety maycomprise or consist of: (i) hinge domain (or portion thereof) fused to aCH2 domain (or portion thereof), (ii) a hinge domain (or portionthereof) fused to a CH3 domain (or portion thereof), (iii) a CH2 domain(or portion thereof) fused to a CH3 domain (or portion thereof), (iv) ahinge domain (or portion thereof), (v) a CH2 domain (or portionthereof), or (vi) a CH3 domain or portion thereof.

The antibody, or the antigen binding fragment thereof, which is encodedby the RNA according to the present invention, may be of any antibodyformat. In particular, antibodies preferably encompass “whole”antibodies, such as whole IgG- or IgG-like molecules, while antigenbinding fragments in the context of the present invention preferablyrefer to small recombinant formats, such as bispecific T-cell engagers(BiTes), tandem single chain variable fragment molecules (taFvs),diabodies (Dbs), single chain diabodies (scDbs) and various otherderivatives of these (cf. bispecific antibody formats as described byByrne H. et al. (2013) Trends Biotech, 31 (11): 621-632 with FIG. 2showing various bispecific antibody formats; Weidle U. H. et al. (2013)Cancer Genomics and Proteomics 10: 1-18, in particular FIG. 1 showingvarious bispecific antibody formats; and Chan, A. C. and Carter, P. J.(2010) Nat Rev Immu 10: 301-316 with FIG. 3 showing various bispecificantibody formats). Examples of bispecific antibody formats include, butare not limited to, quadroma, chemically coupled Fab (fragment antigenbinding), and BiTE® (bispecific T cell engager). In one embodiment ofthe present invention the antibody used is preferably a BiTE®(bispecific T cell engager).

Thus, the antibody, or the antigen binding fragment thereof, which isencoded by the RNA according to the present invention, may be selectedfrom the group comprising hybrid hybridoma (quadroma); Multispecificanticalin platform (Pieris); Diabodies; Single chain diabodies; Tandemsingle chain Fv fragments; TandAbs, Trispecific Abs (Affimed) (105-110kDa); Darts (dual affinity retargeting; Macrogenics); Bispecific Xmabs(Xencor); Bispecific T cell engagers (Bites; Amgen; 55kDa);Triplebodies; Tribody=Fab-scFv Fusion Protein (CreativeBiolabs)multifunctional recombinant antibody derivates (110 kDa); Duobodyplatform (Genmab); Dock and lock platform; Knob into hole (KIH)platform; Humanized bispecific IgG antibody (REGN1979) (Regeneron); Mabebispecific antibodies (F-Star); DVD-Ig=dual variable domainimmunoglobulin (Abbvie); kappa-lambda bodies; TBTI=tetravalentbispecific tandem Ig; and CrossMab.

The antibody, or the antigen binding fragment thereof, which is encodedby the RNA according to the present invention, may be selected frombispecific IgG-like antibodies (BsIgG) comprising CrossMab; DAF(two-in-one); DAF (four-in-one); DutaMab; DT-IgG; Knobs-in-holes commonLC; Knobs-in-holes assembly; Charge pair; Fab-arm exchange; SEEDbody;Triomab; LUZ-Y; Fcab; κλ-body; and Orthogonal Fab. These bispecificantibody formats are shown and described for example in Spiess C., ZhaiQ. and Carter P. J. (2015) Molecular Immunology 67: 95-106, inparticular FIG. 1 and corresponding description, e.g. p. 95-101.

Preferably, the antibody, or the antigen binding fragment thereof, whichis encoded by the RNA according to the present invention, may beselected from IgG-appended antibodies with an additional antigen-bindingmoiety comprising DVD-IgG; IgG(H)-scFv; scFv-(H)IgG; IgG(L)-scFv;scFV-(L)IgG; IgG(L,H)-Fv; IgG(H)-V; V(H)-IgG; IgG(L)-V; V(L)-IgG; KIHIgG-scFab; 2scFv-IgG; IgG-2scFv; scFv4-Ig; scFv4-Ig; Zybody; and DVI-IgG(four-in-one). These bispecific antibody formats are shown and describedfor example in Spiess C., Zhai Q. and Carter P. J. (2015) MolecularImmunology 67: 95-106, in particular FIG. 1 and correspondingdescription, e.g. p. 95-101.

Preferably, the antibody, or the antigen binding fragment thereof, whichis encoded by the RNA according to the present invention, may beselected from bispecific antibody fragments comprising Nanobody;Nanobody-HAS; BiTE; Diabody; DART; TandAb; scDiabody; sc-Diabody-CH3;Diabody-CH3; Triple Body; Miniantibody; Minibody; TriBi minibody;scFv-CH3 KIH; Fab-scFv; scFv-CH-CL-scFv; F(ab′)2; F(ab′)2-scFv2;scFv-KIH; Fab-scFv-Fc; Tetravalent HCAb; scDiabody-Fc; Diabody-Fc;Tandem scFv-Fc; and Intrabody. These bispecific antibody formats areshown and described for example in Spiess C., Zhai Q. and Carter P. J.(2015) Molecular Immunology 67: 95-106, in particular FIG. 1 andcorresponding description, e.g. p. 95-101.

Preferably, the antibody, or the antigen binding fragment thereof, whichis encoded by the RNA according to the present invention, may beselected from bispecific fusion proteins comprising Dock and Lock;ImmTAC; HSAbody; scDiabody-HAS; and Tandem scFv-Toxin. These bispecificantibody formats are shown and described for example in Spiess C., ZhaiQ. and Carter P. J. (2015) Molecular Immunology 67: 95-106, inparticular FIG. 1 and corresponding description, e.g. p. 95-101.

In particular, the antibody, or the antigen binding fragment thereof,which is encoded by the RNA according to the present invention, may beselected from bispecific antibody conjugates comprising IgG-IgG;Cov-X-Body; and scFv1-PEG-scFv2. These bispecific antibody formats areshown and described for example in Spiess C., Zhai Q. and Carter P. J.(2015) Molecular Immunology 67: 95-106, in particular FIG. 1 andcorresponding description, e.g. p. 95-101.

Depending on the amino acid sequence of the constant region of theirheavy chains, antibodies or immunoglobulins are divided in the classes:IgA, IgD, IgE, IgG and IgM, and several of these may be further dividedinto subclasses, e.g. IgG1, IgG2, IgG3, and IgG4, IgA1 and IgA2. Theheavy chain constant regions that correspond to the different classes ofimmunoglobulins are called α, ε, γ, and μ, respectively. The antibodiesaccording to the invention are preferably of IgG type. It is alsopreferred that the antibody, which is encoded by the RNA according tothe present invention, has an IgG-like format, which includes, inaddition to IgG type antibodies, recombinant antibodies based on IgG,such as the IgG-appended antibodies and the bispecific IgG-likeantibodies described above.

Preferably, the antibody, or the antigen binding fragment thereof, whichis encoded by the RNA according to the present invention, is asingle-chain antibody or a single-chain antibody fragment. It is alsopreferred that the antibody, or the antigen binding fragment thereof,which is encoded by the RNA according to the present invention, is amultiple-chain antibody or a multiple-chain antibody fragment. The term“chain”, as used herein, in particular in the context of a single-chainand a multiple-chain antibody, typically refers to a chain of aminoacids connected by a peptide bond, such that a “chain” typically refersto a single peptide or protein. Accordingly, in particular twopeptides/proteins connected via disulfide bridges (also referred to as“SS-bonds”) do not form a single chain. For example, an sc-Fv antibody,wherein the variable regions are connected via a peptide linker isreferred to—in the context of the present invention—as a single-chainantibody, whereas it were referred to as a multiple-chain antibody, ifthe variable regions are connected via a disulfide bridge.

It is also preferred that the antibody, or the antigen binding fragmentthereof, which is encoded by the RNA according to the present invention,specifically recognizes and binds to tumour-specific surface antigenschosen from (TSSA), 5T4, α5β1-integrin, 707-AP, AFP, ART-4, B7H4, BAGE,β-catenin/m, Bcr-abl, MN/C IX-antigen, CA125, CAMEL, CAP-1, CASP-8,β-catenin/m, CD4, CD19, CD20, CD22, CD25, CDC27/m, CD 30, CD33, CD52,CD56, CD80, CDK4/m, CEA, CT, Cyp-B, DAM, EGFR, ErbB3, ELF2M, EMMPRIN,EpCam, ETV6-AML1, G250, GAGE, GnT-V, Gp100, HAGE, HER-2/neu,HLA-A*0201-R170I, HPV-E7, HSP70-2M, HAST-2, hTERT (or hTRT), iCE,IGF-1R, IL-2R, IL-5, KIAA0205, LAGE, LDLR/FUT, MAGE, MART-1/Melan-A,MART-2/Ski, MC1R, myosin/m, MUC1, MUM-1, -2, -3, NA88-A, PAP,proteinase-3, p190 minor bcr-abl, Pml/RARα, PRAME, PSA, PSM, PSMA, RAGE,RU1 or RU2, SAGE, SART-1 or SART-3, survivin, TEL/AML1, TGFβ, TPI/m,TRP-1, TRP-2, TRP-2/INT2, VEGF and WT1, NY-Eso-1 and NY-Eso-B, asdescribed above.

Preferably, the at least one coding sequence of the RNA according to thepresent invention encodes an antibody selected from the group consistingof AAB-003; Abagovomab; Abciximab; Abituzumab; Abrilumab; Actoxumab;Adalimumab; Aducanumab; Afasevikumab; Aflibercept; Afutuzuab;Afutuzumab; Alacizumab_pegol; Alemtuzumab; Alirocumab; ALX-0061;Amatuximab; Anetumab_ravtansine; Anifrolumab; Anrukinzumab; Apolizumab;Apomab; Aquaporumab; Arcitumomab_99tc; Ascrinvacumab; Aselizuab;Atezolizumab; Atinumab; Atlizuab; Aurograb; Avelumab; Bapineuzumab;Basiliximab; Bavituximab; Begelomab; Benralizumab; Betalutin;Bevacituzuab; Bevacizumab_154-aspartic_acid;Bevacizumab_154-substitution; Bevacizumab_180-serine;Bevacizumab_180-substitution; Bevacizumab_beta; Bevacizumab;Bevacizumab-rhuMAb-VEGF; Bezlotoxumab; Bimagrumab; Bimekizumab;Bleselumab; Blinatumomab; Blinatumumab; Blontuvetmab; Blosozumab;Bococizumab; Brentuximab_vedotin; Briakinumab; Brodalumab; Brolucizumab;Brontictuzumab; BTT-1023; Burosumab; Canakinumab; Cantuzumab;Cantuzumab_mertansine; Cantuzumab_ravtansine; Caplacizumab; Carlumab;Cergutuzumab_amunaleukin; Certolizumab_pegol; Cetuximab;Citatuzumab_bogatox; Cixutumumab; Clazakizumab; Clivatuzumab_tetraxetan;Codrituzumab; Coltuximab_ravtansine; Conatumumab_CV; Conatumumab;Concizumab; Crenezumab; Crotedumab; Dacetuzumab; Dacliximab; Daclizumab;Dalotuzumab; Dapirolizumab_pegol; Daratumumab; Dectrekumab; Demcizumab;Denintuzumab_mafodotin; Denosumab; Depatuxizumab;Depatuxizumab_mafodotin; Dinutuximab_beta; Dinutuximab; Diridavumab;Domagrozumab; Drozituab; Drozitumab; Duligotumab; Duligotuzumab;Dupilumab; Durvalumab; Dusigitumab; Ecromeximab; Eculizumab; Efalizumab;Efungumab; Eldelumab; Elgemtumab; Elotuzumab; Emactuzumab; Emibetuzumab;Emicizumab; Enavatuzumab; Enfortumab; Enfortumab_vedotin; Enoblituzumab;Enokizumab; Enoticumab; Ensituximab; Entolimod; Epratuzumab;Eptacog_beta; Erlizuab; Etaracizumab; Etrolizuab; Etrolizumab;Evinacumab; Evolocumab; Exbivirumab; Farletuzumab; Fasinumab;Fezakinumab; FG-3019; Fibatuzumab; Ficlatuzumab; Figitumumab; Firivumab;Flanvotumab; Fletikumab; Fontolizumab; Foralumab; Foravirumab;Fresolimumab; Fulranumab; Futuximab; Galcanezumab; Galiximab; Ganitumab;Gantenerumab; Gemtuzumab; Gemtuzumab_ozogamicin; Gevokizumab;Girentuximab; Glembatumumab; Goilixiab; Guselkumab; HuMab-001;HuMab-005; HuMab-006; HuMab-019; HuMab-021; HuMab-025; HuMab-027;HuMab-032; HuMab-033; HuMab-035; HuMab-036; HuMab-041; HuMab-044;HuMab-049; HuMab-050; HuMab-054; HuMab-055; HuMab-059; HuMab-060;HuMab-067; HuMab-072; HuMab-084; HuMab-091; HuMab-093; HuMab-098;HuMab-100; HuMab-106; HuMab_10F8; HuMab-111; HuMab-123; HuMab-124;HuMab-125; HuMab-127; HuMab-129; HuMab-132; HuMab-143; HuMab-150;HuMab-152; HuMab-153; HuMab-159; HuMab-160; HuMab-162; HuMab-163;HuMab-166; HuMab-167; HuMab-169; HuMab-7D8; huMAb-anti-MSP10.1;huMAb-anti-MSP10.2; HUMAB-Clone_18; HUMAB-Clone_22; HuMab-L612;HuMab_LC5002-002; HuMab_LC5002-003; HuMab_LC5002-005; HuMab_LC5002-007;HuMab_LC5002-018; Ibalizumab; Ibritumomab_tiuxetan; Icrucumab;Idarucizumab; Igatuzuab; IGF-IR_HUMAB-1A; IGF-IR_HUMAB-23;IGF-IR_HUMAB-8; ImAb1; Imalumab; Imgatuzumab; Inclacumab;Indatuximab_ravtansine; Indusatumab_vedotin; Inebilizumab;Insulin_peglispro; Interferon_beta-1b; Intetumumab;Iodine_(124I)_Girentuximab; Iodine_(131I)_Derlotuxiab_biotin;lodine_(131I)_Derlotuximab_biotin; Ipilimumab; Iratumumab; Isatuximab;Itolizumab; Ixekizumab; Labetuzumab_govitecan; Lambrolizumab;Lampalizumab; Lanadelumab; Landogrozumab; Laprituximab_emtansine;Lealesoab; Lebrikizumab; Lenercept_chain1; Lenzilumab; Lerdelimumab;Lexatumumab; Libivirumab; Lifastuzumab; Lifastuzumab_vedotin;Ligelizumab; Lilotomab; Lintuzumab; Lirilumab; Lodelcizumab; Lokivetmab;Lorvotuzumab_mertansine; Lpathomab; Lucatumumab; Lulizumab_pegol;Lumiliximab; Lumretuzumab; Lutetium_(177Lu)_lilotomab_satetraxetan;Margetuximab; Marzeptacog_alfa; Matuzumab; Mavrilimumab; MDX-1303;Mepolizumab; Metelimumab; Milatuzumab; Mirvetuximab; Modotuximab;Mogamulizumab; Monalizumab; Motavizumab; Moxetumomab_pasudotox;Muromonab-CD3; Namilumab; Naptumomab_estafenatox; Narnatumab;Natalizumab; Navicixizumab; Navivumab; Ndimab-varB; Necitumumab;Neliximab; Nemolizumab; Nesvacumab; Neuradiab; Nimotuzumab; Nivolumab;Obiltoxaximab; Obinutuzumab; Ocaratuzumab; Ocrelizumab; Ofatumumab;Olaratumab; Olizuab; Olokizumab; Omalizumab; Onartuzumab; Ontuxizumab;Opicinumab; Oportuzumab_monatox; Oreptacog_alfa; Orticumab;Otelixizumab; Otlertuzumab; Oxelumab; Ozanezumab; Ozoralizumab;Palivizumab; Pamrevlumab; Panitumumab; Pankoab; PankoMab; Panobacumab;Parsatuzumab; Pascolizumab; Pasotuxizumab; Pateclizumab; Patritumab;Pembrolizumab; Perakizumab; Pertuzuab; Pertuzumab;Pexelizumab_h5g1.1-scFv; Pexelizumab; PF-05082566; PF-05082568;Pidilizumab; Pinatuzumab_vedotin; Placulumab; Plozalizumab; Pogalizumab;Polatuzumab_vedotin; Ponezumab; Pritoxaximab; Pritumumab; Quilizumab;Racotumomab; Radretumab; Rafivirumab; Ralpancizumab; Ramucirumab;Ranibizivab; Ranibizumab; Refanezumab; REGN2810; rhuMab_HER2(9CI);rhuMab_HER2; rhuMAb-VEGF; Rilotumumab; Rinucumab; Risankizumab;Rituximab; Rivabazumab_pegol; Robatumumab; Roledumab; Romosozumab;Rontalizuab; Rontalizumab; Rovalpituzumab_tesirine; Rovelizumab;Ruplizumab; Sacituzumab_govitecan; Samalizumab; Sarilumab;Satumomab_pendetide; Secukinumab; Seribantumab; Setoxaximab;Sifalimumab; Siltuximab; Simtuzumab; Sirukumab; Sofituzumab_vedotin;Solanezumab; Solitomab; Sonepcizumab; Stamulumab; Suptavumab; Suvizumab;Tabalumab; Tacatuzuab; Tadocizumab; Talizumab; Tamtuvetmab; Tanezumab;Tarextumab; Tefibazumab; Tenatumomab; Teneliximab; Teplizumab;Teprotumumab; Tesidolumab; Tezepelumab; ThioMAb-chMA79b-HC(A118C);ThioMab-hu10A8.v1-HC(A118C); ThioMab-hu10A8.v1-HC(V205C);ThioMab-hu10A8.v1-LC(A118C); ThioMab-hu10A8.v1-LC(V205C);ThioMAb-huMA79b.v17-HC(A118C); ThioMAb-huMA79b.v18-HC(A118C);ThioMAb-huMA79b.v28-HC(A118C); ThioMAb-huMA79b.v28-LC(V205C); Ticilivab;Tigatuzumab; Tildrakizumab; Tisotumab_vedotin; Tocilizumab; Tosatoxumab;Tositumomab; Tovetumab; Tralokinumab; Trastuzuab; Trastuzumab_emtansine;Trastuzumab; TRC-105; Tregalizumab; Tremelimumab; Trevogrumab;Tucotuzumab_celmoleukin; Ublituximab; Ulocuplumab; Urelumab;Urtoxazumab; Ustekinumab; Vadastuximab_talirine; Vandortuzumab_vedotin;Vantictumab; Vanucizumab; Varlilumab; Vatelizumab; Vedolizumab;Veltuzumab; Vesencumab; Visilizumab; Volociximab; Vorsetuzumab;Vorsetuzumab_mafodotin; Yttrium_(90Y)_clivatuzumab_tetraxetan;Yttrium_Y_90_epratuzumab_tetraxetan; Yttrium_Y_90_epratuzumab;Zalutumumab; Zanolimumab; Zatuximab; Andecaliximab; Aprutumab;Azintuxizumab; Brazikumab; Cabiralizumab; Camrelizumab; Cosfroviximab;Crizanlizumab; Dezamizumab; Duvortuxizumab; Elezanumab; Emapalumab;Eptinezumab; Erenumab; Fremanezumab; Frunevetmab; Gatipotuzumab;Gedivumab; Gemetuzumab; Gilvetmab; Ifabotuzumab; Lacnotuzumab;Larcaviximab; Lendalizumab; Lesofavumab; Letolizumab; Losatuxizumab;Lupartumab; Lutikizumab; Oleclumab; Porgaviximab; Prezalumab;Ranevetmab; Remtolumab; Rosmantuzumab; Rozanolixizumab; Sapelizumab;Selicrelumab; Suvratoxumab; Tavolixizumab; Telisotuzumab;Telisotuzumab_vedotin; Timigutuzumab; Timolumab; Tomuzotuximab;Trastuzumab_duocarmazine; Varisacumab; Vunakizumab; Xentuzumab;anti-rabies_SO57; anti-rabies_SOJB; anti-rabies_SOJA; anti-rabies;anti-RSV_SITB; anti-alpha-toxin_4U6V; anti-IsdB_5D1Q; anti-IsdB_5D1X;anti-IsdB_5D1Z; anti-HIV b12; anti-HIV_2G12; anti-HIV_4E10;anti-HIV_VRC01; anti-HIV_PG9; anti-HIV_VRC07; anti-HIV_3BNC117;anti-HIV_10-1074; anti-HIV_PGT121; anti-HIV_PGDM1400; anti-HIV_N6;anti-HIV_10E8; anti-HIV_12A12; anti-HIV_12A21; anti-HIV_35022;anti-HIV_3BC176; anti-HIV_3BNC55; anti-HIV_3BNC60; anti-HIV_447-52D;anti-HIV_5H/I1-BMV-D5; anti-HIV_8ANC195; anti-HIV_CAP256-VRC26.01;anti-HIV_CAP256-VRC26.02; anti-HIV_CAP256-VRC26.03;anti-HIV_CAP256-VRC26.04; anti-HIV_CAP256-VRC26.05;anti-HIV_CAP256-VRC26.06; anti-HIV_CAP256-VRC26.07;anti-HIV_CAP256-VRC26.08; anti-HIV_CAP256-VRC26.09;anti-HIV_CAP256-VRC26.10; anti-HIV_CAP256-VRC26.11;anti-HIV_CAP256-VRC26.12; anti-HIV_CAP256-VRC26.I1;anti-HIV_CAP256-VRC26.I2; anti-HIV_CAP256-VRC26.UCA; anti-HIV_CH01;anti-HIV_CH02; anti-HIV_CH03; anti-HIV_CH04; anti-HIV_CH103;anti-HIV_M66.6; anti-HIV_NIH45-46; anti-HIV_PG16; anti-HIV_PGT122;anti-HIV_PGT123; anti-HIV_PGT125; anti-HIV_PGT126; anti-HIV_PGT127;anti-HIV_PGT128; anti-HIV_PGT130; anti-HIV_PGT131; anti-HIV_PGT135;anti-HIV_PGT136; anti-HIV_PGT137; anti-HIV_PGT141; anti-HIV_PGT142;anti-HIV_PGT143; anti-HIV_PGT144; anti-HIV_PGT145; anti-HIV_PGT151;anti-HIV_PGT152; anti-HIV_VRC-CH30; anti-HIV_VRC-CH31;anti-HIV_VRC-CH32; anti-HIV_VRC-CH33; anti-HIV_VRC-CH34;anti-HIV_VRC-PG04; anti-HIV_VRC-PG04b; anti-HIV_VRC-PG20;anti-HIV_VRC02; anti-HIV_VRC03; anti-HIV_VRC23; anti-HIV_5CCK;anti-HIV_5AWN; anti-HIV_3QEG; anti-HIV_1N0X; anti-HIV_3QEH;anti-HIV_2B1H; anti-HIV_3TNM; anti-HIV_3UJJ; anti-HIV_3UJI;anti-HIV_2QSC; anti-HIV_3MLZ; anti-HIV_3MLX; anti-HIV_3MLW;anti-HIV_3MLV; anti-HIV_3MLU; anti-HIV_3MLT; anti-HIV_3GO1;anti-HIV_4XCY; anti-HIV_4YBL; anti-HIV_4R4N; anti-HIV_4R4B;anti-HIV_3JUY; anti-HIV_4KG5; anti-HIV-1; anti-HIV_V3; anti-HIV_CD4bs;anti-HIV_V2; anti-HIV_C38-VRC18.02; anti-HIV_44-VRC13.02; anti-HIV_45;anti-HIV_cap256-206-252885; anti-HIV_cap256-206-249183;anti-HIV_cap256-206-220956; anti-HIV_cap256-206-220629;anti-HIV_cap256-206-200599; anti-HIV_cap256-206-186347;anti-HIV_cap256-206-186226; anti-HIV_cap256-206-179686;anti-HIV_cap256-206-173707; anti-HIV_cap256-206-173339;anti-HIV_cap256-206-172689; anti-HIV_cap256-206-162744;anti-HIV_cap256-206-146057; anti-HIV_cap256-206-139519;anti-HIV_cap256-206-136316; anti-HIV_cap256-206-116098;anti-HIV_cap256-206-115862; anti-HIV_cap256-206-107018;anti-HIV_cap256-206-098644; anti-HIV_cap256-206-098135;anti-HIV_cap256-206-096276; anti-HIV_cap256-206-092794;anti-HIV_cap256-206-086817; anti-HIV_cap256-206-086446;anti-HIV_cap256-206-086180; anti-HIV_cap256-206-083708;anti-HIV_cap256-206-079556; anti-HIV_cap256-206-078657;anti-HIV_cap256-206-075802; anti-HIV_cap256-206-069097;anti-HIV_cap256-206-067758; anti-HIV_cap256-206-057019;anti-HIV_cap256-206-055385; anti-HIV_cap256-206-053187;anti-HIV_cap256-206-053139; anti-HIV_cap256-206-050350;anti-HIV_cap256-206-046207; anti-HIV_cap256-206-043389;anti-HIV_cap256-206-042555; anti-HIV_cap256-206-029720;anti-HIV_cap256-206-028848; anti-HIV_cap256-206-027652;anti-HIV_cap256-206-024075; anti-HIV_cap256-206-008748;anti-HIV_cap256-206-008530; anti-HIV_cap256-176-723043;anti-HIV_cap256-176-600049; anti-HIV_cap256-176-531926;anti-HIV_cap256-176-504134; anti-HIV_cap256-119-186229;anti-HIV_cap256-119-183891; anti-HIV_cap256-119-183631;anti-HIV_cap256-119-182676; anti-HIV_cap256-119-180772;anti-HIV_cap256-119-180508; anti-HIV_cap256-119-180260;anti-HIV_cap256-119-180173; anti-HIV_cap256-119-179839;anti-HIV_cap256-119-179262; anti-HIV_cap256-119-178995;anti-HIV_cap256-119-178455; anti-HIV_cap256-119-177993;anti-HIV_cap256-119-177727; anti-HIV_cap256-119-176746;anti-HIV_cap256-119-176241; anti-HIV_cap256-119-175215;anti-HIV_cap256-119-173928; anti-HIV_cap256-119-173495;anti-HIV_cap256-119-172882; anti-HIV_cap256-119-172429;anti-HIV_cap256-119-172223; anti-HIV_cap256-119-171838;anti-HIV_cap256-119-171587; anti-HIV_cap256-119-169596;anti-HIV_cap256-119-169523; anti-HIV_cap256-119-169462;anti-HIV_cap256-119-169092; anti-HIV_cap256-119-168680;anti-HIV_cap256-119-166385; anti-HIV_cap256-119-165943;anti-HIV_cap256-119-165738; anti-HIV_cap256-119-164913;anti-HIV_cap256-119-164167; anti-HIV_cap256-119-163558;anti-HIV_cap256-119-162043; anti-HIV_cap256-119-161718;anti-HIV_cap256-119-161675; anti-HIV_cap256-119-161053;anti-HIV_cap256-119-159499; anti-HIV_cap256-119-159114;anti-HIV_cap256-119-156751; anti-HIV_cap256-119-155656;anti-HIV_cap256-119-154420; anti-HIV_cap256-119-153954;anti-HIV_cap256-119-153864; anti-HIV_cap256-119-153793;anti-HIV_cap256-119-153462; anti-HIV_cap256-119-153124;anti-HIV_cap256-119-153025; anti-HIV_cap256-119-152713;anti-HIV_cap256-119-151794; anti-HIV_cap256-119-150980;anti-HIV_cap256-119-148895; anti-HIV_cap256-119-148848;anti-HIV_cap256-119-148743; anti-HIV_cap256-119-148595;anti-HIV_cap256-119-148490; anti-HIV_cap256-119-148470;anti-HIV_cap256-119-148107; anti-HIV_cap256-119-147933;anti-HIV_cap256-119-147434; anti-HIV-cap256-119-146106;anti-HIV_cap256-119-145604; anti-HIV_cap256-119-143998;anti-HIV_cap256-119-143441; anti-HIV_cap256-119-141307;anti-HIV_cap256-119-140896; anti-HIV_cap256-119-140090;anti-HIV_cap256-119-140037; anti-HIV_cap256-119-139135;anti-HIV_cap256-119-137881; anti-HIV_cap256-119-137643;anti-HIV_cap256-119-137170; anti-HIV_cap256-119-136616;anti-HIV_cap256-119-136206; anti-HIV_cap256-119-135565;anti-HIV_cap256-119-135025; anti-HIV_cap256-119-133983;anti-HIV_cap256-119-133917; anti-HIV_cap256-119-132663;anti-HIV_cap256-119-132113; anti-HIV_cap256-119-131839;anti-HIV_cap256-119-130626; anti-HIV_cap256-119-130191;anti-HIV_cap256-119-129798; anti-HIV_cap256-119-128745;anti-HIV_cap256-119-128593; anti-HIV_cap256-119-128152;anti-HIV_cap256-119-127693; anti-HIV_cap256-119-126684;anti-HIV_cap256-119-126056; anti-HIV_cap256-119-125765;anti-HIV_cap256-119-125106; anti-HIV_cap256-119-124026;anti-HIV_cap256-119-121783; anti-HIV_cap256-119-121208;anti-HIV_cap256-119-120945; anti-HIV_cap256-119-118229;anti-HIV_cap256-119-118025; anti-HIV_cap256-119-117418;anti-HIV_cap256-119-117250; anti-HIV_cap256-119-117230;anti-HIV_cap256-119-116999; anti-HIV_cap256-119-116558;anti-HIV_cap256-119-116484; anti-HIV_cap256-119-114844;anti-HIV_cap256-119-114141; anti-HIV_cap256-119-111917;anti-HIV_cap256-119-111862; anti-HIV_cap256-119-110064;anti-HIV_cap256-119-109192; anti-HIV_cap256-119-108793;anti-HIV_cap256-119-108127; anti-HIV_cap256-119-107758;anti-HIV_cap256-119-107209; anti-HIV_cap256-119-107184;anti-HIV_cap256-119-106827; anti-HIV_cap256-119-106511;anti-HIV_cap256-119-106327; anti-HIV_cap256-119-105486;anti-HIV_cap256-119-105197; anti-HIV_cap256-119-104946;anti-HIV_cap256-119-103667; anti-HIV_cap256-119-103385;anti-HIV_cap256-119-103267; anti-HIV_cap256-119-103011;anti-HIV_cap256-119-102072; anti-HIV_cap256-119-101945;anti-HIV_cap256-119-101319; anti-HIV_cap256-119-100871;anti-HIV_cap256-119-100838; anti-HIV_cap256-119-100025;anti-HIV_cap256-119-100000; anti-HIV_cap256-119-098890;anti-HIV_cap256-119-098715; anti-HIV_cap256-119-098632;anti-HIV_cap256-119-097199; anti-HIV_cap256-119-096189;anti-HIV_cap256-119-094581; anti-HIV_cap256-119-094200;anti-HIV_cap256-119-094158; anti-HIV_cap256-119-092814;anti-HIV_cap256-119-092808; anti-HIV_cap256-119-092573;anti-HIV_cap256-119-090815; anti-HIV_cap256-119-090368;anti-HIV_cap256-119-089710; anti-HIV_cap256-119-088555;anti-HIV_cap256-119-087962; anti-HIV_cap256-119-086903;anti-HIV_cap256-119-086804; anti-HIV_cap256-119-085910;anti-HIV_cap256-119-085772; anti-HIV_cap256-119-084603;anti-HIV_cap256-119-084276; anti-HIV_cap256-119-082288;anti-HIV_cap256-119-080383; anti-HIV_cap256-119-079333;anti-HIV_cap256-119-078618; anti-HIV_cap256-119-077466;anti-HIV_cap256-119-076284; anti-HIV_cap256-119-074680;anti-HIV_cap256-119-074081; anti-HIV_cap256-119-071704;anti-HIV_cap256-119-071266; anti-HIV_cap256-119-069667;anti-HIV_cap256-119-069591; anti-HIV_cap256-119-068691;anti-HIV_cap256-119-068488; anti-HIV_cap256-119-067536;anti-HIV_cap256-119-065852; anti-HIV_cap256-119-065457;anti-HIV_cap256-119-064501; anti-HIV_cap256-119-063568;anti-HIV_cap256-119-063103; anti-HIV_cap256-119-061027;anti-HIV_cap256-119-058232; anti-HIV_cap256-119-057341;anti-HIV_cap256-119-056895; anti-HIV_cap256-119-056402;anti-HIV_cap256-119-056034; anti-HIV_cap256-119-055042;anti-HIV_cap256-119-054776; anti-HIV_cap256-119-054539;anti-HIV_cap256-119-054112; anti-HIV_cap256-119-053339;anti-HIV_cap256-119-052404; anti-HIV_cap256-119-051123;anti-HIV_cap256-119-051077; anti-HIV_cap256-119-050442;anti-HIV_cap256-119-049433; anti-HIV_cap256-119-047532;anti-HIV_cap256-119-047489; anti-HIV_cap256-119-046020;anti-HIV_cap256-119-044746; anti-HIV_cap256-119-044740;anti-HIV_cap256-119-043790; anti-HIV_cap256-119-042880;anti-HIV_cap256-119-042606; anti-HIV_cap256-119-042444;anti-HIV_cap256-119-040328; anti-HIV_cap256-119-040164;anti-HIV_cap256-119-039130; anti-HIV_cap256-119-038138;anti-HIV_cap256-119-037868; anti-HIV_cap256-119-037102;anti-HIV_cap256-119-036683; anti-HIV_cap256-119-036495;anti-HIV_cap256-119-035375; anti-HIV_cap256-119-035165;anti-HIV_cap256-119-035109; anti-HIV_cap256-119-033789;anti-HIV_cap256-119-033641; anti-HIV_cap256-119-032113;anti-HIV_cap256-119-031739; anti-HIV_cap256-119-030932;anti-HIV_cap256-119-030740; anti-HIV_cap256-119-030197;anti-HIV_cap256-119-027047; anti-HIV_cap256-119-026950;anti-HIV_cap256-119-026279; anti-HIV_cap256-119-025355;anti-HIV_cap256-119-025301; anti-HIV_cap256-119-025010;anti-HIV_cap256-119-024631; anti-HIV_cap256-119-024467;anti-HIV_cap256-119-023805; anti-HIV_cap256-119-021736;anti-HIV_cap256-119-021203; anti-HIV_cap256-119-020569;anti-HIV_cap256-119-019432; anti-HIV_cap256-119-018827;anti-HIV_cap256-119-018483; anti-HIV_cap256-119-018118;anti-HIV_cap256-119-017782; anti-HIV_cap256-119-017669;anti-HIV_cap256-119-016976; anti-HIV_cap256-119-015432;anti-HIV_cap256-119-015281; anti-HIV_cap256-119-014957;anti-HIV_cap256-119-014777; anti-HIV_cap256-119-014313;anti-HIV_cap256-119-014219; anti-HIV_cap256-119-013631;anti-HIV_cap256-119-012924; anti-HIV_cap256-119-011793;anti-HIV_cap256-119-011413; anti-HIV_cap256-119-011323;anti-HIV_cap256-119-011233; anti-HIV_cap256-119-009038;anti-HIV_cap256-119-008756; anti-HIV_cap256-119-008055;anti-HIV_cap256-119-006949; anti-HIV_cap256-119-006685;anti-HIV_cap256-119-006015; anti-HIV_cap256-119-005841;anti-HIV_cap256-119-005824; anti-HIV_cap256-119-005494;anti-HIV_cap256-119-004949; anti-HIV_cap256-119-004422;anti-HIV_cap256-119-003932; anti-HIV_cap256-119-003577;anti-HIV_cap256-119-002155; anti-HIV_cap256-119-002017;anti-HIV_cap256-119-001312; anti-HIV_cap256-119-001017;anti-HIV_cap256-119-000594; anti-HIV_cap256-059-241099;anti-HIV_cap256-059-207529; anti-HIV_cap256-059-205541;anti-HIV_cap256-059-188439; anti-HIV_cap256-059-187234;anti-HIV_cap256-059-187047; anti-HIV_cap256-059-186068;anti-HIV_cap256-059-182835; anti-HIV_cap256-059-176659;anti-HIV_cap256-059-172956; anti-HIV_cap256-059-171272;anti-HIV_cap256-059-168734; anti-HIV_cap256-059-155838;anti-HIV_cap256-059-149799; anti-HIV_cap256-059-148168;anti-HIV_cap256-059-144685; anti-HIV_cap256-059-140017;anti-HIV_cap256-059-137547; anti-HIV_cap256-059-131908;anti-HIV_cap256-059-116006; anti-HIV_cap256-059-115783;anti-HIV_cap256-059-114609; anti-HIV_cap256-059-113952;anti-HIV_cap256-059-113878; anti-HIV_cap256-059-113622;anti-HIV_cap256-059-109427; anti-HIV_cap256-059-109081;anti-HIV_cap256-059-107590; anti-HIV_cap256-059-107504;anti-HIV_cap256-059-099614; anti-HIV_cap256-059-098972;anti-HIV_cap256-059-097236; anti-HIV_cap256-059-091487;anti-HIV_cap256-059-089812; anti-HIV_cap256-059-088468;anti-HIV_cap256-059-088341; anti-HIV_cap256-059-086533;anti-HIV_cap256-059-086043; anti-HIV_cap256-059-084191;anti-HIV_cap256-059-082135; anti-HIV_cap256-059-079417;anti-HIV_cap256-059-076027; anti-HIV_cap256-059-075082;anti-HIV_cap256-059-072575; anti-HIV_cap256-059-071926;anti-HIV_cap256-059-069638; anti-HIV_cap256-059-069165;anti-HIV_cap256-059-068956; anti-HIV_cap256-059-068876;anti-HIV_cap256-059-067733; anti-HIV_cap256-059-067450;anti-HIV_cap256-059-065694; anti-HIV_cap256-059-065109;anti-HIV_cap256-059-065060; anti-HIV_cap256-059-064001;anti-HIV_cap256-059-063270; anti-HIV_cap256-059-061357;anti-HIV_cap256-059-059834; anti-HIV_cap256-059-059313;anti-HIV_cap256-059-057130; anti-HIV_cap256-059-050520;anti-HIV_cap256-059-049839; anti-HIV_cap256-059-048503;anti-HIV_cap256-059-045516; anti-HIV_cap256-059-044188;anti-HIV_cap256-059-044105; anti-HIV_cap256-059-042100;anti-HIV_cap256-059-040742; anti-HIV_cap256-059-040554;anti-HIV_cap256-059-039660; anti-HIV_cap256-059-039298;anti-HIV_cap256-059-037873; anti-HIV_cap256-059-037633;anti-HIV_cap256-059-036817; anti-HIV_cap256-059-032787;anti-HIV_cap256-059-032427; anti-HIV_cap256-059-029390;anti-HIV_cap256-059-027877; anti-HIV_cap256-059-026640;anti-HIV_cap256-059-026017; anti-HIV_cap256-059-024100;anti-HIV_cap256-059-023966; anti-HIV_cap256-059-020534;anti-HIV_cap256-059-019513; anti-HIV_cap256-059-012963;anti-HIV_cap256-059-010396; anti-HIV_cap256-059-008136;anti-HIV_cap256-059-006147; anti-HIV_cap256-059-005081;anti-HIV_cap256-059-005006; anti-HIV_cap256-059-004451;anti-HIV_cap256-059-003571; anti-HIV_cap256-059-003449;anti-HIV_cap256-059-002712; anti-HIV_cap256-059-001573;anti-HIV_cap256-059-001379; anti-HIV_cap256-059-001029;anti-HIV_cap256-048-165087; anti-HIV_cap256-048-158861;anti-HIV_cap256-048-158280; anti-HIV_cap256-048-157928;anti-HIV_cap256-048-157056; anti-HIV_cap256-048-156422;anti-HIV_cap256-048-152863; anti-HIV_cap256-048-152770;anti-HIV_cap256-048-150027; anti-HIV_cap256-048-148246;anti-HIV_cap256-048-147428; anti-HIV_cap256-048-146603;anti-HIV_cap256-048-145735; anti-HIV_cap256-048-145116;anti-HIV_cap256-048-144077; anti-HIV_cap256-048-142876;anti-HIV_cap256-048-140582; anti-HIV_cap256-048-139355;anti-HIV_cap256-048-139151; anti-HIV_cap256-048-137672;anti-HIV_cap256-048-137506; anti-HIV_cap256-048-137270;anti-HIV_cap256-048-135447; anti-HIV_cap256-048-131966;anti-HIV_cap256-048-131008; anti-HIV_cap256-048-129369;anti-HIV_cap256-048-128476; anti-HIV_cap256-048-128270;anti-HIV_cap256-048-126220; anti-HIV_cap256-048-125713;anti-HIV_cap256-048-123934; anti-HIV_cap256-048-122673;anti-HIV_cap256-048-122208; anti-HIV_cap256-048-121552;anti-HIV_cap256-048-120643; anti-HIV_cap256-048-118458;anti-HIV_cap256-048-118112; anti-HIV_cap256-048-116469;anti-HIV_cap256-048-113917; anti-HIV_cap256-048-112368;anti-HIV_cap256-048-112047; anti-HIV_cap256-048-112029;anti-HIV_cap256-048-110957; anti-HIV_cap256-048-110526;anti-HIV_cap256-048-109336; anti-HIV_cap256-048-108152;anti-HIV_cap256-048-107799; anti-HIV_cap256-048-107384;anti-HIV_cap256-048-106530; anti-HIV_cap256-048-106464;anti-HIV_cap256-048-106411; anti-HIV_cap256-048-106306;anti-HIV_cap256-048-104496; anti-HIV_cap256-048-103074;anti-HIV_cap256-048-100832; anti-HIV_cap256-048-100188;anti-HIV_cap256-048-099645; anti-HIV_cap256-048-098137;anti-HIV_cap256-048-097878; anti-HIV_cap256-048-097510;anti-HIV_cap256-048-097313; anti-HIV_cap256-048-096626;anti-HIV_cap256-048-096483; anti-HIV_cap256-048-095691;anti-HIV_cap256-048-095525; anti-HIV_cap256-048-094783;anti-HIV_cap256-048-094356; anti-HIV_cap256-048-090756;anti-HIV_cap256-048-089065; anti-HIV_cap256-048-084986;anti-HIV_cap256-048-083355; anti-HIV_cap256-048-082462;anti-HIV_cap256-048-082246; anti-HIV_cap256-048-080752;anti-HIV_cap256-048-078409; anti-HIV_cap256-048-078273;anti-HIV_cap256-048-078062; anti-HIV_cap256-048-077798;anti-HIV_cap256-048-073853; anti-HIV_cap256-048-071661;anti-HIV_cap256-048-071360; anti-HIV_cap256-048-070955;anti-HIV_cap256-048-070061; anti-HIV_cap256-048-069669;anti-HIV_cap256-048-069205; anti-HIV_cap256-048-068882;anti-HIV_cap256-048-067764; anti-HIV_cap256-048-066845;anti-HIV_cap256-048-065226; anti-HIV_cap256-048-063717;anti-HIV_cap256-048-063150; anti-HIV_cap256-048-062431;anti-HIV_cap256-048-060745; anti-HIV_cap256-048-060420;anti-HIV_cap256-048-060014; anti-HIV_cap256-048-059747;anti-HIV_cap256-048-058393; anti-HIV_cap256-048-058159;anti-HIV_cap256-048-057127; anti-HIV_cap256-048-056251;anti-HIV_cap256-048-055421; anti-HIV_cap256-048-054989;anti-HIV_cap256-048-054759; anti-HIV_cap256-048-052573;anti-HIV_cap256-048-051477; anti-HIV_cap256-048-051299;anti-HIV_cap256-048-050815; anti-HIV_cap256-048-049884;anti-HIV_cap256-048-049170; anti-HIV_cap256-048-048531;anti-HIV_cap256-048-048259; anti-HIV_cap256-048-047313;anti-HIV_cap256-048-046596; anti-HIV_cap256-048-044781;anti-HIV_cap256-048-042599; anti-HIV_cap256-048-041276;anti-HIV_cap256-048-040200; anti-HIV_cap256-048-039061;anti-HIV_cap256-048-038515; anti-HIV_cap256-048-038255;anti-HIV_cap256-048-038177; anti-HIV_cap256-048-035513;anti-HIV_cap256-048-034112; anti-HIV_cap256-048-033983;anti-HIV_cap256-048-032688; anti-HIV_cap256-048-031092;anti-HIV_cap256-048-030464; anti-HIV_cap256-048-030289;anti-HIV_cap256-048-030261; anti-HIV_cap256-048-029362;anti-HIV_cap256-048-027638; anti-HIV_cap256-048-027613;anti-HIV_cap256-048-026627; anti-HIV_cap256-048-026239;anti-HIV_cap256-048-025518; anti-HIV_cap256-048-024854;anti-HIV_cap256-048-024537; anti-HIV_cap256-048-021781;anti-HIV_cap256-048-021758; anti-HIV_cap256-048-020988;anti-HIV_cap256-048-020663; anti-HIV_cap256-048-020590;anti-HIV_cap256-048-019765; anti-HIV_cap256-048-019254;anti-HIV_cap256-048-018073; anti-HIV_cap256-048-016775;anti-HIV_cap256-048-016069; anti-HIV_cap256-048-015867;anti-HIV_cap256-048-015673; anti-HIV_cap256-048-015156;anti-HIV_cap256-048-014521; anti-HIV_cap256-048-014475;anti-HIV_cap256-048-013798; anti-HIV_cap256-048-013271;anti-HIV_cap256-048-013180; anti-HIV_cap256-048-012148;anti-HIV_cap256-048-011870; anti-HIV_cap256-048-011530;anti-HIV_cap256-048-010968; anti-HIV_cap256-048-010224;anti-HIV_cap256-048-009749; anti-HIV_cap256-048-009623;anti-HIV_cap256-048-008234; anti-HIV_cap256-048-008149;anti-HIV_cap256-048-007301; anti-HIV_cap256-048-007174;anti-HIV_cap256-048-007079; anti-HIV_cap256-048-007033;anti-HIV_cap256-048-006128; anti-HIV_cap256-048-005999;anti-HIV_cap256-048-005394; anti-HIV_cap256-048-004226;anti-HIV_cap256-048-004097; anti-HIV_cap256-048-003289;anti-HIV_cap256-048-002601; anti-HIV_cap256-048-002129;anti-HIV_cap256-048-001875; anti-HIV_cap256-048-001302;anti-HIV_cap256-048-001203; anti-HIV_cap256-048-000383;anti-HIV_cap256-038-261791; anti-HIV_cap256-038-241540;anti-HIV_cap256-038-235677; anti-HIV_cap256-038-234314;anti-HIV_cap256-038-234273; anti-HIV_cap256-038-223164;anti-HIV_cap256-038-220289; anti-HIV_cap256-038-220020;anti-HIV_cap256-038-216853; anti-HIV_cap256-038-213466;anti-HIV_cap256-038-213212; anti-HIV_cap256-038-213120;anti-HIV_cap256-038-212592; anti-HIV_cap256-038-211790;anti-HIV_cap256-038-209916; anti-HIV_cap256-038-207938;anti-HIV_cap256-038-202245; anti-HIV_cap256-038-197721;anti-HIV_cap256-038-196679; anti-HIV_cap256-038-196118;anti-HIV_cap256-038-195382; anti-HIV_cap256-038-180001;anti-HIV_cap256-038-178021; anti-HIV_cap256-038-177104;anti-HIV_cap256-038-171261; anti-HIV_cap256-038-169090;anti-HIV_cap256-038-168705; anti-HIV_cap256-038-167685;anti-HIV_cap256-038-158775; anti-HIV_cap256-038-157318;anti-HIV_cap256-038-153058; anti-HIV_cap256-038-150027;anti-HIV_cap256-038-146372; anti-HIV_cap256-038-141868;anti-HIV_cap256-038-141616; anti-HIV_cap256-038-127989;anti-HIV_cap256-038-118109; anti-HIV_cap256-038-112226;anti-HIV_cap256-038-105918; anti-HIV_cap256-038-104487;anti-HIV_cap256-038-102308; anti-HIV_cap256-038-091115;anti-HIV_cap256-038-090262; anti-HIV_cap256-038-083260;anti-HIV_cap256-038-080981; anti-HIV_cap256-038-080873;anti-HIV_cap256-038-074413; anti-HIV_cap256-038-073153;anti-HIV_cap256-038-064227; anti-HIV_cap256-038-061640;anti-HIV_cap256-038-059482; anti-HIV_cap256-038-054000;anti-HIV_cap256-038-050554; anti-HIV_cap256-038-044256;anti-HIV_cap256-038-040944; anti-HIV_cap256-038-040090;anti-HIV_cap256-038-032874; anti-HIV_cap256-038-025899;anti-HIV_cap256-038-024581; anti-HIV_cap256-038-013345;anti-HIV_cap256-038-011559; anti-HIV_cap256-038-009634;anti-HIV_cap256-038-006730; anti-HIV_cap256-038-004887;anti-HIV_cap256-038-004840; anti-HIV_cap256-038-002181;anti-HIV_cap256-038-001902; anti-HIV_cap256-038-000976;anti-HIV_cap256-038-000384; anti-HIV_cap206-314431; anti-HIV_206-247594;anti-HIV_206-116890; anti-HIV_206-072383; anti-HIV_206-037527;anti-HIV_206-009095; anti-HIV_176-503620; anti-HIV_176-478726;anti-HIV_176-245056; anti-HIV_176-164413; anti-HIV_176-094308;anti-HIV_176-065321; anti-HIV_119-099719; anti-HIV_119-099536;anti-HIV_119-098907; anti-HIV_119-098555; anti-HIV_119-097828;anti-HIV_119-096480; anti-HIV_119-095664; anti-HIV_119-095212;anti-HIV_119-094773; anti-HIV_119-094508; anti-HIV_119-093795;anti-HIV_119-093732; anti-HIV_119-092903; anti-HIV_119-092284;anti-HIV_119-091586; anti-HIV_119-091023; anti-HIV_119-090334;anti-HIV_119-088694; anti-HIV_119-088499; anti-HIV_119-088298;anti-HIV_119-087488; anti-HIV_119-087423; anti-HIV_119-087371;anti-HIV_119-087279; anti-HIV_119-087146; anti-HIV_119-087048;anti-HIV_119-085802; anti-HIV_119-085784; anti-HIV_119-085370;anti-HIV_119-085276; anti-HIV_119-084885; anti-HIV_119-084874;anti-HIV_119-084691; anti-HIV_119-083793; anti-HIV_119-083163;anti-HIV_119-082331; anti-HIV_119-082070; anti-HIV_119-081512;anti-HIV_119-080816; anti-HIV_119-079302; anti-HIV_119-079292;anti-HIV_119-079289; anti-HIV_119-078935; anti-HIV_119-078702;anti-HIV_119-078593; anti-HIV_119-077708; anti-HIV_119-076904;anti-HIV_119-075862; anti-HIV_119-075465; anti-HIV_119-074822;anti-HIV_119-074629; anti-HIV_119-074500; anti-HIV_119-073911;anti-HIV_119-072765; anti-HIV_119-072313; anti-HIV_119-072280;anti-HIV_119-071693; anti-HIV_119-071353; anti-HIV_119-069711;anti-HIV_119-069061; anti-HIV_119-068202; anti-HIV_119-068063;anti-HIV_119-067980; anti-HIV_119-067866; anti-HIV_119-067756;anti-HIV_119-066859; anti-HIV_119-065821; anti-HIV_119-065191;anti-HIV_119-064667; anti-HIV_119-063791; anti-HIV_119-062989;anti-HIV_119-062286; anti-HIV_119-061416; anti-HIV_119-061344;anti-HIV_119-060240; anti-HIV_119-060184; anti-HIV_119-058035;anti-HIV_119-057858; anti-HIV_119-057473; anti-HIV_119-057090;anti-HIV_119-055754; anti-HIV_119-054899; anti-HIV_119-054501;anti-HIV_119-051867; anti-HIV_119-051814; anti-HIV_119-051567;anti-HIV_119-051483; anti-HIV_119-050913; anti-HIV_119-050187;anti-HIV_119-049069; anti-HIV_119-048517; anti-HIV_119-048470;anti-HIV_119-048303; anti-HIV_119-048021; anti-HIV_119-047928;anti-HIV_119-047384; anti-HIV_119-047145; anti-HIV_119-046752;anti-HIV_119-046660; anti-HIV_119-046202; anti-HIV_119-045790;anti-HIV_119-044670; anti-HIV_119-044140; anti-HIV_119-042776;anti-HIV_119-042581; anti-HIV_119-040905; anti-HIV_119-040322;anti-HIV_119-039892; anti-HIV_119-039764; anti-HIV_119-039188;anti-HIV_119-039058; anti-HIV_119-038837; anti-HIV_119-038396;anti-HIV_119-036918; anti-HIV_119-036592; anti-HIV_119-036310;anti-HIV_119-035618; anti-HIV_119-035569; anti-HIV_119-035466;anti-HIV_119-035157; anti-HIV_119-035121; anti-HIV_119-035046;anti-HIV_119-034754; anti-HIV_119-034318; anti-HIV_119-033780;anti-HIV_119-033632; anti-HIV_119-033183; anti-HIV_119-030696;anti-HIV_119-030059; anti-HIV_119-029589; anti-HIV_119-029448;anti-HIV_119-029220; anti-HIV_119-028317; anti-HIV_119-028165;anti-HIV_119-027147; anti-HIV_119-026743; anti-HIV_119-026508;anti-HIV_119-025683; anti-HIV_119-025614; anti-HIV_119-025548;anti-HIV_119-025526; anti-HIV_119-023552; anti-HIV_119-023092;anti-HIV_119-022793; anti-HIV_119-022395; anti-HIV_119-022334;anti-HIV_119-021866; anti-HIV_119-021278; anti-HIV_119-021183;anti-HIV_119-019376; anti-HIV_119-019238; anti-HIV_119-018500;anti-HIV_119-018318; anti-HIV_119-018218; anti-HIV_119-017876;anti-HIV_119-017740; anti-HIV_119-017128; anti-HIV_119-017044;anti-HIV_119-016644; anti-HIV_119-015878; anti-HIV_119-015538;anti-HIV_119-015455; anti-HIV_119-014425; anti-HIV_119-013582;anti-HIV_119-013364; anti-HIV_119-012886; anti-HIV_119-012249;anti-HIV_119-012161; anti-HIV_119-012110; anti-HIV_119-012100;anti-HIV_119-011651; anti-HIV_119-011479; anti-HIV_119-011232;anti-HIV_119-011175; anti-HIV_119-008396; anti-HIV_119-007148;anti-HIV_119-007029; anti-HIV_119-004707; anti-HIV_119-003910;anti-HIV_119-002450; anti-HIV_119-001552; anti-HIV_059-188169;anti-HIV_059-183739; anti-HIV_059-182376; anti-HIV_059-182199;anti-HIV_059-169202; anti-HIV_059-155645; anti-HIV_059-151619;anti-HIV_059-146503; anti-HIV_059-136098; anti-HIV_059-105516;anti-HIV_059-095709; anti-HIV_059-069468; anti-HIV_059-060026;anti-HIV_059-053668; anti-HIV_059-052864; anti-HIV_059-050968;anti-HIV_059-046422; anti-HIV_059-045120; anti-HIV_059-039932;anti-HIV_059-038595; anti-HIV_059-035082; anti-HIV_059-029204;anti-HIV_059-025235; anti-HIV_059-015192; anti-HIV_059-007060;anti-HIV_059-006953; anti-HIV_059-005953; anti-HIV_059-003725;anti-HIV_059-002618; anti-HIV_059-001522; anti-HIV_059-000731;anti-HIV_059-000634; anti-HIV_048-250757; anti-HIV_048-250716;anti-HIV_048-250463; anti-HIV_048-248153; anti-HIV_048-247532;anti-HIV_048-245846; anti-HIV_048-244016; anti-HIV_048-243682;anti-HIV_048-243588; anti-HIV_048-241775; anti-HIV_048-237996;anti-HIV_048-237730; anti-HIV_048-237253; anti-HIV_048-234100;anti-HIV_048-230882; anti-HIV_048-229473; anti-HIV_048-228238;anti-HIV_048-228027; anti-HIV_048-227795; anti-HIV_048-227770;anti-HIV_048-225298; anti-HIV_048-225090; anti-HIV_048-224187;anti-HIV_048-223055; anti-HIV_048-222711; anti-HIV_048-221209;anti-HIV_048-220629; anti-HIV_048-219430; anti-HIV_048-216250;anti-HIV_048-216133; anti-HIV_048-214886; anti-HIV_048-214709;anti-HIV_048-214001; anti-HIV_048-213230; anti-HIV_048-212574;anti-HIV_048-212207; anti-HIV_048-209146; anti-HIV_048-208206;anti-HIV_048-208194; anti-HIV_048-207744; anti-HIV_048-206501;anti-HIV_048-204221; anti-HIV_048-204015; anti-HIV_048-201240;anti-HIV_048-200455; anti-HIV_048-200319; anti-HIV_048-197896;anti-HIV_048-193813; anti-HIV_048-192098; anti-HIV_048-191786;anti-HIV_048-188746; anti-HIV_048-185937; anti-HIV_048-184849;anti-HIV_048-183089; anti-HIV_048-181509; anti-HIV_048-180990;anti-HIV_048-177532; anti-HIV_048-177426; anti-HIV_048-177389;anti-HIV_048-174266; anti-HIV_048-172847; anti-HIV_048-172845;anti-HIV_048-172363; anti-HIV_048-171609; anti-HIV_048-170705;anti-HIV_048-168381; anti-HIV_048-166619; anti-HIV_048-162036;anti-HIV_048-160042; anti-HIV_048-159676; anti-HIV_048-159500;anti-HIV_048-159421; anti-HIV_048-159333; anti-HIV_048-158932;anti-HIV_048-155811; anti-HIV_048-155464; anti-HIV_048-155392;anti-HIV_048-155389; anti-HIV_048-154449; anti-HIV_048-153379;anti-HIV_048-153171; anti-HIV_048-152324; anti-HIV_048-146102;anti-HIV_048-145984; anti-HIV_048-145371; anti-HIV_048-144907;anti-HIV_048-142298; anti-HIV_048-142277; anti-HIV_048-141934;anti-HIV_048-141207; anti-HIV_048-140796; anti-HIV_048-139893;anti-HIV_048-138820; anti-HIV_048-135858; anti-HIV_048-134968;anti-HIV_048-134312; anti-HIV_048-132253; anti-HIV_048-130710;anti-HIV_048-128564; anti-HIV_048-126702; anti-HIV_048-124521;anti-HIV_048-122740; anti-HIV_048-119536; anti-HIV_048-116929;anti-HIV_048-116577; anti-HIV_048-116046; anti-HIV_048-115875;anti-HIV_048-115599; anti-HIV_048-113988; anti-HIV_048-112989;anti-HIV_048-112435; anti-HIV_048-111339; anti-HIV_048-111055;anti-HIV_048-111027; anti-HIV_048-109721; anti-HIV_048-109666;anti-HIV_048-109196; anti-HIV_048-109051; anti-HIV_048-108570;anti-HIV_048-108033; anti-HIV_048-107279; anti-HIV_048-106271;anti-HIV_048-106054; anti-HIV_048-104848; anti-HIV_048-104638;anti-HIV_048-104567; anti-HIV_048-102804; anti-HIV_048-101676;anti-HIV_048-097603; anti-HIV_048-097107; anti-HIV_048-096871;anti-HIV_048-096668; anti-HIV_048-095236; anti-HIV_048-094155;anti-HIV_048-093219; anti-HIV_048-092976; anti-HIV_048-090866;anti-HIV_048-090650; anti-HIV_048-089009; anti-HIV_048-088654;anti-HIV_048-086513; anti-HIV_048-086024; anti-HIV_048-085857;anti-HIV_048-084277; anti-HIV_048-084245; anti-HIV_048-082487;anti-HIV_048-081787; anti-HIV_048-081062; anti-HIV_048-079639;anti-HIV_048-079126; anti-HIV_048-073118; anti-HIV_048-070264;anti-HIV_048-069426; anti-HIV_048-068564; anti-HIV_048-068345;anti-HIV_048-067337; anti-HIV_048-067180; anti-HIV_048-063017;anti-HIV_048-061885; anti-HIV_048-061671; anti-HIV_048-060700;anti-HIV_048-060592; anti-HIV_048-060300; anti-HIV_048-059141;anti-HIV_048-057777; anti-HIV_048-056928; anti-HIV_048-056131;anti-HIV_048-055864; anti-HIV_048-055094; anti-HIV_048-054343;anti-HIV_048-054193; anti-HIV_048-052521; anti-HIV_048-049037;anti-HIV_048-048720; anti-HIV_048-048542; anti-HIV_048-047777;anti-HIV_048-046841; anti-HIV_048-046202; anti-HIV_048-046059;anti-HIV_048-043568; anti-HIV_048-042713; anti-HIV_048-042440;anti-HIV_048-040511; anti-HIV_048-039195; anti-HIV_048-036935;anti-HIV_048-034478; anti-HIV_048-031641; anti-HIV_048-029760;anti-HIV_048-027970; anti-HIV_048-027337; anti-HIV_048-027217;anti-HIV_048-026760; anti-HIV_048-024800; anti-HIV_048-024313;anti-HIV_048-021748; anti-HIV_048-020991; anti-HIV_048-020340;anti-HIV_048-019993; anti-HIV_048-019947; anti-HIV_048-017871;anti-HIV_048-015931; anti-HIV_048-015920; anti-HIV_048-013898;anti-HIV_048-013429; anti-HIV_048-012358; anti-HIV_048-011158;anti-HIV_048-010720; anti-HIV_048-009445; anti-HIV_048-006126;anti-HIV_048-005652; anti-HIV_048-005532; anti-HIV_048-005189;anti-HIV_048-005088; anti-HIV_048-004023; anti-HIV_048-001580;anti-HIV_038-221120; anti-HIV_038-197677; anti-HIV_038-196765;anti-HIV_038-186200; anti-HIV_038-126170; anti-HIV_038-108545;anti-HIV_038-107263; anti-HIV_038-104530; anti-HIV_038-099169;anti-HIV_038-075067; anti-HIV_038-072368; anti-HIV_038-068503;anti-HIV_038-068016; anti-HIV_038-063958; anti-HIV_038-033733;anti-HIV_038-030557; anti-HIV_038-024298; anti-HIV_038-011154;anti-HIV_5CIN; anti-HIV_5CIL; anti-HIV_5CIP; anti-HIV_4JKP;anti-HIV_3TNN; anti-HIV_3BQU; anti-HIV_IgG; anti-HIV_4P9M;anti-HIV_4P9H; anti-HIV_Ig; anti-HIV; anti-influenza;anti-influenza_Apo; anti-influenza-A; anti-OX40; or a fragment orvariant thereof.

More preferably, the at least one coding sequence of the RNA accordingto the present invention encodes an antibody or a fragment or variantthereof comprising an amino acid sequence selected from the groupconsisting of amino acid sequences according to SEQ ID NOs: 1-7642,61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281,61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357,61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426,61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476,61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516,61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573,61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619,61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675,61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, and61730; or a fragment or variant of any one of said amino acid sequences.

According to certain preferred embodiments of the present invention, theRNA is mono-, bi-, or multicistronic as defined herein. The codingsequences in a bi- or multicistronic RNA preferably encode distinctantibodies as defined herein or distinct fragments or variants thereof.In particular, an RNA according to the present invention preferablyencodes a full-length (complete) antibody in a multicistronic manner,e.g. by encoding the heavy chain (or a fragment thereof, e.g. the heavychain variable region) and the light chain (or a fragment thereof, e.g.the light chain variable region) of the same antibody in separatecistrons on one single RNA (molecule). Accordingly, the RNA according tothe present invention is preferably bicistronic or multicistronic.However, it is also preferred that the RNA according to the presentinvention is monocistronic. For example, a full-length (complete)antibody may be encoded in one single cistron, e.g. if the heavy chain(or a fragment thereof, e.g. the heavy chain variable region) and thelight chain (or a fragment thereof, e.g. the light chain variableregion) are connected via a peptidic linker (linker sequence) asdescribed below. A monocistronic RNA according to the present inventionmay also encode only a fragment of an antibody, in particular the heavychain (or a fragment thereof, e.g. the heavy chain variable region)only, or the light chain (or a fragment thereof, e.g. the light chainvariable region) only—with the corresponding the heavy chain (or afragment thereof, e.g. the heavy chain variable region) or the lightchain (or a fragment thereof, e.g. the light chain variable region)being encoded (preferably in a similar monocistronic manner) by anotherRNA (molecule). This embodiment is in particular preferred in thecontext of a combination of RNA's according to the present invention asdescribed herein.

Preferably, the coding sequences encoding two or more antibodies orfragments thereof may be separated in the bi- or multicistronic RNA byat least one IRES (internal ribosomal entry site) sequence, as definedbelow. Thus, the term “encoding two or more antibodies or fragmentsthereof” may mean, without being limited thereto, that the bi- or evenmulticistronic RNA, may encode e.g. at least two, three, four, five, sixor more (preferably different) antibodies or fragments thereof of theantibodies or their fragments within the definitions provided herein.More preferably, without being limited thereto, the bi- or evenmulticistronic mRNA, may encode, for example, at least two, three, four,five, six or more (preferably different) antibodies as defined herein ortheir fragments or variants as defined herein. In this context, aso-called IRES (internal ribosomal entry site) sequence as defined abovecan function as a sole ribosome binding site, but it can also serve toprovide a bi- or even multicistronic mRNA as defined above, whichencodes several antibodies, which are to be translated by the ribosomesindependently of one another. Examples of IRES sequences, which can beused according to the invention, are those from picornaviruses (e.g.FMDV), pestiviruses (CFFV), polioviruses (PV), encephalomyocarditisviruses (ECMV), foot and mouth disease viruses (FMDV), hepatitis Cviruses (HCV), classical swine fever viruses (CSFV), mouse leukoma virus(MLV), simian immunodeficiency viruses (SIV) or cricket paralysisviruses (CrPV).

According to a further embodiment the at least one coding sequence ofthe RNA according to the invention may encode at least two, three, four,five, six, seven, eight and more antibodies (or fragments or variantsthereof) as defined herein linked with or without an amino acid linkersequence, wherein said linker sequence can comprise rigid linkers,flexible linkers, cleavable linkers (e.g., self-cleaving peptides) or acombination thereof. Therein, the antibodies may be identical ordifferent or a combination thereof. Particular antibody combinations canbe encoded by said mRNA encoding at least two antibodies as explainedherein (also referred to herein as ‘multi-antibody-constructs/mRNA’). Inthis way the RNA according to the present invention may, for example,encode the heavy chain and the corresponding light chain of an antibody(such that one RNA molecule is sufficient to encode the completeantibody including heavy and light chain) or the heavy chain variableregion and the light chain variable region of an antibody (fragment).

Preferably, the at least one coding sequence of the RNA according to theinvention comprises at least two, three, four, five, six, seven, eightand more nucleic acid sequences having a sequence identity of at least5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%,90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of atleast 70%, more preferably of at least 80%, even more preferably atleast 85%, even more preferably of at least 90% and most preferably ofat least 95% or even 97%, with a nucleic acid sequence selected from thegroup consisting of SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211,61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302,61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380,61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436,61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473,61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514,61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563,61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607,61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642,61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687,61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729,61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322,61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404,61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428,61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473,61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520,61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608,61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733,and 61734; or a fragment or variant of any one of said nucleic acidsequences.

Preferably, the RNA comprising at least one coding sequence as definedherein typically comprises a length of about 50 to about 20000, or 100to about 20000 nucleotides, preferably of about 250 to about 20000nucleotides, more preferably of about 500 to about 10000, even morepreferably of about 500 to about 5000.

The RNA according to the invention may further be single stranded ordouble stranded. When provided as a double stranded RNA, the RNAaccording to the invention preferably comprises a sense and acorresponding antisense strand.

In a preferred embodiment, the RNA comprising at least one codingsequence as defined herein is an mRNA, a viral RNA or a replicon RNA.

According to a further embodiment, the RNA, preferably an mRNA,according to the invention is a modified RNA, preferably a modified RNAas described herein. In this context, a modification as defined hereinpreferably leads to a stabilization of the RNA according to theinvention. More preferably, the invention thus provides a stabilized RNAcomprising at least one coding sequence as defined herein.

According to one embodiment, the RNA of the present invention may thusbe provided as a “stabilized mRNA”, that is to say as an RNA that isessentially resistant to in vivo degradation (e.g. by an exo- orendo-nuclease). Such stabilization can be effected, for example, by amodified phosphate backbone of the RNA of the present invention. Abackbone modification in connection with the present invention is amodification in which phosphates of the backbone of the nucleotidescontained in the RNA are chemically modified. Nucleotides that may bepreferably used in this connection contain e.g. aphosphorothioate-modified phosphate backbone, preferably at least one ofthe phosphate oxygens contained in the phosphate backbone being replacedby a sulfur atom. Stabilized RNAs may further include, for example:non-ionic phosphate analogues, such as, for example, alkyl and arylphosphonates, in which the charged phosphonate oxygen is replaced by analkyl or aryl group, or phosphodiesters and alkylphosphotriesters, inwhich the charged oxygen residue is present in alkylated form. Suchbackbone modifications typically include, without implying anylimitation, modifications from the group consisting ofmethylphosphonates, phosphoramidates and phosphorothioates (e.g.cytidine-5′-O-(1-thiophosphate)).

In the following, specific modifications are described, which arepreferably capable of “stabilizing” the RNA as defined herein.

Chemical Modifications:

The term “RNA modification” as used herein may refer to chemicalmodifications comprising backbone modifications as well as sugarmodifications or base modifications.

In this context, a modified RNA as defined herein may contain nucleotideanalogues/modifications, e.g. backbone modifications, sugarmodifications or base modifications. A backbone modification inconnection with the present invention is a modification, in whichphosphates of the backbone of the nucleotides contained in an RNA asdefined herein are chemically modified. A sugar modification inconnection with the present invention is a chemical modification of thesugar of the nucleotides of the RNA as defined herein. Furthermore, abase modification in connection with the present invention is a chemicalmodification of the base moiety of the nucleotides of the RNA. In thiscontext, nucleotide analogues or modifications are preferably selectedfrom nucleotide analogues, which are applicable for transcription and/ortranslation.

Sugar Modifications:

The modified nucleosides and nucleotides, which may be incorporated intoa modified RNA as described herein, can be modified in the sugar moiety.For example, the 2′ hydroxyl group (OH) can be modified or replaced witha number of different “oxy” or “deoxy” substituents. Examples of“oxy”-2′ hydroxyl group modifications include, but are not limited to,alkoxy or aryloxy (—OR, e.g., R═H, alkyl, cycloalkyl, aryl, aralkyl,heteroaryl or sugar); polyethyleneglycols (PEG), —O(CH₂CH₂O)nCH₂CH₂OR;“locked” nucleic acids (LNA) in which the 2′ hydroxyl is connected,e.g., by a methylene bridge, to the 4′ carbon of the same ribose sugar;and amino groups (—O-amino, wherein the amino group, e.g., NRR, can bealkylamino, dialkylamino, heterocyclyl, arylamino, diarylamino,heteroarylamino, or diheteroaryl amino, ethylene diamine, polyamino) oraminoalkoxy.

“Deoxy” modifications include hydrogen, amino (e.g. NH₂; alkylamino,dialkylamino, heterocyclyl, arylamino, diaryl amino, heteroaryl amino,diheteroaryl amino, or amino acid); or the amino group can be attachedto the sugar through a linker, wherein the linker comprises one or moreof the atoms C, N, and O.

The sugar group can also contain one or more carbons that possess theopposite stereochemical configuration than that of the correspondingcarbon in ribose. Thus, a modified RNA can include nucleotidescontaining, for instance, arabinose as the sugar.

Backbone Modifications:

The phosphate backbone may further be modified in the modifiednucleosides and nucleotides, which may be incorporated into a modifiedRNA as described herein. The phosphate groups of the backbone can bemodified by replacing one or more of the oxygen atoms with a differentsubstituent. Further, the modified nucleosides and nucleotides caninclude the full replacement of an unmodified phosphate moiety with amodified phosphate as described herein. Examples of modified phosphategroups include, but are not limited to, phosphorothioate,phosphoroselenates, borano phosphates, borano phosphate esters, hydrogenphosphonates, phosphoroamidates, alkyl or aryl phosphonates andphosphotriesters. Phosphorodithioates have both non-linking oxygensreplaced by sulfur. The phosphate linker can also be modified by thereplacement of a linking oxygen with nitrogen (bridgedphosphoroamidates), sulfur (bridged phosphorothioates) and carbon(bridged methylene-phosphonates).

Base Modifications:

The modified nucleosides and nucleotides, which may be incorporated intoa modified RNA as described herein can further be modified in thenucleobase moiety. Examples of nucleobases found in RNA include, but arenot limited to, adenine, guanine, cytosine and uracil. For example, thenucleosides and nucleotides described herein can be chemically modifiedon the major groove face. In some embodiments, the major groove chemicalmodifications can include an amino group, a thiol group, an alkyl group,or a halo group.

In particularly preferred embodiments of the present invention, thenucleotide analogues/modifications are selected from base modifications,which are preferably selected from2-amino-6-chloropurineriboside-5′-triphosphate,2-Aminopurine-riboside-5′-triphosphate;2-aminoadenosine-5′-triphosphate,2′-Amino-2′-deoxycytidine-triphosphate, 2-thiocytidine-5′-triphosphate,2-thiouridine-5′-triphosphate, 2′-Fluorothymidine-5′-triphosphate,2′-0-Methyl-inosine-5′-triphosphate 4-thiouridine-5′-triphosphate,5-aminoallylcytidine-5′-triphosphate,5-aminoallyluridine-5′-triphosphate, 5-bromocytidine-5′-triphosphate,5-bromouridine-5′-triphosphate,5-Bromo-2′-deoxycytidine-5′-triphosphate,5-Bromo-2′-deoxyuridine-5′-triphosphate, 5-iodocytidine-5′-triphosphate,5-Iodo-2′-deoxycytidine-5′-triphosphate, 5-iodouridine-5′-triphosphate,5-Iodo-2′-deoxyuridine-5′-triphosphate,5-methylcytidine-5′-triphosphate, 5-methyluridine-5′-triphosphate,5-Propynyl-2′-deoxycytidine-5′-triphosphate,5-Propynyl-2′-deoxyuridine-5′-triphosphate,6-azacytidine-5′-triphosphate, 6-azauridine-5′-triphosphate,6-chloropurineriboside-5′-triphosphate,7-deazaadenosine-5′-triphosphate, 7-deazaguanosine-5′-triphosphate,8-azaadenosine-5′-triphosphate, 8-azidoadenosine-5′-triphosphate,benzimidazole-riboside-5′-triphosphate,N1-methyladenosine-5′-triphosphate, N1-methylguanosine-5′-triphosphate,N6-methyladenosine-5′-triphosphate, 06-methylguanosine-5′-triphosphate,pseudouridine-5′-triphosphate, or puromycin-5′-triphosphate,xanthosine-5′-triphosphate. Particular preference is given tonucleotides for base modifications selected from the group ofbase-modified nucleotides consisting of5-methylcytidine-5′-triphosphate, 7-deazaguanosine-5′-triphosphate,5-bromocytidine-5′-triphosphate, and pseudouridine-5′-triphosphate.

In some embodiments, modified nucleosides include pyridin-4-oneribonucleoside, 5-aza-uridine, 2-thio-5-aza-uridine, 2-thiouridine,4-thio-pseudouridine, 2-thio-pseudouridine, 5-hydroxyuridine,3-methyluridine, 5-carboxymethyl-uridine, 1-carboxymethyl-pseudouridine,5-propynyl-uridine, 1-propynyl-pseudouridine, 5-taurinomethyluridine,1-taurinomethyl-pseudouridine, 5-taurinomethyl-2-thio-uridine,1-taurinomethyl-4-thio-uridine, 5-methyl-uridine,1-methyl-pseudouridine, 4-thio-1-methyl-pseudouridine,2-thio-1-methyl-pseudouridine, 1-methyl-1-deaza-pseudouridine,2-thio-1-methyl-1-deaza-pseudouridine, dihydrouridine,dihydropseudouridine, 2-thio-dihydrouridine,2-thio-dihydropseudouridine, 2-methoxyuridine, 2-methoxy-4-thio-uridine,4-methoxy-pseudouridine, and 4-methoxy-2-thio-pseudouridine.

In some embodiments, modified nucleosides include 5-aza-cytidine,pseudoisocytidine, 3-methyl-cytidine, N4-acetylcytidine,5-formylcytidine, N4-methylcytidine, 5-hydroxymethylcytidine,1-methyl-pseudoisocytidine, pyrrolo-cytidine, pyrrolo-pseudoisocytidine,2-thio-cytidine, 2-thio-5-methyl-cytidine, 4-thio-pseudoisocytidine,4-thio-1-methyl-pseudoisocytidine,4-thio-1-methyl-1-deaza-pseudoisocytidine,1-methyl-1-deaza-pseudoisocytidine, zebularine, 5-aza-zebularine,5-methyl-zebularine, 5-aza-2-thio-zebularine, 2-thio-zebularine,2-methoxy-cytidine, 2-methoxy-5-methyl-cytidine,4-methoxy-pseudoisocytidine, and 4-methoxy-1-methyl-pseudoisocytidine.

In other embodiments, modified nucleosides include 2-aminopurine,2,6-diaminopurine, 7-deaza-adenine, 7-deaza-8-aza-adenine,7-deaza-2-aminopurine, 7-deaza-8-aza-2-aminopurine,7-deaza-2,6-diaminopurine, 7-deaza-8-aza-2,6-diaminopurine,1-methyladenosine, N6-methyladenosine, N6-isopentenyladenosine,N6-(cis-hydroxyisopentenyl)adenosine,2-methylthio-N6-(cis-hydroxyisopentenyl) adenosine,N6-glycinylcarbamoyladenosine, N6-threonylcarbamoyladenosine,2-methylthio-N6-threonyl carbamoyladenosine, N6,N6-dimethyladenosine,7-methyladenine, 2-methylthio-adenine, and 2-methoxy-adenine.

In other embodiments, modified nucleosides include inosine,1-methyl-inosine, wyosine, wybutosine, 7-deaza-guanosine,7-deaza-8-aza-guanosine, 6-thio-guanosine, 6-thio-7-deaza-guanosine,6-thio-7-deaza-8-aza-guanosine, 7-methyl-guanosine,6-thio-7-methyl-guanosine, 7-methylinosine, 6-methoxy-guanosine,1-methylguanosine, N2-methylguanosine, N2,N2-dimethylguanosine,8-oxo-guanosine, 7-methyl-8-oxo-guanosine, 1-methyl-6-thio-guanosine,N2-methyl-6-thio-guanosine, and N2,N2-dimethyl-6-thio-guanosine.

In some embodiments, the nucleotide can be modified on the major grooveface and can include replacing hydrogen on C-5 of uracil with a methylgroup or a halo group. In specific embodiments, a modified nucleoside is5′-O-(1-thiophosphate)-adenosine, 5′-O-(1-thiophosphate)-cytidine,5′-O-(1-thiophosphate)-guanosine, 5′-O-(1-thiophosphate)-uridine or5′-O-(1-thiophosphate)-pseudouridine.

In further specific embodiments, a modified RNA may comprise nucleosidemodifications selected from 6-aza-cytidine, 2-thio-cytidine,α-thio-cytidine, Pseudo-iso-cytidine, 5-aminoallyl-uridine,5-iodo-uridine, N1-methyl-pseudouridine, 5,6-dihydrouridine,α-thio-uridine, 4-thio-uridine, 6-aza-uridine, 5-hydroxy-uridine,deoxy-thymidine, 5-methyl-uridine, Pyrrolo-cytidine, inosine,α-thio-guanosine, 6-methyl-guanosine, 5-methyl-cytdine, 8-oxo-guanosine,7-deaza-guanosine, N1-methyl-adenosine, 2-amino-6-Chloro-purine,N6-methyl-2-amino-purine, Pseudo-iso-cytidine, 6-Chloro-purine,N6-methyl-adenosine, α-thio-adenosine, 8-azido-adenosine,7-deaza-adenosine.

Lipid Modification:

According to a further embodiment, a modified RNA as defined herein cancontain a lipid modification. Such a lipid-modified RNA typicallycomprises an RNA as defined herein. Such a lipid-modified RNA as definedherein typically further comprises at least one linker covalently linkedwith that RNA, and at least one lipid covalently linked with therespective linker. Alternatively, the lipid-modified RNA comprises atleast one RNA as defined herein and at least one (bifunctional) lipidcovalently linked (without a linker) with that RNA. According to a thirdalternative, the lipid-modified RNA comprises an RNA molecule as definedherein, at least one linker covalently linked with that RNA, and atleast one lipid covalently linked with the respective linker, and alsoat least one (bifunctional) lipid covalently linked (without a linker)with that RNA. In this context, it is particularly preferred that thelipid modification is present at the terminal ends of a linear RNAsequence.

G/C Content Modification:

According to another embodiment, the RNA of the present invention,preferably an mRNA, may be modified, and thus stabilized, by modifyingthe guanosine/cytosine (G/C) content of the RNA, preferably of the atleast one coding sequence of the RNA of the present invention.

In a particularly preferred embodiment of the present invention, the G/Ccontent of the coding region of the RNA of the present invention ismodified, particularly increased, compared to the G/C content of thecoding region of the respective wild-type RNA, i.e. the unmodified RNA.The amino acid sequence encoded by the RNA is preferably not modified ascompared to the amino acid sequence encoded by the respective wild-typeRNA. This modification of the RNA of the present invention is based onthe fact that the sequence of any RNA region to be translated isimportant for efficient translation of that RNA. Thus, the compositionof the RNA and the sequence of various nucleotides are important. Inparticular, sequences having an increased G (guanosine)/C (cytosine)content are more stable than sequences having an increased A(adenosine)/U (uracil) content. According to the invention, the codonsof the RNA are therefore varied compared to the respective wild-typeRNA, while retaining the translated amino acid sequence, such that theyinclude an increased amount of G/C nucleotides. In respect to the factthat several codons code for one and the same amino acid (so-calleddegeneration of the genetic code), the most favourable codons for thestability can be determined (so-called alternative codon usage).Depending on the amino acid to be encoded by the RNA, there are variouspossibilities for modification of the RNA sequence, compared to itswild-type sequence. In the case of amino acids, which are encoded bycodons, which contain exclusively G or C nucleotides, no modification ofthe codon is necessary. Thus, the codons for Pro (CCC or CCG), Arg (CGCor CGG), Ala (GCC or GCG) and Gly (GGC or GGG) require no modification,since no A or U is present. In contrast, codons which contain A and/or Unucleotides can be modified by substitution of other codons, which codefor the same amino acids but contain no A and/or U. Examples of theseare: the codons for Pro can be modified from CCU or CCA to CCC or CCG;the codons for Arg can be modified from CGU or CGA or AGA or AGG to CGCor CGG; the codons for Ala can be modified from GCU or GCA to GCC orGCG; the codons for Gly can be modified from GGU or GGA to GGC or GGG.In other cases, although A or U nucleotides cannot be eliminated fromthe codons, it is however possible to decrease the A and U content byusing codons which contain a lower content of A and/or U nucleotides.Examples of these are: the codons for Phe can be modified from UUU toUUC; the codons for Leu can be modified from UUA, UUG, CUU or CUA to CUCor CUG; the codons for Ser can be modified from UCU or UCA or AGU toUCC, UCG or AGC; the codon for Tyr can be modified from UAU to UAC; thecodon for Cys can be modified from UGU to UGC; the codon for His can bemodified from CAU to CAC; the codon for Gln can be modified from CAA toCAG; the codons for Ile can be modified from AUU or AUA to AUC; thecodons for Thr can be modified from ACU or ACA to ACC or ACG; the codonfor Asn can be modified from AAU to AAC; the codon for Lys can bemodified from AAA to AAG; the codons for Val can be modified from GUU orGUA to GUC or GUG; the codon for Asp can be modified from GAU to GAC;the codon for Glu can be modified from GAA to GAG; the stop codon UAAcan be modified to UAG or UGA. In the case of the codons for Met (AUG)and Trp (UGG), on the other hand, there is no possibility of sequencemodification. The substitutions listed above can be used eitherindividually or in all possible combinations to increase the G/C contentof the at least one mRNA of the composition of the present inventioncompared to its particular wild-type mRNA (i.e. the original sequence).Thus, for example, all codons for Thr occurring in the wild-typesequence can be modified to ACC (or ACG). Preferably, however, forexample, combinations of the above substitution possibilities are used:

substitution of all codons coding for Thr in the original sequence(wild-type mRNA) to ACC (or ACG) and

substitution of all codons originally coding for Ser to UCC (or UCG orAGC); substitution of all codons coding for Ile in the original sequenceto AUC and

substitution of all codons originally coding for Lys to AAG and

substitution of all codons originally coding for Tyr to UAC;substitution of all codons coding for Val in the original sequence toGUC (or GUG) and

substitution of all codons originally coding for Glu to GAG and

substitution of all codons originally coding for Ala to GCC (or GCG) and

substitution of all codons originally coding for Arg to CGC (or CGG);substitution of all codons coding for Val in the original sequence toGUC (or GUG) and

substitution of all codons originally coding for Glu to GAG and

substitution of all codons originally coding for Ala to GCC (or GCG) and

substitution of all codons originally coding for Gly to GGC (or GGG) and

substitution of all codons originally coding for Asn to AAC;substitution of all codons coding for Val in the original sequence toGUC (or GUG) and

substitution of all codons originally coding for Phe to UUC and

substitution of all codons originally coding for Cys to UGC and

substitution of all codons originally coding for Leu to CUG (or CUC) and

substitution of all codons originally coding for Gln to CAG and

substitution of all codons originally coding for Pro to CCC (or CCG);etc.

Preferably, the G/C content of the coding region of the RNA of thepresent invention is increased by at least 7%, more preferably by atleast 15%, particularly preferably by at least 20%, compared to the G/Ccontent of the coding region of the wild-type RNA, which codes for anantibody as defined herein or a fragment or variant thereof. Accordingto a specific embodiment at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, morepreferably at least 70%, even more preferably at least 80% and mostpreferably at least 90%, 95% or even 100% of the substitutable codons inthe region coding for an antibody as defined herein or a fragment orvariant thereof or the whole sequence of the wild type RNA sequence aresubstituted, thereby increasing the GC/content of said sequence. In thiscontext, it is particularly preferable to increase the G/C content ofthe RNA of the present invention, preferably of the at least one codingregion of the RNA according to the invention, to the maximum (i.e. 100%of the substitutable codons) as compared to the wild-type sequence.According to the invention, a further preferred modification of the RNAof the present invention is based on the finding that the translationefficiency is also determined by a different frequency in the occurrenceof tRNAs in cells. Thus, if so-called “rare codons” are present in theRNA of the present invention to an increased extent, the correspondingmodified RNA sequence is translated to a significantly poorer degreethan in the case where codons coding for relatively “frequent” tRNAs arepresent. According to the invention, in the modified RNA of the presentinvention, the region which codes for an antibody as defined herein or afragment or variant thereof is modified compared to the correspondingregion of the wild-type RNA such that at least one codon of thewild-type sequence, which codes for a tRNA which is relatively rare inthe cell, is exchanged for a codon, which codes for a tRNA which isrelatively frequent in the cell and carries the same amino acid as therelatively rare tRNA. By this modification, the sequences of the RNA ofthe present invention is modified such that codons for which frequentlyoccurring tRNAs are available are inserted. In other words, according tothe invention, by this modification all codons of the wild-typesequence, which code for a tRNA which is relatively rare in the cell,can in each case be exchanged for a codon, which codes for a tRNA whichis relatively frequent in the cell and which, in each case, carries thesame amino acid as the relatively rare tRNA. Which tRNAs occurrelatively frequently in the cell and which, in contrast, occurrelatively rarely is known to a person skilled in the art; cf. e.g.Akashi, Curr. Opin. Genet. Dev. 2001, 11(6): 660-666. The codons, whichuse for the particular amino acid the tRNA which occurs the mostfrequently, e.g. the Gly codon, which uses the tRNA, which occurs themost frequently in the (human) cell, are particularly preferred.According to the invention, it is particularly preferable to link thesequential G/C content which is increased, in particular maximized, inthe modified RNA of the present invention, with the “frequent” codonswithout modifying the amino acid sequence of the protein encoded by thecoding region of the RNA. This preferred embodiment allows provision ofa particularly efficiently translated and stabilized (modified) RNA ofthe present invention. The determination of a modified RNA of thepresent invention as described above (increased G/C content; exchange oftRNAs) can be carried out using the computer program explained in WO02/098443—the disclosure content of which is included in its full scopein the present invention. Using this computer program, the nucleotidesequence of any desired RNA can be modified with the aid of the geneticcode or the degenerative nature thereof such that a maximum G/C contentresults, in combination with the use of codons which code for tRNAsoccurring as frequently as possible in the cell, the amino acid sequencecoded by the modified RNA preferably not being modified compared to thenon-modified sequence. Alternatively, it is also possible to modify onlythe G/C content or only the codon usage compared to the originalsequence. The source code in Visual Basic 6.0 (development environmentused: Microsoft Visual Studio Enterprise 6.0 with Servicepack 3) is alsodescribed in WO 02/098443. In a further preferred embodiment of thepresent invention, the A/U content in the environment of the ribosomebinding site of the RNA of the present invention is increased comparedto the A/U content in the environment of the ribosome binding site ofits respective wild-type mRNA. This modification (an increased A/Ucontent around the ribosome binding site) increases the efficiency ofribosome binding to the RNA. An effective binding of the ribosomes tothe ribosome binding site (Kozak sequence: SEQ ID NO: 61159 (DNA) or SEQID NO:61160 (RNA), respectively; the AUG forms the start codon) in turnhas the effect of an efficient translation of the RNA. According to afurther embodiment of the present invention, the RNA of the presentinvention may be modified with respect to potentially destabilizingsequence elements. Particularly, the coding region and/or the 5′ and/or3′ untranslated region of this RNA may be modified compared to therespective wild-type RNA such that it contains no destabilizing sequenceelements, the encoded amino acid sequence of the modified RNA preferablynot being modified compared to its respective wild-type RNA. It is knownthat, for example in sequences of eukaryotic RNAs, destabilizingsequence elements (DSE) occur, to which signal proteins bind andregulate enzymatic degradation of RNA in vivo. For further stabilizationof the modified RNA, optionally in the region which encodes an antibodyas defined herein or a fragment or variant thereof, one or more suchmodifications compared to the corresponding region of the wild-type RNAcan therefore be carried out, so that no or substantially nodestabilizing sequence elements are contained there. According to theinvention, DSE present in the untranslated regions (3′- and/or 5′-UTR)can also be eliminated from the RNA of the present invention by suchmodifications. Such destabilizing sequences are e.g. AU-rich sequences(AURES), which occur in 3′-UTR sections of numerous unstable RNAs (Caputet al., Proc. Natl. Acad. Sci. USA 1986, 83: 1670 to 1674). The RNA ofthe present invention is therefore preferably modified compared to therespective wild-type RNA such that the RNA of the present inventioncontains no such destabilizing sequences. This also applies to thosesequence motifs which are recognized by possible endonucleases, e.g. thesequence GAACAAG, which is contained in the 3′-UTR segment of the geneencoding the transferrin receptor (Binder et al., EMBO J. 1994, 13: 1969to 1980). These sequence motifs are also preferably removed in the RNAof the present invention.

GC Optimized Sequences:

In a preferred embodiment, the present invention provides an RNAcomprising at least one coding sequence, wherein the coding sequencecomprises a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 7643-15284, 61162, 61164, 61165, 61167, 61169, 61170, 61172,61174, 61175, 61209-61211, 61215-61217, 61239-61242, 61248-61250,61272-61275, 61282-61284, 61306-61309, 61313, 61321, 61325, 61333,61336, 61339, 61347, 61350, 61358, 61360, 61363, 61371, 61374, 61382,61386, 61387, 61402-61404, 61416, 61419, 61427, 61430, 61438, 61442,61443, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479,61483-61485, 61489-61491, 61495-61497, 61501, 61502, 61517-61519, 61523,61524, 61539-61541, 61545, 61546, 61561-61563, 61566, 61574, 61577,61585, 61589, 61590, 61604, 61607, 61610, 61613, 61615, 61620, 61621,61636, 61637, 61641, 61642, 61646, 61647, 61662-61664, 61668, 61676,61679, 61687, 61690, 61698, 61701, 61709, 61712, 61720, 61723, 61731,and 61733; or a fragment or variant of any one of said nucleic acidsequences.

It is also preferred that the at least one coding sequence of the RNAaccording to the invention comprises or consists of a nucleic acidsequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%,50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%,95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferablyof at least 80%, even more preferably at least 85%, even more preferablyof at least 90% and most preferably of at least 95% or even 97%, with anucleic acid sequence selected from the group consisting of SEQ ID NO:7643-15284, 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174,61175, 61209-61211, 61215-61217, 61239-61242, 61248-61250, 61272-61275,61282-61284, 61306-61309, 61313, 61321, 61325, 61333, 61336, 61339,61347, 61350, 61358, 61360, 61363, 61371, 61374, 61382, 61386, 61387,61402-61404, 61416, 61419, 61427, 61430, 61438, 61442, 61443, 61458,61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491,61495-61497, 61501, 61502, 61517-61519, 61523, 61524, 61539-61541,61545, 61546, 61561-61563, 61566, 61574, 61577, 61585, 61589, 61590,61604, 61607, 61610, 61613, 61615, 61620, 61621, 61636, 61637, 61641,61642, 61646, 61647, 61662-61664, 61668, 61676, 61679, 61687, 61690,61698, 61701, 61709, 61712, 61720, 61723, 61731, and 61733; or afragment or variant of any one of said nucleic acid sequences.

It is also preferred that the RNA comprises at least one codingsequence, wherein the coding sequence comprises a nucleic acid sequenceselected from the group consisting of SEQ ID NO: 38211-45852,61227-1229, 61260-61262, 61294-61296, 61317, 61329, 61343, 61354, 61367,61378, 61394, 61395, 61423, 61434, 61450, 61451, 61509, 61510, 61531,61532, 61553, 61554, 61570, 61581, 61597, 61598, 61628, 61629, 61654,61655, 61672, 61683, 61694, 61705, 61716, and 61727; or a fragment orvariant of any one of said nucleic acid sequences.

Preferably, the at least one coding sequence of the RNA according to theinvention comprises or consists of a nucleic acid sequence having asequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%,80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%,98%, or 99%, preferably of at least 70%, more preferably of at least80%, even more preferably at least 85%, even more preferably of at least90% and most preferably of at least 95% or even 97%, with a nucleic acidsequence selected from the group consisting of SEQ ID NO: 38211-45852,61227-1229, 61260-61262, 61294-61296, 61317, 61329, 61343, 61354, 61367,61378, 61394, 61395, 61423, 61434, 61450, 61451, 61509, 61510, 61531,61532, 61553, 61554, 61570, 61581, 61597, 61598, 61628, 61629, 61654,61655, 61672, 61683, 61694, 61705, 61716, and 61727; or a fragment orvariant of any one of said nucleic acid sequences.

It is also preferred that the RNA comprises at least one codingsequence, wherein the coding sequence comprises a nucleic acid sequenceselected from the group consisting of SEQ ID NO: 45853-53494,61230-61232, 61263-61265, 61297-61299, 61318, 61330, 61344, 61355,61368, 61379, 61396, 61397, 61424, 61435, 61452, 61453, 61511, 61512,61533, 61534, 61555, 61556, 61571, 61582, 61599, 61600, 61630, 61631,61656, 61657, 61673, 61684, 61695, 61706, 61717, 61728; or a fragment orvariant of any one of said nucleic acid sequences.

Preferably, the at least one coding sequence of the RNA according to theinvention comprises or consists of a nucleic acid sequence having asequence identity of at least 5%, 10%, 20%, 30%, ₄₀%, 50%, 60%, 70%,80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%,98%, or 99%, preferably of at least 70%, more preferably of at least80%, even more preferably at least 85%, even more preferably of at least90% and most preferably of at least 95% or even 97%, with a nucleic acidsequence selected from the group consisting of SEQ ID NO: 45853-53494,61230-61232, 61263-61265, 61297-61299, 61318, 61330, 61344, 61355,61368, 61379, 61396, 61397, 61424, 61435, 61452, 61453, 61511, 61512,61533, 61534, 61555, 61556, 61571, 61582, 61599, 61600, 61630, 61631,61656, 61657, 61673, 61684, 61695, 61706, 61717, 61728; or a fragment orvariant of any one of said nucleic acid sequences.

It is also preferred that the RNA comprises at least one codingsequence, wherein the coding sequence comprises a nucleic acid sequenceselected from the group consisting of SEQ ID NOs: 53495-61136,61233-61235, 61266-61268, 61300-61302, 61319, 61331, 61345, 61356,61369, 61380, 61398, 61399, 61425, 61436, 61454, 61455, 61513, 61514,61535, 61536, 61557, 61558, 61572, 61583, 61601, 61602, 61632, 61633,61658, 61659, 61674, 61685, 61696, 61707, 61718, and 61729; or afragment or variant of any one of said nucleic acid sequences.

Preferably, the at least one coding sequence of the RNA according to theinvention comprises or consists of a nucleic acid sequence having asequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%,80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%,98%, or 99%, preferably of at least 70%, more preferably of at least80%, even more preferably at least 85%, even more preferably of at least90% and most preferably of at least 95% or even 97%, with a nucleic acidsequence selected from the group consisting of SEQ ID NOs: 53495-61136,61233-61235, 61266-61268, 61300-61302, 61319, 61331, 61345, 61356,61369, 61380, 61398, 61399, 61425, 61436, 61454, 61455, 61513, 61514,61535, 61536, 61557, 61558, 61572, 61583, 61601, 61602, 61632, 61633,61658, 61659, 61674, 61685, 61696, 61707, 61718, and 61729; or afragment or variant of any one of said nucleic acid sequences.

Sequences Adapted to Human Codon Usage:

According to the invention, a further preferred modification of the RNAof the present invention is based on the finding that codons encodingthe same amino acid typically occur at different frequencies. Accordingto the invention, in the modified RNA of the present invention, thecoding sequence (coding region) as defined herein is preferably modifiedcompared to the corresponding region of the respective wild-type RNAsuch that the frequency of the codons encoding the same amino acidcorresponds to the naturally occurring frequency of that codon accordingto the human codon usage as e.g. shown in Table 10.

For example, in the case of the amino acid alanine (Ala) present in anamino acid sequence encoded by the at least one coding sequence of theRNA according to the invention, the wild type coding sequence ispreferably adapted in a way that the codon “GCC” is used with afrequency of 0.40, the codon “GOT” is used with a frequency of 0.28, thecodon “GCA” is used with a frequency of 0.22 and the codon “GCG” is usedwith a frequency of 0.10 etc. (see Table 10).

TABLE 10 Human codon usage table Aminoacid codon fraction /1000Aminoacid codon fraction /1000 Ala GCG 0.10 7.4 Pro CCG 0.11 6.9 Ala GCA0.22 15.8 Pro CCA 0.27 16.9 Ala GCT 0.28 18.5 Pro CCT 0.29 17.5 Ala GCC*0.40 27.7 Pro CCC* 0.33 19.8 Cys TGT 0.42 10.6 Gln CAG* 0.73 34.2 CysTGC* 0.58 12.6 Gln CAA 0.27 12.3 Asp GAT 0.44 21.8 Arg AGG 0.22 12.0 AspGAC* 0.56 25.1 Arg AGA* 0.21 12.1 Glu GAG* 0.59 39.6 Arg CGG 0.19 11.4Glu GAA 0.41 29.0 Arg CGA 0.10 6.2 Phe TTT 0.43 17.6 Arg CGT 0.09 4.5Phe TTC* 0.57 20.3 Arg CGC 0.19 10.4 Gly GGG 0.23 16.5 Ser AGT 0.14 12.1Gly GGA 0.26 16.5 Ser AGC* 0.25 19.5 Gly GGT 0.18 10.8 Ser TCG 0.06 4.4Gly GGC* 0.33 22.2 Ser TCA 0.15 12.2 His CAT 0.41 10.9 Ser TCT 0.18 15.2His CAC* 0.59 15.1 Ser TCC 0.23 17.7 Ile ATA 0.14 7.5 Thr ACG 0.12 6.1Ile ATT 0.35 16.0 Thr ACA 0.27 15.1 Ile ATC* 0.52 20.8 Thr ACT 0.23 13.1Lys AAG* 0.60 31.9 Thr ACC* 0.38 18.9 Lys AAA 0.40 24.4 Val GTG* 0.4828.1 Leu TTG 0.12 12.9 Val GTA 0.10 7.1 Leu TTA 0.06 7.7 Val GTT 0.1711.0 Leu CTG* 0.43 39.6 Val GTC 0.25 14.5 Leu CTA 0.07 7.2 Trp TGG* 113.2 Leu CTT 0.12 13.2 Tyr TAT 0.42 12.2 Leu CTC 0.20 19.6 Tyr TAC* 0.5815.3 Met ATG* 1 22.0 Stop TGA* 0.61 1.6 Asn AAT 0.44 17.0 Stop TAG 0.170.8 Asn AAC* 0.56 19.1 Stop TM 0.22 1.0 *most frequent codon

In a preferred embodiment, the present invention provides an RNAcomprising at least one coding sequence, wherein the coding sequencecomprises a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 22927-30568, 61221-61223, 61254-61256, 61288-61290, 61315,61327, 61341, 61352, 61365, 61376, 61390, 61391, 61421, 61432, 61446,61447, 61505, 61506, 61527, 61528, 61549, 61550, 61568, 61579, 61593,61594, 61624, 61625, 61650, 61651, 61670, 61681, 61692, 61703, 61714,and 61725; or a fragment or variant of any one of said nucleic acidsequences.

According to a further embodiment, the at least one coding sequence ofthe RNA according to the invention comprises or consists of a nucleicacid sequence having a sequence identity of at least 5%, 10%, 20%, 30%,40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%,94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, morepreferably of at least 80%, even more preferably at least 85%, even morepreferably of at least 90% and most preferably of at least 95% or even97%, with a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 22927-30568, 61221-61223, 61254-61256, 61288-61290, 61315,61327, 61341, 61352, 61365, 61376, 61390, 61391, 61421, 61432, 61446,61447, 61505, 61506, 61527, 61528, 61549, 61550, 61568, 61579, 61593,61594, 61624, 61625, 61650, 61651, 61670, 61681, 61692, 61703, 61714,and 61725; or a fragment or variant of any one of said nucleic acidsequences.

Codon-Optimized Sequences:

As described above it is preferred according to the invention, that allcodons of the wild-type sequence which code for a tRNA, which isrelatively rare in the cell, are exchanged for a codon which codes for atRNA, which is relatively frequent in the cell and which, in each case,carries the same amino acid as the relatively rare tRNA. Therefore it isparticularly preferred that the most frequent codons are used for eachencoded amino acid (see Table 2, most frequent codons are marked withasterisks). Such an optimization procedure increases the codonadaptation index (CAI) and ultimately maximises the CAI. In the contextof the invention, sequences with increased or maximized CAI aretypically referred to as “codon-optimized” sequences and/or CAIincreased and/or maximized sequences. According to a preferredembodiment, the RNA of the present invention comprises at least onecoding sequence, wherein the coding sequence is codon-optimized asdescribed herein. More preferably, the codon adaptation index (CAI) ofthe at least one coding sequence is at least 0.5, at least 0.8, at least0.9 or at least 0.95. Most preferably, the codon adaptation index (CAI)of the at least one coding sequence is 1.

For example, in the case of the amino acid alanine (Ala) present in theamino acid sequence encoded by the at least one coding sequence of theRNA according to the invention, the wild type coding sequence is adaptedin a way that the most frequent human codon “GCC” is always used forsaid amino acid, or for the amino acid Cysteine (Cys), the wild typesequence is adapted in a way that the most frequent human codon “TGC” isalways used for said amino acid etc.

In a preferred embodiment, the present invention provides an RNAcomprising at least one coding sequence, wherein the coding sequencecomprises a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 30569-38210, 61224-61226, 61257-61259, 61291-61293, 61316,61328, 61342, 61353, 61366, 61377, 61392, 61393, 61422, 61433, 61448,61449, 61507, 61508, 61529, 61530, 61551, 61552, 61569, 61580, 61595,61596, 61626, 61627, 61652, 61653, 61671, 61682, 61693, 61704, 61715,and 61726; or a fragment or variant of any one of said nucleic acidsequences.

According to a further embodiment, the at least one coding sequence ofthe RNA according to the invention comprises or consists of a nucleicacid sequence having a sequence identity of at least 5%, 10%, 20%, 30%,40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%,94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, morepreferably of at least 80%, even more preferably at least 85%, even morepreferably of at least 90% and most preferably of at least 95% or even97%, with a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 30569-38210, 61224-61226, 61257-61259, 61291-61293, 61316,61328, 61342, 61353, 61366, 61377, 61392, 61393, 61422, 61433, 61448,61449, 61507, 61508, 61529, 61530, 61551, 61552, 61569, 61580, 61595,61596, 61626, 61627, 61652, 61653, 61671, 61682, 61693, 61704, 61715,and 61726; or a fragment or variant of any one of said nucleic acidsequences.

C-Optimized Sequences:

According to another embodiment, the RNA of the composition of thepresent invention may be modified by modifying, preferably increasing,the cytosine (C) content of the RNA, preferably of the coding region ofthe aRNA.

In a particularly preferred embodiment of the present invention, the Ccontent of the coding region of the RNA of the present invention ismodified, preferably increased, compared to the C content of the codingregion of the respective wild-type RNA, i.e. the unmodified RNA. Theamino acid sequence encoded by the at least one coding sequence of theRNA of the present invention is preferably not modified as compared tothe amino acid sequence encoded by the respective wild-type mRNA.

In a preferred embodiment of the present invention, the modified RNA ismodified such that at least 10%, 20%, 30%, 40%, 50%, 60%, 70% or 80%, orat least 90% of the theoretically possible maximum cytosine-content oreven a maximum cytosine-content is achieved.

In further preferred embodiments, at least 10%, 20%, 30%, 40%, 50%, 60%,70%, 80%, 90% or even 100% of the codons of the target RNA wild typesequence, which are “cytosine content optimizable” are replaced bycodons having a higher cytosine-content than the ones present in thewild type sequence.

In a further preferred embodiment, some of the codons of the wild typecoding sequence may additionally be modified such that a codon for arelatively rare tRNA in the cell is exchanged by a codon for arelatively frequent tRNA in the cell, provided that the substitutedcodon for a relatively frequent tRNA carries the same amino acid as therelatively rare tRNA of the original wild type codon. Preferably, all ofthe codons for a relatively rare tRNA are replaced by a codon for arelatively frequent tRNA in the cell, except codons encoding aminoacids, which are exclusively encoded by codons not containing anycytosine, or except for glutamine (Gln), which is encoded by two codonseach containing the same number of cytosines.

In a further preferred embodiment of the present invention, the modifiedtarget RNA is modified such that at least 80%, or at least 90% of thetheoretically possible maximum cytosine-content or even a maximumcytosine-content is achieved by means of codons, which code forrelatively frequent tRNAs in the cell, wherein the amino acid sequenceremains unchanged.

Due to the naturally occurring degeneracy of the genetic code, more thanone codon may encode a particular amino acid. Accordingly, 18 out of 20naturally occurring amino acids are encoded by more than one codon (withTryp and Met being an exception), e.g. by 2 codons (e.g. Cys, Asp, Glu),by three codons (e.g. Ile), by 4 codons (e.g. Al, Gly, Pro) or by 6codons (e.g. Leu, Arg, Ser). However, not all codons encoding the sameamino acid are utilized with the same frequency under in vivoconditions. Depending on each single organism, a typical codon usageprofile is established.

The term ‘cytosine content-optimizable codon’ as used within the contextof the present invention refers to codons, which exhibit a lower contentof cytosines than other codons encoding the same amino acid.Accordingly, any wild type codon, which may be replaced by another codonencoding the same amino acid and exhibiting a higher number of cytosineswithin that codon, is considered to be cytosine-optimizable(C-optimizable). Any such substitution of a C-optimizable wild typecodon by the specific C-optimized codon within a wild type coding regionincreases its overall C-content and reflects a C-enriched modified mRNAsequence. According to a preferred embodiment, the RNA of the presentinvention, preferably the at least one coding sequence of the RNA of thepresent invention comprises or consists of a C-maximized RNA sequencecontaining C-optimized codons for all potentially C-optimizable codons.Accordingly, 100% or all of the theoretically replaceable C-optimizablecodons are preferably replaced by C-optimized codons over the entirelength of the coding region.

In this context, cytosine-content optimizable codons are codons, whichcontain a lower number of cytosines than other codons coding for thesame amino acid.

Any of the codons GCG, GCA, GCU codes for the amino acid Ala, which maybe exchanged by the codon GCC encoding the same amino acid, and/or

the codon UGU that codes for Cys may be exchanged by the codon UGCencoding the same amino acid, and/or

the codon GAU which codes for Asp may be exchanged by the codon GACencoding the same amino acid, and/or

the codon that UUU that codes for Phe may be exchanged for the codon UUCencoding the same amino acid, and/or

any of the codons GGG, GGA, GGU that code Gly may be exchanged by thecodon GGC encoding the same amino acid, and/or

the codon CAU that codes for His may be exchanged by the codon CACencoding the same amino acid, and/or

any of the codons AUA, AUU that code for Ile may be exchanged by thecodon AUC, and/or

any of the codons UUG, UUA, CUG, CUA, CUU coding for Leu may beexchanged by the codon CUC encoding the same amino acid, and/or

the codon AAU that codes for Asn may be exchanged by the codon AACencoding the same amino acid, and/or

any of the codons CCG, CCA, CCU coding for Pro may be exchanged by thecodon CCC encoding the same amino acid, and/or

any of the codons AGG, AGA, CGG, CGA, CGU coding for Arg may beexchanged by the codon CGC encoding the same amino acid, and/or

any of the codons AGU, AGC, UCG, UCA, UCU coding for Ser may beexchanged by the codon UCC encoding the same amino acid, and/or

any of the codons ACG, ACA, ACU coding for Thr may be exchanged by thecodon ACC encoding the same amino acid, and/or

any of the codons GUG, GUA, GUU coding for Val may be exchanged by thecodon GUC encoding the same amino acid, and/or

the codon UAU coding for Tyr may be exchanged by the codon UAC encodingthe same amino acid.

In any of the above instances, the number of cytosines is increased by 1per exchanged codon. Exchange of all non C-optimized codons(corresponding to C-optimizable codons) of the coding region results ina C-maximized coding sequence. In the context of the invention, at least70%, preferably at least 80%, more preferably at least 90%, of the nonC-optimized codons within the at least one coding region of the RNAaccording to the invention are replaced by C-optimized codons.

It may be preferred that for some amino acids the percentage ofC-optimizable codons replaced by C-optimized codons is less than 70%,while for other amino acids the percentage of replaced codons is higherthan 70% to meet the overall percentage of C-optimization of at least70% of all C-optimizable wild type codons of the coding region.

Preferably, in a C-optimized RNA of the invention, at least 50% of theC-optimizable wild type codons for any given amino acid are replaced byC-optimized codons, e.g. any modified C-enriched RNA preferably containsat least 50% C-optimized codons at C-optimizable wild type codonpositions encoding any one of the above mentioned amino acids Ala, Cys,Asp, Phe, Gly, His, Ile, Leu, Asn, Pro, Arg, Ser, Thr, Val and Tyr,preferably at least 60%.

In this context codons encoding amino acids, which are not cytosinecontent-optimizable and which are, however, encoded by at least twocodons, may be used without any further selection process. However, thecodon of the wild type sequence that codes for a relatively rare tRNA inthe cell, e.g. a human cell, may be exchanged for a codon that codes fora relatively frequent tRNA in the cell, wherein both code for the sameamino acid. Accordingly, the relatively rare codon GAA coding for Glumay be exchanged by the relative frequent codon GAG coding for the sameamino acid, and/or

the relatively rare codon AAA coding for Lys may be exchanged by therelative frequent codon AAG coding for the same amino acid, and/or

the relatively rare codon CAA coding for Gln may be exchanged for therelative frequent codon CAG encoding the same amino acid.

In this context, the amino acids Met (AUG) and Trp (UGG), which areencoded by only one codon each, remain unchanged. Stop codons are notcytosine-content optimized, however, the relatively rare stop codonsamber, ochre (UAA, UAG) may be exchanged by the relatively frequent stopcodon opal (UGA).

The single substitutions listed above may be used individually as wellas in all possible combinations in order to optimize thecytosine-content of the modified RNA compared to the wild type mRNAsequence.

Accordingly, the at least one coding sequence as defined herein may bechanged compared to the coding region of the respective wild type RNA insuch a way that an amino acid encoded by at least two or more codons, ofwhich one comprises one additional cytosine, such a codon may beexchanged by the C-optimized codon comprising one additional cytosine,wherein the amino acid is preferably unaltered compared to the wild typesequence.

In a preferred embodiment, the present invention provides an RNAcomprising at least one coding sequence, wherein the coding sequencecomprises a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 15285-22926, 61218-61220, 61251-61253, 61285-61287, 61314,61326, 61340, 61351, 61364, 61375, 61388, 61389, 61420, 61431, 61444,61445, 61503, 61504, 61525, 61526, 61547, 61548, 61567, 61578, 61591,61592, 61622, 61623, 61648, 61649, 61669, 61680, 61691, 61702, 61713,and 61724; or a fragment or variant of any one of said nucleic acidsequences.

According to a further embodiment, the at least one coding sequence ofthe RNA according to the invention comprises or consists of a nucleicacid sequence having a sequence identity of at least 5%, 10%, 20%, 30%,40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%,94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, morepreferably of at least 80%, even more preferably at least 85%, even morepreferably of at least 90% and most preferably of at least 95% or even97%, with a nucleic acid sequence selected from the group consisting ofSEQ ID NO: 15285-22926, 61218-61220, 61251-61253, 61285-61287, 61314,61326, 61340, 61351, 61364, 61375, 61388, 61389, 61420, 61431, 61444,61445, 61503, 61504, 61525, 61526, 61547, 61548, 61567, 61578, 61591,61592, 61622, 61623, 61648, 61649, 61669, 61680, 61691, 61702, 61713,and 61724; or a fragment or variant of any one of said nucleic acidsequences.

According to a particularly preferred embodiment, the invention providesan RNA, preferably an mRNA, comprising at least one coding sequence asdefined herein, wherein the G/C content of the at least one codingsequence of the RNA is increased compared to the G/C content of thecorresponding coding sequence of the corresponding wild-type RNA, and/or

wherein the C content of the at least one coding sequence of the RNA isincreased compared to the C content of the corresponding coding sequenceof the corresponding wild-type RNA, and/or wherein the codons in the atleast one coding sequence of the RNA are adapted to human codon usage,wherein the codon adaptation index (CAI) is preferably increased ormaximised in the at least one coding sequence of the RNA,

and wherein the amino acid sequence encoded by the RNA is preferably notbeing modified compared to the amino acid sequence encoded by thecorresponding wild-type RNA.

Accordingly, the nucleic acid sequence, which is comprised by the atleast one coding sequence of the inventive RNA, is preferably selectedfrom the group consisting of SEQ ID NO: 7643-61136, 61162, 61164, 61165,61167, 61169, 61170, 61172, 61174, 61175, 61209-61211, 61215-61235,61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347,61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382,61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438,61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479,61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519,61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615,61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664,61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707,61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244,61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337,61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410,61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485,61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586,61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612,61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677,61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment orvariant of any one of said nucleic acid sequences.

It is also preferred that the at least one coding sequence of the RNAaccording to the invention comprises or consists of a nucleic acidsequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%,50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%,95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferablyof at least 80%, even more preferably at least 85%, even more preferablyof at least 90% and most preferably of at least 95% or even 97%, with anucleic acid sequence selected from the group consisting of SEQ ID NO:7643-61136, 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174,61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275,61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336,61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371,61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427,61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467,61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497,61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558,61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604,61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642,61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687,61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729,61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322,61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404,61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428,61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473,61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520,61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608,61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733,and 61734; or a fragment or variant of any one of said nucleic acidsequences.

According to another preferred embodiment of the invention, a modifiedRNA as defined herein, can be modified by the addition of a so-called‘5’ cap' structure, which preferably stabilizes the RNA as describedherein. A 5′-cap is an entity, typically a modified nucleotide entity,which generally “caps” the 5′-end of a mature mRNA. A 5′-cap maytypically be formed by a modified nucleotide, particularly by aderivative of a guanine nucleotide. Preferably, the 5′-cap is linked tothe 5′-terminus via a 5′-5′-triphosphate linkage. A 5′-cap may bemethylated, e.g. m7GpppN, wherein N is the terminal 5′ nucleotide of thenucleic acid carrying the 5′-cap, typically the 5′-end of an mRNA.m7GpppN is the 5′-cap structure, which naturally occurs in mRNAtranscribed by polymerase II and is therefore preferably not consideredas modification comprised in a modified mRNA in this context.Accordingly, a modified RNA of the present invention may comprise am7GpppN as 5′-cap, but additionally the modified RNA typically comprisesat least one further modification as defined herein.

Further examples of 5′cap structures include glyceryl, inverted deoxyabasic residue (moiety), 4′,5′ methylene nucleotide,1-(beta-D-erythrofuranosyl) nucleotide, 4′-thio nucleotide, carbocyclicnucleotide, 1,5-anhydrohexitol nucleotide, L-nucleotides,alpha-nucleotide, modified base nucleotide, threo-pentofuranosylnucleotide, acyclic 3′,4′-seco nucleotide, acyclic 3,4-dihydroxybutylnucleotide, acyclic 3,5 dihydroxypentyl nucleotide, 3′-3′-invertednucleotide moiety, 3′-3′-inverted abasic moiety, 3′-2′-invertednucleotide moiety, 3′-2′-inverted abasic moiety, 1,4-butanediolphosphate, 3′-phosphoramidate, hexylphosphate, aminohexyl phosphate,3′-phosphate, 3′phosphorothioate, phosphorodithioate, or bridging ornon-bridging methylphosphonate moiety. These modified 5′-cap structuresare regarded as at least one modification in this context.

Particularly preferred modified 5′-cap structures are cap1 (methylationof the ribose of the adjacent nucleotide of m7G), cap2 (additionalmethylation of the ribose of the 2nd nucleotide downstream of the m7G),cap3 (additional methylation of the ribose of the 3rd nucleotidedownstream of the m7G), cap4 (methylation of the ribose of the 4thnucleotide downstream of the m7G), ARCA (anti-reverse cap analogue,modified ARCA (e.g. phosphothioate modified ARCA), inosine,N1-methyl-guanosine, 2′-fluoro-guanosine, 7-deaza-guanosine,8-oxo-guanosine, 2-amino-guanosine, LNA-guanosine, and2-azido-guanosine. Accordingly, the RNA according to the inventionpreferably comprises a 5′-cap structure.

In a preferred embodiment, the RNA according to the invention comprisesat least one 5′- or 3′-UTR element. In this context, an UTR elementcomprises or consists of a nucleic acid sequence, which is derived fromthe 5′- or 3′-UTR of any naturally occurring gene or which is derivedfrom a fragment, a homolog or a variant of the 5′- or 3′-UTR of a gene.Preferably, the 5′- or 3′-UTR element used according to the presentinvention is heterologous to the at least one coding sequence of the RNAof the invention. Even if 5′- or 3′-UTR elements derived from naturallyoccurring genes are preferred, also synthetically engineered UTRelements may be used in the context of the present invention.

The term ‘3′UTR element’ typically refers to a nucleic acid sequence,which comprises or consists of a nucleic acid sequence that is derivedfrom a 3′UTR or from a variant of a 3′UTR. A 3′UTR element in the senseof the present invention may represent the 3′UTR of an RNA, preferablyan mRNA. Thus, in the sense of the present invention, preferably, a3′UTR element may be the 3′UTR of an RNA, preferably of an mRNA, or itmay be the transcription template for a 3′UTR of an RNA. Thus, a 3′UTRelement preferably is a nucleic acid sequence which corresponds to the3′UTR of an RNA, preferably to the 3′UTR of an mRNA, such as an mRNAobtained by transcription of a genetically engineered vector construct.Preferably, the 3′UTR element fulfils the function of a 3′UTR or encodesa sequence which fulfils the function of a 3′UTR.

According to a preferred embodiment, the RNA, preferably an mRNA,according to the invention comprises a 5′-cap structure and/or at leastone 3′-untranslated region element (3′-UTR element), preferably asdefined herein. More preferably, the RNA further comprises a 5′-UTRelement as defined herein.

According to a further preferred embodiment, the RNA of the presentinvention may contain a poly-A tail on the 3′ terminus of typicallyabout 10 to 200 adenosine nucleotides, preferably about 10 to 100adenosine nucleotides, more preferably about 40 to 80 adenosinenucleotides or even more preferably about 50 to 70 adenosinenucleotides.

Preferably, the poly(A) sequence in the RNA of the present invention isderived from a DNA template by RNA in vitro transcription.Alternatively, the poly(A) sequence may also be obtained in vitro bycommon methods of chemical-synthesis without being necessarilytranscribed from a DNA-progenitor. Moreover, poly(A) sequences, orpoly(A) tails may be generated by enzymatic polyadenylation of the RNAaccording to the present invention using commercially availablepolyadenylation kits and corresponding protocols known in the art.

Alternatively, the RNA as described herein optionally comprises apolyadenylation signal, which is defined herein as a signal, whichconveys polyadenylation to a (transcribed) RNA by specific proteinfactors (e.g. cleavage and polyadenylation specificity factor (CPSF),cleavage stimulation factor (CstF), cleavage factors I and II (CF I andCF II), poly(A) polymerase (PAP)). In this context, a consensuspolyadenylation signal is preferred comprising the NN(U/T)ANA consensussequence. In a particularly preferred aspect, the polyadenylation signalcomprises one of the following sequences: AA(U/T)AAA or A(U/T)(U/T)AAA(wherein uridine is usually present in RNA and thymidine is usuallypresent in DNA).

According to a further preferred embodiment, the RNA of the presentinvention may contain a poly(C) tail on the 3′ terminus of typicallyabout 10 to 200 cytosine nucleotides, preferably about 10 to 100cytosine nucleotides, more preferably about 20 to 70 cytosinenucleotides or even more preferably about 20 to 60 or even 10 to 40cytosine nucleotides.

In a further preferred embodiment, the RNA according to the inventionfurther comprises at least one 3′UTR element. Preferably, the at leastone 3′UTR element comprises or consists of a nucleic acid sequencederived from the 3′UTR of a chordate gene, preferably a vertebrate gene,more preferably a mammalian gene, most preferably a human gene, or froma variant of the 3′UTR of a chordate gene, preferably a vertebrate gene,more preferably a mammalian gene, most preferably a human gene.

Preferably, the RNA of the present invention comprises a 3′UTR element,which may be derivable from a gene that relates to an mRNA with anenhanced half-life (that provides a stable mRNA), for example a 3′UTRelement as defined and described below. Preferably, the 3′-UTR elementis a nucleic acid sequence derived from a 3′-UTR of a gene, whichpreferably encodes a stable mRNA, or from a homolog, a fragment or avariant of said gene

In a particularly preferred embodiment, the 3′UTR element comprises orconsists of a nucleic acid sequence, which is derived from a 3′UTR of agene selected from the group consisting of an albumin gene, an α-globingene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene,and a collagen alpha gene, such as a collagen alpha 1(1) gene, or from avariant of a 3′UTR of a gene selected from the group consisting of analbumin gene, an α-globin gene, a β-globin gene, a tyrosine hydroxylasegene, a lipoxygenase gene, and a collagen alpha gene, such as a collagenalpha 1(I) gene according to SEQ ID NOs: 1369-1390 of the patentapplication WO2013/143700, whose disclosure is incorporated herein byreference, or from a homolog, a fragment or a variant thereof. In aparticularly preferred embodiment, the 3′UTR element comprises orconsists of a nucleic acid sequence which is derived from a 3′UTR of analbumin gene, preferably a vertebrate albumin gene, more preferably amammalian albumin gene, most preferably a human albumin gene accordingto SEQ ID NO: 61151 or the corresponding RNA sequence SEQ ID NO: 61152.

In this context it is particularly preferred that the RNA according tothe invention comprises a 3′-UTR element comprising a corresponding RNAsequence derived from the nucleic acids according to SEQ ID NOs:1369-1390 of the patent application WO2013/143700 or a fragment, homologor variant thereof.

Most preferably the 3′-UTR element comprises the nucleic acid sequencederived from a fragment of the human albumin gene according to SEQ IDNOs: 61153 or 61155.

In this context, it is particularly preferred that the 3′-UTR element ofthe RNA according to the present invention comprises or consists of acorresponding RNA sequence of the nucleic acid sequence according to SEQID NO: 61153 or 61155 as shown in SEQ ID NOs: 61154 or 61156.

In another particularly preferred embodiment, the 3′UTR elementcomprises or consists of a nucleic acid sequence which is derived from a3′UTR of an α-globin gene, preferably a vertebrate α- or β-globin gene,more preferably a mammalian α- or β-globin gene, most preferably a humanα- or β-globin gene according to SEQ ID NOs: 61143, 61145 or 61147 orthe corresponding RNA sequences SEQ ID NOs: 61144, 61146 or 61148.

For example, the 3′UTR element may comprise or consist of the center,α-complex-binding portion of the 3′UTR of an α-globin gene, such as of ahuman α-globin gene, or a homolog, a fragment, or a variant of anα-globin gene, preferably according to SEQ ID NO: 61149:

Center, α-complex-binding portion of the 3′UTR of an α-globin gene (alsonamed herein as “muag”) GCCCGATGGGCCTCCCAACGGGCCCTCCTCCCCTCCTTGCACCG(SEQ ID NO: 61149 corresponding to SEQ ID NO: 1393 of the patentapplication WO2013/143700).

In this context it is particularly preferred that the 3′-UTR element ofthe RNA according to the invention comprises or consists of acorresponding RNA sequence of the nucleic acid sequence according to SEQID NO: 61149 as shown in SEQ ID NO: 61150, or a homolog, a fragment orvariant thereof.

The term ‘a nucleic acid sequence which is derived from the 3′UTR of a [. . . ] gene’ preferably refers to a nucleic acid sequence which isbased on the 3′UTR sequence of a [ . . . ] gene or on a part thereof,such as on the 3′UTR of an albumin gene, an α-globin gene, a β-globingene, a tyrosine hydroxylase gene, a lipoxygenase gene, or a collagenalpha gene, such as a collagen alpha 1(I) gene, preferably of an albumingene or on a part thereof. This term includes sequences corresponding tothe entire 3′UTR sequence, i.e. the full length 3′UTR sequence of agene, and sequences corresponding to a fragment of the 3′UTR sequence ofa gene, such as an albumin gene, α-globin gene, β-globin gene, tyrosinehydroxylase gene, lipoxygenase gene, or collagen alpha gene, such as acollagen alpha 1(I) gene, preferably of an albumin gene.

The term ‘a nucleic acid sequence which is derived from a variant of the3′UTR of a [ . . . ] gene’ preferably refers to a nucleic acid sequence,which is based on a variant of the 3′UTR sequence of a gene, such as ona variant of the 3′UTR of an albumin gene, an α-globin gene, a β-globingene, a tyrosine hydroxylase gene, a lipoxygenase gene, or a collagenalpha gene, such as a collagen alpha 1(I) gene, or on a part thereof asdescribed above. This term includes sequences corresponding to theentire sequence of the variant of the 3′UTR of a gene, i.e. the fulllength variant 3′UTR sequence of a gene, and sequences corresponding toa fragment of the variant 3′UTR sequence of a gene. A fragment in thiscontext preferably consists of a continuous stretch of nucleotidescorresponding to a continuous stretch of nucleotides in the full-lengthvariant 3′UTR, which represents at least 20%, preferably at least 30%,more preferably at least 40%, more preferably at least 50%, even morepreferably at least 60%, even more preferably at least 70%, even morepreferably at least 80%, and most preferably at least 90% of thefull-length variant 3′UTR. Such a fragment of a variant, in the sense ofthe present invention, is preferably a functional fragment of a variantas described herein.

In a particularly preferred embodiment, the at least one mRNA of theinventive composition comprises at least one 5′-untranslated regionelement (5′UTR element). Preferably, the at least one 5′UTR elementcomprises or consists of a nucleic acid sequence, which is derived fromthe 5′UTR of a TOP gene or which is derived from a fragment, homolog orvariant of the 5′UTR of a TOP gene.

It is particularly preferred that the 5′UTR element does not comprise aTOP-motif or a 5′TOP, as defined above.

In some embodiments, the nucleic acid sequence of the 5′UTR element,which is derived from a 5′UTR of a TOP gene, terminates at its 3′-endwith a nucleotide located at position 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10upstream of the start codon (e.g. A(U/T)G) of the gene or mRNA it isderived from. Thus, the 5′UTR element does not comprise any part of theprotein coding region. Thus, preferably, the only protein coding part ofthe at least one mRNA of the inventive composition is provided by thecoding region.

The nucleic acid sequence derived from the 5′UTR of a TOP gene ispreferably derived from a eukaryotic TOP gene, preferably a plant oranimal TOP gene, more preferably a chordate TOP gene, even morepreferably a vertebrate TOP gene, most preferably a mammalian TOP gene,such as a human TOP gene.

For example, the 5′UTR element is preferably selected from 5′-UTRelements comprising or consisting of a nucleic acid sequence, which isderived from a nucleic acid sequence selected from the group consistingof SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO:1422 of the patent application WO2013/143700, whose disclosure isincorporated herein by reference, from the homologs of SEQ ID NOs:1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of thepatent application WO2013/143700, from a variant thereof, or preferablyfrom a corresponding RNA sequence. The term “homologs of SEQ ID NOs:1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of thepatent application WO2013/143700” refers to sequences of other speciesthan Homo sapiens, which are homologous to the sequences according toSEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422of the patent application WO2013/143700.

In a preferred embodiment, the 5′UTR element of the RNA according to theinvention comprises or consists of a nucleic acid sequence, which isderived from a nucleic acid sequence extending from nucleotide position5 (i.e. the nucleotide that is located at position 5 in the sequence) tothe nucleotide position immediately 5′ to the start codon (located atthe 3′ end of the sequences), e.g. the nucleotide position immediately5′ to the ATG sequence, of a nucleic acid sequence selected from SEQ IDNOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of thepatent application WO2013/143700, from the homologs of SEQ IDNOs:1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of thepatent application WO2013/143700 from a variant thereof, or acorresponding RNA sequence. It is particularly preferred that the 5′ UTRelement is derived from a nucleic acid sequence extending from thenucleotide position immediately 3′ to the 5′TOP to the nucleotideposition immediately 5′ to the start codon (located at the 3′ end of thesequences), e.g. the nucleotide position immediately 5′ to the ATGsequence, of a nucleic acid sequence selected from SEQ ID NOs:1-1363,SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patentapplication WO2013/143700, from the homologs of SEQ ID NOs:1-1363, SEQID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patentapplication WO2013/143700, from a variant thereof, or a correspondingRNA sequence.

In a particularly preferred embodiment, the 5′UTR element comprises orconsists of a nucleic acid sequence, which is derived from a 5′UTR of aTOP gene encoding a ribosomal protein or from a variant of a 5′UTR of aTOP gene encoding a ribosomal protein. For example, the 5′UTR elementcomprises or consists of a nucleic acid sequence, which is derived froma 5′UTR of a nucleic acid sequence according to any of SEQ ID NOs: 67,170, 193, 244, 259, 554, 650, 675, 700, 721, 913, 1016, 1063, 1120,1138, and 1284-1360 of the patent application WO2013/143700, acorresponding RNA sequence, a homolog thereof, or a variant thereof asdescribed herein, preferably lacking the 5′TOP motif. As describedabove, the sequence extending from position 5 to the nucleotideimmediately 5′ to the ATG (which is located at the 3′end of thesequences) corresponds to the 5′UTR of said sequences.

Preferably, the 5′UTR element comprises or consists of a nucleic acidsequence, which is derived from a 5′UTR of a TOP gene encoding aribosomal Large protein (RPL) or from a homolog or variant of a 5′UTR ofa TOP gene encoding a ribosomal Large protein (RPL). For example, the5′UTR element comprises or consists of a nucleic acid sequence, which isderived from a 5′UTR of a nucleic acid sequence according to any of SEQID NOs: 67, 259, 1284-1318, 1344, 1346, 1348-1354, 1357, 1358, 1421 and1422of the patent application WO2013/143700, a corresponding RNAsequence, a homolog thereof, or a variant thereof as described herein,preferably lacking the 5′TOP motif.

In a particularly preferred embodiment, the 5′UTR element comprises orconsists of a nucleic acid sequence which is derived from the 5′UTR of aribosomal protein Large 32 gene, preferably from a vertebrate ribosomalprotein Large 32 (L32) gene, more preferably from a mammalian ribosomalprotein Large 32 (L32) gene, most preferably from a human ribosomalprotein Large 32 (L32) gene, or from a variant of the 5′UTR of aribosomal protein Large 32 gene, preferably from a vertebrate ribosomalprotein Large 32 (L32) gene, more preferably from a mammalian ribosomalprotein Large 32 (L32) gene, most preferably from a human ribosomalprotein Large 32 (L32) gene, wherein preferably the 5′UTR element doesnot comprise the 5′TOP of said gene.

Accordingly, in a particularly preferred embodiment, the 5′UTR elementcomprises or consists of a nucleic acid sequence, which has an identityof at least about 40%, preferably of at least about 50%, preferably ofat least about 60%, preferably of at least about 70%, more preferably ofat least about 80%, more preferably of at least about 90%, even morepreferably of at least about 95%, even more preferably of at least about99% to the nucleic acid sequence according to SEQ ID NO: 61137 (5′-UTRof human ribosomal protein Large 32 lacking the 5′ terminaloligopyrimidine tract: GGCGCTGCCTACGGAGGTGGCAGCCATCTCCTTCTCGGCATC;corresponding to SEQ ID NO: 1368 of the patent applicationWO2013/143700) or preferably to a corresponding RNA sequence (such asSEQ ID NO: 61138), or wherein the at least one 5′UTR element comprisesor consists of a fragment of a nucleic acid sequence which has anidentity of at least about 40%, preferably of at least about 50%,preferably of at least about 60%, preferably of at least about 70%, morepreferably of at least about 80%, more preferably of at least about 90%,even more preferably of at least about 95%, even more preferably of atleast about 99% to the nucleic acid sequence according to SEQ ID NO:61137 or more preferably to a corresponding RNA sequence (SEQ ID NO:61138), wherein, preferably, the fragment is as described above, i.e.being a continuous stretch of nucleotides representing at least 20% etc.of the full-length 5′UTR. Preferably, the fragment exhibits a length ofat least about 20 nucleotides or more, preferably of at least about 30nucleotides or more, more preferably of at least about 40 nucleotides ormore. Preferably, the fragment is a functional fragment as describedherein.

In some embodiments, the RNA according to the invention comprises a5′UTR element, which comprises or consists of a nucleic acid sequence,which is derived from the 5′UTR of a vertebrate TOP gene, such as amammalian, e.g. a human TOP gene, selected from RPSA, RPS2, RPS3, RPS3A,RPS4, RPS5, RPS6, RPS7, RPS8, RPS9, RPS10, RPS11, RPS12, RPS13, RPS14,RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24,RPS25, RPS26, RPS27, RPS27A, RPS28, RPS29, RPS30, RPL3, RPL4, RPL5,RPL6, RPL7, RPL7A, RPL8, RPL9, RPL10, RPL10A, RPL11, RPL12, RPL13,RPL13A, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23,RPL23A, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL30, RPL31, RPL32,RPL34, RPL35, RPL35A, RPL36, RPL36A, RPL37, RPL37A, RPL38, RPL39, RPL40,RPL41, RPLP0, RPLP1, RPLP2, RPLP3, RPLP0, RPLP1, RPLP2, EEF1A1, EEF1B2,EEF1D, EEF1G, EEF2, EIF3E, EIF3F, EIF3H, EIF2S3, EIF3C, EIF3K, EIF3EIP,EIF4A2, PABPC1, HNRNPA1, TPT1, TUBB1, UBA52, NPM1, ATP5G2, GNB2L1, NME2,UQCRB, or from a homolog or variant thereof, wherein preferably the5′UTR element does not comprise a TOP-motif or the 5′TOP of said genes,and wherein optionally the 5′UTR element starts at its 5′-end with anucleotide located at position 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10downstream of the 5′terminal oligopyrimidine tract (TOP) and whereinfurther optionally the 5′UTR element which is derived from a 5′UTR of aTOP gene terminates at its 3′-end with a nucleotide located at position1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 upstream of the start codon (A(U/T)G) ofthe gene it is derived from.

In further particularly preferred embodiments, the 5′UTR elementcomprises or consists of a nucleic acid sequence, which is derived fromthe 5′UTR of a ribosomal protein Large 32 gene (RPL32), a ribosomalprotein Large 35 gene (RPL35), a ribosomal protein Large 21 gene(RPL21), an ATP synthase, H+ transporting, mitochondrial F1 complex,alpha subunit 1, cardiac muscle (ATP5A1) gene, an hydroxysteroid(17-beta) dehydrogenase 4 gene (HSD17B4), an androgen-induced 1 gene(AIG1), cytochrome c oxidase subunit Vic gene (COX6C), or aN-acylsphingosine amidohydrolase (acid ceramidase) 1 gene (ASAH1) orfrom a variant thereof, preferably from a vertebrate ribosomal proteinLarge 32 gene (RPL32), a vertebrate ribosomal protein Large 35 gene(RPL35), a vertebrate ribosomal protein Large 21 gene (RPL21), avertebrate ATP synthase, H+ transporting, mitochondrial F1 complex,alpha subunit 1, cardiac muscle (ATP5A1) gene, a vertebratehydroxysteroid (17-beta) dehydrogenase 4 gene (HSD17B4), a vertebrateandrogen-induced 1 gene (AIG1), a vertebrate cytochrome c oxidasesubunit Vic gene (COX6C), or a vertebrate N-acylsphingosineamidohydrolase (acid ceramidase) 1 gene (ASAH1) or from a variantthereof, more preferably from a mammalian ribosomal protein Large 32gene (RPL32), a ribosomal protein Large 35 gene (RPL35), a ribosomalprotein Large 21 gene (RPL21), a mammalian ATP synthase, H+transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle(ATP5A1) gene, a mammalian hydroxysteroid (17-beta) dehydrogenase 4 gene(HSD17B4), a mammalian androgen-induced 1 gene (AIG1), a mammaliancyto-chrome c oxidase subunit Vic gene (COX6C), or a mammalianN-acylsphingosine ami-dohydrolase (acid ceramidase) 1 gene (ASAH1) orfrom a variant thereof, most preferably from a human ribosomal proteinLarge 32 gene (RPL32), a human ribosomal protein Large 35 gene (RPL35),a human ribosomal protein Large 21 gene (RPL21), a human ATP syn-thase,H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiacmuscle (ATP5A1) gene, a human hydroxysteroid (17-beta) dehydrogenase 4gene (HSD17B4), a human androgen-induced 1 gene (AIG1), a humancytochrome c oxidase subunit VIc gene (COX6C), or a humanN-acylsphingosine amidohydrolase (acid ceramidase) 1 gene (ASAH1) orfrom a variant thereof, wherein preferably the 5′UTR element does notcomprise the 5′TOP of said gene.

Accordingly, in a particularly preferred embodiment, the 5′UTR elementcomprises or consists of a nucleic acid sequence, which has an identityof at least about 40%, preferably of at least about 50%, preferably ofat least about 60%, preferably of at least about 70%, more preferably ofat least about 80%, more preferably of at least about 90%, even morepreferably of at least about 95%, even more preferably of at least about99% to the nucleic acid sequence according to SEQ ID NO: 1368, or SEQ IDNOs: 1412-1420 of the patent application WO2013/143700, or acorresponding RNA sequence, or wherein the at least one 5′UTR elementcomprises or consists of a fragment of a nucleic acid sequence which hasan identity of at least about 40%, preferably of at least about 50%,preferably of at least about 60%, preferably of at least about 70%, morepreferably of at least about 80%, more preferably of at least about 90%,even more preferably of at least about 95%, even more preferably of atleast about 99% to the nucleic acid sequence according to SEQ ID NO:1368, or SEQ ID NOs: 1412-1420 of the patent application WO2013/143700,wherein, preferably, the fragment is as described above, i.e. being acontinuous stretch of nucleotides representing at least 20% etc. of thefull-length 5′UTR. Preferably, the fragment exhibits a length of atleast about 20 nucleotides or more, preferably of at least about 30nucleotides or more, more preferably of at least about 40 nucleotides ormore. Preferably, the fragment is a functional fragment as describedherein.

Accordingly, in a particularly preferred embodiment, the 5′UTR elementcomprises or consists of a nucleic acid sequence, which has an identityof at least about 40%, preferably of at least about 50%, preferably ofat least about 60%, preferably of at least about 70%, more preferably ofat least about 80%, more preferably of at least about 90%, even morepreferably of at least about 95%, even more preferably of at least about99% to the nucleic acid sequence according to SEQ ID NO: 61139 or 61140(5′-UTR of ATP5A1 lacking the 5′ terminal oligopyrimidine tract:GCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAG; corresponding to SEQ ID NO: 1414 of the patentapplication WO2013/143700) or preferably to a corresponding RNAsequence, or wherein the at least one 5′UTR element comprises orconsists of a fragment of a nucleic acid sequence which has an identityof at least about 40%, preferably of at least about 50%, preferably ofat least about 60%, preferably of at least about 70%, more preferably ofat least about 80%, more preferably of at least about 90%, even morepreferably of at least about 95%, even more preferably of at least about99% to the nucleic acid sequence according to SEQ ID NO: 61139or morepreferably to a corresponding RNA sequence (SEQ ID NO: 61140), wherein,preferably, the fragment is as described above, i.e. being a continuousstretch of nucleotides representing at least 20% etc. of the full-length5′UTR. Preferably, the fragment exhibits a length of at least about 20nucleotides or more, preferably of at least about 30 nucleotides ormore, more preferably of at least about 40 nucleotides or more.Preferably, the fragment is a functional fragment as described herein.

As described above, the 5′UTR element preferably comprises or consistsof a nucleic acid sequence, which is derived from the 5′UTR of ahydroxysteroid (17-beta) dehydrogenase 4 gene (gene HSD17B4, whichencodes peroxisomal multifunctional enzyme type 2, first identified as17-beta-estradiol dehydrogenase). More preferably, such a 5′UTR elementlacks the 5′ terminal oligopyrimidine tract.

Accordingly, in a particularly preferred embodiment, the 5′UTR elementcomprises or consists of a nucleic acid sequence, which has an identityof at least about 40%, preferably of at least about 50%, preferably ofat least about 60%, preferably of at least about 70%, more preferably ofat least about 80%, more preferably of at least about 90%, even morepreferably of at least about 95%, even more preferably of at least about99% to the nucleic acid sequence according to SEQ ID NO: 61141 (5′-UTRof HSD17B4 lacking the 5′ terminal oligopyrimidine tract) or preferablyto a corresponding RNA sequence (such as SEQ ID NO: 61142), or whereinthe at least one 5′UTR element comprises or consists of a fragment of anucleic acid sequence which has an identity of at least about 40%,preferably of at least about 50%, preferably of at least about 60%,preferably of at least about 70%, more preferably of at least about 80%,more preferably of at least about 90%, even more preferably of at leastabout 95%, even more preferably of at least about 99% to the nucleicacid sequence according to SEQ ID NO: 61141 or more preferably to acorresponding RNA sequence (SEQ ID NO: 61142), wherein, preferably, thefragment is as described above, i.e. being a continuous stretch ofnucleotides representing at least 20% etc. of the full-length 5′UTR.Preferably, the fragment exhibits a length of at least about 20nucleotides or more, preferably of at least about 30 nucleotides ormore, more preferably of at least about 40 nucleotides or more.Preferably, the fragment is a functional fragment as described herein.

Preferably, the at least one 5′UTR element and the at least one 3′UTRelement act synergistically to increase protein production from the atleast one mRNA of the inventive composition as described above.

In a particularly preferred embodiment, the RNA according to theinvention comprises a histone stem-loop sequence/structure. Such histonestem-loop sequences are preferably selected from histone stem-loopsequences as disclosed in WO 2012/019780, the disclosure of which isincorporated herewith by reference.

-   A histone stem-loop sequence, suitable to be used within the present    invention, is preferably selected from at least one of the following    formulae (I) or (II):

wherein:

-   stem1 or stem2 bordering elements N₁₋₆ is a consecutive sequence of    1 to 6, preferably of 2 to 6, more preferably of 2 to 5, even more    preferably of 3 to 5, most preferably of 4 to 5 or 5 N, wherein each    N is independently from another selected from a nucleotide selected    from A, U, T, G and C, or a nucleotide analogue thereof;-   stem1 [N₀₋₂GN₃₋₅] is reverse complementary or partially reverse    complementary with element stem2, and is a consecutive sequence    between of 5 to 7 nucleotides;    -   wherein N₀₋₂ is a consecutive sequence of 0 to 2, preferably of        0 to 1, more preferably of 1 N, wherein each N is independently        from another selected from a nucleotide selected from A, U, T, G        and C or a nucleotide analogue thereof;    -   wherein N₃₋₅ is a consecutive sequence of 3 to 5, preferably of        4 to 5, more preferably of 4 N, wherein each N is independently        from another selected from a nucleotide selected from A, U, T, G        and C or a nucleotide analogue thereof, and    -   wherein G is guanosine or an analogue thereof, and may be        optionally replaced by a cytidine or an analogue thereof,        provided that its complementary nucleotide cytidine in stem2 is        replaced by guanosine;-   loop sequence [N₀₋₄(U/T)N₀₋₄] is located between elements stem1 and    stem2, and is a consecutive sequence of 3 to 5 nucleotides, more    preferably of 4 nucleotides;    -   wherein each N₀₋₄ is independent from another a consecutive        sequence of 0 to 4, preferably of 1 to 3, more preferably of 1        to 2 N, wherein each N is independently from another selected        from a nucleotide selected from A, U, T, G and C or a nucleotide        analogue thereof; and    -   wherein U/T represents uridine, or optionally thymidine;-   stem2 [N₃₋₅CN₀₋₂] is reverse complementary or partially reverse    complementary with element stem1, and is a consecutive sequence    between of 5 to 7 nucleotides;    -   wherein N₃₋₅ is a consecutive sequence of 3 to 5, preferably of        4 to 5, more preferably of 4 N, wherein each N is independently        from another selected from a nucleotide selected from A, U, T, G        and C or a nucleotide analogue thereof;    -   wherein N₀₋₂ is a consecutive sequence of 0 to 2, preferably of        0 to 1, more preferably of 1 N, wherein each N is independently        from another selected from a nucleotide selected from A, U, T, G        or C or a nucleotide analogue thereof; and    -   wherein C is cytidine or an analogue thereof, and may be        optionally replaced by a guanosine or an analogue thereof        provided that its complementary nucleoside guanosine in stem1 is        replaced by cytidine;

wherein

stem1 and stem2 are capable of base pairing with each other forming areverse complementary sequence, wherein base pairing may occur betweenstem1 and stem2, e.g. by Watson-Crick base pairing of nucleotides A andU/T or G and C or by non-Watson-Crick base pairing e.g. wobble basepairing, reverse Watson-Crick base pairing, Hoogsteen base pairing,reverse Hoogsteen base pairing or are capable of base pairing with eachother forming a partially reverse complementary sequence, wherein anincomplete base pairing may occur between stem1 and stem2, on the basisthat one ore more bases in one stem do not have a complementary base inthe reverse complementary sequence of the other stem.

-   According to a further preferred embodiment, the RNA according to    the invention may comprise at least one histone stem-loop sequence    according to at least one of the following specific formulae (Ia) or    (IIa):

wherein:

N, C, G, T and U are as defined above.

-   According to a further more particularly preferred embodiment, the    RNA according to the invention may comprise at least one histone    stem-loop sequence according to at least one of the following    specific formulae (Ib) or (IIb):

wherein:

N, C, G, T and U are as defined above.

A particular preferred histone stem-loop sequence is the sequenceCAAAGGCTCTTTTCAGAGCCACCA (according to SEQ ID NO: 61157) or morepreferably the corresponding RNA sequence CAAAGGCUCUUUUCAGAGCCACCA(according to SEQ ID NO: 61158).

According to another particularly preferred embodiment, the RNAaccording to the invention may additionally or alternatively encode asecretory signal peptide. Such signal peptides are sequences, whichtypically exhibit a length of about 15 to 30 amino acids and arepreferably located at the N-terminus of the encoded peptide, withoutbeing limited thereto. Signal peptides as defined herein preferablyallow the transport of the antibody or the fragment thereof as encodedby the at least one mRNA of the composition into a defined cellularcompartiment, preferably the cell surface, the endoplasmic reticulum(ER) or the endosomal-lysosomal compartiment. Examples of secretorysignal peptide sequences as defined herein include, without beinglimited thereto, signal sequences of classical or non-classicalMHC-molecules (e.g. signal sequences of MHC I and II molecules, e.g. ofthe MHC class I molecule HLA-A*0201), signal sequences of cytokines orimmunoglobulines as defined herein, signal sequences of the invariantchain of immunoglobulines or antibodies as defined herein, signalsequences of Lamp1, Tapasin, Erp57, Calretikulin, Calnexin, and furthermembrane associated proteins or of proteins associated with theendoplasmic reticulum (ER) or the endosomal-lysosomal compartiment. Mostpreferably, signal sequences of MHC class I molecule HLA-A*0201 may beused according to the present invention. For example, a signal peptidederived from HLA-A is preferably used in order to promote secretion ofthe encoded antibody as defined herein or a fragment or variant thereof.More preferably, an HLA-A signal peptide is fused to an encoded antibodyas defined herein or to a fragment or variant thereof:

Any of the above modifications may be applied to the RNA of the presentinvention, and further to any RNA as used in the context of the presentinvention and may be, if suitable or necessary, be combined with eachother in any combination, provided, these combinations of modificationsdo not interfere with each other in the respective at least one mRNA. Aperson skilled in the art will be able to take his choice accordingly.

The RNA, preferably an mRNA, according to the invention, which comprisesat least one coding sequence as defined herein, may preferably comprisea 5′ UTR and/or a 3′ UTR preferably containing at least one histonestem-loop. Where, in addition to the antibody as defined herein or afragment or variant thereof, a further peptide or protein is encoded bythe at least one coding sequence of the RNA according to the invention,the encoded peptide or protein is preferably no histone protein, noreporter protein and/or no marker or selection protein, as definedherein. The 3′ UTR of the RNA according to the invention preferablycomprises also a poly(A) and/or a poly(C) sequence as defined herein.The single elements of the 3′ UTR may occur therein in any order from 5′to 3′ along the sequence of the RNA of the present invention. Inaddition, further elements as described herein, may also be contained,such as a stabilizing sequence as defined herein (e.g. derived from theUTR of a globin gene), IRES sequences, etc. Each of the elements mayalso be repeated in the RNA according to the invention at least once(particularly in di- or multicistronic constructs), preferably twice ormore. As an example, the single elements may be present in the RNAaccording to the invention in the following order:

5′—coding region—histone stem-loop—poly(A)/(C) sequence—3′; or

5′—coding region—poly(A)/(C) sequence—histone stem-loop—3′; or

5′—coding region—histone stem-loop—polyadenylation signal—3′; or

5′—coding region—polyadenylation signal—histone stem-loop—3′; or

5′—coding region—histone stem-loop—histone stem-loop—poly(A)/(C)sequence—3′; or

5′—coding region—histone stem-loop—histone stem-loop—polyadenylationsignal—3′; or

5′—coding region—stabilizing sequence—poly(A)/(C) sequence—histonestem-loop—3′; or

5′—coding region—stabilizing sequence—poly(A)/(C) sequence—poly(A)/(C)sequence—histone stem-loop—3′; etc.

According to a further embodiment, the RNA, preferably an mRNA, of thepresent invention preferably comprises at least one of the followingstructural elements: a 5′- and/or 3′-untranslated region element (UTRelement), particularly a 5′-UTR element, which preferably comprises orconsists of a nucleic acid sequence which is derived from the 5′-UTR ofa TOP gene or from a fragment, homolog or a variant thereof, or a 5′-and/or 3′-UTR element which may preferably be derivable from a gene thatprovides a stable mRNA or from a homolog, fragment or variant thereof; ahistone-stem-loop structure, preferably a histone-stem-loop in its 3′untranslated region; a 5′-cap structure; a poly-A tail; or a poly(C)sequence.

According to some embodiments, it is particularly preferred that—if, inaddition to an antibody as defined herein or a fragment or variantthereof, a further peptide or protein is encoded by the at least onecoding sequence as defined herein—the encoded peptide or protein ispreferably no histone protein, no reporter protein (e.g. Luciferase,GFP, EGFP, β-Galactosidase, particularly EGFP) and/or no marker orselection protein (e.g. alpha-Globin, Galactokinase and Xanthine:Guaninephosphoribosyl transferase (GPT)). In a preferred embodiment, the RNAaccording to the invention does not comprise a reporter gene or a markergene. Preferably, the RNA according to the invention does not encode,for instance, luciferase; green fluorescent protein (GFP) and itsvariants (such as eGFP, RFP or BFP); α-globin; hypoxanthine-guaninephosphoribosyltransferase (HGPRT); β-galactosidase; galactokinase;alkaline phosphatase; secreted embryonic alkaline phosphatase (SEAP)) ora resistance gene (such as a resistance gene against neomycin,puromycin, hygromycin and zeocin). In a preferred embodiment, the RNAaccording to the invention does not encode luciferase. In anotherembodiment, the RNA according to the invention does not encode GFP or avariant thereof.

According to a preferred embodiment, the RNA according to the presentinvention comprises, preferably in 5′ to 3′ direction, the followingelements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,    -   b) at least one coding sequence comprising or consisting of a        nucleic acid sequence selected from the group consisting of SEQ        ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,        61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,        61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,        61347, 61350-61356, 61358, 61360, 61363-61369, 61371,        61374-61380, 61382, 61386-61399, 61402-61404, 61416,        61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,        61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,        61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,        61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,        61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,        61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,        61662-61664, 61668-61674, 61676, 61679-61685, 61687,        61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,        61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,        61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,        61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,        61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,        61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,        61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,        61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,        61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,        61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,        61733, and 61734; or a fragment or variant thereof,    -   c) a poly(A) tail, preferably consisting of 10 to 200, 10 to        100, 40 to 80 or 50 to 70 adenosine nucleotides,    -   d) a poly(C) tail, preferably consisting of 10 to 200, 10 to        100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and    -   e) a histone stem-loop, preferably comprising the RNA sequence        according to SEQ ID NO: 61158.

More preferably, the RNA according to the invention comprises,preferably in 5′ to 3′ direction, the following elements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,    -   b) at least one coding sequence comprising or consisting of a        nucleic acid sequence selected from the group consisting of SEQ        ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,        61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,        61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,        61347, 61350-61356, 61358, 61360, 61363-61369, 61371,        61374-61380, 61382, 61386-61399, 61402-61404, 61416,        61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,        61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,        61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,        61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,        61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,        61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,        61662-61664, 61668-61674, 61676, 61679-61685, 61687,        61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,        61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,        61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,        61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,        61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,        61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,        61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,        61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,        61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,        61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,        61733, and 61734; or a fragment or variant thereof,    -   c) a 3′-UTR element comprising a nucleic acid sequence, which is        derived from an α-globin gene, preferably comprising the RNA        sequence according to SEQ ID NO: 61150, or a homolog, a fragment        or a variant thereof,    -   d) a poly(A) tail, preferably consisting of 10 to 200, 10 to        100, 40 to 80 or 50 to 70 adenosine nucleotides,    -   e) a poly(C) tail, preferably consisting of 10 to 200, 10 to        100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and    -   f) a histone stem-loop, preferably comprising the RNA sequence        according to SEQ ID NO: 61158.

In a further embodiment, the RNA according to the invention comprises,preferably in 5′ to 3′ direction, the following elements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,    -   b) a 5′-UTR element, which preferably comprises or consists of a        nucleic acid sequence, which is derived from the 5′-UTR of a TOP        gene, preferably comprising an RNA sequence corresponding to the        nucleic acid sequence according to SEQ ID NO: 61138, or a        homolog, a fragment or a variant thereof,    -   c) at least one coding sequence comprising or consisting of a        nucleic acid sequence selected from the group consisting of SEQ        ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,        61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,        61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,        61347, 61350-61356, 61358, 61360, 61363-61369, 61371,        61374-61380, 61382, 61386-61399, 61402-61404, 61416,        61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,        61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,        61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,        61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,        61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,        61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,        61662-61664, 61668-61674, 61676, 61679-61685, 61687,        61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,        61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,        61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,        61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,        61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,        61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,        61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,        61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,        61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,        61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,        61733, and 61734; or a fragment or variant thereof,    -   d) a 3′-UTR element comprising a nucleic acid sequence, which is        preferably derived from an α-globin gene, preferably comprising        the RNA sequence according to SEQ ID NO: 61150, or a homolog, a        fragment or a variant thereof; and/or        -   a 3′-UTR element comprising a nucleic acid sequence, which            is derived from an albumin gene, preferably comprising the            RNA sequence according to SEQ ID NO: 61154, or a homolog, a            fragment or a variant thereof or the RNA sequence according            to SEQ ID NO: 61156, or a homolog, a fragment or a variant            thereof,    -   e) a poly(A) tail, preferably consisting of 10 to 200, 10 to        100, 40 to 80 or 50 to 70 adenosine nucleotides,    -   f) a poly(C) tail, preferably consisting of 10 to 200, 10 to        100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and    -   g) a histone stem-loop, preferably comprising the RNA sequence        according to SEQ ID NO: 61158.

Moreover, it is also preferred that the RNA according to the inventioncomprises, preferably in 5′ to 3′ direction, the following elements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,    -   b) a 5′-UTR element, which preferably comprises or consists of a        nucleic acid sequence, which is derived from the 5′-UTR of a TOP        gene, preferably comprising an RNA sequence corresponding to the        nucleic acid sequence according to SEQ ID NO: 61142, or a        homolog, a fragment or a variant thereof,    -   c) at least one coding sequence comprising or consisting of a        nucleic acid sequence selected from the group consisting of SEQ        ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,        61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,        61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,        61347, 61350-61356, 61358, 61360, 61363-61369, 61371,        61374-61380, 61382, 61386-61399, 61402-61404, 61416,        61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,        61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,        61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,        61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,        61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,        61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,        61662-61664, 61668-61674, 61676, 61679-61685, 61687,        61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,        61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,        61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,        61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,        61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,        61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,        61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,        61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,        61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,        61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,        61733, and 61734; or a fragment or variant thereof,    -   d) a 3′-UTR element comprising a nucleic acid sequence, which is        preferably derived from an α-globin gene, preferably comprising        the RNA sequence according to SEQ ID NO: 61150, or a homolog, a        fragment or a variant thereof; and/or        -   a 3′-UTR element comprising a nucleic acid sequence, which            is derived from an albumin gene, preferably comprising the            RNA sequence according to SEQ ID NO: 61154, or a homolog, a            fragment or a variant thereof or the RNA sequence according            to SEQ ID NO: 61156, or a homolog, a fragment or a variant            thereof,    -   e) a poly(A) tail, preferably consisting of 10 to 200, 10 to        100, 40 to 80 or 50 to 70 adenosine nucleotides,    -   f) a poly(C) tail, preferably consisting of 10 to 200, 10 to        100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and    -   g) a histone stem-loop, preferably comprising the RNA sequence        according to SEQ ID NO: 61158.

Preferably, the RNA according to the present invention additionallycodes a tag for purification chosen from the group consisting of ahexahistidine tag (HIS tag, polyhistidine tag), a streptavidin tag(Strep tag), an SBP tag (streptavidin-binding tag) or a GST (glutathioneS-transferase) tag, or codes for a tag for purification via an antibodyepitope chosen from the group consisting of antibody-binding tags, a Myctag, a Swa11 epitope, a FLAG tag or an HA tag.

It is also preferred that the RNA according to the present inventionadditionally (in addition to the antibody or fragment or variantthereof) encodes a signal peptide and/or a localization sequence, inparticular a secretion sequence. Such signal peptides are (signal)sequences which conventionally comprise a length of from 15 to 30 aminoacids and are preferably localized on the N-terminus of the codedantibody. Signal peptides typically render possible transport of aprotein or peptide fused therewith (here e.g. an antibody) to or into adefined cell compartment, preferably the cell surface, the endoplasmicreticulum or the endosomal-lysosomal compartment. Examples of signalsequences which can be used according to the invention are e.g. signalsequences of conventional and non-conventional MHC molecules, cytokines,immunoglobulins, the invariant chain, Lamp1, tapasin, Erp57,calreticulin and calnexin, and all further membrane-located,endosomally-lysosomally or endoplasmic reticulum-associated proteins.The signal peptide of the human MHC class I molecule HLA-A*0201 ispreferably used.

Sequences which render possible transport of a protein or peptide fusedtherewith (here e.g. an antibody) to or into a defined cell compartment,preferably the cell surface, the nucleus, the nucleus region, the plasmamembrane, the cytosol, the endoplasmic reticulum, the organelles, themitochondria, the Golgi apparatus or the endosomal-lysosomalcompartment, also include, without being limited thereto, so-calledrouting signals, sorting signals, retention signals or salvage signalsand membrane topology-stop transfer signals (cf. Pugsley, A. P., ProteinTargeting, Academic Press, Inc. (1989)) at the level of the RNAaccording to the invention. In this connection, localization sequencesinclude nucleic acid sequences which encode e.g. signals, i.e. aminoacid sequences, such as, for example, KDEL (SEQ ID NO: 61176) (Munro, etal., Cell 48:899-907 (1987)) DDEL (SEQ ID NO: 61177), DEEL (SEQ ID NO:61178), QEDL (SEQ ID NO: 61179) and RDEL (SEQ ID NO: 61180)(Hangejorden, et al., J. Biol. Chem. 266:6015 (1991)) for theendoplasmic reticulum; PKKKRKV (SEQ ID NO: 61181) (Lanford, et al. Cell46:575 (1986)) PQKKIKS (SEQ ID NO: 61182) (Stanton, L. W., et al., Proc.Natl. Acad. Sci USA 83:1772 (1986); QPKKP (SEQ ID NO: 61183) (Harlow, etal., Mol. Cell Biol. 5:1605 1985), and RKKR (SEQ ID NO: 61184) for thenucleus; and RKKRRQRRRAHQ (SEQ ID NO: 61185) (Seomi, et al., J. Virology64:1803 (1990)), RQARRNRRRRWRERQR (SEQ ID NO: 61186) (Kubota, et al.,Biochem. and Biophy, Res. Comm. 162:963 (1989)), and MPLTRRRPAASQALAPPTP(SEQ ID NO: 61187) (Siomi, et al., Cell 55:197 (1988)) for the nucleusregion; MDDQRDLISNNEQLP (SEQ ID NO: 61188) (Bakke, et al., Cell63:707-716 (1990)) for the endosomal compartment (see, for example,Letourneur, et al., Cell 69:1183 (1992) for the targeting of liposomes).Myristoylation sequences can furthermore be used in order to lead theexpressed protein or peptide (here e.g. an antibody) to the plasmamembrane, or to certain various sub-cell compartments, such as thenucleus region, the organelles, the mitochondria and the Golgiapparatus. Corresponding amino acid sequences which are coded by acorresponding codon sequence of the RNA according to the invention aregiven below. The sequence MLFNLRXXLNNAAFRHGHNFMVRNFRCGQPLX (SEQ ID NO:61189) can be used to lead the antibody to the mitochondrial matrix(Pugsley, supra). See Tang, et al., J. Bio. Chem. 207:10122, in respectof the localization of proteins (antibodies) to the Golgi apparatus; forthe localization of proteins to the plasma membrane: GCVCSSNP (SEQ IDNO: 61190), GQTVTTPL (SEQ ID NO: 61191), GQELSQHE (SEQ ID NO: 61192),GNSPSYNP (SEQ ID NO: 61193), GVSGSKGQ (SEQ ID NO: 61194), GQTITTPL (SEQID NO: 61195), GQTLTTPL (SEQ ID NO: 61196), GQIFSRSA (SEQ ID NO: 61197),GQIHGLSP (SEQ ID NO: 61198), GARASVLS (SEQ ID NO: 61199), and GCTLSAEE(SEQ ID NO: 61200); to the endoplasmic reticulum GQNLSTSN (SEQ ID NO:61201); to the nucleus GAALTILV (SEQ ID NO: 61202) and GAALTLLG (SEQ IDNO: 61203); to the endoplasmic reticulum and to the cytoplasm GAQVSSQK(SEQ ID NO: 61204) and GAQLSRNT (SEQ ID NO: 61205); to the Golgiapparatus, to the nucleus, to the cytoplasm and to the cytoskeleton:GNAAAAKK (SEQ ID NO: 61206); to the cytoplasm and to the cytoskeletonGNEASYPL (SEQ ID NO: 61207); and to the plasma membrane and to thecytoskeleton GSSKSKPK (SEQ ID NO: 61208). Such sequences as describedabove are preferably used for RNAs which code for intrabodies, i.eantibodies which are retained in the cell and are not secreted. Thus,the localization sequence is preferably chosen from one of the sequencesaccording to SEQ ID NO: 61176 to 61208.

It is also preferred that the RNA according to the present inventioncomprises a nucleic acid sequence selected from the group consisting ofnucleic acid sequences according to SEQ ID NOs: 61243, 61244, 61276,61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348,61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463,61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486,61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603,61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613,61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688,61699, 61710, 61721, 61732, 61733, 61734.

The RNA according to the present invention may be prepared using anymethod known in the art, including synthetic methods such as e.g. solidphase RNA synthesis, as well as in vitro methods, such as RNA in vitrotranscription reactions.

Combination of at least Two Distinct RNA's

In a further aspect the present invention provides a combination of atleast two distinct RNA's as described above, preferably for use inmedicine. As used herein, the term “RNA's” refers in particular to “RNAspecies” (with one RNA species typically referring to one or moreidentical RNA molecules). Accordingly, the terms “RNA's” and “RNAspecies” may be used interchangeably. The term “distinct” refers inparticular to the coding sequence of the RNA. In other words, the atleast two distinct RNA's differ in particular in their coding sequences.Accordingly, the at least two distinct RNA's may relate to (encode) thesame or different antibodies. For example, the at least two distinctRNA's may encode two distinct antibodies or fragments or variantsthereof as described herein.

However, it is preferred that the at least two distinct RNA's encodedifferent fragments of the same antibody. In other words, an antibody(or a fragment or variant thereof as described herein) may be encoded(i) by one single RNA as described above or (ii) by at least twodistinct RNA's, wherein each of the distinct RNA's preferably encodes adistinct fragment of the antibody. More preferably, one RNA of the atleast two distinct RNA's encodes a heavy chain variable region of anantibody or a fragment thereof and another RNA of the at least twodistinct RNA's encodes the corresponding light chain variable region ofthe antibody or the fragment thereof. Even more preferably, one RNA ofthe at least two distinct RNA's encodes a heavy chain of an antibody andanother RNA of the at least two distinct RNA's encodes the correspondinglight chain of the antibody. Thereby, the term “corresponding” meansthat heavy and light chain (or heavy chain variable region and lightchain variable region) are from the same antibody (or from the samefragment or variant thereof). Accordingly, it is preferred that (i) theRNA according to the present invention as described above or (ii) thecombination of the at least two distinct RNA's according to the presentinvention as a whole encodes a functional antibody (or a functionalfragment or variant thereof) as described herein. In other words, anantibody (or a fragment or variant thereof), which is expressed by useof (i) the RNA according to the present invention as described above or(ii) the combination of the at least two distinct RNA's according to thepresent invention as a whole, is preferably a functional antibody (or afunctional fragment or variant thereof) as described herein.

Preferably, in such a combination of at least two distinct RNA's the RNAencoding the complete heavy chain, the heavy chain variable region, or afragment thereof, and the RNA encoding the complete light chain, thelight chain variable region, or a fragment thereof comprise identical3′UTR elements and/or identical 5′UTR elements. Preferred 3′UTRelements, 5′UTR elements and other structural features are the same asdescribed above for the RNA according to the present invention.

Particularly preferably, in a combination for use according to thepresent invention the distinct RNA's, in particular the RNA encoding thecomplete heavy chain, the heavy chain variable region, or a fragmentthereof, and the RNA encoding the complete light chain, the light chainvariable region, or a fragment thereof may comprise, preferably in 5′ to3′ direction, the following elements:

-   -   a) an identical 5′-CAP structure, preferably m7GpppN;    -   b) an identical 5′-UTR element, which preferably comprises or        consists of a nucleic acid sequence, which is derived from the        5′-UTR of a TOP gene, preferably comprising an RNA sequence        corresponding to the nucleic acid sequence according to SEQ ID        NO: 61138, or a homolog, a fragment or a variant thereof;    -   c) at least one coding sequence, which is distinct for the at        least two distinct RNA's comprised by the combination for use        according to the present invention;    -   d) an identical 3′-UTR element comprising a nucleic acid        sequence, which is preferably derived from an α-globin gene,        preferably comprising the RNA sequence according to SEQ ID NO:        61150, or a homolog, a fragment or a variant thereof; and/or        -   an identical 3′-UTR element comprising a nucleic acid            sequence, which is preferably derived from an albumin gene,            preferably comprising the RNA sequence according to SEQ ID            NO: 61154, or a homolog, a fragment or a variant thereof or            the RNA sequence according to SEQ ID NO: 61156, or a            homolog, a fragment or a variant thereof;    -   e) an identical poly(A) tail, preferably consisting of 10 to        200, 10 to 100, 40 to 80 or 50 to 70 adenosine nucleotides;    -   f) an identical poly(C) tail, preferably consisting of 10 to        200, 10 to 100, 20 to 70, 20 to 60 or 10 to 40 cytosine        nucleotides; and/or    -   g) an identical histone stem-loop, preferably comprising the RNA        sequence according to SEQ ID NO: 61158.

Most preferably, in a combination for use according to the presentinvention the distinct RNA's, in particular the RNA encoding thecomplete heavy chain, the heavy chain variable region, or a fragmentthereof, and the RNA encoding the complete light chain, the light chainvariable region, or a fragment thereof may comprise, preferably in 5′ to3′ direction, the following elements:

-   -   a) an identical 5′-CAP structure, preferably m7GpppN;    -   b) an identical 5′-UTR element, which preferably comprises or        consists of a nucleic acid sequence, which is derived from the        5′-UTR of a TOP gene, preferably comprising an RNA sequence        corresponding to the nucleic acid sequence according to SEQ ID        NO: 61142, or a homolog, a fragment or a variant thereof;    -   c) at least one coding sequence, which is distinct for the at        least two distinct RNA's comprised by the combination for use        according to the present invention; d) an identical 3′-UTR        element comprising a nucleic acid sequence, which is preferably        derived from an α-globin gene, preferably comprising the RNA        sequence according to SEQ ID NO: 61150, or a homolog, a fragment        or a variant thereof; and/or        -   an identical 3′-UTR element comprising a nucleic acid            sequence, which is preferably derived from an albumin gene,            preferably comprising the RNA sequence according to SEQ ID            NO: 61154, or a homolog, a fragment or a variant thereof or            the RNA sequence according to SEQ ID NO: 61156, or a            homolog, a fragment or a variant thereof;    -   e) an identical poly(A) tail, preferably consisting of 10 to        200, 10 to 100, 40 to 80 or 50 to 70 adenosine nucleotides;    -   f) an identical poly(C) tail, preferably consisting of 10 to        200, 10 to 100, 20 to 70, 20 to 60 or 10 to 40 cytosine        nucleotides; and/or    -   g) an identical histone stem-loop, preferably comprising the RNA        sequence according to SEQ ID NO: 61158.

Thereby, an optimal stoichiometric ratio of the amino acid sequencesencoded by the at least two RNA's can be achieved, which in turn resultsin optimal antibody formation.

In the combination of the at least to distinct RNA's as described hereinfor use according to the present invention, the at least to distinctRNA's as described herein may be administered separately or in the samecomposition.

In the combination of the at least to distinct RNA's as described hereinfor use according to the present invention, the at least to distinctRNA's as described herein are preferably administered at about the sametime.

“At about the same time”, as used herein, means in particularsimultaneous administration or that directly after administration of oneRNA the other RNA is administered. The skilled person understands that“directly after” includes the time necessary to prepare the secondadministration—in particular the time necessary for exposing anddisinfecting the location for the second administration as well asappropriate preparation of the “administration device” (e.g., syringe,pump, etc.). The term “simultaneous administration” as used herein alsoincludes if the periods of administration of the at least two distinctRNA's overlap or if, for example, one RNA is administered over a longerperiod of time, such as 30 min, 1 h, 2 h or even more, e.g. by infusion,and the other RNA is administered at some time during such a longperiod.

Alternatively, the at least two RNA's may be administered consecutively.However, it is preferred that the at least two distinct RNA's areadministered at the same day with the time between administration of thefirst RNA and administration of the second RNA being preferably no morethan 6 hours, more preferably no more than 3 hours, even more preferablyno more than 2 hours and most preferably no more than 1 h.

Preferably, the at least two distinct RNA's are administered in atherapeutically effective amount. A “therapeutically effective amount”,as used herein, is the amount which is sufficient for the alleviation ofthe symptoms of the disease or condition being treated and/or forprophylaxis of the symptoms of the disease or condition being prevented.In other words, a “therapeutically effective amount” means an amount ofthe at least two distinct RNA's that is sufficient to significantlyinduce a positive modification of a disease or disorder, i.e. an amountof the at least two distinct RNA's, that elicits the biological ormedicinal response in a tissue, system, animal or human that is beingsought. The term also includes the amount of the at least two distinctRNA's sufficient to reduce the progression of the disease, e.g., tonotably reduce or inhibit the tumor growth or infection and therebyelicit the response being sought, in particular such response could bean immune response involving the antibodies or antibody fragmentsencoded by the RNA according to the invention. At the same time,however, a “therapeutically effective amount” is preferably small enoughto avoid serious side-effects, that is to say to permit a sensiblerelationship between advantage and risk. The determination of theselimits typically lies within the scope of sensible medical judgment. A“therapeutically effective amount” of the at least two distinct RNA'swill furthermore vary in connection with the particular condition to betreated and also with the age and physical condition of the patient tobe treated, the body weight, general health, sex, diet, time ofadministration, rate of excretion, drug combination, the activity of theat least two distinct RNA's, the severity of the condition, the durationof the treatment, the nature of the accompanying therapy, of theparticular pharmaceutically acceptable carrier used, and similarfactors, within the knowledge and experience of the accompanying doctor.

In the combination of the at least to distinct RNA's as described hereinfor use according to the present invention, the at least to distinctRNA's as described herein may be administered via the same or differentroutes of administration. Preferably, the at least two distinct RNA'sare administered via the same route of administration. Preferred routesof administration are described below, in the context of the(pharmaceutical) composition. Those preferred routes of administrationapply accordingly for the combination for use according to the presentinvention.

In the combination of the at least to distinct RNA's as described hereinfor use according to the present invention, the at least to distinctRNA's as described herein may be provided in the same or in distinctcompositions. Preferably, the at least to distinct RNA's as describedherein are provided in the same composition. Compositions comprising theRNA according to the present invention are described in detail in thefollowing.

The combination of at least two distinct RNA's is preferably used forthe treatment (prevention and/or therapy) of a variety of diseases asdescribed below (in the context of the use of the RNA and thecomposition according to the invention and in the context of thetreatment method) in more detail. Those details and preferredembodiments apply accordingly for the combination for use according tothe present invention.

Composition comprising the RNA according to the Present Invention

In a further aspect, the present invention provides a compositioncomprising the RNA comprising at least one coding sequence as describedherein and a pharmaceutically acceptable carrier. The compositionaccording to the invention is preferably provided as a pharmaceuticalcomposition or as a (passive) vaccine. As used herein, the term “passivevaccine” refers to a vaccine for use in passive immunization.

According to a preferred embodiment, the (pharmaceutical) composition orthe (passive) vaccine according to the invention comprises the RNA ofthe present invention, wherein the at least one coding sequence of theRNA comprises or consists of a nucleic acid sequence encoding anantibody, or a fragment or variant of an antibody, wherein the antibodypreferably comprises or consists of an amino acid sequence selected fromthe group consisting of SEQ ID NO: 1-7642, 61212-61214, 61236-61238,61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324,61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384,61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456,61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493,61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543,61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603,61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644,61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700,61708, 61711, 61719, 61722, and 61730; or a fragment or variant of anyone of said amino acid sequences.

Preferably, the (pharmaceutical) composition or the (passive) vaccineaccording to the invention comprises the RNA of the present invention,wherein the at least one coding sequence of the RNA comprises orconsists of a nucleic acid sequence encoding an antibody, or a fragmentor variant of an antibody, wherein the antibody preferably comprises orconsists of an amino acid sequence having a sequence identity of atleast 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%,89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably ofat least 70%, more preferably of at least 80%, even more preferably atleast 85%, even more preferably of at least 90% and most preferably ofat least 95% or even 97%, with an amino acid sequence selected from thegroup consisting of SEQ ID NO: 1-7642, 61212-61214, 61236-61238,61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324,61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384,61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456,61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493,61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543,61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603,61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644,61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700,61708, 61711, 61719, 61722, and 61730; or a fragment or variant of anyone of said amino acid sequences.

More preferably, the (pharmaceutical) composition or the (passive)vaccine according to the invention comprises the RNA of the presentinvention, wherein the at least one coding sequence of the RNA comprisesor consists of a nucleic acid sequence encoding an antibody, or afragment or variant of an antibody, wherein the antibody preferablycomprises or consists of an amino acid sequence having a sequenceidentity of at least 80% with an amino acid sequence selected from thegroup consisting of SEQ ID NO: 1-7642, 61212-61214, 61236-61238,61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324,61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384,61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456,61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493,61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543,61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603,61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644,61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700,61708, 61711, 61719, 61722, and 61730; or a fragment or variant of anyone of said amino acid sequences.

In preferred embodiments, the (pharmaceutical) composition or the(passive) vaccine according to the invention comprises the RNA of thepresent invention, wherein the at least one coding sequence of the RNAcomprises or consists of a nucleic acid sequence selected from the groupconsisting of SEQ ID NO: 7643-61136, 61161-61175, 61209-61211,61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302,61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380,61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436,61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473,61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514,61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563,61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607,61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642,61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687,61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729,61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322,61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404,61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428,61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473,61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520,61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608,61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733,and 61734; or a fragment or variant of any of said nucleic acidsequences.

According to another embodiment, the (pharmaceutical) composition or the(passive) vaccine according to the invention comprises the RNA of thepresent invention, wherein the at least one coding sequence of the RNAcomprises or consists of a nucleic acid sequence having a sequenceidentity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%,86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%,preferably of at least 70%, more preferably of at least 80%, even morepreferably at least 85%, even more preferably of at least 90% and mostpreferably of at least 95% or even 97%, with a nucleic acid sequenceselected from the group consisting of SEQ ID NO: 7643-61136,61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268,61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331,61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360,61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416,61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459,61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491,61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541,61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585,61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636,61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676,61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718,61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361,61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415,61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466,61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492,61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605,61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615,61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710,61721, 61732, 61733, and 61734; or a fragment or variant of any one ofsaid nucleic acid sequences.

According to a particularly preferred embodiment, the (pharmaceutical)composition or the (passive) vaccine according to the inventioncomprises the RNA of the present invention, wherein the at least onecoding sequence of the RNA comprises or consists of a nucleic acidsequence having a sequence identity of at least 80% with a nucleic acidsequence selected from the group consisting of SEQ ID NO: 7643-61136,61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268,61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331,61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360,61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416,61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459,61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491,61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541,61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585,61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636,61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676,61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718,61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361,61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415,61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466,61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492,61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605,61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615,61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710,61721, 61732, 61733, and 61734; or a fragment or variant of any one ofsaid nucleic acid sequences.

In the context of the present invention, the RNA comprised by the(pharmaceutical) composition or the (passive) vaccine may encode one ormore of the antibodies defined herein or a fragment or variant thereof.

The (pharmaceutical) composition or (passive) vaccine according to theinvention may thus comprise the RNA of the present invention, whereinthe RNA encodes one specific antibody of the antibodies defined hereinor a fragment or a variant thereof. In that embodiment, the(pharmaceutical) composition or (passive) vaccine preferably comprisesthe RNA according to the invention comprising the at least one codingsequence as described herein encoding the antibody or a fragment orvariant thereof.

Alternatively, the (pharmaceutical) composition or (passive) vaccine ofthe present invention may comprise at least one RNA according to theinvention, wherein the at least one RNA encodes at least two, three,four, five, six, seven, eight, nine, ten, eleven or twelve distinctantibodies as defined herein or a fragment or variant thereof.Preferably, the (pharmaceutical) composition or the (passive) vaccinecomprises several classes of the RNA according to the invention, whereineach RNA species encodes one of the antibodies or a fragment or variantthereof. In another embodiment, the RNA comprised in the(pharmaceutical) composition or (passive) vaccine is a bi- ormulticistronic RNA as defined herein, which encodes the at least two,three, four, five, six, seven, eight, nine, ten, eleven or twelvedistinct antibodies or fragments or variants thereof. Mixtures betweenthese embodiments are also envisaged, such as compositions comprisingmore than one RNA species, wherein at least one RNA species may bemonocistronic, while at least one other RNA species may be bi- ormulticistronic.

The RNA according to the present invention as described above, inparticular the RNA comprised in the (pharmaceutical) composition or the(passive) vaccine according to the present invention, may thus compriseany combination of the nucleic acid sequences as defined herein.

In a particularly preferred embodiment, the composition according to thepresent invention comprises at least two distinct RNA's according to thepresent inventions. Thereby, the details of the at least two distinctRNA's according to the present inventions as described above, in thecontext of the combination for use according to the present invention,apply accordingly for the at least two distinct RNA's comprised in thecomposition according to the present invention. Accordingly, it ispreferred that one RNA of the at least two distinct RNA's encodes aheavy chain variable region of an antibody or a fragment thereof andanother RNA of the at least two distinct RNA's encodes the correspondinglight chain variable region of the antibody or the fragment thereof.More preferably, one RNA of the at least two distinct RNA's encodes aheavy chain of an antibody and another RNA of the at least two distinctRNA's encodes the corresponding light chain of the antibody. It is alsopreferred that the RNA encoding the heavy chain variable region or afragment thereof and the RNA encoding the light chain variable region ora fragment thereof comprise identical 5′UTR elements and/or identical3′UTR elements and/or identical further elements as described above, inthe context of the combination for use according to the presentinvention.

In a preferred embodiment of the composition according to the invention,the RNA is complexed with one or more cationic or polycationiccompounds, preferably with cationic or polycationic polymers, cationicor polycationic peptides or proteins, e.g. protamine, cationic orpolycationic polysaccharides and/or cationic or polycationic lipids.

According to a preferred embodiment, the RNA of the compositionaccording to the present invention may be complexed with lipids to formone or more liposomes, lipoplexes, or lipid nanoparticles. Therefore, inone embodiment, the inventive composition comprises liposomes,lipoplexes, and/or lipid nanoparticles comprising the at least one mRNA.

Lipid-based formulations have been increasingly recognized as one of themost promising delivery systems for RNA due to their biocompatibilityand their ease of large-scale production. Cationic lipids have beenwidely studied as synthetic materials for delivery of RNA. After mixingtogether, nucleic acids are condensed by cationic lipids to formlipid/nucleic acid complexes known as lipoplexes. These lipid complexesare able to protect genetic material from the action of nucleases anddeliver it into cells by interacting with the negatively charged cellmembrane.

Lipoplexes can be prepared by directly mixing positively charged lipidsat physiological pH with negatively charged nucleic acids.

Conventional liposomes consist of a lipid bilayer that can be composedof cationic, anionic, or neutral (phospho)lipids and cholesterol, whichencloses an aqueous core. Both the lipid bilayer and the aqueous spacecan incorporate hydrophobic or hydrophilic compounds, respectively.Liposome characteristics and behaviour in vivo can be modified byaddition of a hydrophilic polymer coating, e.g. polyethylene glycol(PEG), to the liposome surface to confer steric stabilization.Furthermore, liposomes can be used for specific targeting by attachingligands (e.g., antibodies, peptides, and carbohydrates) to its surfaceor to the terminal end of the attached PEG chains (Front Pharmacol. 2015Dec. 1; 6:286).

Liposomes are colloidal lipid-based and surfactant-based deliverysystems composed of a phospholipid bilayer surrounding an aqueouscompartment. They may present as spherical vesicles and can range insize from 20 nm to a few microns. Cationic lipid-based liposomes areable to complex with negatively charged nucleic acids via electrostaticinteractions, resulting in complexes that offer biocompatibility, lowtoxicity, and the possibility of the large-scale production required forin vivo clinical applications. Liposomes can fuse with the plasmamembrane for uptake; once inside the cell, the liposomes are processedvia the endocytic pathway and the genetic material is then released fromthe endosome/carrier into the cytoplasm. Liposomes have long beenperceived as drug delivery vehicles because of their superiorbiocompatibility, given that liposomes are basically analogs ofbiological membranes, and can be prepared from both natural andsynthetic phospholipids (Int J Nanomedicine. 2014; 9: 1833-1843).

Cationic liposomes have been traditionally the most commonly usednon-viral delivery systems for oligonucleotides, including plasmid DNA,antisense oligos, and siRNA/small hairpin RNA-shRNA). Cationic lipids,such as DOTAP, (1,2-dioleoyl-3-trimethylammonium-propane) and DOTMA(N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethyl-ammonium methyl sulfate)can form complexes or lipoplexes with negatively charged nucleic acidsto form nanoparticles by electrostatic interaction, providing high invitro transfection efficiency. Furthermore, neutral lipid-basednanoliposomes for RNA delivery as e.g. neutral1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC)-based nanoliposomeswere developed. (Adv Drug Deliv Rev. 2014 February; 66: 110-116.).

Therefore, in one embodiment the RNA of the composition according to thepresent invention is complexed with cationic lipids and/or neutrallipids and thereby forms liposomes, lipid nanoparticles, lipoplexes orneutral lipid-based nanoliposomes.

In a preferred embodiment, the composition according to the inventioncomprises the RNA according to the invention that is formulated togetherwith a cationic or polycationic compound and/or with a polymericcarrier. Accordingly, in a further embodiment of the invention, it ispreferred that the RNA as defined herein or any other nucleic acidcomprised in the inventive (pharmaceutical) composition or (passive)vaccine is associated with or complexed with a cationic or polycationiccompound or a polymeric carrier, optionally in a weight ratio selectedfrom a range of about 6:1 (w/w) to about 0.25:1 (w/w), more preferablyfrom about 5:1 (w/w) to about 0.5:1 (w/w), even more preferably of about4:1 (w/w) to about 1:1 (w/w) or of about 3:1 (w/w) to about 1:1 (w/w),and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w) ofmRNA or nucleic acid to cationic or polycationic compound and/or with apolymeric carrier; or optionally in a nitrogen/phosphate (N/P) ratio ofmRNA or nucleic acid to cationic or polycationic compound and/orpolymeric carrier in the range of about 0.1-10, preferably in a range ofabout 0.3-4 or 0.3-1, and most preferably in a range of about 0.5-1 or0.7-1, and even most preferably in a range of about 0.3-0.9 or 0.5-0.9.More preferably, the N/P ratio of the at least one mRNA to the one ormore polycations is in the range of about 0.1 to 10, including a rangeof about 0.3 to 4, of about 0.5 to 2, of about 0.7 to 2 and of about 0.7to 1.5.

Therein, the RNA as defined herein or any other nucleic acid comprisedin the (pharmaceutical) composition or (passive) vaccine according tothe invention can also be associated with a vehicle, transfection orcomplexation agent for increasing the transfection efficiency and/or theimmunostimulatory properties of the RNA according to the invention or ofoptionally comprised further included nucleic acids.

Cationic or polycationic compounds, being particularly preferred agentsin this context include protamine, nucleoline, spermine or spermidine,or other cationic peptides or proteins, such as poly-L-lysine (PLL),poly-arginine, basic polypeptides, cell penetrating peptides (CPPs),including HIV-binding peptides, HIV-1 Tat (HIV), Tat-derived peptides,Penetratin, VP22 derived or analog peptides, HSV VP22 (Herpes simplex),MAP, KALA or protein transduction domains (PTDs), PpT620, prolin-richpeptides, arginine-rich peptides, lysine-rich peptides, MPG-peptide(s),Pep-1, L-oligomers, Calcitonin peptide(s), Antennapedia-derived peptides(particularly from Drosophila antennapedia), pAntp, plsl, FGF,Lactoferrin, Transportan, Buforin-2, Bac715-24, SynB, SynB(1), pVEC,hCT-derived peptides, SAP, or histones. More preferably, the RNAaccording to the invention is complexed with one or more polycations,preferably with protamine or oligofectamine, most preferably withprotamine. In this context protamine is particularly preferred.

Additionally, preferred cationic or polycationic proteins or peptidesmay be selected from the following proteins or peptides having thefollowing total formula (III):(Arg)_(l);(Lys)_(m);(His)_(n);(Orn)_(o);(Xaa)_(x),  (formula (III))

wherein l+m+n+o+x=8-15, and l, m, nor o independently of each other maybe any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,13, 14 or 15, provided that the overall content of Arg, Lys, His and Ornrepresents at least 50% of all amino acids of the oligopeptide; and Xaamay be any amino acid selected from native (=naturally occurring) ornon-native amino acids except of Arg, Lys, His or Orn; and x may be anynumber selected from 0, 1, 2, 3 or 4, provided, that the overall contentof Xaa does not exceed 50% of all amino acids of the oligopeptide.Particularly preferred cationic peptides in this context are e.g. Arg₇,Arg₈, Arg₉, H₃R₉, R₉H₃, H₃R₉H₃, YSSR₉SSY, (RKH)₄, Y(RKH)₂R, etc. In thiscontext the disclosure of WO 2009/030481 is incorporated herewith byreference.

Further preferred cationic or polycationic compounds, which can be usedas transfection or complexation agent may include cationicpolysaccharides, for example chitosan, polybrene, cationic polymers,e.g. polyethyleneimine (PEI), cationic lipids, e.g. DOTMA:[1-(2,3-sioleyloxy)propyl)]-N,N,N-trimethylammonium chloride, DMRIE,di-C14-amidine, DOTIM, SAINT, DC-Chol, BGTC, CTAP, DOPC, DODAP, DOPE:Dioleyl phosphatidylethanol-amine, DOSPA, DODAB, DOIC, DMEPC, DOGS:Dioctadecylamidoglicylspermin, DIMRI: Dimyristo-oxypropyl dimethylhydroxyethyl ammonium bromide, DOTAP:dioleoyloxy-3-(trimethylammonio)propane, DC-6-14:O,O-ditetradecanoyl-N-(α-trimethylammonioacetyl)diethanolamine chloride,CLIP1: rac-[(2,3-dioctadecyloxypropyl)(2-hydroxyethyl)]-dimethylammoniumchloride, CLIP6:rac-[2(2,3-dihexadecyloxypropyl-oxymethyloxy)ethyl]trimethylammonium,CLIP9:rac-[2(2,3-dihexadecyloxypropyl-oxysuccinyloxy)ethyl]-trimethylammonium,oligofectamine, or cationic or polycationic polymers, e.g. modifiedpolyaminoacids, such as β-aminoacid-polymers or reversed polyamides,etc., modified polyethylenes, such as PVP(poly(N-ethyl-4-vinylpyridinium bromide)), etc., modified acrylates,such as pDMAEMA (poly(dimethylaminoethyl methylacrylate)), etc.,modified amidoamines such as pAMAM (poly(amidoamine)), etc., modifiedpolybetaaminoester (PBAE), such as diamine end modified 1,4 butanedioldiacrylate-co-5-amino-1-pentanol polymers, etc., dendrimers, such aspolypropylamine dendrimers or pAMAM based dendrimers, etc.,polyimine(s), such as PEI: poly(ethyleneimine), poly(propyleneimine),etc., polyallylamine, sugar backbone based polymers, such ascyclodextrin based polymers, dextran based polymers, chitosan, etc.,silan backbone based polymers, such as PMOXA-PDMS copolymers, etc.,blockpolymers consisting of a combination of one or more cationic blocks(e.g. selected from a cationic polymer as mentioned above) and of one ormore hydrophilic or hydrophobic blocks (e.g. polyethyleneglycole); etc.

According to a preferred embodiment, the composition of the presentinvention comprises the RNA as defined herein and a polymeric carrier. Apolymeric carrier used according to the invention might be a polymericcarrier formed by disulfide-crosslinked cationic components. Thedisulfide-crosslinked cationic components may be the same or differentfrom each other. The polymeric carrier can also contain furthercomponents. It is also particularly preferred that the polymeric carrierused according to the present invention comprises mixtures of cationicpeptides, proteins or polymers and optionally further components asdefined herein, which are crosslinked by disulfide bonds as describedherein. In this context, the disclosure of WO 2012/013326 isincorporated herewith by reference.

In this context, the cationic components, which form basis for thepolymeric carrier by disulfide-crosslinkage, are typically selected fromany suitable cationic or polycationic peptide, protein or polymersuitable for this purpose, particular any cationic or polycationicpeptide, protein or polymer capable of complexing the RNA as definedherein or a further nucleic acid comprised in the composition, andthereby preferably condensing the RNA or the nucleic acid. The cationicor polycationic peptide, protein or polymer, is preferably a linearmolecule, however, branched cationic or polycationic peptides, proteinsor polymers may also be used.

Every disulfide-crosslinking cationic or polycationic protein, peptideor polymer of the polymeric carrier, which may be used to complex theRNA according to the invention or any further nucleic acid comprised inthe (pharmaceutical) composition or (passive) vaccine of the presentinvention contains at least one —SH moiety, most preferably at least onecysteine residue or any further chemical group exhibiting an —SH moiety,capable of forming a disulfide linkage upon condensation with at leastone further cationic or polycationic protein, peptide or polymer ascationic component of the polymeric carrier as mentioned herein.

As defined above, the polymeric carrier, which may be used to complexthe RNA of the present invention or any further nucleic acid comprisedin the (pharmaceutical) composition or (passive) vaccine according tothe invention may be formed by disulfide-crosslinked cationic (orpolycationic) components. Preferably, such cationic or polycationicpeptides or proteins or polymers of the polymeric carrier, whichcomprise or are additionally modified to comprise at least one —SHmoiety, are selected from, proteins, peptides and polymers as definedherein for complexation agent.

In a further particular embodiment, the polymeric carrier which may beused to complex the RNA as defined herein or any further nucleic acidcomprised in the (pharmaceutical) composition or (passive) vaccineaccording to the invention may be selected from a polymeric carriermolecule according to generic formula (IV):L-P¹-S-[S-P²-S]_(n)-S-P³-L  formula (IV)

wherein,

-   P¹ and P³ are different or identical to each other and represent a    linear or branched hydrophilic polymer chain, each P¹ and P³    exhibiting at least one —SH-moiety, capable to form a disulfide    linkage upon condensation with component P², or alternatively with    (AA), (AA)_(x), or [(AA)_(x)]_(z) if such components are used as a    linker between P¹ and P² or P³ and P²) and/or with further    components (e.g. (AA), (AA)_(x), [(AA)_(x)]_(z) or L), the linear or    branched hydrophilic polymer chain selected independent from each    other from polyethylene glycol (PEG),    poly-N-(2-hydroxypropyl)methacrylamide,    poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl    L-asparagine), poly(2-(methacryloyloxy)ethyl phosphorylcholine),    hydroxyethylstarch or poly(hydroxyalkyl L-glutamine), wherein the    hydrophilic polymer chain exhibits a molecular weight of about 1 kDa    to about 100 kDa, preferably of about 2 kDa to about 25 kDa; or more    preferably of about 2 kDa to about 10 kDa, e.g. about 5 kDa to about    25 kDa or 5 kDa to about 10 kDa;-   P² is a cationic or polycationic peptide or protein, e.g. as defined    above for the polymeric carrier formed by disulfide-crosslinked    cationic components, and preferably having a length of about 3 to    about 100 amino acids, more preferably having a length of about 3 to    about 50 amino acids, even more preferably having a length of about    3 to about 25 amino acids, e.g. a length of about 3 to 10, 5 to 15,    10 to 20 or 15 to 25 amino acids, more preferably a length of about    5 to about 20 and even more preferably a length of about 10 to about    20; or    -   is a cationic or polycationic polymer, e.g. as defined above for        the polymeric carrier formed by disulfide-crosslinked cationic        components, typically having a molecular weight of about 0.5 kDa        to about 30 kDa, including a molecular weight of about 1 kDa to        about 20 kDa, even more preferably of about 1.5 kDa to about 10        kDa, or having a molecular weight of about 0.5 kDa to about 100        kDa, including a molecular weight of about 10 kDa to about 50        kDa, even more preferably of about 10 kDa to about 30 kDa; each        P² exhibiting at least two —SH-moieties, capable to form a        disulfide linkage upon condensation with further components P²        or component(s) P¹ and/or P³ or alternatively with further        components (e.g. (AA), (AA)_(x), or [(AA)_(x)]_(z));-   —S—S— is a (reversible) disulfide bond (the brackets are omitted for    better readability), wherein S preferably represents sulphur or a    —SH carrying moiety, which has formed a (reversible) disulfide bond.    The (reversible) disulfide bond is preferably formed by condensation    of —SH-moieties of either components P¹ and P², P² and P², or P² and    P³, or optionally of further components as defined herein (e.g. L,    (AA), (AA)_(x), [(AA)_(x)]_(z), etc); The —SH-moiety may be part of    the structure of these components or added by a modification as    defined below;-   L is an optional ligand, which may be present or not, and may be    selected independent from the other from RGD, Transferrin, Folate, a    signal peptide or signal sequence, a localization signal or    sequence, a nuclear localization signal or sequence (NLS), an    antibody, a cell penetrating peptide, (e.g. TAT or KALA), a ligand    of a receptor (e.g. cytokines, hormones, growth factors etc), small    molecules (e.g. carbohydrates like mannose or galactose or synthetic    ligands), small molecule agonists, inhibitors or antagonists of    receptors (e.g. RGD peptidomimetic analogues), or any further    protein as defined herein, etc.;-   n is an integer, typically selected from a range of about 1 to 50,    preferably from a range of about 1, 2 or 3 to 30, more preferably    from a range of about 1, 2, 3, 4, or 5 to 25, or a range of about 1,    2, 3, 4, or 5 to 20, or a range of about 1, 2, 3, 4, or 5 to 15, or    a range of about 1, 2, 3, 4, or 5 to 10, including e.g. a range of    about 4 to 9, 4 to 10, 3 to 20, 4 to 20, 5 to 20, or 10 to 20, or a    range of about 3 to 15, 4 to 15, 5 to 15, or 10 to 15, or a range of    about 6 to 11 or 7 to 10. Most preferably, n is in a range of about    1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3,    or 4 to 9, in a range of about 1, 2, 3, or 4 to 8, or in a range of    about 1, 2, or 3 to 7.

In this context, the disclosure of WO 2011/026641 is incorporatedherewith by reference. Each of hydrophilic polymers P¹ and P³ typicallyexhibits at least one —SH-moiety, wherein the at least one —SH-moiety iscapable to form a disulfide linkage upon reaction with component P² orwith component (AA) or (AA)_(x), if used as linker between P¹ and P² orP³ and P² as defined below and optionally with a further component, e.g.L and/or (AA) or (AA)_(x), e.g. if two or more —SH-moieties arecontained. The following subformulae “P¹—S—S—P²” and “P²—S—S—P³” withingeneric formula (IV) above (the brackets are omitted for betterreadability), wherein any of S, P¹ and P³ are as defined herein,typically represent a situation, wherein one-SH-moiety of hydrophilicpolymers P¹ and P³ was condensed with one —SH-moiety of component P² ofgeneric formula (IV) above, wherein both sulphurs of these —SH-moietiesform a disulfide bond —S—S— as defined herein in formula (IV). These—SH-moieties are typically provided by each of the hydrophilic polymersP¹ and P³, e.g. via an internal cysteine or any further (modified) aminoacid or compound which carries a —SH moiety. Accordingly, thesubformulae “P¹—S—S—P²” and “P²—S—S—P³” may also be written as“P¹-Cys-Cys-P²” and “P²-Cys-Cys-P³”, if the —SH-moiety is provided by acysteine, wherein the term Cys-Cys represents two cysteines coupled viaa disulfide bond, not via a peptide bond. In this case, the term “—S—S—”in these formulae may also be written as “—S-Cys”, as “-Cys-S” or as“-Cys-Cys-”. In this context, the term “-Cys-Cys-” does not represent apeptide bond but a linkage of two cysteines via their —SH-moieties toform a disulfide bond. Accordingly, the term “-Cys-Cys-” also may beunderstood generally as “-(Cys-S)—(S-Cys)-”, wherein in this specificcase S indicates the sulphur of the —SH-moiety of cysteine. Likewise,the terms “—S-Cys” and “-Cys-S” indicate a disulfide bond between a —SHcontaining moiety and a cysteine, which may also be written as“—S—(S-Cys)” and “-(Cys-S)—S”. Alternatively, the hydrophilic polymersP¹ and P³ may be modified with a —SH moiety, preferably via a chemicalreaction with a compound carrying a —SH moiety, such that each of thehydrophilic polymers P¹ and P³ carries at least one such —SH moiety.Such a compound carrying a —SH moiety may be e.g. an (additional)cysteine or any further (modified) amino acid, which carries a —SHmoiety. Such a compound may also be any non-amino compound or moiety,which contains or allows to introduce a —SH moiety into hydrophilicpolymers P¹ and P³ as defined herein. Such non-amino compounds may beattached to the hydrophilic polymers P¹ and P³ of formula (IV) of thepolymeric carrier according to the present invention via chemicalreactions or binding of compounds, e.g. by binding of a 3-thio propionicacid or thioimolane, by amide formation (e.g. carboxylic acids,sulphonic acids, amines, etc), by Michael addition (e.g maleinimidemoieties, α,β-unsatured carbonyls, etc), by click chemistry (e.g. azidesor alkines), by alkene/alkine methatesis (e.g. alkenes or alkines),imine or hydrozone formation (aldehydes or ketons, hydrazins,hydroxylamins, amines), complexation reactions (avidin, biotin, proteinG) or components which allow S_(n)-type substitution reactions (e.ghalogenalkans, thiols, alcohols, amines, hydrazines, hydrazides,sulphonic acid esters, oxyphosphonium salts) or other chemical moietieswhich can be utilized in the attachment of further components. Aparticularly preferred PEG derivate in this context isalpha-Methoxy-omega-mercapto poly(ethylene glycol). In each case, theSH-moiety, e.g. of a cysteine or of any further (modified) amino acid orcompound, may be present at the terminal ends or internally at anyposition of hydrophilic polymers P¹ and P³. As defined herein, each ofhydrophilic polymers P¹ and P³ typically exhibits at least one—SH-moiety preferably at one terminal end, but may also contain two oreven more —SH-moieties, which may be used to additionally attach furthercomponents as defined herein, preferably further functional peptides orproteins e.g. a ligand, an amino acid component (AA) or (AA)_(x),antibodies, cell penetrating peptides or enhancer peptides (e.g. TAT,KALA), etc.

Preferably, the inventive composition comprises at least one RNA asdefined herein, which is complexed with one or more polycations, and atleast one free RNA, wherein the at least one complexed RNA is preferablyidentical to the at least one free RNA. In this context, it isparticularly preferred that the composition of the present inventioncomprises the RNA according to the invention that is complexed at leastpartially with a cationic or polycationic compound and/or a polymericcarrier, preferably cationic proteins or peptides. In this context, thedisclosure of WO 2010/037539 and WO 2012/113513 is incorporated herewithby reference. Partially means that only a part of the RNA as definedherein is complexed in the composition according to the invention with acationic compound and that the rest of the RNA as defined herein is(comprised in the inventive (pharmaceutical) composition or (passive)vaccine) in uncomplexed form (“free”). Preferably, the molar ratio ofthe complexed RNA to the free RNA is selected from a molar ratio ofabout 0.001:1 to about 1:0.001, including a ratio of about 1:1. Morepreferably the ratio of complexed RNA to free RNA (in the(pharmaceutical) composition or (passive) vaccine of the presentinvention) is selected from a range of about 5:1 (w/w) to about 1:10(w/w), more preferably from a range of about 4:1 (w/w) to about 1:8(w/w), even more preferably from a range of about 3:1 (w/w) to about 1:5(w/w) or 1:3 (w/w), and most preferably the ratio of complexed mRNA tofree mRNA in the inventive pharmaceutical composition or (passive)vaccine is selected from a ratio of about 1:1 (w/w).

The complexed RNA in the (pharmaceutical) composition or (passive)vaccine according to the present invention, is preferably preparedaccording to a first step by complexing the RNA according to theinvention with a cationic or polycationic compound and/or with apolymeric carrier, preferably as defined herein, in a specific ratio toform a stable complex. In this context, it is highly preferable, that nofree cationic or polycationic compound or polymeric carrier or only anegligibly small amount thereof remains in the component of thecomplexed RNA after complexing the RNA. Accordingly, the ratio of theRNA and the cationic or polycationic compound and/or the polymericcarrier in the component of the complexed RNA is typically selected in arange so that the RNA is entirely complexed and no free cationic orpolycationic compound or polymeric carrier or only a negligibly smallamount thereof remains in the composition.

Preferably the ratio of the RNA as defined herein to the cationic orpolycationic compound and/or the polymeric carrier, preferably asdefined herein, is selected from a range of about 6:1 (w/w) to about0.25:1 (w/w), more preferably from about 5:1 (w/w) to about 0.5:1 (w/w),even more preferably of about 4:1 (w/w) to about 1:1 (w/w) or of about3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1(w/w) to about 2:1 (w/w). Alternatively, the ratio of the RNA as definedherein to the cationic or polycationic compound and/or the polymericcarrier, preferably as defined herein, in the component of the complexedmRNA, may also be calculated on the basis of the nitrogen/phosphateratio (N/P-ratio) of the entire complex. In the context of the presentinvention, an N/P-ratio is preferably in the range of about 0.1-10,preferably in a range of about 0.3-4 and most preferably in a range ofabout 0.5-2 or 0.7-2 regarding the ratio of RNA: cationic orpolycationic compound and/or polymeric carrier, preferably as definedherein, in the complex, and most preferably in a range of about 0.7-1.5,0.5-1 or 0.7-1, and even most preferably in a range of about 0.3-0.9 or0.5-0.9, preferably provided that the cationic or polycationic compoundin the complex is a cationic or polycationic cationic or polycationicprotein or peptide and/or the polymeric carrier as defined above. Inthis specific embodiment the complexed RNA as defined herein is alsoencompassed in the term “adjuvant component”.

In other embodiments, the composition according to the inventioncomprising the RNA as defined herein may be administered naked withoutbeing associated with any further vehicle, transfection or complexationagent.

It has to be understood and recognized, that according to the presentinvention, the inventive composition may comprise at least one naked RNAas defined herein, preferably an mRNA, and/or at least oneformulated/complexed RNA as defined herein, preferably an mRNA, whereinevery formulation and/or complexation as disclosed above may be used.

In a further aspect, the present invention provides a (passive) vaccine,which is based on the RNA according to the invention comprising at leastone coding sequence as defined herein. The (passive) vaccine accordingto the invention is preferably a (pharmaceutical) composition as definedherein.

Accordingly, the (passive) vaccine according to the invention is basedon the same components as the (pharmaceutical) composition describedherein. Insofar, it may be referred to the description of the(pharmaceutical) composition as provided herein. In particular, inembodiments, where the (passive) vaccine comprises more than one RNAcomponent (such as a plurality of RNAs according to the invention,wherein each encodes a distinct antibody or, preferably, distinctfragments of the same antibody), the (passive) vaccine may, however, beprovided in physically separate form and may be administered by separateadministration steps, for example as described above in the context of acombination for use according to the present invention. The (passive)vaccine according to the invention may correspond to the(pharmaceutical) composition as described herein, especially where themRNA components are provided by one single composition. However, theinventive (passive) vaccine may also be provided physically separated.For instance, in embodiments, wherein the (passive) vaccine comprisesmore than one RNA (e.g. as described above in the context of acombination for use according to the present invention), these RNA's maybe provided such that, for example, two, three, four, five or sixseparate compositions, which may contain at least one RNA species each(e.g. three distinct mRNA species), each encoding distinct antibodies ordistinct fragments of the same antibody, are provided, which may or maynot be combined. Also, the inventive (passive) vaccine may be acombination of at least two distinct compositions, each compositioncomprising at least one mRNA encoding at least one of the antibodies asdefined herein or encoding at least one fragment of an antibody.Alternatively, the (passive) vaccine may be provided as a combination ofat least one mRNA, preferably at least two, three, four, five, six ormore mRNAs, each encoding one of the antibodies defined herein or onefragment of the same antibody. The (passive) vaccine may be combined toprovide one single composition prior to its use or it may be used suchthat more than one administration is required to administer the distinctmRNA species encoding any of the antibody combinations as defined hereinor encoding any of the antibody fragment combinations as defined herein(such as, for example, heavy and light chain of the same antibodyencoded by distinct mRNA's). If the (passive) vaccine contains at leastone mRNA molecule, typically at least two mRNA molecules, encoding anantibody combination or an antibody fragment combination as definedherein, it may e.g. be administered by one single administration(combining all mRNA species), by at least two separate administrations.Accordingly; any combination of mono-, bi- or multicistronic mRNAsencoding the at least one antibody or any combination of antibodies orof antibody fragments as defined herein (and optionally furtherantibodies), provided as separate entities (containing one mRNA species)or as combined entity (containing more than one mRNA species), isunderstood as a (passive) vaccine according to the present invention.According to a preferred embodiment of the inventive (passive) vaccine,the at least one antibody or the fragment thereof, preferably acombination as defined herein of at least two, three, four, five, six ormore antibodies or fragments thereof encoded by the inventivecomposition as a whole, is provided as an individual (monocistronic)mRNA, which is administered separately.

As with the (pharmaceutical) composition according to the presentinvention, the entities of the (passive) vaccine may be provided inliquid and or in dry (e.g. lyophilized) form. They may contain furthercomponents, in particular further components allowing for itspharmaceutical use. The (passive) vaccine or the (pharmaceutical)composition may, e.g., additionally contain a pharmaceuticallyacceptable carrier and/or further auxiliary substances and additivesand/or adjuvants.

The (passive) vaccine or (pharmaceutical) composition typicallycomprises a safe and effective amount of the RNA according to theinvention as defined herein, encoding an antibody or a fragment orvariant thereof as defined herein or a combination of antibodies asdefined herein. As used herein, “safe and effective amount” means anamount of the RNA that is sufficient to significantly induce a positivemodification of a disease or disorder to be treated with the inventivecomposition. At the same time, however, a “safe and effective amount” issmall enough to avoid serious side-effects, that is to say to permit asensible relationship between advantage and risk. The determination ofthese limits typically lies within the scope of sensible medicaljudgment. In relation to the (passive) vaccine or (pharmaceutical)composition of the present invention, the expression “safe and effectiveamount” preferably means an amount of the RNA (and thus of the encodedantibody or fragment thereof) that is suitable for treating a disease ordisorder as described herein. Such a “safe and effective amount” of theRNA of the (pharmaceutical) composition or (passive) vaccine as definedherein may furthermore be selected in dependence of the type of RNA,e.g. monocistronic, bi- or even multicistronic RNA, since a bi- or evenmulticistronic RNA may lead to a significantly higher expression of theencoded antibody(s) than the use of an equal amount of a monocistronicRNA. A “safe and effective amount” of the RNA of the (pharmaceutical)composition or (passive) vaccine as defined above will furthermore varyin connection with the particular condition to be treated and also withthe age and physical condition of the patient to be treated, theseverity of the condition, the duration of the treatment, the nature ofthe accompanying therapy, of the particular pharmaceutically acceptablecarrier used, and similar factors, within the knowledge and experienceof the accompanying doctor. The (passive) vaccine or compositionaccording to the invention can be used according to the invention forhuman and also for veterinary medical purposes, as a pharmaceuticalcomposition or as a (passive) vaccine.

In a preferred embodiment, the RNA of the (pharmaceutical) composition,(passive) vaccine or kit of parts according to the invention is providedin lyophilized form. Preferably, the lyophilized RNA is reconstituted ina suitable buffer, advantageously based on an aqueous carrier, prior toadministration, e.g. Ringer-Lactate solution, which is preferred, Ringersolution, a phosphate buffer solution. In a preferred embodiment, the(pharmaceutical) composition, the (passive) vaccine or the kit of partsaccording to the invention contains at least two, three, four, five, sixor more RNAs, preferably mRNAs which are provided separately inlyophilized form (optionally together with at least one furtheradditive) and which are preferably reconstituted separately in asuitable buffer (such as Ringer-Lactate solution) prior to their use soas to allow individual administration of each of the (monocistronic)RNAs.

The (passive) vaccine or (pharmaceutical) composition according to theinvention may typically contain a pharmaceutically acceptable carrier.The expression “pharmaceutically acceptable carrier” as used hereinpreferably includes the liquid or non-liquid basis of the inventive(passive) vaccine. If the inventive (passive) vaccine is provided inliquid form, the carrier will be water, typically pyrogen-free water;isotonic saline or buffered (aqueous) solutions, e.g phosphate, citrateetc. buffered solutions. Particularly for injection of the inventive(passive) vaccine, water or preferably a buffer, more preferably anaqueous buffer, may be used, containing a sodium salt, preferably atleast 50 mM of a sodium salt, a calcium salt, preferably at least 0.01mM of a calcium salt, and optionally a potassium salt, preferably atleast 3 mM of a potassium salt. According to a preferred embodiment, thesodium, calcium and, optionally, potassium salts may occur in the formof their halogenides, e.g. chlorides, iodides, or bromides, in the formof their hydroxides, carbonates, hydrogen carbonates, or sulfates, etc.Without being limited thereto, examples of sodium salts include e.g.NaCl, NaI, NaBr, Na₂CO₃, NaHCO₃, Na₂SO₄, examples of the optionalpotassium salts include e.g. KCl, KI, KBr, K₂CO₃, KHCO₃, K₂SO₄, andexamples of calcium salts include e.g. CaCl₂, CaI₂, CaBr₂, CaCO₃, CaSO₄,Ca(OH)₂. Furthermore, organic anions of the aforementioned cations maybe contained in the buffer. According to a more preferred embodiment,the buffer suitable for injection purposes as defined above, may containsalts selected from sodium chloride (NaCl), calcium chloride (CaCl₂) andoptionally potassium chloride (KCl), wherein further anions may bepresent additional to the chlorides. CaCl₂ can also be replaced byanother salt like KCl. Typically, the salts in the injection buffer arepresent in a concentration of at least 50 mM sodium chloride (NaCl), atleast 3 mM potassium chloride (KCl) and at least 0.01 mM calciumchloride (CaCl₂). The injection buffer may be hypertonic, isotonic orhypotonic with reference to the specific reference medium, i.e. thebuffer may have a higher, identical or lower salt content with referenceto the specific reference medium, wherein preferably such concentrationsof the afore mentioned salts may be used, which do not lead to damage ofcells due to osmosis or other concentration effects. Reference media aree.g. in “in vivo” methods occurring liquids such as blood, lymph,cytosolic liquids, or other body liquids, or e.g. liquids, which may beused as reference media in “in vitro” methods, such as common buffers orliquids. Such common buffers or liquids are known to a skilled person.Ringer-Lactate solution is particularly preferred as a liquid basis.

However, one or more compatible solid or liquid fillers or diluents orencapsulating compounds may be used as well, which are suitable foradministration to a person. The term “compatible” as used herein meansthat the constituents of the inventive (passive) vaccine are capable ofbeing mixed with the RNA according to the invention as defined herein,in such a manner that no interaction occurs, which would substantiallyreduce the pharmaceutical effectiveness of the inventive (passive)vaccine under typical use conditions. Pharmaceutically acceptablecarriers, fillers and diluents must, of course, have sufficiently highpurity and sufficiently low toxicity to make them suitable foradministration to a person to be treated. Some examples of compoundswhich can be used as pharmaceutically acceptable carriers, fillers orconstituents thereof are sugars, such as, for example, lactose, glucose,trehalose and sucrose; starches, such as, for example, corn starch orpotato starch; dextrose; cellulose and its derivatives, such as, forexample, sodium carboxymethylcellulose, ethylcellulose, celluloseacetate; powdered tragacanth; malt; gelatin; tallow; solid glidants,such as, for example, stearic acid, magnesium stearate; calcium sulfate;vegetable oils, such as, for example, groundnut oil, cottonseed oil,sesame oil, olive oil, corn oil and oil from theobroma; polyols, suchas, for example, polypropylene glycol, glycerol, sorbitol, mannitol andpolyethylene glycol; alginic acid.

The choice of a pharmaceutically acceptable carrier is determined, inprinciple, by the manner, in which the pharmaceutical composition or(passive) vaccine according to the invention is administered. Thecomposition or (passive) vaccine can be administered, for example,systemically or locally. Routes for systemic administration in generalinclude, for example, transdermal, oral, parenteral routes, includingsubcutaneous, intravenous, intramuscular, intraarterial, intradermal andintraperitoneal injections and/or intranasal administration routes.Routes for local administration in general include, for example, topicaladministration routes but also intradermal, transdermal, subcutaneous,or intramuscular injections or intralesional, intracranial,intrapulmonal, intracardial, and sublingual injections. More preferably,composition or (passive) vaccines according to the present invention maybe administered by an intradermal, subcutaneous, or intramuscular route,preferably by injection, which may be needle-free and/or needleinjection. Compositions/vaccines are therefore preferably formulated inliquid or solid form. The suitable amount of the vaccine or compositionaccording to the invention to be administered can be determined byroutine experiments, e.g. by using animal models. Such models include,without implying any limitation, rabbit, sheep, mouse, rat, dog andnon-human primate models. Preferred unit dose forms for injectioninclude sterile solutions of water, physiological saline or mixturesthereof. The pH of such solutions should be adjusted to about 7.4.Suitable carriers for injection include hydrogels, devices forcontrolled or delayed release, polylactic acid and collagen matrices.Suitable pharmaceutically acceptable carriers for topical applicationinclude those which are suitable for use in lotions, creams, gels andthe like. If the inventive composition or vaccine is to be administeredperorally, tablets, capsules and the like are the preferred unit doseform. The pharmaceutically acceptable carriers for the preparation ofunit dose forms which can be used for oral administration are well knownin the prior art. The choice thereof will depend on secondaryconsiderations such as taste, costs and storability, which are notcritical for the purposes of the present invention, and can be madewithout difficulty by a person skilled in the art.

Further additives which may be included in the inventive vaccine orcomposition are emulsifiers, such as, for example, Tween; wettingagents, such as, for example, sodium lauryl sulfate; colouring agents;taste-imparting agents, pharmaceutical carriers; tablet-forming agents;stabilizers; antioxidants; preservatives.

Kit comprising the RNA according to the Present Invention

According to another aspect of the present invention, the presentinvention also provides a kit, in particular a kit of parts, comprisingthe RNA according to the present invention, the (pharmaceutical)composition, and/or the vaccine according to the invention, optionally aliquid vehicle for solubilising and optionally technical instructionswith information on the administration and dosage of the RNA, thecomposition and/or the vaccine. The technical instructions may containinformation about administration and dosage of the RNA, the compositionand/or the vaccine. Such kits, preferably kits of parts, may be appliede.g. for any of the applications or uses as described herein, preferablyfor the use of the RNA according to the invention (for the preparationof an inventive medicament, preferably a vaccine), for the treatment(prophylaxis or therapy) of a disease or disorder as described herein.The kits may also be applied for the use of the RNA, the composition orthe vaccine as defined herein (for the preparation of an inventivevaccine) for the treatment (prophylaxis or therapy) of a disease ordisorder as described herein. Such kits may further be applied for theuse of the RNA, the composition or the vaccine as defined herein (forthe preparation of an inventive vaccine) for modulating, preferably foreliciting, e.g. to induce or enhance, an immune response in a mammal asdefined above, and preferably for supporting treatment (prophylaxis ortherapy) of a disease or disorder as described herein. Kits of parts, asa special form of kits, may contain one or more identical or differentcompositions and/or one or more identical or different vaccines asdescribed herein in different parts of the kit. Kits of parts may alsocontain an (e.g. one) composition, an (e.g. one) vaccine and/or the RNAaccording to the invention in different parts of the kit, e.g. each partof the kit containing an RNA as defined herein, preferably encoding adistinct antibody or distinct fragments of the same antibody.Preferably, the kit or the kit of parts contains as a part a vehicle forsolubilising the RNA according to the invention, the vehicle preferablybeing Ringer-lactate solution. Any of the above kits may be used in atreatment or prophylaxis as defined above.

In a further embodiment, the kit according to the present invention mayadditionally contain at least one further pharmaceutically activecomponent, preferably a therapeutic compound suitable for treatment(prophylaxis or therapy) of a disease or disorder as described herein.Moreover, in another embodiment, the kit may additionally contain partsand/or devices necessary or suitable for the administration of thecomposition or the vaccine according to the invention, includingneedles, applicators, patches, injection-devices.

Preferably, the kit according to the present invention contains, inparticular as a part, Ringer-Lactate solution. It is also preferred thatthe kit according to the present invention contains, in particular as apart, at least one modulator of an inhibitory and/or a stimulatorycheckpoint molecule, such as an inhibitor of an inhibitory checkpointmolecule, preferably CTLA4 inhibitors and PD-1 pathway inhibitors.

Moreover, in a particularly preferred embodiment, the kit according tothe present invention contains, in particular as distinct parts, atleast two distinct RNA's according to the present invention. Thereby,the details of the at least two distinct RNA's according to the presentinvention as described above, in the context of the combination for useaccording to the present invention, apply accordingly for the at leasttwo distinct RNA's contained in the kit according to the presentinvention. Accordingly, it is preferred that one RNA of the at least twodistinct RNA's encodes a heavy chain variable region of an antibody or afragment thereof and another RNA of the at least two distinct RNA'sencodes the corresponding light chain variable region of the antibody orthe fragment thereof. More preferably, one RNA of the at least twodistinct RNA's encodes a heavy chain of an antibody and another RNA ofthe at least two distinct RNA's encodes the corresponding light chain ofthe antibody. It is also preferred that the RNA encoding the heavy chainvariable region or a fragment thereof and the RNA encoding the lightchain variable region or a fragment thereof comprise identical 5′UTRelements and/or identical 3′UTR elements and/or identical furtherelements as described above, in the context of the combination for useaccording to the present invention.

Uses and methods according to the Present Invention

According to a further aspect of the present invention, the RNA, thecombination of RNA's according to the present invention, the(pharmaceutical) composition, the (passive) vaccine or the kit accordingto the present invention may be used (for the preparation of amedicament) for the treatment (prophylaxis or therapy) of anydisorder/disease, which can be treated by use of an antibody, inparticular cancer, cardiovascular diseases, neurological diseases,infectious diseases, autoimmune diseases, virus diseases, monogeneticdiseases and diseases or disorders related thereto. Preferably, the RNA,the combination of RNA's, the (pharmaceutical) composition, the(passive) vaccine or the kit according to the present invention may beused (for the preparation of a medicament) for the treatment(prophylaxis or therapy) of cancer or infectious diseases.

As used herein, the term “cancer” refers to the broad class of disordersand malignancies characterized by hyperproliferative cell growth, eitherin vitro (e.g., transformed cells) or in vivo. Conditions which can betreated or prevented by the compositions and methods of the inventioninclude, e.g., a variety of neoplasms, including benign or malignanttumours, a variety of hyperplasias, or the like. Compositions andmethods of the invention can achieve the inhibition and/or reversion ofundesired hyperproliferative cell growth involved in such conditions.Specific examples of cancers to be treated in the context of the presentinvention include Acute Lymphoblastic Leukemia, Adult; AcuteLymphoblastic Leukemia, Childhood; Acute Myeloid Leukemia, Adult;Adrenocortical Carcinoma; Adrenocortical Carcinoma, Childhood;AIDS-Related Lymphoma; AIDS-Related Malignancies; Anal Cancer;Astrocytoma, Childhood Cerebellar; Astrocytoma, Childhood Cerebral; BileDuct Cancer, Extrahepatic; Bladder Cancer; Bladder Cancer, Childhood;Bone Cancer, Osteosarcoma/Malignant Fibrous Histiocytoma; Brain StemGlioma, Childhood; Brain Tumor, Adult; Brain Tumor, Brain Stem Glioma,Childhood; Brain Tumor, Cerebellar Astrocytoma, Childhood; Brain Tumor,Cerebral Astrocytoma/Malignant Glioma, Childhood; Brain Tumor,Ependymoma, Childhood; Brain Tumor, Medulloblastoma, Childhood; BrainTumor, Supratentorial Primitive Neuroectodermal Tumors, Childhood; BrainTumor, Visual Pathway and Hypothalamic Glioma, Childhood; Brain Tumor,Childhood (Other); Breast Cancer; Breast Cancer and Pregnancy; BreastCancer, Childhood; Breast Cancer, Male; Bronchial Adenomas/Carcinoids,Childhood: Carcinoid Tumor, Childhood; Carcinoid Tumor,Gastrointestinal; Carcinoma, Adrenocortical; Carcinoma, Islet Cell;Carcinoma of Unknown Primary; Central Nervous System Lymphoma, Primary;Cerebellar Astrocytoma, Childhood; Cerebral Astrocytoma/MalignantGlioma, Childhood; Cervical Cancer; Childhood Cancers; ChronicLymphocytic Leukemia; Chronic Myelogenous Leukemia; ChronicMyeloproliferative Disorders; Clear Cell Sarcoma of Tendon Sheaths;Colon Cancer; Colorectal Cancer, Childhood; Cutaneous T-Cell Lymphoma;Endometrial Cancer; Ependymoma, Childhood; Epithelial Cancer, Ovarian;Esophageal Cancer; Esophageal Cancer, Childhood; Ewing's Family ofTumors; Extracranial Germ Cell Tumor, Childhood; Extragonadal Germ CellTumor; Extrahepatic Bile Duct Cancer; Eye Cancer, Intraocular Melanoma;Eye Cancer, Retinoblastoma; Gallbladder Cancer; Gastric (Stomach)Cancer; Gastric (Stomach) Cancer, Childhood; Gastrointestinal CarcinoidTumor; Germ Cell Tumor, Extracranial, Childhood; Germ Cell Tumor,Extragonadal; Germ Cell Tumor, Ovarian; Gestational Trophoblastic Tumor;Glioma. Childhood Brain Stem; Glioma. Childhood Visual Pathway andHypothalamic; Hairy Cell Leukemia; Head and Neck Cancer; Hepatocellular(Liver) Cancer, Adult (Primary); Hepatocellular (Liver) Cancer,Childhood (Primary); Hodgkin's Lymphoma, Adult; Hodgkin's Lymphoma,Childhood; Hodgkin's Lymphoma During Pregnancy; Hypopharyngeal Cancer;Hypothalamic and Visual Pathway Glioma, Childhood; Intraocular Melanoma;Islet Cell Carcinoma (Endocrine Pancreas); Kaposi's Sarcoma; KidneyCancer; Laryngeal Cancer; Laryngeal Cancer, Childhood; Leukemia, AcuteLymphoblastic, Adult; Leukemia, Acute Lymphoblastic, Childhood;Leukemia, Acute Myeloid, Adult; Leukemia, Acute Myeloid, Childhood;Leukemia, Chronic Lymphocytic; Leukemia, Chronic Myelogenous; Leukemia,Hairy Cell; Lip and Oral Cavity Cancer; Liver Cancer, Adult (Primary);Liver Cancer, Childhood (Primary); Lung Cancer, Non-Small Cell; LungCancer, Small Cell; Lymphoblastic Leukemia, Adult Acute; LymphoblasticLeukemia, Childhood Acute; Lymphocytic Leukemia, Chronic; Lymphoma,AIDS—Related; Lymphoma, Central Nervous System (Primary); Lymphoma,Cutaneous T-Cell; Lymphoma, Hodgkin's, Adult; Lymphoma, Hodgkin's;Childhood; Lymphoma, Hodgkin's During Pregnancy; Lymphoma,Non-Hodgkin's, Adult; Lymphoma, Non-Hodgkin's, Childhood; Lymphoma,Non-Hodgkin's During Pregnancy; Lymphoma, Primary Central NervousSystem; Macroglobulinemia, Waldenstrom's; Male Breast Cancer; MalignantMesothelioma, Adult; Malignant Mesothelioma, Childhood; MalignantThymoma; Medulloblastoma, Childhood; Melanoma; Melanoma, Intraocular;Merkel Cell Carcinoma; Mesothelioma, Malignant; Metastatic Squamous NeckCancer with Occult Primary; Multiple Endocrine Neoplasia Syndrome,Childhood; Multiple Myeloma/Plasma Cell Neoplasm; Mycosis Fungoides;Myelodysplasia Syndromes; Myelogenous Leukemia, Chronic; MyeloidLeukemia, Childhood Acute; Myeloma, Multiple; MyeloproliferativeDisorders, Chronic; Nasal Cavity and Paranasal Sinus Cancer;Nasopharyngeal Cancer; Nasopharyngeal Cancer, Childhood; Neuroblastoma;Neurofibroma; Non-Hodgkin's Lymphoma, Adult; Non-Hodgkin's Lymphoma,Childhood; Non-Hodgkin's Lymphoma During Pregnancy; Non-Small Cell LungCancer; Oral Cancer, Childhood; Oral Cavity and Lip Cancer;Oropharyngeal Cancer; Osteosarcoma/Malignant Fibrous Histiocytoma ofBone; Ovarian Cancer, Childhood; Ovarian Epithelial Cancer; Ovarian GermCell Tumor; Ovarian Low Malignant Potential Tumor; Pancreatic Cancer;Pancreatic Cancer, Childhood', Pancreatic Cancer, Islet Cell; ParanasalSinus and Nasal Cavity Cancer; Parathyroid Cancer; Penile Cancer;Pheochromocytoma; Pineal and Supratentorial Primitive NeuroectodermalTumors, Childhood; Pituitary Tumor; Plasma Cell Neoplasm/MultipleMyeloma; Pleuropulmonary Blastoma; Pregnancy and Breast Cancer;Pregnancy and Hodgkin's Lymphoma; Pregnancy and Non-Hodgkin's Lymphoma;Primary Central Nervous System Lymphoma; Primary Liver Cancer, Adult;Primary Liver Cancer, Childhood; Prostate Cancer; Rectal Cancer; RenalCell (Kidney) Cancer; Renal Cell Cancer, Childhood; Renal Pelvis andUreter, Transitional Cell Cancer; Retinoblastoma; Rhabdomyosarcoma,Childhood; Salivary Gland Cancer; Salivary Gland'Cancer, Childhood;Sarcoma, Ewing's Family of Tumors; Sarcoma, Kaposi's; Sarcoma(Osteosarcoma)/Malignant Fibrous Histiocytoma of Bone; Sarcoma,Rhabdomyosarcoma, Childhood; Sarcoma, Soft Tissue, Adult; Sarcoma, SoftTissue, Childhood; Sezary Syndrome; Skin Cancer; Skin Cancer, Childhood;Skin Cancer (Melanoma); Skin Carcinoma, Merkel Cell; Small Cell LungCancer; Small Intestine Cancer; Soft Tissue Sarcoma, Adult; Soft TissueSarcoma, Childhood; Squamous Neck Cancer with Occult Primary,Metastatic; Stomach (Gastric) Cancer; Stomach (Gastric) Cancer,Childhood; Supratentorial Primitive Neuroectodermal Tumors, Childhood;T-Cell Lymphoma, Cutaneous; Testicular Cancer; Thymoma, Childhood;Thymoma, Malignant; Thyroid Cancer; Thyroid Cancer, Childhood;Transitional Cell Cancer of the Renal Pelvis and Ureter; TrophoblasticTumor, Gestational; Unknown Primary Site, Cancer of, Childhood; UnusualCancers of Childhood; Ureter and Renal Pelvis, Transitional Cell Cancer;Urethral Cancer; Uterine Sarcoma; Vaginal Cancer; Visual Pathway andHypothalamic Glioma, Childhood; Vulvar Cancer; Waldenstrom's Macroglobulinemia; and Wilms' Tumor.

Infectious diseases are typically caused by pathogenic microorganisms,such as bacteria, viruses, parasites or fungi. Infectious diseases canusually be spread, directly or indirectly, from one person to another.Infectious diseases to be treated in the context of the presentinvention preferably include viral, retroviral, bacterial orprotozoological infectious diseases. Specific examples of infectiousdiseases to be treated in the context of the present invention includeinfluenza, malaria, SARS, yellow fever, AIDS, Lyme borreliosis,leishmaniasis, anthrax, meningitis, viral infectious diseases, such asAIDS, condyloma acuminata, molluscum contagiosum, dengue fever,three-day fever, Ebola virus, colds, early summer meningoencephalitis(ESME), influenza, shingles, hepatitis, herpes simplex type I, herpessimplex type II, herpes zoster, influenza, Japanese encephalitis, Lassafever, Marburg virus, measles, foot and mouth disease, mononucleosis,mumps, Norwalk virus infection, Pfeiffer's glandular fever, smallpox,polio (poliomyelitis), pseuodcroup, infectious erythema, rabies, warts,West Nile fever, chicken-pox, cytomegalovirus (CMV), bacterialinfectious diseases, such as abortion (infectious, septic), prostatitis(prostate inflammation), anthrax, appendicitis (inflammation of thecaecum), borreliosis, botulism, Campylobacter, Chlamydia trachomatis(inflammation of the urethra, conjunctiva), cholera, diphtheria,donavonosis, epiglottitis, louse-borne typhus, typhoid fever, gasgangrene, gonorrhoea, hare plague, Helicobacter pylori, whooping-cough,climatic bubo, osteomyelitis, legionnaires' disease, leprosy,listeriosis, pneumonia, meningitis, bacterial meningitis, anthrax,inflammation of the middle ear, Mycoplasma hominis, neonatal sepsis(chorioamnionitis), noma, paratyphoid fever, plague, Reiter's syndrome,Rocky Mountain spotted fever, Salmonella paratyphoid fever, Salmonellatyphoid fever, scarlet fever, syphilis, tetanus, gonorrhoea,tsutsugamushi fever, tuberculosis, typhus, vaginitis (colpitis), softchancre, and infectious diseases caused by parasites, protozoa or fungi,such as amoebic dysentery, bilharziosis, Chagas' disease, Echinococcus,fish tapeworm, ichthyotoxism (ciguatera), fox tapeworm, mycosis pedis,dog tapeworm, candiosis, ptyriasis, the itch (scabies), cutaneousleishmaniasis, lamblian dysentery (giadiasis), lice, malaria,onchocercosis (river blindness), fungal diseases, beef tapeworm,schistosomiasis, sleeping sickness, pork tapeworm, toxoplasmosis,trichomoniasis, trypanosomiasis (sleeping sickness), visceralleishmaniasis, nappy dermatitis, or infections caused by the dwarftapeworm.

The term “cardiovascular disease” as used herein typically includes anydisorders/diseases of the cardiovascular system. Specific examples ofcardiovascular diseases include coronary heart disease,arteriosclerosis, apoplexy and hypertension. The term “neurologicaldisease” as used herein typically includes disorders/diseases of thenervous system. Specific examples of neurological diseases includeAlzheimer's disease, amyotrophic lateral sclerosis, dystonia, epilepsy,multiple sclerosis and Parkinson's disease.

The term “autoimmune disease” as used herein typically refers to apathological state rising from an abnormal immune response of the bodyto substances and tissues that are normally present in the body.Specific examples of autoimmune diseases include autoimmune type Idiseases or autoimmune type II diseases or autoimmune type III diseasesor autoimmune type IV diseases, such as, for example, multiple sclerosis(MS), rheumatoid arthritis, diabetes, diabetes type I (diabetesmellitus), systemic lupus erythematosus (SLE), chronic polyarthritis,Basedow's disease, autoimmune forms of chronic hepatitis, colitisulcerosa, allergy type I diseases, allergy type II diseases, allergytype III diseases, allergy type IV diseases, fibromyalgia, hair loss,Bechterew's disease, Crohn's disease, myasthenia gravis,neurodermatitis, polymyalgia rheumatica, progressive systemic sclerosis(PSS), psoriasis, Reiter's syndrome, rheumatic arthritis, psoriasis orvasculitis.

It is particularly preferred that the RNA, the combination of RNA'saccording to the present invention, the (pharmaceutical) composition,the (passive) vaccine or the kit according to the present invention maybe used (for the preparation of a medicament) for the treatment(prophylaxis or therapy) of any disorder/disease, which is related tothe antibody, or the fragment thereof, encoded by the RNA. Particularlypreferably, the antibody is any of the antibodies listed in Table 11below. In this case, it is most preferred that the disease, disorder orcondition to be treated and/or prevented is any disease, disorder orcondition related to the antibody, in particular as described in Table11 below.

TABLE 11 Antibodies, their targets and diseases, disorders or conditionsrelated to the antibodies. Antibody Name Target Related Disease,Disorder or Condition AAB-003 Amyloid Beta Peptide; A beta P; Abeta;Beta Alzheimer's Disease Amyloid Abagovomab Tumour Antigen; CA-125Epithelial Ovarian Cancer; Ovarian Cancer Abciximab Integrin Alpha 2b;GPalpha IIb; Platelet Ischemia; Percutaneous Coronary Intervention;Unstable Membrane Glycoprotein IIb; CD41; ITGA2B Angina MyocardialInfarction; Myocardial Ischemia; Percutaneous Coronary Intervention;Unstable Angina Abituzumab Integrin Alpha V; Vitronectin ReceptorSubunit Interstitial Lung Diseases (Diffuse Parenchymal Lung Disease)Alpha; CD51; ITGAV Advanced Malignancy; Metastatic Cancer; Solid Tumor;Metastatic Colorectal Cancer; Metastatic Hormone Refractory (CastrationResistant; androgen-Independent) Prostate Cancer; Ovarian Cancer; CancerAbrilumab Integrin Alpha 4; CD49 Antigen Like Family Crohn's Disease(Regional Enteritis); Ulcerative Colitis; Member D; VLA4 Subunit Alpha;CD49d; ITGA4; Inflammatory Bowel Disease Integrin Beta 7; Gut HomingReceptor Beta Subunit; ITGB7; integrin α4β7 Actoxumab Clostridiumdifficile Toxin A; toxA; EC 3.4.22. Clostridium difficile Infections(Clostridium difficile Associated Disease); Clostridium difficileColitis Adalimumab Tumor Necrosis Factor; Cachectin; TNF Alpha;Intermediate Uveitis; Posterior Uveitis; Uveitis Crohn's Tumor NecrosisFactor Ligand Superfamily Disease (Regional Enteritis); UlcerativeColitis; Plaque Member 2; TNF a; TNF; TNFa; TNF-α Psoriasis (PsoriasisVulgaris); Rheumatoid Arthritis; Ankylosing Spondylitis (Bekhterev'sDisease); Polyarticular Juvenile Idiopathic Arthritis (PJIA); Crohn'sDisease (Regional Enteritis); Psoriasis; Hidradenitis Suppurative; AxialSpondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis (PJIA);Psoriatic Arthritis; Behcet Disease; Ulcerative Colitis; PolyarticularJuvenile Idiopathic Arthritis (PJIA); Interstitial Cystitis (PainfulBladder Syndrome); Ankylosing Spondylitis (Bekhterev's Disease); AxialSpondyloarthritis Spondyloarthritis (Spondyloarthropathy); AutoimmuneDisease; Hemolytic disease of the newborn Adrecizumab AdrenomedullinSeptic Shock Aducanumab Amyloid Beta Peptide; A beta P; Abeta; BetaAlzheimer's Disease Amyloid Afasevikumab Interleukin 17; IL17; IL17A;IL17F Autoimmune Disorders Aflibercept Placenta Growth Factor; VascularEndothelial Age Related Macular Degeneration; Branch Retinal Vein GrowthFactor Related Protein; PGF; Vascular Occlusion; Central Retinal VeinOcclusion; Macular Edema; Wet Endothelial Growth Factor A; Vascular(Neovascular/Exudative) Macular Degeneration; Choroidal PermeabilityFactor; VEGFA; Vascular Neovascularization; Myopia; Diabetic MacularEdema; Diabetic Endothelial Growth Factor B; VEGF Related Retinopathy;Central Retinal Vein Occlusion; Macular Edema; Factor; VEGFB Wet(Neovascular/Exudative) Macular Degeneration; Diabetic Macular Edema;Branch Retinal Vein Occlusion; Central Retinal Vein Occlusion; ChoroidalNeovascularization; Macular Edema; Wet (Neovascular/Exudative) MacularDegeneration; Age Related Macular Degeneration; Central Retinal VeinOcclusion; Choroidal Neovascularization; Macular Edema; Wet(Neovascular/Exudative) Macular Degeneration; Branch Retinal VeinOcclusion; Central Retinal Vein Occlusion; Macular Edema; Wet(Neovascular/Exudative) Macular Degeneration; Branch Retinal VeinOcclusion; Central Retinal Vein Occlusion; Macular Edema; Wet(Neovascular/Exudative) Macular Degeneration; Branch Retinal VeinOcclusion; Central Retinal Vein Occlusion; Choroidal Neovascularization;Macular Edema; Myopia; Wet (Neovascular/Exudative) Macular Degeneration;Choroidal Neovascularization; Macular Edema; Wet (Neovascular/Exudative)Macular Degeneration; Age Related Macular Degeneration; Central RetinalVein Occlusion; Choroidal Neovascularization; Macular Edema; Wet(Neovascular/Exudative) Macular Degeneration; Neovascular Glaucoma;Non-Proliferative Diabetic Retinopathy (NPDR); Optic Neuropathy;Retinopathy; Corneal Neovascularization Afutuzumab, B Lymphocyte AntigenCD20; B Lymphocyte Chronic Lymphocytic Leukemia (CLL); FollicularLymphoma; Obinutuzumab Surface Antigen B1; Bp35; Leukocyte SurfaceNon-Hodgkin Lymphoma; Lupus Nephritis; Diffuse Large B-Cell Antigen Leu16; Membrane Spanning 4 Lymphoma; Follicular Lymphoma; Splenic MarginalZone B-Cell Domains Subfamily A Member 1; CD20; MS4A1 Lymphoma;End-Stage Kidney Disease (End-Stage Renal Disease; ESRD); Graft VersusHost Disease (GVHD); Diffuse Large B-Cell Lymphoma; Follicular Lymphoma;Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed ChronicLymphocytic Leukemia (CLL) Waldenstrom Macroglobulinemia; Diffuse LargeB-Cell Lymphoma; Alacizumab, Vascular Endothelial Growth Factor ReceptorNon-Small Cell Lung Cancer Alacizumab 2; Fetal Liver Kinase I; KinaseInsert Domain pegol Receptor; Protein Tyrosine Kinase Receptor flk 1;VEGFR2; CD309; KDR; EC 2.7.10.1 Alemtuzumab CAMPATH 1 Antigen; CDw52;Cambridge Progressive Relapsing Multiple Sclerosis (PRMS); RelapsingPathology 1 Antigen; Epididymal Secretory Remitting Multiple Sclerosis(RRMS); B-Cell Chronic Protein E5; Human Epididymis Specific LymphocyticLeukemia; Peripheral T-Cell Lymphomas (PTCL); Protein 5; CD52 T-CellLeukemia Graft Versus Host Disease (GVHD); B-Cell Chronic LymphocyticLeukemia; Mycosis Fungoides; Sezary Syndrome Refractory ChronicLymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL);Multiple Sclerosis Alirocumab Proprotein Convertase Subtilisin/KexinType Heterozygous familial hypercholesterolemia (heFH); 9; ProproteinConvertase 9; Neural Apoptosis Hypercholesterolemia; Mixed DyslipidemiaFamilial Regulated Convertase 1; Subtilisin/Kexin LikeHypercholesterolemia (Type II Hyperlipoproteinemia); Protease PC9;PCSK9; EC 3.4.21. Hypercholesterolemia ALX-0061, Interleukin 6 Receptor;IL6R Rheumatoid Arthritis; Systemic Lupus Erythematosus vobarilizumabAmatuximab Mesothelin; CAKI Antigen; Pre Pro Malignant PleuralMesothelioma; Non-Small Cell Lung Cancer; Megakaryocyte PotentiatingFactor; MSLN Ovarian Cancer; Pancreatic Cancer Andecaliximab MMP9;matrix metallopeptidase 9 Gastroesophageal Junction Adenocarcinoma;Gastric Adenocarcinoma Anetumab, Mesothelin; CAKI Antigen; Pre Pro LungAdenocarcinoma; Malignant Pleural Mesothelioma Anetumab MegakaryocytePotentiating Factor; MSLN Advanced Malignancy; Solid Tumor Bile DuctCancer ravtansine (Cholangiocarcinoma); Breast Cancer; Colon Cancer;Endometrial Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer;Gastroesophageal (GE) Junction Carcinomas; Metastatic Pancreatic Cancer;Non-Small Cell Lung Cancer; Ovarian Cancer; Pancreatic Cancer;Peritoneal Cancer; Thymic Carcinoma; Uterine Cancer AnifrolumabInterferon Alpha/Beta Receptor 1; Cytokine Systemic Lupus; ErythematosusSystemic Sclerosis Receptor Class II Member 1; Cytokine (Scleroderma)Receptor Family 2 Member 1; Type I Interferon Receptor 1; IFNAR1Anrukinzumab, Interleukin 13; IL13 Asthma; Ulcerative Colitis IMA-638Apolizumab HLA-DR Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); AcuteLymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); ChronicLymphocytic Leukemia (CLL); Non-Hodgkin Lymphoma; Hematological CancersApomab Death receptor 5; DR5/TNF-related apoptosis Cancer inducingligand-receptor 2; TRAIL-R2. Aprutumab FGFR2 low blood neutrophils;Neutropenia; Febrile Neutropenia; Chemotherapy Induced Neutropenia;Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia) AquaporumabAquaporin-4; AQP4 Acute and Chronic Management of Neuromyelitis OpticaSpectrum Disorder Arcitumomab Carcinoembryonales Antigen; CEA DiagnosticImaging of Colorectal Cancers; Gastrointestinal Cancers (Diagnosis)Ascrinvacumab Serine/Threonine Protein Kinase Receptor Malignant PleuralMesothelioma; Metastatic Colorectal Cancer; R3; Activin Receptor LikeKinase 1; TGF B Transitional Cell Carcinoma (Urothelial Cell Carcinoma);Superfamily Receptor Type I; ALK1; ACVRL1; EC Hepatocellular Carcinoma2.7.11.30 Aselizumab L-Selectin; CD62L Chronic Lymphocytic Leukemia(CLL);; Chronic Obstructive Pulmonary Disease (COPD); Inflammatory BowelDisease; Vaso-Occlusive Crisis Associated With Sickle Cell DiseaseAtezolizumab Programmed Cell Death I Ligand 1; PD L1; B7 MetastaticTransitional (Urothelial) Tract Cancer; Non-Small Homolog 1; CD274 CellLung Cancer; Transitional Cell Carcinoma (Urothelial Cell Carcinoma)Bladder Cancer; Transitional Cell Carcinoma (Urothelial Cell Carcinoma)Epithelial Ovarian Cancer; Fallopian Tube Cancer; Metastatic BreastCancer; Metastatic Colorectal Cancer; Metastatic Hormone Refractory(Castration Resistant; androgen-Independent) Prostate Cancer; MetastaticMelanoma; Muscle Invasive Bladder Cancer (MIBC); Non-Small Cell LungCancer; Peritoneal Cancer; Renal Cell Carcinoma; Small-Cell Lung Cancer;Squamous Non-Small Cell Lung Cancer Bladder Cancer; Breast Cancer;Muscle Invasive Bladder Cancer (MIBC); Non-Small Cell Lung Carcinoma;Renal Cell Carcinoma; Small-Cell Lung Cancer; Transitional Cell Cancer(Urothelial Cell Cancer) Cervical Cancer; Diffuse Large B-Cell Lymphoma;Follicular Lymphoma; Metastatic Colorectal Cancer; Non Muscle InvasiveBladder Cancer (NMIBC) (Superficial Bladder Cancer); Non-Small Cell LungCancer; Soft Tissue Sarcoma; Solid Tumor; Uterine Cancer AcuteMyelocytic Leukemia (AML; Acute Myeloblastic Leukemia); AdenocarcinomaOf The Gastroesophageal Junction; Breast Cancer; Chronic LymphocyticLeukemia (CLL); Diffuse Large B- Cell Lymphoma; Esophageal Cancer;Follicular Lymphoma; Gastric Cancer; Hepatocellular Carcinoma; MalignantPleural Mesothelioma; Merkel Cell Carcinoma; Metastatic Melanoma;Metastatic Pancreatic Cancer; Multiple Myeloma (Kahler Disease);Myelodysplastic Syndrome; Nasopharyngeal Cancer; NeuroendocrineGastroenteropancreatic Tumors (GEP-NET); Refractory Acute MyeloidLeukemia; Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed AcuteMyeloid Leukemia; Relapsed Chronic Lymphocytic Leukemia (CLL) AtinumabReticulon 4; Human NogoA; Neurite Outgrowth Acute Spinal Cord InjuryInhibitor; Foocen; Neuroendocrine Specific Protein; NeuroendocrineSpecific Protein C Homolog; RTN x; Reticulon 5; RTN4 Atlizumab, IL6receptor rheumatoid arthritis; Crohn's disease; multiple myeloma andTocilizumab the lymphoproliferative disorder giant lymph nodehyperplasia (Castleman's disease). Aurograb Staphylococcus aureusMethicillin-Resistant Staphylococcus aureus (MRSA) Infections AvelumabProgrammed Cell Death 1 Ligand 1; PD L1; B7 Merkel Cell Carcinoma;Metastatic Transitional (Urothelial) Homolog 1; CD274 Tract Cancer;Bladder Cancer; Diffuse Large B-Cell Lymphoma; Epithelial OvarianCancer; Fallopian Tube Cancer; Gastric Cancer; Gastroesophageal (GE)Junction Carcinomas; Head and Neck Cancer Squamous Cell Carcinoma;Metastatic Renal Cell Carcinoma; Metastatic Transitional (Urothelial)Tract Cancer; Non-Small Cell Lung Cancer; Ovarian Cancer; PeritonealCancer Choriocarcinoma (Gestational Trophoblastic Neoplasia); EpithelialOvarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer; ThymicCarcinoma; Thymoma (Thymic Epithelial Tumor) Adenocarcinoma Of TheGastroesophageal Junction; Gastric Cancer Adrenocortical Carcinoma(Adrenal Cortex Cancer); Breast Cancer; Endometrial Cancer; FallopianTube Cancer; Glioblastoma Multiforme (GBM); Head and Neck CancerSquamous Cell Carcinoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma);Hormone Refractory (Castration Resistant; androgen-Independent) ProstateCancer; Malignant Mesothelioma; Melanoma; Metastatic Cancer; MetastaticColorectal Cancer; Nasopharyngeal Cancer; Osteosarcoma; PeritonealCancer; Renal Cell Carcinoma; Solid Tumor Leiomyosarcoma; Liposarcoma;Refractory Acute Myeloid Leukemia; Relapsed Acute Myeloid LeukemiaAzintuxizumab SLAMF7 Multiple Myeloma (Kahler Disease); RefractoryMultiple Myeloma; Relapsed Multiple Myeloma; B-Cell Chronic LymphocyticLeukemia Bapineuzumab Amyloid Beth Peptide; A beta P; Abeta; BetaAlzheimer's Disease Amyloid Basiliximab Interleukin 2 Receptor SubunitAlpha; TAC Inflammatory Bowel Disease; Ulcerative Colitis; Uveitis;Kidney Antigen; p55; CD25; IL2RA Transplant Rejection BavituximabPhosphatidylserine Hepatocellular Carcinoma Adenocarcinoma; RectalCancer Ebolavirus Infections (Ebola Hemorrhagic Fever); HemorrhagicFever; Unspecified Influenza Virus Infections Hepatitis C Melanoma;Metastatic Breast Cancer; Non-Small Cell Lung Cancer; Pancreatic CancerHormone Refractory (Castration Resistant; androgen-Independent) ProstateCancer; Non-Small Cell Lung Cancer Begelomab Dipeptidyl Peptidase 4;ADABP; Adenosine Graft Versus Host Disease (GVHD) Deaminase ComplexingProtein 2; T Cell Activation Antigen CD26; TP103; CD26; DPP4; EC3.4.14.5 Belimumab Tumor Necrosis Factor Ligand Superfamily SystemicLupus Erythematosus; Polymyositis/Idiopathic Member 13B; B LymphocyteStimulator; Inflammatory Myopathy; Microscopic Polyangiitis (MPA); Anti-Dendritic Cell Derived TNF Like Molecule; TNF Neutrophil CytoplasmicAntibody-Associated Vasculitis (ANCA and APOL Related LeukocyteExpressed Ligand Vasculitis); Granulomatosis with Polyangiitis (Wegener1; CD257; TNFSF13B Polyangiitis); Lupus Nephritis; MembranousGlomerulonephritis; Kidney Transplant Rejection; Myasthenia Gravis;Sicca Syndrome (Sjogren); Systemic Sclerosis (Scleroderma); IdiopathicThrombocytopenic Purpura (Immune Thrombocytopenic Purpura); RheumatoidArthritis Waldenstrom Macroglobulinemia Benralizumab Interleukin 5Receptor Subunit Alpha; IL 5 Asthma Chronic Obstructive PulmonaryDisease (COPD); Receptor Subunit Alpha; CDw125; CD125; IL5RARhinosinusitis; Hypereosinophilic Syndrome; Granulomatosis withPolyangiitis (Wegener Polyangiitis) Bertilimumab Eotaxin; C-C MotifChemokine II; Eosinophil Atopic Dermatitis; Bullous Pemphigoid; Crohn'sDisease Chemotactic Protein; Small Inducible Cytokine (RegionalEnteritis); Non-Alcoholic Steatohepatitis; Ulcerative All; CCLIIColitis; Atopic Keratoconjunctivitis; Vernal Keratoconjunctivitis; Wet(Neovascular/Exudative) Macular Degeneration; Primary SclerosingCholangitis; Psoriasis; Asthma; Betalutin Leukocyte Antigen CD37;Tetraspanin 26; Follicular Lymphoma; Mantle Cell Lymphoma; Marginal ZoneB- CD37 cell Lymphoma; Diffuse Large B-Cell Lymphoma Bevacizumab,Vascular endothelial growth factor; VEGF; Breast Cancer; CervicalCancer; Epithelial Ovarian Cancer; Bevacizumab VEGF-A Fallopian TubeCancer; Metastatic Ovarian Cancer; Metastatic beta, Renal CellCarcinoma; Peritoneal Cancer Colorectal Cancer; Bevacizumab- MetastaticBreast Cancer; Non-Small Cell Lung Cancer; Glioma; rhuMAb-VEGF, RenalCell Carcinoma Colorectal Cancer; Metastatic Breast Bevacituzuab Cancer;Non-Small Cell Lung Cancer; Metastatic Colorectal Cancer; OvarianCancer; Cervical Cancer; Epithelial Ovarian Cancer; Fallopian TubeCancer; Glioblastoma Multiforme (GBM); Metastatic Breast Cancer;Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma; Non-SmallCell Lung Cancer; Peritoneal Cancer; Breast Cancer; Cervical Cancer;Colorectal Cancer; Glioblastoma Multiforme (GBM); Malignant Glioma;Non-Small Cell Lung Cancer; Ovarian Cancer Lung Cancer; MetastaticColorectal Cancer; Cervical Cancer; Epithelial Ovarian Cancer; FallopianTube Cancer; Malignant Glioma; Metastatic Breast Cancer; MetastaticColorectal Cancer; Metastatic Renal Cell Carcinoma; Non-Small Cell LungCancer; Peritoneal Cancer; Cervical Cancer; Epithelial Ovarian Cancer;Fallopian Tube Cancer; Metastatic Colorectal Cancer; Peritoneal Cancer;Metastatic Breast Cancer; Metastatic Renal Cell Carcinoma; Non-SmallCell Lung Cancer; Ovarian Cancer; Metastatic Breast Cancer; MetastaticRenal Cell Carcinoma; Non-Small Cell Lung Cancer; Fallopian Tube Cancer;Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic RenalCell Carcinoma; Non-Small Cell Lung Cancer; Ovarian Cancer; PeritonealCancer; Glioma; Metastatic Breast Cancer; Non- Small Cell Lung Cancer;Cervical Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer;Metastatic Colorectal Cancer; Peritoneal Cancer; Cervical Cancer;Epithelial Ovarian Cancer; Fallopian Tube Cancer; Metastatic BreastCancer; Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma;Non- Small Cell Lung Cancer; Peritoneal Cancer; Glioblastoma Multiforme(GBM); Malignant Pleural Mesothelioma; Metastatic Breast Cancer; RenalCell Carcinoma; Neuroblastoma; Oligodendroglioma; Malignant PleuralMesothelioma; Merkel Cell Carcinoma; Nasopharyngeal Cancer; BladderCancer; Chronic Lymphocytic Leukemia (CLL); Diffuse Large B-CellLymphoma; Metastatic Liver Cancer; Non-Rhabdomyosarcoma;Rhabdomyosarcoma; Small-Cell Lung Cancer; Gastrointestinal Tumor;Meningioma; Metastatic Melanoma; Metastatic Pancreatic Cancer;Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Breast Cancer;Neuroendocrine Tumors; Non-Small Cell Lung Cancer; Cancer BezlotoxumabClostridium difficile Toxin B; toxB; EC 3.4.22. Clostridium difficileInfections (Clostridium difficile Associated Disease) Bimagrumab ActivinReceptor Type 2B; ACVR2B; EC Type 2 Diabetes; Bone Fracture; Sarcopenia;Cachexia; Cancer 2.7.11.30 Anorexia-Cachexia Syndrome; SporadicInclusion Body Myositis (s-IBM) Bimekizumab Interleukin 17A; Cytotoxic TLymphocyte Ulcerative Colitis; Plaque Psoriasis (Psoriasis Vulgaris);Associated Antigen 8; CTLA8; IL17A; Interleukin Rheumatoid Arthritis;Ankylosing Spondylitis (Bekhterev's 17F; Cytokine ML 1; IL17F Disease);Psoriatic Arthritis Bleselumab Tumor Necrosis Factor ReceptorSuperfamily Kidney Transplant Rejection; Plaque Psoriasis (PsoriasisMember 5; B Cell Surface Antigen CD40; Vulgaris) Bp50; CDw40; CD40LReceptor; TNFRSF5; CD40 Blinatumomab, B Lymphocyte Antigen CD19; BLymphocyte Acute Lymphocytic Leukemia (ALL; Acute LymphoblasticBlinatumumab Surface Antigen B4; Differentiation Antigen Leukemia);Extranodal Marginal Zone B-Cell Lymphoma CD19; T Cell Surface AntigenLau 12; CD19; T (Mucosa-Associated Lymphoid Tissue; MALT-Lymphoma); CellSurface Glycoprotein CD3 Epsilon Chain; Follicular Lymphoma; NodalMarginal Zone B-Cell Lymphoma; T Cell Surface Antigen T3/Leu 4 EpsilonChain; Splenic Marginal Zone B-Cell Lymphoma; Acute Lymphocytic CD3E;CD3 Leukemia (ALL; Acute Lymphoblastic Leukemia); Diffuse Large B-CellLymphoma; B-Cell Chronic Lymphocytic Leukemia; Hairy Cell Leukemia;Mantle Cell Lymphoma; Blontuvetmab Beth 2 Glycoprotein 1; APC Inhibitor;Activated Infectious Disease; Oncology Protein C Binding Protein;Anticardiolipin Cofactor; Apolipoprotein H; APOH; PhosphatidylserineBlosozumab Sclerostin; SOST Post Menopausal Osteoporosis BococizumabProprotein Convertase Subtilisin/Kexin Type Hyperlipidemia; Heterozygousfamilial hypercholesterolemia 9; Proprotein Convertase 9; NeuralApoptosis (heFH); Mixed Dyslipidemia; Atherosclerosis; Post AcuteRegulated Convertase 1; Subtilisin/Kexin Like Coronary Syndrome ProteasePC9; PCSK9; EC 3.4.21. Brazikumab Interleukin 23; IL23 Crohn's Disease(Regional Enteritis); Psoriasis Brentuximab, Tumor Necrosis FactorReceptor Superfamily Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); MycosisBrentuximab Member 8; CD30L Receptor; Ki 1 Antigen; Fungoides;Anaplastic Large Cell Lymphoma (ALCL); Cutaneous vedotin LymphocyteActivation Antigen CD30; CD30; T-Cell Lymphoma; Mycosis Fungoides;Hodgkin Lymphoma (B- TNFRSF8 Cell Hodgkin Lymphoma); T-Cell Lymphomas;Systemic Mastocytosis; Diffuse Large B-Cell Lymphoma; Mast CellLeukemia; Systemic Lupus Erythematosus; Acute Lymphocytic Leukemia (ALL;Acute Lymphoblastic Leukemia); Acute Myelocytic Leukemia (AML; AcuteMyeloblastic Leukemia); Anaplastic Large Cell Lymphoma (ALCL);Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy;Diffuse Large B-Cell Lymphoma; Hodgkin Lymphoma (B-Cell HodgkinLymphoma); Lymphoma; Mycosis Fungoides; Peripheral T-Cell Lymphomas(PTCL); Solid Tumor; T-Cell Leukemia; Malignant Mesothelioma; GraftVersus Host Disease (GVHD); Anaplastic Large Cell Lymphoma (ALCL);Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma) Briakinumab Interleukin 12Subunit Beta; Cytotoxic Multiple Sclerosis; Crohn's Disease (RegionalEnteritis); Plaque Lymphocyte Maturation Factor 40 kDa Psoriasis(Psoriasis Vulgaris) Subunit; CLMF p40; IL12 Subunit p40 NK CellStimulatory Factor Chain 2; IL12B Brodalumab Interleukin 17 Receptor;IL17R Plaque Psoriasis (Psoriasis Vulgaris); Psoriatic Arthritis; AxialSpondyloarthritis; Crohn's Disease (Regional Enteritis); RheumatoidArthritis; Asthma Brolucizumab Vascular Endothelial Growth Factor A;Diabetic Macular Edema; Wet (Neovascular/Exudative) VascularPermeability Factor; VEGFA Macular Degeneration; Keloids; Rosacea;Kaposi Sarcoma; Glioblastoma Multiforme (GBM) Brontictuzumab NeurogenicLocus Notch Homolog Protein 1; Adenoid Cystic Carcinoma (ACC); Bile DuctCancer Translocation Associated Notch Protein TAN 1;(Cholangiocarcinoma); Breast Cancer; Esophageal Cancer; NOTCH1 GastricCancer; Metastatic Colorectal Cancer; Pancreatic Cancer; Small-Cell LungCancer; Solid Tumor; Hematological Tumor BTT-ID23, Membrane PrimaryAmine Oxidase; Copper Primary Sclerosing Cholangitis; Inflammatory BowelDisease; Timolumab Amine Oxidase; Semicarbazide-Sensitive Neurology;Psoriasis; Rheumatoid Arthritis; Plaque Psoriasis Amine Oxidase;Vascular Adhesion Protein 1; (Psoriasis Vulgaris); Rheumatoid ArthritisHPAO; ADO3; EC 1.4.3.21 Burosumab Fibroblast Growth Factor 23;Phosphatonin; X-Linked Hypophosphatemic Rickets; Osteomalacia TumorDerived Hypophosphatemia Inducing Factor; FGF23 Cabiralizumab MacrophageColony Stimulating Factor 1 Pigmented Villonodular Synovitis;Tenosynovial Giant Cell Receptor; CSF 1 Receptor; Proto Oncogene cTumor; Glioblastoma Multiforme (GBM); Head and Neck Cancer Fms; CD115;CSFIR; EC 2.7.10.1 Squamous Cell Carcinoma; Melanoma; Non-Small CellLung Cancer; Ovarian Cancer; Pancreatic Cancer; Renal Cell Carcinoma;Colorectal Cancer; Rheumatoid Arthritis Camrelizumab PDCD1 Solid tumoursBreast cancer Melanoma Canakinumab Interleukin 1 Beta; IL 1 Beta;Catabolin; IL1B Cryopyrin-Associated Periodic Syndromes; Familial ColdAutoinflammatory Syndrome (Familial Cold Urticaria); Mevalonate KinaseDeficiency (Hyperimmunoglobulin D Syndrome (HIDS)); Muckle-WellsSyndrome; Tumor Necrosis Factor Receptor-Associated Periodic Syndrome(Familial Hibernian Fever); Systemic Idiopathic Juvenile Arthritis;Cryopyrin-Associated Periodic Syndromes; Familial Cold AutoinflammatorySyndrome (Familial Cold Urticaria); Muckle- Wells Syndrome; TumorNecrosis Factor Receptor-Associated Periodic Syndrome (FamilialHibernian Fever); Familial Mediterranean Fever; Familial ColdAutoinflammatory Syndrome (Familial Cold Urticaria); Muckle-WellsSyndrome; Neonatal Onset Multisystem Inflammatory Disease; SystemicIdiopathic Juvenile Arthritis; Cryopyrin-Associated Periodic Syndromes;Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria);Muckle-Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease;Cryopyrin- Associated Periodic Syndromes; Familial Cold AutoinflammatorySyndrome (Familial Cold Urticaria); Muckle- Wells Syndrome; NeonatalOnset Multisystem Inflammatory Disease; Cryopyrin-Associated PeriodicSyndromes; Familial Cold Autoinflammatory Syndrome (Familial ColdUrticaria); Muckle-Wells Syndrome; Neonatal Onset MultisystemInflammatory Disease; Cryopyrin-Associated Periodic Syndromes; FamilialCold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-WellsSyndrome; Gouty Arthritis (Gout); Cryopyrin-Associated PeriodicSyndromes; Familial Cold Autoinflammatory Syndrome (Familial ColdUrticaria); Muckle-Wells Syndrome; Neonatal Onset MultisystemInflammatory Disease; Cryopyrin-Associated Periodic Syndromes; FamilialCold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-WellsSyndrome Systemic Idiopathic Juvenile Arthritis; Mevalonate KinaseDeficiency (Hyperimmunoglobulin D Syndrome (HIDS)); Tumor NecrosisFactor Receptor-Associated Periodic Syndrome (Familial Hibernian Fever);Familial Mediterranean Fever; Systemic Idiopathic Juvenile Arthritis;Cardiovascular Risk Factors; Behcet Disease; Peripheral Arterial Disease(PAD)/ Peripheral Vascular Disease (PVD); Sarcoidosis; Pain; AbdominalAortic Aneurysms; Polymyalgia Rheumatica; Mucocutaneous Lymph NodeSyndrome (Kawasaki Disease); Choroidal Neovascularization;Keratoconjunctivitis sicca (Dry Eye); Chronic Obstructive PulmonaryDisease (COPD); Vasculitis; Rheumatoid Arthritis; Type I Diabetes(Juvenile Diabetes); Type 2 Diabetes; Gouty Arthritis (Gout) Cantuzumab,CanAg antigen; Mucin CanAg Colorectal Cancer; Gastric Cancer; Non-SmallCell Lung Cantuzumab Cancer; Pancreatic Cancer mertansine Cantuzumab,CanAg antigen; MUCI Colorectal Cancer; Gastric Cancer; Gastroesophageal(GE) Cantuzumab Junction Carcinomas; Non-Small Cell Lung Cancer;Pancreatic ravtansine Cancer; Solid Tumor Caplacizumab Von WillebrandFactor; VWF Thrombotic Thrombocytopenic Purpura; Acute Coronary SyndromeCarlumab C-C chemokine ligand 2 Inflammatory Bowel Disease; OvarianCancer; Solid Tumor; Metastatic Hormone Refractory (CastrationResistant; androgen-Independent) Prostate Cancer; Pancreatic Cancer;Idiopathic Pulmonary Fibrosis Catumaxomab CD3; Epithelial Cell AdhesionMolecule; Ascites; Adenocarcinoma Of The Gastroesophageal Junction;Adenocarcinoma Associated Antigen; Cell Peritoneal Cancer; EpithelialOvarian Cancer; Epithelial Tumor Surface Glycoprotein Trop 1; EpithelialCell Surface Antigen; Epithelial Glycoprotein 314; KS ¼ Antigen; KSA;Tumor Associated Calcium Signal Transducer 1; CD326; EPCAM Cergutuzumab,Interleukin 2 Receptor; IL2R Solid Tumor Cergutuzumab amunaleukinCertolizumab, Tumor Necrosis Factor; Cachectin; TNF Alpha; RheumatoidArthritis; Ankylosing Spondylitis (Bekhterev's Certolizumab TumorNecrosis Factor Ligand Superfamily Disease); Axial Spondyloarthritis;Psoriatic Arthritis; Plaque pegol Member 2; TNF a; TNF Psoriasis(Psoriasis Vulgaris); Crohn's Disease (Regional Enteritis) Cetuximab,Epidermal Growth Factor Receptor; Proto Head and Neck Cancer SquamousCell Carcinoma; Metastatic Erbitux Oncogene c ErbB 1; Receptor TyrosineProtein Colorectal Cancer; Recurrent Head and Neck Cancer Kinase erbB 1;HER1; ERBB1; EGFR; EC 2.7.10.1 Squamous Cell Carcinoma; MetastaticColorectal Cancer; Chronic Pain; Neuropathic Pain; Adenocarcinoma Of TheGastroesophageal Junction; Gastric Cancer; Metastatic Biliary TractCancer; Prostate Cancer; Fallopian Tube Cancer; Metastatic PancreaticCancer; Ovarian Cancer; Peritoneal Cancer; Non-Small Cell Lung Cancer;Pancreatic Cancer; Metastatic Breast Cancer; Non-Small Cell Lung Cancer;Squamous Cell Carcinoma Citatuzumab, Epithelial Cell Adhesion Molecule;Solid Tumor Citatuzumab Adenocarcinoma Associated Antigen; Cell bogatoxSurface Glycoprotein Trop 1; Epithelial Cell Surface Antigen; EpithelialGlycoprotein 314; KS ¼ Antigen; KSA; Tumor Associated Calcium SignalTransducer 1; CD326; EPCAM Cixutumumab Insulin Like Growth Factor 1Receptor; CD221; Carcinomas; Colon Cancer; Rectal Cancer; AdvancedIGFIR; EC 2.7.10.1 Malignancy; Ewing Sarcoma; Head and Neck CancerSquamous Cell Carcinoma; Hepatocellular Carcinoma; Islet Cell Carcinoma(Insulinoma); Leiomyosarcoma; Metastatic Breast Cancer; MetastaticColorectal Cancer; Metastatic Hepatocellular Carcinoma (HCC); MetastaticHormone Refractory (Castration Resistant; androgen-Independent) ProstateCancer; Metastatic Pancreatic Cancer; Neuroendocrine Tumors; Non-SmallCell Lung Cancer; Primitive Neuroectodermal Tumor (PNET);Rhabdomyosarcoma; Sarcomas; Soft Tissue Sarcoma Clazakizumab Interleukin6; B Cell Stimulatory Factor 2; Rheumatoid Arthritis; PsoriaticArthritis; Fatigue; Crohn's BSF2; CTL Differentiation Factor; CDF;Disease (Regional Enteritis); Oral Mucositis; Anemia; Graft HybridomaGrowth Factor; Interferon Beta 2; Versus Host Disease (GVHD); CancerAnorexia-Cachexia IFNB2; IL6 Syndrome Clivatuzumab, Mucin 1; BreastCarcinoma Associated Antigen Metastatic Pancreatic Cancer; PancreaticCancer Clivatuzumab DF3; Episialin; H23AG; Krebs Von Den Lungentetraxetan, 6; PEMT: Peanut Reactive Urinary Mucin; Yttrium (90Y)Polymorphic Epithelial Mucin; Tumor clivatuzumab Associated EpithelialMembrane Antigen; tetraxetan Tumor Associated Mucin; CD227; MUC1Codrituzumab Glypican 3; Heparan Sulphate Proteoglycan; MetastaticHepatocellular Carcinoma (HCC) Intestinal Protein DCI 5; GTR2 2; MXR7;GPC3 Coltuximab B Lymphocyte Antigen CD19; B Lymphocyte AcuteLymphocytic Leukemia (ALL; Acute Lymphoblastic ravtansine SurfaceAntigen B4; Differentiation Antigen Leukemia); Diffuse Large B-CellLymphoma CD19; T Cell Surface Antigen Leu 12; CD19 Conatumumab TumorNecrosis Factor Receptor Superfamily Colorectal Cancer; Lymphoma;Metastatic Cancer; Metastatic Member 10B; Death Receptor 5; TNF RelatedColorectal Cancer; Metastatic Pancreatic Cancer; Apoptosis InducingLigand Receptor 2; TRAIL Neuroendocrine Tumors; Non-Hodgkin Lymphoma;Non-Small Receptor 2; DRS; CD262; TNFRSF108 Cell Lung Cancer; Sarcomas;Soft Tissue Sarcoma; Solid Tumor; Non-Small Cell Lung Cancer; SolidTumor Concizumab Tissue Factor Pathway Inhibitor; Extrinsic HemophiliaA; Hemophilia B Pathway Inhibitor; EPI; Lipoprotein AssociatedCoagulation Inhibitor; LACI; TFPI Cosfroviximab Ebolavirus glycoproteinEbola virus infections Crenezumab Amylaid Beta Peptide; A beta P; Abate;Beta Alzheimer's Disease Amyloid Crizanlizumab P Selectin; CD62 AntigenLike Family Member Vaso-Occlusive Crisis Associated With Sickle CellDisease; P; Granule Membrane Protein 140; Leukocyte Sickle Cell DiseaseEndothelial Cell Adhesion Molecule 3; LECAM3; Platelet ActivationDependent Granule External Membrane Protein; CD62P; SELP CrotedumabGlucagon Receptor; GL R; GCGR Type 2 Diabetes Dacetuzumab Tumor NecrosisFactor Receptor Superfamily Multiple Myeloma (Kehler Disease); ChronicLymphocytic Member 5; B Cell Surface Antigen CD40; Leukemia (CLL);Diffuse Large B-Cell Lymphoma; B-Cell Non- Bp50; CDw40; CD40L Receptor;TNFRSF5; Hodgkin Lymphoma CD40 Dacliximab Interleukin 2 Receptor SubunitAlpha; TAC Relapsing Remitting Multiple Sclerosis (RRMS); UlcerativeAntigen; p55; CD25; IL2RA Colitis; Kidney Transplant RejectionDaclizumab Interleukin 2 Receptor Subunit Alpha; TAC Relapsing RemittingMultiple Sclerosis (RRMS); Ulcerative Antigen; p55; CD25; IL2RA Colitis;Kidney Transplant Rejection Dalotuzumab Insulin Like Growth Factor IReceptor; CD221; Metastatic Breast Cancer; Pancreatic Cancer; MetastaticIGFIR; EC 2.7.10.1 Colorectal Cancer; Multiple Myeloma (Kehler Disease);Neuroendocrine Tumors; Non-Small Cell Lung Cancer Dapirolizumab, CD40Ligand; T Cell Antigen Gp39; TNF Related Amyotrophic Lateral Sclerosis;Systemic Lupus Erythematosus Dapirolizumab Activation Protein; TumorNecrosis Factor pegal Ligand Superfamily Member 5; CD154; CD40LG; CD40LDaratumumab ADP Ribosyl Cyclase/Cyclic ADP Ribose Multiple Myeloma(Kehler Disease); Refractory Multiple Hydrolase 1; Cyclic ADP RiboseHydrolase 1; Myeloma; Amyloidosis; Diffuse Large B-Cell Lymphoma; T10;2′ Phospho ADP Ribosyl Cyclase/2′ Follicular Lymphoma; Mantle CellLymphoma; Myelodysplastic Phospho Cyclic ADP Ribose Transferase; ADPSyndrome; Non-Small Cell Lung Cancer; Multiple Myeloma Ribosyl Cyclase1; CD3B; EC 3.2.2.6; EC (Kehler Disease); Natural Killer Cell Lymphomas;Refractory 2.4.99.20 Acute Myeloid Leukemia; Relapsed Acute MyeloidLeukemia; T- Cell Lymphomas; Refractory Multiple Myeloma; RelapsedMultiple Myeloma; Acute Lymphocytic Leukemia (ALL; Acute LymphoblasticLeukemia); Chronic Lymphocytic Leukemia (CLL); Prostate CancerDectrekumab Interleukin 13; IL13; Lymphedema; Asthma; EosinophilicEsophagitis; Anal Fistula; Asthma; Idiopathic Pulmonary Fibrosis;Pulmonary Fibrosis; Seasonal Allergic Rhinitis Demcizumab Delta LikeProtein 4; Delta Like Ligand 4; Fallopian Tube Cancer; Non-Small CellLung Cancer; Ovarian Drosophila Delta Homolog 4; DLL4 Cancer; PancreaticDuctal Adenocarcinoma; Peritoneal Cancer; Metastatic Colorectal Cancer;Solid Tumor; Breast Cancer; Colon Cancer Denintuzumab, Expressing BLymphocyte Antigen CD19; B Burkitt Lymphoma; Acute Lymphocytic Leukemia(ALL; Acute Denintuzumab Lymphocyte Surface Antigen B4; LymphoblasticLeukemia); B-Cell Non-Hodgkin Lymphoma; mafodotin DifferentiationAntigen CD19; T Cell Surface Lymphoblastic Lymphoma; Mantle CellLymphoma; Follicular Antigen Leu 12; CD19 Lymphoma; Diffuse Large B-CellLymphoma Denosumab Tumor Necrosis Factor Ligand Superfamily HumoralHypercalcemia of Malignancy; Bone Metastasis; Giant Member II; ReceptorActivator Of Nuclear Cell Tumor Of Bone; Humoral Hypercalcemia ofMalignancy; Factor Kappa B Ligand; Osteoclast Osteoporosis; PostMenopausal Osteoporosis; Chemotherapy Differentiation Factor; TNFRelated Activation Effects; Rheumatoid Arthritis; OsteogenesisImperfecta; Bone Induced Cytokine; Osteoprotegerin Ligand; Disorders;Bone Metastasis; Glucocorticoid-Induced CD254; TNFSF11 Osteoporosis;Non-Small Cell Lung Cancer; Breast Cancer; Osteoarthritis; MetastaticBreast Cancer Depatuxizumab, Epidermal Growth Factor Receptor; ProtoGlioma; Colorectal Cancer; Glioblastoma Multiforme (GBM); DepatuxizumabOncogene c ErbB 1; Receptor Tyrosine Protein Head and Neck CancerSquamous Cell Carcinoma; Non-Small mafodotin Kinase erbB1; HER1; ERBB1;EGFR; EC 2.7.10.1 Cell Lung Cancer; Solid Tumor Derlotuximab, histonecomplex Glioma; Anaplastic Astrocytoma; Glioblastoma Multiforme Iodine(1311) (GBM) derlotuximab biotin Dezamizumab Serum Amyloid Protein; SAPAmyloidosis Dinutuximab Ganglioside GD2 Neuroblastoma; OsteosarcomaDinutuximabbeta Ganglioside GD2 Neuroblastoma Diridavumab HemagglutininInfluenza A Virus; H5N1 Subtype Infections; Pandemic InfluenzaDomagrozumab Growth/Differentiation Factor 8; Myostatin; DuchenneMuscular Dystrophy; Muscular Dystrophy; Becker GDF8; MSTN MuscularDystrophy Drozitumab, Tumor Necrosis Factor Receptor SuperfamilyNon-Small Cell Lung Cancer; Follicular Lymphoma; Colorectal DrozituabMember 10B; Death Receptor 5; TNF Related Cancer; Lymphoma; Non-HodgkinLymphoma; Apoptosis Inducing Ligand Receptor 2; TRAIL Chondrosarcoma;Metastatic Colorectal Cancer; Cancer Receptor 2; DR5; CD262; TNFRSF10BDuligotuzumab, Epidermal Growth Factor Receptor; Proto Non-Small CellLung Cancer; Epithelial Tumor; Metastatic Duligotumab Oncogene c ErbB 1;Receptor Tyrosine Protein Colorectal Cancer; Recurrent Head and NeckCancer; Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1; Squamous CellCarcinoma; Testicular Cancer Receptor Tyrosine Protein Kinase ERBB 3;Proto Oncogene Like Protein c ErbB 3; Tyrosine Kinase Type Cell SurfaceReceptor HER3; HER3; ERBB3; EC 2.7.10.1 Dupilumab Interleukin 4 ReceptorSubunit Alpha; CD124; Atopic Dermatitis; Nasal Polyposis; Sinusitis;Asthma; IL4R Eosinophilic Esophagitis; Food Allergy DurvalumabProgrammed Cell Death 1 Ligand 1; PD L1; B7 Bladder Cancer; MetastaticTransitional (Urothelial) Tract Homolog 1; CD274 Cancer; Head and NeckCancer Squamous Cell Carcinoma; Non-Small Cell Lung Cancer; RecurrentHead and Neck Cancer Squamous Cell Carcinoma; Acute Myelocytic Leukemia(AML; Acute Myeloblastic Leukemia); Adenocarcinoma Of TheGastroesophageal Junction; B-Cell Chronic Lymphocytic Leukemia; DiffuseLarge B-Cell Lymphoma; Esophageal Cancer; Follicular Lymphoma; GastricCancer; Germ Cell Tumors; Glioblastoma Multiforme (GBM); HepatocellularCarcinoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Lymphoma;Malignant Pleural Mesothelioma; Mantle Cell Lymphoma; Metastatic BreastCancer; Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma;Multiple Myeloma (Kahler Disease); Myelodysplastic Syndrome; OvarianCancer; Pancreatic Ductal Adenocarcinoma; Papillary Renal CellCarcinoma; Refractory Multiple Myeloma; Relapsed Multiple Myeloma;Small-Cell Lung Cancer; Ureter Cancer; Urethral Cancer; Urinary TractCancer; B-Cell Non-Hodgkin Lymphoma; Cervical Cancer; EndometrialCancer; Melanoma; Metastatic Biliary Tract Cancer; Multiple Myeloma(Kahler Disease); Muscle Invasive Bladder Cancer (MIBC); MyelodysplasticSyndrome; T-Cell Lymphomas Metastatic Hormone Refractory (CastrationResistant; androgen-Independent) Prostate Cancer; Mycosis Fungoides;Ovarian Cancer; Post-Essential Thrombocythemia Myelofibrosis (Post-ETMF); Post- Polycythemia Vera Myelofibrosis (PPV-MF); Sezary Syndrome;Soft Tissue Sarcoma; Non-Small Cell Lung Cancer; Advanced Malignancy;Solid Tumor; Muscle Invasive Bladder Cancer (MIBC) Dusigitumab InsulinLike Growth Factor I; Mechano Growth Hormone Sensitive Breast Cancer;Metastatic Breast Cancer; Factor; Somatomedin C; IGF1; Insulin LikeAdvanced Malignancy; Solid Tumor; Metastatic Hepatocellular GrowthFactor II; Somatomedin A; T3M II Carcinoma (HCC) Derived Growth Factor;IGF2 Duvortuxizumab B Lymphocyte Antigen CD19; B Lymphocyte FollicularLymphoma; B-Cell Chronic Lymphocytic Leukemia; (JNJ-B4052781) SurfaceAntigen B4; Differentiation Antigen Acute Lymphocytic Leukemia (ALL;Acute Lymphoblastic CD19; T Cell Surface Antigen Lou 12; CD19; CD3Leukemia); Diffuse Large B-Cell Lymphoma; Mantle Cell LymphomaEcromeximab Ganglioside GD3 Metastatic Melanoma Eculizumab, ComplementC5; C3 and PLP Like Alpha 2 Atypical Hemolytic Uremic Syndrome(Nondiarrhea- Erlizuab Macroglobulin Domain Containing Protein 4;Associated Hemolytic Uremic Syndrome); Paroxysmal C5 NocturnalHemoglobinuria; Myasthenia Gravis; Neuromyelitis Optica (Devic'sSyndrome); Membranoproliferative Glomerulonephritis (MesangiocapillaryGlomerulonephritis); Acquired (Autoimmune) Hemolytic Anemia;Membraneproliferative Glomerulonephritis Type II (Dense DepositDisease); Transplant Rejection; Vasculitis; Rheumatoid Arthritis;Dermatomyositis; Dry (Atrophic) Macular Degeneration; Allergic Asthma;Kidney Transplant Rejection; Typical Hemolytic Uremic Syndrome(Shiga-Toxin Associated Hemolytic Uremic Syndrome); Atypical HUSEfalizumab Integrin Alpha L; CDH Antigen Like Family Plaque Psoriasis(Psoriasis Vulgaris); Kidney Transplant Member A; Leukocyte AdhesionGlycoprotein Rejection; Rheumatoid Arthritis LFA 1Alpha Chain; CDIIa;ITGAL Efungumab Fungal Hsp90 Candida infection Eldelumab C—X—C MotifChemokine 10; 10 kDa Interferon Crohn's Disease (Regional Enteritis);Ulcerative Colitis; Gamma Induced Protein; Small Inducible RheumatoidArthritis Cytokine B10; Gamma IP10; CXCL10 Elezanumab Repulsive GuidanceMolecule-a; RGMA: Multiple Sclerosis Elgemtumab Receptor TyrosineProtein Kinase ERBB 3; Esophageal Cancer; Squamous Cell Carcinoma;Gastric Proto Oncogene Like Protein c ErbB 3; Cancer; Metastatic BreastCancer; Recurrent Head and Neck Tyrosine Kinase Type Cell SurfaceReceptor Cancer Squamous Cell Carcinoma HER3; HER3; ERBB3; EC 2.7.10.1Elotuzumab LOIXC Monoclonal antibodies Refractory Multiple Myeloma;Relapsed Multiple Myeloma; Multiple Myeloma (Kehler Disease) EmactuzumabMacrophage Colony Stimulating Factor 1 Pigmented Villonodular Synovitis;Bladder Cancer; Colorectal Receptor; CSF 1 Receptor; Proto Oncogene cCancer; Endometrial Cancer; Fallopian Tube Cancer; Gastric Fms; CD115;CSFIR; EC 2.7.10.1 Cancer; Malignant Mesothelioma; Melanoma; MetastaticBreast Cancer; Metastatic Ovarian Cancer; Pancreatic Cancer; Soft TissueSarcoma; Tenosynovial Giant Cell Tumor Emapalumab IFNG hemophagocyticlymphohistiocytosis (N1-0501) Emibetuzumab Hepatocyte Growth FactorReceptor; Proto Adenocarcinoma Of The Gastroesophageal Junction; GastricOncogene c Met; Tyrosine Protein Kinase Met; Cancer; MetastaticHepatocellular Carcinoma (HCC); HGF/SF Receptor; Scatter FactorReceptor; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer;MET; EC 2.7.10.1 Bone Metastasis; Lymphoma; Metastatic HormoneRefractory (Castration Resistant; androgen-Independent) Prostate Cancer;Metastatic Uveal Melanoma; Multiple Myeloma (Kehler Disease) EmicizumabCoagulation Factor IX; Christmas Factor; Hemophilia A PlasmaThromboplastin Component; F9; EC 3.4.21.22; Coagulation Factor X; StuartPrower Factor; Stuart Factor; F10; EC 3.4.21.6 Enavatuzumab TumorNecrosis Factor Receptor Superfamily Solid Tumor Member 12A; TWEAKReceptor; Fibroblast Growth Factor Inducible Immediate Early ResponseProtein 14; CD266; TNFRSF12A Enfortumab, Nectin 4; Ig SuperfamilyReceptor LNIR; Metastatic Transitional (Urothelial) Tract Cancer;Non-Small Enfortumab Poliovirus Receptor Related Protein 4; Nectin CellLung Cancer; Metastatic Breast Cancer; Solid Tumor vedotin Cell AdhesionMolecule 4; PVRL4; NECTIN4 Enlimomab, Intercellular Adhesion Molecule 1;Major Group Stroke Enlimomab pegol Rhinovirus Receptor; CD54; ICAM1Enoblituzumab CD276 Antigen; B7 Homolog 3; 4Ig B7 H3; Bladder Cancer;Breast Cancer; Childhood Costimulatory Molecule; CD276 Rhabdomyosarcoma;Colon Cancer; Ewing Sarcoma; Head and Neck Cancer; Head and Neck CancerSquamous Cell Carcinoma; Malignant Mesothelioma; Metastatic Melanoma;Metastatic Transitional (Urothelial) Tract Cancer; Neuroblastoma;Non-Small Cell Lung Cancer; Osteosarcoma; Ovarian Cancer; PancreaticCancer; Primitive Neuroectodermal Tumor (PNET); Prostate Cancer; RenalCell Carcinoma; Rhabdomyosarcoma; Soft Tissue Sarcoma; SquamousNon-Small Cell Lung Cancer; Thyroid Cancer; Wilms' Tumor(Nephroblastoma) Enokizumab Interleukin 9; Cytokine P40; T Cell GrowthAllergic Asthma Factor P40; IL9 Enoticumab Delta Like Protein 4; DeltaLike Ligand 4; Advanced Malignancy; Solid Tumor Drosophila Delta Homolog4; DLL4 Ensituximab Mucin 5AC; Gastric Mucin; Lewis B Blood MetastaticColorectal Cancer; Metastatic Pancreatic Cancer Group Antigen; MajorAirway Glycoprotein; Tracheobronchial Mucin; MUC5AC Entolimod Toll LikeReceptor 5; Toll/Interleukin 1 Adenoid Squamous Cell Carcinoma(Pseudoglandular Receptor Like Protein 3; TLR5 Squamous Cell Carcinoma);Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Liver Cancer;Uveal Melanoma; Radiation Toxicity (Radiation Sickness; Acute RadiationSyndrome); Colorectal Cancer Epratuzumab, B Cell Receptor CD22; BLymphocyte Cell Acute Lymphocytic Leukemia (ALL; Acute LymphoblasticYttrium (Y90) Adhesion Molecule; Sialic Acid Binding Ig Like Leukemia);Non-Hodgkin Lymphoma; Diffuse Large B-Cell epratuzumab Lectin 2; T CellSurface Antigen Lau 14; CD22 Lymphoma; Follicular Lymphoma; Waldenstromtetraxetan Macroglobulinemia; Sicca Syndrome (Sjogren); Systemic LupusErythematosus Eptacog beta Coagulation Factor VII; Proconvertin; SerumCongenital Hemophilia A; Congenital Hemophilia B; Hemophilia ProthrombinConversion Accelerator; SPCA; Eptacog Alfa; F7; EC 3.4.21.21 EptinezumabCalcitonin Gene Related Peptide; CGRP Migraine Erenumab Calcitonin GeneRelated Peptide Type I Migraine; Stable Angina; Vasomotor Symptoms ofMenopause Receptor; Calcitonin Receptor Like Receptor; (Hot Flashes)CALCRL Ertumaxomab Receptor Tyrosine Protein Kinase ERBB 2; Solid TumorMetastatic Lymph Node Gene 19 Protein; Proto Oncogene Neu; ProtoOncogene C ErbB 2; Tyrosine Kinase Type Cell Surface Receptor HER2;pI85erbB2; HER2; CD340; ERBB2; EC 2.7.10.1; T Cell Surface GlycoproteinCD3 Epsilon Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Chain; CD3EEtaracizumab Integrin Alpha V; Vitronectin Receptor Subunit ColorectalCancer; Metastatic Hormone Refractory Alpha; CD51; ITGAV; Integrin Beta3; Platelet (Castration Resistant; androgen-Independent) ProstateMembrane Glycoprotein IIIa; CD61; ITGB3 Cancer; Metastatic Melanoma;Psoriasis; Rheumatoid Arthritis Etrolizumab, Integrin Beta 7; Gut HomingReceptor Beta Hemophilia A; Hemophilia B; Crohn's Disease (RegionalEtrolizuab Subunit; ITGB7; integrin α7 β7 Enteritis); UlcerativeColitis; Inflammatory Bowel Disease Evinacumab Angiopoietin RelatedProtein 3; Angiopoietin 5; Homozygous Familial Hypercholesterolemia(HoFH); Angiopoietin Like Protein 3; ANG 5; ANGPTL3 HyperlipidemiaEvolocumab Proprotein Convertase Subtilisin/Kexin Type FamilialHypercholesterolemia (Type II Hyperlipoproteinemia); 9; ProproteinConvertase 9; Neural Apoptosis Hypercholesterolemia AtherosclerosisHeterozygous familial Regulated Convertase 1; Subtilisin/Kexin Likehypercholesterolemia (heFH); Homozygous Familial Protease PC9; PCSK9; EC3.4.21. Hypercholesterolemia (HoFH); Hypercholesterolemia ExbivirumabHepatitis B Virus Surface Antigen; HBsAg Hepatitis B Exenatide GlucagonLike Peptide 1 Receptor; GLPIR Obesity; Type 2 Diabetes FaralimomabInterferon Alpha/Beta Receptor 1; Cytokine Rheumatoid Arthritis;Systemic Lupus Erythematosus Receptor Class II Member 1; CytokineReceptor Family 2 Member 1; Type 1 Interferon Receptor 1; IFNAR1Farletuzumab Folate Receptor Alpha; Adult Folate Binding LungAdenocarcinoma; Ovarian Cancer; Pituitary Tumor Protein; Folate Receptor1; KB Cells FBP; Ovarian Tumor Associated Antigen MDv18; FOLR1 FasinumabBeta Nerve Growth Factor; Beta NGF; NGF Low Back Pain; OsteoarthritisPain; Chronic Pancreatitis Pain; Sciatic Pain; Vertebral Fracture PainFerritizumab Ferritin Non-Small Cell Lung Cancer; Pancreatic CancerFezakinumab Interleukin 22; Cytokine Zcyto18; IL 10 Related Psoriasis;Rheumatoid Arthritis T Cell Derived Inducible Factor; IL22 FG-3019,Connective Tissue Growth Factor; CCN Family Duchenne Muscular Dystrophy;Pancreatic Ductal Pamrevlumab Member 2; Hypertrophic ChondrocyteAdenocarcinoma; Idiopathic Pulmonary Fibrosis; Liver Fibrosis; SpecificProtein 24; Insulin Like Growth Focal Segmental Glomerulosclerosis(FSGS); Microalbuminuria; Factor Binding Protein 8; IGFBP8; CTGFProteinuria; Systemic Sclerosis (Scleroderma); Diabetic Nephropathy;Type 1 Diabetes (Juvenile Diabetes); Type 2 Diabetes Fibatuzumab EPHA3;ephrin receptor A3 Glioblastoma Multiforme (GBM); Solid Tumor;Myelofibrosis; Myelodysplastic Syndrome; Multiple Myeloma (KehlerDisease); Acute Lymphocytic Leukemia (ALL; Acute LymphoblasticLeukemia); Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia);Chronic Lymphocytic Leukemia (CLL); Chronic Myelocytic Leukemia (CML;Chronic Myeloid Leukemia); Myeloproliferative Disorders FiclatuzumabHepatocyte Growth Factor Receptor; Proto Nasopharyngeal Cancer;Recurrent Head and Neck Cancer Oncogene c Met; Tyrosine Protein KinaseMet; Squamous Cell Carcinoma; Refractory Acute Myeloid Leukemia; HGF/SFReceptor; Scatter Factor Receptor; Relapsed Acute Myeloid Leukemia;Esophageal Cancer; Gastric MET; EC 2.7.10.1 Cancer; Head and Neck CancerSquamous Cell Carcinoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma);Hypopharyngeal Cancer; Laryngeal Cancer; Metastatic Breast Cancer;Metastatic Colorectal Cancer; Metastatic Pancreatic Cancer; MultipleMyeloma (Kehler Disease); Non-Hodgkin Lymphoma; Oral Cavity (Mouth)Cancer; Oropharyngeal Cancer; Non-Small Cell Lung Cancer FigitumumabInsulin Like Growth Factor 1 Receptor; CD221; Adenocarcinoma; BreastCancer; Colon Cancer; Multiple IGFIR; EC 2.7.10.1 Myeloma (KehlerDisease); Rectal Cancer; Breast Cancer; Ewing Sarcoma; GastrointestinalTract Cancer; Hormone- Sensitive Prostate Cancer; Non-Small Cell LungCancer; Small- Cell Lung Cancer; Urinary Tract Cancer FirivumabHemagglutinin Unspecified Influenza Virus Infections Flanvotumab 5,6Dihydroxyindole 2 Carboxylic Acid Melanoma Oxidase; Glycoprotein 75;Melanoma Antigen gp75; Tyrosinase Related Protein 1; Catalase B; TYRP1;EC 1.14.18. Fletikumab Interleukin 20; Cytokine Zcyto10; IL20 Psoriasis;Rheumatoid Arthritis Fontolizumab Interferon Gamma; Immune Interferon;IFNG Colitis; Crohn's Disease (Regional Enteritis); Rheumatoid ArthritisForalumab T Cell Surface Glycoprotein CD3 Epsilon Crohn's Disease(Regional Enteritis); Autoimmune Disorders; Chain; T Cell SurfaceAntigen T3/Leu 4 Epsilon Kidney Transplant Rejection; Inflammatory BowelDisease; Chain; CD3E Non-Alcoholic Steatohepatitis; Type 1 Diabetes(Juvenile Diabetes) Foravirumab Rabies Virus Glycoprotein RabiesFremanezumab Calcitonin Gene Related Peptide; CGRP Cluster HeadacheSyndrome; Migraine; Vasomotor Symptoms of Menopause (Hot Flashes)Fresolimumab Transforming Growth Factor Beta 1; TGFB1; Non-Small CellLung Cancer; Osteogenesis Imperfecta; Glioma; Transforming Growth FactorBeta 2; BSC1Cell Melanoma; Renal Cell Carcinoma; Solid Tumor; IdiopathicGrowth Inhibitor; Cetermin; Glioblastoma Pulmonary Fibrosis; FocalSegmental Glomerulosclerosis Derived T Cell Suppressor Factor;Polyergin; (FSGS) TGFB2; Transforming Growth Factor Beta 3; TGFB3Frunevetmab Mus musculus nerve growth factor; Felis Control ofOsteoarthritis Pain in Cats catus-Rattus norvegicus monoclonal NV-02heavy chain; disulfide with Felis catus-Rattus norvegicus monoclonalNV-02 light chain; dimer Fulranumab Beta Nerve Growth Factor; Beta NGF;NGF Pain; Chronic Visceral Pain; Diabetic Neuropathic Pain; Low BackPain; Postherpetic Neuralgia; Interstitial Cystitis (Painful BladderSyndrome); Cancer Pain; Osteoarthritis Pain Futuximab Epidermal GrowthFactor Receptor; Proto Glioblastoma Multiforme (GBM); MetastaticColorectal Cancer; Oncogene c ErbB1; Receptor Tyrosine Protein RecurrentHead and Neck Cancer Squamous Cell Carcinoma; Kinase erbB1; HER1; ERBB1;EGFR; EC 2.7.10.1 Squamous Non-Small Cell Lung Cancer; EsophagealCancer; Solid Tumor Galcanezumab Calcitonin Gene Related Peptide; CGRPCluster Headache Syndrome; Migraine; Osteoarthritis Pain Galiximab, TLymphocyte Activation Antigen CD80; Autoimmune Disorders; Inflammation;Psoriasis; Rheumatoid Goilixiab Activation B7-1 Antigen; CTLA 4 CounterArthritis; Follicular Lymphoma; B-cell Lymphoma Receptor B7.1; CD80Ganitumab Insulin Like Growth Factor 1 Receptor; CD221; Breast Cancer;Neuroendocrine Tumors; Ovarian Cancer; IGFIR; EC 2.7.10.1 Ewing Sarcoma;Metastatic Breast Cancer; Metastatic Colorectal Cancer; Non-HodgkinLymphoma; Small-Cell Lung Cancer; Soft Tissue Sarcoma; SquamousNon-Small Cell Lung Cancer; Metastatic Adenocarcinoma of The Pancreas;Metastatic Pancreatic Cancer Gantenerumab Amyloid Beta Peptide; A betaP; Abeta; Beta Alzheimer's Disease Amyloid Gatipotuzumab Homo sapiensMUC1; mucin 1; polymorphic epithelial mucin; PEM; episialin; CD227 tumorantigen TA-MUC1 conformational epitope O- glycosylated on the threonineof the immunodominant PDTRP motif of the tandem repeats GavilimomabBasigin; Collagenase Stimulatory Factor; Graft Versus Host Disease(GVHD) Extracellular Matrix Metalloproteinase Inducer; LeukocyteActivation Antigen MG; OK Blood Group Antigen; Tumor Cell DerivedCollagenase Stimulatory Factor; CD147; BSG Gedivumab Influenza A virushemagglutinin HA Influenza disease; Gemetuzumab, Myeloid Cell SurfaceAntigen CD33; Sialic Acid Acute Myelocytic Leukemia (AML) GemtuzumabBinding Ig Like Lectin 3; gp67; CD33 ozogamicin, Gemtuzumab GerilimzumabInterleukin 6; B Cell Stimulatory Factor 2; Autoimmune Disorders;Inflammation; Rheumatoid Arthritis BSF2; CTL Differentiation Factor;CDF; Hybridoma Growth Factor; Interferon Beta 2; IFNB2; IL6 GevokizumabInterleukin 1 Beta; IL 1 Beta; Catabolin; IL1B Acute Coronary Syndrome;Behcet Disease; Giant Cell Arteritis; Schnitzler Syndrome;Dermatomyositis; Polymyositis; Uveitis; Behcet Disease; Acne Vulgaris;Skin Inflammation; Autoimmune Disorders; Rheumatoid Arthritis; DiabeticNephropathy; Type 2 Diabetes; Type 1 Diabetes (Juvenile Diabetes); GoutyArthritis (Gout); Osteoarthritis; Systemic Idiopathic JuvenileArthritis; Multiple Myeloma (Kehler Disease); Anterior Uveitis;Intermediate Uveitis; Posterior Uveitis; Uveitis; Scleritis GilvetmabCanis familiaris PDCD1 Antineoplastic; Immunotherapy (Veterinary)Gimsilumab Granulocyte Macrophage Colony Stimulating RheumatoidArthritis Factor; GMCSF; Colony Stimulating Factor; CSF; Molgramostin;Sargramostim; CSF2 Girentuximab, Carbonic Anhydrase 9; Carbonate RenalCell Carcinoma Iodine (1241) Dehydratase IX; pMW1; Membrane Antigen MN;girentuximab P54/58N; Renal Cell Carcinoma Associated Antigen G250; CA9;EC 4.2.1.1; CA-IX Glembatumumab Transmembrane Glycoprotein NMB; LungCancer; Osteosarcoma; Metastatic Uveal Melanoma; vedotin TransmembraneGlycoprotein HGFIN; GPNMB Metastatic Breast Cancer; Metastatic Melanoma;Squamous Non-Small Cell Lung Cancer Glunomab Glutamate ReceptorIonotropic NMDA 1; Multiple Sclerosis Glutamate [NMDA] Receptor SubunitZeta 1; N Methyl D Aspartate Receptor Subunit NR1; GRIN1 Golimumab TumorNecrosis Factor; Cachectin; TNF Alpha; Ulcerative Colitis; AnkylosingSpondylitis (Bekhterev's Tumor Necrosis Factor Ligand SuperfamilyDisease); Axial Spondyloarthritis; Psoriatic Arthritis; Member 2; TNF a;TNF Rheumatoid Arthritis; Ankylosing Spondylitis (Bekhterev's Disease);Psoriatic Arthritis; Systemic Idiopathic Juvenile Arthritis; Type 1Diabetes (Juvenile Diabetes); Sarcoidosis; Systemic Idiopathic JuvenileArthritis; Anterior Uveitis; Posterior Uveitis; Asthma GuselkumabInterleukin 23 Subunit Alpha; Interleukin 23 Plaque Psoriasis (PsoriasisVulgaris); Psoriatic Arthritis; Subunit p19; IL23A Rheumatoid ArthritisHuMab IDF8 IL8 Inflammatory bowel disease and asthma HuMab LC5002-Interleukin 13 Asthma; Atopic Dermatitis; Idiopathic Pulmonary Fibrosis;002 Pulmonary Fibrosis; Seasonal Allergic Rhinitis; Lymphedema;Ulcerative Colitis; Systemic Sclerosis (Scleroderma); Allergies HuMabLC5002- Interleukin 13 Asthma; Atopic Dermatitis; Idiopathic PulmonaryFibrosis; 003 Pulmonary Fibrosis; Seasonal Allergic Rhinitis;Lymphedema; Ulcerative Colitis; Systemic Sclerosis (Scleroderma);Allergies HuMab LC5002- Interleukin 13 Asthma; Atopic Dermatitis;Idiopathic Pulmonary Fibrosis; 005 Pulmonary Fibrosis; Seasonal AllergicRhinitis; Lymphedema; Ulcerative Colitis; Systemic Sclerosis(Scleroderma); Allergies HuMab LC5002- Interleukin 13 Asthma; AtopicDermatitis; Idiopathic Pulmonary Fibrosis; 007 Pulmonary Fibrosis;Seasonal Allergic Rhinitis; Lymphedema; Ulcerative Colitis; SystemicSclerosis (Scleroderma); Allergies HuMab LC5002- Interleukin 13 Asthma;Atopic Dermatitis; Idiopathic Pulmonary Fibrosis; 018 PulmonaryFibrosis; Seasonal Allergic Rhinitis; Lymphedema; Ulcerative Colitis;Systemic Sclerosis (Scleroderma); Allergies HuMab-708 CD20 Diseasesassociated with CD20 (including tumor-related diseases) and immunediseases (including autoimmune diseases) huMAb-anti- merozoite surfaceprotein 10; MSP-10 Malaria; Plasmodium associate Diseases MSP10.1huMAb-anti- merozoite surface protein 10; MSP-10 Malaria; Plasmodiumassociate Diseases MSP10.2 HuMab-L612 Ganglioside GM3 metastaticmelanoma Ibalizumab T Cell Surface Glycoprotein CD4; T Cell HumanImmunodeficiency Virus (HIV) Infections (AIDS) Surface Antigen T4/Leu 3;CD4 Ibritumomab, B Lymphocyte Antigen CD20; B Lymphocyte AcuteLymphocytic Leukemia (ALL); Acute Myelocytic Leukemia IbritumomabSurface Antigen B1; Bp35; Leukocyte Surface (AML); Chronic LymphocyticLeukemia (CLL); Chronic tiuxetan Antigen Leu 16; Membrane Spanning 4Myelocytic Leukemia (CML); Multiple Myeloma (Kahler Disease); DomainsSubfamily A Member 1; CD20; MS4A1 Myeloproliferative Disorders;Colorectal Cancer; Gastric Cancer; Melanoma; Prostate Cancer;Myelodysplastic Syndrome; Myelofibrosis; Glioblastoma Multiforme (GBM);Solid Tumor; non-Hodgkin's Lymphoma Icrucumab Vascular EndothelialGrowth Factor Receptor Metastatic Breast Cancer; Metastatic ColorectalCancer; 1; Fms Like Tyrosine Kinase 1; Tyrosine Protein TransitionalCell Carcinoma (Urothelial Cell Carcinoma) Kinase Receptor FLT; TyrosineProtein Kinase FRT; Vascular Permeability Factor Receptor; VEGFR1; FLT1;EC 2.7.10.1 Idarucizumab Dabigatran; Pradaxa ® Bleeding and ClottingDisorders Ifabotuzumab CD22 Acute Lymphocytic Leukemia (ALL; AcuteLymphoblastic Leukemia); Acute Myelocytic Leukemia (AML; AcuteMyeloblastic Leukemia); Chronic Lymphocytic Leukemia (CLL); ChronicMyelocytic Leukemia (CML; Chronic Myeloid Leukemia); Multiple Myeloma(Kahler Disease); Myeloproliferative Disorders; Colorectal Cancer;Gastric Cancer; Melanoma; Prostate Cancer; Myelodysplastic Syndrome;Myelofibrosis; Glioblastoma Multiforme (GBM); Solid Tumor IGF-IRHUMAB-1A Soluble extracellular domain of IGF-IR. Tumor; Cancer IGF-IRHUMAB- Soluble extracellular domain of IGF-IR. Tumor; Cancer 23 IGF-IRHUMAB-8 Soluble extracellular domain of IGF-IR. Tumor; Cancer ImAb1IDH1R132H Glioma Imalumab Macrophage Migration Inhibitory Factor;Metastatic Colorectal Cancer; Solid Tumor; Septic Shock; GlycosylationInhibiting Factor; L Dopachrome Multiple Sclerosis; Colitis;Glomerulonephritis; Lupus Nephritis; Isomerase; L DopachromeTautomerase; Diabetes; Arthritis; Malignant Ascites PhenylpyruyateTautomerase; MIF; EC 5.3.2.1; EC 5.3.3.12 Imgatuzumab Epidermal GrowthFactor Receptor; Proto Head and Neck Cancer Squamous Cell Carcinoma;Metastatic Oncogene c ErbB 1; Receptor Tyrosine Protein ColorectalCancer; Non-Small Cell Lung Cancer; Solid Tumor Kinase erbB 1; HER1;ERBB1; EGFR; EC 2.7.10.1 Inclacumab P Selectin; CD62 Antigen Like FamilyMember Peripheral Arterial Disease (PAD)/ Peripheral Vascular P; GranuleMembrane Protein 140: Leukocyte Disease (PVD); Acute Coronary Syndrome;Myocardial Endothelial Cell Adhesion Molecule 3; LECAM3; Infarction;Percutaneous Coronary Intervention Platelet Activation Dependent GranuleExternal Membrane Protein; CD62P; SELP Inhibitor Indatuximab, SyndecanI; CD138; SDC1 Lung Cancer; Prostate Cancer; Head and Neck Cancer;Indatuximab Pancreatic Cancer; Breast Cancer; Bladder Cancer; ravtansineRefractory Multiple Myeloma; Relapsed Multiple Myeloma Indusatumab, HeatStable Enterotoxin Receptor; Guanylyl Metastatic Colorectal Cancer;Adenocarcinoma Of The Indusatumab Cyclase C; or Intestinal GuanylateCyclase; Gastroesophageal Junction; Gastric Cancer; Adenocarcinomavedotin GUCY2C; EC 4.6.1.2 Of The Gastroesophageal Junction; GastricCancer; Metastatic Adenocarcinoma of The Pancreas Inebilizumab CentralNervous System Progressive Relapsing Multiple Sclerosis (PRMS);Relapsing Remitting Multiple Sclerosis (RRMS); Secondary ProgressiveMultiple Sclerosis (SPMS); Neuromyelitis Optica (Devic's Syndrome);Follicular Lymphoma; Mantle Cell Lymphoma; Non- Hodgkin Lymphoma;Follicular Lymphoma; Refractory Multiple Myeloma; Relapsed MultipleMyeloma; Multiple Myeloma (Kahler Disease); Systemic Sclerosis(Scleroderma); Diffuse Large B- Cell Lymphoma; Refractory ChronicLymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL)Infliximab Tumor Necrosis Factor; Cachectin; TNF Alpha; Crohn's Disease(Regional Enteritis); Ulcerative Colitis Plaque Tumor Necrosis FactorLigand Superfamily Psoriasis (Psoriasis Vulgaris); Psoriasis; RheumatoidArthritis Member 2; TNF a; TNF; TNFa Ankylosing Spondylitis (Bekhterev'sDisease); Psoriatic Arthritis Behcet Disease Crohn's Disease (RegionalEnteritis); Ulcerative Colitis Mucocutaneous Lymph Node Syndrome(Kawasaki Disease); Plaque Psoriasis (Psoriasis Vulgaris); Psoriasis;Rheumatoid Arthritis Giant Cell Arteritis Juvenile Rheumatoid Arthritis;Sarcoidosis Cancer Anorexia-Cachexia Syndrome Hepatitis C; AutoimmuneDisease Inolimomab Interleukin 2 Receptor Subunit Alpha; TAC GraftVersus Host Disease (GVHD) Antigen; p55; CD25; IL2RA Insulin peglisproInsulin Receptor; IR; CD220; INSR; EC 2.7.10.1 Type 1 Diabetes (JuvenileDiabetes); Type 2 Diabetes Interferon beta- Interferon Alpha/BetaReceptor 1; Cytokine Alopecia; Demyelinating Diseases; MultipleSclerosis; Relapsing 1b Receptor Class II Member 1; Cytokine RemittingMultiple Sclerosis (RRMS); Secondary Progressive Receptor Family 2Member 1; Type I Interferon Multiple Sclerosis (SPMS) Receptor 1;IFNAR1; Interferon Alpha/Beta Receptor 2; Interferon Alpha BindingProtein; Type I Interferon Receptor 2; IFNAR2 Intetumumab Integrin AlphaV; Vitronectin Receptor Subunit Angiosarcoma; Hormone Refractory(Castration Resistant; Alpha; CD51; ITGAV; Integrin Beta 1; Fibronectinandrogen-Independent) Prostate Cancer; Metastatic Receptor Subunit Beta;Glycoprotein lia; VLA 4 Melanoma; Melanoma Subunit Beta; CD29; ITGB1;Integrin Beta 3; Platelet Membrane Glycoprotein IIIa; CD61; ITGB3;Integrin Beta 5; ITGB5; Integrin Beta 6; ITGB6 Ipilimumab Cytotoxic TLymphocyte Protein 4; Cytotoxic T Metastatic Melanoma; Head and NeckCancer Squamous Cell Lymphocyte Associated Antigen 4; CD152; Carcinoma;Metastatic Renal Cell Carcinoma; Non-Small Cell CTLA4 Lung CancerAdenocarcinoma Of The Gastroesophageal Junction; Adrenal Gland Cancer;Gastric Cancer; Metastatic Liver Cancer; Metastatic Lung Cancer; OvarianCancer; Skin Cancer Chronic Myelocytic Leukemia (CML; Chronic MyeloidLeukemia); Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Non-HodgkinLymphoma; Refractory Multiple Myeloma; Relapsed Multiple MyelomaAdenocarcinoma; Breast Cancer; Metastatic Adenocarcinoma of ThePancreas; Transitional Cell Cancer (Urothelial Cell Cancer); MetastaticHormone Refractory (Castration Resistant; androgen-Independent);Prostate Cancer Iratumumab Tumor Necrosis Factor Receptor SuperfamilyAnaplastic Large Cell Lymphoma (ALCL); Hodgkin Lymphoma Member 8; CD30LReceptor; Ki 1 Antigen; (B-Cell Hodgkin Lymphoma) Lymphocyte ActivationAntigen CD30; CD30; TNFRSF8 Isatuximab ADP Ribosyl Cyclase/Cyclic ADPRibose Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Hydrolase1; Cyclic ADP Ribose Hydrolase 1; Multiple Myeloma (Kahler Disease);Acute Lymphocytic T10; 2′ Phospho ADP Ribosyl Cyclase/2′ Leukemia (ALL;Acute Lymphoblastic Leukemia); Acute Phospho Cyclic ADP RiboseTransferase; ADP Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia);B- Ribosyl Cyclase 1; CD38; EC 3.2.2.6; EC Cell Non-Hodgkin Lymphoma;Chronic Lymphocytic Leukemia 2.4.99.20 (CLL) Itolizumab T CellDifferentiation Antigen CD6; T12; TP120; Plaque Psoriasis (PsoriasisVulgaris); Arthritis; Relapsing CD6 Remitting Multiple Sclerosis (RRMS);Rheumatoid Arthritis; Vitiligo; Psoriatic Arthritis IxekizumabInterleukin 17A; Cytotoxic T Lymphocyte Ankylosing Spondylitis(Bekhterev's Disease); Rheumatoid Associated Antigen 8; CTLA8; IL17AArthritis; Plaque Psoriasis (Psoriasis Vulgaris); Psoriatic Arthritis;Axial Spondyloarthritis Labetuzumab, Carcinoembryonic Antigen RelatedCell Ovarian Cancer; Small-Cell Lung Cancer; Metastatic ColorectalLabetuzumab Adhesion Molecule 5; Carcinoembryonic Cancer; ColorectalCancer govitecan Antigen; CEA; Meconium Antigen 100; CD66e; CEACAM5Lacnotuzumab Macrophage Colony Stimulating Factor 1 PigmentedVillonodular Synovitis; Tenosynovial Giant Cell Receptor; CSF 1Receptor; Proto Oncogene c Tumor; Glioblastoma Multiforme (GBM); Headand Neck Cancer Fms; CD115; CSF1R; EC 2.7.10.1 Squamous Cell Carcinoma;Melanoma; Non-Small Cell Lung Cancer; Ovarian Cancer; Pancreatic Cancer;Renal Cell Carcinoma; Colorectal Cancer; Rheumatoid ArthritisLampalizumab Complement Factor D; C3 Convertase Dry (Atrophic) MacularDegeneration Activator; Adipsin; Properdin Factor D; CFD; EC 3.4.21.46Lanadelumab Kallikrein; EC 3.4.21. Diabetic Macular Edema; HereditaryAngioedema (HAE) (C1 Esterase Inhibitor [C1-INH] Deficiency)Landogrozumab Growth/Differentiation Factor 8; Myostatin; CancerAnorexia-Cachexia Syndrome; Muscle Atrophy GDF8; MSTN Laprituximab,EGFR; epidermal growth factor receptor Laprituximab emtansineLarcaviximab Ebolavirus glycoprotein Ebola virus infections LebrikizumabInterleukin 13; IL13 Idiopathic Pulmonary Fibrosis; Atopic Dermatitis;Chronic Obstructive Pulmonary Disease (COPD); Idiopathic PulmonaryFibrosis; Asthma Lendalizumab Complement 5; Anaphylatoxine; C5a; C5Pr678-751];. Lenercept Tumor Necrosis Factor Receptor Superfamily SepticShock; Multiple Sclerosis; Rheumatoid Arthritis; Sepsis; Member 1A;Tumor Necrosis Factor Receptor 1; Tumor Necrosis Factor Receptor Type I;p55; p60; CD120a; TNFRSF1A Lenzilumab Granulocyte Macrophage ColonyStimulating Leukemias Multiple Sclerosis Psoriasis Bone Cancer; JuvenileFactor; GMCSF; Colony Stimulating Factor; Myelomonocytic Leukemia (JMML)Chronic Obstructive CSF; Molgramostin; Sargramostim; CSF2 PulmonaryDisease (COPD) Rheumatoid Arthritis Asthma Lerdelimumab TransformingGrowth Factor Beta 2; BSC1 Cell Glaucoma Drainage Surgery GrowthInhibitor; Cetermin; Glioblastoma Derived T Cell Suppressor Factor;Polyergin; TGFB2 Lesofavumab Influenza B virus hemagglutinin HAInfectious Disease Letolizumab CD40 Ligand; T Cell Antigen Gp39; TNFRelated Idiopathic Thrombocytopenic Purpura (Immune Activation Protein;Tumor Necrosis Factor Thrombocytopenic Purpura) Ligand SuperfamilyMember 5; CD154; CD40LG Lexatumumab Tumor Necrosis Factor ReceptorSuperfamily Solid Tumor Member 10B; Death Receptor 5; TNF RelatedApoptosis Inducing Ligand Receptor 2; TRAIL Receptor 2; DR5; CD262;TNFRSF10B Libivirumab Hepatitis B Virus Surface Antigen; HBsAg HepatitisB Lifastuzumab, Sodium Dependent Phosphate Transport Non-Small Cell LungCancer; Ovarian Cancer Lifastuzumab Protein 2B; Sodium PhosphateTransport vedotin Protein 2B; NaPi3b; Sodium/Phosphate Cotransporter 2B;NaPi 2b; Solute Carrier Family 34 Member 2; SLC34A2; phosphate- sodiumco-transporter Ligelizumab Immunoglobulin E; IgE Allergic Asthma;Chronic Urticaria; Hives; Atopic Dermatitis; Bullous PemphigoidLilotomab, Leukocyte Antigen CD37; Tetraspanin 26; Diffuse Large B-CellLymphoma; Follicular Lymphoma; Mantle Betalutin, CD37 Cell Lymphoma;Marginal Zone B-cell Lymphoma Lutetium (I77Lu) Lilotomab satetraxetanLintuzumab, Myeloid Cell Surface Antigen CD33; Sialic Acid RefractoryAcute Myeloid Leukemia; Acute Myelocytic Actimab-A Binding Ig LikeLectin 3; gp67; CD33 Leukemia (AML; Acute Myeloblastic Leukemia);Relapsed Acute Myeloid Leukemia Lirilumab Killer Cell ImmunoglobulinLike Receptor 2DL1; Chronic Lymphocytic Leukemia (CLL); GastrointestinalTract CD158 Antigen Like Family Member A; MHC Cancer; Head and NeckCancer Squamous Cell Carcinoma; Class I NK Cell Receptor; CD158a;KIR2DL1 Hepatocellular Carcinoma; Melanoma; Myelodysplastic Antagonist;Killer Cell Immunoglobulin Like Syndrome; Non-Small Cell Lung Cancer;Refractory Acute Receptor 2DL2; CD158 Antigen Like Family MyeloidLeukemia; Refractory Chronic Lymphocytic Leukemia Member B1; MHC Class INK Cell Receptor; (CLL); Relapsed Acute Myeloid Leukemia; RelapsedChronic Natural Killer Associated Transcript 6; Lymphocytic Leukemia(CLL); Chronic Myelocytic Leukemia CD158b1; KIR2DL2 Antagonist; KillerCell (CML; Chronic Myeloid Leukemia); Hodgkin Lymphoma (B-CellImmunoglobulin Like Receptor 2DL3; MHC Hodgkin Lymphoma); MetastaticHormone Refractory Class I NK Cell Receptor; Killer Inhibitory(Castration Resistant; androgen-Independent) Prostate Receptor cl 2-3;Natural Killer Associated Cancer; Non-Hodgkin Lymphoma; RefractoryMultiple Myeloma; Transcript 2; CD158b2; KIR2DL3 Antagonist RelapsedMultiple Myeloma Lodelcizumab Proprotein Convertase Subtilisin/KexinType Bacterial Sepsis; Inflammation; Hypercholesterolemia 9; ProproteinConvertase 9; Neural Apoptosis Regulated Convertase 1; Subtilisin/KexinLike Protease PC9; PCSK9; EC 3.4.21. Lokivetmab Interleukin 31 canineatopic dermatitis Lorvotuzumab, Neural Cell Adhesion Molecule 1; AntigenOvarian Cancer; Non-Small Cell Lung Cancer; Skin Cancer; LorvotuzumabRecognized By Monoclonal Antibody 5.1H11; Neuroendocrine Tumors;Small-Cell Lung Cancer; mertansine CD56; NCAMI Neuroendocrine Carcinoma;Refractory Multiple Myeloma; Relapsed Multiple Myeloma LosatuxizumabEpidermal Growth Factor Receptor; Proto Head and Neck Cancer SquamousCell Carcinoma; Metastatic Oncogene c ErbB 1; Receptor Tyrosine ProteinColorectal Cancer; Non-Small Cell Lung Cancer; Solid Tumor Kinase erbB1; HER1; ERBB1; EGFR; EC 2.7.10.1 Lpathomab Lysophosphatidic Acid; LPANeuropathic Pain; Traumatic Brain Injury; Chronic Pain; PostherpeticNeuralgia; Spinal Cord Injury Kidney Fibrosis Diabetic NeuropathyPulmonary Fibrosis Chemotherapy Induced Peripheral Neuropathy Wet(Neovascular/Exudative) Macular Degeneration Lucatumumab CD40 Ligand; TCell Antigen Gp39; TNF Related Follicular Lymphoma; Hematological Tumor;Multiple Myeloma Activation Protein; Tumor Necrosis Factor (KehlerDisease); Non-Hodgkin Lymphoma; Chronic Ligand Superfamily Member 5;CD154; Lymphocytic Leukemia (CLL); Hodgkin Lymphoma (B-Cell CD40LG;Tumor Necrosis Factor Receptor Hodgkin Lymphoma) Superfamily Member 5; BCell Surface Antigen CD40; Bp50; CDw40; CD40L Receptor; TNFRSF5; CD40Lulizumab T Cell Specific Surface Glycoprotein CD28; Sicca Syndrome(Sjogren); Systemic Lupus Erythematosus TP44; CD28 Lulizumab pegol TCell Specific Surface Glycoprotein CD28; Sicca Syndrome (Sjogren);Systemic Lupus Erythematosus TP44; CD28 Lumiliximab Low AffinityImmunoglobulin Epsilon Fc Atopic Dermatitis Chronic Lymphocytic Leukemia(CLL) Allergic Receptor; BLAST 2; C Type Lectin Domain Asthma AllergicRhinitis Family 4 Member J; Fc Epsilon RII; Immunoglobulin E BindingFactor; Lymphocyte IgE Receptor; CD23; FCER2 Lumretuzumab ReceptorTyrosine Protein Kinase ERBB 3; Metastatic Breast Cancer; Non-Small CellLung Cancer; Proto Imogene Like Protein c ErbB 3; Squamous Non-SmallCell Lung Cancer;; Colorectal Cancer; Tyrosine Kinase Type Cell SurfaceReceptor Head and Neck Cancer Squamous Cell Carcinoma; Non-Small HER3;HER3; ERBB3; EC 2.7.10.1 Cell Lung Cancer Lupartumab HUMAN GPI-ANCHOREDCELL SURFACE- Neoplastics ASSOCIATED PROTEIN C4.4A Lutikizumab IL1A;interleukin 1 alpha and interleukin 1 beta; Osteoarthritis (OA) IL1BMapatumumab Tumor Necrosis Factor Receptor Superfamily HepatocellularCarcinoma; Cervical Cancer; Non-Hodgkin Member 10A; Death Receptor 4;TNF Related Lymphoma; Non-Small Cell Lung Cancer; Refractory MultipleApoptosis Inducing Ligand Receptor 1; TRAIL Myeloma; Relapsed MultipleMyeloma Receptor 1; DR4; CD261; TNFRSF10A Margetuximab Receptor TyrosineProtein Kinase ERBB 2; Metastatic Breast Cancer; Breast Cancer; GastricCancer; Metastatic Lymph Node Gene 19 Protein; Proto Gastroesophageal(GE) Junction Carcinomas; Colorectal Oncogene Neu; Proto Oncogene C ErbB2; Cancer; Esophageal Cancer; Head and Neck Cancer; Tyrosine Kinase TypeCell Surface Receptor Hepatocellular Carcinoma; Cervical Cancer;Non-Hodgkin HER2; p185erbB2; HER2; CD340; ERBB2; EC Lymphoma; Non-SmallCell Lung Cancer; Refractory Multiple 2.7.10.1 Myeloma; RelapsedMultiple Myeloma; Solid Tumor Marzeptacog Coagulation Factor VII;Proconvertin; Serum Hemophilia A; Hemophilia B alfa ProthrombinConversion Accelerator; SPCA; Eptacog Alfa; F7; EC 3.4.21.21 MatuzumabEpidermal Growth Factor Receptor; Proto Lung Cancer; Ovarian Cancer;Non-Small Cell Lung Cancer; Oncogene c ErbB 1; Receptor Tyrosine ProteinNon-Small Cell Lung Cancer; Esophageal Cancer; Gastric Kinase erbB 1;HER1; ERBB1; EGFR; EC 2.7.10.1 Cancer; Metastatic Colorectal CancerMavrilimumab Granulocyte Colony Stimulating Factor Rheumatoid ArthritisReceptor; CD114; GCSFR; CSF3R MDX-1303, Anthrax Protective Antigen; paAnthrax Valortim Mepolizumab Interleukin 5; Eosinophil DifferentiationHypereosinophilic Syndrome; Nasal Polyps; Atopic Dermatitis; Factor; BCell Differentiation Factor 1; T Cell Asthma; Chronic ObstructivePulmonary Disease (COPD); Replacing Factor; IL5 Churg-Strauss Syndrome;Hypereosinophilic Syndrome Metelimumab Transforming Growth Factor Beta1; TGFB1 Systemic Sclerosis (Scleroderma) Milatuzumab HLA Class IIHistocompatibility Antigen B-Cell Non-Hodgkin Lymphoma; Systemic LupusGamma Chain; HLA DR Antigens Associated Erythematosus; Graft Versus HostDisease (GVHD); Chronic Invariant Chain; 1a Antigen AssociatedLymphocytic Leukemia (CLL); Refractory Multiple Myeloma; InvariantChain; p33; CD74 Relapsed Multiple Myeloma Mirvetuximab Folate ReceptorAlpha; Adult Folate Binding Metastatic Breast Cancer; Fallopian TubeCancer; Epithelial soravtansine Protein; Folate Receptor 1; KB CellsFBP; Ovarian Cancer; Peritoneal Cancer; Renal Cell Carcinoma; OvarianTumor Associated Antigen M0v18; Non-Small Cell Lung Cancer; EndometrialCancer; FOLRI” Adenocarcinoma Modotuximab Epidermal Growth FactorReceptor; Proto Esophageal Cancer; Solid Tumor; Glioblastoma MultiformeOncogene c ErbB 1; Receptor Tyrosine Protein (GBM); MetastaticColorectal Cancer; Recurrent Head and Kinase erbB 1; HER1; ERBB1; EGFR;EC 2.7.10.1 Neck Cancer Squamous Cell Carcinoma; Squamous Non-Small CellLung Cancer Mogamulizumab C-C Chemokine Receptor Type 4; K5-5; CD194;Allergic Rhinitis; Asthma; T-Cell Leukemia; T-Cell Lymphomas; CCR4Breast Cancer; Gastric Cancer; Non-Small Cell Lung Cancer; Solid Tumor;Cutaneous T-Cell Lymphoma; Peripheral T-Cell Lymphomas (PTCL); T-CellLeukemia; T-Cell Lymphomas Monalizumab NKG2 A/NKG2 B Type II IntegralMembrane Cervical Cancer; Chronic Lymphocytic Leukemia (CLL); Protein;NK Cell Receptor A; NKG2 A/B Endometrial Cancer; Fallopian Tube Cancer;Ovarian Cancer; Activating NK Receptor; CD159a; KLRC1 Peritoneal Cancer;Recurrent Head and Neck Cancer Squamous Cell Carcinoma; RefractoryChronic Lymphocytic Leukemia (CLL); Relapsed Chronic LymphocyticLeukemia (CLL); Rheumatoid Arthritis; Oral Cavity (Mouth) Cancer;Squamous Cell Carcinoma Motavizumab Respiratory Syncytial Virus FusionProtein; Respiratory Syncytial Virus (RSV) Infections RSV F ProteinMoxetumomab, B Cell Receptor CD22; B Lymphocyte Cell Hairy CellLeukemia; Acute Lymphocytic Leukemia (ALL; Acute Moxetumomab AdhesionMolecule; Sialic Acid Binding Ig Like Lymphoblastic Leukemia);Follicular Lymphoma; Relapsed pasudotox Lectin 2; T Cell Surface AntigenLau 14; CD22 Chronic Lymphocytic Leukemia (CLL); Refractory ChronicLymphocytic Leukemia (CLL); Diffuse Large B-Cell Lymphoma; B-CellNon-Hodgkin Lymphoma; Mantle Cell Lymphoma Muromonab-CD3 T Cell SurfaceGlycoprotein CD3 Epsilon Heart Transplant Rejection; Kidney TransplantRejection; Liver Chain; T Cell Surface Antigen T3/Leu 4 EpsilonTransplant Rejection Chain; CD3E Namilumab Granulocyte Macrophage ColonyStimulating Rheumatoid Arthritis; Plaque Psoriasis (Psoriasis Vulgaris)Factor; GMCSF; Colony Stimulating Factor; CSF; Molgramostin;Sargramostim; CSF2 Naptumomab Trophoblast Glycoprotein; M6P1; 5T4 RenalCell Carcinoma; Non-Small Cell Lung Cancer; Pancreatic estafenatoxOncofetal Antigen; 5T4 Oncofetal Trophoblast Cancer; Advanced MalignancyGlycoprotein; Wnt Activated Inhibitory Factor 1; TPBG NarnatumabMacrophage Stimulating Protein Receptor; Advanced Malignancy; SolidTumor CDw136; Protein Tyrosine Kinase 8; p185 Ron; CD136; MST1R; EC2.7.10.1 Natalizumab Integrin Alpha 4; CD49 Antigen Like Family AcuteIschemic Stroke; Multiple Sclerosis; Rheumatoid Member D; VLA4 SubunitAlpha; CD49d; ITGA4 Arthritis; Paraneoplastic Syndrome; Graft VersusHost Disease (GVHD); Crohn's Disease (Regional Enteritis); RelapsingRemitting Multiple Sclerosis (RRMS) Navicixizumab Delta Like Protein 4;Delta Like Ligand 4; Ovarian Cancer; Uterine Cancer; Fallopian TubeCancer; Solid Drosophila Delta Homolog 4; DLL4; Vascular Tumor;Metastatic Colorectal Cancer; Peritoneal Cancer Endothelial GrowthFactor; VEGF Navivumab Influenza A virus hemagglutinin HA InfectiousDisease Ndimab-varB Nerve growth factor Chronic Pancreatitis Pain;Sciatic Pain; Vertebral Fracture Pain; Cancer Pain; Chronic Pain;Osteoarthritis Pain; Low Back Pain Necitumumab Epidermal Growth FactorReceptor; Proto Metastatic Colorectal Cancer; Non-Small Cell LungCancer; Oncogene c ErbB 1; Receptor Tyrosine Protein Squamous Non-SmallCell Lung Cancer Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 NeliximabV Type Proton Atpase 116 Kda Subunit A Heart Transplant Rejection;Kidney Transplant Rejection; Isoform 3; Osteoclastic Proton Pump 116 kDaInflammation; Arthritis Subunit; T Cell Immune Regulator 1; T CellImmune Response cDNA7 Protein; Vacuolar Proton Translocating ATPase 116kDa Subunit A Isoform 3; TCIRG1; EC 3.6.3.6 Nemolizumab Interleukin 31Receptor Subunit Alpha; Pruritus; Atopic Dermatitis Cytokine ReceptorLike 3; Gp130 Like Monocyte Receptor; GLM R; ZcytoR17; IL31RA NesvacumabAngiopoietin 2; Ang 2; ANGPT2; Placenta Diabetic Macular Edema; Wet(Neovascular/Exudative) Growth Factor; Vascular Endothelial GrowthMacular Degeneration Factor Related Protein; PGF; Vascular EndothelialGrowth Factor A; Vascular Permeability Factor; VEGFA; VascularEndothelial Growth Factor B; VEGF Related Factor; VEGFB NeuradiabTenascin; Cytotactin; GMEM; GP 150-225; Non-Hodgkin Lymphoma;Glioblastoma Multiforme (GBM); Brain Glioma Associated ExtracellularMatrix Cancer Antigen; Hexabrachion; JI; Myotendinous Antigen;Neuronectin; Tenascin C; TNC Nimotuzumab Epidermal Growth FactorReceptor; Proto Gastric Cancer; Glioblastoma Multiforme (GBM); PediatricOncogene c ErbB 1; Receptor Tyrosine Protein Diffuse Intrinsic PontineGlioma; Adenocarcinoma Of The Kinase erbB 1; HER1; ERBB1; EGFR; EC2.7.10.1 Gastroesophageal Junction; Gastric Cancer; MetastaticAdenocarcinoma of The Pancreas; Non-Small Cell Lung Cancer;Nasopharyngeal Cancer; Oropharyngeal Cancer; Cervical Cancer; MetastaticBreast Cancer; Hypopharyngeal Cancer; Squamous Non-Small Cell LungCarcinoma Nivolumab Programmed Cell Death Protein 1; PDI; CD279;Squamous Non-Small Cell Lung Cancer Metastatic Melanoma; PDCDIMetastatic Renal Cell Carcinoma; Squamous Non-Small Cell Lung CancerMetastatic Melanoma; Metastatic Renal Cell Carcinoma; Non-Small CellLung Cancer Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); MetastaticMelanoma; Metastatic Renal Cell Carcinoma; Recurrent Head and NeckCancer Squamous Cell Carcinoma; Squamous Non-Small Cell Lung Cancer;Transitional Cell Cancer (Urothelial Cell Cancer) Hodgkin Lymphoma(B-Cell Hodgkin Lymphoma); Metastatic Melanoma; Renal Cell Carcinoma;Squamous Non-Small Cell Lung Cancer Hodgkin Lymphoma (B-Cell HodgkinLymphoma); Squamous Non-Small Cell Lung Cancer Hodgkin Lymphoma (B- CellHodgkin Lymphoma); Metastatic Melanoma; Metastatic Renal Cell Carcinoma;Squamous Non-Small Cell Lung Cancer Gastric Cancer Non-Small Cell LungCancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma; RenalCell Carcinoma Transitional Cell Cancer (Urothelial Cell Cancer)Malignant Pleural Mesothelioma; Small-Cell Lung Cancer Esophageal CancerGastric Cancer; Gastroesophageal (GE) Junction Carcinomas GlioblastomaMultiforme (GBM) Head and Neck Cancer Squamous Cell Carcinoma;Transitional Cell Carcinoma (Urothelial Cell Carcinoma) Head and NeckCarcinoma Hepatocellular Carcinoma; Non-Small Cell Lung Cancer; RenalCell Carcinoma; Small-Cell Lung Cancer; Transitional Cell Cancer(Urothelial Cell Cancer) Malignant Pleural Mesothelioma; Ovarian CancerEsophageal Cancer; Gastric Cancer; Gastroesophageal (GE) JunctionCarcinomas; Hepatocellular Carcinoma; Metastatic Renal Cell Carcinoma;Non-Small Cell Lung Cancer; Recurrent Glioblastoma Multiforme (GBM);Refractory Multiple Myeloma; Relapsed Multiple Myeloma Acute MyelocyticLeukemia (AML; Acute Myeloblastic Leukemia); B-Cell Non-HodgkinLymphoma; Bladder Cancer; Chronic Lymphocytic Leukemia (CLL); PancreaticDuctal Adenocarcinoma; Refractory Chronic Lymphocytic Leukemia (CLL);Relapsed Chronic Lymphocytic Leukemia (CLL) Metastatic Breast Cancer;Ovarian Cancer; Primary CNS Lymphoma; Testicular Cancer HumanPapillomavirus Infections Adenocarcinoma; Anal Cancer; Cutaneous T-CellLymphoma; Gastric Cancer; Gastroesophageal (GE) Junction Carcinomas;Merkel Cell Carcinoma; Metastatic Colorectal Cancer; Papillary Tumor;Peripheral T-Cell Lymphomas (PTCL); Signet Ring Cell Squamous CellCarcinoma Cervical Cancer; Nasopharyngeal Cancer; Skin Cancer; VaginalCancer; Vulvar Cancer Endometrial Cancer; Fallopian Tube Cancer;Peritoneal Cancer; Primary ENS Lymphoma; Soft Tissue Sarcoma; TesticularCancer; Uterine Cancer Ovarian Cancer Bladder Cancer Acute MyelocyticLeukemia (AML; Acute Myeloblastic Leukemia); Gastric Cancer CervicalCancer; Colon Cancer; Diffuse Large B-Cell Lymphoma; FollicularLymphoma; Nasopharyngeal Cancer; Pancreatic Cancer; Skin Cancer; VaginalCancer; Vulvar Cancer Sepsis Bile Duct Cancer (Cholangiocarcinoma);Solid Tumor Metastatic Hormone Refractory (Castration Resistant;androgen-Independent) Prostate Cancer; Non-Small Cell Lung CancerHepatitis C Chronic Myelocytic Leukemia (CML; Chronic Myeloid Leukemia)Oral Cavity (Mouth) Cancer Leptomeningeal Disease (NeoplasticMeningitis; Leptomeningeal Carcinomatosis) Metastatic Melanoma GastricCancer; Non-Small Cell Lung Cancer; Renal Cell Carcinoma; Small-CellLung Cancer Gastroesophageal (GE) Junction Carcinomas Head and NeckCancer Malignant Pleural Mesothelioma Metastatic Renal Cell CarcinomaRecurrent Glioblastoma Multiforme (GBM) Bladder Cancer; Breast Cancer;Ewing Sarcoma; Hepatocellular Carcinoma; Hodgkin Lymphoma (B-CellHodgkin Lymphoma); Malignant Pleural Mesothelioma; Metastatic ColorectalCancer; Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Metastatic Pancreatic Cancer; MetastaticTransitional (Urothelial) Tract Cancer; Metastatic Uveal Melanoma;Neuroblastoma; Non-Hodgkin Lymphoma; Non-Small Cell Lung Cancer;Osteosarcoma; Primitive Neuroectodermal Tumor (PNET); RhabdomyosarcomaMelanoma Merkel Cell Carcinoma; Metastatic Hrmone Refractory (CastrationResistant; androgen-Independent) Prostate Cancer; Non-Small Cell LungCancer Epithelial Ovarian Cancer; Fallopian Tube Cancer; PeritonealCancer Obiltoxaximab Anthrax Protective Antigen; pa Anthrax ObinutuzumabB Lymphocyte Antigen CD20; B Lymphocyte Graft Versus Host Disease(GVHD); Waldenstrom Surface Antigen B1; Bp35; Leukocyte SurfaceMacroglobulinemia; End-Stage Kidney Disease (End-Stage Antigen Leu 16;Membrane Spanning 4 Renal Disease; ESRD); Diffuse Large B-Cell Lymphoma;Domains Subfamily A Member 1; CD20; MS4A1 Follicular Lymphoma; SplenicMarginal Zone B-Cell Lymphoma Lupus Nephritis; Non-Hodgkin Lymphoma;Chronic Lymphocytic Leukemia (CLL); Follicular Lymphoma Ocaratuzumab BLymphocyte Antigen CD20: B Lymphocyte Follicular Lymphoma; Lymphoma;Rheumatoid Arthritis; Surface Antigen B1; Bp35; Leukocyte SurfaceSystemic Lupus Erythematosus; Chronic Lymphocytic Antigen Leu 16;Membrane Spanning 4 Leukemia (CLL) Domains Subfamily A Member 1; CD20;MS4A1 Ocrelizumab B Lymphocyte Antigen CD20; B Lymphocyte FollicularLymphoma; Rheumatoid Arthritis; Lupus Nephritis; Surface Antigen B1;Bp35; Leukocyte Surface Systemic Lupus Erythematosus; PrimaryProgressive Multiple Antigen Leu 16; Membrane Spanning 4 Sclerosis(PPMS); Relapsing Multiple Sclerosis (RMS); Domains Subfamily A Member1; CD20; MS4A1 Odulimomab Integrin Alpha L; CD11 Antigen Like FamilyMultiple Sclerosis; Graft Versus Host Disease (GVHD); Kidney Member A;Leukocyte Adhesion Glycoprotein Transplant Rejection LFA 1 Alpha Chain;CD11a; ITGAL Ofatumumab CD20; B Lymphocyte Surface Antigen B1; RelapsingRemitting Multiple Sclerosis (RRMS); Secondary Bp35; Leukocyte SurfaceAntigen Leu 16; Progressive Multiple Sclerosis (SPMS) B-Cell Non-HodgkinMembrane Spanning 4 Domains Subfamily A Lymphoma; Neuromyelitis Optica(Devic's Syndrome); Member 1; CD20; MS4A1 Rheumatoid Arthritis; DiffuseLarge B-Cell Lymphoma; Diffuse Large B-Cell Lymphoma; WaldenstromMacroglobulinemia; Pemphigus Vulgaris; Rheumatoid Arthritis; RefractoryChronic Lymphocytic Leukemia (CLL); Chronic Lymphocytic Leukemia (CLL);Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed ChronicLymphocytic Leukemia (CLL)” Olaratumab Platelet Derived Growth FactorReceptor; Epithelial Ovarian Cancer; Fallopian Tube Cancer; PDGFR; EC2.7.10.1; Platelet Derived Growth Gastrointestinal Stromal Tumor (GIST);Metastatic Hormone Factor Receptor Alpha; Alpha Type Platelet Refractory(Castration Resistant; androgen-Independent) Derived Growth FactorReceptor; CD140 Prostate Cancer; Peritoneal Cancer; RecurrentGlioblastoma Antigen Like Family Member A; Platelet Multiforme (GBM);Metastatic Pancreatic Cancer; Non-Small Derived Growth Factor Receptor2; CD140a; Cell Lung Cancer; Soft Tissue Sarcoma PDGFRA; EC 2.7.10.1Oleclumab 5′ Nucleotidase; Ecto 5′ Nucleotidase; CD73; ColorectalCancer; Pancreatic Cancer NT5E; EC 3.1.3.5 Olokizumab Interleukin 6; BCell Stimulatory Factor 2; Rheumatoid Arthritis; Crohn's Disease(Regional Enteritis) BSF2; CTL Differentiation Factor; CDF; HybridomaGrowth Factor; Interferon Beta 2; IFNB2; IL6 Omalizumab ImmunoglobulinE; IgE Kidney Disease; Rhino-Conjunctivitis; Nasal Polyposis;Rhinosinusitis; Asthma; Allergic Asthma; Chronic Urticaria; HivesOnartuzumab Hepatocyte Growth Factor Receptor; Proto Gastric Cancer;Hepatocellular Carcinoma; Metastatic Breast Oncogene c Met; TyrosineProtein Kinase Met; Cancer; Metastatic Colorectal Cancer; Non-Small CellLung HGF/SF Receptor; Scatter Factor Receptor; Cancer; RecurrentGlioblastoma Multiforme (GBM); Non-Small MET; EC 2.7.10.1 Cell LungCancer; Metastatic Melanoma; Recurrent Glioblastoma Multiforme (GBM)Ontuxizumab Endosialin; Tumor Endothelial Marker 1; CD164 MetastaticMelanoma; Solid Tumor; Metastatic Colorectal Sialomucin Like 1; CD248Cancer; Rhabdomyosarcoma; Soft Tissue Sarcoma; Lymphoma OpicinumabLeucine Rich Repeat and Immunoglobulin Like Optic Neuritis; RelapsingRemitting Multiple Sclerosis (RRMS); Domain Containing Nogo ReceptorInteracting Secondary Progressive Multiple Sclerosis (SPMS) Protein 1;Leucine Rich Repeat and Immunoglobulin Domain Containing Protein 1;Leucine Rich Repeat Neuronal Protein 1; Leucine Rich Repeat NeuronalProtein 6A; LINGOI Oportuzumab Epithelial Cell Adhesion Molecule; Headand Neck Cancer Squamous Cell Carcinoma; Ovarian monatox AdenocarcinomaAssociated Antigen; Cell Cancer; Liver Cancer; Non Muscle InvasiveBladder Cancer Surface Glycoprotein Trop 1; Epithelial Cell (NMIBC)(Superficial Bladder Cancer) Surface Antigen; Epithelial Glycoprotein314; KS ¼ Antigen; KSA; Tumor Associated Calcium Signal Transducer 1;CD326; EPCAM Oregovomab Mucin 16; Ovarian Cancer Related TumorEpithelial Ovarian Cancer; Fallopian Tube Cancer; Ovarian Marker CA125;Ovarian Carcinoma Antigen Cancer; Pancreatic Ductal Adenocarcinoma;Peritoneal Cancer CA125; MUC16 Oreptacog, rFVIIa Hamophilie Oreptacogalfa Orticumab Oxidized low-density lipoprotein AtherosclerosisOtelixizumab T Cell Surface Glycoprotein CD3 Epsilon Graves'Ophthalmopathy; Type 1 Diabetes (Juvenile Diabetes); Chain; T CellSurface Antigen T3/Leu 4 Epsilon Myasthenia Gravis; Psoriasis;Rheumatoid Arthritis Chain; CD3E Otlertuzumab Leukocyte Antigen CD37;Tetraspanin 26; B-Cell Non-Hodgkin Lymphoma; Follicular Lymphoma; CD37Lymphoblastic Lymphoma; Non-Hodgkin Lymphoma; Relapsed ChronicLymphocytic Leukemia (CLL); Chronic Lymphocytic Leukemia (CLL) OxelumabTumor Necrosis Factor Ligand Superfamily Asthma Member 4; GlycoproteinGp34; OX40 Ligand; TAX Transcriptionally Activated Glycoprotein 1;CD252; TNFSF4 Ozanezumab Reticulon 4; Human NogoA; Neurite OutgrowthAmyotrophic Lateral Sclerosis; Relapsing Remitting Multiple Inhibitor;Foocen; Neuroendocrine Specific Sclerosis (RRMS) Protein; NeuroendocrineSpecific Protein C Homolog; RTN x; Reticulon 5; RTN4 Ozoralizumab TumorNecrosis Factor; Cachectin; TNF Alpha; Rheumatoid Arthritis TumorNecrosis Factor Ligand Superfamily Member 2; TNF a; TNF PagibaximabLipoteichoic Acid; LTA Bacterial Sepsis; Staphylococcal InfectionsPalivizumab Respiratory Syncytial Virus Fusion Protein; RespiratorySyncytial Virus (RSV) Infections RSV F Protein Pamrevlumab ConnectiveTissue Growth Factor; CCN Family Duchenne Muscular Dystrophy; PancreaticDuctal Member 2; Hypertrophic Chondrocyte Adenocarcinoma; IdiopathicPulmonary Fibrosis; Liver Fibrosis; Specific Protein 24; Insulin LikeGrowth Focal Segmental Glomerulosclerosis (FSGS); Microalbuminuria;Factor Binding Protein B; IGFBPB; CTGF Proteinuria; Systemic Sclerosis(Scleroderma); Diabetic Nephropathy; Type 1 Diabetes (JuvenileDiabetes); Type 2 Diabetes Panitumumab Epidermal Growth Factor Receptor;Proto Esophageal Cancer; Adenocarcinoma Of The Gastroesophageal Oncogenec ErbB 1; Receptor Tyrosine Protein Junction; Gastric Cancer; MetastaticBreast Cancer; Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 RecurrentHead and Neck Cancer Squamous Cell Carcinoma; Anal Cancer; Non-SmallCell Lung Cancer; Glioblastoma Multiforme (GBM); Gliosarcoma; MalignantGlioma; Muscle Invasive Bladder Cancer (MIBC); Non-Small Cell LungCancer; Renal Cell Carcinoma; Head and Neck Cancer Squamous CellCarcinoma; Metastatic Colorectal Cancer Pankomab, Mucin 1; BreastCarcinoma Associated Antigen Fallopian Tube Cancer; Epithelial OvarianCancer; Peritoneal Pankoab DF3; Episialin; H23AG; Krebs Von Den LungenCancer; Breast Cancer; Non-Small Cell Lung Cancer; 6; PEMT; PeanutReactive Urinary Mucin; Colorectal Cancer; Ovarian Cancer PolymorphicEpithelial Mucin; Tumor Associated Epithelial Membrane Antigen; TumorAssociated Mucin; CD227; MUC1; tumor specific glycosylation of MUC1Panobacumab Lipopolysaccharide; Endotoxin Ventilator AssociatedPneumonia (VAP); Hospital Acquired Pneumonia (HAP); Pseudomonasaeruginosa Pneumonia Parsatuzumab Epidermal Growth Factor Like Protein7; Solid Tumor; Metastatic Colorectal Cancer; Non-Small Cell MultipleEpidermal Growth Factor Like Lung Cancer; Solid Tumor Domains Protein 7;NOTCH4 Like Protein; Vascular Endothelial Statin; Zneu1; EGFL7Pascolizumab Interleukin 4; B Cell Stimulatory Factor 1; AsthmaBinetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4Pasotuxizumab Glutamate Carboxypeptidase 2; Folate Hormone Refractory(Castration Resistant; androgen- Hydrolase 1; Prostate Specific MembraneIndependent) Prostate Cancer Antigen; PSMA; Pteroylpoly Gamma GlutamateCarboxypeptidase; Cell Growth Inhibiting Gene 27 Protein; FOLH1; EC3.4.17.21; T Cell Surface Glycoprotein CD3 Epsilon Chain; T Cell SurfaceAntigen T3/Leu 4 Epsilon Chain; CD3E Pateclizumab Lymphotoxin Alpha; TNFBeta; Tumor Necrosis Rheumatoid Arthritis Factor Ligand SuperfamilyMember 1; LTA Patritumab Receptor Tyrosine Protein Kinase ERBB 3;Non-Small Cell Lung Cancer; Breast Cancer; Bladder Cancer; ProtoOncogene Like Protein c ErbB 3; Cervical Cancer; Colon Cancer;Endometrial Cancer; Tyrosine Kinase Type Cell Surface ReceptorEsophageal Cancer; Gastric Cancer; Liver Cancer; Ovarian HER3; HER3;ERBB3; EC 2.7.10.1 Cancer; Pancreatic Cancer; Prostate Cancer;Metastatic Breast Cancer; Recurrent Head and Neck Cancer Squamous CellCarcinoma Pembrolizumab Programmed Cell Death Protein 1; PD1; CD279;Metastatic Melanoma; Non-Small Cell Lung Cancer Metastatic PDCD1Melanoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); MetastaticMelanoma; Non-Small Cell Lung Cancer; Recurrent Head and Neck CancerSquamous Cell Carcinoma; Metastatic Melanoma; Non-Small Cell LungCancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma;Colorectal Cancer; Metastatic Transitional (Urothelial) Tract Cancer;Non-Small Cell Lung Cancer; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma);Adenocarcinoma Of The Gastroesophageal Junction; Gastric Cancer; BreastCancer; Metastatic Breast Cancer; Metastatic Renal Cell Carcinoma;Multiple Myeloma (Kahler Disease); Refractory Multiple Myeloma;Non-Small Cell Lung Cancer Adenocarcinoma Of The GastroesophagealJunction; Esophageal Cancer; Gastric Cancer; Hepatocellular Carcinoma;Hypopharyngeal Cancer; Laryngeal Cancer; Metastatic Transitional(Urothelial) Tract Cancer; Oral Cavity (Mouth) Cancer; OropharyngealCancer; Refractory Multiple Myeloma; Ureter Cancer; Urethral CancerBladder Cancer; Recurrent Head and Neck Cancer Squamous Cell CarcinomaAdenocarcinoma Of The Gastroesophageal Junction; Esophageal Cancer;Mantle Cell Lymphoma; Merkel Cell Carcinoma; Metastatic Biliary TractCancer; Small-Cell Lung Cancer; Squamous Cell Carcinoma Anal Cancer;Basal Cell Carcinoma (Basal Cell Epithelioma); Cervical Cancer;Chondrosarcoma; Dedifferentiated Liposarcoma; Diffuse Large B-CellLymphoma; Endometrial Cancer; Epithelial Ovarian Cancer; Ewing Sarcoma;Fallopian Tube Cancer; Follicular Lymphoma; Germinomatous (Seminomatous)Germ Cell Tumors; Gliosarcoma; Leiomyosarcoma; Lymphoma; MalignantPleural Mesothelioma; Metastatic Colorectal Cancer; Metastatic ProstateCancer; Metastatic Renal Cell Carcinoma; Nasopharyngeal Cancer;Neuroblastoma; Neuroendocrine Tumors; Non Muscle Invasive Bladder Cancer(NMIBC) (Superficial Bladder Cancer); Non-Hodgkin Lymphoma;Nongerminomatous (Nonseminomatous) Germ Cell Tumors; Osteosarcoma;Pancreatic Cancer; Peripheral Nerve Sheath Tumor (Neurofibrosarcoma);Peritoneal Cancer; Primary Mediastinal B-Cell Lymphoma; RecurrentGlioblastoma Multiforme (GBM); Salivary Gland Cancer; Small-Cell LungCancer; Soft Tissue Sarcoma; Synovial Sarcoma; T-Cell Lymphomas; ThymicCarcinoma; Thyroid Cancer Adenoid Cystic Carcinoma (ACC); ChronicIdiopathic Myelofibrosis; Chronic Lymphocytic Leukemia (CLL); DiffuseLarge B-Cell Lymphoma; Post-Essential Thrombocythemia Myelofibrosis(Post-ET MF); Post-Polycythemia Vera Myelofibrosis (PPV-MF); Small-CellLung Cancer; Soft Tissue Sarcoma Metastatic Melanoma Chronic LymphocyticLeukemia (CLL); Lymphoma; Mycosis Fungoides; Myelodysplastic Syndrome;Non-Hodgkin Lymphoma; Sezary Syndrome Melanoma; Metastatic BreastCancer; Neuroendocrine Gastroenteropancreatic Tumors (GEP-NET)Perakizumab Interleukin 17; IL17 Psoriatic Arthritis; AutoimmuneDisorders; Inflammation; Rheumatoid Arthritis Pertuzumab, ReceptorTyrosine Protein Kinase ERBB 2; Non-Small Cell Lung Cancer; PancreaticCancer; Hormone Pertuzuab Metastatic Lymph Node Gene 19 Protein; ProtoRefractory (Castration Resistant; androgen-Independent) Oncogene Neu;Proto Oncogene C ErbB 2; Prostate Cancer; Neuroendocrine Cancer;Adenocarcinoma Of Tyrosine Kinase Type Cell Surface Receptor TheGastroesophageal Junction; Breast Cancer; Epithelial HER2; pI85erbB2;HER2; CD340; ERBB2; EC Ovarian Cancer; Fallopian Tube Cancer; GastricCancer; 2.7.10.1; HER2/neu Metastatic Breast Cancer; Peritoneal Cancer;Breast Cancer; Metastatic Breast Cancer Pexelizumab, Complement C5; C3and PZP Like Alpha 2 Coronary Disease; Myocardial Infarction; Reductionof Side Pexelizumab Macroglobulin Domain Containing Protein 4; Effectsof Cardiac Surgery h5g1.1 C5 PF-05082566, Tumor Necrosis Factor ReceptorSuperfamily Non-Small Cell Lung Cancer; Colorectal Cancer; MetastaticUtomilumab Member 9; 4-IBB Ligand Receptor; T Cell Breast Cancer;Small-Cell Lung Cancer; Head and Neck Cancer Antigen 4-IBB Homolog; TCell Antigen ILA; Squamous Cell Carcinoma; Metastatic Melanoma; OvarianCD137; TNFRSF9 Cancer; Renal Cell Carcinoma; Follicular Lymphoma;Cervical Cancer; Pancreatic Cancer; Gastric Cancer; Bladder Cancer;Diffuse Large B-Cell Lymphoma; Sarcomas; Anaplastic Thyroid Cancer;Metastatic Hepatocellular Carcinoma (HCC); Thymoma (Thymic EpithelialTumor) Pidilizumab Programmed Cell Death 1; PD-1; PDCD1; Pontine Glioma;Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Hepatitis C;Hepatocellular Carcinoma; Metastatic Colorectal Cancer; PancreaticCancer Pinatuzumab, B Cell Receptor CD22; B Lymphocyte Cell FollicularLymphoma; Chronic Lymphocytic Leukemia (CLL); Pinatuzumab AdhesionMolecule; Sialic Acid Binding Ig Like Diffuse Large B-Coll Lymphomavedotin Lectin 2; T Cell Surface Antigen Lou 14; CD22 Placulumab TumorNecrosis Factor; Cachectin; TNF Alpha; Sciatica; Plague Psoriasis(Psoriasis Vulgaris); Rheumatoid Tumor Necrosis Factor LigandSuperfamily Arthritis Member 2; TNF a; TNF Plozalizumab C-C ChemokineReceptor Type 2; Monocyte Rheumatoid Arthritis; Bone Metastasis;Diabetic Nephropathy; Chemoattractant Protein 1 Receptor; CD192;Relapsing Remitting Multiple Sclerosis (RRMS); CCR2 Atherosclerosis;Melanoma; Solid Tumor Pogalizumab Tumor Necrosis Factor ReceptorSuperfamily Solid Tumor; Metastatic Transitional (Urothelial) TractCancer Member 4; ACT35 Antigen; TAX Transcriptionally ActivatedGlycoprotein 1 Receptor; DX40L Receptor; CD134; TNFRSF4 Polatuzumab, BCell Antigen Receptor Complex Associated Follicular Lymphoma; DiffuseLarge B-Cell Lymphoma; B-Cell Polatuzumab Protein Beta Chain; B CellSpecific Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia (CLL);vedotin, Glycoprotein B29; Ig Beta; Immunoglobulin Mantle Cell LymphomaPolatuzuab Associated B29 Protein; CD79B Ponezumab Amyloid Beta Peptide;A beta P; Abeta; Beta Alzheimer's Disease; Neurodegenerative DiseasesAmyloid Porgaviximab Ebolavirus glycoprotein Ebola virus infectionsPrezalumab ICOS Ligand; B7 Homolog 2; B7 Like Protein Subacute CutaneousLupus Erythematosus (SCLE); Psoriasis; G150; B7 Related Protein 1;CD275; ICOSLG Systemic Lupus Erythematosus; Sicca Syndrome (Sjogren)Pritoxaximab Shiga Toxin Type 1; stx1; Shiga Toxin Type 2; Escherichiacoli Infections; Typical Hemolytic Uremic stx2 Syndrome (Shiga-ToxinAssociated Hemolytic Uremic Syndrome); Typical Hemolytic Uremic Syndrome(Shiga-Toxin Associated Hemolytic Uremic Syndrome) Pritumumab Vimentin;Epididymis Luminal Protein 113; VIM Glioma; Pancreatic Cancer DuilizumabImmunoglobulin E; IgE Allergic Asthma; Allergic Rhinitis; ChronicUrticaria; Hives Racotumomab N Glycolylneuraminyl Lactosylceramide;Breast Cancer; Melanoma; Small-Cell Lung Cancer; Ewing NeuGcGM3 Sarcoma;Glioma; Retinoblastoma; Wilms' Tumor (Nephroblastoma); Neuroblastoma;Non-Small Cell Lung Cancer Radretumab Fibronectin; Cold InsolubleGlobulin; FN1 Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Lung Cancer;Prostate Cancer; Metastatic Brain Tumor; Non-Small Cell Lung Cancer;Colorectal Cancer Rafivirumab Rabies Virus Glycoprotein RabiesRalpancizumab Neural Apoptosis-regulated Proteinase 1 dyslipidemia;Hypercholesterolemia; Hyperlipidemia Ramucirumab Vascular EndothelialGrowth Factor Receptor Adenocarcinoma Of The Gastroesophageal Junction;Gastric 2; Fetal Liver Kinase 1; Kinase Insert Domain Cancer; MetastaticColorectal Cancer; Non-Small Cell Lung Receptor; Protein Tyrosine KinaseReceptor Cancer; Gastric Cancer; Metastatic Colorectal Cancer; Non- flk1; VEGFR2; CD309; KDR; EC 2.7.10.1 Small Cell Lung Cancer; EpithelialOvarian Cancer; Fallopian Tube Cancer; Gallbladder Cancer; MetastaticBiliary Tract Cancer; Metastatic Breast Cancer; Metastatic Renal CellCarcinoma; Peritoneal Tumor; Mantle Cell Lymphoma; NeuroendocrineTumors; Hepatocellular Carcinoma; Metastatic Hormone Refractory(Castration Resistant; androgen- Independent) Prostate Cancer;Metastatic Melanoma; Recurrent Glioblastoma Multiforme (GBM); MetastaticBreast Cancer Ranevetmab Canine Nerve Growth Factor; NGF Pain;Osteoarthritis Ranibizumab, Vascular Endothelial Growth Factor ReceptorRetinal Vein Occlusion; Age Related Macular Degeneration; Ranibizivab 2;Fetal Liver Kinase 1; Kinase Insert Domain Diabetic Macular Edema;Diabetic Macular Edema; Diabetic Receptor; Protein Tyrosine KinaseReceptor Retinopathy; Non-Proliferative Diabetic Retinopathy (NPDR); flk1; VEGFR2; CD309; KDR; EC 2.7.10.1; VEGF-A Proliferative DiabeticRetinopathy (PDR); Choroidal Neovascularization; Macular Edema; Wet(Neovascular/ Exudative) Macular Degeneration; Macular Edema; Wet(Neovascular/Exudative) Macular Degeneration; Retinopathy OfPrematurity; Epistaxis; Corneal Neovascularization; Cystoid MacularEdema; Macular Edema; Polypoidal Choroidal Vasculopathy; Pterygium;Retinal Vein Occlusion; Uveitis Raxibacumab Anthrax Protective Antigen;pa Anthrax Refanezumab Myelin Associated Glycoprotein; Siglec 4a;Ischemic Stroke Sialic Acid Binding Ig Like Lectin 4A; MAG RegavirumabHuman Cytomegalovirus Envelope Cytomegalovirus (HHV-5) InfectionsGlycoprotein B; gB REGN2810 Programmed Cell Death Protein 1; PD1; CD279;Melanoma; Squamous Cell Carcinoma; Non-Small Cell Lung PDCD1 Cancer;Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); HodgkinLymphoma (B-Cell Hodgkin Lymphoma); Solid Tumor; B-Cell Non-HodgkinLymphoma; Basal Cell Carcinoma (Basal Cell Epithelioma) RemtolumabInterleukin 17A; Cytotoxic T Lymphocyte Rheumatoid Arthritis; PsoriaticArthritis; Systemic-Onset Associated Antigen B; CTLA8; IL17A; TumorJuvenile Idiopathic Arthritis (Still Disease) Necrosis Factor;Cachectin; TNF Alpha; Tumor Necrosis Factor Ligand Superfamily Member 2;TNF a; TNF Reslizumab Interleukin 5; Eosinophil Differentiation Asthma;Churg-Strauss Syndrome; Hypereosinophilic Factor; B Cell DifferentiationFactor 1; T Cell Syndrome; Eosinophilic Esophagitis Replacing Factor;IL5 rhuMAb-VEGF Vascular Endothelial Growth Factor A; Breast Cancer;Lung Cancer; Ovarian Cancer; Glioblastoma Vascular Permeability Factor;VEGFA Multiforme (GBM); Glioma; Renal Cell Carcinoma; Non-Small CellLung Cancer; Fallopian Tube Cancer; Epithelial Ovarian Cancer;Colorectal Cancer; Cervical Cancer; Metastatic Breast Cancer; MalignantGlioma; Metastatic Colorectal Cancer; Metastatic Ovarian Cancer;Metastatic Renal Cell Carcinoma; Peritoneal Cancer RilotumumabHepatocyte Growth Factor; Hepatopoietin A; Adenocarcinoma Of TheGastroesophageal Junction; Gastric Scatter Factor; HGF Cancer;Gliosarcoma; Metastatic Colorectal Cancer; Metastatic Hormone Refractory(Castration Resistant; androgen- Independent) Prostate Cancer;Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; RecurrentGlioblastoma Multiforme (GBM); Recurrent Malignant Glioma; Small-CellLung Cancer Rinucumab Placenta Growth Factor; Vascular Endothelial Wet(Neovascular/Exudative) Macular Degeneration Growth Factor RelatedProtein; PGF; Platelet Derived Growth Factor Receptor Beta; Beta TypePlatelet Derived Growth Factor Receptor; CD140 Antigen Like FamilyMember B; Platelet Derived Growth Factor Receptor 1; CD140b; PDGFRB; EC2.7.10.1; Vascular Endothelial Growth Factor A; Vascular PermeabilityFactor; VEGFA; Vascular Endothelial Growth Factor B; VEGF RelatedFactor; VEGFB Risankizumab Interleukin 23; IL23 Asthma; UlcerativeColitis; Ankylosing Spondylitis (Bekhterev's Disease); PsoriaticArthritis; Plaque Psoriasis (Psoriasis Vulgaris; Crohn's Disease(Regional Enteritis) Rituximab B Lymphocyte Antigen CD20; B LymphocyteB-Cell Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia SurfaceAntigen B1; Bp35; Leukocyte Surface (CLL); Diffuse Large B-CellLymphoma; Follicular Lymphoma; Antigen Lau 16; Membrane Spanning 4Non-Hodgkin Lymphoma; Microscopic Polyangiitis (MPA); Domains SubfamilyA Member 1; CD20; MS4A1 Granulomatosis with Polyangiitis (WegenerPolyangiitis); Rheumatoid Arthritis; Vasculitis; Nephrotic Syndrome;Pemphigus Vulgaris; Neuromyelitis Optice (Devic's Syndrome);Glomerulonephritis; Idiopathic Thrombocytopenic Purpura (ImmuneThrombocytopenic Purpura); Kidney Transplant Rejection; Liver TransplantRejection; Thrombotic Thrombocytopenic Purpura; Hemophilia A; LupusNephritis; Myasthenia Gravis; Sicca Syndrome (Sjogren); Systemic LupusErythematosus; Autoimmune Disease Rivabazumab, Pseudomonas aeruginosatype III secrection Pseudomonas aeruginosa infection Rivabazumab system;ttss pcrv protein pegol Robatumumab Insulin Like Growth Factor 1;Mechano Growth Colorectal Cancer; Ewing Sarcoma; Osteosarcoma; SolidFactor; Somatomedin C; IGF1 Tumor Roledumab Blood Group Rh(DPolypeptide; RHXIII; Rh Erythroblastosis Fetalis (Hemolytic Disease InNewborns) Polypeptide 2; Rhesus D Antigen; CD240D; RHD RomosozumabSclerostin; SOST Post Menopausal Osteoporosis; Osteopenia; BoneFracture; Osteoporosis Rontalizumab, Interferon Alpha/Beta Receptor I;Cytokine Systemic Lupus Erythematosus Rontalizuab Receptor Class IIMember I; Cytokine Receptor Family 2 Member I; Type I InterferonReceptor I; IFNAR1; Interferon Alpha/Beta Receptor 2; Interferon AlphaBinding Protein; Type I Interferon Receptor 2; IFNAR2; IFN-αRosmantuzumab R Spondin 3; Roof Plate Specific Spondin 3; Solid Tumor;Metastatic Colorectal Cancer; Lung Cancer; Protein With TSP Type IRepeat; Ovarian Cancer; Pancreatic Cancer Thrombospondin Type I DomainContaining Protein 2; RSPO3 Rovalpituzumab, Delta Like Protein 3;Drosophila Delta Graft Versus Host Disease (GVHD); Small-Cell LungCancer; Rovalpituzumab Homolog 3; DLL3 Prostate Cancer; GlioblastomaMultiforme (GBM); Melanoma; tesirine Pancreatic Cancer; Gastric Cancer;Small-Cell Lung Cancer; Medullary Thyroid Cancer; NeuroendocrineCarcinoma; Small- Cell Lung Cancer Rovelizumab Integrin Beta 2; CellSurface Adhesion Multiple Sclerosis; Hemorrhagic Shock; Ischemic Stroke;Glycoproteins LFA-1/CR3/p150; 95 Subunit Myocardial Infarction;Restenosis; Cerebral Vasospasm; Kidney Beta; Complement Receptor C3Subunit Beta; Transplant Rejection; Brain (Head) Trauma CD18; ITGB2Rozanolixizumab FCGRT; FCRN Receptor Myasthenia Gravis; IdiopathicThrombocytopenic Purpura (Immune Thrombocytopenic Purpura) RuplizumabCD40 Ligand; T Cell Antigen Gp39; TNF Related Glomerulonephritis; KidneyTransplant Rejection; Lupus Activation Protein; Tumor Necrosis FactorNephritis; Transplant Rejection Ligand Superfamily Member 5; CD154;CD40LG Sacituzumab, Tumor Associated Calcium Signal TransducerNeuromyelitis Optica (Devic's Syndrome); Breast Cancer; Lung Sacituzumab2; Cell Surface Glycoprotein Trop 2; Cancer; Ovarian Cancer;Glioblastoma Multiforme (GBM); govitecan Membrane Component Chromosome ISurface Kidney Cancer (Renal Cell Cancer); Non-Small Cell Lung Marker I;Pancreatic Carcinoma Marker Cancer; Esophageal Cancer; Epithelial Tumor;Colorectal Protein GA733-I; TACSTD2 Cancer; Cervical Cancer; GastricCancer; Bladder Cancer; Metastatic Breast Cancer; Small-Cell LungCancer; Endometrial Cancer; Colon Cancer; Follicular Thyroid Cancer;Head and Neck Cancer Squamous Cell Carcinoma; Hepatocellular Carcinoma;Hormone Refractory (Castration Resistant; androgen-Independent) ProstateCancer; Pancreatic Ductal Adenocarcinoma; Transitional Cell Cancer(Urothelial Cell Cancer) Samalizumab OX 2 Membrane Glycoprotein; MOX1;MOX2; Acute Myelocytic Leukemia (AML; Acute Myeloblastic MRC; CD200Leukemia); Refractory Acute Myeloid Leukemia; Relapsed Acute MyeloidLeukemia; Solid Tumor; B-Cell Chronic Lymphocytic Leukemia; MultipleMyeloma (Kahler Disease) Sapelizumab Interleukin 6 Receptor; IL6RRheumatoid Arthritis; Neuromyelitis Optica (Devic's Syndrome) SarilumabInterleukin 6 Receptor; IL6R Oligoarticular Idiopathic JuvenileArthritis; Polyarticular Juvenile Idiopathic Arthritis (PJIA);Systemic-Onset Juvenile Idiopathic Arthritis (Still Disease); AnkylosingSpondylitis (Bekhterev's Disease); Intermediate Uveitis; PosteriorUveitis; Uveitis; Rheumatoid Arthritis Satumomab, Insulin Receptor; IR;CD220; INSR; EC 2.7.10.1; Type 1 Diabetes (Juvenile Diabetes); Type 2Diabetes; Cancer Satumomab TAG-72 (Diagnosis) pendetide SecukinumabInterleukin 17; IL17; Interleukin 17A; Cytotoxic T AxialSpondyloarthritis; Psoriasis; Ankylosing Spondylitis LymphocyteAssociated Antigen B; CTLA8; (Bekhterev's Disease); Psoriatic Arthritis;Plaque Psoriasis IL17A (Psoriasis Vulgaris); Congenital Ichthyosis;Netherton Syndrome (Trichorrhexis Invaginata; Bamboo Hair); Systemic-Onset Juvenile Idiopathic Arthritis (Still Disease); Alopecia; AtopicDermatitis; Contact Dermatitis; Crohn's Disease (Regional Enteritis);Neutrophilia; Type I Diabetes (Juvenile Diabetes); Keratoconjunctivitissicca (Dry Eye); Relapsing Multiple Sclerosis (RMS); Relapsing RemittingMultiple Sclerosis (RRMS); Uveitis; Rheumatoid Arthritis; AsthmaSelicrelumab CD40; tumor necrosis factor receptor Solid Cancersuperfamily member 5; TNFRSF5 Senlizumab Tumor Necrosis Factor;Cachectin; TNF Alpha; Septic Shock; Crohn's Disease (Regional Enteritis)Tumor Necrosis Factor Ligand Superfamily Member 2; TNF a; TNFSeribantumab Receptor Tyrosine Protein Kinase ERBB 3; Bile Duct Cancer(Cholangiocarcinoma); Breast Cancer; Proto Oncogene Like Protein c ErbB3; Endometrial Cancer; Epithelial Ovarian Cancer; Fallopian TubeTyrosine Kinase Type Cell Surface Receptor Cancer; Metastatic BreastCancer; Ovarian Cancer; Peritoneal HER3; HER3; ERBB3; EC 2.7.10.1Cancer; Solid Tumor; Colorectal Cancer; Head and Neck Cancer SquamousCell Carcinoma; Non-Small Cell Lung Cancer Setoxaximab Shiga Toxin Type2; stx2 Escherichia coli Infections; Typical Hemolytic Bromic Syndrome(Shiga-Toxin Associated Hemolytic Uremic Syndrome) Sevirumab HumanCytomegalovirus Glycoprotein H; gH Cytomegalovirus (CMV) Retinitis;Cytomegalovirus (HHV-5) Infections Sibrotuzumab Prolyl EndopeptidaseFAP; 170 kDa Melanoma Metastatic Colorectal Cancer; Non-Small Cell LungCancer Membrane Bound Gelatinase; Dipeptidyl Peptidase FAP; IntegralMembrane Serine Protease; Fibroblast Activation Protein Alpha; GelatineDegradation Protease FAP; Seprase; FAP; EC 3.4.21.26; EC 3.4.14.5Sifalimumab Interferon Alpha; IFNA Systemic Lupus Erythematosus;Dermatomyositis; Polymyositis; Plaque Psoriasis (Psoriasis Vulgaris)Siltuximab Interleukin 6; B Cell Stimulatory Factor 2; B-CellNon-Hodgkin Lymphoma; Metastatic Hormone BSF2; CTL DifferentiationFactor; CDF; Refractory (Castration Resistant; androgen-Independent)Hybridoma Growth Factor; Interferon Beta 2; Prostate Cancer; MetastaticRenal Cell Carcinoma; IFNB2; IL6 Myelodysplastic Syndrome; RefractoryMultiple Myeloma; Relapsed Multiple Myeloma; Multiple Myeloma (KahlerDisease); Giant Lymph Node Hyperplasia (Castleman's Disease) SimtuzumabLysyl Oxidase Homolog 2; Lysyl Oxidase Like Idiopathic PulmonaryFibrosis; Adenocarcinoma; Metastatic Protein 2; Lysyl Oxidase RelatedProtein 2; Adenocarcinoma of The Pancreas; Metastatic Colorectal LysylOxidase Related Protein WS9-14; LOXL2; Cancer; Myelofibrosis;Post-Polycythemia Vera Myelofibrosis EC 1.4.3.13 (PPV-MF);Thrombocythemia Myelofibrosis; Liver Cirrhosis; Liver Fibrosis;Non-Alcoholic Steatohepatitis; Primary Sclerosing Cholangitis SiplizumabT Cell Surface Antigen CD2; Erythrocyte Leukemias; Natural Killer CellLymphomas; Kidney Disease; Receptor; LFA2; LFA3 Receptor; Rosette GraftVersus Host Disease (GVHD); Kidney Transplant Receptor; T Cell SurfaceAntigen T11/Leu 5; Rejection; Plaque Psoriasis (Psoriasis Vulgaris);Cutaneous T- CD2 Cell Lymphoma; Peripheral T-Cell Lymphomas (PTCL);T-Cell Lymphomas Sirukumab Interleukin 6; B Cell Stimulatory Factor 2;Rheumatoid Arthritis; Giant Cell Arteritis; Major Depressive BSF2; CTLDifferentiation Factor; CDF; Disorder; Polymyalgia Rheumatica; Asthma;Cutaneous Lupus Hybridoma Growth Factor; Interferon Beta 2;Erythematosus; Systemic Lupus Erythematosus; Lupus IFNB2; IL6 NephritisSofituzumab Mucin 16; Ovarian Cancer Related Tumor Ovarian Cancer;Fallopian Tube Cancer; Epithelial Ovarian vedotin Marker CA125; OvarianCarcinoma Antigen Cancer; Pancreatic Cancer; Peritoneal Cancer CA125;MUC16 Solanezumab Amyloid Beta Peptide; A beta P; Abeta; BetaAlzheimer's Disease; Dementia Associated With Alzheimer's AmyloidDisease Solitomab Epithelial Cell Adhesion Molecule; Adenocarcinoma OfThe Gastroesophageal Junction; Breast Adenocarcinoma Associated Antigen;Cell Cancer; Colorectal Cancer; Gastric Cancer; Hormone SurfaceGlycoprotein Trop 1; Epithelial Cell Refractory (Castration Resistant;androgen-Independent) Surface Antigen; Epithelial Glycoprotein 314;Prostate Cancer; Lung Adenocarcinoma; Ovarian Cancer; KS ¼ Antigen; KSA;Tumor Associated Small-Cell Lung Cancer; Solid Tumor Calcium SignalTransducer 1; CD326; EPCAM; T Cell Surface Glycoprotein CD3 EpsilonChain; T Cell Surface Antigen T3/Leu 4 Epsilon Chain; CD3E SonepcizumabSphingosine 1-Phosphate Receptor 1; Choroidal Neovascularization;Retinal Pigment Epithelial (RPE) Endothelial Differentiation G ProteinCoupled Detachment; Wet (Neovascular/Exudative) Macular Receptor 1;Sphingosine 1 Phosphate Receptor Degeneration; Renal Cell Carcinoma;Solid Tumor; Diabetic Edg 1; CD363; SIPRI Retinopathy; MultipleSclerosis; Colitis Sontuzumab Mucin 1; Breast Carcinoma AssociatedAntigen Advanced Malignancy; Breast Cancer DF3; Episialin; H23AG; KrebsVon Den Lungen 6; PEMT; Peanut Reactive Urinary Mucin; PolymorphicEpithelial Mucin; Tumor Associated Epithelial Membrane Antigen; TumorAssociated Mucin; CD227; MUC1 Stamulumab Growth/Differentiation Factor8; Myostatin; Muscular Dystrophy GDF8; MSTN Suptavumab RespiratorySyncytial Virus Fusion Protein; Respiratory Syncytial Virus (RSV)Infections RSV F Protein Suvizumab Human Immunodeficiency Virus Type 1;HIV-1 Human Immunodeficiency Virus (HIV) Infections (AIDS) envelopeglycoprotein gp120 third variable loop V3 Suvratoxumab Staphylococcusaureus Alpha Hemolysin; Staphylococcus aureus Infections; VentilatorAssociated Alpha Toxin; hly Pneumonia (VAP) Tabalumab Tumor NecrosisFactor Ligand Superfamily Relapsing Remitting Multiple Sclerosis (RRMS);End-Stage Member 13B; B Lymphocyte Stimulator; Kidney Disease (End-StageRenal Disease; ESRD); Rheumatoid Dendritic Cell Derived TNF LikeMolecule; TNF Arthritis; Systemic Lupus Erythematosus; Multiple Myelomaand APOL Related Leukocyte Expressed Ligand (Kahler Disease) RefractoryMultiple Myeloma; Relapsed 1; CD257; TNFSF13B Multiple MyelomaTacatuzumab, Alpha Fetoprotein Receptor; AFPR Liver Cancer Tacatuzumabtetraxetan Tadocizumab Integrin Alpha 2b; GPalpha IIb; Platelet CoronaryThrombosis; Cerebral Infarction (Brain Infarction) Membrane GlycoproteinIIb; CD41; ITGA2B Antagonist Talizumab Immunoglobulin E; IgE PeanutAllergy; allergy Tamtuvetmab Canis familiaris T cell Infectious Disease;Oncology Tanezumab Beta Nerve Growth Factor; Beta NGF; NGF ChronicPancreatitis Pain; Chronic Visceral Pain; Diabetic Neuropathic Pain;Neuropathic Pain; Cancer Pain; Chronic Pain; Low Back Pain;Osteoarthritis Pain; Interstitial Cystitis (Painful Bladder Syndrome)Tarextumab Neurogenic Locus Notch Homolog Protein 2; Small-Cell LungCancer; Solid Tumor; Metastatic Pancreatic NOTCH2; Neurogenic LocusNotch Homolog Cancer Protein 3; NOTCH3 Tavolixizumab Tumor NecrosisFactor Receptor Superfamily Solid Tumor; Head and Neck Cancer SquamousCell Carcinoma Member 4; ACT35 Antigen; TAX Transcriptionally ActivatedGlycoprotein I Receptor; OX40L Receptor; CD134; TNFRSF4 TefibazumabClumping Factor A; Fibrinogen Receptor A; Staphylococcus aureusInfections Fibrinogen Binding Protein A; clfA Telisotuzumab, HepatocyteGrowth Factor Receptor; Proto Solid Tumor Telisotuzuab Oncogene c Met;Tyrosine Protein Kinase Met; vedotin HGF/SF Receptor; Scatter FactorReceptor; MET; EC 2.7.10.1 Tenatumomab Tenascin; Cytotactin; GMEM; GP150-225; Breast Cancer; Lung Cancer; Ovarian Cancer; Colorectal GliomaAssociated Extracellular Matrix Cancer; B-Cell Non-Hodgkin Lymphoma;T-Cell Lymphomas Antigen; Hexabrachion; JI; Myotendinous Antigen;Neuronectin; Tenascin C; TNC Teneliximab Tumor Necrosis Factor ReceptorSuperfamily Kidney Transplant Rejection; Transplant Rejection Member 5;B Cell Surface Antigen CD40; Bp50; CDw40; CD40L Receptor; TNFRSF5; CD40Teplizumab T Cell Surface Glycoprotein CD3 Epsilon Psoriasis Chain; TCell Surface Antigen T3/Leu 4 Epsilon Chain; CD3E Teprotumumab InsulinLike Growth Factor 1 Receptor; CD221; Graves' Ophthalmopathy; DiabeticMacular Edema; Solid IGF1R; EC 2.7.10.1 Tumor; Breast Cancer; EwingSarcoma; Non-Small Cell Lung Cancer; Osteosarcoma; Rhabdomyosarcoma;Sarcomas; Synovial Sarcoma; Tesidolumab Complement C5; C3 and PZP LikeAlpha 2 Thrombotic Microangiopathy Paroxysmal Nocturnal MacroglobulinDomain Containing Protein 4; Hemoglobinuria Dry (Atrophic) MacularDegeneration; C5 Intermediate Uveitis; Posterior Uveitis; UveitisEnd-Stage Kidney Disease (End-Stage Renal Disease; ESRD) Wet(Neovascular/Exudative) Macular Degeneration Tezepelumab Thymic StromalLymphopoietin; TSLP Atopic Dermatitis; Cat Allergy; Allergic AsthmaThioMAb- CD79 chMA79b ThioMAb- CD79 huMA79b.v17 ThioMAb- CD79huMA79b.v18 ThioMAb- CD79 huMA79b.v28 Tigatuzumab, Tumor Necrosis FactorReceptor Superfamily Adenocarcinoma; Brenner Tumor; Carcinomas;Lymphoma; Igatuzuab Member 5; B Cell Surface Antigen CD40; MetastaticBreast Cancer; Metastatic Colorectal Cancer; Bp50; CDw40; CD40LReceptor; TNFRSF5; Metastatic Ovarian Cancer; Metastatic PancreaticCancer; CD40; TRAIL-R2 Non-Small Cell Lung Cancer; Transitional CellCarcinoma (Urothelial Cell Carcinoma); Hepatocellular CarcinomaTildrakizumab Interleukin 23 Subunit Alpha; Interleukin 23 AnkylosingSpondylitis (Bekhterev's Disease); Axial Subunit p19; IL23ASpondyloarthritis; Psoriatic Arthritis; Plaque Psoriasis (PsoriasisVulgaris) Timigutuzumab ERBB2; epidermal growth factor receptor 2;Breast Cancer; Adenocarcinoma Of The Gastroesophageal receptortyrosine-protein kinase Junction; Gastric Cancer; Metastatic BreastCancer Timolumab Membrane Primary Amine Oxidase; Copper PrimarySclerosing Cholangitis; Neurology; Plaque Psoriasis Amine Oxidase;Semicarbazide-Sensitive (Psoriasis Vulgaris); Rheumatoid Arthritis;Chronic Amine Oxidase; Vascular Adhesion Protein 1; ObstructivePulmonary Disease (COPD); Inflammatory Bowel HPA0; A0C3; EC 1.4.3.21Disease; Psoriasis; Rheumatoid Arthritis Tisotumab Tissue Factor; TFOvarian Cancer; Non-Small Cell Lung Cancer; Esophageal vedotin Cancer;Cervical Cancer; Bladder Cancer; Endometrial Cancer; Head and NeckCancer Squamous Cell Carcinoma; Hormone Refractory (CastrationResistant; androgen-Independent) Prostate Cancer; Pancreatic Cancer;Cancer Tocilizumab Interleukin 6 Receptor; IL6R Systemic Sclerosis(Scleroderma); Amyotrophic Lateral Sclerosis; Dermatomyositis;Polymyositis; Pulmonary Arterial Hypertension; Schnitzler Syndrome;B-Cell Chronic Lymphocytic Leukemia; Polymyalgia Rheumatica; Giant LymphNode Hyperplasia (Castleman's Disease); Ankylosing Spondylitis(Bekhterev's Disease); Metastatic Pancreatic Cancer; Giant CellArteritis; Polyarticular Juvenile Idiopathic Arthritis (PJIA); SystemicIdiopathic Juvenile Arthritis; Giant Lymph Node Hyperplasia (Castleman'sDisease); Rheumatoid Arthritis; Rheumatoid Arthritis; TakayasuArteritis; Vasculitis” Tomuzotuximab Epidermal Growth Factor Receptor;Proto Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Oncogenec ErbB 1; Receptor Tyrosine Protein Colorectal Cancer; Non-Small CellLung Cancer; Solid Tumor Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1Toralizumab CD40 Ligand; T Cell Antigen Gp39; TNF Related MultipleSclerosis; Crohn's Disease (Regional Enteritis); Activation Protein;Tumor Necrosis Factor Idiopathic Thrombocytopenic Purpura (Immune LigandSuperfamily Member 5; CD154; CD40LG Thrombocytopenic Purpura);Autoimmune Disorders; Psoriasis; Systemic Lupus ErythematosusTosatoxumab Staphylococcus aureus Alpha Hemolysin; Community AcquiredPneumonia; Hospital Acquired Pneumonia Alpha Toxin; hly (HAP); Sepsis;Ventilator Associated Pneumonia (VAP) Tositumomab B Lymphocyte AntigenCD20; B Lymphocyte B-Cell Non-Hodgkin Lymphoma; Follicular LymphomaSurface Antigen B1; Bp35; Leukocyte Surface Antigen Leu 16; MembraneSpanning 4 Domains Subfamily A Member 1; CD20; MS4A1 Tovetumab PlateletDerived Growth Factor Receptor Solid Tumor; Hepatocellular Carcinoma;Advanced Malignancy; Alpha; Alpha Type Platelet Derived GrowthGlioblastoma Multiforme (GBM); Non-Small Cell Lung Cancer; FactorReceptor; CD140 Antigen Like Family Member A; Platelet Derived GrowthFactor Receptor 2; CD140a; PDGFRA; EC 2.7.10.1 Antagonist TralokinumabInterleukin 13; IL13 Ulcerative Colitis; Idiopathic Pulmonary Fibrosis;Atopic Dermatitis; Asthma Trastuzumab, Receptor Tyrosine Protein KinaseERBB 2; Gastric Cancer; Metastatic Breast Cancer; Metastatic TrastuzumabMetastatic Lymph Node Gene 19 Protein; Proto Transitional (Urothelial)Tract Cancer; Pancreatic Cancer; duocarmazine, Oncogene Neu; ProtoOncogene C ErbB 2; Adenocarcinoma Of The Gastroesophageal Junction;Breast Trastuzumab Tyrosine Kinase Type Cell Surface Receptor Cancer;Gastric Cancer; Cancer emtansine, HER2; p185erbB2; HER2; CD340; ERBB2;rhuMab HER2, HER2/neu; EC 2.7.10.1 rhuMab HER2(9C1), Herceptin, TRC-105,TRC105 Endoglin; CD105; ENG Breast Cancer; Non-Small Cell Lung Cancer;Fallopian Tube Cancer; Epithelial Ovarian Cancer; Colorectal Cancer;Bladder Cancer; Metastatic Breast Cancer; Angiosarcoma; Choriocarcinoma(Gestational Trophoblastic Neoplasia); Hepatocellular Carcinoma; HormoneRefractory (Castration Resistant; androgen-Independent) Prostate Cancer;Metastatic Renal Cell Carcinoma; Myocardial Fibrosis; Peritoneal Cancer;Recurrent Glioblastoma Multiforme (GBM); Transitional Cell Carcinoma(Urothelial Cell Carcinoma); Wet (Neovascular/ Exudative) MacularDegeneration Tregalizumab T Cell Surface Glycoprotein CD4; T CellMultiple Sclerosis; Plaque Psoriasis (Psoriasis Vulgaris); SurfaceAntigen T4/Leu 3; CD4 Activator Rheumatoid Arthritis Tremelimumab,Cytotoxic T Lymphocyte Protein 4; Cytotoxic T Non-Small Cell LungCancer; Adenocarcinoma Of The Ticiliuab, Lymphocyte Associated Antigen4; CD152; Gastroesophageal Junction; Epithelial Ovarian Cancer;Ticilimumab CTLA4; CTLA-4 Fallopian Tube Cancer; Gastric Cancer;Hepatocellular Carcinoma; Metastatic Breast Cancer; Peritoneal Cancer;Human Immunodeficiency Virus (HIV) Infections (AIDS); Bladder Cancer;Colorectal Cancer; Gastrointestinal Tract Cancer; Prostate Cancer; RenalCell Carcinoma; Malignant Pleural Mesothelioma; Metastatic Melanoma;Metastatic Pancreatic Cancer Trevogrumab Growth/Differentiation Factor8; Myostatin; Sarcopenia GDF8; MSTN Tucotuzumab, Epithelial CellAdhesion Molecule; Ovarian Cancer; Prostate Cancer; Renal CellCarcinoma; Non- Tucotuzumab Adenocarcinoma Associated Antigen; CellSmall Cell Lung Cancer; Colorectal Cancer; Small-Cell Lung celmoleukinSurface Glycoprotein Trop 1; Epithelial Cell Cancer; Cancer SurfaceAntigen; Epithelial Glycoprotein 314; KS ¼ Antigen; KSA; TumorAssociated Calcium Signal Transducer 1; CD326; EPCAM; EpCAM TuvirumabHepatitis B Virus Surface Antigen; HBsAg Hepatitis B Ublituximab BLymphocyte Antigen CD20; B Lymphocyte Chronic Lymphocytic Leukemia(CLL); Relapsed Chronic Surface Antigen B1; Bp35; Leukocyte SurfaceLymphocytic Leukemia (CLL); B-Cell Non-Hodgkin Lymphoma; Antigen Leu 16;Membrane Spanning 4 Mantle Cell Lymphoma; Neuromyelitis Optica (DovesDomains Subfamily A Member 1; CD20; MS4A1 Syndrome); Refractory ChronicLymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL)Ulocuplumab C—X—C Chemokine Receptor Type 4; FB22; Acute MyelocyticLeukemia (AML; Acute Myeloblestic Fusin; HM89; LCR1; Leukocyte DerivedSeven Leukemia); Refractory Multiple Myeloma; Relapsed MultipleTransmembrane Domain Receptor; Myeloma; Diffuse Large B-Cell Lymphoma;Follicular Lipopolysaccharide Associated Protein 3; Lymphoma; MetastaticPancreatic Cancer; Refractory Acute Stromal Cell Derived Factor 1Receptor; Myeloid Leukemia; Refractory Chronic Lymphocytic LeukemiaNPYRL; CD184; CXCR4 (CLL); Relapsed Acute Myeloid Leukemia; RelapsedChronic Lymphocytic Leukemia (CLL); Small-Cell Lung Cancer UrelumabTumor Necrosis Factor Receptor Superfamily Diffuse Large B-CellLymphoma; Head and Neck Cancer Member 9; 4-IBB Ligand Receptor; T CellSquamous Cell Carcinoma; Metastatic Melanoma; Non-Small Antigen 4-IBBHumolog; T Cell Antigen ILA; Cell Lung Cancer; Follicular Lymphoma;Gliosarcoma; CD137; TNFRSF9 Metastatic Colorectal Cancer; RecurrentGlioblastoma Multiforme (GBM); Chronic Lymphocytic Leukemia (CLL);Lymphoma; Refractory Chronic Lymphocytic Leukemia (CLL); RelapsedChronic Lymphocytic Leukemia (CLL) Urtoxazumab Shiga Toxin Type 2; stx2Escherichia coli Infections Ustekinumab Interleukin 12 Subunit Beta;Cytotoxic Ulcerative Colitis; Axial Spondyloarthritis; Systemic LupusLymphocyte Maturation Factor 40 kDa Erythematosus; Type I Diabetes(Juvenile Diabetes); Crohn's Subunit; CLMF p40; IL12 Subunit p40 NK CellDisease (Regional Enteritis); Relapsing Remitting Multiple StimulatoryFactor Chain 2; IL12B Sclerosis (RRMS); Hidradenitis Suppurativa; PlaquePsoriasis (Psoriasis Vulgaris); Psoriasis; Rheumatoid Arthritis; PrimaryBiliary Cirrhosis; Atopic Dermatitis; Sarcoidosis; Psoriatic Arthritis;Plaque Psoriasis (Psoriasis Vulgaris); Crohn's Disease (RegionalEnteritis)” utomilumab Tumor Necrosis Factor Receptor SuperfamilyAnaplastic Thyroid Cancer; Bladder Cancer; Cervical Cancer; Member 9;4-IBB Ligand Receptor; T Cell Diffuse Large B-Cell Lymphoma; FollicularLymphoma; Gastric Antigen 4-IBB Humping; T Cell Antigen ILA; Cancer;Metastatic Hepatocellular Carcinoma (HCC); Ovarian CD137; TNFRSF9Cancer; Pancreatic Cancer; Renal Cell Carcinoma; Sarcomas; Thymoma(Thymic Epithelial Tumor); Colorectal Cancer; Head and Neck CancerSquamous Cell Carcinoma; Metastatic Breast Cancer; Metastatic Melanoma;Non-Small Cell Lung Cancer; Small-Cell Lung Cancer Vadastuximab, MyeloidCell Surface Antigen CD33; Sialic Acid Acute Myelocytic Leukemia (AML;Acute Myeloblestic Vadastuximab Binding Ig Like Lectin 3; gp67; CD33Leukemia); Myelodysplastic Syndrome; Refractory Acute talirine MyeloidLeukemia; Relapsed Acute Myeloid Leukemia Vandortuzumab,Metalloreductase STEAP1; Six Transmembrane Metastatic Hormone Refractory(Castration Resistant; Vandortuzumab Epithelial Antigen Of The Prostate1; STEAP1; androgen-Independent) Prostate Cancer vedotin EC 1.16.1.Vantictumab Frizzled 7; hFz7; FzE3; FZD7 Metastatic Breast Cancer;Non-Small Cell Lung Cancer; Pancreatic Ductal Adenocarcinoma VanucizumabAngiopoietin 2; Ang 2; ANGPT2; Vascular Metastatic Colorectal Cancer;Epithelial Ovarian Cancer; Endothelial Growth Factor A; VascularFallopian Tube Cancer; Peritoneal Cancer; Solid Tumor PermeabilityFactor; VEGFA Vapaliximab Membrane Primary Amine Oxidase; CopperInflammation Amine Oxidase; Semicarbazide-Sensitive Amine Oxidase;Vascular Adhesion Protein 1; HPAD; ADC3; EC 1.4.3.21 Varisacumab,Vascular Endothelial Growth Factor A; Metastatic Cancer; Oncology ApaginVascular Permeability Factor; VEGFA Varlilumab CD27 Antigen; CD27LReceptor; T Cell Bladder Cancer; Breast Cancer; Colorectal Cancer;Fallopian Activation Antigen CD27; Tumor Necrosis Tube Cancer;Glioblastoma Multiforme (GBM); Head and Neck Factor Receptor SuperfamilyMember 7; T14; Cancer Squamous Cell Carcinoma; Metastatic Melanoma; Non-TNFRSF7; CD27 Small Cell Lung Cancer; Ovarian Cancer; Renal CellCarcinoma; Colorectal Cancer; Hormone Refractory (Castration Resistant;androgen-Independent) Prostate Cancer; Leukemias; Lymphoma; MetastaticMelanoma; Non-Small Cell Lung Cancer; Ovarian Cancer; Renal CellCarcinoma Vatelizumab Integrin Alpha 2; CD49 Antigen Like Family Crohn'sDisease (Regional Enteritis); Ulcerative Colitis; Member B; CollagenReceptor; Platelet Relapsing Remitting Multiple Sclerosis (RRMS)Membrane Glycoprotein 1a; VLA 2 Subunit Alpha; CD49b; ITGA2 VedolizumabIntegrin Alpha 4; CD49 Antigen Like Family Primary SclerosingCholangitis; Celiac Disease; Graft Versus Member D; VLA4 Subunit Alpha;CD49d; ITGA4; Host Disease (GVHD); Human Immunodeficiency Virus (HIV)Integrin Beta 7; Gut Homing Receptor Beta Infections (AIDS); Melanoma;Crohn's Disease (Regional Subunit; ITGB7 Enteritis); Ulcerative Colitis”Veltuzumab B Lymphocyte Antigen CD20; B Lymphocyte IdiopathicThrombocytopenic Purpura (Immune Surface Antigen B1; Bp35; LeukocyteSurface Thrombocytopenic Purpura); Non-Hodgkin Lymphoma; Antigen Leu 16;Membrane Spanning 4 Pemphigus Vulgaris; Acute Lymphocytic Leukemia (ALL;Acute Domains Subfamily A Member 1; CD20; MS4A1 Lymphoblastic Leukemia);Chronic Lymphocytic Leukemia (CLL); Follicular Lymphoma; Systemic LupusErythematosus; Rheumatoid Arthritis Vepalimomab Membrane Primary AmineOxidase; Copper Contact Dermatitis; Ulcerative Colitis; Psoriasis AmineOxidase; Semicarbazide-Sensitive Amine Oxidase; Vascular AdhesionProtein 1; HPAD; ADC3; EC 1.4.3.21 Vesencumab Neuropilin 1; VascularEndothelial Cell Growth Solid Tumor Factor 165 Receptor; CD304; NRP1Visilizumab T Cell Surface Glycoprotein CD3 Epsilon Graft Versus HostDisease (GVHD); Crohn's Disease (Regional Chain; T Cell Surface AntigenT3/Leu 4 Epsilon Enteritis); Ulcerative Colitis Chain; CD3EVobarilizumab Interleukin 6 Receptor; IL6R Rheumatoid Arthritis;Systemic Lupus Erythematosus Volociximab Integrin Alpha 5; CD49 AntigenLike Family Age Related Macular Degeneration; Metastatic Melanoma;Member E; Fibronectin Receptor Subunit Metastatic Pancreatic Cancer;Non-Small Cell Lung Cancer; Alpha; lntegrin Alpha F; VLA 5; CD49e;ITGA5; Ovarian Cancer; Peritoneal Tumor; Renal Cell Carcinoma IntegrinBeta 1; Fibronectin Receptor Subunit Beta; Glycoprotein lia; VLA 4Subunit Beta; CD29; ITGB1 Vorsetuzumab, CD70 Antigen; CD27 Ligand; TumorNecrosis Autoimmune Disorders; Cancer Vorsetuzumab Factor LigandSuperfamily Member 7; CD70 mafodotin Vunakizumab Interleukin 17A;Cytotoxic T Lymphocyte Psoriasis Associated Antigen B; CTLA8; IL17AXentuzumab Insulin Like Growth Factor I; Mechano Growth Non-Small CellLung Cancer; Metastatic Breast Cancer; Solid Factor; Somatomedin C;IGF1; Insulin Like Tumor; Metastatic Hormone Refractory (CastrationResistant, Growth Factor II; Somatomedin A; T3M II androgen-Independent)Prostate Cancer Derived Growth Factor; IGF2 Zalutumumab Epidermal GrowthFactor Receptor; Proto Non-Small Cell Lung Cancer; Squamous CellCarcinoma; Oncogene c ErbB 1; Receptor Tyrosine Protein ColorectalCancer; Head and Neck Cancer; Metastatic Cancer Kinase erbB 1; HER1;ERBB1; EGFR; EC 2.7.10.1 Zanolimumab T Cell Surface Glycoprotein CD4; TCell Psoriasis; Rheumatoid Arthritis; Cutaneous T-Cell Lymphoma; SurfaceAntigen T4/Leu 3; CD4 Sezary Syndrome; Mycosis Fungoides; T-CellLymphomas Zatuximab Epidermal Growth Factor Receptor; Proto GlioblastomaMultiforme (GBM); Metastatic Colorectal Cancer; Oncogene c ErbB 1;Receptor Tyrosine Protein Recurrent Head and Neck Cancer Squamous CellCarcinoma; Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 SquamousNon-Small Cell Lung Cancer; Esophageal Cancer; Solid Tumor

Preferably, the RNA according to the present invention, the combinationof RNA's according to the present invention, the composition accordingto the present invention, the vaccine according to the presentinvention, or the pharmaceutically active component of the kit accordingto the present invention is administered by injection, preferably byneedle-less injection, more preferably by jet injection.

It is also preferred that the treatment of the diseases/disorders asdescribed above (therapy or prophylaxis) by using the RNA according tothe present invention, the combination of RNA's according to the presentinvention,the composition according to the present invention, thevaccine according to the present invention, or the kit according to thepresent invention comprises the administration of a furtherpharmaceutical compound. Such a further pharmaceutical compound ispreferably a chemotherapeutic agent or a kinase inhibitor, in particularin the context of treatment of cancer. Moreover, in particular in thecontext of cancer treatment, the treatment or prophylaxis as describedherein may preferably further comprise radiation therapy.

It is also preferred that the treatment of the diseases/disorders asdescribed above (therapy or prophylaxis) by using the RNA according tothe present invention, the combination of RNA's according to the presentinvention, the composition according to the present invention, thevaccine according to the present invention, or the kit according to thepresent invention further comprises the administration of at least onemodulator of an inhibitory and/or a stimulatory checkpoint molecule,such as an inhibitor of an inhibitory checkpoint molecule, preferably aninhibitor of CTLA-4 or of the PD-1 pathway.

The present invention also provides methods of treating or preventingthe diseases and/or disorders as described above by administering to asubject in need thereof a (pharmaceutically) effective amount of theRNA, the combination of RNA's, the pharmaceutical composition or thevaccine according to the invention. Such a method typically comprises anoptional first step of preparing the RNA, the combination of RNA's, thecomposition or the vaccine of the present invention, and a second step,comprising administering (a pharmaceutically effective amount of) saidcomposition or vaccine to a patient/subject in need thereof. A subjectin need thereof will preferably be a mammal. In the context of thepresent invention, the mammal is preferably selected from the groupcomprising, without being limited thereto, e.g. goat, cattle, swine,dog, cat, donkey, monkey, ape, a rodent such as a mouse, hamster, rabbitand, particularly, human, wherein the mammal typically suffers from thediseases and/or disorders as described above. Preferably, thedisease/disorder is a cancer, a cardiovascular disease, an infectiousdisease, an autoimmune disease, a virus disease or a monogeneticdisease.

In such a method according to the present invention also a combinationof RNA's as described herein may be used, whereby the at least two RNA'sof such a combination may be administered separately or in the samecomposition as described above. For example, in separate administrationthe at least two distinct RNA's may be administered at about the sametime or consecutively via the same or different routes of administrationas described above.

The subject receiving the RNA, the combination of RNA's, thepharmaceutical composition or the vaccine according to the inventionmay, for example, be a patient with cancer, preferably as definedherein, or a related condition, receiving chemotherapy (e.g. first-lineor second-line chemotherapy), radiotherapy, chemoradiation (combinationof chemotherapy and radiotherapy), tyrosine kinase inhibitors (e.g. EGFRtyrosine kinase inhibitors), antibody therapy and/or inhibitory and/orstimulatory checkpoint molecules (e.g. CTLA4 inhibitors, PD1 pathwayinhibitors), or a patient, who has achieved partial response or stabledisease after having received one or more of the treatments specifiedabove. Support of the treatment or prophylaxis of cancer may be alsoenvisaged in any of the other embodiments defined herein. Accordingly,any use of the RNA, the (pharmaceutical) composition or the vaccineaccording to the invention in co-therapy with any other approach,preferably one or more of the above therapeutic approaches, inparticular in combination with surgery, radiation therapy, chemotherapy,chemoradiation, and/or treatment with kinase inhibitors, modulators ofinhibitory and/or stimulatory checkpoint molecules or antibodies iswithin the scope of the present invention. In particular, modulators ofinhibitory and/or stimulatory checkpoint molecules used for combinationwith the RNA, the vaccine or the (pharmaceutical) composition accordingto the invention may be encoded by a nucleic acid, preferably an RNA andmost preferably by an mRNA.

For administration, preferably any of the administration routes may beused as defined herein. In particular, an administration route is used,which is suitable for treating or preventing any of the disorders and/ordiseases as described herein. Administration of the composition and/orthe vaccine according to the invention may then occur prior, concurrentand/or subsequent to administering another composition and/or vaccine asdefined herein, which may—in addition—contain another RNA or combinationof RNAs encoding different fragments of the same antibody or differentantibodies, wherein each antibody encoded by the RNA according to theinvention is preferably suitable for the treatment or prophylaxis of anyof the disorders and/or diseases as described herein. In this context, atreatment as defined herein may also comprise the modulation of adisease associated to the of the disorders and/or diseases as describedherein.

According to a preferred embodiment of this aspect of the invention, the(pharmaceutical) composition or the vaccine according to the inventionis administered by injection. Any suitable injection technique known inthe art may be employed. Preferably, the inventive composition isadministered by injection, preferably by needle-less injection, forexample by jet-injection.

In one embodiment, the inventive composition comprises at least two,three, four, five, six, seven, eight, nine, ten, eleven, twelve or moreRNAs as defined herein, each of which is preferably injected separately,preferably by needle-less injection. Alternatively, the inventivecomposition comprises at least two, three, four, five, six, seven,eight, nine, ten, eleven, twelve or more RNAs, wherein the at least two,three, four, five, six, seven, eight, nine, ten, eleven, twelve or moreRNAs are administered, preferably by injection as defined herein, as amixture.

The (passive) immunization protocol for the immunization of a subjecttypically comprises a series of single doses or dosages of the(pharmaceutical) composition or the vaccine according to the invention.A single dosage, as used herein, refers to the initial/first dose, asecond dose or any further doses, respectively. In this context, eachsingle dosage preferably comprises the administration of RNA encodingthe same antibody or the same combination of antibodies as definedherein, wherein the interval between the administration of two singledosages can vary from at least one day, preferably 2, 3, 4, 5, 6 or 7days, to at least one week, preferably 2, 3, 4, 5, 6, 7 or 8 weeks. Theintervals between single dosages may be constant or vary over the courseof the immunization protocol, e.g. the intervals may be shorter in thebeginning and longer towards the end of the protocol. Depending on thetotal number of single dosages and the interval between single dosages,the immunization protocol may extend over a period of time, whichpreferably lasts at least one week, more preferably several weeks (e.g.2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 weeks), even more preferablyseveral months (e.g. 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 18 or 24 months).Each single dosage preferably encompasses the administration of an RNAencoding an antibody, preferably of a combination of at least two,three, four, five, six, seven, eight, nine, ten, eleven, twelve or moreantibodies as defined herein and may involve at least one, preferably 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 injections. In some cases, thecomposition or the vaccine according to the invention is administered asa single dosage typically in one injection. In the case, where thevaccine according to the invention comprises separate RNA formulationsencoding distinct antibody fragments or distinct antibodies as definedherein, the minimum number of injections carried out during theadministration of a single dosage may correspond to the number ofseparate components of the vaccine. In certain embodiments, theadministration of a single dosage may encompass more than one injectionfor each component of the vaccine (e.g. a specific RNA formulationcomprising an RNA encoding, for instance, one antibody as definedherein). For example, parts of the total volume of an individualcomponent of the vaccine may be injected into different body parts, thusinvolving more than one injection. In a more specific example, a singledosage of a vaccine comprising four separate RNA formulations, each ofwhich is administered in two different body parts, comprises eightinjections. Typically, a single dosage comprises all injections requiredto administer all components of the vaccine, wherein a single componentmay be involve more than one injection as outlined above. In the case,where the administration of a single dosage of the vaccine according tothe invention encompasses more than one injection, the injection arecarried out essentially simultaneously or concurrently, i.e. typicallyin a time-staggered fashion within the time-frame that is required forthe practitioner to carry out the single injection steps, one after theother. The administration of a single dosage therefore preferablyextends over a time period of several minutes, e.g. 2, 3, 4, 5, 10, 15,30 or 60 minutes.

Administration of the RNA as defined herein, the (pharmaceutical)composition or the vaccine according to the invention may be carried outin a time staggered treatment. A time staggered treatment may be e.g.administration of the RNA, the composition or the vaccine prior,concurrent and/or subsequent to a conventional therapy of any of thedisorders and/or diseases as described herein, e.g. by administration ofthe RNA, the composition or the vaccine prior, concurrent and/orsubsequent to a therapy or an administration of a therapeutic suitablefor the treatment or prophylaxis of any of the disorders and/or diseasesas described herein. Such time staggered treatment may be carried outusing e.g. a kit, preferably a kit of parts as defined herein.

Time staggered treatment may additionally or alternatively also comprisean administration of the RNA as defined herein, the (pharmaceutical)composition or the vaccine according to the invention in a form, whereinthe RNA encoding an antibody as defined herein or a fragment or variantthereof, preferably forming part of the composition or the vaccine, isadministered parallel, prior or subsequent to another RNA encoding anantibody as defined above, preferably forming part of the same inventivecomposition or vaccine. Preferably, the administration (of all RNAs)occurs within an hour, more preferably within 30 minutes, even morepreferably within 15, 10, 5, 4, 3, or 2 minutes or even within 1 minute.Such time staggered treatment may be carried out using e.g. a kit,preferably a kit of parts as defined herein.

In a preferred embodiment, the pharmaceutical composition or the vaccineof the present invention is administered repeatedly, wherein eachadministration preferably comprises individual administration of the atleast one mRNA of the inventive composition or vaccine. At each timepoint of administration, the at least one mRNA may be administered morethan once (e.g. 2 or 3 times). In a particularly preferred embodiment ofthe invention, at least two, three, four, five, six or more RNAs (eachencoding a distinct one of the antibodies as defined herein) areadministered at each time point, wherein each RNA is administered twiceby injection, distributed over the four limbs.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 illustrates the structure of an IgG antibody. IgG antibodies arebuilt up from in each case two identical light and two heavy proteinchains which are bonded to one another via disulfide bridges. The lightchain comprises the N-terminal variable domain V_(L) and the C-terminalconstant domain C_(L). The heavy chain of an IgG antibody can be dividedinto an N-terminal variable domain V_(H) and three constant domainsC_(H)1, C_(H)2 and C_(H)3.

FIG. 2 shows the gene cluster for the light and the heavy chains of anantibody:

-   -   (A): Gene cluster for the light chain κ.    -   (B): Gene cluster for the light chain λ.    -   (C): and (D): Gene cluster for the heavy chain.    -   In this context, the variable region of a heavy chain is        composed of three different gene segments. In addition to the V        and J segments, additional D segments are also found here. The        V_(H), D_(H) and J_(H) segments can likewise be combined with        one another virtually as desired to form the variable region of        the heavy chain.

FIG. 3 illustrates in the form of a diagram the differences in the lightand heavy chains of murine (i.e. obtained in the mouse host organism),chimeric, humanized and human antibodies.

FIG. 4 shows an overview of the structure of various antibody fragments.The constituents of the antibody fragments are shown on a dark greybackground.

FIG. 5 shows various variants of antibodies and antibody fragments inFIGS. 5A, 5B and 5C:

-   -   (A) shows a diagram of an IgG antibody of two light and two        heavy chains.    -   (B) shows an Fab fragments from the variable and a constant        domain in each case of a light and a heavy chain. The two chains        are bonded to one another via a disulfide bridge.    -   (C) shows an scFv fragment from the variable domain of the light        and the heavy chain, which are bonded to one another via an        artificial polypeptide linker.

FIG. 6 shows a presentation of an exemplified antibody-coding (modified)RNA according to

-   -   the invention as an expression construct. In this:    -   V_(H)=variable domain of the heavy chain;    -   C_(H)=constant domain of the heavy chain;    -   V_(L)=variable domain of the light chain;    -   C_(L)=constant domain of the light chain;    -   SIRES=internal ribosomal entry site (IRES, superIRES)    -   muag=mutated form of the 3′ UTR of the alpha-globin gene; and    -   A70C30=polyA-polyC tail.

FIG. 7 shows a diagram of the detection of an antibody coded by an RNAaccording to the invention by means of ELISA on the example of theantigen Her2.

FIG. 8 shows the wild-type DNA sequence of the heavy chain of theantibody rituximab (=Rituxan, MabThera) (wild-type: GC content: 56.5%,length: 1,344) (SEQ ID NO: 61161).

FIG. 9 shows a GC-optimized DNA sequence of the heavy chain of theantibody rituximab (=Rituxan, MabThera) (GC content: 65.9%, length:1,344) (SEQ ID NO: 61162).

FIG. 10 shows the wild-type DNA sequence of the light chain of theantibody rituximab (=Rituxan, MabThera) (wild-type: GC content: 58.5%,length: 633) (SEQ ID NO: 61163).

FIG. 11 shows a GC-optimized DNA sequence of the light chain of theantibody rituximab (=Rituxan, MabThera) (GC content: 67.2%, length: 633)(SEQ ID NO: 61164).

FIG. 12 shows the total construct of a GC-optimized DNA sequence of theantibody rituximab (=Rituxan, MabThera) with the light and heavy chains(SEQ ID NO: 61165). The total construct contains the following sequencesand cleavage sites (see also alternative cleavage sites of FIG. 25 , SEQID NO: 61209):

AAGCTT HindIII

CATCATCATCATCATCAT His tag Signal peptide, HLA-A*0201: GC-richATGGCCGTGATGGCGCCGCGGACCCTGGTCCTCCTGCTGAGCGGCGCCCTCGCCCTGACGCAGACCTGGGCCGGG.

The coding region of the heavy chain sequence starts with the signalpeptide as given above (italic). This region is G/C enriched as well.The subsequent sequence starting with CAG represents the actual antibodycoding sequence (see FIG. 9 ) for the heavy chain, which ends with AAGand is followed by the above described His tag sequence. Finally, theopen reading frame for the heavy chain ends with the stop codon TGA (

). The coding region for the light chain sequence starts 3′ upstreamwith the signal peptide's ATG as given above followed by the lightchain's coding region for the light chain starting with CAG running tothe stop codon TGA (

) (see FIG. 11 ). Both coding regions for the light and the heavy chainare separated by an IRES element (

) The inventive RNA coded by the construct given in FIG. 12 may or maynot contain a (His) tag sequence and may contain a signal peptidesequence different from the above peptide sequence or may even have nosignal peptide sequence. Accordingly, the inventive RNA moleculecontains preferably the coding region (with or without a signal peptidesequence at its beginning) of the heavy and/or the light chain (e.g. asshown in FIG. 12 ), preferably in combination with at least oneribosomal entry site.

FIG. 13 shows the wild-type DNA sequence of the heavy chain of theantibody cetuximab (=Erbitux) (wild-type: GC content: 56.8%, length:1,359) (SEQ ID NO: 61166).

FIG. 14 shows a GC-optimized DNA sequence of the heavy chain of theantibody cetuximab (=Erbitux) (GC content: 65.9%, length: 1,359) (SEQ IDNO: 61167).

FIG. 15 shows the wild-type DNA sequence of the light chain of theantibody cetuximab (=Erbitux) (wild-type: GC content: 58.2%, length:642) (SEQ ID NO: 61168).

FIG. 16 shows a GC-optimized DNA sequence of the light chain of theantibody cetuximab (=Erbitux) (GC content: 65.7%, length: 642) (SEQ IDNO: 61169).

FIG. 17 shows the total construct of a GC-optimized DNA sequence of theantibody cetuximab (=Erbitux) with the light and heavy chains (SEQ IDNO: 61170). The total construct contains the following sequences andcleavage sites (see also alternative cleavage sites of FIG. 26 , SEQ IDNo 61210):

AAGCTT HindIII

CATCATCATCATCATCAT His tag Signal peptide, HLA-A*0201: GC-richATGGCCGTGATGGCGCCGCGGACCCTGGTCCTCCTGCTGAGCGGCGCCCTCGCCCTGACGCAGACCTGGGCCGGG.

The coding region of the heavy chain sequence starts with the signalpeptide as given above (italic). This region is G/C enriched as well.The subsequent sequence starting with CAG represents the actual antibodycoding sequence (see FIG. 14 ) for the heavy chain, which ends with AAGand is followed by the above described His tag sequence. Finally, theopen reading frame for the heavy chain ends with the stop codon TGA (

). The coding region for the light chain sequence starts 3′ upstreamwith the signal peptide's ATG as given above followed by the lightchain's coding region for the light chain starting with GAC running tothe stop codon TGA (

) (see FIG. 16 ). Both coding regions for the light and the heavy chainare separated by an IRES element (

). The inventive RNA coded by the construct given in FIG. 17 may or maynot contain a (His) tag sequence and may contain a signal peptidesequence different from the above peptide sequence or may even have nosignal peptide sequence. Accordingly, the inventive RNA moleculecontains preferably the coding region (with or without a signal peptidesequence at its beginning) of the heavy and/or the light chain (e.g. asshown in FIG. 17 ), preferably in combination with at least oneribosomal entry site.

FIG. 18 shows the wild-type DNA sequence of the heavy chain of theantibody trastuzumab (=Herceptin) (wild-type: GC content: 57.8%, length:1,356) (SEQ ID NO: 61171).

FIG. 19 shows a GC-optimized DNA sequence of the heavy chain of theantibody trastuzumab (=Herceptin) (GC content: 67.0%, length: 1,356)(SEQ ID NO: 61172).

FIG. 20 shows the wild-type DNA sequence of the light chain of theantibody trastuzumab (=Herceptin) (wild-type: GC content: 56.9%, length:645) (SEQ ID NO: 61173).

FIG. 21 shows a GC-optimized DNA sequence of the light chain of theantibody trastuzumab (=Herceptin) (GC content: 66.4%, length: 645) (SEQID NO: 61174).

FIG. 22 shows a total construct of the GC-optimized DNA sequence of theantibody trastuzumab (=Herceptin) with the light and heavy chains (SEQID NO: 61175). The total construct contains the following sequences andcleavage sites (see also alternative cleavage sites of FIG. 27 , SEQ IDNO: 61211):

AAGCTT HindIII

CATCATCATCATCATCAT His tag Signal peptide, HLA-A*0201: GC-richATGGCCGTGATGGCGCCGCGGACCCTGGTCCTCCTGCTGAGCGGCGCCCTCGCCCTGACGCAGACCTGGGCCGGG.

The coding region of the heavy chain sequence starts with the signalpeptide as given above (italic). This region is G/C enriched as well.The subsequent sequence starting with GAG represents the actual antibodycoding sequence (see FIG. 19 ) for the heavy chain, which ends with AAGand is followed by the above described His tag sequence. Finally, theopen reading frame for the heavy chain ends with the stop codon TGA (

). The coding region for the light chain sequence starts 3′ upstreamwith the signal peptide's ATG as given above followed by the lightchain's coding region for the light chain starting with GAC running tothe stop codon TGA (

) (see FIG. 21 ). Both coding regions for the light and the heavy chainare separated by an IRES element (

). The inventive RNA coded by the construct given in FIG. 22 may or maynot contain a (His) tag sequence and may contain a signal peptidesequence different from the above peptide sequence or may even have nosignal peptide sequence. Accordingly, the inventive RNA moleculecontains preferably the coding region (with or without a signal peptidesequence at its beginning) of the heavy and/or the light chain (e.g. asshown in FIG. 22 ), preferably in combination with at least oneribosomal entry site.

FIG. 23 shows for Example 1 RNA-mediated antibody expression in cellculture. CHO or BHK cells were transfected with 20 μg ofantibody-encoding mRNA according to the invention which was produced(RNA, G/C enriched, see above) or mock-transfected. 24 hours aftertransfection protein synthesis was analysed by Western blotting of celllysates. Cells harboured about 0.5 μg of protein as assessed by WesternBlot analysis. Each lane represents 10% of total lysate. Humanisedantibodies served as control and for a rough estimate of protein levels.The detection antibody recognises both heavy and light chains; moreover,it shows some unspecific staining with cell lysates (three distinctbands migrating much slower than those of the antibodies). A comparisonwith control antibodies clearly demonstrates that heavy and light chainswere produced in equal amounts.

FIG. 24 shows for Example 1 that RNA-mediated antibody expression givesrise to a functional protein (antibody). Functional antibody formationwas addressed by FACS staining of antigen-expressing target cells. Inorder to examine the production of functional antibodies, cell culturesupernatants of RNA-transfected (20 μg of Ab-RNA as defined above inExample 1) cells were collected after 48 to 96 hours. About 8% of totalsupernatant was used to stain target cells expressing the respectiveantigen. Humanised antibodies served as control and for a rough estimateof protein levels. Primary antibody used for cell staining: a) humanisedantibody; b) none; c,d) supernatant from RNA-transfected cellsexpressing the respective antibody; e) supernatant from mock-transfectedCHO cells. Calculations on the basis of the analysis shown in FIG. 24reveal that cells secreted more than 12-15 μg of functional antibodywithin 48-96 hours. Accordingly, the present invention proves that RNAencoding antibodies may enter into cell, may be expressed within thecell and considerable amounts of RNA encoded antibodies are thensecreted by the cell into the surrounding medium/extracellular space.Cell transfection in vivo or in vitro by the inventive RNA may thereforebe used to provide antibodies acting e.g. therapeutically in theextracellular space.

FIG. 25 shows an alternative sequence of the construct of FIG. 12(antibody rituximab), wherein the restriction sites have been modifiedas compared to SEQ ID NO: 61165 of FIG. 12 (SEQ ID NO: 61209). Forcloser information with regard to the description of various sequenceelements it is referred to FIG. 12 .

FIG. 26 shows an alternative sequence of the construct of FIG. 17(antibody cetuximab), wherein the restriction sites have been modifiedas compared to SEQ ID NO: 61170 of FIG. 17 (SEQ ID NO: 61210). Forcloser information with regard to the description of various sequenceelements it is referred to FIG. 17 .

FIG. 27 shows an alternative sequence of the construct of FIG. 22(antibody trastuzumab), wherein the restriction sites have been modifiedas compared to SEQ ID NO: 61175 of FIG. 22 (SEQ ID NO: 61211). Forcloser information with regard to the description of various sequenceelements it is referred to FIG. 22 .

FIG. 28 shows for Example 2 the median survival time of mice injectedwith mRNA encoding the antibody trastuzumab (Herceptin) as compared tothe median survival time of naïve control mice in an in vivo tumormodel. Briefly, BALB/c nu/nu mice (n=14 per group) were subcutaneouslyimplanted with slow-release estrogen pellets (0.72 mg 17β-estradiol).Mice were inoculated subcutaneously with 10×10⁶ BT-474 tumour cells (100μl of a cell/matrigel suspension) per mouse on day 0. Treatment wasstarted on day 11 when tumors became injectable. Mice were treated twiceweekly for up to 3.5 weeks with a single dose of 50 μg of mRNA (R1965)in a 50 μl injection volume (Ringer Lactate buffer).

FIG. 29 shows for Example 3 the concentration of cetuximab in thesupernatant of R3578-transfected cells (in vitro antibody expressionstudy). Briefly, HEK293T cells were transfected with 1 μg or 4 μg ofmRNA (R3578) using the Lipofectamine2000 reagent. 24 hours after thetransfection, the supernatant was collected and used for staining ofA431 cells (EGFR-expressing cell line) and analysed by flow cytometry(FACS). The concentration of Cetuximab in the supernatant of thetransfected cells was calculated using a standard curve generated withthe commercially available Cetuximab protein.

FIG. 30 shows for Example 3 the median survival time of mice injectedwith mRNA encoding the antibody cetuximab (Erbitux) as compared to themedian survival time of naïve control mice in an in vivo tumor model.Briefly, BALB/c nu/nu mice were inoculated subcutaneously in the rightflank (near the dorsal region) with a cell suspension of about 5×10⁶SW48 cells (human colon cancer cell line; 100 μl of a cell/matrigelsuspension). When the tumor reached a volume of 400-500 mm³, the tumortissue blocks were harvested for transplantation. SW48 tumor blocks(about 1.5 mm×1.5 mm×1.5 mm in size) were subcutaneously transplanted inthe right flank (near the dorsal region) of 125 animals; eventually 40tumor-bearing mice were enrolled in the study and were assigned to oneof the following four groups (n=10 per group): untreated, Ringer Lactate(“RiLa”), 50 μg mRNA encoding cetuximab (“R3578 (50 μg)”) and 100 μgmRNA encoding cetuximab (“R3578 (100 μg)”). Except for the untreatedgroup, all mice received the respective “treatment” (RiLa or 50 or 100μg mRNA) every 3 days for a total of seven injections (21 days).

FIG. 31 shows for Example 3 the concentration of cetuximab antibody inthe sera of treated mice. Briefly, the sera from mice injected with 100μg and 50 μg of R3578 were collected 24 hours after the thirdapplication and tested by flow cytometry (FACS) for the presence offunctional antibodies as described above. The sera from untreatedanimals and mice injected with RiLa served as controls.

FIG. 32 shows for Example 4 the reduction of the mean tumor volume aftertreatment with mRNA encoding Blinatumomab (R3981) versus untreated (RiLacontrol buffer experiment). Mean tumor volume after treatment with R3981or buffer is depicted. NOG mice were subcutaneously challenged with amixture of NALM-6 cells and human PBMCs followed by treatment with R3981or buffer as a control (5x on consecutive days). Tumor growth wasmeasured using caliper and tumor growth curves are depicted. Contrary tothe control group, only one of six mice in the cohort treated with themRNA encoding Blinatumomab developed a measurable tumor. As a result, astatistically significant inhibition of tumor growth was observedcompared to the control group.

FIG. 33 shows for Example 4 the tumor volume of R3981- andbuffer-treated mice on day 34. Day 34 was chosen for this analysis asthe last day when all animals in all groups were still alive andtherefore the mean tumor volumes could be compared. The treatment withthe mRNA encoding Blinatumomab (R3981) significantly inhibited tumorgrowth compared to the buffer control. The dots represent the tumorvolume of individual mice and the horizontal line represents the median.

FIG. 34 shows for Example 4 the median survival time of mice injectedwith mRNA encoding the antibody blinatumomab (“R3981”) as compared tothe median survival time of buffer control mice in an in vivo tumormodel. Briefly, survival proportions after tumor challenge with NALM-6cells were investigated. Survival in groups treated with R3981 or bufferare shown. MS: median survival time.

FIG. 35 shows for Example 5 expression of anti-BoNTx antibodies by mRNAtransfected cells evaluated by Western blot analysis. Aliquots of celllysates and supernatants were separated by SDS-PAGE, blotted onto amembrane, and stained with an anti-human detection antibody recognizingheavy as well as light chain. Samples from cells transfected with mRNAencoding an unrelated antibody were used as positive control.Mock-transfected cells served as negative control.

FIG. 36 shows for Example 6 the expression of anti-HA antibodies by mRNAtransfected cells evaluated by Western blot analysis. Aliquots of celllysates and supernatants were separated by SDS-PAGE, blotted onto amembrane, and stained with an anti-human detection antibody recognizingheavy as well as light chain. 100 ng of a recombinant antibody were usedas positive control and for rough quantification of mRNA-mediatedantibody expression. Mock-transfected cells served as negative control.

FIG. 37 shows for Example 6 the production of functional anti-HAantibodies by mRNA transfected cells evaluated by flow cytometry. 24 hafter transfection of BHK cells with mRNA-encoded anti-HAn antibodysupernatant was collected and used for staining of HA-expressing HeLacells. The supernatant of mock-transfected cells served as negativecontrol.

FIG. 38 shows for Example 7 the production of functional anti-RAV Gantibodies by mRNA transfected cells evaluated by flow cytometry. 24 hafter transfection of BHK cells with mRNA-encoded anti-RAV G antibodysupernatant was collected and used for staining of RAV G-expressing HeLacells. The supernatant of mock-transfected cells served as negativecontrol.

FIG. 39 shows the complete mRNA sequence “R1965” coding for the antibodyTrastuzumab (Herceptin) (cf. Example 1).

FIG. 40 shows the complete mRNA sequence “R3578” coding for the antibodyCetuximab (Erbitux) (cf. Example 1).

FIG. 41 shows the complete mRNA sequence “R3981” coding for the antibodyBlinatumomab (cf. Example 1).

FIG. 42 shows for Example 8 data resulting from an ELISA assay (titersof anti-HIV antibodies expressed by mRNA). Individual supernatants(triplicates; pooled) were analyzed by IgG-specific ELISA. For mockco-transfection, an mRNA encoding eGFP was used.

FIG. 43 shows for Example 8 the HIV entry in MAGI-R5 cells in a MagiR5-Tropic Antiviral Assay (VC=virus control; CC=cell control) of acontrol without RNA (A); the HIV entry in MAGI-R5 cells in a MagiR5-Tropic Antiviral Assay (VC=virus control; CC=cell control) ofmRNA-encoded VRC01 (B); and the HIV entry in MAGI-R5 cells in a MagiR5-Tropic Antiviral Assay (VC=virus control; CC=cell control) ofcommercially available recombinant VRC01 control (C).

FIG. 44 shows for Example 9 the concentration of human antibodies in thesupernatant of R3917-transfected HEK293T cells evaluated by ELISA. Theplates were coated with anti-human antibodies, followed by incubationwith the supernatant of R3917-transfected cells and anti-human detectionantibodies. The concentration of human antibodies was calculated fromthe standard curve generated using commercially available Rituximab. Thesupernatant from the sham-transfected cells (WFI, water for injection)served as a control.

FIG. 45 shows for Example 9 the concentration of the functionalRituximab antibodies in the supernatant of R3917-transfected cellsevaluated by flow cytometry. 24 h after the transfection of HEK293Tcells with mRNA-encoded Rituximab (R3917) supernatant was collected andused for staining of CD20-expressing Raji cells. The concentration ofRituximab was calculated from the standard curve generated usingcommercially available Rituximab. The supernatant from thesham-transfected cells (WFI) served as a control.

FIG. 46 shows for Example 10 the expression of anti-RSV F antibodies bymRNA transfected cells evaluated by Western blot analysis. Aliquots ofcell lysates and supernatants were separated by SDS-PAGE, blotted onto amembrane, and stained with an anti-human detection antibody recognizingheavy as well as light chain. 100 ng of a recombinant antibody were usedas positive control and for rough quantification of mRNA-mediatedantibody expression. Mock-transfected cells served as negative control.

EXAMPLES

The Examples shown in the following are merely illustrative and shalldescribe the present invention in a further way. These Examples shallnot be construed to limit the present invention thereto.

Example 1: Preparation of an mRNA Encoding Heavy and Light ChainVariable Regions and Antibody Expression

1.1 Preparation of Expression Vectors for Modified RNA Sequences:

For the production of modified RNA sequences according to the invention,the GC-enriched and translation-optimized DNA sequences which code for aheavy chain and a light chain of the antibodies shown below in Table 12(e.g. cetuximab (Erbitux), trastuzumab (Herceptin) and rituximab(Rituxan), cf. SEQ ID NO: 61161-61175, where SEQ ID NO: 61161, 61163,61166, 61168, 61171 and 61173 represent the particular coding sequenceswhich are not GC-optimized of the heavy and the light chains of theseantibodies and SEQ ID NO: 61162, 61164, 61165, 61167, 61169, 61170,61172, 61174, and 61175 represent the coding GC-enriched sequences (seeabove)) were cloned into the pCV19 vector (CureVac GmbH) by standardmolecular biology methods. To ensure equimolar expression of the twochains, an IRES (internal ribosomal entry site) was introduced. Themutated 3′ UTR (untranslated region) of the alpha-globin gene and apolyA-polyC tail at the 3′ end serve for additional stabilizing of themRNA. The signal peptide of the HLA-A*0201 gene is coded for secretionof the antibody expressed. A His tag was additionally introduced fordetection of the antibody. FIG. 6 shows the expression constructs usedfor cetuximab (Erbitux), trastuzumab (Herceptin) and rituximab(Rituxan).

TABLE 12 SEQ ID NOs of exemplified and preferred antibodies encoded bythe mRNA according to the present invention and of exemplified andpreferred mRNAs according to the invention Protein heavy Protein lightOptimized CDS Optimized CDS chain (SEQ ID chain (SEQ ID heavy chainlight chain mRNA sequence Antibody NO) NO) (SEQ ID NO) (SEQ ID NO) (SEQID NO) Cetuximab 61237 61238 61240 61241 61243 (“R3578”) (Erbitux)Trastuzumab 61270 61271 61273 61274 61276 (“R1965”) Rituximab 6130361305 61306 61308 61310 (Rituxan) (“R3001”) Blinatumomab 61640 — 61642(single — 61643 (“R3981”) (single chain) chain) Anti-BoNTx_v1 6160361606 61604 61607 61605 (heavy chain; R4120”) 61608 (light chain;“R4122”) Anti-BoNTx_v2 61609 61612 61610 61613 61611 (heavy chain;R5045”) 61614 (light chain; “R5046”) Anti-HA 61456 61457 61458 6145961465 CR8033_v1 (“R3996”) Anti-HA 61469 61470 61471 61472 61474CR8033_v2 (“R3998”) Anti-HA 61475 61476 61477 61478 61480 CR8033_v3(“R4000”) Anti-HA 61481 61482 61483 61484 61486 CR8033_v4 (“R4002”)Anti-HA 61487 61488 61489 61490 61492 CR8033_v5 (“R4004”) Anti-HA 6149361494 61495 61496 61498 CR8033_v6 (“R4012”) Anti-Rabies 61408 6141261409 61413 61410 (heavy chain; “R4116”) 61414 (light chain; “R4118”)Anti-Rabies 61384 61385 61402 61403 61405 (“R3059”) Anti-HIV 61370 6138161371 61382 61372 (heavy chain; “R5319”) 61383 (light chain; “R5320”)Rituximab 61320 61332 61321 61333 61337 (Rituxan) (“R3917”) Anti-RSV F61675 61697 61676 61698 61677 (heavy chain; “R4179”) 61699 (light chain;“R4181”) Anti-RSV F 61686 61708 61687 61709 61688 (heavy chain; “R4180”)61710 (light chain; “R4182”) Anti-RSV F 61660 61661 61662 61663 61666(“R3060”)

Table 13 below shows further RNA constructs, which were produced,including their SEQ ID NOs and the antibodies, which they encode.

TABLE 13 SEQ ID NOs of exemplified and preferred mRNAs according to theinvention encoding the indicated antibodies. RNA construct name SEQ IDNO Encoded antibody R3578 61243 Cetuximab (Erbitux) R3000 61244Cetuximab (Erbitux) R1965 61276 Trastuzumab (Herceptin) R2999 61277Trastuzumab (Herceptin) R3012 61278 Trastuzumab (Herceptin) R3001 61310Rituximab R3484 61311 Rituximab R4128 61322 Rituximab R5910 61323Rituximab R4129 61334 Rituximab R5911 61335 Rituximab R3917 61337Rituximab R4126 61348 Lexatumumab R4127 61359 Lexatumumab R3985 61361Lexatumumab R5319 61372 VRC01 R5320 61383 VRC01 R3059 61404 SO57 R305961405 SO57 R3061 61406 SO57 R4634 61407 SO57 R4116 61410 SO57 R463561411 SO57 R4118 61414 SO57 R4636 61415 SO57 R4640 61416 SO57 R464061417 SO57 R5230 61428 anti-rabies_Mouse_ab R5231 61439anti-rabies_Mouse_ab R4112 61460 CR8033 R4530 61461 CR8033 R4114 61462CR8033 R4531 61463 CR8033 R3996 61465 CR8033 R4633 61466 CR8033 R463961467 CR8033 R4639 61468 CR8033 R3998 61473 CR8033 R3998 61474 CR8033R4000 61479 CR8033 R4000 61480 CR8033 R4002 61485 CR8033 R4002 61486CR8033 R4004 61491 CR8033 R4004 61492 CR8033 R4012 61497 CR8033 R401261498 CR8033 R4007 61520 5J8 R4008 61542 FLA5.10 R4010 61564 PN-SIA49R5417 61575 Ipilimumab R5418 61586 Ipilimumab R4120 61603 anti-BoNT-AR4120 61604 anti-BoNT-A R4120 61605 anti-BoNT-A R4122 61606 anti-BoNT-AR4122 61607 anti-BoNT-A R4122 61608 anti-BoNT-A R5045 61609 anti-BoNT-AR5045 61610 anti-BoNT-A R5045 61611 anti-BoNT-A R5046 61612 anti-BoNT-AR5046 61613 anti-BoNT-A R5046 61614 anti-BoNT-A R3118, R3729 61615anti-BoNT-A R3118 61616 anti-BoNT-A R3729 61617 anti-BoNT-A R3979 61638Blinatumomab R3981 61643 Blinatumomab R3058 61665 anti-RSV R3060 61666anti-RSV R4179 61677 anti-RSV R4180 61688 anti-RSV R4181 61699 anti-RSVR4182 61710 anti-RSV R4124 61721 anti-VEGFR2 R4125 61732 anti-VEGFR2R3983 61733 anti-VEGFR2 R3983 61734 anti-VEGFR2

1.2 Preparation of the G/C-Enriched and Translation-OptimizedAntibody-Coding mRNA

An in vitro transcription was carried out by means of T7 polymerase(T7-Opti mRNA Kit, CureVac, Tubingen, Germany), followed by purificationwith Pure Messenger™ (CureVac, Tubingen, Germany). For this, a DNasedigestion was first carried out, followed by an LiCl precipitation andthereafter an HPLC using a porous reverse phase as the stationary phase(PURE Messenger).

1.3 Cell Lines

RNA-based expression of humanised antibodies was done in either CHO-K1or BHK-21 (Syrian hamster kidney, HER2-negative) cells. The tumour celllines BT-474, A-431 and Raji strongly expressing HER2, EGFR and CD20,respectively, were used to record antibody levels by FACS analysis. Allcell lines except CHO were maintained in RPMI medium supplemented withFCS and glutamine according to the supplier's information. CHO cellswere grown in Ham's F12 supplemented with 10% FCS. All cell lines wereobtained from the German collection of cell cultures (DSMZ,Braunschweig, Germany).

1.4 Antibody Expression

Various amounts of mRNA (G/C enriched as defined by FIGS. 12, 17, 22,25, 26, 27 ) encoding the humanised antibodies Herceptin, Erbitux, andRituxan, respectively, were transfected into either CHO or BHK cells byelectroporation (300 V, 450 μF for CHO and 300 V, 150 μF for BHK). Aftertransfection, cells were seeded onto 24-well cell culture plates at adensity of 200.000 to 400.000 cells per well. For collection of secretedprotein, medium was replaced by 250 μl of fresh medium after cellattachment to the plastic surface. Secreted protein was collected for24-96 hours and stored at 4° C. In addition, cells were harvested into50 μl of phosphate buffered saline (1×PBS buffer) containing 0.5% BSAand broken up by three freeze-thaw cycles. Cell lysates were cleared bycentrifugation and stored at −80° C.

1.5 Western Blot Analysis

In order to detect translation of transfected RNA, proteins from eithercell culture supernatants or cell lysates were separated by a 12%SDS-PAGE and blotted onto a nitrocellulose membrane. Humanisedantibodies Herceptin (Roche), Erbitux (Merck KGAA), and Mabthera=Rituxan(Roche) were used as controls. After blotting was completed, membraneswere consecutively incubated with a biotinylated goat anti-human IgGantibody (Dianova), streptavidin coupled to horseradish peroxidase (BD),and a chemiluminescent substrate (SuperSignal West Pico, Pierce).Staining was detected with a Fuji LAS-1000 chemiluminescence camera.Results are shown in FIG. 23 .

1.6 FACS Analysis

Functional antibody formation can be demonstrated by FACS staining ofantigen-expressing target cells. In order to examine the production offunctional antibodies, cell culture supernatants of RNA-transfectedcells were collected after 48 to 96 hours. Approximately 200.000 targetcells expressing the respective antigen were incubated with eithercontrol antibodies (Herceptin, Erbitux, Mabthera) or cell culturesupernatants. For detection of bound antibodies, cells were stained withbiotinylated goat anti-human IgG antibody (Dianova) and PE-labelledstreptavidin (Invitrogen). Cells were analysed on a FACSCalibur (BD).

Example 2: Effects of an mRNA Encoding Trastuzumab (Herceptin) in an InVivo Tumor Model

2.1 Preparation of mRNA

For the present example a DNA sequence encoding the Trastuzumab proteinwas prepared and used for subsequent in vitro transcription reactions asdescribed in Example 1.

Briefly, a vector for in vitro transcription was constructed containinga T7 promoter and a GC-enriched sequence coding for the heavy and lightchain of the Trastuzumab antibody, separated by the internal ribosomalentry site (IRES) from Encephalomyocarditis virus (EMCV). An α-globin3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, wasinserted 3′ of the open reading frame (ORF). The C30 sequence wasfollowed by a restriction site used for linearization of the vectorbefore in vitro transcription. This DNA construct is shown in FIGS. 22and 39 (SEQ ID NO: 61175). This vector was transcribed in vitro in thepresence of a cap analog resulting in 5′-capped (m7G) mRNA (“R1965”).

2.2 Animal Study

Before the start of the experiment, 7 weeks old female BALB/c nu/nu mice(n=14 per group) were subcutaneously implanted with slow-releaseestrogen pellets (0.72 mg 17β-estradiol) because the BT-474 cell line isestrogen receptor positive and estrogen enhances tumorigenicity. Micewere inoculated subcutaneously with 10×10⁶ BT-474 tumour cells (100 μlof a cell/matrigel suspension) per mouse on day 0. Treatment was startedon day 11 when tumors became injectable. Mice were treated twice weeklyfor up to 3.5 weeks with a single dose of 50 μg of mRNA (R1965) in a 50μl injection volume (Ringer Lactate buffer).

2.3 Statistical Analysis

The statistical difference in survival was evaluated using Mantel-Cox(p=0.0499) and Gehan-Breslow (p=0.0425) tests, which assume theproportional hazards or give more weight to deaths at early time points,respectively.

2.4 Results

Results are shown in FIG. 28 . This experiment demonstrates theeffectiveness of the mRNA-encoded antibody Trastuzumab with respect toenhancing survival of nude BALB/c mice harboring a human tumor cellxenograft (BT-474 breast cancer cell line). The Her-2 positive tumorcell line BT-474 was used to establish tumors which were then treated byintratumoral injections of mRNA encoding the anti-Her-2 antibodyTrastuzumab. The effectiveness of treatment was demonstrated byprolonged survival of treated animals compared to untreated animals(FIG. 28 ). The median survival time compared to untreated mice wasincreased by 5.5 days.

Example 3: In Vitro and In Vivo Effects of an mRNA Encoding Cetuximab(Erbitux)

3.1 Preparation of mRNA

For the present example a DNA sequence encoding the Cetuximab proteinwas prepared and used for subsequent in vitro transcription reactions asdescribed in Example 1.

Briefly, a vector for in vitro transcription was constructed containinga T7 promoter and a GC-enriched sequence coding for the heavy and lightchain of the Cetuximab antibody, separated by the internal ribosomalentry site (I RES) from Encephalomyocarditis virus (EMCV). An α-globin3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, wasinserted 3′ of the open reading frame (ORF). The C30 sequence wasfollowed by a restriction site used for linearization of the vectorbefore in vitro transcription. This DNA construct is shown in FIGS. 17and 40 (SEQ ID NO: 61170). This vector was transcribed in vitro. Afterin vitro transcription, the mRNA was enzymatically capped andpolyadenylated. The resulting mRNA was termed “R3578”.

3.2 In Vitro Expression of the Antibody Cetuximab

The expression of functional antibodies by mRNA-encoded Cetuximab wasevaluated in vitro. To this end, HEK293T cells were transfected with 1μg or 4 μg of mRNA (R3578) using the Lipofectamine2000 reagent. 24 hoursafter the transfection, the supernatant was collected and used forstaining of A431 cells (EGFR-expressing cell line) and analysed by flowcytometry (FACS). The concentration of Cetuximab in the supernatant ofthe transfected cells was calculated using a standard curve generatedwith the commercially available Cetuximab protein. As shown in FIG. 29 ,transfection with 4 μg of mRNA (R3578) resulted in the production offunctional antibodies at the concentration of approximately 40 ng/ml.

3.3 Animal Study

6-7 weeks old female BALB/c nu/nu mice (n=10) were inoculatedsubcutaneously in the right flank (near the dorsal region) with a cellsuspension of about 5×10⁶ SW48 cells (human colon cancer cell line; 100μl of a cell/matrigel suspension). When the tumor reached a volume of400-500 mm³, the tumor tissue blocks were harvested for transplantation.SW48 tumor blocks (about 1.5 mm×1.5 mm×1.5 mm in size) weresubcutaneously transplanted in the right flank (near the dorsal region)of 125 animals; eventually 40 tumor-bearing mice were enrolled in thestudy. The animals were weighed and randomized into treatment groupswhen the tumor size reached a volume of 100-150 mm³. The date to starttreatment was designated as day 0. All groups consisted of 10 animalseach. The mRNA or Ringer lactate buffer was administered in a 50 μlvolume intratumorally as shown in Table 14.

TABLE 14 Group designation and dosing schedule No. Frequency of an- anddays of dosing Group imals Treatment Dose (after randomization) 1 10Untreated — — 2 10 Ringer Lactate — Every 3 days for a total number of 7injections 3 10 R3578 (Cetuximab 100 μg Every 3 days for a total(Erbitux) SEQ ID number of 7 injections NO: 61243) 4 10 R3578 (Cetuximab 50 μg Every 3 days for a total (Erbitux) SEQ ID number of 7 injectionsNO: 61243)

Animals in a deteriorating condition with a body weight loss greaterthan 30% or bearing a tumor exceeding 2,000 mm³ in size were euthanized.

Tumor volume, expressed in mm³, was calculated using the followingformula, in which “a” and “b” are the long and the short diameters of atumor, respectively.V(mm³)=(a×b ²)/2

Statistical Analysis

The statistical difference in survival was evaluated using Mantel-Coxand Gehan-Breslow tests, which assume the proportional hazards or givemore weight to deaths at early time points, respectively. The hazardratio (logrank) as part of the survival analysis of two data sets wasincluded in the results. Hazard is defined as the slope of the survivalcurve and the hazard ratio compares the rate of death between twogroups. The statistical difference between groups was evaluated usingMann-Whitney test.

Results

This experiment demonstrates the efficacy of the mRNA-encoded antibodyCetuximab with respect to enhancing survival of nude BALB/c miceharboring a human tumor cell xenograft (SW48 human colon cancer cellline).

As shown in FIG. 30 , compared to the buffer-treated mice, the treatmentwith R3578 increased the time to the first death incident by 20% (7days; first incident at day 42 compared to day 35 in RiLa-treated mice)in the group injected with 100 μg of mRNA-encoded Cetuximab (FIG. 30A)and approximately 15% (5 days) in the group treated with 50 μg of R3578(FIG. 30B). Moreover, at day 51 all mice in the RiLa group were dead,whereas in total four mice treated with R3578 were still alive (onemouse in group treated with 100 μg R3578 and three mice treated with 50μg R3578) were still alive. Consequently, the median survival timecompared to RiLa-injected mice was increased in animals treated with 100μg or 50 μg of mRNA-encoded Cetuximab.

To confirm the expression and functionality of mRNA-encoded Cetuximab invivo, the sera from mice injected with 100 μg and 50 μg of R3578 werecollected 24 hours after the third application and tested by flowcytometry (FACS) for the presence of functional antibodies as describedabove. The sera from untreated animals and mice injected with RiLaserved as controls. As shown in FIG. 31 , Cetuximab antibodies wereclearly detectable in both groups injected with R3578 confirming the invivo expression and functionality (capability to bind to EGFR) ofmRNA-encoded antibodies.

Example 4: Effects of an mRNA Encoding a Single Chain, BispecificAntibody (Blinatumomab) in an In Vivo Tumor Model

As a further example, mRNA coding for Blinatumomab was tested in vivo (abispecific anti-CD3/anti-CD19 antibody).

4.1 Preparation of mRNA

For the present example a DNA sequence encoding the Blinatumomabantibody was prepared and used for subsequent in vitro transcriptionreactions in a similar manner as described in Example 1, except that theantibody encoded by the mRNA was Blinatumomab.

Briefly, a vector for in vitro transcription was constructed containinga T7 promoter and a GC-enriched sequence coding for Blinatumomab (afusion protein consisting of the variable regions of two single-chainmonoclonal antibodies (scFvs)—CD19 and CD3—covalently linked by anon-immunogenic five-amino acid chain). An α-globin 3′-UTR, followed byan A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the openreading frame (ORF). The C30 sequence was followed by a restrictionenzyme site used for linearization of the vector before in vitrotranscription. The respective CDS sequence as well as the sequence ofthe mRNA can be retrieved from Table 12 (Example 1). This vector wastranscribed in vitro in the presence of a cap analog resulting in5′-capped (m7G) mRNA (“R3981”).

4.2 Animal Study

NOG female mice (n=6 per group) were inoculated subcutaneously in theright flank with a cell suspension consisting of 1×10⁶ NALM-6 cells(human pre-B cell leukemia) and 1×10⁸ freshly isolated human PBMCs(peripheral blood mononuclear cells). The NALM-6 cells were co-injectedtogether with human peripheral mononuclear cells (PBMCs) as source ofhuman T-cells because Blinatumomab as a bispecific antibody recognizesthe CD19 protein on the human NALM-6 cells and the CD3 protein on thehuman T cells. One hour after cell inoculation mice were treated byperitumoral injections of the mRNA encoding Blinatumomab (“R3981”; 100μg) or buffer (Ringer Lactate) as a control and this treatment wasrepeated on five consecutive days. The detailed group description isdepicted in Table 15.

TABLE 15 Animal groups and dosing schedule. No. Treatment Group ofanimals PBMCs Treatment Dose schedule 1 6 — Ringer Lactate — At fiveconsecutive days beginning at day 0 2 6 + Ringer Lactate — At fiveconsecutive days beginning at day 0 3 6 + R3981 100 μg At five(Blinatumomab consecutive SEQ ID NO: days beginning 61643) at day 0

The animal health status was checked daily. Animals in a deterioratingcondition with a body weight loss greater than 20% or bearing a tumorexceeding 2 cm³ in size were euthanized.

Tumor volume, expressed in cm³, was calculated using the followingformula, in which “a” and “b” are the long and the short diameters of atumor, respectively.V(cm³)=(a×b ²)/2

Statistical Analysis

The statistical analysis of tumor growth curves was performed using2-way ANOVA test with Bonferroni post test. The statistical analysis ofdifferences in tumor volume at day 34 was performed using t-test withWelch's correction (the data were normally distributed as determined byKolmogorov-Smirnov normality test). The statistical difference insurvival was evaluated using Mantel-Cox test.

Results

This experiment shows the efficacy of the mRNA-encoded Blinatumomabantibody in terms of reduction of tumor growth and enhancing survival ofNOG mice harboring a human cell xenograft (NALM-6 human pre-B leukemiacells).

Subcutaneously injected NALM-6 cells developed palpable tumors incontrol treated mice at day 25. Thereafter, the tumor rapidly increasedin size in all buffer-treated animals (FIG. 32 ). Contrary to thecontrol group, only one of six mice in the cohort treated with themRNA-encoded Blinatumomab developed a measurable tumor. As a result, astatistically significant inhibition of tumor growth in the groupinjected with R3981 in comparison to buffer-treated mice was observed.

To further demonstrate the impact of the mRNA-encoded Blinatumomabtreatment on the growth of the subcutaneously injected NALM-6 cells thetumor volume of each mouse at day 34 was depicted (FIG. 33 ). Day 34 waschosen for this analysis as the last day when all animals in all groupswere still alive and therefore the mean tumor volumes can be compared.As shown in FIG. 33 , treatment with R3981 significantly inhibited tumorgrowth compared to the buffer control.

In addition to the effect on tumor growth, the difference in survivalbetween the experiments groups was evaluated. As shown in FIG. 34 ,treatment with the mRNA-encoded Blinatumomab significantly enhanced micesurvival compared to the buffer-treated animals. At day 49, all animalsin the R3981-treated group were alive (5/6 mice were completelytumor-free and only one mouse had a measurable tumor) compared to thecontrol group where five of six animals were already dead. Consequently,the R3981-treated group had an undefined median survival time (MS),whereas the buffer-treated group reached MS at 38.25 days. Thustreatment with the mRNA encoding Blinatumomab significantly enhanced thesurvival compared to the buffer-treated animals.

Example 5: In Vitro Expression of mRNA-Encoded Anti-BoNTx Antibody

In this experiment the in vitro expression of mRNA-encoded anti-BoNTxantibody was evaluated.

5.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directedagainst the Botulinum neurotoxin (BoNTx) (Amersdorfer et al., 1997.Infect. Immun. 65(9):3743-52) were prepared and used for subsequent invitro transcription reactions. Heavy (HC) and light (LC) chain of theantibody were encoded as separate entities and constructs differedregarding signal peptides used for protein secretion (Table 16).

Vectors for in vitro transcription were constructed containing a T7promoter and a GC-enriched sequence coding for the heavy and light chainof the antibody, respectively. An α-globin 3′-UTR, followed by an A64poly(A) sequence and a C30 sequence, was inserted 3′ of the open readingframe (ORF). The C30 sequence was followed by a restriction site usedfor linearization of the vector before in vitro transcription. Therespective CDS sequences as well as the sequences of the mRNA can beretrieved from Table 12 (Example 1). For capping of the mRNA, in vitrotranscription was conducted in the presence of cap analog.

TABLE 16 mRNA constructs encoded signal mRNA antibody peptide RNA designR5045 (any of SEQ ID NOs anti- HLA-2 HC and LC 61609-61611)/R5046 (anyBoNTx encoded on of SEQ ID NOs 61612-61614) separate mRNA moleculesR4120 (any of SEQ ID NOs anti- immuno- HC and LC 61603-61605)/R4122 (anyBoNTx globulin encoded on of SEQ ID NOs 61606-61608) separate mRNAmolecules

5.2 In Vitro Expression of the Anti-BoNTx Antibody Evaluated by WesternBlot Analysis

The expression of mRNA-encoded anti-BoNTx antibody was evaluated invitro. To this end, BHK cells were transfected with 10 μg of mRNA usingthe Lipofectamine2000 reagent. 24 hours after the transfection, cellsand supernatants were collected for Western blot analysis to determinethe expression of human antibodies.

5.3 Results

As shown in FIG. 35 , human antibodies were clearly detectable inlysates and supernatants of mRNA-transfected cells. The mRNA-transfectedcells produced both, heavy and light chain, and gave rise to high andequivalent levels of both chains in the supernatant, thus stronglysuggesting the production of correctly folded and assembled antibodies.Expression was specific as no antibodies were detected in thesupernatants of mock-transfected cells.

Example 6: In Vitro Expression of mRNA-Encoded Anti-Influenza (Anti-HA)Antibody

In these experiments the in vitro expression and binding to the nativeantigen of mRNA-encoded CR8033 (anti-HA: anti-hemagglutinin) antibodywas evaluated.

6.1 Preparation of mRNA

For the present example DNA sequences encoding the CR8033anti-hemagglutinin antibody (Dreyfus et al., 2012. Science337(6100):1343-8) were prepared and used for subsequent in vitrotranscription reactions. The antibody was represented by bi-cistronicsequences in which heavy chain (HC) and light chain (LC) were separatedby the internal ribosomal entry site (IRES) from eitherEncephalomyocarditis (EMCV) or Foot-and-mouth disease (FMDV) virus.Moreover, sequences varied with respect to the order of heavy and lightchain or utilized different signal peptides for the secretion of bothchains (Table 17).

Vectors for in vitro transcription were constructed containing a T7promoter and a GC-enriched sequence coding for the heavy and light chainof the antibody. An α-globin 3′-UTR, followed by an A64 poly(A) sequenceand a C30 sequence, was inserted 3′ of the open reading frame (ORF). TheC30 sequence was followed by a restriction site used for linearizationof the vector before in vitro transcription. The respective CDSsequences as well as the sequences of the mRNA can be retrieved fromTable 12 (Example 1). For capping of the mRNA, in vitro transcriptionwas conducted in the presence of cap analog.

TABLE 17 mRNA constructs encoded mRNA antibody signal peptide RNA designR3996 (SEQ ID CR8033 immunoglobulin HC:EMCV-IRES:LC NO: 61465) (anti-HA)R4000 (SEQ ID CR8033 Albumin (ALB) HC:EMCV-IRES:LC NO: 61479, (anti-HA)61480)

6.2 In Vitro Expression of the CR8033 Antibody Evaluated by Western BlotAnalysis

The expression of antibodies by mRNA-encoded CR8033 was evaluated invitro. To this end, BHK cells were transfected with 10 μg of mRNA usingthe Lipofectamine2000 reagent. 24 hours after the transfection, cellsand supernatants were collected for Western blot analysis to determinethe expression of human antibodies.

6.3 In Vitro Expression of Functional CR8033 Antibody Evaluated by FlowCytometry

To confirm the functionality of the in vitro-produced mRNA-encodedantibody, the supernatant obtained after transfection of BHK cells (asdescribed above) was used for staining of hemagglutinin (HA) expressingHeLa cells. To this end, HeLa cells were transfected with 1 μg ofHA-expressing mRNA using the Lipofectamine2000 reagent and, afterstaining, analyzed by flow cytometry (FACS). The expression is presentedas median fluorescence intensity.

6.4 Results

As shown in FIG. 36 , mRNA-transfected cells produced both, heavy andlight chain, and gave rise to high and equivalent levels of both chainsin the supernatant, thus strongly suggesting the production of correctlyfolded and assembled antibodies. Expression was specific as noantibodies were detected in the supernatants of mock-transfected cells.

As shown in FIG. 37 , all antibody-encoding mRNAs resulted in theproduction of functional antibodies.

Example 7: In Vitro and In Vivo Expression of mRNA-Encoded Anti-Rabies(anti-RAV G) Antibody

In this experiment the in vitro expression and binding to the nativeantigen of mRNA-encoded anti-RAV G antibody was evaluated.

7.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directedagainst the Rabies virus glycoprotein (RAV G) (SO57 antibody; Prosniaket al., 2003. J. Infect. Dis. 188(1):53-6) were prepared and used forsubsequent in vitro transcription reactions. Heavy (HC) and light (LC)chain of the antibody were either linked by the internal ribosomal entrysite (IRES) from Encephalomyocarditis virus (EMCV) or encoded asseparate entities (Table 18).

Vectors for in vitro transcription were constructed containing a T7promoter and a GC-enriched sequence coding for the heavy and/or lightchain of the antibody. An α-globin 3′-UTR, followed by an A64 poly(A)sequence and a C30 sequence, was inserted 3′ of the open reading frame(ORF). The C30 sequence was followed by a restriction site used forlinearization of the vector before in vitro transcription. Therespective CDS sequences as well as the sequences of the mRNA can beretrieved from Table 12 (Example 1). For capping of the mRNA, in vitrotranscription was conducted in the presence of cap analog.

TABLE 18 mRNA constructs encoded signal mRNA antibody peptide RNA designR4116 (SEQ ID NO: anti-RAV G immuno- HC and LC encoded 61410)/R4118 (SEQglobulin on separate ID NO: 61414) mRNA molecules R3059 (SEQ ID NO:anti-RAV G immuno- HC:EMCV-IRES:LC 614104/61405) globulin

7.2 In Vitro Expression of the Functional Anti-RAV G Antibody Evaluatedby Flow Cytometry

To demonstrate functionality of in vitro-produced mRNA-encoded antibody,the supernatant obtained after transfection of BHK cells was used forstaining of RAV G expressing HeLa cells. To this end, BHK cells weretransfected with 10 μg of antibody-encoding mRNA and HeLa cells weretransfected with 1 μg of RAV G-expressing mRNA, respectively, using theLipofectamine2000 reagent. After staining, HeLa cells were analyzed byflow cytometry (FACS). The expression level of the anti-RAV G antibodyis presented as median fluorescence intensity.

7.3 Results

As shown in FIG. 38 , all antibody-encoding mRNAs resulted in theproduction of functional antibodies. However, the antibody produced frommRNA molecules separately encoding heavy chain and light chain producedhigher antibody levels as compared to the antibody produced from an mRNAmolecule encoding both, heavy chain and light chain. All antibodies werefunctional as they recognized and bound RAV G antigen expressed on thesurface of HeLa cells. Encoding heavy and light chain by separate mRNAmolecules instead of a bi-cistronic construct strongly increased theamount of functional antibodies secreted by mRNA-transfected cells.

Example 8: In Vitro Expression of mRNA-Encoded Anti-HIV Antibody

In this experiment the in vitro expression and neutralization activityto the HIV-1Ba-L HIV strain was tested for RNA-encoded antibodies.

8.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directedagainst the HIV (VRC01; Wu et al., Science 329(5993):856-861, 2010) wereprepared and used for subsequent in vitro transcription reactions. Heavy(HC) and light (LC) chain of the antibody were encoded as separateentities (Table 19). For the heavy chains of VRC01, the sequence of theIgG constant region of S057 and the sequence of an immunoglobulin kappalight chain constant region (GenBank: AGH70219.1) was used.

Vectors for in vitro transcription were constructed containing a T7promoter and a GC-enriched sequence coding for the heavy and/or lightchain of the antibody. An α-globin 3′-UTR, followed by an A64 poly(A)sequence and a C30 sequence, was inserted 3′ of the open reading frame(ORF). The C30 sequence was followed by a restriction site used forlinearization of the vector before in vitro transcription. Therespective CDS sequences as well as the sequences of the mRNA can beretrieved from Table 12. For capping of the mRNA, in vitro transcriptionwas conducted in the presence of cap analog. Cells were transfected withlipofectamin 2000 complexed mRNA.

TABLE 19 mRNA constructs mRNA construct encoded antibody RNA designR5319 (SEQ ID NO: VRC01 HC and LC encoded on 61372)/R5320 (SEQ separatemRNA molecules ID NO: 61383)

8.2 In Vitro Expression of the Functional Anti-HIV Antibody Evaluated byIgG ELISA

To demonstrate expression of in vitro-produced mRNA-encoded antibody,the supernatant obtained after transfection of BHK cells was subjectedto an IgG-specific ELISA where plates were coated with an anti-human IgGantibody. Antibody detection was obtained in a plate reader.

8.3 In Vitro Functionality of an Anti-HIV Antibody Evaluated in MAGI-R5Cells—Inhibitory Effect on HIV Infection

The inhibitory activity of the mRNA-encoded antibody of the invention onHIV infection is measured on the human MAGI R5 recombinant cell linecoexpressing the human CCR5 receptor and CD4 at their extracellularmembrane. The cells used in the assay contain the HIV-1 LTR promoterthat drives expression of β-gal upon infection (this driven by theinteraction of tat and the LTR).

Consequently, to demonstrate the functionality of anti-HIV antibody, thesupernatant obtained after transfection of BHK cells was subjected tothe virus entry test using MAGI-R5 cells which report the entry of HIVby chemo luminescence (Magi R5-Tropic Antiviral Assay performed atSouthern Research, Maryland, USA). Inhibition of virus entry correlateswith reduced RLU (relative light units). Upon virus entry, the receptor(CCR5) fused to beta-gal is expressed which is detected bychemo-luminescence, thus, the lower the RLU values the more inhibitionof virus entry is observed.

8.4 Results

As shown in FIG. 42 , mRNA encoding anti-HIV antibody expressedantibodies.

As shown in FIG. 43 , increasing concentrations of expressed anti-HIVantibody reduced virus entry in MAGI cells (CC=cell control containingcells only; VC=virus control containing also virus). Included as acontrol was commercially available recombinant VRC01 (FIG. 43C).mRNA-encoded VRC01 (FIG. 43B) inhibited the entry of HIV similar torecombinant VRC01 (FIG. 43C). Thus, the mRNA-encoded antibody of theinvention is able to protect a human recombinant cell line (MAGI R5cell) from the infection by a HIV virus.

Example 9: In Vitro Expression of mRNA-Encoded Rituximab

In these experiments the in vitro expression of mRNA-encoded Rituximaband binding to its native antigen was evaluated.

9.1. Preparation of mRNA

For the present example a DNA sequence encoding the Rituximab proteinwas prepared and used for subsequent in vitro transcription reactions.

A vector for in vitro transcription was constructed containing a T7promoter and a GC-enriched sequence coding for the heavy and light chainof the Rituximab antibody, separated by the internal ribosomal entrysite (IRES) from Encephalomyocarditis virus (EMCV). An α-globin 3′-UTR,followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′of the open reading frame (ORF). The C30 sequence was followed by arestriction site used for linearization of the vector before in vitrotranscription. This vector was transcribed in vitro in the presence of acap analog resulting in 5′-capped (m7G) mRNA (R3917; SEQ ID NO: 61337).

9.2 In Vitro Expression of the Rituximab Antibody Evaluated by ELISA

The expression of functional antibodies by mRNA-encoded Rituximab wasevaluated in vitro. To this end, HEK293T cells were transfected with 1μg or 4 μg of mRNA (R3917) using the Lipofectamine2000 reagent. 24 hoursafter the transfection, the supernatant was collected and used in ELISAto determine the expression of human antibodies.

9.3 In Vitro Expression of the Functional Rituximab Antibody Evaluatedby Flow Cytometry

To confirm the functionality of the in vitro-produced mRNA-encodedRituximab, the supernatant obtained after transfection of HEK293T cells(as described above) was used for staining of Raji cells (the cell lineexpressing human CD20) and the cells were analysed by flow cytometry(FACS). The concentration of Rituximab in the supernatant of thetransfected cells was calculated using a standard curve generated withthe commercially available Rituximab protein.

9.4 Results

In these experiments the in vitro expression of mRNA-encoded Rituximaband binding to its native antigen was evaluated.

As shown in FIG. 44 , the concentration of over 10 ng/ml of humanantibodies was detected in the supernatant of cells transfected with 4μg of R3917, the expression was dose-dependent and specific as noantibodies were detected in the supernatants of the sham-transfectedcells. These antibodies were functional as they recognized and boundCD20 antigen expressed on the surface of Raji cells (FIG. 45 ). Theestimated concentration of the antibodies using ELISA (here, a methodthat measures human antibodies) and flow cytometry (here, a method thatmeasures only functional Rituximab) was similar suggesting that allantibodies detected in the supernatant are fully functional.

Example 10: In Vitro Expression of mRNA-Encoded Anti-RSV F Antibody

In this experiment the in vitro expression of an mRNA-encoded antibodyagainst human respiratory syncytial virus F protein (anti-RSV Fantibody; Palivizumab) was investigated.

10.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directedagainst the human respiratory syncytial virus F protein (RSV F) (Synagisantibody) were prepared and used for subsequent in vitro transcriptionreactions. Heavy (HC) and light (LC) chain of the antibody were eitherlinked by the internal ribosomal entry site (IRES) fromEncephalomyocarditis virus (EMCV) or encoded as separate entities (Table20). Vectors for in vitro transcription were constructed containing a T7promoter and a GC-enriched sequence coding for the heavy and/or lightchain of the antibody. An α-globin 3′-UTR, followed by an A64 poly(A)sequence and a C30 sequence, was inserted 3′ of the open reading frame(ORF). The C30 sequence was followed by a restriction site used forlinearization of the vector before in vitro transcription. For cappingof the mRNA, in vitro transcription was conducted in the presence of capanalog.

TABLE 20 mRNA constructs encoded mRNA construct antibody RNA designR4179 (SEQ ID NO: anti-RSV F immuno- HC and LC encoded 61677)/R4181 (SEQglobulin on separate ID NO: 61699) mRNA molecules R4180 (SEQ ID NO:anti-RSV F immuno- HC and LC encoded 61688)/R4182 (SEQ globulin onseparate ID NO: 61710) mRNA molecules R3060 (SEQ ID NO: anti-RSV F HLA-2HC:EMCV-IRES:LC 61666)

10.2 In vitro expression of the anti-RSV-F antibodies evaluated byWestern blot analysis The expression of mRNA-encoded anti-RSV F antibodywas evaluated in vitro. To this end, BHK cells were transfected with 10μg of mRNA using the Lipofectamine2000 reagent. 24 hours after thetransfection, cells and supernatants were collected for Western blotanalysis to determine the expression of human antibodies.

10.3 Results

As shown in FIG. 46 , human antibodies were clearly detectable inlysates and supernatants of mRNA-transfected cells. However, theantibody level was strongly dependent on the format of antibodyrepresentation. The mRNA-transfected cells produced both, heavy andlight chain, while encoding heavy and light chain by separate mRNAmolecules instead of a bi-cistronic construct strongly improved theratio of heavy and light chain, thus giving rise to almost equivalentlevels of both chains. Expression was specific as no antibodies weredetected in the supernatants of mock-transfected cells.

The invention claimed is:
 1. A composition comprising: (I) an RNAcomprising (a) at least a first coding sequence, wherein the firstcoding sequence comprises a nucleic acid sequence at least 90% identicalto the RNA sequence of SEQ ID NO: 61574 and encoding a polypeptideaccording to SEQ ID NO: 61573; and (b) at least a second codingsequence, wherein the second coding sequence comprises a nucleic acidsequence at least 90% identical to the RNA sequence of SEQ ID NO: 61585and encoding a polypeptide according to SEQ ID NO: 61584, wherein thefirst coding sequence and the second coding sequence are present in thesame RNA molecule; or (II) (a) at least a first RNA molecule comprisingat least a first coding sequence, wherein the first coding sequencecomprises a nucleic acid sequence at least 90% identical to the RNAsequence of SEQ ID NO: 61574 and encoding a polypeptide according to SEQID NO: 61573; and (b) at least a second RNA molecule comprising at leasta second coding sequence, wherein the second coding sequence comprises anucleic acid sequence at least 90% identical to the RNA sequence of SEQID NO: 61585 and encoding a polypeptide according to SEQ ID NO: 61584.2. The composition according to claim 1, comprising: (I) an RNAcomprising (a) at least a first coding sequence, wherein the firstcoding sequence comprises a nucleic acid sequence at least 90% identicalto the RNA sequence of SEQ ID NO: 61574 and encoding a polypeptideaccording to SEQ ID NO: 61573; and (b) at least a second codingsequence, wherein the second coding sequence comprises a nucleic acidsequence at least 90% identical to the RNA sequence of SEQ ID NO: 61585and encoding a polypeptide according to SEQ ID NO: 61584, wherein thefirst coding sequence and the second coding sequence are present in thesame RNA molecule.
 3. The composition according to claim 1, comprising:(II) (a) at least a first RNA molecule comprising at least a firstcoding sequence, wherein the first coding sequence comprises a nucleicacid sequence at least 90% identical to the RNA sequence of SEQ ID NO:61574 and encoding a polypeptide according to SEQ ID NO: 61573; and (b)at least a second RNA molecule comprising at least a second codingsequence, wherein the second coding sequence comprises a nucleic acidsequence at least 90% identical to the RNA sequence of SEQ ID NO: 61585and encoding a polypeptide according to SEQ ID NO:
 61584. 4. Thecomposition according to claim 3, wherein the first and/or the secondRNA is monocistronic.
 5. The composition according to claim 3, whereinthe first and the second RNA is mRNA.
 6. The composition according toclaim 5, wherein the G/C content of the first and second codingsequences of the RNAs is increased compared to the G/C content of thecorresponding coding sequence of the corresponding wild-type RNA, and/orwherein the C content of the first and second coding sequences of theRNAs is increased compared to the C content of the corresponding codingsequence of the corresponding wild-type RNA, and/or wherein the codonsin the first and second coding sequences of the RNA are adapted to humancodon usage.
 7. The composition according to claim 5, wherein the firstand the second RNA comprise a 5′-CAP structure and at least one3′-untranslated region element (3′-UTR element).
 8. The compositionaccording to claim 5, wherein the first and/or the second RNA comprisesat least one histone stem-loop.
 9. A method of treating cancer, whereinthe method comprises administering to a subject in need thereof aneffective amount of the composition according to claim
 1. 10. The methodaccording to claim 9, further defined as a method of treating ametastatic cancer.
 11. The composition according to claim 3, comprising:(II) (a) at least a first RNA molecule comprising at least a firstcoding sequence, wherein the first coding sequence comprises a nucleicacid sequence at least 95% identical to the RNA sequence of SEQ ID NO:61574 and encoding a polypeptide according to SEQ ID NO: 61573; and (b)at least a second RNA molecule comprising at least a second codingsequence, wherein the second coding sequence comprises a nucleic acidsequence at least 95% identical to the RNA sequence of SEQ ID NO: 61585and encoding a polypeptide according to SEQ ID NO:
 61584. 12. Thecomposition according to claim 7, wherein the first and the second mRNAscomprise a modified nucleoside.
 13. The composition according to claim12, wherein the modified nucleoside is N1-methyl-pseudouridine.
 14. Thecomposition according to claim 2, wherein the RNA is a mRNA.
 15. Thecomposition according to claim 14, comprising: (I) an RNA comprising (a)at least a first coding sequence, wherein the first coding sequencecomprises a nucleic acid sequence at least 95% identical to the RNAsequence of SEQ ID NO: 61574 and encoding a polypeptide according to SEQID NO: 61573; and (b) at least a second coding sequence, wherein thesecond coding sequence comprises a nucleic acid sequence at least 95%identical to the RNA sequence of SEQ ID NO: 61585 and encoding apolypeptide according to SEQ ID NO:
 61584. 16. The composition accordingto claim 14, wherein said first and said second coding sequences areseparated by an internal ribosome entry site (IRES).
 17. The compositionaccording to claim 14, wherein the mRNA comprises a 5′-CAP structure andat least one 3′-untranslated region element (3′-UTR element).
 18. Thecomposition according to claim 17, wherein the mRNA comprises a modifiednucleoside.
 19. The composition according to claim 18, wherein themodified nucleoside is N1-methyl-pseudouridine.